Black Mamba’: an Overview of Brand
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Damiana/Turnera
Damiana/Turnera Introduction: Damiana is an excellent strengthening remedy for the nervous system. It has an ancient reputation as an aphrodisiac. Whilst this may or may not be true, it has a definite tonic action on the central nervous and the hormonal system. As a useful anti-depressant, Damiana is considered to be a specific in cases of anxiety and depression where there is a sexual factor. It may be used to strengthen the male sexual system. Scientific name: Turnera diffusa Var. aphrodisiaca Synonyms:Turnera aphrodisiaca; Turnera microphylla. Sources: The main source of Damiana is vegetable source. It is a shrub native to southern Texas in the United States, Central America, Mexico, South America, and the Caribbean. It belongs to the family Passifloraceae (Turneraceae). Damiana contains damianin; tetraphyllin B; gonzalitosin I; arbutin; tricosan-2-one; acacetin; p-cymene; β-sitosterol; 1,8-cineole; apigenin; α-pinene; β-carotene; β-pinene; tannins; thymol; and hexacosanol. In total, 22 flavonoids, maltol glucoside, phenolics, seven cyanogenic glycosides, monoterpenoids, sesquiterpenoids, triterpenoids, the polyterpene ficaprenol-11, fatty acids, and caffeine have been found in the genus Turnera. Damiana's anxiolytic properties might be due to apigenin. Viable plant and seed material sold as T. diffusa from both private and commercial sources largely turns out to be misidentified Turnera ulmifolia (a.k.a. "False Damiana"), a closely related species. This widespread issue has been noted by the scientific community, and has created much confusion among both amateur and professional horticulturists alike. While T. ulmifolia is similar in appearance, its chemical constituents and ethnobotanical uses are distinctly different. -
(12) Patent Application Publication (10) Pub. No.: US 2016/017.4603 A1 Abayarathna Et Al
US 2016O174603A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/017.4603 A1 Abayarathna et al. (43) Pub. Date: Jun. 23, 2016 (54) ELECTRONIC VAPORLIQUID (52) U.S. Cl. COMPOSITION AND METHOD OF USE CPC ................. A24B 15/16 (2013.01); A24B 15/18 (2013.01); A24F 47/002 (2013.01) (71) Applicants: Sahan Abayarathna, Missouri City, TX 57 ABSTRACT (US); Michael Jaehne, Missouri CIty, An(57) e-liquid for use in electronic cigarettes which utilizes- a TX (US) vaporizing base (either propylene glycol, vegetable glycerin, (72) Inventors: Sahan Abayarathna, MissOU1 City,- 0 TX generallyor mixture at of a 0.001 the two) g-2.0 mixed g per with 1 mL an ratio. herbal The powder herbal extract TX(US); (US) Michael Jaehne, Missouri CIty, can be any of the following:- - - Kanna (Sceletium tortuosum), Blue lotus (Nymphaea caerulea), Salvia (Salvia divinorum), Salvia eivinorm, Kratom (Mitragyna speciosa), Celandine (21) Appl. No.: 14/581,179 poppy (Stylophorum diphyllum), Mugwort (Artemisia), Coltsfoot leaf (Tussilago farfara), California poppy (Eschscholzia Californica), Sinicuichi (Heimia Salicifolia), (22) Filed: Dec. 23, 2014 St. John's Wort (Hypericum perforatum), Yerba lenna yesca A rtemisia scoparia), CaleaCal Zacatechichihichi (Calea(Cal termifolia), Leonurus Sibericus (Leonurus Sibiricus), Wild dagga (Leono Publication Classification tis leonurus), Klip dagga (Leonotis nepetifolia), Damiana (Turnera diffiisa), Kava (Piper methysticum), Scotch broom (51) Int. Cl. tops (Cytisus scoparius), Valarien (Valeriana officinalis), A24B 15/16 (2006.01) Indian warrior (Pedicularis densiflora), Wild lettuce (Lactuca A24F 47/00 (2006.01) virosa), Skullcap (Scutellaria lateriflora), Red Clover (Trifo A24B I5/8 (2006.01) lium pretense), and/or combinations therein. -
US EPA, Pesticide Product Label, A335.06,09/21/2020
[Note to reviewer: [Text] in brackets denotes optional or explanatory language [Note to reviewer: {Text} in braces denotes where in the final label text will appear {BOOKLET FRONT PANEL LANGUAGE} S-METOLACHLOR GROUP 15 HERBICIDE METRIBUZIN GROUP 5 HERBICIDE FOMESAFEN GROUP 14 HERBICIDE A335.06[™] [Alternate Brand Name: Statler] [Herbicide for preemergent control of certain grasses and broadleaf weeds in Soybeans] ACTIVE INGREDIENTS: (% by weight) S-Metolachlor*………………………………………….……………………………………………………………………………..…………………… 36.29% Metribuzin**………………………………………….……………………………………………………………………………..………………………. 8.05% Fomesafen***………………………………………….……………………………………………………………………………..……………………... 7.16% OTHER INGREDIENTS: ……………………………………………………..…………………………………………………………………………….. 48.5% TOTAL …………………………………………………………………………………………………………….……………………………………………. 100.0% *contains 3.39 Ib of S-metolachlor per gallon **contains 0.75 Ib of metribuzin per gallon ***contains 0.67 Ib of fomesafen acid per gallon KEEP OUT OF REACH OF CHILDREN CAUTION Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. (If you do not understand the label, find someone to explain it to you in detail.) See [below] [inside label booklet] for [additional] [First Aid,] [Precautionary Statements] and [Directions for Use]. EPA Reg. No.: 91234-201 EPA Est. No.: Net Weight: Manufactured for: Atticus, LLC 5000 CentreGreen Way, Suite 100 Cary, NC 27513 1 {LANGUAGE INSIDE BOOKLET} FIRST AID If on skin or Take off contaminated clothing. clothing: Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice. If swallowed: Call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor. -
Acetylcholinesterase — New Roles for Gate a Relatively Long Distance to Reach the Active Site, Ache Is One of the Fastest an Old Actor Enzymes14
PERSPECTIVES be answered regarding AChE catalysis; for OPINION example, the mechanism behind the extremely fast turnover rate of the enzyme. Despite the fact that the substrate has to navi- Acetylcholinesterase — new roles for gate a relatively long distance to reach the active site, AChE is one of the fastest an old actor enzymes14. One theory to explain this phe- nomenon has to do with the unusually strong electric field of AChE. It has been argued that Hermona Soreq and Shlomo Seidman this field assists catalysis by attracting the cationic substrate and expelling the anionic The discovery of the first neurotransmitter — understanding of AChE functions beyond the acetate product15. Site-directed mutagenesis, acetylcholine — was soon followed by the classical view and suggest the molecular basis however, has indicated that reducing the elec- discovery of its hydrolysing enzyme, for its functional heterogeneity. tric field has no effect on catalysis16.However, acetylcholinesterase. The role of the same approach has indicated an effect on acetylcholinesterase in terminating From early to recent discoveries the rate of association of fasciculin, a peptide acetylcholine-mediated neurotransmission The unique biochemical properties and phys- that can inhibit AChE17. made it the focus of intense research for iological significance of AChE make it an much of the past century. But the complexity interesting target for detailed structure–func- of acetylcholinesterase gene regulation and tion analysis. AChE-coding sequences have recent evidence for some of the long- been cloned so far from a range of evolution- a Peripheral Choline binding site suspected ‘non-classical’ actions of this arily diverse vertebrate and invertebrate binding enzyme have more recently driven a species that include insects, nematodes, fish, site profound revolution in acetylcholinesterase reptiles, birds and several mammals, among Active site research. -
Green Mamba Peptide Targets Type-2 Vasopressin Receptor Against Polycystic Kidney Disease
Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease Justyna Cioleka,1, Helen Reinfrankb,1,2, Lo¨ıc Quintonc, Say Viengchareund, Enrico A. Sturaa, Laura Veraa,3, Sabrina Sigismeaua, Bernard Mouillace,Hel´ ene` Orcele, Steve Peigneurf, Jan Tytgatf, Laura Droctove´ a, Fabrice Beaua, Jerome Nevouxd, Marc Lombes` d, Gilles Mouriera, Edwin De Pauwc, Denis Serventa, Christiane Mendree,4, Ralph Witzgallb,4, and Nicolas Gillesa,4 aService d’Ingenierie´ Moleculaire´ des Proteines,´ Institut des Sciences du Vivant Fred´ eric´ Joliot, Commissariat a` l’Energie Atomique, Universite´ Paris-Saclay, F-91191 Gif sur Yvette, France; bInstitute for Molecular and Cellular Anatomy, University of Regensburg, 93053 Regensburg, Germany; cLaboratoire de Spectrometrie´ de Masse, Unite´ de Recherche Molecular Systems, Universite´ de Liege,` Liege` 4000, Belgium; dINSERM U1185, Universite´ Paris Sud, Universite´ Paris-Saclay, F-94276, Le Kremlin-Bicetre,ˆ France; eInstitut de Genomique´ Fonctionnelle, CNRS, INSERM, Universite´ Montpellier, F-34094 Montpellier, France; and fLaboratory of Toxicology, University of Leuven, Leuven B-3000, Belgium Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved April 13, 2017 (received for review December 17, 2016) Polycystic kidney diseases (PKDs) are genetic disorders that can therapeutic approach, the use of V2R antagonists has certain cause renal failure and death in children and adults. Lowering advantages (7, 8). Most renal ADPKD cysts develop within the cAMP in cystic tissues through the inhibition of the type-2 vaso- vasopressin-sensitive tubular parts of the nephron, where vaso- pressin receptor (V2R) constitutes a validated strategy to reduce pressin is also the main hormonal regulator of adenylyl cyclase disease progression. -
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Hallucinogens And Dissociative Drug Use And Addiction Introduction Hallucinogens are a diverse group of drugs that cause alterations in perception, thought, or mood. This heterogeneous group has compounds with different chemical structures, different mechanisms of action, and different adverse effects. Despite their description, most hallucinogens do not consistently cause hallucinations. The drugs are more likely to cause changes in mood or in thought than actual hallucinations. Hallucinogenic substances that form naturally have been used worldwide for millennia to induce altered states for religious or spiritual purposes. While these practices still exist, the more common use of hallucinogens today involves the recreational use of synthetic hallucinogens. Hallucinogen And Dissociative Drug Toxicity Hallucinogens comprise a collection of compounds that are used to induce hallucinations or alterations of consciousness. Hallucinogens are drugs that cause alteration of visual, auditory, or tactile perceptions; they are also referred to as a class of drugs that cause alteration of thought and emotion. Hallucinogens disrupt a person’s ability to think and communicate effectively. Hallucinations are defined as false sensations that have no basis in reality: The sensory experience is not actually there. The term “hallucinogen” is slightly misleading because hallucinogens do not consistently cause hallucinations. 1 ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com How hallucinogens cause alterations in a person’s sensory experience is not entirely understood. Hallucinogens work, at least in part, by disrupting communication between neurotransmitter systems throughout the body including those that regulate sleep, hunger, sexual behavior and muscle control. Patients under the influence of hallucinogens may show a wide range of unusual and often sudden, volatile behaviors with the potential to rapidly fluctuate from a relaxed, euphoric state to one of extreme agitation and aggression. -
Snap-On Industrial April 23, 1014 Page 1 Item Number Description
Snap-on Industrial April 23, 1014 Unit of Item Number Description Net Price Measure 00000072E00 TURNTABLE VTA 1 SET 2 PC 550.27 Each 00000096000 DEPRESSOR ASSY-PEDAL 35.37 Each 00000129000 ALIGNMENT WHEEL STANDS 1309.19 Each 00001260000 TURNTABLE TRUCK 1 SET OF 2 1210.66 Each 00006310000 CONE-ADAPT. SET CAN USE 110612 300.54 Each 00043102Q00 ECONO 4-POST 172 7904.23 Each 00044218Q00 4 POST CLOSED CENTER 18K LIFT 22045.54 Each 00055502000 CLAMP ASSY-WHEEL,STEER 62.31 Each 00058839000 TOOL-PDQ WEIGHT PASS CAR 34.5 Each 00060466000 DUAL WHEEL SPACER 160.5 Each 00060779000 CONE-MEDIUM 9 1/2 DEG 82.1 Each 00060873000 CONE-TRUCK GRIND 241.29 Each 00060874000 SPACER-WHEEL TRUCK 173.82 Each 00064222000 REAR SLIPPLATES 483.82 Each 00066006000 LUBE BOTTLE 24.18 Each 00090488000 TRI TIPS/SETS SCREWS- 10 44.06 Each 00110560000 CONE-CENTERING 75-110MM HAWE 79.55 Each 00110612000 TRUCK CONE KIT 261.4 Each 00110614000 ADAPTER-UNILUG SEE REMARKS 538.16 Each 00112094000 OPTIONAL HVY DTY KIT 3.5 1456.61 Each 00112109000 DAYTON WHEEL ADAPTER 24 1033 Each 00112111000 4 ARM STAR QK ADPTR 702958178 889.5 Each 00112112000 5 ARM STAR QK ADPTR 702958179 942 Each 00112113000 4 TO 5 STAR UPDATE KT70295818 412.5 Each 00112292000 220.1MM HWKA 70BE958-008 321.54 Each 00112320000 DISC-220.8MM 70BE 958 007 448.33 Each 10002MRMHCDI TORQUE WRENCH 150-1000INLB 110.36 Each 10-01085A LOCK-N-ROLL LATCH 67 IN. 3.09 Each 10-01185A LOCK N ROLL LATCH FOR KRL1099 1.83 Each 1001XL36PV SLDG TRAY 21.45 Each 10-03783A TR DR SLVR EPLS 27.99 KRSC30 2.02 Each 10059 BEARING NEEDLE THRUST -
Ion Channels
UC Davis UC Davis Previously Published Works Title THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels. Permalink https://escholarship.org/uc/item/1442g5hg Journal British journal of pharmacology, 176 Suppl 1(S1) ISSN 0007-1188 Authors Alexander, Stephen PH Mathie, Alistair Peters, John A et al. Publication Date 2019-12-01 DOI 10.1111/bph.14749 License https://creativecommons.org/licenses/by/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California S.P.H. Alexander et al. The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. British Journal of Pharmacology (2019) 176, S142–S228 THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels Stephen PH Alexander1 , Alistair Mathie2 ,JohnAPeters3 , Emma L Veale2 , Jörg Striessnig4 , Eamonn Kelly5, Jane F Armstrong6 , Elena Faccenda6 ,SimonDHarding6 ,AdamJPawson6 , Joanna L Sharman6 , Christopher Southan6 , Jamie A Davies6 and CGTP Collaborators 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK 2Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue, Chatham Maritime, Chatham, Kent, ME4 4TB, UK 3Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK 4Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria 5School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK 6Centre for Discovery Brain Science, University of Edinburgh, Edinburgh, EH8 9XD, UK Abstract The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. -
Turnera Diffusa ‘Luisa’, Mm Wide
HORTSCIENCE 45(12):1895–1896. 2010. late bracteoles, 4.0 to 5.0 mm long and 1.0 mm wide. The flowers are actinomorphic and rotate, each lasting 1 d, and 12.53 ± 1.11 Turnera diffusa ‘Luisa’, mm wide. The calyx is 6.0 to 7.0 mm long and 2.0 to 3.0 mm wide, consisting of five a Drought-tolerant Small Shrub sepals fused in the lower two-thirds, the free portions lanceolate and acute at the apex, and for Warm Climates RHS yellow–green 154D (L* = 84.66 ± 2.58, a* = –4.20 ± 0.38, b* = 24.18 ± 6.27). The Alan W. Meerow1 and Toma´s Ayala-Silva corolla consists of five petals fused below USDA-ARS-SHRS, National Germplasm Repository, 13601 Old Cutler Road, into a short tube, 1.5 to 2.0 mm wide, and Miami, FL 33158 RHS yellow–orange 14A (L* = 72.47 ± 1.06, a* = 3.59 ± 1.33, b* = 59.33 ± 5.23); each Brian M. Irish petal is 5.60 ± 0.43 mm long and 4.12 ± 0.15 USDA-ARS-TARS, National Germplasm Repository, 2200 Pedro Albizu-Campos mm wide and cleft at the apex. The five filiform stamens are 5.0 to 5.4 mm long and Avenue, Suite 201, Mayaguez, Puerto Rico, 00680 the versatile anthers 0.7 to 1.0 mm long and Additional index words. Turneraceae, Puerto Rico, tropical shrubs, ornamentals, landscape yellow. There are three styles, 1.3 to 1.5 mm long, each three- to four-branched in the apical half. -
M4 Muscarinic Receptors Are Involved in Modulation of Neurotransmission at Synapses of Schaffer Collaterals on CA1 Hippocampal Neurons in Rats
Journal of Neuroscience Research 87:691–700 (2009) M4 Muscarinic Receptors Are Involved in Modulation of Neurotransmission at Synapses of Schaffer Collaterals on CA1 Hippocampal Neurons in Rats Gonzalo Sa´nchez,1 Lucas de Oliveira Alvares,2,3 Marı´a Victoria Oberholzer,1 Bruna Genro,2 Jorge Quillfeldt,2 Jaderson Costa da Costa,3 Carlos Cerven˜ansky,4 Diana Jerusalinsky,1 and Edgar Kornisiuk1* 1Laboratorio de Neuroplasticidad y Neurotoxinas, Instituto de Biologı´a Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires y CONICET, Buenos Aires, Argentina 2Laborato´rio de Psicobiologia e Neurocomputac¸a˜o, Dep. de Biofisica, Instituto de Biocieˆncias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil 3Laborato´rio de Neurocieˆncias, Instituto de Pesquisas Biome´dicas, Pontificia Universidade Cato´lica do Rio Grande do Sul, Porto Alegre, Brazil 4Instituto Pasteur de Montevideo e IIBCE, Montevideo, Uruguay All five subtypes of muscarinic acetylcholine receptors Key words: muscarinic acetylcholine receptor; CA1 (mAChR; M1–M5) are expressed in the hippocampus, synapses; long-term potentiation; rat hippocampus; where they are involved both in cognitive functions and muscarinic toxin 3 in synaptic plasticity, such as long-term potentiation (LTP). Muscarinic toxins (MTs) are small proteins from All five subtypes of muscarinic acetylcholine recep- mamba snake venoms that display exquisite discrimi- tors (mAChR; M1–M5; Bonner et al., 1987) are nation between mAChRs. MT1 acts as an agonist at expressed in the hippocampus -
Woody and Herbaceous Plants Native to Haiti for Use in Miami-Dade Landscapes1
Woody and Herbaceous Plants Native to Haiti For use in Miami-Dade Landscapes1 Haiti occupies the western one third of the island of Hispaniola with the Dominican Republic the remainder. Of all the islands within the Caribbean basin Hispaniola possesses the most varied flora after that of Cuba. The plants contained in this review have been recorded as native to Haiti, though some may now have been extirpated due in large part to severe deforestation. Less than 1.5% of the country’s original tree-cover remains. Haiti’s future is critically tied to re- forestation; loss of tree cover has been so profound that exotic fast growing trees, rather than native species, are being used to halt soil erosion and lessen the risk of mudslides. For more information concerning Haiti’s ecological plight consult references at the end of this document. For present purposes all of the trees listed below are native to Haiti, which is why non-natives such as mango (the most widely planted tree) and other important trees such as citrus, kassod tree (Senna siamea) and lead tree (Leucanea leucocephala) are not included. The latter two trees are among the fast growing species used for re-forestation. The Smithsonian National Museum of Natural History’s Flora of the West Indies was an invaluable tool in assessing the range of plants native to Haiti. Not surprisingly many of the listed trees and shrubs 1 John McLaughlin Ph.D. U.F./Miami-Dade County Extension Office, Homestead, FL 33030 Page | 1 are found in other parts of the Caribbean with some also native to South Florida. -
Antivenin Plants Used for Treatment of Snakebites in Uganda
Omara et al. Tropical Medicine and Health (2020) 48:6 Tropical Medicine https://doi.org/10.1186/s41182-019-0187-0 and Health REVIEW Open Access Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences Timothy Omara1,2* , Sarah Kagoya3,4, Abraham Openy5, Tom Omute6, Stephen Ssebulime7, Kibet Mohamed Kiplagat8 and Ocident Bongomin9 Abstract Snakebite envenomation is a serious public health concern in rural areas of Uganda. Snakebites are poorly documented in Uganda because most occur in rural settings where traditional therapists end up being the first-line defense for treatment. Ethnobotanical surveys in Uganda have reported that some plants are used to antagonize the activity of various snake venoms. This review was sought to identify antivenin plants in Uganda and some pharmacological evidence supporting their use. A literature survey done in multidisciplinary databases revealed that 77 plant species belonging to 65 genera and 42 families are used for the treatment of snakebites in Uganda. The majority of these species belong to family Fabaceae (31%), Euphorbiaceae (14%), Asteraceae (12%), Amaryllidaceae (10%) and Solanaceae (10%). The main growth habit of the species is shrubs (41%), trees (33%) and herbs (18%). Antivenin extracts are usually prepared from roots (54%) and leaves (23%) through decoctions, infusions, powders, and juices, and are administered orally (67%) or applied topically (17%). The most frequently encountered species were Allium cepa, Carica papaya, Securidaca longipedunculata, Harrisonia abyssinica, and Nicotiana tabacum. Species with global reports of tested antivenom activity included Allium cepa, Allium sativum, Basella alba, Capparis tomentosa, Carica papaya, Cassia occidentalis, Jatropa carcus, Vernonia cinereal, Bidens pilosa, Hoslundia opposita, Maytensus senegalensis, Securinega virosa, and Solanum incanum.