Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 5 July 2020 doi:10.20944/preprints202007.0046.v1 Article Targeted High Volume Hemofiltration Could Avoid Extracorporeal Membrane Oxygenation in Some Patients with Severe Hantavirus Cardiopulmonary Syndrome René López1, 2, Rodrigo Pérez-Araos1, 3, Álvaro Salazar1, Mauricio Espinoza1, 2, Cecilia Vial4, Analia Cuiza 4, Pablo A. Vial2, 4, 5, and Jerónimo Graf1, 2* 1. Departamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago 7650567, Chile;
[email protected] (R.L.);
[email protected] (R.P-A.);
[email protected] (Á .S.);
[email protected] (M.E);
[email protected] (J.G.) 2. Escuela de Medicina. Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago 7710162, Chile;
[email protected] (P.A.V.) 3. Escuela de Kinesiología. Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago 7710162, Chile 4. Programa Hantavirus, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7590943, Chile;
[email protected] (C.V.);
[email protected] (A.C.) 5. Departamento de Pediatría, Clínica Alemana de Santiago, Santiago 7650567, Chile Correspondence:
[email protected] Abstract Background: Hantavirus cardiopulmonary syndrome (HCPS) has a high lethality. About two-thirds of the severe cases may be rescued by extracorporeal membrane oxygenation (ECMO). However, about half of the patients supported by ECMO suffer major complications. High volume hemofiltration (HVHF) is a depurative extracorporeal support that provides homeostatic balance allowing hemodynamic stabilization in some critically ill patients. Methods: We implemented HVHF prior to ECMO consideration in the last five severe HCPS patients requiring mechanical ventilation and vasoactive drugs admitted to our intensive care unit.