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PDF Output of CLIC (Clustering by Inferred Co-Expression) PDF Output of CLIC (clustering by inferred co-expression) Dataset: Num of genes in input gene set: 14 Total number of genes: 16493 CLIC PDF output has three sections: 1) Overview of Co-Expression Modules (CEMs) Heatmap shows pairwise correlations between all genes in the input query gene set. Red lines shows the partition of input genes into CEMs, ordered by CEM strength. Each row shows one gene, and the brightness of squares indicates its correlations with other genes. Gene symbols are shown at left side and on the top of the heatmap. 2) Details of each CEM and its expansion CEM+ Top panel shows the posterior selection probability (dataset weights) for top GEO series datasets. Bottom panel shows the CEM genes (blue rows) as well as expanded CEM+ genes (green rows). Each column is one GEO series dataset, sorted by their posterior probability of being selected. The brightness of squares indicates the gene's correlations with CEM genes in the corresponding dataset. CEM+ includes genes that co-express with CEM genes in high-weight datasets, measured by LLR score. 3) Details of each GEO series dataset and its expression profile: Top panel shows the detailed information (e.g. title, summary) for the GEO series dataset. Bottom panel shows the background distribution and the expression profile for CEM genes in this dataset. Overview of Co-Expression Modules (CEMs) with Dataset Weighting Scale of average Pearson correlations Num of Genes in Query Geneset: 14. Num of CEMs: 1. 0.0 0.2 0.4 0.6 0.8 1.0 Cpsf3l Polr2b Ints3 Ints7 Ints1 Ints4 Ints9 Ints2 Polr2a Ints5 Ints6 Ints12 Ints8 Ints10 Cpsf3l Polr2b Ints3 Ints7 Ints1 CEM 1 (130 datasets) Ints4 Ints9 Ints2 Polr2a Ints5 Ints6 Ints12 Singletons Ints8 Ints10 Symbol Num ofCEMGenes:9.Predicted1041.SelectedDatasets:130.Strength:1.5 CEM 1,Geneset"[C]Integrator-RNAPIIcomplex",Page1 Smarcc1 Smarca4 Tamm41 Nup214 Nup188 Nup107 Nup155 Nup133 Ruvbl1 Trim28 Polr2b Chtf18 Polr2a Ncbp1 Nup85 Cpsf3l Rfwd3 Lrwd1 Prmt5 Mcm6 Mcm5 Mcm7 Parp1 Cpsf1 Cpsf3 Xrcc6 Pold2 Noc2l Sf3b2 Sf3a3 Cse1l Msh6 Prpf8 Msh2 Sart3 Xpo5 Ints2 Ints9 Ints4 Ints1 Ints7 Ints3 Mlh1 Rfc1 Pole Eif3l Lig1 Gart Atic Ttf2 0.0 1.0 GSE33308 [10] GSE16679 [8] GSE26568 [6] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE44175 [18] GSE16925 [15] GSE32598 [11] GSE17886 [16] GSE27546 [51] GSE31849 [18] GSE6998 [32] GSE54207 [9] GSE26096 [10] GSE6689 [12] GSE27605 [8] GSE28593 [9] GSE13149 [25] GSE51483 [45] GSE28389 [20] GSE15155 [12] GSE17794 [44] GSE12454 [13] GSE15580 [14] GSE48790 [8] GSE8024 [8] GSE54490 [12] GSE5976 [12] GSE17796 [39] GSE13408 [14] GSE26355 [6] GSE30745 [12] GSE38531 [35] GSE47959 [8] GSE27159 [8] GSE54653 [6] GSE28261 [72] GSE43419 [20] GSE30868 [8] GSE11220 [44] GSE14308 [12] GSE21299 [12] GSE13874 [14] GSE30873 [6] GSE40513 [6] GSE31106 [18] GSE17266 [59] GSE20954 [14] GSE31028 [6] GSE29081 [6] GSE5671 [18] GSE47414 [18] GSE21278 [48] GSE6933 [15] GSE15610 [12] GSE15541 [12] GSE30160 [6] GSE31598 [12] GSE20391 [11] GSE17462 [8] GSE27378 [8] GSE12001 [6] GSE11222 [42] GSE39621 [51] GSE9013 [12] GSE28417 [12] GSE46209 [21] GSE11274 [20] GSE12465 [14] GSE15741 [6] GSE39458 [6] GSE11898 [9] GSE38031 [8] GSE26616 [6] GSE16707 [6] GSE1479 [36] GSE44923 [16] GSE15161 [26] GSE14012 [24] GSE48338 [8] GSE34324 [12] GSE56755 [13] GSE46970 [15] GSE15325 [23] GSE17728 [12] GSE16454 [24] GSE7404 [144] GSE32624 [6] GSE54581 [21] GSE54349 [6] GSE21063 [24] GSE1986 [17] GSE39391 [21] GSE24350 [8] GSE13707 [20] GSE21755 [25] GSE29241 [6] GSE23398 [7] GSE6065 [100] GSE19657 [21] GSE7275 [8] GSE42688 [8] GSE26668 [6] GSE46724 [6] GSE34629 [6] GSE32386 [13] GSE20398 [30] GSE46094 [10] GSE13692 [8] GSE46443 [12] GSE21033 [12] GSE51628 [15] GSE8091 [16] GSE28277 [10] GSE46797 [6] GSE2197 [6] GSE38001 [12] GSE56542 [8] GSE20390 [6] GSE12881 [6] GSE28025 [18] GSE11201 [18] GSE35998 [20] GSE40856 [8] GSE15872 [18] GSE14585 [9] GSE18326 [8] GSE47421 [24] GSE17513 [12] GSE29572 [21] GSE36384 [12] GSE15326 [10] GSE42061 [12] GSE18135 [18] GSE12518 [6] GSE42238 [9] GSE35091 [11] GSE7897 [60] GSE50813 [24] GSE4193 [8] GSE18993 [13] GSE42049 [8] GSE36814 [20] GSE9061 [6] GSE16874 [12] GSE31570 [6] GSE13224 [6] GSE58296 [9] GSE43197 [27] GSE11165 [6] GSE26076 [12] GSE42473 [15] GSE8025 [21] GSE41342 [26] GSE27261 [8] GSE45222 [27] CEM+ CEM GSE15268 [16] GSE8621 [12] GSE28093 [6] GSE3203 [16] GSE45619 [6] GSE32653 [6] 0.0 GSE51608 [6] GSE55607 [18] GSE12769 [20] Scale ofaveragePearsoncorrelations GSE20696 [8] GSE21711 [6] GSE6846 [6] GSE28621 [21] GSE22841 [12] GSE8683 [11] 0.2 GSE11356 [9] GSE25645 [17] GSE6957 [12] GSE17316 [12] GSE32330 [12] GSE47694 [10] GSE29766 [40] GSE10182 [7] GSE20918 [6] 0.4 GSE35357 [12] GSE44084 [8] GSE9316 [12] GSE13693 [9] GSE31099 [24] GSE9297 [27] GSE41925 [8] GSE11759 [6] GSE8034 [17] 0.6 GSE35785 [10] GSE31752 [6] GSE46090 [12] GSE47205 [10] GSE11333 [6] GSE50603 [12] GSE10871 [32] GSE23505 [10] GSE27563 [93] 0.8 GSE19885 [9] GSE45430 [9] GSE53299 [6] GSE9146 [27] Score 57.66 57.74 57.86 58.14 58.21 58.31 58.59 58.70 59.33 59.38 59.98 60.25 60.56 61.06 61.20 61.68 62.45 62.59 62.76 62.87 63.15 63.26 63.87 63.89 63.94 63.94 64.10 64.29 64.68 65.67 65.67 65.73 66.34 66.56 66.75 68.35 70.93 71.52 72.80 74.88 82.46 1.0 Notes Symbol Num ofCEMGenes:9.Predicted1041.SelectedDatasets:130.Strength:1.5 CEM 1,Geneset"[C]Integrator-RNAPIIcomplex",Page2 BC055324 Timeless Snrnp40 Ncapd2 Pdcd11 Skiv2l2 Ppp1r8 Ruvbl2 Rbm19 Ppm1g Wdhd1 Lmnb2 Heatr1 Prpf31 G3bp1 Dnmt1 Apitd1 Polr1a Dtymk Nup93 Nelfcd Eif2b5 Ddx20 Cdca5 Haus1 Actl6a Thoc5 Mcm4 Mcm2 Parp2 Pprc1 Cpsf4 Utp20 Xrcc1 Nat10 Bms1 Pold1 Espl1 Prpf3 Scrib Uba2 Rpa2 Rcc1 Ezh2 Fen1 Rfc5 Adsl Pfas Srrt Aqr 0.0 1.0 GSE33308 [10] GSE16679 [8] GSE26568 [6] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE44175 [18] GSE16925 [15] GSE32598 [11] GSE17886 [16] GSE27546 [51] GSE31849 [18] GSE6998 [32] GSE54207 [9] GSE26096 [10] GSE6689 [12] GSE27605 [8] GSE28593 [9] GSE13149 [25] GSE51483 [45] GSE28389 [20] GSE15155 [12] GSE17794 [44] GSE12454 [13] GSE15580 [14] GSE48790 [8] GSE8024 [8] GSE54490 [12] GSE5976 [12] GSE17796 [39] GSE13408 [14] GSE26355 [6] GSE30745 [12] GSE38531 [35] GSE47959 [8] GSE27159 [8] GSE54653 [6] GSE28261 [72] GSE43419 [20] GSE30868 [8] GSE11220 [44] GSE14308 [12] GSE21299 [12] GSE13874 [14] GSE30873 [6] GSE40513 [6] GSE31106 [18] GSE17266 [59] GSE20954 [14] GSE31028 [6] GSE29081 [6] GSE5671 [18] GSE47414 [18] GSE21278 [48] GSE6933 [15] GSE15610 [12] GSE15541 [12] GSE30160 [6] GSE31598 [12] GSE20391 [11] GSE17462 [8] GSE27378 [8] GSE12001 [6] GSE11222 [42] GSE39621 [51] GSE9013 [12] GSE28417 [12] GSE46209 [21] GSE11274 [20] GSE12465 [14] GSE15741 [6] GSE39458 [6] GSE11898 [9] GSE38031 [8] GSE26616 [6] GSE16707 [6] GSE1479 [36] GSE44923 [16] GSE15161 [26] GSE14012 [24] GSE48338 [8] GSE34324 [12] GSE56755 [13] GSE46970 [15] GSE15325 [23] GSE17728 [12] GSE16454 [24] GSE7404 [144] GSE32624 [6] GSE54581 [21] GSE54349 [6] GSE21063 [24] GSE1986 [17] GSE39391 [21] GSE24350 [8] GSE13707 [20] GSE21755 [25] GSE29241 [6] GSE23398 [7] GSE6065 [100] GSE19657 [21] GSE7275 [8] GSE42688 [8] GSE26668 [6] GSE46724 [6] GSE34629 [6] GSE32386 [13] GSE20398 [30] GSE46094 [10] GSE13692 [8] GSE46443 [12] GSE21033 [12] GSE51628 [15] GSE8091 [16] GSE28277 [10] GSE46797 [6] GSE2197 [6] GSE38001 [12] GSE56542 [8] GSE20390 [6] GSE12881 [6] GSE28025 [18] GSE11201 [18] GSE35998 [20] GSE40856 [8] GSE15872 [18] GSE14585 [9] GSE18326 [8] GSE47421 [24] GSE17513 [12] GSE29572 [21] GSE36384 [12] GSE15326 [10] GSE42061 [12] GSE18135 [18] GSE12518 [6] GSE42238 [9] GSE35091 [11] GSE7897 [60] GSE50813 [24] GSE4193 [8] GSE18993 [13] GSE42049 [8] GSE36814 [20] GSE9061 [6] GSE16874 [12] GSE31570 [6] GSE13224 [6] GSE58296 [9] GSE43197 [27] GSE11165 [6] GSE26076 [12] GSE42473 [15] GSE8025 [21] GSE41342 [26] GSE27261 [8] GSE45222 [27] CEM+ CEM GSE15268 [16] GSE8621 [12] GSE28093 [6] GSE3203 [16] GSE45619 [6] GSE32653 [6] 0.0 GSE51608 [6] GSE55607 [18] GSE12769 [20] Scale ofaveragePearsoncorrelations GSE20696 [8] GSE21711 [6] GSE6846 [6] GSE28621 [21] GSE22841 [12] GSE8683 [11] 0.2 GSE11356 [9] GSE25645 [17] GSE6957 [12] GSE17316 [12] GSE32330 [12] GSE47694 [10] GSE29766 [40] GSE10182 [7] GSE20918 [6] 0.4 GSE35357 [12] GSE44084 [8] GSE9316 [12] GSE13693 [9] GSE31099 [24] GSE9297 [27] GSE41925 [8] GSE11759 [6] GSE8034 [17] 0.6 GSE35785 [10] GSE31752 [6] GSE46090 [12] GSE47205 [10] GSE11333 [6] GSE50603 [12] GSE10871 [32] GSE23505 [10] GSE27563 [93] 0.8 GSE19885 [9] GSE45430 [9] GSE53299 [6] GSE9146 [27] Score 50.48 50.60 50.77 50.79 51.37 51.42 51.56 51.56 51.71 52.06 52.12 52.26 52.29 52.43 52.71 52.84 52.87 53.05 53.21 53.70 53.81 53.84 54.16 54.18 54.35 54.42 54.48 54.58 54.60 54.66 54.78 55.04 55.25 55.25 55.39 55.64 55.86 55.88 56.10 56.11 56.22 56.23 56.61 56.67 56.70 56.73 56.76 57.01 57.03 57.03 1.0 Notes Symbol Num ofCEMGenes:9.Predicted1041.SelectedDatasets:130.Strength:1.5 CEM 1,Geneset"[C]Integrator-RNAPIIcomplex",Page3 Mybbp1a Wbscr22 Tubgcp6 Mcm3ap Ctnnbl1 Mms22l Gemin5 Ranbp3 Zmym1 Cnot10 Incenp Bub1b Kpnb1 Wdr33 Ubap2 Rpap1 Ddx39 Dhx16 Ddx18 Rad51 Kif20a Dhx29 Cdca7 Prmt1 Rrp12 Prim2 Dars2 Gins1 Ssrp1 Chd1l Trmt6 Sf3b3 Pms2 Tcof1 Uhrf1 Gpn1 Wdr3 Eif3b Kif22 Rpa1 Cdc7 Aaas Hells Tdp1 Pes1 Melk Cdt1 Rfc2 Lyar Tbl3 0.0 1.0 GSE33308 [10] GSE16679 [8] GSE26568 [6] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE44175 [18] GSE16925 [15] GSE32598 [11] GSE17886 [16] GSE27546 [51] GSE31849 [18] GSE6998 [32] GSE54207 [9] GSE26096 [10] GSE6689 [12] GSE27605 [8] GSE28593 [9] GSE13149 [25] GSE51483 [45] GSE28389 [20] GSE15155 [12] GSE17794 [44] GSE12454 [13] GSE15580 [14]
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