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Science. 302 (5649): 1364 (5649): 302 Science.accuracy". level Dantas G, Ireton GC, GC, Ireton G, Varani : G,BL, Stoddard Baker D – 8. 8. • • • • • • • Applications Drug delivery platforms life Synthetic Astrobiology / exploration Space biomolecules Designed transformation Cell Biosensors computers Biological https://en.wikipedia.org/wiki/Synthetic_biology bio = Ribosome : - machine 3 National Science Foundation-CMP/DMR • • (fats) lipids~35,000 Artificial lipids? Role interfaces? at many? so Why • • Everything right of problem The Boot mirror: a has Everything Origin? Why? - up a left - handed cell? chirality - handed: 4 National Science Foundation-CMP/DMR (a sub Multidisciplinary Traditionalare that materials on research • • • • • • FEATURES years old. 50 ~ science a As Problem/Application Driven Problem/Application Biomotors (keratin - Biopolymers Driven Applications Structural Hierarchy Self Bioactivity / Compatibility - - assembly area Soft of : (kinesin) - (polymers, etc.(polymers, ceramics,composites, metals, Condensed Matter Physics) protein, chitin/cellulose chitin/cellulose protein, – inorganic materials inorganic from biology from or - for biology for polysaccharide) 5 National Science Foundation-CMP/DMR • • • Profound fundamental questions: • • Volume 44 Far Bioinspired are ubiquitous in biology. are equilibrium of that out states dynamical structured Highly structures. condensed static exploresuniform, equilibrated Traditional science materials Biomachines Emergence and Matter Active Information andComplexity Far ) biocomposites on seashells; (concrete mimicking Biomimicry - - from - Issue 2 - 2 Issue equilibrium Thermodynamicsequilibrium -From that never were never that February 2019 Equilibrium Materials Materials -Equilibrium - matter matter - demand demand 6 National Science Foundation-CMP/DMR • GOALS: • • • Foundation To foster way a that in inquiry To train generationnext researchers the to approachof scientific To new develop scales all across interactions and identify biological Tounderstand better to us allow will discoveries that enable collaboration and collaboration research convergent research tools and infrastructure research tools – so - crosses scales and scientific disciplines and scientific crosses scales called "rules" for functions how life causal, predictive relationships relationships predictive causal, across the across 7 National Science Foundation-CMP/DMR • • SOME CHARACTERISTICS: • • system the Enables formulated becan under a investigation, so that rule system be will that Generatesresults biologicalorganization, andcomplexity) scales different vastly Crosses Addresses a forecasting/prediction of change of forecasting/prediction fundamental question fundamental broadly generalizablebroadly (spatial, temporal, of (spatial, levels in the life sciences life the in in ain biological beyond the the beyond 8 National Science Foundation-CMP/DMR WHY? 9 National Science Foundation-CMP/DMR • URoL CURRENT: • • • • • Planning for FY20 to FY23 are underwayFY23 are FY20 toforPlanning URoL and validating synthetic cells that express specified phenotypes specified expressthat cells and synthetic validating multidisciplinary Proposals under review MPS ENG, BIO, Ideas Lab Proposals under review MPS ENG, BIO, broad workforce area the trainingand epigenetics. of in education Toinnovative enable to promote research and : Epigenetics : Epigenetics : Building a Synthetic Cell Cell a : Building Synthetic to facilitate the generation innovativeof and execution facilitate to research projects aimed at designing, fabricating, fabricating, at designing, aimed research projects (NSF 18 (NSF - 600) $15M (NSF 18 (NSF - 599) $15M multidisciplinary 10 National Science Foundation-CMP/DMR MATHEMATICS: Joint Initiatives Initiatives Joint MATHEMATICS: understanding of the molecular underpinnings of life processes. Focus and biology, of chemistry on interface research at the CHEMISTRY: CHEMISTRY OF LIFEPROCESSES (CLP) to perform their functions in dynamic and diverseenvironments. utilize systems living that processes physical Focus fundamental on PHYSICS: PHYSICS OF LIVINGSYSTEMS ( • • MATERIALS RESEARCH: RESEARCH: MATERIALS (HDR) Research (DMS/NLM) Biomedical for Methods Science on Data Generalizable Initiative (DMS/NIGMS) Sciences and Mathematical Research to Support Biological the of Initiative Interface at the SQUARE BIOMATERIALS(BMAT) + SOFT (CMP & CMMT) -TABLE ( ST ) Concept – Harnessing the Data Rev. PoLS ) 11 National Science Foundation-CMP/DMR Decommission ( Discovery Degrade) 4D Develop Deploy 12 National Science Foundation-CMP/DMR Synthetic Biology Community DoD, DARPA, (NSF,NIH, NASA, Funding Funding Agencies Synth Convergence BioMaterials Community - Bio - Mat etc ) Industry RepIndustry / (FDA, EPA) Regulators Federal 13 National Science Foundation-CMP/DMR SQUARE FDA; NASA; DARPA;AFOSR NSF (BMAT,CMP, CBET, MCB,CHE); PHY, NIST; NIH -NIBIB; real.knowledge makes that RESEARCH: our The MATERIALS palette • • Follow up - ST1 o o o o o o o o Institutes) to develop develop to Institutes) ST3 ST2 selfEncourage half Final Mix/Remix of Researchers,Regulators, Program Directors, etc. Repeat Reportto back entire group breakout around questionsguiding Discussion ( 2018: Experimental format; format; Experimental 2018: -TABLE - - 2019: Convergence of existing major efforts (Centers and 2019: ST - day produce draftproduceday of outcomes meetings thru MULTIPLIERthru meetings support: Programmable Interfaces ( ST - assembly! ): bridging bridging ): Research Collaborative Networks Collaborative Research and and Biology Synthetic Living Interfaces Living real squarereal tables Biomaterials Biomaterials ) 14 National Science Foundation-CMP/DMR 15 National Science Foundation-CMP/DMR • • • • • • • Relying on inherent biological mechanisms biological inherent on Relying responsesmodulatesystems to biological and biomaterials between interface the Designing scales all at matter of the organization Controlling functionalities Emulatingnature fornew materialswith unique New experimental and theoretical techniques theoretical and experimental New Improvedstandard “gold” Connectingnon- to biological mechanisms biological 16 National Science Foundation-CMP/DMR • • • • • Potential “Moon New/Augmented Compositions Functions of Classes New Review Articles / Articles Review Blue o o o o o o o o o Reinvented Feedstockrenewables include to cells include to Reinvented Composites Evolve that Materials Non Communicate that Materials Bio Body the in Materials Matter Incorporate Living that Materials Self - Print / Road - - - Reference Materials healing/Restructuring Materials Equilibrium Materials Equilibrium - Shots” - Whitepapers Map Recommendations (under review) (under 17 National Science Foundation-CMP/DMR NEED: The The STRATEGY: hard on not heads people’s … point focal a provide It would need. external and internal the both address could Biomaterials of MPS subcommittee A SOLUTION: Externally Internally valuable what the is BUT Efforts extremely Bigis opportunities for MPS. for opportunities on advise help this areain and the current activities representationtheMPS of SynthBioMat The wide diversity of Perspectives, Disciplines, Disciplines, Perspectives, of diversity wide The : Broad MPS efforts efforts MPS Broad : : Cross : - Subcommittee, composed of a broad a broad of composed Subcommittee, NSF activities - AC focusedSynthetic on Biology& - AC, would be tasked to review - drives. – Who sees it all? it sees Who – How coordinate? to How best these ideas live in - Picture? 18