Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Catalog Number : T5940 CAS Number : 603-00-9 Molecular Formula : C10H14N4O3 Molecular Weight : 238.24

Description: Proxyphylline is a dual of A1/A2a inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac , vasodilator and .

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

DMSO 47 mg/mL (197.28 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Receptor (IC50) adenosine A1/A2a receptor;PDE

In vitro Activity Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline[1]

Reference 1. Kukovetz W R , G P ch, Holzmann S . Overadditive synergism between , and proxyphylline in tracheal smooth muscle relaxation[J]. Arzneimittel-Forschung, 1983, 33(10):1450-1454. 2. Takeda K , Katano Y , Nakagawa Y , et al. EFFECTS OF AMINOPHYLLINE, PROXYPHYLLINE AND A PROXYPHYLLINE- MELILOTUS EXTRACT-RUTIN MIXTURE (THEOESBERIVEN) ON THE HEART AND THE CORONARY CIRCULATION[J]. The Japanese Journal of Pharmacology, 1977, 27(5):709-720. 3. Rasmussen F V , Waldorff S , Madsen L . and bronchodilatory effect of proxyphylline and theophylline.[J]. Eur J Respir Dis, 1984, 65(1):20-27.

FOR RESEARCH PURPOSES ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE. Information for product storage and handling is indicated on the product datasheet. Targetmol products are stable for long term under the recommended storage conditions. Our products may be shipped under different conditions as many of them are stable in the short-term at higher or even room temperatures. We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, please follow the storage recommendations on the product data sheet.

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