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Home , Arthur Kornberg, Howard Martin Temin, List of geneticists

Name: ______1 2

Now its time to forget about and to start learning about history. Just Kidding!!!! We’re going to learn more about both biology and history. This web quest/scavenger hunt is designed to help you understand how our knowledge of heredity and DNA has developed over the years. You must complete this assignment by the end of the period. Good Luck!!

 Go to http://www.dnai.org  Click on timeline.  Here you will see columns labeled with different decades. In the column is a list of important scientists and their discoveries.  Click on a column and it takes you to a more detailed description.  There is a picture of each scientist. Roll over the picture to find out who it is. Click on the picture to read the bio. Roll over the cartoon to find out what the experiment was and click that picture to watch an animated description of the experiment(s).  Above the scientists is a timeline of other important events occurring in the world.  Below are links to other decades.

Answer the following Questions  If it says “Jeopardy!!”, remember, your answers must be in the form of a question.

Pre 1920’s 1. So we’ve been talking a lot about Mendel and his pea plants, yada yada yada. Click on his experiment and list three reasons why pea plants are good to do research on. a. b. c. 2. When was Mendel’s research finally understood? ______(HINT: read Mendel’s bio or read about the experiments of Correns, Vries, and Tschermak-Seyseneg) BONUS: What did Miescher believe was really the of heredity? (HINT: read his bio) ______3. Mendel discovered the basis of inheritance in that traits are passed on in specific ways. This guy: ______discovered the chromosomal theory of inheritance. 4. So, Mendel was way ahead of his time? Circle YES or NO If yes then why.

(in case you were wondering, the answer is yes) 5. Who was working on his experiments when the Titanic sank? ______Bonus: Who said this: “You’re here, there’s nothing I fear, and I know that my heart will go on.” ______6. When Thomas Morgan was researching fruit flies, he noticed the presence of a white eyed mutant. This led to the discovery of ______linked traits. Briefly explain what you think is meant by sex-linked traits.

Jeopardy!!!! (your answers must be in the form of a question) 7. It took him eight years and more than 10,000 pea plants to discover the laws of inheritance.

8. I first isolated DNA using pus collected from bandages at a local hospital. Since white blood cells are a major component of pus, they were my source of DNA. Yuck!

9. The “fly room” at was established through my efforts. Imagine working in a room filled with bottle after bottle of fruit flies!

10. Miescher named it nuclein.

1920’s- 1949 10. Herman Mueller discovered that X-rays do what to DNA? ______(Ever wonder why they make you wear a lead apron at the dentist) 12. What was Barbara McClintock famous for discovering? ______What in the world is that? Explain.

BONUS: Briefly explain the one gene one theory. (Beadle and Tatum)

20. Why was it that died from cancer at such an early age? (hint: think Herman Mueller)

Jeopardy!!! 15. Next time you’re munching away at the movies, think of this Nobel-Prize winning scientist who figured out the process of transposition in corn .

17. He discovered the harmful effects of x-rays and discouraged excessive use in Medicine.

18. In ’s DNA model, which direction were the bases facing?

19. These are the two most famous dudes on this timeline.

21. She was given the nicknames “Rosie” and “The Dark Lady of DNA”

22. He came up with a triple stranded helical model of DNA.

Late 1950’s

24. Read about ’s experiments. Tell me what “The Central Dogma” means. (P.S. If you learn only one thing from all of our and DNA talk, then it should be this)

BONUS: There are exceptions to this rule, however, they were not discovered until later on. What would one exception be? (hint: 1970’s and )

25. What is the enzyme that synthesizes DNA. ______(Hint: ) 26. When did Disneyland open? ______

The 1970’s Did you know that up to 6 feet of DNA is packaged to fit into the nucleus of a single .?

27. Read the beginning of Roger Kornberg’s experiments. What class of is involved in structure? ______28. was the first person to ______?

1990’s and beyond

29. Read Mary Clair King’s bio. She was researching an inherited form of what disease? ______30. Read the first paragraph of ’s bio. He was in the race to do what? ______31. When was the human project completed? ______(look at the timeline?) 32. , the director of the National Research Institute (one of the groups involved in the ) grew up where? ______

Final questions:

What did you think about this activity and this website?

I learned about some important scientists involved in genetics and DNA research. Agree Disagree I thought the information was too complicated to understand. Agree Disagree I thought this was a pretty cool website even though there was a lot to read. Agree Disagree I think it’s amazing that because of science we know so much about DNA, our bodies, and diseases. Agree Disagree

I didn’t finish this activity because…

If you finish early, go to the dnai.org main page and click on Genome. Read the information that is in the link and write a quick 5 sentence summary of the Human Genome Project.