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Synthetic Biology and the CBD Five Key Decisions for COP 13 & COP-MOP 8

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Synthetic Biology and the CBD Five Key Decisions for COP 13 & COP-MOP 8 Synthetic Biology and the CBD Five key decisions for COP 13 & COP-MOP 8 Synthetic biology threatens to undermine all What Is Synthetic Biology? three objectives of the Convention if Parties fail to act on the following 5 key issues: Synthetic biology describes the next generation of biotechnologies that attempt to engineer, re- 1. Operational Definition. It’s time for the design, re-edit and synthesize biological systems, CBD to adopt an operational definition of including at the genetic level. synthetic biology. Synthetic biology goes far beyond the first 2. Precaution: Gene drives. Gene drives pose generation of ‘transgenic’ engineered organisms. wide ecological and societal threats and should Predicted to be almost a 40 billion dollar (US) be placed under a moratorium. market by 2020, industrial activity in synthetic 3. Biopiracy: Digital Sequences. Synthetic biology is rapidly exploding as new genome biology allows for digital theft and use of DNA editing tools and cheaper synthesis of DNA sequences – this must be addressed by both the make it easier and faster to genetically re-design CBD and the Nagoya Protocol. or alter biological organisms. Synthetic biology-derived products already on 4. Socio-economic Impacts: Sustainable Use. the market include biosynthesized versions of The CBD needs a process to address impacts flavors, fragrances, fuels, pharmaceuticals, of synthetic biology on sustainable use of textiles, industrial chemicals, cosmetic and food biodiversity. ingredients. A next generation of synthetically 5. Cartagena Protocol: Risk Assessment. engineered (including ‘genome edited’) crops, Parties to the COP-MOP 8 need to clearly insects and animals are also nearing move forward with elaborating risk assessment commercialization. This includes far-reaching guidance on synthetic biology. proposals to release gene drives – self-replicating genetic elements that aim to re-engineer or eradicate entire species at a time. This brief has been prepared by The International Civil Society Working Group On Synthetic Biology. Members include: Ecoropa, EcoNexus, ETC Group, Friends of the Earth, GeneEthics, Heinrich Boell Foundation and Third World Network. Synthetic Biology at the CBD What is at Stake at COP 13? – the story so far For almost a quarter century, the Convention on Biological Diversity and its protocols have been the Synthetic biology has been under discussion at the premier international body exercising oversight and Convention on Biological Diversity (CBD) for six carrying out international deliberation on how years. The CBD is the only international body developments in biotechnology affect the living world. addressing governance of this rapidly growing field. The programme of work on synthetic biology at the At COP 12, a landmark decision on synthetic CBD represents the only comprehensive international biology (Dec XII/24) emphasized the need for process currently underway to attempt to assess the risks precaution, regulatory systems and socio-economic from these potentially disruptive new developments and risk assessment. An online forum and AHTEG which may impact all 3 objectives of the Convention. (Ad Hoc Technical Expert Group) was established As new techniques such as CRISPR gene editing, DNA to address seven questions posed by the COP and to synthesis and far-reaching applications such as gene provide an operational definition to allow further drives radically transform the power and scope of work. SBSTTA 16 then provided advice for COP. biotechnology to impact biodiversity, it is urgent that Meanwhile the AHTEG on Risk Assessment of international governance arrangements are kept updated Living Modified Organisms established under the and made relevant. Cartagena Protocol was also tasked to discuss this Worryingly, the biotechnology industry appears to be topic. The AHTEG on Risk Assessment has deliberately attempting to frame the new technologies as developed an outline of guidance on “Risk exempt from existing rules and definitions. This would Assessment of LMOs developed through synthetic leave this next generation of biotechnology less assessed biology”, and the issue will be discussed at and less regulated than its predecessor. Unless Parties to COPMOP8 of the Cartagena Protocol. Parties to the CBD can agree an operational definition for the Protocol are asked to consider establishing a synthetic biology and commit to a forward-going plan of process for the development of guidance on the work addressing at least the most urgent implications, basis of the outline developed, in coordination with the world risks hurtling blind into a very uncertain and relevant processes under the CBD. risky future without an appropriate set of governance Following the outcome of those processes, COP13 rules. is an important moment for the CBD to establish ongoing governance of the field of synthetic biology. 2 Synthetic Biology and the CBD: Five key decisions for COP13 Five important issues for syn bio oversight Drawing on the advice already issued by SBSTTA 20 In online comments during preparation of the AHTEG and the AHTEG on Synthetic Biology [SBSTTA on risk assessment (under the Cartagena Protocol) some recommendation XX/8], parties preparing for COP13 Parties used the absence of an agreed operational should reflect on the following four priority topics: definition an synthetic biology as an argument against examining the risk assessment of synthetic biology. It 1. Operational Definition would be obstructive and wasteful if Parties at of Synthetic Biology COP13 deliberately fail to adopt a In online definition for use within the CBD and Parties at COP12 requested an comments during its protocols. If Parties are concerned operational definition of synthetic preparation of the AHTEG on that the definition provided is too biology to support ongoing work risk assessment (under the broad, then the AHTEG could be on this topic, but unless that Cartagena Protocol) some Parties instructed to develop a definition is formally adopted by used the absence of an agreed supplementary ‘living list’ or annex COP13 as an operational operational definition of synthetic naming techniques and approaches definition for the work within the biology as an argument against that either are or are not commonly CBD, future work will be examining the risk assessment regarded as part of the field of unnecessarily obstructed. of synthetic biology. synthetic biology. Such an open and At COP 12, parties to the CBD non-exhaustive list of included and instructed the AHTEG on Synthetic Biology excluded techniques and approaches could to draw on the work of the open online forum to work draw on existing literature such as CBD Technical towards an operational definition of synthetic biology. Series no. 82. The annex would also make clear that Establishing a definition is vital to future work on this techniques for genome editing and genome synthesis are topic. After a lot of hard work and drawing on extensive expressly covered by the definition under a positive list. definitional surveys the AHTEG provided the following definition: 2. Precaution: Gene Drives “Synthetic biology is a further development and Gene drives, which can drive a trait through an entire new dimension of modern biotechnology that population, eradicating or altering entire populations combines science, technology and engineering to and species, have quickly emerged as an extremely facilitate and accelerate the understanding, design, high risk synthetic biology application since the last redesign, manufacture and/or modification of COP. Proposals for near term environmental release genetic materials, living organisms and biological of gene drives into field trials are already on the table. systems.” Parties at COP should agree a moratorium on field trials or deployment of gene drives pending further Unfortunately, SBSTTA 16 failed to unambiguously work. They must also address the risk of unintended propose adoption of this definition. Instead, the advice and accidental release from laboratories. sent by SBSTTA to COP provides two alternative A ‘gene drive’ refers to a genetic engineering bracketed paragraphs. The first merely notes that the technology that aims to ensure that a specific trait definition was developed, the second clearly proposes to introduced into an organism (e.g. female sterility, colour, use the definition for future work. COP 13 should size, behaviour) is always or mostly passed on to future clearly adopt the definition for future use. The absence generations. The effect of a successful gene drive is that a of an agreed operational definition has already begun to single engineered trait can be driven through an entire obstruct work on this topic under the CBD and its population until it either takes over or crashes that Protocols. population. International Civil Society Working Group on Synthetic Biology (ICSWGSB) 3 This has the potential to affect the entire species, ie. take In June 2016, a 200-page report on gene drive it over or cause it to go extinct. Gene drives open up a a governance released by the US National Academy of new field of species-wide population engineering where Sciences (NAS) stressed the need for precaution and the introduction of just one fast-reproducing organism ecological assessments, noting the lack of governance (e.g. insects, plants, small mammals, parasites) can arrangements and that “there is insufficient evidence deliberately alter entire ecosystems. The implications for available at this time to support the release of
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