The Activity of 2,3-Dimethylquinoxaline Against Madurella Mycetomatis
American Journal of www.biomedgrid.com Biomedical Science & Research ISSN: 2642-1747 --------------------------------------------------------------------------------------------------------------------------------- Research Article Copy Right@ Abdelbagi Alfadil The Activity of 2,3-Dimethylquinoxaline against Madurella mycetomatis Abdelbagi Alfadil1*, Ahmed Shaker Ali2, Hamoud Alsamhan2,3, Huda Alkreathy2, Asif Jiman-Fa- tani1 and Hind Abdulmajed1 1Department of Microbiology and Medical Parasitology, King Abdulaziz University, Saudi Arabia 2Department of Pharmacology, King Abdulaziz University, Saudi Arabia 3College of Pharmacy, King Saud bin Abdulaziz University for Health Science, Saudi Arabia *Corresponding author: Abdelbagi Alfadil Mousa, Department of Microbiology and Medical Parasitology, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. To Cite This Article: Abdelbagi A, A Shaker Ali, H Alsamhan, H Alkreathy, A Jiman-Fatani. H Abdulmajed. The Activity of 2,3-Dimethylquinox- aline against Madurella mycetomatis. Am J Biomed Sci & Res. 2021 - 11(4). AJBSR.MS.ID.001654. DOI: 10.34297/AJBSR.2021.11.001654. Received: January 06, 2021; Published: January 18, 2021 Abstract Objective: Madurella mycetomatis is the most prevalent causative species of the eumycetoma, a chronic progressive neglected tropical disabling treatment is challenging, requires prolonged therapy, resulting in low cure rates and a high incidence of recurrence. Screening new compounds for antifungalinfectious diseaseactivity ofagainst the subcutaneous Madurella mycetomatis tissue. It carries is needed. a significant social and economic burden to the endemic areas. Unfortunately, the available Design: In vitro: the susceptibility of a Madurella mycetomatis of 2,3-dimethylquinoxaline 1% topical gel against the same strain was evaluated in the BALB/c mouse eumycetoma model (n=6; 6-8 weeks old). isolate toward the 2,3-dimethylquinoxaline was determined. In vivo: the efficacy Results: 2,3-Dimethylquinoxaline inhibited the growth of Madurella mycetomatis at MIC 312 µg/ml (1.9 mM).
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