INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)

INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Summary Report

SEIZED MATERIALS 2017/2 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Table of contents

Introduction 3 Page Comments from the International

Panel of Forensic Experts Page 3

NPS reported by ICE participants Page 5 Codes and Abbreviations Page 7 Sample 1 Analysis Page 8 Identified substances Page 8 Statement of findings Page 13 Identification methods Page 23 Summary Page 29 Z-Scores Page 30

Sample 2 Analysis Page 33 Identified substances Page 33 Statement of findings Page 38 Identification methods Page 48 Summary Page 54 Z-Scores Page 55

Sample 3 Analysis age P 58 Identified substances Page 58 Statement of findings Page 63 Identification methods Page 73 Summary Page 79 Z-Scores Page 80

Sample 4 Analysis Page 84 Identified substances Page 84 Statement of findings Page 86 Identification methods Page 92 Summary Page 98 Test Samples Information Samples Comments on samples Sample 1 SM-1 was prepared from a seizure containing 31.3 % (w/w) 3,4-methylenedioxypyrovalerone base. The test sample also contained lactose.

Sample 2 SM-2 was prepared from a seizure containing 5.6 % (w/w) amfetamine base. The test sample also contained caffeine and creatine.

Sample 3 SM-3 was prepared from a seizure containing 39.9 % (w/w) metamfetamine base. The test sample also contained lactose.

Sample 4 SM-4 was a blank test sample of damiana leaf and contained no substances from the ICE menu

Samples Substances Concentrations Comments on substances Sample 1 3,4-Methylenedioxypyrovalerone 31.3 % Lactose - Sample 2 Amfetamine 5.6 % Sample 3 Lactose - Metamfetamine 39.9 % Sample 4 [blank sample] -

This report contains the data received from laboratories participating in the current exercise. The results compiled in this report are not intended to be an overview of the quality of work and cannot be interpreted as such. These comments do not reflect the general state of the art within the profession.

Participant results are reported using a randomly assigned "WebCode". This code maintains participant's anonymity, provides linking of the various report sections, and will change with every report.

Introduction

An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact. The ICE programme is a UNODC mandated activity and is implemented through regular budget funds and through the UNODC Global Scientific and Forensic Programme – Support Project (GLOU54), which operationalizes the forensic aspects of the UNODC Thematic Programme on Research, Trend Analysis and Forensics"

Comments from the International Panel of Forensic Experts

Participation of Laboratories

In the 2017/2 round of the ICE programme, results were submitted within both the Seized Materials (SM) and Biological Specimens (BS) test groups by 241 laboratories in 74 countries. Within the SM test group, there were 200 participating laboratories from 68 countries and within the BS test group, results were submitted by 95 laboratories from 43 countries.

Qualitative Analysis

The analytical technique most commonly used for screening of test samples in the SM test group was the marquis reagent (39% of participants), while GC-MS (88% of participants) was the most commonly used technique for identification/confirmation of the components in the test samples followed by FTIR (39% of participants). The results for the qualitative identification of the controlled substances in the SM test group, the number of false positive/negative results and the analyses not performed are shown in the table 1.

Table 1. Performance of participants in the 2017/2 round of ICE.

SM-1 SM-2 SM-3 SM-4 Test sample (MDPV) (Amfetamine) (Metamfetamine) (Blank)

Correct identification by 97% 94% 100% 99% participants

Number of false 10 5 1 1 positives Number of false 3 11 0 1 negatives Number of Analyses not 3 3 0 0 performed

With regard to false negative results reported, there were a total of fifteen (three for SM-1, eleven for SM-2 and one for SM-4). In total, there were seventeen false positive results for controlled substances or new psychoactive substances. The overall number of false positive/negative results reported by ICE participants continues to be low and while this is encouraging, laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken in order to continuously improve performance. While there were only a total of six analyses not performed, ICE participants should notethat test samples can contain any of the substances in the ICE menu and screening and identificationcarried out should take this into account.

Quantitative Analysis

The number of participants who carried out quantitative analysis, 49 (25%) for SM-1, 98 (50%) for SM-2 and 103 (53%) for SM-3 continues to be encouraging. It is also encouraging that 113 (58%) of participants in the SM test group performed quantitation and of these, 88 (78%) quantified more than one substance and 49 (43%) quantified all three test samples. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution. With regard to the analytical techniques used by participants performing quantitation, 50% used GC-FID, 27% used HPLC and 21% used mass spectrometry. z-scores obtained by participants in quantification are shown in table 2 below.

Table 2. Quantitative performance of participants in the 2017/2 round of ICE.

Test sample z-score SM-1 SM-2 SM-3 SM-4 (MDPV) (Amfetamine) (Metamfetamine) (Blank) |z| < 2, satisfactory 80% 81% 83% - 2 ≤ |z| ≤ 3, questionable 2% 8% 7% - |z| > 3, unsatisfactory 18% 11% 10% -

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation. Participants with z-scores outside acceptable limits should review their quantification procedures.

In the 2017/1 round of ICE, twenty one laboratories obtained questionable z-scores with 2 ≤ |z| < 3. Eleven of these laboratories participated and performed quantification in the 2017/2 round with ten (91%) laboratories improving their performance and obtaining acceptable z-scores with |z| < 2 for at least one substance. Six (55%) of these laboratories also obtained unsatisfactory z-scores and one (9%) laboratory obtained a questionable z-score in 2017/2.

23 laboratories obtained unsatisfactory z-scores in ICE 2017/1 with |z| ≥ 3. Of these laboratories, 11 participated in ICE 2017/2 and performed quantification, with seven (64%) improving their performance in at least one substance. Seven (64%) of these laboratories also obtained an unsatisfactory z-score in the 2017/2 round and three (27%) obtained questionable z-scores.

The following laboratories obtained a single action signal or warning signal in the two successive rounds of 2017/1 and 2017/2 and shall take this as an anomaly, which requires further investigation: GLXRWX, VYHLIW, SSNSSS, RYT9EQ, UK1I4W, 6Y22ZW, TFIEH5, EP44XZ, 1M08A3, LDL46L, P9VJ99, 1M08A3, KR7NVL, VQI99W, ZM999M, BPKXUS, WWT4QM. Of the laboratories that obtained a single action or warning signal in ICE rounds 2016/2 and 2017/1, the following also obtained an action or warning signal in 2017/2 GLXRWX, KR7NVL, 6Y22ZW, TFIEH5, BPKXUS.

Laboratories that need to perform quantitation routinely are encouraged to participate regularly in external proficiency testing or collaborative exercises such as the ICE programme. This will enable laboratories to assess the quality of their quantitative methods through the z-score values obtained. In addition to the use of z-scores as a measure of performance in quantitation, participants are encouraged to compare their results with the assigned values provided in individual quantification reports, to assess the accuracy of their quantitative performance. Laboratories reporting false positive or false negative results should investigate the root causes and corrective actions taken promptly in order to continuously improve performance. Participation in the ICE programme also helps in monitoring the effect of corrective actions. UNODC would like to acknowledge the valuable contribution of the Chemical Metrology Laboratory of the Health Sciences Authority, Singapore, for the provision of specific software used for the quantitative statistical calculations in the ICE programme.

New Psychoactive Substances (NPS) reported by laboratories participating in the 2017/2 round of the ICE programme

During the 2017/2 round of ICE, participating laboratories in bothe the seized materials and biological specimens test groups provided information on NPS that had been identified in their laboratories. In total there were 185 reports of 113 substances. The most commonly reported substances were from the groups of synthetic cathinones (30%) followed by synthetic cannabinoids (29%) as shown in figure 1.

3% 7% Synthetic cannabinoids

9% 29% Synthetic cathinones

Others

Phenethylamines

Ketamine and phencyclidine 22% type substances Tryptamines

30%

Figure 1. NPS reported by ICE laboratories during the 201

7/2 round of ICE

In terms of the mode of action of the NPS reported by ICE participants, the predominant substances reported were stimulants (38%), while 29% were synthetic cannabinoid receptor agonists (SCRA’s) and 13% were synthetic opioids (which included seven fentanyl derivatives) as shown in figure 2.

7% 1%

12%

38% Stimulants

SCRA's

Opioids

13% Hallucinogens

Dissociatives

Sedatives/Hypnotics

29%

Figure 2. Mode of action of NPS reported by ICE participants in the 2017/2 round of ICE

NPS most commonly reported by laboratories participating in ICE 2017/2

The substance most often reported by ICE participants was the synthetic cathinone 4-chloro-alpha- pyrrolidinovalerophenone (4-Cl-alpha-PVP) followed by the synthetic cannabinoid receptor agonist 5F- MDMB-PINACA (methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate), and the synthetic opioid U-47700 (3,4-dichloro-N-((1S,2S)-2-(dimethylamino)cyclohexyl)-N-methylbenzamide). For further details on these substances and others reported to the UNODC Early Warning Advisory, ICEparticipants can log on to the UNODC ICE portal and select the icon for the Early Warning Advisory on New Psychoactive Substances as shown below.

Codes and Abbreviations

(+) “positive”: Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates that a positive reaction was obtained. (-) “negative”: Indicates that the analyte is not identified.

(ANP): Analysis not performed.

Tech Code Name 140 Colorimetric reactions 141 Marquis reagent (sulphuric acid, formaldehyde) 142 Cobalt thiocyanate 150 Thin Layer Chromatography 160 High/Ultra High Performance Liquid Chromatography 161 High Performance Liquid Chromatography with diode array detection 170 Gas Chromatography NPD 171 Gas Chromatography FID 172 Gas Chromatography ECD 180 Gas Chromatography/Mass Spectrometry 190 Fourier Transform Infrared Spectrometry 200 Spectrophotometry (visible, UV) 210 Others (specify) 211 NMR 220 Microcrystal test 230 Liquid chromatography/mass spectrometry 231 Liquid chromatography/tandem mass spectrometry

Sample 1 Analysis

Identified substances for Test Sample 1

Code Identified Substances 11IFBZ 3,4-Methylenedioxypyrovalerone (MDPV) 1M08A3 MDPV 1Q2SHP MDPV 1X1DOB 3,4-Methylenedioxypyrovalerone 22FT2U MDPV 2DZZAA 3,4-Methylenedioxypyrovalerone 2JEC6G MDPV 2NP2F2 MDPV 2PSK77 3,4-Methylenedioxypyrovalerone 2QBODQ MDPV 351XUF MDPV 3,4 metilendioxypirovalerona 35GJ4P MDPV 3JP0F0 3,4-Methylenedioxypyrovalerone 3SM8IQ MDPV 3TSMST 3,4-Methylenedioxypyrovalerone 3V331Z 3,4-methylendioxypyrovalerone HCl 3X0JH3 MDPV 42YCFB MDPV 466G6Q MDPV 4PADXD MPDV 513NM1 MDPV and Lincomycin 578QI0 3,4-Methylenedioxypyrovalerone 5G9GGA MDPV(NPS) 61CSWE MDPV 666ZAW MDPV 6AN2C2 MDPV 6O6Z2R MDPV (Methylenedioxypyrovalerone) 6RBI63 MPDV 6UM7YE MDPV 6UNASW Methyledioxypyrovalerone (MDPV) 6Y22ZW MDPV 8LC91S MDPV 8NOHFT MDPV 8OZNNH MDPV 8PPE6P MPDV 8PPPNP MDPV 966O36 3,4-methylenedioxypyrovalerone 99Y9E4 MDPV A4YOTY 3,4-Methylenedioxypyrovalerone (MDPV) A6PUUR MDVP, MDPPP

Code Identified Substances ABD4CQ Methylenedioxypyrovalerone AE3FR3 MDPV AFUTFF MDPV AO0IAA 3,4-methylenedioxypyrovalerone (MDPV) AZ4PMC MDPV B4PKM0 METHYLENEDIOXYPYROVALERONE (MDPV) B7VEKK Methylenedixypyrovalerone (MDPV) BBQPBH Methylenedioxypyrovalerone BI7ICF MDPV BOVSZV 3,4Methylenedioxypyrovalerone BPKXUS 3,4-Methylenedioxypyrovalerone BVCWMH MDPV CAZGVF 3,4 - Methylenedioxypyrovalerone CCTBNI 3,4-Methylenedioxypyrovalerone CCTTCS MDPV CFCSQ9 Methyledioxypyrovalerone CIVU6Z 3,4-Methylenedioxypyrovalerone CNOAFA 3,4-MDPV CQ8ETV 3,4-Methylenedioxypyrovalerone CQV27N MDPV CWI43Z Methylenedioxypyrovalerone (MDPV) DE2UO1 3,4-Methyllenedioxypyrovalerone(MDPV) DFLSLL MDPV DLBGLV 3,4-Methylenedioxypyrovalerone DW1X31 3,4-Methylenedioxypyrovalerone (MDPV) DXFKNP 3,4-methylenedioxypyrovalerone DXL6MM In Albania MDPV is not at the list of narcotic or psycotropic E6IWWC 3,4 Methyledioxypyrovalerone EEEYMJ 3,4-Methylenedioxypyrovalerone EGPGL2 3,4-Methylenedioxypyrovalerone EP44XZ Methylenedioxypyrovaleron (MDPV) ERZARV MDPV ETWSUN MDPV F7HCHW 3,4-Methylenedioxypyrovalerone FDFGFF 3,4-Methylenedioxypyrovalerone FFRV63 Methylenedixypyrovalerone(MDPV) FMM8M2 ninguno FMSMPJ Methylenedioxypyrovalerone HCl FNXHHJ Methylenedioxypyrovaleronr(MDPV) FV2JQI 3,4-Methylenedioxypyrovalerone G0W6IH 3,4-Methylenedioxypyrovalerone G6HDDD MDPV GLGABM MDPV GLXRWX Pyrovalerone

Code Identified Substances GMMUMM MDPV GY666S MDPV HJID9R we found a peak, but we can not identify it HMHSGW MDPV HRY21A MDPV HS1APR MDPV I34AKK MDPV IHPP3A MDPV IIRJKB Methylenedioxypyrovalerone(MDPV) IJK6H6 methyledioxypyrovalerone IKM3NM 3,4-Methylenedioxypyrovalerone J1DF1H MDPV JGFGUS MDPV JNJCC0 MDPV JVVOZV 3,4-Methylenedioxypyrovalerone JYLDDO methylenedioxypyrovalerone KCUSOU 3,4-Methylenedioxypyrovalerona(MDPV) KJUH9B 3,4-Methylenedioxypyrovalerone KKNZEW 3,4-MDPV (Methylenedioxypyrovalerone) KR7NVL 3,4-MDPV KVYCOZ MDPV KYRYY5 3,4-Methylenedioxypyrovalerone L69LUL MDPV HCl L7I3D7 MDPV LCKOL9 This sample contains 3,4-Methylenedioxypyrovalerone LDL46L Methylendioxy Pyrovalerona LFFAAE 3,4-Methylenedioxypyrovalerone LICCBC 3,4-methylenedioxypyrovalerone (MDPV) LIIPOC Methyenedioxypyrovalerone (MDPV) LMIMMX 3,4-Methylenedioxypyrovalerone LW5ETC 3,4- methylenedioxypyrovalerone LXWXMB 3,4-Methylenedioxypyrovalerone MGGBMM 3,4-Methylenedioxypyrovalerone MMRVDM 3,4-Methylenedioxypyrovalerone (MDPV) MZIUPW MDPV N888E4 MDPV,Canabidiol, morfina NUUUZ3 METHYLENEDIOXYPYROVALERONE (MDPV) NY3811 MDPV NYIIMJ 3,4-Methylenedioxypyrovalerone O4B4EZ 3,4-MDVP OCDXEB 3,4-Methylenedioxypyrovalerone OK9VLQ MDPV OOQANA Methyledioxypyrovalerone (MDPV) OUUFRA 3-4 MDPV

Code Identified Substances OWWFR9 MDPV hcl OZEL9J 3.4 MDPV P9VJ99 MDPV PFLXB1 Methyledioxypyrovalerone (MDPV) PNOHDD 3,4 MDPV and lactose PPHPXW MDPV PVVR87 MDPV Q14S11 3,4-Methylenedioxypyrovalerone Q20FHM 3,4-Methylendioxypyrovalerone Q4XQI4 MDPV QA3IQQ MPDV QBC668 MDPV QG9KLD 3,4-Methylenedioxypyrovalerone QJSIBS Methylenedioxypyrovalerone (MDPV) QVJ4GE 3,4-Methylenedioxypyrovalerone (MDPV) RH2SB2 methyldioxipirovalerone RJQT3B 3,4-methylenedioxypyrovalerone RNRTQ7 MPDV RRRFMH 3,4-MDPV RSWBPX MDPV RYRRRO MDPV RYT9EQ MDPV S4CLU9 3,4-Methylenedioxypyrovalerone SQ00PF MDPV and Lactose SSNSSS MDPV T5ZGNF MDPV TATTTH 3,4-MDPV HCl TCJ8LF Methylenedixypyrovalerone TCRCCF 3,4 MDPV TDYBWE Methylenedioxypyrovalerone TFIEH5 MDPV TIHNPE MDPV TJGBER Methylenedioxypyrovalerone(MDPV) TKUTMR MDPV TTT7VV METHYLENEDIOXYPYROVALERONE, LACTOSE TTT83P MDPV TW8WWT 3,4-MDPV TYHGZT 3,4-Methylenedioxypyrovalerone U1ZTV1 COCAINE AND LACTOSE U3LUJU MDPV UBB6JU MDPV UHQQQQ Methamphetamine and 3,4-methylenedioxyamphetamine UK1I4W MDPV VHOLZ9 MDPV

Code Identified Substances VNAAG2 3,4-methylenedioxypyrovalerone(MDV) VQI99W 3,4-Methylenedioxypyrovalerone VYHLIW 3,4-Methylenedioxypyrovalerone W2WK2G MDPV WWKYWV Methylenedioxypyrovalerone (MDPV) WWT4QM 3,4-Methylenedioxypyrovalerone XGWDIY MDPV (3,4-methylenedioxypyrovalerone) XJ7ZFQ 3,4-Methylenedioxypyrovalerone XPESEF MDPV XVF202 3,4-MDPV Hydrochloride XXZXFD 3,4-methylenedioxipirovalerone Y767IJ Canabidiol YJOK1X Methylenedioxypyrovalerone YQDKTM MDPV YRMRRY 3,4-Methylenedioxypyrovalerone YVZNNK Methylenedioxypyrovalerone (MDPV) YX6UOI 3.4 METHYLENDIOXYPYROVALERONE YZYVX7 MDPV Z3CTND 3,4-Methylenedioxypyrovalerone ZM999M 3,4-Methylenedioxypyrovalerone (MDPV) ZN3JO2 Methylenedixypyrovalerone (MDPV) ZZZLCZ 3,4-MDPV

Statement of findings for Test Sample 1

Code 3,4- Methylenedioxypyr Lactose ovalerone 11IFBZ + ANP Presence of MDPV was confirmed qualitatively 1M08A3 + ANP Powder containing MDPV 1Q2SHP + ANP MDPV is controlled by law (R.D. of 6/09/2017 annex IIb) 1X1DOB + ANP Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with 3,4- Methylenedioxypyrovalerone. 22FT2U + - sample 2017/2/SM-1 was found to contain Methylenedioxypyrovalerone(MDPV) 2DZZAA + - The sample corresponds to 3,4-Methylenedioxypyrovalerone 2JEC6G + + ./. 2NP2F2 + + White powder containing MDPV (not quantified) and lactose 2PSK77 + +

2QBODQ + +

351XUF + - no se encontraron otras sustancias alargadoras 35GJ4P + + The samples contains MDPV and lactose. MDPV is scheduled as illicit drug in France. 3JP0F0 + ANP Positive to 3,4-Methylenedioxypyrovalerone according colorimetric reactions and gas chromatography/mass spectrometry analysis. 3SM8IQ + ANP

3TSMST + - Test sample 2017/2/SM-1 was confirmed to contain 3,4-Methylenedioxypyrovalerone, a DEA Schedule I substance. 3V331Z + ANP The sample contains 30.4 % of 3,4-methylendioxypyrovalerone & also contains traces of MDPPP . 3X0JH3 + ANP Realizados los ensayos colorimaticos y confiram XXXX dio positiva para MDPV 42YCFB + +

466G6Q + - The sample contains MDPV (3,4-methylenedioxypyrovalerone). MDPV is a controlled substance in X. 4PADXD + -

Code 3,4- Methylenedioxypyr Lactose ovalerone 513NM1 + ANP Nature- Powder Color- White Odor- Odorless 578QI0 + + lactose 5G9GGA + + SM01 was found to contain MDPV and Lactose 61CSWE + - marquis reagent: negative reaction, cobalt thiocyanate: negative reaction, GC-MS: MDPV/compared with library spectrum of MDPV), FTIR:MDPV (compared with ir spectrum of MDPV), FTIR: lactose, spectrum of ethanol extract residue compared with IR spectrum of lactose) 666ZAW + ANP As minority compound: MDPP and MDPBP 6AN2C2 + - Powder contains MDPV-methylenedioxypyrovalerone 6O6Z2R + ANP Analysis of a representative sample of the powder revealed the presence of MDPV (Methylenedioxypyrovalerone). 6RBI63 + + White powder containing MPDV and lactos 6UM7YE + - The major compound we found in SM1 sample is MDPV after GC/MS injection. It should be noted that we had two small peaks that we could not identify. 6UNASW + + A fluffy weight powder which had a net weight of 224 milligrams which was found to contain Methyledioxyproverone (MDPV) and Lactose. 6Y22ZW + + MDPV was identified in SM-1 and percentage is 16.41. In addition to that lactose was identified in SM-1. 8LC91S + ANP Methylenedioxypyrovalerone is controlled under the Misuse of Drugs Act 1971 (as amended) as a Class B drug, by virtue of the fact that it is a compound structurally derived from 2-amino-1-phenyl-1 -propanone by substitution in the phenyl ring with an alkylenedioxy substituent; substitution at the 3- position with an alkyl substituent; and by inclusion of the nitrogen atom in a cyclic structure 8NOHFT + +

8OZNNH + ANP The sample contains MDPV (not quantified). 8PPE6P + ANP White powder containing MPDV 8PPPNP + in Austria new psychoactive Substance according to the law 966O36 + +

99Y9E4 + ANP The analyzed sample contain MDPV A4YOTY + + Presence of 3,4-Methylenedioxypyrovalerone hydrochloride and lactose was detected in the sample.

Code 3,4- Methylenedioxypyr Lactose ovalerone A6PUUR + - ONE MILIGRAM OF THE SAMPLE WAS WEIGHTED AND DILUITED IN TEN MILILITERS OF METHANOL, THEN IT WAS INJECTED DIRECTLY GY GC/MS ABD4CQ + + Results are normally reported in a table format, however I cannot get the table to display correctly on this online portal so I will write out the results fully for all four samples.

One brown glass bottle with a screw-top lid which contained lumpy white powder. This powder weighed 228 milligrams and was found to contain METHYLENEDIOXYPYROVALERONE (MDPV) and LACTOSE. Methylenedioxypyrovalerone is a Class B controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). AE3FR3 + + Lactose was also identified in trace amount. AFUTFF ANP ANP

AO0IAA + + Also it was found as a diluent: lactose. AZ4PMC + ANP

B4PKM0 + ANP 1971 CONVENTION ON PSYCHOTROPIC SUBSTANCES UN LIST II B7VEKK + ANP On 2017/2/SM-1 MDPV was detected. BBQPBH + ANP One glass bottle containing 0.22 grammes of a powder containing 0.07 grammes of methylenedioxypyrovalerone. BI7ICF + + MDPV in LACTOSE powder BOVSZV + + lactose BPKXUS + ANP - BVCWMH + ANP

CAZGVF + + On analysis, I found the sample 'SM-1' containing 3,4 - Methylenedioxypyrovalerone (MDPV) and Lactose CCTBNI + ANP Sample 2017/2/SM-1 found to contain 3,4-Methylenedioxypyrovalerone CCTTCS + + lactose was also present CFCSQ9 + ANP

CIVU6Z + + 3,4-Methylenedioxypyrovalerone hydrochloride 33.25%. The test sample contained LACTOSE CNOAFA + ANP Test sample represents white powder that contains new psychoactive substance 3,4-MDPV that isn't controlled in Bosnia and Herzegovina.

Code 3,4- Methylenedioxypyr Lactose ovalerone CQ8ETV + + SM-1 contains 3,4-methylenedioxypyrovalerone and lactose. CQV27N + ANP

CWI43Z + ANP The above article was examined and found to consist of a glass vial containing a quantity of white powder. The powder, which was not weighed, was analysed and found to contain Methylenedioxypyrovalerone (MDPV).

Methylenedioxypyrovalerone (MDPV) is a compound structurally derived from 2-amino-1-phenyl-1- propanone by substitution in the phenyl ring with an alkylenedioxy substituent; substitution at the 3- position with an alkyl substituent; and by inclusion of the nitrogen atom in a cyclic structure, and as such is a class B drug within the provisions of the Misuse of Drugs Act 1971. DE2UO1 + ANP -The sample obtains with the positive result with Marquis reagent - TLC The Rf sample obtain with the same Rf MDPV standard -Gc The Rt sample obtain with the same Rt MDPV standard DFLSLL + + white powder containing MDPV and lactose as diluent DLBGLV + -

DW1X31 + + 3,4-Methylenedioxypyrovalerone (MDPV) which is classified as synthetic cathinone was detected in sample 1. DXFKNP + - a substance identified is MDPV DXL6MM + ANP GC/MS analysis showed for the presence of MDPV. E6IWWC + ANP 3,4- MDPV is not scheduled by national law for drugs no: 02/l-128 EEEYMJ + ANP 3,4-Methylenedioxypyrovalerone EGPGL2 + + It has been detected the presence of 3,4-Methylenedioxypyrovalerone in the sample EHHHXU + - No controlled drugs detected in the sample. EP44XZ + + The sample contained 28.8% MDPV and addictionally lactose. ERZARV + - The test sample 2017/2/SM-1 was found to contain the controlled drug methylenedioxypylevalerone. ETWSUN + + This sample is MDPV F1K811 + ANP Based on the above analysis, the sample was found to contain methylenedioxypyrovalerone (MDPV) F7HCHW + -

FBZL7G ANP ANP

Code 3,4- Methylenedioxypyr Lactose ovalerone FDFGFF + + Was found 3,4-Methylenedioxypyrovalerone and lactose FFRV63 + + Lactose FMM8M2 + ANP 3,4-methylenedioxypyrovalerone FMSMPJ + + Methylenedioxypyrovalerone 30.41% as base and Lactose FNXHHJ + ANP Examination of the Powder SM-1 revealed the presence of controlled drugs methylenedioxypyrovalerone (MDPV) FV2JQI + + in the analysis was obtained (3,4-Methylenedioxypyrovalerone) controlled substance and (lactose) which is uncontrolled substance.

G0W6IH + + 3,4-Methylenedioxypyrovalerone and lactose G6HDDD + + The sample contains Lactose GLGABM + + Lactose GLXRWX + +

GMMUMM + - MDPV GY666S + - We found Methylenedioxypyrovalerone by GCMS analysis. HJID9R ANP -

HMHSGW + ANP MDPV was identified in the sample SM1. HRY21A + + LACTOSE HS1APR + +

I34AKK + ANP

IHPP3A + + Sample contained MDPV as hydrochloride and LACTOSE. Identification of MDPV by FTIR and GC/MS, quantification by GC/FID. Identification of LACTOSE by FTIR, HRMN and Colorimetric Reactions (Molish Test). IIRJKB + + Using the techniques CR, TLC, GC-MS, sample SM-1 was found to contain Methylenedioxypyrovalerone(MDPV). IJK6H6 + ANP Examination and analyses performed on the solid in SM-1 showed it to contain methyledioxypyrovalerone ( a psychoactive drug)

Code 3,4- Methylenedioxypyr Lactose ovalerone IKM3NM + + 3,4-Methylenedioxypyrovalerone INNAMX + +

J1DF1H + + Sample also contain lactose. The presence of drug confirmed by GC-MS.The hydrochloride form of MDPV was confirmed by the anion analysis and FTIR spectroscopy. JGFGUS + ANP Sample 2017/2/SM-1 a white agglomerated powder gave a positive result for MDPV, substance under national legislation on drugs JNJCC0 + + The sample contains Lactose JVVOZV + ANP SM-1 to contained 3,4-Methylenedioxypyrovalerone JYLDDO + + SM1 contains 33%(w/w) MDPV base with lactose. KCUSOU + ANP It was detected the presence of 3,4-Methylenedioxypyrovalerone (MDPV) in the sample analysed. KJUH9B + + The powder contains 31.2 ± 1.5 % (w/w) MDPV-base. The sample also contained lactose. KKNZEW + - The sample contains 34,4 % of 3,4-MDPV (3,4-Methylenedioxypyrovalerone) KR7NVL + +

KVYCOZ + -

KYRYY5 + + It also contains lactose L69LUL + + SM1contains MDPV and Lactose, with a concentration of 31.08% MDPV base. L7I3D7 + + SM1 contains MDPV with lactose; but we can't quantified because we dont have standard. LCKOL9 + ANP confirmed by gc ms LDL46L + -

LFFAAE + + STIMULANT LICCBC + ANP The sample was found to contain 3,4-methylenedioxypyrovalerone (MDPV). LIIPOC + - Item 2017/2/SM-1 was found to contain Methyenedioxypyrovalerone (MDPV), which is a class B controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). LMIMMX + - 3,4-Methylenedioxypyrovalerone LW5ETC + + 3,4- methylenedioxypyrovalerone +lactose

Code 3,4- Methylenedioxypyr Lactose ovalerone LXWXMB + + It was identificated 3,4-Methylenedioxypyrovalerone and lactose in SM-1 sample MGGBMM + ANP White powder sample analyzed contains 3,4-Methylenedioxypyrovalerone MMRVDM + + lactose MZIUPW + + MDPV + LACTOSE HYDROCHLORIDE FORM N888E4 + - MDPV Canabidiol Morfina

NUUUZ3 + + Test sample 2017/2/SM-1 contains Methylenedioxypyrovalerone (MDPV). It also contains Lactose. NY3811 + +

NYIIMJ + + the sample contains 3,4-Methylenedioxypyrovalerone O4B4EZ + ANP Satisfied with result obtained OCDXEB + + The coincidence in the mass fragmentogram between the analyzed sample and a spectral library indicate the 3,4-Methylenedioxypyrovalerone presence. OK9VLQ + + MDPV is on the list of drugs. OOQANA + ANP The sample 2017/2/SM-1 was found to contain Methyledioxypyrovalerone (MDPV). OUUFRA + + LACTOSE IS FOUND OWWFR9 + + MDPV hcl and Lactose. Purity base MDPV 28,14% (ww/w) OZEL9J + + lactose P9VJ99 + ANP That I examined and analysed the said sample and found it to contain: controlled substance(s) within the meaning of the Controlled Drug and Substances Act: Schedule I 17.1 Methylenedioxypyrovalerone (MDPV) PBP772 + ANP Sample 2017/2/SM-1 found to contain 3,4-methylenedioxypyrovalerone(MDPV) PFLXB1 + + Sample 2017/2/SM-1 consists of white powder. Methyledioxypyrovalerone (MDPV), a prohibited substance included in the National Law for Narcotics, is found to be present in this sample. PNOHDD + + We analized the sample by FTIR and GC-MS. We could identify lactose by colourimetric test. The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard.

Code 3,4- Methylenedioxypyr Lactose ovalerone PPHPXW + -

PVVR87 + ANP Class B controlled drug subject to the provisions of the Misuse of Drugs Act 1971 (Amendment) Order 2010 Q14S11 + - The result of the test of SM-1(31) received has confirmed that the mentioned sample contained 3,4- Methylenedioxypyrovalerone but we are not able to give a quantification result. Q20FHM + + lactose Q4XQI4 + + No quantification because this drug isn't usualy for us Lactose found QA3IQQ + ANP White powder containing MPDV (31.9%ww) which is controlled by national law QBC668 + ANP White powder containing MDPV QG9KLD + ANP SM-1 was found to contain 3,4-Methylenedioxypyrovalerone. QJSIBS + + This vial was found to contain 231 milligrams of a white powder. This powder was found to contain 30.2% Methylenedioxypyrovalerone (MDPV). MDPV is controlled as a Class B drug under the Misuse of Drugs Act 1971 (as amended). QVJ4GE + ANP The sample contains 3,4-methylenedioxypyrovalerone which is a cathinone class. RH2SB2 + +

RJQT3B + ANP White sample analysed by GC/MS was found to contain 3,4-MDPV. Sample Mass Spectrum exhibited the same fragmentation pattern as described by SWGDRUG monographs. RNRTQ7 + ANP

RRRFMH + -

RSWBPX + ANP MDPV was detected by GCMS but not quantified RYRRRO + ANP

RYT9EQ + + After chemical analysis performed the sample contents: 1/MDPV 2/ Lactose S4CLU9 + + Lactose SQ00PF + + The Test sample 2017/2/SM-1 was analyzed by Thin Layer Chromatography technique and was found to contain MDPV and Lactose.

Code 3,4- Methylenedioxypyr Lactose ovalerone SSNSSS + + contains an artifact of MDPV

T5ZGNF + ANP That I examined and analysed the said sample and found it to contain: controlled substance(s) within the meaning of the Controlled Drugs and Substances Act: Schedule I 17 .1. Methylenedioxypyrovalerone (MDPV) TATTTH + - - TCJ8LF + -

TCRCCF + - white powder colour statement TDYBWE + ANP The white powder was analysed and found to contain methylendioxypyrovalerone. TFIEH5 - ANP

TIHNPE + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drugs and Substances Act: Schedule I 17.1 Methylenedioxypyrovalerone (MDPV) TJGBER + + Table 1 Scedule 1 Narcotic substances (not use by medicine), apruved by GD 1088 aat 05.10.2004 RM (last update 27.02.2017) TKUTMR + ANP White powder containing MDPV (not quantified) TTT7VV + +

TTT83P + ANP From screening test by using (MR) and from confirmation test using (GC-MS) the sample was found to contain the controlled drug (MDPV). TW8WWT + -

TYHGZT + - 3,4-Methylenedioxypyrovalerone was detected in the sample by GC-MS and FTIR. U1ZTV1 - + Cocaine detected using two solvent systems and confirmed with HPLC with a percentage purity of 45.5% and lactose detected. U3LUJU + -

UBB6JU + ANP MDPV, appr. 30% UHQQQQ ANP ANP presence of Methamphetamine and 3,4-methylenedioxyamphetamine was confirmed by LC/MS/MS technique UK1I4W + + MDPV was found in the sample VHOLZ9 + + The sample contains MDPV, lactose VNAAG2 + ANP Sample SM-1 was found to contain 3,4-methylenedioxypyrovalerone (MDPV)

Code 3,4- Methylenedioxypyr Lactose ovalerone VQI99W + ANP

VYHLIW + + Lactose W2WK2G + - Both TLC and GCMS identify MDPV WWKYWV + ANP The sample was found to contain Methylenedioxypyrovalerone (MDPV), a Class B controlled substance under the Misuse of Drugs Act 1971. WWT4QM + + This substance was identified by colorimetric reaction, and using analytical techniques of Gas Chromatography / Mass Spectrometry and Fourier Transform Infrared Spectrometry. Quantification could not be performed due to the lack of methodologies. It sample contain Lactose too like adulterant XGWDIY + + lactose XJ7ZFQ + + The sample consist controlled drugs - 3,4-Methylenedioxypyrovalerone XPESEF + + MDPV + lactose XVF202 + - A composite was formed from 1 unit for testing. 3,4-MDPV hydrochloride confirmed in the composite. XXZXFD + ANP In the test sample 2017/2/SM-1 was detected 3,4-methylenedioxipirovalerone Y767IJ - -

YJOK1X + + Lactose is also present. YQDKTM + ANP

YRMRRY + ANP In sample 2017/2/SM-1 was found 3,4-Methylenedioxypyrovalerone YVZNNK + - This powder was found to contain methylenedioxypyrovalerone (MDPV), which is a Class B controlled substance under the provisions of the Misuse of Drugs Act 1971 (as amended). YX6UOI + ANP

YZ1O11 + ANP

YZYVX7 + ANP The sample SM-1 contains MDPV, 33.4% Z3CTND + - The sample contains MDPV (Methylenedioxypyrovalerone) which is listed as a controlled drug according to french order, appendix IV of February 22nd 1990. ZM999M + + MDPV was identified by GC-MS & quantified by GC.

Code 3,4- Methylenedioxypyr Lactose ovalerone ZN3JO2 + + The sample contains Methylenedixypyrovalerone (MDPV) and Lactosa ZZZLCZ + - The sample contains 3,4-MDPV. 3,4-MDPV is sheduled as illicit drug in France.

Identification methods for Test Sample 1

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Analytical Technique Codes Code 140 141 142 150 160 161 171 180 190 200 211 230 231 210 11IFBZ S SI I 1M08A3 S S S SI SI 1Q2SHP I S 1X1DOB S S S I I 22FT2U S I I 2DZZAA SI I S microscope 2JEC6G SI SI 2NP2F2 I SI 2PSK77 S I 2QBODQ S S SI SI I 351XUF S S S I I 35GJ4P I I I 3JP0F0 S S S I 3SM8IQ S S S I 3TSMST S S S I 3V331Z S SI I 3X0JH3 S S S I I S cafeina 42YCFB SI 466G6Q I I 4PADXD I SI 513NM1 S S SI I I 578QI0 I SI I 5G9GGA S I I SI 61CSWE S S S SI I 666ZAW S I I 6AN2C2 I I 6O6Z2R S S I I 6RBI63 SI 6UM7YE I S 6UNASW S S S I I S Simons 6Y22ZW S S I I I Fast Blue B salt test 8LC91S S S I 8NOHFT SI I 8OZNNH S S S I I

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 210 8PPE6P I SI 8PPPNP I I SI 966O36 S I I I 99Y9E4 SI ASAP-TOF A4YOTY S I I I A6PUUR SI I ABD4CQ S S I I S Duquenois-Levine reagent AE3FR3 S I SI I AFUTFF S S S I I AO0IAA I SI AZ4PMC I SI B4PKM0 I SI B7VEKK S I BBQPBH S S I SI BI7ICF SI I BOVSZV S S I I BPKXUS SI BVCWMH I SI I CAZGVF S I I CCTBNI I SI I Janovsky Reagent CCTTCS S I CFCSQ9 SI CIVU6Z S S S I I CNOAFA S S SI I Fast Blue B CQ8ETV I S I I CQV27N I SI I CWI43Z S I DE2UO1 S S S I DFLSLL SI I DLBGLV I SI DW1X31 SI I DXFKNP SI DXL6MM S S S SI E6IWWC S I I EEEYMJ SI I EGPGL2 I SI I EHHHXU S S S I I EP44XZ I I SI I ERZARV S S S SI I

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 210 ETWSUN S I I F1K811 S I F7HCHW S I SI SI FBZL7G I I I rapid test FDFGFF S I I FFRV63 S I I I FMM8M2 SI I FMSMPJ S S S I I I FNXHHJ SI I FV2JQI S S S I I G0W6IH S I G6HDDD I S I SI I GLGABM SI SI GLXRWX SI GMMUM SI SI SI S I I SI M GY666S SI I I HJID9R SI S S SI HMHSGW S S S I S TANRED HRY21A SI I HS1APR SI I34AKK S S S I I IHPP3A I SI I IIRJKB S S S I I I IJK6H6 S S S I I I IKM3NM S S I I INNAMX I SI J1DF1H S I I JGFGUS S S S I I JNJCC0 I SI SI SI I JVVOZV S S I JYLDDO I I KCUSOU S S S I KJUH9B S I I SI I KKNZEW SI I KR7NVL S S I I KVYCOZ I SI KYRYY5 S I I L69LUL S I L7I3D7 S I I I HPLC/RID

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 210 LCKOL9 SI I LDL46L I I I SI LFFAAE S I I LICCBC I SI LIIPOC S S SI I S Simon's test LMIMMX S I I LW5ETC SI I I LXWXMB I SI I MGGBM S I M MMRVDM S I SI SI MZIUPW I SI N888E4 S S S I I S Tanred NUUUZ3 S S I SI NY3811 S S I I NYIIMJ S I I O4B4EZ S I OCDXEB S S I I OK9VLQ SI I I I OOQANA S S S I OUUFRA S I I OWWFR9 S S S I I I XRD OZEL9J SI P9VJ99 S I I GC-FTIR PBP772 S I I Marquis, Frodhe, Simon, Janovsky PFLXB1 S S I I PNOHDD SI I PPHPXW I PVVR87 S S I Q14S11 S S S I I Q20FHM I SI I Q4XQI4 I SI I QA3IQQ I SI QBC668 S I I SI QG9KLD S I I QJSIBS S S I I SI 6.2.3 Duquenois-Levine (Negms) Colour Test QVJ4GE S I RH2SB2 S S S I I

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 210 RJQT3B S S S I S Presence of Trichomes by Microscopy. RNRTQ7 SI RRRFMH SI SI SI SI RSWBPX SI RYRRRO SI RYT9EQ S I S4CLU9 SI S SI I S Benedict SQ00PF S S SI S Fast Blue B Salt Test SSNSSS I I SI T5ZGNF S I I GC-FTIR TATTTH I S TCJ8LF I S I TCRCCF SI I TDYBWE I I TFIEH5 I SI TIHNPE S I I GC-FTIR TJGBER S S S I I I S dill-koppanyi TKUTMR I SI TTT7VV I SI I TTT83P S S I S Negm's test TW8WWT I SI TYHGZT S S S I I S Dragendorff U1ZTV1 SI I U3LUJU I S UBB6JU SI I UHQQQQ I S enzyme immunoassay UK1I4W S S SI VHOLZ9 S I I I VNAAG2 S I I VQI99W S I I I VYHLIW S S S SI I W2WK2G S I I WWKYW S I V WWT4QM SI S S I I XGWDIY I SI SI XJ7ZFQ I SI I XPESEF S I I XVF202 I SI

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 210 XXZXFD I Y767IJ S I YJOK1X I I S Raman Spectroscopy YQDKTM SI I YRMRRY SI YVZNNK S S I S Microscopy YX6UOI S S SI YZ1O11 I I I I YZYVX7 S S S I I S Z3CTND I I ZM999M S S S I I ZN3JO2 S I I ZZZLCZ SI I

RESPONSE SUMMARY FOR TEST SAMPLE 1

Participants: 200

The response summary of all 200 participating laboratories for the identification of SM-1, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample:

Substance Name Number of laboratories: 3,4-methylenedixypyrovalerone 193 Lactose 86

False positives for Test Sample-1:

Round Code: Substance reported: Tech Code: GLXRWX Pyrovalerone N/A U1ZTZ1 Cocaine 150/160 Y767IJ Canabidiol 150 UHQQQQ Methamphetamine + MDMA 231 ASPUUR 3,4-Methylenedioxy-α- 180/231 pyrrolidinopropiophenone- -α- N888E4 Canabidiol, Morphine 171/180 False negatives for Test Sample-1 (techniques(s) used or ANP):

Round Code: Tech Code: U1ZTZ1 150/160 Y767IJ 150 AFUTFF ANP HJID9R ANP TFIEH5 180 UHQQQQ ANP

Frequency of use of screening, identification and quantification techniques: Response Summary Participants 200 Technique 140 141 142 150 160 161 171 180 190 200 210 211 230 231 Screening (No.) 64 76 56 23 0 1 8 68 17 1 16 1 3 0 (%) 32.8 39.0 28.7 11.8 0.0 0.5 4.1 34.9 8.7 0.5 8.2 0.5 1.5 0.0 Identification (No.) 16 3 3 39 10 11 29 172 76 1 11 2 5 10 (%) 8.2 1.5 1.5 20.0 5.1 5.6 14.9 88.2 39.0 0.5 5.6 1.0 2.6 5.1 Quantification (No.) 0 0 0 0 9 31 56 20 0 0 0 4 1 3 (%) 0.0 0.0 0.0 0.0 8.0 27.4 49.6 17.7 0.0 0.0 0.0 3.5 0.9 2.7

Z-Scores for Test Sample 1

MDPV MDPV Deviation Code Concentration Deviation from Code Concentration z-score from robust z-score (mass%) robust average (mass%) average DXFKNP 3.4 -28.0 -14.3 FFRV63 31.7 0.3 0.1 6Y22ZW 16.4 -15.0 -7.6 XPESEF 31.7 0.3 0.2 B4PKM0 26.8 -4.6 -2.3 2QBODQ 31.8 0.4 0.2 OWWFR9 28.1 -3.3 -1.6 QA3IQQ 31.9 0.5 0.3 EP44XZ 28.8 -2.6 -1.3 GY666S 32.0 0.6 0.3 XVF202 29.0 -2.4 -1.2 TW8WWT 32.1 0.7 0.4 VQI99W 29.2 -2.2 -1.1 BVCWMH 32.6 1.2 0.6 SSNSSS 29.3 -2.1 -1.1 ETWSUN 32.7 1.3 0.7 GMMUMM 29.7 -1.7 -0.9 VYHLIW 32.7 1.3 0.7 A4YOTY 30.0 -1.4 -0.7 JYLDDO 33.0 1.6 0.8 UBB6JU 30.0 -1.4 -0.7 CIVU6Z 33.3 1.9 1.0 YZ1O11 30.0 -1.4 -0.7 YZYVX7 33.4 2.0 1.0 Q20FHM 30.1 -1.3 -0.6 IHPP3A 33.9 2.5 1.3 QJSIBS 30.2 -1.2 -0.6 KKNZEW 34.4 3.0 1.5 TCJ8LF 30.4 -1.0 -0.5 AZ4PMC 39.3 7.9 4.0 3V331Z 30.4 -1.0 -0.5 W2WK2G 40.1 8.7 4.5 FMSMPJ 30.4 -1.0 -0.5 GLXRWX 41.0 9.6 4.9 CCTTCS 30.6 -0.8 -0.4 RYT9EQ 44.1 12.7 6.5 EGPGL2 30.6 -0.8 -0.4 KR7NVL 47.3 15.9 8.1 578QI0 30.7 -0.7 -0.3 TFIEH5 57.0 25.6 13.1 XJ7ZFQ 30.8 -0.6 -0.3 UK1I4W 65.0 33.6 17.2 BBQPBH 30.9 -0.5 -0.2 L69LUL 31.1 -0.3 -0.1 KJUH9B 31.2 -0.2 -0.1 42YCFB 31.2 -0.2 -0.1 NY3811 31.4 0.0 0.0 BPKXUS 31.6 0.2 0.1 ZM999M 31.6 0.2 0.1

Round: 2017/2 Robust average = 31.4 % Substance: SM-1; MDPV UNODC value = 31.3 % 4.0

3.0

2.0 1.5 1.3 1.0 1.0

1.0 0.8 0.7 0.7 0.6 0.4 0.3 0.3 0.2 0.2 0.1 0.1 0.1 0.0 4.0 4.5 4.9 6.5 8.1 13.1 17.2 0.0 7.6 - 0.1 0.1 14.3 - - 0.1 - - 0.2 0.3 - 0.3 - 0.4 0.4 - .5 .5 6 - - 0.5 0 0 - - - 0. 0.6 - 0.7 0.7 0.7 -1.0 - - - - 0.9 - 1.1 1.1 - - 1.2 - 1.3 - 1.6

-2.0 - 2.3 -

-3.0

-4.0 0 W SS TY XZ 02 R9 QJSIBS TCJ8LF TFIEH5 L69LUL XPESEF SSNS 578QI0 XJ7ZFQ CIVU6Z IHPP3A EP44 CCTTCS 42YCFB FFRV63 YZYVX7 XVF2 3V331Z GY666S JYLDDO YZ1O11 KJUH9B NY3811 RYT9EQ A4YO UBB6JU EGPGL2 BPKXUS KR7NVL VYHLIW DXFKNP UK1I4W 6Y22ZW QA3IQQ VQI99 BBQPBH B4PKM FMSMPJ AZ4PMC KKNZEW GLXRWX ETWSUN Q20FHM 2QBODQ ZM999M OWWF W2WK2G BVCWMH TW8WWT GMMUMM

z-scores can be interpreted by participants in line with ISO 13528:2005, secion 7.4.2 and ISO/IEC guide43-1:1997(E) as follows: IzI < 2 = satisfactory 2 ≤ IzI ≤ 3 = questionable IzI > 3 = unsatisfactory Accordig to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z- score is considered to give a warning signal. A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occured that requires inverstigation.

Round: 2017/2 Substance: SM-1; MDPV

Dispersion of z-scores using different analytical techniques for the quantification of MDPV in 2017/2 SM-1 10.0

8.0

6.0

4.0

2.0

0.0 score - z

-2.0

-4.0

-6.0 HPLC GC-FID GC-MS -8.0 NMR + LC/MS HPLC GC-FID GC-MS -10.0

Sample 2 Analysis

Identified substances for Test Sample 2

Code Identified Substances 11IFBZ Amfetamine, Caffeine 1M08A3 Anfetamine 1Q2SHP amfetamine 1X1DOB Amfetamine 22FT2U Amphetamine 2DZZAA Anphetamine AND caffeine 2JEC6G Amfetamine 2NP2F2 amfetamine 2PSK77 Amfetamine 2QBODQ Amfetamine 351XUF ANFETAMINA 35GJ4P amfetamine 3JP0F0 Amfetamine and Caffeine 3SM8IQ Amphetamine 3TSMST Amphetamine 3V331Z Amphetamine 3X0JH3 cafaina 42YCFB Amphetamine 466G6Q Amphetamine 513NM1 Amphetamine and Caffeine 578QI0 amfetamine 5G9GGA Amphetamine 61CSWE Amfetamine 666ZAW amphetamine 6AN2C2 Amphetamine 6O6Z2R Amphetamine 6RBI63 amphetamine 6UNASW Amfetamine 6Y22ZW Amphetamine 8LC91S Amphetamine (and caffeine) 8NOHFT amphetamine 8OZNNH Amphetamine 8PPE6P amfetamine 8PPPNP Ampehatmine 966O36 amfetamine 99Y9E4 Amfetamine A4YOTY Amphetamine A6PUUR AMPHETAMINE, CAFEINE ABD4CQ Amphetamine AE3FR3 amphetamine

Code Identified Substances AFUTFF AMPHETAMINE, CAFFEINE AO0IAA Amphetamine AZ4PMC Amphetamine B4PKM0 AMPHETAMINE AND CAFFEINE B7VEKK Amfetamine BBQPBH Amphetamine BI7ICF AMFETAMINE BOVSZV Amfetamine BPKXUS Amfetamine BVCWMH amphetamine CAZGVF Amphetamine CCTBNI Amfetamine CCTTCS amphetamine, caffeine CFCSQ9 Amfetamine CIVU6Z Amphetamine CNOAFA AMPHETAMINE CQ8ETV Amfetamine CQV27N Amphetamine CWI43Z Amphetamine DE2UO1 Amfetamine DFLSLL amphetamine DLBGLV Amfetamine DW1X31 Amphetamine DXFKNP amphetamine DXL6MM Amphetamine E6IWWC Amphetamine EEEYMJ amphetamine EGPGL2 Amfetamine EHHHXU Amphetamine EP44XZ Amphetamine ERZARV Amfetamine ETWSUN Amfetamine F1K811 Amphetamine F7HCHW Amfetamine 4.6% + Caffeine FBZL7G amphetamine FDFGFF Amfetamine FFRV63 Amfetamine FMM8M2 ninguno FMSMPJ Amphetamine Sulphate FNXHHJ Amphetamine and Caffeine FV2JQI dextroamphetamine G0W6IH amfetamine G6HDDD Amphetamine GLGABM Amfetamine

Code Identified Substances GLXRWX AMFETAMINE GMMUMM amfetamine GY666S Amphetamine and Caffeine HJID9R Amfetamine HMHSGW Amfetamine HRY21A AMPHETAMINE HS1APR AMFETAMINE I34AKK amfetamine ,caffeine IHPP3A Amfetamine IIRJKB Caffeine IJK6H6 amfetamine and caffeine IKM3NM ANFETAMINE J1DF1H Amphetamine JGFGUS AMPHETAMINE JNJCC0 Amphetamine JVVOZV Amphetamine JYLDDO amfetamine KCUSOU Amphetamine KJUH9B Amfetamine KKNZEW Amphetamine KR7NVL AMPHETAMINE KVYCOZ $0)(7$0ø1 KYRYY5 Amfetamine L69LUL Amfetamine Sulphate L7I3D7 caffeine LCKOL9 This samplke contains Amfetamine LDL46L Amfetamine LFFAAE amfetamine LICCBC Amphetamine LIIPOC Amphetamine and caffeine LMIMMX Amfetamine LW5ETC Amphetamine LXWXMB AMPHETAMINE MGGBMM Amfetamine MMRVDM amphetamine MZIUPW AMFETAMINE N888E4 Anfetamina, cafeina NUUUZ3 Amphetamine NY3811 amfetamine NYIIMJ Amfetamine O4B4EZ Amphetamine OCDXEB Amphetamine OK9VLQ Amphetamine OOQANA Amfetamine

Code Identified Substances OUUFRA AMPHETAMINE OWWFR9 Amphetamine sulphate OZEL9J amfetamine sulfate P9VJ99 Amphetamine and caffeine PBP772 caffeine and amphetamine PNOHDD Amfetamine and caffeine PPHPXW Amphetamine PVVR87 Amphetamine Q14S11 Amfetamine Q20FHM Amfetamine Q4XQI4 Amphétamine QA3IQQ amfetamine QBC668 Amphetamine QG9KLD Amfetamine QJSIBS Amphetamine QVJ4GE Amphetamine RH2SB2 Amphetamine and Cocaine RJQT3B Amphetamine RNRTQ7 amfetamine RRRFMH Anfetamina RSWBPX amfetamine RYT9EQ Amfetamine S4CLU9 Amfetamine, Caffeine SQ00PF Amfetamine and Caffeine SSNSSS Amphetamine T5ZGNF Amphetamine and caffeine TATTTH amphetamine sulfate TCJ8LF Amfetamine, Caffeine TCRCCF Amphetamine TDYBWE Amphetamine TFIEH5 Amfetamine TIHNPE Amphetamine and caffeine TJGBER Amphetamine TKUTMR amfetamine TTT7VV AMPHETAMINE TTT83P Amphetamine TW8WWT Amfetamine TYHGZT Amphetamine U1ZTV1 1-(3 chlorophenyl piperazine and Lactose U3LUJU amfetamine UBB6JU Amfetamine UHQQQQ dextroamphetamine and temazepam UK1I4W Amphetamine VHOLZ9 amphetamine

Code Identified Substances VNAAG2 Amphetamine VQI99W AMFETAMINE VYHLIW Amfetamine W2WK2G Amphetamine and Caffeine WWKYWV Amphetamine WWT4QM Amphetamine XGWDIY amphetamine XJ7ZFQ Amfetamine XPESEF Amphetamine XVF202 Amphetamine XXZXFD Amphetamina Y767IJ Heroine YJOK1X Amfetamine YQDKTM CAFEINE YRMRRY none YVZNNK Amphetamine, caffeine YX6UOI AMPHETAMINE YZYVX7 Amfetamine Z3CTND Amfetamine ZM999M Amfetamine ZN3JO2 Amfetamine ZZZLCZ Amphétamine

Statement of findings for Test Sample 2

Code Amfetamine 11IFBZ + Presence of Amfetamine and Caffeine was confirmed qualitatively 1M08A3 + Powder containg Anfetamine (residual) and Caffeine 1Q2SHP + Amfetamine is controlled by law (R.D. of 6/09/2017 annex IIb) 1X1DOB + Results of screening tests were positive for amfetamines. Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with amfetamine. 22FT2U + sample 2017/2/SM-2 was found to contain Amphetamine 2DZZAA + The sample corresponds anphetamine and cafeine 2JEC6G + ./. 2NP2F2 + White powder containing amfetamine (not quantified), caffeine and maltose (not listed) 2PSK77 +

2QBODQ + caffeine, creatine 351XUF + se identifico tambien la presencia de cafeina en esta muestra 35GJ4P + The samples contains amfetamine, caffeine and creatine. Amfetamine is scheduled as illicit drug in France. 3JP0F0 + Positive to Amfetamine and Caffeine according colorimetric reactions and gas chromatography/mass spectrometry analysis. 3SM8IQ + Also contains caffeine 3TSMST + Test sample 2017/2/SM-2 was confirmed to contain amphetamine, a DEA Schedule II substance. Our findings also show that Test sample 2017/2/SM-2 also contains caffeine. 3V331Z + The sample contains 5.4 % of amphetamine & also contains caffeine . 3X0JH3 ANP Realizados los ensayos colorimaticos y confiram XXXX dio positiva para Cafaina 42YCFB +

466G6Q + The sample contains amphetamine. The content of amphetamine is determined to 7% (as amphetaminesulphate). Amphetamine is a controlled substance in X. 4PADXD - no drugs, caffeine

Code Amfetamine 513NM1 + Nature- Powder Color- White Odor- Odorless 578QI0 + creatinine, caffeine 5G9GGA + SM02 was found to contain Amphetamine and Caffeine 61CSWE + marquis reagent: positive reaction, cobalt thiocyanate: negative result, GC-MS: Amfetamine/compared with library spectrum of Amfetamine and retention time of reference substance) and caffeine (compared with MS spectrum of caffeine)FTIR creatine (spectrum of ethanol extract residue compared with IR spectrum of creatine), precipitation reaction of BaCl2:Sulphate GC-FID: 7.02% amfetamine sulfate/ compared with reference standard- 666ZAW + caffeine as cutting substance 6AN2C2 + Powder contains amphetamine. 6O6Z2R + Analysis of a representative sample of the powder revealed the presence of amphetamine with a purity of approximately 6% (calculated as base). 6RBI63 + White powder containing amphetamine, caffeine and another unidentified compound whose molecular mass seems to be 185 or 113 6UM7YE - We found in SM2 sample after inhecting to the GC/MS is cafein. It is the only molecule we found in this sample. 6UNASW + A Pale yellow powder which had a net weight of 228 milligrams which was found to contain Amphetamine, Caffeine and Creatine monohydrate, with an amphetamine purity of 7% (purity reported as the sulphate form of amphetamine). 6Y22ZW + Amphetamine was identified in SM-2 and the percentage is 1.82. In addition to that caffeine was identified in SM-2. 8LC91S + Amphetamine at less than 5% purity 8NOHFT +

8OZNNH + The sample contains amphetamine (6%) and caffeine. 8PPE6P + Yellow powder containing amfetamine 8PPPNP + in Austria illegal drug according to the law 966O36 +

99Y9E4 + the analyzed sample contain Amphetamine A4YOTY + Presence of amphetamine sulphate, caffeine and creatine was detected in the sample.

Code Amfetamine A6PUUR + ONE MILIGRAM OF THE SAMPLE WAS WEIGHTED AND DILUTED IN 10 ML OF METHANOL. THEN IT WAS INJECTED DIRECTLY BY CG-MS ABD4CQ + One brown glass bottle with a screw-top lid which contained lumpy off-white powder. This powder weighed 229 milligrams and was found to contain an average of 5% AMPHETAMINE, along with CAFFEINE and CREATINE MONOHYDRATE. Amphetamine is a Class B controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Caffeine and creatine monohydrate are not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). AE3FR3 + Creatine and coffeine were also identified. AFUTFF + The Sample contains Amphetamine. The seized material also contains caffeine. AO0IAA + Also it was found as a diluent: caffeine. AZ4PMC + Cofeine B4PKM0 + AMPHETAMINE IS LISTED IN 1971 CONVENTION ON PSYCHOTROPIC SUBSTANCES UN LIST II B7VEKK + On 2017/2/SM-2 amfetamine was detected. BBQPBH + One glass bottle containing 0.21 grammes of a powder containing 0.01 grammes of amphetamine. BI7ICF + AMFETAMINE, CAFFEINE, CREATINE powder BOVSZV + Cafeine BPKXUS + - BVCWMH + also present: caffeine CAZGVF + On analysis, I found the sample 'SM-1' containing Amphetamine, caffeine and creatine CCTBNI + Sample 2017/2/SM-2 found to contain Amfetamine CCTTCS + lactose was also present CFCSQ9 +

CIVU6Z + Amphetamine Sulfate 5.35%. The test sample contained CAFFEINE CNOAFA + Test sample represents white powder that contains amphetamine (controlled drug) and substance caffeine. CQ8ETV + SM-2 Contains amfetamine, caffeine, creatine and lactose. CQV27N + caffeine

Code Amfetamine CWI43Z + The above article was examined and found to consist of a glass vial containing a quantity of off- white powder. The powder, which was not weighed, was analysed and found to contain Amphetamine. A sample of the powder was further analysed and found to contain ??% (weight for weight) Amphetamine.

Amphetamine is a class B controlled drug within the provisions of the Misuse of Drugs Act 1971.

DE2UO1 + -The sample obtains with the positive result with Marquis reagent - TLC The Rf sample obtain with the same Rf Amfetamine standard -Gc The Rt sample obtain with the same Rt Amfetamine standard DFLSLL + white powder containing amphetamine and caffeine and creatine as diluents DLBGLV + Caffeine DW1X31 + Amphetamine in the ratio of %5 was detected in sample 2. DXFKNP + a substance identified is amphetamine DXL6MM + GC/MS analysis showed for the presence of caffeine and Amphetamine. E6IWWC + - EEEYMJ + amphetamine and caffeine EGPGL2 + It has been detected the presence of amfetamin in the sample and caffeine EHHHXU + On analysis, I found that the white powdery substances contain of 11.4%w/w of amphetamine, creatine and caffeine. EP44XZ + The sample contained 5.7% amphetamine and additionally caffeine and creatine. ERZARV + The test sample 2017/2/SM-2 was found to contain the controlled drug amfetamine. ETWSUN + This sample is amfetamine. F1K811 + Based on the above analysis, the sample was found to contain amphetamine and caffeine F7HCHW +

FBZL7G +

FDFGFF + Was found Amfetamine and Coffein. FFRV63 + Caffeine and creatine FMM8M2 + Anfetamina

Code Amfetamine FMSMPJ + Amphetamine 5.42% as base and Caffeine 28.03% FNXHHJ ANP Examination of the Powder SM-2 revealed the presence of controlled drugs Amphetamine FV2JQI + in the analysis was obtained (dextroamphetamine) which is a enantiomer right molecule amphetamine, and (caffeine) which is uncontrolled substance. G0W6IH + amfetamine and caffeine G6HDDD +

GLGABM + caffeine GLXRWX +

GMMUMM + amfetamine,caffeine GY666S + We found Amphetamine and Caffeine by GCMS analysis. HJID9R + we find caffeine too HMHSGW + The sample SM-2 contains Amphetamine and Caffeine HRY21A +

HS1APR +

I34AKK +

IHPP3A + Sample contained Anfetamine as hydrochloride, Caffeine and Creatine. Identification of Anfetamine by HRMN and GC/MS, quantification by GC/FID. Identification of Caffeine by FTIR, GC/MS, and Creatine by FTIR and HRMN. Test). IIRJKB - Using the techniques CR, TLC, GC-MS, sample SM-2 was found to contain Caffeine. IJK6H6 + Examination and analyses performed on the solid in SM-2 showed it to contain amfetamine ( a central stimulant) and caffeine (a xanthine stimulant) IKM3NM + ANFETAMINE INNAMX +

J1DF1H + Sample also contain caffeine and creatine. The presence of drug confirmed by GC-MS and HPLC- DAD. JGFGUS + Sample 2017/2/SM-2 a white powder gave a positive result for Amphetamine, substance under national legislation on drugs. Caffeine was also detected.

Code Amfetamine JNJCC0 +

JVVOZV + SM-2 to contained Amphetamine and Caffeine JYLDDO + SM2 contains 9% (w/w) amfetamine base with caffeine and creatine. KCUSOU + It was detected the presence of Amfetamine in the sample analysed. KJUH9B + The powder contains 5.38 ± 0.41 % (w/w) amfetamine-base. The sample also contained caffeine and creatine. KKNZEW + The sample contains 5,9 % of amphetamine (free base) KR7NVL +

KVYCOZ + &$)(ø1 KYRYY5 + It also contains caffeine L69LUL + SM2 contains Amfetamine, Caffeine and Creatine, with a concentration of 4.72% Amfetamine base. L7I3D7 - SM2 contains caffeine . LCKOL9 + confirmed by gc ms LDL46L + Cafeine LFFAAE + STIMULANT LICCBC + The sample was found to contain amphetamine. LIIPOC + Item 2017/2/SM-2 was found to contain amphetamine, which is a class B controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended) at a purity of 5.7% along with the adulterants Caffeine and Creatine (indicated). LMIMMX + %5,8 Amfetamine LW5ETC + Amphetamine+caffeine LXWXMB + It was identificated amphetamine, caffeine and creatine in SM-2 sample. MGGBMM + White powder sample analyzed contains Amfetamine MMRVDM + caffeine and creatine-monohydrate MZIUPW + AMFETAMIN + CAFFEINE SULFATE FORM

Code Amfetamine N888E4 + Cafeína Anfetamina NUUUZ3 + Test sample 2017/2/SM-2 contains Amphetamine. It also contains Caffeine. NY3811 +

NYIIMJ + the sample contains Amfetamine O4B4EZ + Caffeine also detected in the sample OCDXEB + The quemical tests and the concidence in the time of retention and mass fragmentogram with the material of reference used in the same conditions that the analyzed sample, they indicate in this one the Amphetamine presence. OK9VLQ + Amphetamine is on the list of drugs. OOQANA + The sample 2017/2/SM-2 was found to contain Amfetamine. The sample was also found to contain caffeine. OUUFRA + CAFFEINE IS FOUND OWWFR9 + Amphetamine sulphate, Caffeine and Creatine. Purity base amphetamine 5,25% (w/w) OZEL9J + cafeine, creatine P9VJ99 + That I examined and analysed the said sample and found it to contain: controlled substance(s) within the meaning of the Controlled Drug and Substances Act:Schedule I 19. (1) Amphetamine (alpha-methylbenzeneethanamine)

Substance(s) that are not controlled under the Controlled Drugs and Substances Act or included on the Prescription Drug List under the Food and Drug Act: Caffeine PBP772 + Sample 2017/2/SM-2 found to contain caffeine and amphetamine PFLXB1 - Sample 2017/2/SM-2 consists of white powder.No prohibited substances are detected in this sample. PNOHDD + The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard. We could identify creatinine. PPHPXW +

PVVR87 + Class B controlled drug subject to the provisions of the Misuse of Drugs Act 1971 Q14S11 + The result of the test of SM-2 (34) received has confirmed that the mentioned sample contained Amfetamine (and caffeine as not controlled drug) but we are not able to give a quantification result of Amfetamine. Q20FHM + Caffeine

Code Amfetamine Q4XQI4 + No quantification because lack of standard Caffein found QA3IQQ + White powder containing amfetamine (1.9%ww) which is controlled by national law QBC668 + White powder containing amphetamine and caffeine QG9KLD + SM-2 was found to contain amfetamine QJSIBS + This vial was found to contain 228 milligrams of an off-white powder. This powder was found to contain 5.2% Amphetamine. Amphetamine is controlled as a Class B drug under the Misuse of Drugs Act 1971 (as amended). QVJ4GE + The sample contains amphetamine which is Amfetamine Type Stimulants. RH2SB2 + Cocaína se encontraba en trazas RJQT3B + White sample analysed by GC/MS was found to contain Amphetamine. Sample Mass Spectrum was similar to reference material. RNRTQ7 +

RRRFMH + Adulterantes:cafeina RSWBPX + amfetamine was detected by GCMS and quantified by GCFID RYRRRO - CAFFEINE RYT9EQ + After chemical analysis performed the sample contents: 1/ amfetamine 2/ caffiene S4CLU9 +

SQ00PF + The Test sample 2017/2/SM-2 was analyzed by Thin Layer Chromatography technique and was found to contain Amfetamine and Caffeine. SSNSSS + contains caffeine T5ZGNF + That I examined and analysed the said sample and found it to contain: controlled substance(s) within the meaning of the Controlled Drugs and Substances Act: Schedule I 19. (1) Amphetamine a-methylbenzeneethanamine)

Code Amfetamine TCJ8LF +

TCRCCF + white powder colour statement TDYBWE + The white powder was analysed and found to contain amphetamine. TFIEH5 +

TIHNPE + The sample was found to contain a controlled substance within the meaning of the Controlled Drugs and Substances Act: Schedule I 19. (1) Amphetamine Įmethylbenzeneethanamine).

That I examined and analysed the said sample and found it to contain: substance(s) that are not scheduled under the Controlled Drugs and Substances Act or included on the Prescription Drug List under the Food and Drugs Act: Caffeine TJGBER + Table 2 Scedule 2 Narcotic substances (use by medicine), apruved by GD 1088 aat 05.10.2004 RM (last update 27.02.2017 TKUTMR + powder yellowish containing 5.1%ww of amfetamine TTT7VV + CAFFEINE WAS ALSO DETECTED TTT83P + From screening test by using (MR) and (Ion scan) and from confirmation test using (GC-MS) the sample was found to contain the controlled drug (Amphetamine). TW8WWT + Amphetamine in mixture with creatine and caffeine TYHGZT + Amphetamine drug was found as minor component of the sample received. Caffeine was the major component. U1ZTV1 - The drugs were detected using two solvent systems. U3LUJU + amfetamine+caffeine UBB6JU + Amfetamine, appr. 5%. Also caffeine is present UHQQQQ ANP Presence of dextroamphetamine and temazepam was confirmed by LC/MS/MS technique UK1I4W + Amphetamine and caffeine was found in the sample VHOLZ9 + The sample contains amphetamine, caffeine, creatin-monohydrate VNAAG2 + Sample SM-2 was found to contain amphetamine. Also contain caffeine. VQI99W + THE SAMPLE ALSO CONTAINS CAFFEINE VYHLIW + Caffeine,createnine W2WK2G + Both TLC and GCMS identify Amphetamine and Caffeine

Code Amfetamine WWKYWV + The sample was found to contain Amphetamine, a Class B controlled substance under the Misuse of Drugs Act 1971. This sample was also found to contain Caffeine, which is not controlled under the Misuse of Drugs Act 1971. WWT4QM + This substance was identified by Marquis Reagent, and using analytical techniques of Gas Chromatography / Mass Spectrometry and Fourier Transform Infrared Spectrometry. And we obtained a quantification of 9,97% using HPLC-DAD techniques. It sample contain Caffeine too like adulterant XGWDIY + caffeine, creatin XJ7ZFQ + The sample consist controlled drugs - Amfetamine XPESEF + Amphetamine + creatine monohydrate + caffeine XVF202 + A composite was formed form 1 unit for testing. Amphetamine, caffeine, and creatine confirmed in the composite. XXZXFD + In the test sample 2017/2/SM-2 was detected amphetamine and caffeine Y767IJ -

YJOK1X + Caffeine and Creatine are also present. YQDKTM -

YRMRRY - In sample 2017/2/SM-2 was found caffeine YVZNNK + This powder was found to contain amphetamine at a concentration of 5%, together with the adulterant caffeine. Amphetamine is a Class B controlled substance under the provisions of the Misuse of Drugs Act 1971 (as amended). Caffeine is not controlled under the aforementioned Act. YX6UOI +

YZ1O11 +

YZYVX7 + The sample SM-2 contains amfetamine, 5.1% The sample also contains coffeine Z3CTND + The sample contains amfetamine which is listed as a controlled drug according to french order, appendix III of February 22nd 1990. ZM999M + Amfetamine was identified by GC-MS & quantified by GC. ZN3JO2 + The sample contains Amfetamine and Caffeine ZZZLCZ + The sample contains amphétamine. Amphétamine is sheduled as illicit drug in France.

Identification methods for Test Sample 2

Legend: S ... used for Screening I ... used for Identification SI ... used for both

RESPONSE SUMMARY FOR TEST SAMPLE 2

Participants: 200

The response summary of all 200 participating laboratories for the identification of SM-2, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample:

Substance Name Number of laboratories: Amfetamine 187

False positives for Test Sample-2:

Round Code: Substance reported: Tech Code: U1ZTV1 1-(3-chlorophenyl) piperazine 150/160 UHQQQQ Temazepam 231 Y767IJ Heroin 150 A6PUUR 2C-B 180/231 RH2SB2 Cocaine 180/190

False negatives for Test Sample-2 (techniques(s) used for ANP): Round Code: Tech Code: IIRJKB 180/190 L7I3D7 180 U1ZTV1 150/160 Y767IJ 150 A6PUUR 180/231 4PADXD 180/190 6UM7YE 180/190 PFLXB1 150 RYRRRO 180 YQDKTM 150/180 YRMRRY 180 FNXHHJ ANP UHQQQQ ANP 3X0JH3 ANP

Z-Scores for Test Sample 2

Amfetamine Amfetamine Deviation Deviation Code Concentration Code Concentration from robust z-score from robust z-score (mass%) (mass%) average average 1M08A3 0.1 -5.4 -8.5 OZEL9J 5.5 0.0 0.0 6Y22ZW 1.8 -3.7 -5.8 2PSK77 5.6 0.0 0.0 QA3IQQ 1.9 -3.6 -5.7 AZ4PMC 5.6 0.1 0.1 TCRCCF 4.0 -1.5 -2.4 DFLSLL 5.6 0.1 0.1 8LC91S 4.0 -1.5 -2.4 6AN2C2 5.6 0.1 0.1 YJOK1X 4.3 -1.3 -2.0 A4YOTY 5.7 0.2 0.3 SSNSSS 4.4 -1.1 -1.8 G6HDDD 5.7 0.2 0.3 TCJ8LF 4.5 -1.0 -1.6 KVYCOZ 5.7 0.2 0.3 2QBODQ 4.5 -1.0 -1.6 HRY21A 5.7 0.2 0.3 F7HCHW 4.6 -0.9 -1.4 8NOHFT 5.7 0.2 0.3 L69LUL 4.7 -0.8 -1.3 EP44XZ 5.7 0.2 0.3 XJ7ZFQ 4.8 -0.8 -1.2 GLGABM 5.7 0.2 0.3 LDL46L 4.8 -0.7 -1.1 LIIPOC 5.7 0.2 0.3 IHPP3A 4.9 -0.6 -1.0 KR7NVL 5.8 0.3 0.4 578QI0 4.9 -0.6 -0.9 INNAMX 5.8 0.3 0.4 YZ1O11 5.0 -0.5 -0.8 LMIMMX 5.8 0.3 0.4 VYHLIW 5.0 -0.5 -0.8 TW8WWT 5.8 0.3 0.4 RYT9EQ 5.0 -0.5 -0.8 G0W6IH 5.9 0.4 0.5 YVZNNK 5.0 -0.5 -0.8 FFRV63 5.9 0.4 0.6 35GJ4P 5.0 -0.5 -0.8 CCTTCS 5.9 0.4 0.6 ABD4CQ 5.0 -0.5 -0.8 DLBGLV 5.9 0.4 0.6 HS1APR 5.0 -0.5 -0.8 KKNZEW 5.9 0.4 0.6 XPESEF 5.0 -0.5 -0.8 B4PKM0 5.9 0.4 0.6 WWKYWV 5.0 -0.5 -0.8 PPHPXW 6.0 0.5 0.7 TKUTMR 5.1 -0.4 -0.7 8OZNNH 6.0 0.5 0.7 YZYVX7 5.1 -0.4 -0.7 6O6Z2R 6.0 0.5 0.7 XXZXFD 5.1 -0.4 -0.7 TFIEH5 6.0 0.5 0.7 JNJCC0 5.1 -0.4 -0.7 1Q2SHP 6.0 0.5 0.7 6UNASW 5.1 -0.4 -0.7 TATTTH 6.1 0.6 0.9 J1DF1H 5.1 -0.4 -0.6 ETWSUN 6.2 0.7 1.1 DXL6MM 5.2 -0.3 -0.5 RRRFMH 6.3 0.8 1.2 8PPPNP 5.2 -0.3 -0.5 HJID9R 6.3 0.8 1.2 QJSIBS 5.2 -0.3 -0.5 OK9VLQ 6.5 1.0 1.6 OWWFR9 5.3 -0.3 -0.4 ZM999M 6.8 1.3 1.9 XVF202 5.3 -0.2 -0.4 YX6UOI 6.8 1.3 2.0 DXFKNP 5.3 -0.2 -0.3 CWI43Z 7.0 1.5 2.3 CIVU6Z 5.4 -0.2 -0.3 BVCWMH 7.0 1.5 2.3 KJUH9B 5.4 -0.1 -0.2 61CSWE 7.0 1.5 2.3 PVVR87 5.4 -0.1 -0.2 GY666S 7.3 1.8 2.8 UBB6JU 5.4 -0.1 -0.2 GLXRWX 8.0 2.5 3.9 466G6Q 5.4 -0.1 -0.2 W2WK2G 8.3 2.8 4.3 3V331Z 5.4 -0.1 -0.2 JYLDDO 9.0 3.5 5.4 GMMUMM 5.4 -0.1 -0.2 BPKXUS 9.5 4.0 6.2 BBQPBH 5.4 -0.1 -0.2 WWT4QM 10.0 4.5 7.0 Q20FHM 5.4 -0.1 -0.2 EHHHXU 11.4 5.9 9.2 FMSMPJ 5.4 -0.1 -0.2 UK1I4W 23.0 17.5 27.4 NY3811 5.5 0.0 -0.1 VQI99W 55.1 49.6 77.7 BI7ICF 5.5 0.0 -0.1 EGPGL2 5.5 0.0 0.0 RSWBPX 5.5 0.0 0.0 42YCFB 5.5 0.0 0.0

Robust average = 5.5 % Round: 2017/2 UNODC value = 5.6 % Substance: SM-2; Amfetamine

4.00 3.9

3.00 2.8 2.3 2.3 2.3 2.0 2.00 1.9 1.6 1.2 1.2 1.1

1.00 0.9 0.7 0.7 0.7 0.7 0.7 0.6 0.6 0.6 0.6 0.6 0.5 0.4 0.4 0.4 0.4 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.1 0.1 0.1 0.0 4.3 5.4 6.2 7.0 9.2 27.4 77.7 0.00 8.5 5.8 5.7 0.0 0.0 0.0 0.0 - - - 0.1 0.1 0.2 - - 0.2 0.2 0.2 0.2 0.2 0.2 0.2 - 0.2 ------0.3 - 0.3 - 0.4 - - 0.4 - 0.5 0.5 0.5 - - - 0.6 - 0.7 0.7 0.7 0.7 0.7

-1.00 - - - - - 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 ------0.9 1.0 - - 1.1 - 1.2 1.3 - - 1.4 - 1.6 1.6 - -

-2.00 1.8 - 2.0 - 2.4 2.4 - - -3.00

-4.00 L L S F 0 1 P BI7ICF LIIPOC QJSIBS TCJ8L DFLSLL TFIEH5 JNJCC0 HJID9R OZEL9J LDL46 L69LU XPESEF 8LC91S SSNSS XJ7ZFQ 578QI CIVU6Z IHPP3A 35GJ4 YJOK1X 2PSK77 EP44XZ YZYVX7 J1DF1H 42YCFB FFRV63 CCTTCS XVF202 3V331Z YX6UOI TCRCCF XXZXFD GY666S YZ1O1 JYLDDO KJUH9B NY3811 TATTTH CWI43Z RYT9EQ PVVR87 UBB6JU EGPGL2 A4YOTY KR7NVL DLBGLV 6O6Z2R BPKXUS HS1APR 8PPPNP VYHLIW KVYCOZ HRY21A DXFKNP 6AN2C2 1Q2SHP UK1I4W YVZNNK 466G6Q OK9VLQ 6Y22ZW QA3IQQ 8NOHFT 61CSWE VQI99W G0W6IH BBQPBH 1M08A3 ABD4CQ FMSMPJ AZ4PMC B4PKM0 RSWBPX INNAMX TKUTMR KKNZEW GLXRWX EHHHXU 8OZNNH PPHPXW RRRFMH G6HDDD Q20FHM ETWSUN F7HCHW 2QBODQ GLGABM ZM999M 6UNASW DXL6MM LMIMMX OWWFR9 W2WK2G BVCWMH TW8WWT WWKYWV WWT4QM GMMUMM z-scores can be interpreted by participants in line with ISO 13528:2005, secion 7.4.2 and ISO/IEC guide43-1:1997(E) as follows: IzI < 2 = satisfactory 2 ≤ IzI ≤ 3 = questionable IzI > 3 = unsatisfactory Accordig to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z- score is considered to give a warning signal. A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occured that requires inverstigation.

57 Z-Score Report per Sample per Substance

Round: 2017/2 Substance: SM-2; Amfetamine

Dispersion of z-scores using different analytical techniques for the quantification of Amfetamine in 2017/2 SM-2

10.0

8.0

6.0

4.0

2.0

0.0

-2.0

-4.0

-6.0

-8.0 HPLC HPLC GC-FID GC-FID GC-MSGC-MS/LC-MS NMR + LC/MS -10.0

Sample 3 Analysis

Identified substances for Test Sample 3

Code Identified Substances 11IFBZ Methamfetamine 1M08A3 Metanfetamine 1Q2SHP metamfetamine 1X1DOB metamfetamine 22FT2U Methamphetamine 2DZZAA metanphetamine 2JEC6G metamfetamine 2NP2F2 metamfetamine 2PSK77 Metamfetamine 2QBODQ Metamfetamine 351XUF l-METANFETAMINA 35GJ4P Metamfetamine 3JP0F0 Metamfetamine 3SM8IQ Metamphetamine 3TSMST Methamphetamine 3V331Z Methamphetamine 3X0JH3 Metanfetamina 42YCFB Methamphetamine 466G6Q Methamphetamine 4PADXD metamphetamine 513NM1 Methamphetamine and Caffeine 578QI0 metamphetamine 5G9GGA Methamphetamine 61CSWE metamfetamine 666ZAW methamfetamine 6AN2C2 Methylamphetamine 6O6Z2R Methamphetamine 6RBI63 metamphetamine 6UM7YE Metamfetamine 6UNASW Metamfetamine 6Y22ZW Methamphetamine 8LC91S Methylamphetamine 8NOHFT metamphetamine 8OZNNH Methamphetamine 8PPE6P metamfetamine 8PPPNP Methamphetamine 966O36 metamfetamine 99Y9E4 Metamfetamine A4YOTY Metamfetamine A6PUUR METAMFETAMINE,D-LACTOSE

Code Identified Substances ABD4CQ Methylamphetamine hydrochloride AE3FR3 metamphetamine AFUTFF METAMPHETAMINE AO0IAA Methamfetamine AZ4PMC Methamphetamine B4PKM0 METAMPHETAMINE B7VEKK Metamfetamine BBQPBH Methamphetamine BI7ICF METAMFETAMINE BOVSZV Metamfetamine BPKXUS Metamfetamine BVCWMH metamphetamine CAZGVF Methamphetamine CCTBNI Metamfetamine CCTTCS Methylamphetamine CFCSQ9 Metamfetamine CIVU6Z Metamphetamine CNOAFA METHAMPHETAMINE CQ8ETV Metamfetamine CQV27N Metamphetamine CWI43Z Methylamphetamine DE2UO1 Methamfetamine DFLSLL methamphetamine DLBGLV Metamfetamine DW1X31 Methamphetamine DXFKNP methamphtamine DXL6MM Methamphetamine E6IWWC Methamphetamine EEEYMJ methamphetamine EGPGL2 Metamfetamine EHHHXU methamphetamine EP44XZ Methamphetamine ERZARV Metamfetamine ETWSUN Metamfetamine F1K811 Methamphetamine F7HCHW Metamfetamine 40.1 % FBZL7G metamphetamine FDFGFF Metamfetamine FFRV63 Metamfetamine FMM8M2 ninguno FMSMPJ Methamphetamine HCl FNXHHJ Methamphetamine FV2JQI Metamfetamina G0W6IH metamfetamine

Code Identified Substances G6HDDD Methamphetamine GLGABM Metamfetamine GLXRWX METAMFETAMINE GMMUMM methamfetamine GY666S Methamphetamine and Caffeine HJID9R metamfetamine HMHSGW Metamphetamine HRY21A METHAMPHETAMINE HS1APR METAMFETAMINE I34AKK metamfetamine IHPP3A Metamfetamine IIRJKB Methamphetamine IJK6H6 metamfetamine IKM3NM METANFETAMINE J1DF1H Methamphetamine JGFGUS METHAMPHETAMINE JNJCC0 Metamphetamine JVVOZV Methamphetamine JYLDDO metamfetamine KCUSOU Metamfetamine KJUH9B Metamfetamine KKNZEW Methamphetamine KR7NVL METHAMPHETAMINE KVYCOZ 0(7$0)(7$0ø1 KYRYY5 Metamfetamine L69LUL Metamfetamine HCl L7I3D7 Methamphetamine LCKOL9 this sample contains Metamfetamine LDL46L Metamfetamine LFFAAE metamfetamine LICCBC Methamphetamine LIIPOC Methylamphetamine LMIMMX Metamfetamine LW5ETC Methamphetamine LXWXMB METAMPHETAMINE MGGBMM Metamfetamine MMRVDM methamphetamine MZIUPW METAMFETAMINE N888E4 metanfetamina, cocaína NUUUZ3 Methamphetamine NY3811 metamfetamine NYIIMJ Metamfetamine O4B4EZ Methamphetamine OCDXEB Methamphetamine

Code Identified Substances OK9VLQ Methamphetamine OOQANA Metamfetamine OUUFRA METHAMPHETAMINE OWWFR9 Metamphetamine hcl OZEL9J metamfetamine P9VJ99 Methamphetamine PBP772 metamfetamine PFLXB1 Metamfetamine PNOHDD Metamfetamine and lactose PPHPXW Methamphetamine PVVR87 Methylamphetamine Q14S11 Metamfetamine Q20FHM Metamfetamine Q4XQI4 Methamphetamine QA3IQQ metamfetamine QBC668 Methamphetamine QG9KLD Metamfetamine QJSIBS Methylamphetamine QVJ4GE Methamphetamine RH2SB2 Metanfetamine RJQT3B Methamphetamine RNRTQ7 metamfetamine RRRFMH Metanfetamina RSWBPX metamfetamine RYRRRO METAMFETAMINE RYT9EQ metamfetamine S4CLU9 Metamfetamine SQ00PF Metamfetamine and Lactose SSNSSS Methamphetamine T5ZGNF Methamphetamine TATTTH methamphetamine HCl TCJ8LF Metamfetamine TCRCCF Metamphetamine TDYBWE Methamphetamine TFIEH5 Metamfetamine TIHNPE Methamphetamine TJGBER Methamphetamine TKUTMR metamfetamine TTT7VV METHAMPHETAMINE, LACTOSE TTT83P Methamphetamine TW8WWT Metamfetamine TYHGZT Methamphetamine U1ZTV1 Methamphetamine U3LUJU metamfetamine

Code Identified Substances UBB6JU Metamfetamine UHQQQQ Methamphetamine and phentermine UK1I4W Methamphetamine VHOLZ9 methamphetamine VNAAG2 Methamphetamine VQI99W METAMFETAMINE VYHLIW Metamfetamine W2WK2G Methamphetamine WWKYWV Methamphetamine WWT4QM methamphetamine XGWDIY methamphetamine XJ7ZFQ Metamfetamine XPESEF Methamphetamie XVF202 Methamphetamine Hydrochloride XXZXFD Methamphetamine Y767IJ Méthafetamine YJOK1X Metamfetamine YQDKTM METHAMPHETAMINE YRMRRY Metamfetamine YVZNNK Methylamphetamine YX6UOI METHAMPHETAMINE YZYVX7 Methamfetamine Z3CTND Metamfetamine ZM999M Methamfetamine ZN3JO2 Metamfetamine ZZZLCZ Méthamphétamine

Statement of findings for Test Sample 3

Code Lactose Metamfetamine 11IFBZ ANP + Presence of Methamfetamine was confirmed qualitatively 1M08A3 ANP + Powder containing Metanfetamine hydrochloride 27,1% - 33.9% as base 1Q2SHP ANP + Metamfetamine is controlled by law (R.D. of of 6/09/2017 annex IIb) 1X1DOB ANP + Results of screening tests were positive for amfetamines. Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with metamfetamine. 22FT2U - + sample 2017/2/SM-3 was found to contain Methamphetamine 2DZZAA - + The sample corresponds 2JEC6G + + ./. 2NP2F2 + + White powder containing metamfetamine (41,10%ww) and lactose 2PSK77 + +

2QBODQ + +

351XUF - + se identifico la molecula de hidroxilamina como impureza presente 35GJ4P + + The samples contains metamfetamine and lactose. Metamfetamine is scheduled as illicit drug in France. 3JP0F0 ANP + Metamfetamine according colorimetric reactions and gas chromatography/mass spectrometry analysis. 3SM8IQ ANP +

3TSMST - + Test sample 2017/2/SM-3 was confirmed to contain methamphetamine, a DEA Schedule II substance. 3V331Z ANP + The sample contains 38.2 % of methamphetamine . 3X0JH3 ANP + Realizados los ensayos colorimaticos y confiram XXXX dio positiva para metanfetamina 42YCFB + +

466G6Q - + The sample contains methamphetamine. The content of methamphetamine is determined to 52 % (as methamphetaminesulphate). Metamphetamine is a controlled substance in X. 4PADXD - +

Code Lactose Metamfetamine 513NM1 ANP + Nature- Powder Color- White Odor- Odorless 578QI0 + + lactose 5G9GGA + + SM03 was found to contain Methamphetamine and Lactose 61CSWE - + marquis reagent: positive reaction, cobalt thiocyanate: negative result, GC-MS: metmfetamine/compared with library spectrum of metamfetamine, FTIR: lactose, spectrum of ethanol extract residue compared with IR spectrum of lactose) 666ZAW ANP + no more findings 6AN2C2 - + Powder contains methylamphetamine. 6O6Z2R ANP + Analysis of a representative sample of the powder revealed the presence of methamphetamine with a purity of approximately 43% (calculated as base). 6RBI63 + + White powder containing methylamphetamine and lactose 6UM7YE - + The major compound we found in the SM3 sample after GC/MS injection is metamfetamine. 6UNASW + + A white powder which had a net weight of 224 milligrams which contained Methylamphetamine Hydrochloride and lactose, with a methylamphetamine purity of 47% (purity reported as the hydrochloride form of methylamphetamine.) 6Y22ZW + + Methamphetamine was identified in SM-3 and the percentage is 49.95. In addition to that lactose was identified in SM-3. 8LC91S ANP + Methylamphetamine at a purity of 39% 8NOHFT + +

8OZNNH ANP + The sample contains methamphetamine (40.2%). 8PPE6P ANP + White powder containing metamfetamine 8PPPNP + in Austria illegal drug according to the law 966O36 + +

99Y9E4 ANP + The analyzed sample contain Methamphetamine A4YOTY + + Presence of metamfetamine hydrochloride and lactose was detected in the sample. A6PUUR + + ONE MILIGRAM OF THE SAMPLE WAS WEIGHTED AND DILUTED IN 10ML OF METHANOL THEN IT WAS INJECTED DIRECTY BY CG-MS

Code Lactose Metamfetamine ABD4CQ + + One brown glass bottle with a screw-top lid which contained white powder. This powder weighed 226 milligrams and was found to contain an average of 50% METHYLAMPHETAMINE HYDROCHLORIDE, along with LACTOSE. Methylamphetamine hydrochloride is a Class A controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). AE3FR3 + + Lactose was also identified in trace amount. AFUTFF ANP + The sample contains Metamphetamine. AO0IAA + + Also it was found as a diluent: lactose. AZ4PMC ANP +

B4PKM0 ANP + 1971 CONVENTION ON PSYCHOTROPIC SUBSTANCES. UN (LIST II) B7VEKK ANP + On 2017/2/SM-3 Metamfetamine was detected. BBQPBH ANP + One glass bottle containing 0.27 grammes of a powder containing 0.08 grammes of methamphetamine. BI7ICF + + METAMFETAMINE in LACTOSE powder BOVSZV ANP +

BPKXUS ANP + - BVCWMH ANP +

CAZGVF - + On analysis, I found the sample 'SM-1' containing Methamphetamine CCTBNI ANP + Sample 2017/2/SM-3 found to contain Metamfetamine CCTTCS - +

CFCSQ9 ANP +

CIVU6Z + + Metamphetamine hydrochloride 39.25%. The test sample contained LACTOSE CNOAFA ANP + Test sample represents white powder that contains methamphetamine (controlled drug). CQ8ETV + + SM-3 contains metamfetamine and lactose CQV27N ANP + caffeine

Code Lactose Metamfetamine CWI43Z ANP + The above article was examined and found to consist of a glass vial containing a quantity of white powder. The powder, which was not weighed, was analysed and found to contain Methylamphetamine.

Methylamphetamine is a class A controlled drug within the provisions of the Misuse of Drugs Act 1971. DE2UO1 ANP + -The sample obtains with the positive result with Marquis reagent - TLC The Rf sample obtain with the same Rf Methamfetamine standard -Gc The Rt sample obtain with the same Rt Methamfetamine standard DFLSLL + + white powder containing methamphetamine and lactose as diluent DLBGLV - +

DW1X31 + + Methamphetamine in the ratio of %39 was detected in sample 3. DXFKNP - + a substance identified is methamphtamine DXL6MM ANP + GC/MS analysis showed for the presence of methamphetamine. E6IWWC ANP +

EEEYMJ ANP + methamphetamine EGPGL2 + + It has been detected the presence of metamfetamin in the sample EHHHXU + + On analysis, I found that the white powdery substances contain 37.8%w/w of methamphetamine EP44XZ + + The sample contained 47.3% of methamphetamine and additionally lactose. ERZARV - + The test sample 2017/2/SM-3 was found to contain the controlled drug metamfetamine. ETWSUN + + This sample is metamfetamine. F1K811 ANP + Based on the above analysis, the sample was found to contain methamphetamine F7HCHW - +

FBZL7G ANP +

FDFGFF + + Was found Metamfetamine and Lactose. FFRV63 + + Lactose FMM8M2 ANP + Metanfetamina FMSMPJ + + Methamphetamine 40.25% as base and Lactose

Code Lactose Metamfetamine FNXHHJ ANP + Examination of the Powder SM-3 revealed the presence of controlled drugs methamphetamine FV2JQI - + in the analysis was obtained (Metamfetamina) controlled substance G0W6IH + + metamfetamine and lactose G6HDDD + + The sample contains Lactose GLGABM + + lactose GLXRWX + +

GMMUMM - + methamfetamine GY666S - + We found Methamphetamine and Caffeine by GCMS analysis. HJID9R - + we can not quantify metamfetamine HMHSGW ANP + The sample SM-3 contains Metamfetamine. HRY21A + + LACTOSE HS1APR + +

I34AKK ANP +

IHPP3A + + Sample contained Metanfetamine as hydrochloride and LACTOSE. Identification of Metanfetamine by FTIR, HRMN and GC/MS, quantification by GC/FID. Identification of LACTOSE by FTIR, HRMN and Colorimetric Reactions (Molish Test). IIRJKB - + Using the techniques CR, TLC, GC-MS, sample SM-3 was found to contain Methamphetamine. IJK6H6 ANP + Examination and analyses performed on the solid in SM-3 showed it to contain metamfetamine ( a central stimulant) IKM3NM + + METANFETAMINE INNAMX + +

J1DF1H + + Sample also contain lactose. The presence of drug confirmed by GC-MS, FTIR spectroscopy and HPLC-DAD.The hydrochloride form of methamphetamine was confirmed by the anion analysis and FTIR spectroscopy. JGFGUS ANP + Sample 2017/2/SM-3 a white powder gave a positive result for Methamphetamine, substance under national legislation on drugs JNJCC0 + + The sample contains Lactose

Code Lactose Metamfetamine JVVOZV ANP + SM-3 to contained Methamphetamine JYLDDO + + SM3 contains 38% (w/w) metamfetamine base with lactose. KCUSOU ANP + It was detected the presence of Metamfetamine in the sample analysed. KJUH9B + + The powder contains 38.4 ± 2.4 % (w/w) metamfetamine-base. The sample also contained lactose. KKNZEW - + The sample contains 39,4 % of methamphetamine (free base) KR7NVL + + The sample contains methamphetamine and lactose KVYCOZ - +

KYRYY5 + + It also contains lactose L69LUL + + SM3 contains Metamfetamine and Lactose, with a concentration of 40.54% Metamfetamine base. L7I3D7 + + SM3 contains Methamphetamine and also lactose. LCKOL9 ANP + Confirmed by GC MS LDL46L - +

LFFAAE - + STIMULANT LICCBC ANP + The sample was found to contain 38.9% of methamphetamine (as base). LIIPOC - + Item 2017/2/SM-3 was found to contain Methylamphetamine which is a class A controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended) at a purity of 36.5%. LMIMMX - + %39,5 Metamfetamine LW5ETC + + Methamphetamine+lactose LXWXMB + + It was identificated metamphetamine and lactose in SM-3 sample. MGGBMM ANP + White powder sample analyzed contains Metamfetamine MMRVDM + + lactose MZIUPW + + METAMFETAMINE + LACTOSE HYDROCHLORIDE FORM N888E4 + + metanfetamina cocaina NUUUZ3 + + Test sample 2017/2/SM-3 contains Methamphetamine. It also contains Lactose.

Code Lactose Metamfetamine NY3811 + +

NYIIMJ + + the sample contains Metamfetamine O4B4EZ ANP + Satisfied with result obtained OCDXEB + + The quemical tests and the concidence in the time of retention and mass fragmentogram with the material of reference used in the same conditions that the analyzed sample, they indicate in this one the Methamphetamine presence. OK9VLQ + + Methamphetamine is on the list of drugs. OOQANA ANP + The sample 2017/2/SM-3 was found to contain Metamfetamine. OUUFRA + + LACTOSE IS FOUND OWWFR9 + + Metamphetamine hcl and Lactose. Purity base metamphetamine 38,6% (w/w) OZEL9J + + lactose P9VJ99 ANP + That I examined and analysed the said sample and found it to contain: controlled substance(s) within the meaning of the Controlled Drug and Substances Act: Schedule I 18. Methamphetamine (N,alpha-Dimethylbenzeneethamamine)

That I examined and analysed the said sample and found it to contain: controlled substance(s) within the meaning of the Controlled Drug and Substances Act: Schedule I 18. Methamphetamine (N,alpha-Dimethylbenzeneethamamine) calculated as the hydrochloride 42% (w/w) PBP772 ANP + Sample 2017/2/SM-3 found to contain 39.3% metamfetamine PFLXB1 + + Sample 2017/2/SM-3 consists of white powder. Metamfetamine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample. PNOHDD + + We analized the sample by FTIR and GC-MS. We could identify lactose by colourimetric test. The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard. PPHPXW - +

PVVR87 ANP + Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971 Q14S11 - + The result of the test of SM-3 (31) received has confirmed that the mentioned sample contained Metamfetamine but we are not able to give a quantification result. Q20FHM + + lactose Q4XQI4 + + no specially comment lactose found on insoluble MeOH QA3IQQ ANP + White powder containing metamfetamine (36.0%ww) which is controlled by national law

Code Lactose Metamfetamine QBC668 ANP + White powder containing methamphetamine QG9KLD ANP + Sm-3 was found to contain metamfetamine. QJSIBS + + This vial was found to contain 217 milligrams of a white powder. This powder was found to contain 37.6% Methylamphetamine. Methylamphetamine is controlled as a Class A drug under the Misuse of Drugs Act 1971 (as amended). QVJ4GE ANP + The sample contains methamphetamine which is Amfetamine Type Stimulants. RH2SB2 + +

RJQT3B ANP + White sample analysed by GC/MS was found to contain Methamphetamine. Sample Mass Spectrum was similar to reference material. RNRTQ7 ANP +

RRRFMH - +

RSWBPX ANP + Metamfetamine was detected by GCMS and quantified by GCFID RYRRRO ANP +

RYT9EQ + + After chemical analysis performed the sample contents: 1/metamfetamine 2/ Lactose S4CLU9 + + Lactose SQ00PF + + The Test sample 2017/2/SM-3 was analyzed by Thin Layer Chromatography technique and was found to contain Metamfretamine and Lactose. SSNSSS + +

T5ZGNF ANP + That I examined and analysed the said sample and found it to contain: controlled substance(s) within the meaning of the Controlled Drugs and Substances Act: Schedule I 18. methamphetamine (N,a-dimethylbenzeneethanamine) TATTTH + + lactose TCJ8LF - +

TCRCCF - + white powder colour statement TDYBWE ANP + The white powder was analysed and found to contain methamphetamine. TFIEH5 ANP +

Code Lactose Metamfetamine TIHNPE ANP + The sample was found to contain a controlled substance within the meaning of the Controlled Drugs and Substances Act: Schedule I 18. Methamphetamine (N,Įdimethylbenzeneethanamine). TJGBER - + Table 2 Scedule 2 Narcotic substances (use by medicine), apruved by GD 1088 aat 05.10.2004 RM (last update 27.02.2017 TKUTMR ANP + White powder containing 42.1%ww of metamfetamine TTT7VV + +

TTT83P ANP + From screening test by using (MR) and (Ion scan) and from confirmation test using (GC-MS) the sample was found to contain the controlled drug (Methamphetamine). TW8WWT - +

TYHGZT ANP + Methamphetamine was detected in the sample by GC-MS. U1ZTV1 - + Drug detected using two solvent systems. U3LUJU - +

UBB6JU ANP + Matamfetamine, appr. 41 % UHQQQQ ANP + Presence of Methamphetamine and phentermine was confirmed by LC/MS/MS technique UK1I4W - + Methamphetamine was found in the sample VHOLZ9 + + The sample contains methamphetamine, lactose VNAAG2 ANP + Sample SM-3 was found to contain 39.3 % methamphetamine. VQI99W ANP +

VYHLIW + + Lactose W2WK2G - + Both TLC and GCMS identify Methamphetamine WWKYWV ANP + The sample was found to contain Methamphetamine, a Class A controlled substance under the Misuse of Drugs Act 1971. WWT4QM - + This substance was identified by Marquis Reagent, and using analytical techniques of Gas Chromatography / Mass Spectrometry and Fourier Transform Infrared Spectrometry. And we obtained a quantification of 60,61% using HPLC-DAD techniques. It sample contain Caffeine too like adulterant XGWDIY + + lactose XJ7ZFQ + + The sample consist controlled drugs - Metamfetamine

Code Lactose Metamfetamine XPESEF + + Meth as HCl + lactose XVF202 + + A composite was formed from 1 unit for testing. Methamphetamine hydrochloride and lactose confirmed in the composite. XXZXFD ANP + In the test sample 2017/2/SM-3 was detected methamphetamine Y767IJ - +

YJOK1X + + Lactose is also present. YQDKTM ANP +

YRMRRY ANP + In sample 2017/2/SM-3 was found Metamfetamine YVZNNK - + This powder was found to contain methylamphetamine. Methylamphetamine is a Class B controlled substance under the provisions of the Misuse of Drugs Act 1971 (as amended). YX6UOI ANP +

YZ1O11 ANP +

YZYVX7 ANP + The sample SM-3 contains methamfetamine, 39% Z3CTND - + The sample contains metamfetamine which is listed as a controlled drug according to french order, appendix III of February 22nd 1990. ZM999M + + Methamfetamine was identified by GC-MS & quantified by GC. ZN3JO2 + + The sample contains Metamfetamine and Lactosa ZZZLCZ - + The sample contains méthamphétamine. Méthamphétamine is sheduled as illicit drug in France.

Identification methods for Test Sample 3

Legend: S ... used for Screening I ... used for Identification SI ... used for both

RESPONSE SUMMARY FOR TEST SAMPLE 3

Participants: 200

The response summary of all 200 participating laboratories for the identification of SM-3, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample:

Substance Name Number of laboratories: Methamphetamine 200 Lactose: 81

False positives for Test Sample-3: Round Code: Substance reported: Tech Code: N888E4 Cocaine 171/180

False negatives for Test Sample-3 (techniques(s) used for ANP):

There were no false negative results for SM-3

Frequency of use of screening, identification and quantification techniques:

Response Summary Participants 200 Technique 140 141 142 150 160 161 171 180 190 200 210 211 230 231 Screening (No.) 64 76 56 23 0 1 8 68 17 1 16 1 3 0 (%) 32.8 39.0 28.7 11.8 0.0 0.5 4.1 34.9 8.7 0.5 8.2 0.5 1.5 0.0 Identification (No.) 16 3 3 39 10 11 29 172 76 1 11 2 5 10 (%) 8.2 1.5 1.5 20.0 5.1 5.6 14.9 88.2 39.0 0.5 5.6 1.0 2.6 5.1 Quantification (No.) 0 0 0 0 9 31 56 20 0 0 0 4 1 3 (%) 0.0 0.0 0.0 0.0 8.0 27.4 49.6 17.7 0.0 0.0 0.0 3.5 0.9 2.7

Z-Scores for Test Sample 3 Metamfetamine Metamfetamine Deviation Deviation Code Concentration Code Concentration from robust z-score from robust z-score (mass%) (mass%) average average AZ4PMC 31.72 -7.8 -4.0 VNAAG2 39.3 -0.2 -0.1 P9VJ99 33.8 -5.7 -3.0 JNJCC0 39.4 -0.1 -0.1 1M08A3 33.9 -5.6 -2.9 KKNZEW 39.4 -0.1 -0.1 TFIEH5 35.5 -4.0 -2.1 466G6Q 39.4 -0.1 -0.1 RSWBPX 35.7 -3.8 -2.0 XPESEF 39.42 -0.1 -0.1 GY666S 35.9 -3.6 -1.9 22FT2U 39.46 0.0 0.0 QA3IQQ 36 -3.5 -1.8 G6HDDD 39.5 0.0 0.0 XJ7ZFQ 36.2 -3.3 -1.7 LMIMMX 39.5 0.0 0.0 LIIPOC 36.5 -3.0 -1.6 8PPPNP 39.5 0.0 0.0 XXZXFD 36.9 -2.6 -1.4 BBQPBH 39.5 0.0 0.0 KR7NVL 37 -2.5 -1.3 J1DF1H 39.5 0.0 0.0 B4PKM0 37.2 -2.3 -1.2 NY3811 39.7 0.2 0.1 TCJ8LF 37.3 -2.2 -1.2 CCTBNI 39.8 0.3 0.1 CFCSQ9 37.3 -2.2 -1.2 GMMUMM 39.8 0.3 0.1 TW8WWT 37.3 -2.2 -1.2 INNAMX 39.9 0.4 0.2 6UNASW 37.6 -1.9 -1.0 RYT9EQ 40.0 0.5 0.2 8NOHFT 37.6 -1.9 -1.0 CQ8ETV 40.0 0.5 0.2 QJSIBS 37.6 -1.9 -1.0 42YCFB 40.0 0.5 0.2 DFLSLL 37.7 -1.8 -1.0 ABD4CQ 40.0 0.5 0.2 EHHHXU 37.8 -1.7 -0.9 HS1APR 40.0 0.5 0.2 TATTTH 38 -1.5 -0.8 F7HCHW 40.1 0.6 0.3 JYLDDO 38 -1.5 -0.8 8OZNNH 40.2 0.7 0.3 KVYCOZ 38.2 -1.3 -0.7 YZ1O11 40.2 0.7 0.3 3V331Z 38.2 -1.3 -0.7 Q4XQI4 40.2 0.7 0.4 2QBODQ 38.3 -1.2 -0.6 FMSMPJ 40.3 0.8 0.4 ETWSUN 38.35 -1.2 -0.6 DLBGLV 40.5 1.0 0.5 KJUH9B 38.4 -1.1 -0.6 L69LUL 40.5 1.0 0.5 QVJ4GE 38.53 -1.0 -0.5 A4YOTY 40.6 1.1 0.5 OWWFR9 38.6 -0.9 -0.5 VQI99W 41.0 1.5 0.7 BPKXUS 38.7 -0.8 -0.4 UBB6JU 41.0 1.5 0.7 GLGABM 38.7 -0.8 -0.4 2NP2F2 41.1 1.6 0.8 VYHLIW 38.8 -0.7 -0.4 OK9VLQ 41.4 1.9 1.0 Q20FHM 38.8 -0.7 -0.4 SSNSSS 41.5 2.0 1.0 LICCBC 38.9 -0.6 -0.3 2PSK77 41.6 2.1 1.1 BI7ICF 38.9 -0.6 -0.3 FFRV63 41.7 2.2 1.1 O4B4EZ 38.92 -0.6 -0.3 LDL46L 41.8 2.3 1.2 YZYVX7 39 -0.5 -0.3 DXFKNP 41.9 2.4 1.2 XVF202 39 -0.5 -0.3 TKUTMR 42.1 2.6 1.3 EGPGL2 39 -0.5 -0.3 YJOK1X 42.1 2.6 1.3 OZEL9J 39 -0.5 -0.3 YX6UOI 42.7 3.2 1.6 8LC91S 39 -0.5 -0.3 PPHPXW 43.0 3.5 1.8 JVVOZV 39 -0.5 -0.3 6O6Z2R 43.0 3.5 1.8 578QI0 39.08 -0.4 -0.2 35GJ4P 43.0 3.5 1.8 IHPP3A 39.09 -0.4 -0.2 W2WK2G 44.1 4.6 2.4 1Q2SHP 39.1 -0.4 -0.2 FNXHHJ 45.0 5.5 2.8 CIVU6Z 39.25 -0.3 -0.2 DXL6MM 45.4 5.9 3.0 CCTTCS 39.3 -0.2 -0.1 UK1I4W 46.0 6.5 3.3 PBP772 39.3 -0.2 -0.1 TCRCCF 46.4 6.9 3.5

Metamfetamine Deviation Code Concentration from robust z-score (mass%) average EP44XZ 47.3 7.8 4.0 BVCWMH 47.8 8.3 4.3 6Y22ZW 50.0 10.5 5.4 GLXRWX 52.0 12.5 6.4 S4CLU9 52.6 13.1 6.7 ZM999M 53.8 14.3 7.3 WWT4QM 60.6 21.1 10.8

Robust average = 39.5 % Round: 2017/2 UNODC value = 39.9 % Substance: SM-3; Metamfetamine

4.00 3.5 3.3 3.0

3.00 2.8 2.4

2.00 1.8 1.8 1.8 1.6 1.3 1.3 1.2 1.2 1.1 1.1 1.0 1.0

1.00 0.8 0.7 0.7 0.5 0.5 0.5 0.4 0.4 0.3 0.3 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.1 0.1 0.1 4.0 4.3 5.4 6.4 6.7 7.3 10.8 0.00 4.0 0.0 0.0 0.0 0.0 0.0 0.0 - 0.1 0.1 0.1 0.1 - - - - 0.1 0.1 0.1 0.2 - - - - 0.2 0.2 0.2 0.3 0.3 0.3 0.3 0.3 0.3 - - - 0.3 ------0.3 0.3 - - - 0.4 0.4 - - 0.4 0.4 - - 0.5 0.5 - - 0.6 0.6 - 0.6 - 0.7 0.7 -

-1.00 - - 0.8 0.8 - - 0.9 - 1.0 - 1.0 1.0 1.0 - - - 1.2 1.2 1.2 - - - 1.2 - 1.3 - 1.4 - 1.6 -

-2.00 1.7 - 1.8 - 1.9 - 2.0 - 2.1 -

-3.00 2.9 - 3.0 -

-4.00 L S T 5 0 T X C 9 D Q Q LF W BI7ICF LIIPO QJSIBS TCJ8 DFLSLL TFIEH LICCBC JNJCC0 OZEL9J LDL46L P9VJ99 L69LUL XJ7ZF 8LC91S 578QI0 XPESEF SSNSSS CIVU6Z IHPP3A CCTBNI 35GJ4P 2PSK77 YJOK1X EP44XZ YZYVX7 CCTTCS J1DF1H 42YCFB FFRV63 3V331Z XVF202 YX6UOI S4CLU9 TCRCCF GY666 XXZXF PBP772 22FT2U JYLDDO YZ1O11 Q4XQI4 TATTTH KJUH9B JVVOZV NY3811 2NP2F2 CFCSQ QVJ4GE O4B4EZ RYT9EQ KR7NV BPKXUS EGPGL2 DLBGLV A4YOTY UBB6JU 6O6Z2R FNXHHJ 8PPPNP HS1APR KVYCOZ VYHLIW CQ8ETV DXFKNP 1Q2SHP UK1I4W 466G6Q OK9VLQ QA3IQ 6Y22ZW 8NOHF VQI99W BBQPBH AZ4PMC 1M08A3 B4PKM ABD4CQ FMSMPJ RSWBP VNAAG2 INNAMX EHHHXU KKNZEW TKUTMR GLXRWX 8OZNNH PPHPXW G6HDDD ETWSUN Q20FHM F7HCHW 2QBODQ GLGABM ZM999M 6UNAS LMIMMX DXL6MM OWWFR9 W2WK2G BVCWMH TW8WW WWT4QM GMMUMM z-scores can be interpreted by participants in line with ISO 13528:2005, secion 7.4.2 and ISO/IEC guide43-1:1997(E) as follows: IzI < 2 = satisfactory 2 ≤ IzI ≤ 3 = questionable IzI > 3 = unsatisfactory Accordig to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z- score is considered to give a warning signal. A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occured that requires inverstigation.

83 Z-Score Report per Sample per Substance

Round: 2017/2 Substance: SM-3; Metamfetamine Dispersion of z-scores using different analytical techniques for the quantification of metamfetamine in 2017/2 SM-3

0 Title

-2

-4

-6

-8 HPLC GC-FID GC-MS NMR + LC/MS HPLC GC-FID GC-MS -10

Sample 4 Analysis

Identified substances for Test Sample 4

Code Identified Substances 1M08A3 none 1Q2SHP no drugs 22FT2U - 2DZZAA no detecte 2NP2F2 -- 35GJ4P none 3TSMST None 466G6Q Possibly cellulose 513NM1 No 5G9GGA None 61CSWE - 666ZAW NO DRUGS FOUND 6AN2C2 None detected 6RBI63 -- 8OZNNH None 8PPE6P -- 8PPPNP none B7VEKK None BPKXUS - CCTBNI none CNOAFA NONE CQ8ETV Not found CWI43Z Negative for Controlled Drugs DXFKNP non-drug substance DXL6MM - FDFGFF None FFRV63 no FMM8M2 ninguno FMSMPJ None G6HDDD Blank GMMUMM - GY666S No drug HJID9R we didn't find any substance IIRJKB Not Applicable J1DF1H None JGFGUS - JNJCC0 Blank KJUH9B - KKNZEW no illegal substances L7I3D7 none

Code Identified Substances LIIPOC N/A LW5ETC - LXWXMB No drugs MGGBMM None MZIUPW - NUUUZ3 None. O4B4EZ No drugs detected OK9VLQ / OOQANA Nil OUUFRA NA PNOHDD blank QA3IQQ -- QG9KLD No drugs QVJ4GE No drugs found RJQT3B None RSWBPX -- SQ00PF None SSNSSS No TCRCCF Oleamide U1ZTV1 None detected. U3LUJU blank UK1I4W no drugs found VHOLZ9 - W2WK2G Negative WWKYWV None WWT4QM NOT FOUND XPESEF no drugs YRMRRY none YVZNNK N/A ZZZLCZ none

Statement of findings for Test Sample 4

Code [blank sample] 11IFBZ No substance from ICE menu 2017/02/SM was detected 1M08A3 herbal product. No controlled substances found 1Q2SHP 1X1DOB 22FT2U - 2DZZAA 2JEC6G 2NP2F2 green powder not containing any listed substance 2PSK77 2QBODQ 351XUF no se identifica ninguna sustancia controlada es una planta natural 35GJ4P Any compounds were detected. It seems to be a powder made from a plant. 3JP0F0 Not detected drugs according colorimetric reactions and gas chromatography/mass spectrometry analysis. 3SM8IQ It seems like an aromatic plant 3TSMST Test sample 2017/2/SM-4 does not contain any controlled substances. 3V331Z 3X0JH3 A los ensayos realizados dio negativo 42YCFB 466G6Q The sample is not identified. Is is, with the methods applied, not identified any controlled substances. 4PADXD 513NM1 Nature- Powder Color- Greenish Yellow Odor- Odorless 578QI0 5G9GGA SM03 is a blank containing starch 61CSWE plant material, no substance of importance (for example eucalyptol 666ZAW No other substances was found 6AN2C2 No controlled drugs detected. 6O6Z2R A representative sample of the powder was analysed for the presence of a range of commonly encountered controlled drugs; none were detected. 6RBI63 light green powder, grass smelling, not containing controlled drugs 6UM7YE We found no subbstances placed under control in the SM4 sample after GC/MS injection. No controlled drugs in this SM4 sample. 6UNASW A green herbal powder which had a net weight of 226 milligrams which was found to be negative for controlled substances. 6Y22ZW Controlled drugs were not identified in SM-4. 8LC91S 8NOHFT 8OZNNH No controlled drugs detected.

Code [blank sample] 8PPE6P green sample not containing any controlled substance 8PPPNP no drug 966O36 99Y9E4 The analyzed sample does not contain narcotic or psychotropic substances A4YOTY Presence of substances from the ICE menu was not detected in the sample. Blank test sample is plant powder. A6PUUR ONE MILIGRAMO OF THE SAMPLE WAS WEIGHTED AND DILUTED IN 10 ML OF METHANOL. THEN IT WAS INJECTED DIRECTY BY CG-MS ABD4CQ One brown glass bottle with a screw-top lid which contained finely ground green herbal material. This material weighed 229 milligrams. No controlled drugs were detected in this material. AE3FR3 AFUTFF No controlled substance detected. AO0IAA It was found by FTIR that could contain a vegetable plant: sisal. AZ4PMC B4PKM0 B7VEKK On 2017/2/SM-4 neither drug was detected. BBQPBH One glass bottle containing 0.23 grammes of a plant material which did not contain any substances controlled under the Dangerous Drugs Ordinance (Cap. 134). BI7ICF BOVSZV BPKXUS - BVCWMH presence of THC analyzed by LCMSMS CAZGVF CCTBNI No drugs detected on sample 2017/2/SM-4 CCTTCS CFCSQ9 CIVU6Z CNOAFA Test sample represents herbal green powder that contains no drug under control. CQ8ETV SM-3 does not contain any substances from ICE Menu. CQV27N CWI43Z The above article was examined and found to consist of a glass vial containing a quantity of vegetable material. The vegetable material, which was not weighed, was analysed for the presence of controlled drugs within the Misuse of Drugs Act 1971 with a negative result. DE2UO1 DFLSLL no drugs detected DLBGLV DW1X31 No drugs were detected in sample 4. DXFKNP a substance identified is non-drug substance DXL6MM GC/MS analysis didnt show any result. E6IWWC no any narcotic, psychotropic substance and precursore identified on test sample no: 4 EEEYMJ EGPGL2 It has not been detected any drug in the sample

Code [blank sample] EHHHXU Unable to identify the controlled drugs. EP44XZ No controlled substances were detected in the sample. ERZARV The test sample 2017/2/SM-4 do not found to contain any controlled drugs. ETWSUN This sample does not contain drugs. F1K811 Based on the above analysis, the sample was found to not contain any controlled drugs. F7HCHW FBZL7G FDFGFF We have not found any drug. FFRV63 no FMM8M2 ninguno FMSMPJ None of drugs found FNXHHJ Examination of the Powder SM-4 did not reveal the presence of any controlled drugs. FV2JQI in the analysis was not obtained controlled substance G0W6IH glucose and sorbitol G6HDDD Blank GLGABM GLXRWX GMMUMM - GY666S We found no drug and substance that is in the menu of ICE programme HJID9R HMHSGW In the sample SM-4 was not found controlled substance. HRY21A HS1APR I34AKK IHPP3A No drug detected by FTIR and GC/MS.

IIRJKB Nil IJK6H6 Examination and analyses performed on the solid in SM-4 did not reveal the presence of dangerous drugs IKM3NM NO CONTROLLED SUBSTANCE IS FOUND INNAMX J1DF1H Propably natural plant material. JGFGUS Sample 2017/2/SM-4 a green powder gave a negative result for substances under national legislation on drugs JNJCC0 Blank JVVOZV No dangerous drugs detected in SM-4 JYLDDO KCUSOU The substances that were tested for weren´t found to be present in the sample analysed. KJUH9B No controlled substances were detected KKNZEW No illegal substances were found KR7NVL The sample does not contain controlled substances

Code [blank sample] KVYCOZ KYRYY5 The sample does not contain drugs L69LUL SM4 is a blank sample, it doesn't contain substances from the ICE menu. L7I3D7 none LCKOL9 This sample was tested by gc ms and no illict compound was found LDL46L LFFAAE LICCBC The sample was analysed and no common controlled drug was detected. LIIPOC No controlled drugs were detected in item 2017/2/SM-4 LMIMMX LW5ETC Blanck LXWXMB It was not detected any psychotropic or narcotic drug in SM-4 sample. The SM-4 was identificated as plant material. MGGBMM Green powder sample analyzed does not contain any controlled substances MMRVDM MZIUPW N888E4 NUUUZ3 Test sample 2017/2/SM-4 does not contain any dangerous drugs. However, it contains Glucose. NY3811 NYIIMJ NON-CONTROLLED SUBSTANCE O4B4EZ No drugs detected OCDXEB The not concidence in the time of retention and mass fragmentogram with the material of reference used in the same conditions that the analyzed sample, indicates the not detection of studied analytes. OK9VLQ There are no drugs in the samples. OOQANA The sample 2017/2/SM-4 was found to contain NO NARCOTIC DRUG. OUUFRA no se encontraron sustancias controladas OWWFR9 OZEL9J vitamine E P9VJ99 That I examined and analysed the said sample and was unable to identify a substance within the meanuing of the Controlled Drugs and Substances Act or the Prescription Drug List as define in section A.01.010 of the Food and Drugs Act. PBP772 No controlled drug was found in the sample 2017/2/SM-4 PFLXB1 Sample 2017/2/SM-4 consists of green powder. No prohibited substances are detected in this sample. PNOHDD We analized the sample by FTIR and GC-MS. We couldn´t identify any substance in the ICE PROGRAM. The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard PPHPXW PVVR87 Q14S11 We have not found any controlled drug in SM-4 (31). Q20FHM Q4XQI4 no commet

Code [blank sample] QA3IQQ the greenish podwer does not contain substances under control by national law QBC668 Green powder-No controlled substances detected QG9KLD Sm-4 was found not to contain any drugs. QJSIBS This vial contained 224 milligrams of a green herbal material. This herbal material was found to contain no controlled drugs. QVJ4GE There is no drugs found in this sample RH2SB2 RJQT3B No controlled substance was identified by GC/MS in the sample. RNRTQ7 RRRFMH RSWBPX -- RYRRRO RYT9EQ S4CLU9 SQ00PF The Test sample 2017/2/SM- 4 was analyzed by Thin Layer Chromatography technique and was found not to contain Listed drugs. SSNSSS T5ZGNF That I examined and analysed the said sample and was unable to identify a substance within the meaning of the Controlled Drugs and Substances Act or the Prescription Drug List as defined in section A.01.010 of the Food and Drug Regulations. TATTTH blank sample TCJ8LF TCRCCF black-green-brown colour powder statement TDYBWE The vegetable matter was analysed for controlled substances with a negative result. TFIEH5 TIHNPE The sample was examined and analysed and was unable to identify a substance within the meaning of the Controlled Drugs and Substances Act or the Prescription Drug List as defined in section A.01.010 of the Food and Drug Regulations. TJGBER TKUTMR green powder not containing any common controlled drug TTT7VV TTT83P TW8WWT Plant material- cellulose identified TYHGZT Using the GC-MS and FTIR techniques with analytical methods available in our laboratory any drug wasn´t found. U1ZTV1 No drug was detected. U3LUJU UBB6JU Eucalyptol is present UHQQQQ No drug was detected by LC/MS/MS echnique UK1I4W no drugs found VHOLZ9

Code [blank sample] VNAAG2 Sample SM-4 was found not contain any drugs. VQI99W SAMPLE CONTAINS NO DRUG-BLANK SAMPLE VYHLIW W2WK2G Screening tests and Confirmation tests result Negative WWKYWV No substances, controlled or otherwise, were detected using the analytical methods on our GCMS. WWT4QM XGWDIY XJ7ZFQ XPESEF unknown plant matter without drug XVF202 A composite was formed from 1 unit for testing. No controlled substances identified in the composite. XXZXFD Y767IJ YJOK1X No controlled substance detected YQDKTM YRMRRY In sample 2017/2/SM-4 is not was found drugs YVZNNK No controlled substances we identified in this material. YX6UOI YZ1O11 YZYVX7 SM-4 is a blank sample Z3CTND The analysis did not reveal any controlled drug according to french order, decree of February 22nd 1990. ZM999M ZN3JO2 the vegetal material does not contain any of controlled sustances thar are incluided in our screening methods. ZZZLCZ

Identification methods for Test Sample 4

Legend: S ... used for Screening I ... used for Identification SI ... used for both

RESPONSE SUMMARY FOR TEST SAMPLE 4

Participants: 200

The response summary of all 200 participating laboratories for the identification of SM-4, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample:

Substance Name Number of laboratories: Blank 199

Identification of Test Sample-4:

Test sample 4 was a blank test sample prepared from damiana leaf

False positives for Test Sample-4:

Round Code: Substance reported: Tech Code: BVCWMH Tetrahydrocannabinol 161/180

False negatives for Test Sample-4 (techniques(s) used for ANP):

Round Code: Substance reported: Tech Code: BVCWMH Tetrahydrocannabinol 161/180

Frequency of use of screening, identification and quantification techniques:

The Laboratory and Scientific Section UNODC, International Centre Wagramer Strasse 5, P.O. Box 500 A-1400, Vienna, AUSTRIA Email: [email protected]