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Product Datasheet MMP24 antibody orb138011

Description Rabbit polyclonal to MMP24. Matrix -24, also known as MT5MMP or MMP25, is an that in humans is encoded by the MMP24 . Proteins of the (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, Western blot analysis of the protein encoded by this gene is a member of the Lane membrane-type MMP (MT-MMP) subfamily; each member of this 1: PANC Cell Lysate, Lane subfamily contains a potential transmembrane domain 2: suggesting that these proteins are expressed at the cell surface HELA Cell Lysate, Lane 3: rather than secreted. This protein activates MMP2 by cleavage. SMMC The gene has previously been referred to as MMP25 but has been Cell Lysate, Lane 4: A549 renamed MMP24. This gene may be a proteoglycanase involved Cell in degradation of proteoglycans, such as dermatan sulfate and Lysate using MMP24 chondroitin sulfate proteoglycans. antibody

Species/Host Rabbit

Reactivity Human, Mouse, Rat

Conjugation Unconjugated

Tested Applications WB

Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human MMP24, identical to the related mouse and rat sequences.

Target MMP24

Form/Appearance Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Storage Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.

Note For research use only.

Reconstitution Add 0.2ml of distilled water will yield a concentration of 500 μg/ml.

Isotype IgG

Clonality Polyclonal

Purity Immunogen affinity purified.

Uniprot ID Q9Y5R2

Expiration Date 12 months from date of receipt.