New Brunswick Prescription Drug Program Formulary

Total Page:16

File Type:pdf, Size:1020Kb

New Brunswick Prescription Drug Program Formulary NEW BRUNSWICK PRESCRIPTION DRUG PROGRAM FORMULARY Copyright - 2003 The Queen In the right of The Province of New Brunswick as represented by The Honourable Elvy Robichaud Minister of Health and Wellness ADMINISTERED BY ATLANTIC BLUE CROSS CARE ON BEHALF OF THE GOVERNMENT OF NEW BRUNSWICK TABLE OF CONTENTS Page Introduction to the New Brunswick Prescription Drug Program Formulary I The New Brunswick Prescription Drug Program I New Brunswick Prescription Drug Program Plans II - III Exclusions IV - V Extemporaneous Preparations and Placebos VI Benefit Review Process VII Product Deletion VII Submission Requirements VIII Legend IX Comment Sheet X Pharmacologic - Therapeutic Classification of Drugs 4:00 Antihistamines 1 8:00 Anti-Infective Agents 3 10:00 Antineoplastic Agents 28 12:00 Autonomic Drugs 33 20:00 Blood Formation and Coagulation 43 24:00 Cardiovascular Agents 49 28:00 Central Nervous System Agent 76 40:00 Electrolytic, Caloric and Water Balance 128 48:00 Antitussives, Expectorants & Mucolytic Agents 133 52:00 Eye, Ear, Nose and Throat (EENT) Preparations 135 56:00 Gastrointestinal Drugs 149 60:00 Gold Compounds 159 64:00 Heavy Metal Antagonists 160 68:00 Hormones and Synthetic Substitutes 161 80:00 Serums, Toxoids, and Vaccines 179 84:00 Skin and Mucous Membrane Agents 180 86:00 Smooth Muscle Relaxants 198 88:00 Vitamins 201 92:00 Unclassified Therapeutic Agents 205 TABLE OF CONTENTS Page Appendices I-A Abbreviations of Dosage Forms A-1 - A-3 I-B Abbreviations of Routes A-4 - A-5 I-C Abbreviations of Units A-6 - A-7 II Abbreviations of Manufacturers' Names A-8 - A-9 III Extemporaneous Preparations A-10 IV Special Authorization A-11 IV Special Authorization Drug Criteria A-12 NEW BRUNSWICK PRESCRIPTION DRUG PROGRAM FORMULARY Introduction The New Brunswick Prescription Drug Program Formulary is a listing of all drugs and drug products which have been determined by the Minister of Health and Wellness to be entitled services. Such drugs and drug products must be listed in the New Brunswick Prescription Drug Program Formulary, in order to be considered current eligible benefits. Entitled services which are considered to be interchangeable and available for product selection are noted. The drugs are listed by Therapeutic Category in accordance with that established by the AHFS Drug Information. Each entry is cross-indexed by trade name, generic name and drug identification number (DIN). The New Brunswick Prescription Drug Program Formulary is updated quarterly and produced once yearly on compact disc (CD). Each provider pharmacy and authorized dispensing physician is provided with an electronic copy of the publication on (CD). An electronic copy on CD is available upon request to all physicians registered with Medicare. An electronic copy in Portable Document Format (PDF) is also maintained on the NBPDP web page; http://www.gnb.ca/0051/0212/index-e.asp. To have your name added to the e-mail mailing list to receive an electronic copy, please send a message to [email protected]. New Brunswick Prescription Drug Program The Prescription Drug Program was established to improve and maintain the well-being of the people of the province by making available specified drugs to selected target groups. The program is monitored by the Advisory & Utilization Committee which includes representatives of the health care professionals involved, department administration and laypersons. This committee makes recommendations to the Minister of Health and Wellness on the addition and deletion of benefits to the various plans. I June 2003 New Brunswick Prescription Drug Program Plans Participating Legislative Plans Fees Beneficiaries Authority A $9.05 per prescription up to an Eligible residents of the province Prescription Drug annual copay ceiling of $250 who are sixty-five years of age Payment Act and for GIS recipients. or older Regulations $15.00 per prescription with no annual ceiling for non-GIS recipients B $50 per year registration fee(1); Persons with cystic fibrosis who Prescription Drug 20% of cost of prescription to a are eligible residents and Payment Act and maximum of $20 per registered with the Department Regulations prescription up to an annual of Health and Wellness ceiling of $500 per family unit E $4 per prescription; up to an Persons in licensed residential Health Services annual copay ceiling of $250 facilities who are in receipt of Act and per person(2) financial assistance from the Regulations Department of Family & Community Services and hold a valid health card issued by Family & Community Social Services F $4 per prescription for adults Family and Community Services Health Services (18 years and over) clients Act and $2 per prescription for children Regulations (under 18 years); up to an annual copay ceiling of $250 per family unit(2) G None Children in care of the Minister Health Services of Health and Wellness and Act and special needs children Regulations H $50 per year premium; copay Persons with multiple sclerosis Prescription Drug ranges from zero to 100 per who are eligible residents and Payment Act and cent for each prescription registered with the Department Regulations of Health and Wellness R $50 per year registration fee(1); Solid organ transplant recipients Prescription Drug 20% of cost of prescription to a who are eligible residents and Payment Act and maximum of $20 per registered with the Department Regulations prescription up to an annual of Health and Wellness ceiling of $500 per family unit II June 2003 New Brunswick Prescription Drug Program Plans Participating Legislative Plans Fees Beneficiaries Authority T $50 per year registration fee(1); Persons with growth hormone Prescription Drug 20% of cost of prescription to a deficiency who are eligible Payment Act and maximum of $20 per residents and registered with the Regulations prescription up to an annual Department of Health and ceiling of $500 per family unit Wellness U $50 per year registration fee(1); HIV-infected persons who are Prescription Drug 20% of cost of prescription to a eligible residents and registered Payment Act and maximum of $20 per with the Department of Health Regulations prescription up to an annual and Wellness ceiling of $500 per family unit V None Eligible residents of Nursing Prescription Drug Homes as defined in the Nursing Payment Act and Home Act operated by a licensee Regulations under the Act Special Plan dependent (3) Persons approved to have Prescription Drug Authorization payment made for certain drugs Payment Act following medical consultation Non-NBPDP Participating Legislative Fees Plan Beneficiaries Authority W $9.05 per prescription Extra Mural Hospital patients Hospital Services who are in possession of a Act Prescription Drug Authorization Form (1) Family and Community Services clients are exempted from these fees. (2) Exempted from these fees for oral contraceptives. (3) See Appendix IV. III June 2003 Exclusions While only products listed in the New Brunswick Prescription Drug Program Formulary are benefits the following are some of the specific products not included: 1. Patent medicines such as Jack and Jill Cough Syrup, Extract of Wild Strawberry, etc. 2. Non-prescription acetylsalicylic acid (ASA) preparations except enteric coated ASA products designated as benefits. 3. Non-prescription mouth, throat and nasal preparations, including decongestants 4. Prescription and non-prescription, Cough and Cold products (antitussives, expectorants and decongestants) except those designated for children in care & Cystic Fibrosis beneficiaries. 5. (a) Non-prescription adult vitamins with or without iron supplements (Plans A, E, F [over 18 years of age]) as a dietary supplement (b) Multivitamins (prescription and non-prescription) as a dietary supplement 6. Non-prescription tonics and compounded iron preparations (except single entity iron preparations designated as benefits) 7. Dietary/nutritional supplements and food products 8. Artificial sweetening agents 9. Weight loss products (prescription and non-prescription) 10. Calcium preparations (prescription and non-prescription) as a dietary supplement 11. Laxatives (Plans A, E,F and G) 12. Antacids (Plans A only) 13. Smoking cessation products 14. Ergoloid mesylates, oral, (Hydergine) 15. Potassium supplements, oral, when supplied as K-Lyte effervescent tablets, lime or orange flavoured 16. Retinoic acid (eg. Tretinoin) topical and oral preparations (Plan A only) 17. Cosmetic, health, dental and beauty aids, and cosmetic drugs 18. Soaps, cleansers and shampoos, medicated or otherwise 19. Appliances, prosthetic or otherwise, including first aid supplies and syringes IV June 2003 20. Diagnostic agents 21. Household remedies e.g. calamine lotion, iodine, hydrogen peroxide, antiseptics and disinfectants 22. Injectables or other products normally administered in a hospital setting or requiring a health care professional for administration and/or monitoring to ensure the appropriate standard of patient care is provided 23. Any insured service for which the resident is entitled to benefit under Department of Veterans Affairs, Workplace Health & Safety Compensation Commission or other legislation 24. Delivery, postal or C.O.D. charges 25. Refills in excess of the number specified by the physician or any refill of a prescription older than one year unless approved for refill by the prescriber 26. Antihistamines (Plans A, E, F, V and W) 27. Benzoyl Peroxide preparations in strengths of 5% or less. 28. Lactase Enzyme products. 29. All drug products used for the treatment
Recommended publications
  • Biomarkers in Glioblastoma HIVE
    Development of Integrated Imaging Techniques for Investigating Biomarkers in Glioblastoma HIVE HEISOOG KIM B.S., Nuclear Engineering (2004) Seoul National University M.D. Certificate, Graduate Education in Medical Sciences (2011) Harvard-MIT Division of Health Sciences and Technology SUBMITTED TO THE DEPARTMENT OF NUCLEAR SCIENCE AND ENGINEERING IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN NUCLEAR SCIENCE AND ENGINEERING AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY SEPTEMBER 2011 @ 2011 Massachusetts Institute of Technology All rights reserved Signature of Author: Heisoog Kim Department of Nuclear Science and Engineering A.. ust 8"', 2011 Certified by Bruce R. n, Professor of Health Science and Technology/Nuclear Engineering All/7 Thesis Supervisor Certified by A. Gregory Sorensen, Professor at Harvard Medical School, Thesis Supervisor Reviewed by Elfar Adalsteinsson, Associate professor of Health Science and Technology, Thesis Reader Accepted by Mujid S. Kazimi, TEPCO P fess f Nuclear Engineering Chair, Department Committee on Graduate Students Table of Contents Abstract 5 Acknowledgements 7 List of Figures 9 List of Tables 11 1. Introduction 15 1.1. Significance of Developing Biomarkers 15 2. Cancer Physiology 19 2.1. Glioblastoma 19 2.2. Vascular Structure and Function in Brain Tumors 20 2.3. Angiogenesis in Tumor 22 2.4. Oxidative Metabolism in Tumors 23 2.5. Hypoxia in Tumors 26 3. Treatment Philosophies 33 3.1. Surgery 33 3.2. Radiotherapy 33 3.3. Chemotherapy 35 3.4. Antiangiogenic Therapy 37 4. Basics of Advanced Imaging Techniques 41 4.1. Magnetic Resonance Imaging Techniques 41 Simultaneous Blood Oxygenation Level Dependent (BOLD) and Arterial Spin Labeling (ASL) Imaging 42 Proton Magnetic Resonance Spectroscopy ('H MRS) Imaging 44 4.2.
    [Show full text]
  • Kepivance, INN-Palifermin
    SCIENTIFIC DISCUSSION 1. Introduction Oral mucositis Oral mucositis is a significant problem in patients receiving chemotherapy or radiotherapy. Estimates of oral mucositis incidence among cancer therapy patients range from 40% of those receiving standard chemotherapy to 76% of bone marrow transplant patients [1]. Virtually, all patients who receive radiotherapy to the head and neck area develop oral complications. Cancer therapy-induced mucositis occurs when radiation or chemotherapy destroys rapidly proliferating cells such as those lining the mouth, throat, and gastrointestinal tract. In the setting of high-dose myelotoxic therapy, mucositis is a frequent, extremely painful and debilitating complication [2]. Mucositis can arise along the entire gastrointestinal tract and can be associated with significant morbidity, including: pain, specifically in the oral cavity, pharynx, and esophagus (esophagitis), requiring opioid analgesia; difficulty or inability to swallow, because of ulcerations in the oral cavity, pharynx, and esophagus, leading to a compromised nutritional status necessitating parenteral feeding and hydration; infection due to the breakdown of the epithelial barrier and exacerbated by accompanying neutropenia (when present); difficulty or inability to speak; nausea, vomiting, and diarrhoea, which may require intravenous (i.v.) rehydration and may predispose the patient to severe electrolyte and acid-base disorders; gastrointestinal bleeding due to ulceration at any site of the gastrointestinal tract, authorisedbut typically in the esophagus or stomach. These manifestations diminish the quality of life of patients with cancer and can interfere with management of the primary disease, e.g., requiring dose reductions or treatment delays [3]. The effect of mucositis on length of hospital stay, admissions for fluid support or treatment of infection, and alteration of optimum anticancer treatment have significant clinical and economic consequences [4].
    [Show full text]
  • High-Dose Carmustine, Etoposide, and Cyclophosphamide Followed by Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma
    Biology of Blood and Marrow Transplantation 12:703-711 (2006) ᮊ 2006 American Society for Blood and Marrow Transplantation 1083-8791/06/1207-0002$32.00/0 doi:10.1016/j.bbmt.2006.02.009 High-Dose Carmustine, Etoposide, and Cyclophosphamide Followed by Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma Lisa Y. Law,1 Sandra J. Horning,2 Ruby M. Wong,3 Laura J. Johnston,1 Ginna G. Laport,1 Robert Lowsky,1 Judith A. Shizuru,1 Karl G. Blume,1 Robert S. Negrin,1 Keith E. Stockerl-Goldstein1 1Division of Blood and Marrow Transplantation, 2Division of Oncology, and 3Department of Health, Research and Policy, Stanford University Medical Center, Stanford, California Correspondence and reprint requests: Keith E. Stockerl-Goldstein, Division of Blood and Marrow Transplantation, 300 Pasteur Drive, H3249, Stanford University Medical Center, Stanford, CA 94305 (e-mail: [email protected]). Received August 28, 2005; accepted February 27, 2006 ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) has been shown to be curative in a group of patients with aggressive non-Hodgkin lymphoma (NHL). A previous study has demonstrated equivalent outcomes with a conditioning regimen based on total body irradiation and another not based on total body irradiation with preparative therapy using cyclophosphamide, carmustine, and etoposide (CBV) in autologous HCT. We investigated the safety and efficacy of using CBV in an allogeneic setting. Patients were required to have relapsed or be at high risk for subsequent relapse of NHL. All patients had a fully HLA-matched sibling donor. Patients received carmustine (15 mg/kg), etoposide (60 mg/kg), and cyclophosphamide (100 mg/kg) on days ؊6, ؊4, and ؊2, respectively, followed by allogeneic HCT.
    [Show full text]
  • Bicnu (Carmustine)
    Prior Authorization DRUG Guidelines Bicnu (carmustine) Effective Date: 10/22/13 Date Developed: 9/3/13 by Albert Reeves MD Last Approval Date: 1/26/16, 1/24/17, 1/23/18, 1/22/19, 2/18/20, 8/3/21 Pharmacologic Category : Antineoplastic Agent;, Alkylating Agent Preauthorization Criteria: Injection: Palliative eatment: brain tumors (glioblastoma, brainstem glioma, medulloblastoma, astrocytoma, ependymoma, and metastatic brain tumors), multiple myeloma, Hodgkin's lymphoma (relapsed or refractory), non-Hodgkin's lymphomas (relapsed or refractory) Wafer (implant): Adjunct to surgery in patients with recurrent glioblastoma multiforme; adjunct to surgery and radiation in patients with newly-diagnosed high-grade malignant glioma Dosing: Adult ; Brain tumors, Hodgkin’s lymphoma, multiple myeloma, non-Hodgkin’s lymphoma (per manufacturer labeling): I.V.: 150-200 mg/m2 every 6 weeks or 75-100 mg/m2/day for 2 days every 6 weeks Glioblastoma multiforme (recurrent), newly-diagnosed high-grade malignant glioma: Implantation (wafer): 8 wafers placed in the resection cavity (total dose 61.6 mg); should the size and shape not accommodate 8 wafers, the maximum number of wafers allowed (up to 8) should be placed Indication-specific dosing: Brain tumor, primary (unlabeled doses): I.V.: 80 mg/m2/day for 3 days every 8 weeks for 6 cycles (Brandes, 2004) 200 mg/m2 every 8 weeks [maximum cumulative dose: 1500 mg/m2] (Selker, 2002) Hodgkin’s lymphoma, relapsed or refractory (unlabeled dose): I.V.: Mini-BEAM regimen: 60 mg/m2 day 1 every 4-6 weeks (in combination
    [Show full text]
  • Appendix C Medication Tables
    Appendix C Medication Tables Note: The medication tables are not meant to be inclusive lists of all available therapeutic agents. Approved medication tables will be updated regularly. Discrepancies must be reported. See Resource Section of this manual for additional contact information. Release Notes: Aspirin Table Version 1.0 Table 1.1 Aspirin and Aspirin-Containing Medications Acetylsalicylic Acid Acuprin 81 Alka-Seltzer Alka-Seltzer Morning Relief Anacin Arthritis Foundation Aspirin Arthritis Pain Ascriptin Arthritis Pain Formula ASA ASA Baby ASA Baby Chewable ASA Baby Coated ASA Bayer ASA Bayer Children's ASA Buffered ASA Children's ASA EC ASA Enteric Coated ASA/Maalox Ascriptin Aspergum Aspir-10 Aspir-Low Aspir-Lox Aspir-Mox Aspir-Trin Aspirbuf Aspircaf Aspirin Aspirin Baby Aspirin Bayer Aspirin Bayer Children's Aspirin Buffered Aspirin Child Aspirin Child Chewable Aspirin Children's Aspirin EC Aspirin Enteric Coated Specifications Manual for National Appendix C-1 Hospital Quality Measures Table 1.1 Aspirin and Aspirin-Containing Medications (continued) Aspirin Litecoat Aspirin Lo-Dose Aspirin Low Strength Aspirin Tri-Buffered Aspirin, Extended Release Aspirin/butalbital/caffeine Aspirin/caffeine Aspirin/pravachol Aspirin/pravastatin Aspirtab Bayer Aspirin Bayer Aspirin PM Extra Strength Bayer Children’s Bayer EC Bayer Enteric Coated Bayer Low Strength Bayer Plus Buffered ASA Buffered Aspirin Buffered Baby ASA Bufferin Bufferin Arthritis Strength Bufferin Extra Strength Buffex Cama Arthritis Reliever Child’s Aspirin Coated Aspirin
    [Show full text]
  • DRUG NAME: Cyclophosphamide
    Cyclophosphamide DRUG NAME: Cyclophosphamide SYNONYM: Cyclo, CPA, CPM, CTX, CYC, CYT COMMON TRADE NAME: CYTOXAN®,1 PROCYTOX®, NEOSAR® (USA) CLASSIFICATION: Alkylating agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Cyclophosphamide is an alkylating agent of the nitrogen mustard type.2 An activated form of cyclophosphamide, phosphoramide mustard, alkylates, or binds, to DNA. Its cytotoxic effect is mainly due to cross-linking of strands of DNA and RNA, and to inhibition of protein synthesis.3 These actions do not appear to be cell-cycle specific. PHARMACOKINETICS: Interpatient variability metabolism; clearance of cyclophosphamide and its metabolites4 Oral Absorption >75%2; manufacturer recommends drug be taken on an empty stomach, but states may be taken with food to decrease GI upset5 time to peak plasma 1-2 h3 concentration Distribution throughout body cross blood brain barrier? to limited extent2 volume of distribution 0.56 L/kg6 plasma protein binding7 12-14% of unchanged drug; 67% of total plasma alkylating metabolites6 Metabolism mainly by microsomal enzymes in the liver;8 cytochrome P450 (CYP) primarily CYP 2B69 active metabolites4 4-hydroxycyclophosphamide, aldophosphamide, phosphoramide mustard, acrolein10 inactive metabolites4 4-keto-cyclophosphamide, carboxyphosphamide, nornitrogen mustard Excretion primarily by enzymatic oxidation to active and inactive metabolites, which are mainly excreted in the urine7 urine 5-25% unchanged2 feces 31-66% after oral dose terminal half life7 6.5 h (1.8-12.4 h) clearance7 1.17 mL/min/kg Gender no clinically important differences found Elderly no clinically important differences found Children terminal half life 2.4-6.5 h7; volume of distribution 0.67 L/kg7 Ethnicity no clinically important differences found Adapted from standard reference11 unless specified otherwise.
    [Show full text]
  • Aspects Anatomocliniques Et Évolutifs
    UNIVERSITE CADI AYYAD Lymphome hodgkinien : aspects anatomocliniques FACULTEet évolutifs DE MEDECINE ET DE PHARMACIE MARRAKECH ANNEE 2010 THESE N° 72 LYMPHOME HODGKINIEN : Aspects anatomocliniques et évolutifs THESE PRESENTEE ET SOUTENUE PUBLIQUEMENT LE …/…/2010 PAR Mlle. Hanan RAISS Née le 05 Septembre 1983 à Tafraout POUR L'OBTENTION DU DOCTORAT EN MEDECINE MOTS CLES Maladie de Hodgkin – Adénopathie – Anatomie pathologique JURY Mr. A. OUSEHAL PRESIDENT Professeur de Radiologie Mme. B. BELAABIDIA RAPPORTEUR Professeur d’Anatomie Pathologique Mr. O. ESSADKI Professeur de Radiologie Mme. L. ESSAADOUNI JUGES Professeur agrégé en Médecine Interne Mr. L. MAHMAL Professeur agrégé en Hématologie Clinique Lymphome hodgkinien : aspects anatomocliniques et évolutifs ″ﺭﺏ ﺃﻭﺯﻋﻨﻲ ﺃﻥ ﺃﺷﻜﺮ ﻧﻌﻤﺘﻚ ﺍﻟﺘﻲ ﺃﻧﻌﻤﺖ ﻋﻠﻲَ ﻭﻋﻠﻰ ﻭﺍﻟﺪﻱَ ﻭﺃﻥ ﺃﻋﻤﻞ ﺻﺎﻟﺤﺎ ﺗﺮﺿﺎﻩ ﻭﺃﺻﻠﺢ ﻟﻲ ﻓﻲ ﺫﺭﻳﺘﻲ ﺇﻧﻲ ﺗﺒﺖ ﺇﻟﻴﻚ ﻭﺇﻧﻲ ﻣﻦ ﺍﻟﻤﺴﻠﻤﻴﻦ″ . ﺻﺪﻕ ﺍﷲ ﺍﻟﻌﻈﻴﻢ Lymphome hodgkinien : aspects anatomocliniques et évolutifs Lymphome hodgkinien : aspects anatomocliniques et évolutifs Liste des professeurs Lymphome hodgkinien : aspects anatomocliniques et évolutifs UNIVERSITE CADI AYYAD FACULTE DE MEDECINE ET DE PHARMACIE MARRAKECH Doyen Honoraire : Pr. Badie-Azzamann MEHADJI ADMINISTRATION Doyen : Pr. Abdelhaq ALAOUI YAZIDI Vice doyen : Pr. Ahmed OUSEHAL Secrétaire Général : Mr. Azzeddine EL HOUDAIGUI PROFESSEURS D’ENSEIGNEMENT SUPERIEUR ABBASSI Hassan Gynécologie-Obstétrique A AIT BENALI Said Neurochirurgie ALAOUI YAZIDI Abdelhaq Pneumo-phtisiologie ABOUSSAD Abdelmounaim Néonatologie BELAABIDIA Badia Anatomie-Pathologique
    [Show full text]
  • Autologous Stem Cell Transplantation for High-Risk Hodgkin's Disease
    Haematologica 2000; 85:167-172 Transplantation & Cell Therapy original paper Autologous stem cell transplantation for high-risk Hodgkin’s disease: improvement over time and impact of conditioning regimen MARICEL SUBIRÀ, ANNA SUREDA, RODRIGO MARTINO, JOAN GARCÍA,* ALBERT ALTÉS, CARME CANALS, ANDREU DOMINGO-ALBÓS,† SALUT BRUNET, JORGE SIERRA Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, *Cryobiology and Cellular Therapy Department, Can- cer Research Institute, Barcelona, Spain †Deceased ABSTRACT Background and Objectives. High-dose chemo/radio- p to 80% of patients with advanced Hodgkin’s therapy with autologous stem cell support is increas- disease (HD) can be cured by combination 1 ingly being used in Hodgkin’s disease (HD) patients Uchemotherapy (CT). Despite these encour- who do not respond to or who relapse after conventional aging overall results, patients refractory to the initial chemotherapy. In this work we analyze the results of 56 treatment and those relapsing after an initial consecutive high-risk HD patients autografted in our response frequently cannot be cured by convention- institution and the role of possible prognostic factors. al therapy with only 20% becoming long-term dis- ease-free survivors.2,3 These poor results led us toin- Design and Methods. There were 34 males and 22 vestigate the efficacy of high-dose therapy followed females with a median age of 31 years. At transplan- by autologous stem cell transplantation (ASCT) in tation, 24 patients (43%) were in complete remission this population. ASCT in poor prognosis HD and 32 (57%) were autografted while with active dis- patients has been reported by several authors to give ease.
    [Show full text]
  • United States Patent (10) Patent No.: US 9,605,003 B2 Castro Et Al
    USOO9605 003B2 (12) United States Patent (10) Patent No.: US 9,605,003 B2 Castro et al. (45) Date of Patent: Mar. 28, 2017 (54) HETEROCYCLIC COMPOUNDS AND USES 5,294,612 A 3, 1994 Bacon et al. THEREOF 5,310,731 A 5/1994 Olsson et al. 5,364,862 A 11/1994 Spada et al. 5,420,419 A 5, 1995 Wood (71) Applicant: Infinity Pharmaceuticals, Inc., 5,428,125 A 6/1995 Hefner, Jr. et al. Cambridge, MA (US) 5,442,039 A 8/1995 Hefner, Jr. et al. 5,504,103 A 4/1996 Bonjouklian et al. (72) Inventors: Alfredo C. Castro, Woburn, MA (US); 5,506,347 A 4/1996 Erion et al. Catherine A. Evans, Somerville, MA 3: A 1999. St. al (US); Andre Lescarbeau, Somerville, 5.593.997 A 1/1997 f MA (US); Tao Liu, Wellesley, MA 5,646,128. A 7/1997 Firestein et al. (US); Daniel A. Snyder, Somerville, 5,652,366 A 7/1997 Spada et al. MA (US); Martin R. Tremblay, 39 A s 3. E. et al Melrose, MA (US); Pingda) Ren, San 5,674,998. A 10/1997 Boyeragwat et al.et al. Diego, CA (US); Yi Liu, San Diego, 5,686,455. A 1 1/1997 Adams et al. CA (US); Liansheng Li, San Diego, 5,736,554. A 4/1998 Spada et al. CA (US); Katrina Chan, Fremont, CA 5,747,235 A 5/1998 Farid et al. (US) 5,756,711 A 5/1998 Zilch et al. 5,763,596 A 6/1998 Boyer et al.
    [Show full text]
  • Chemotherapy Drugs
    CHEMOTHERAPY, DRUGS, AGENTS- This document contains three lists: 1) Individual drugs/agents 2) Known protocols 3) Old protocol descriptions Each table has the name of the drug, the code by which it is represented in the database, and the name by which this drug appears in the database if the drug can be known by more than one name. 1. Individual drugs/agents Drug Name (synonym) Code Name in database 2-CdA 63 2-CdA 4-demethoxydaunorubicin 18 Idarubicine 5- Fluorouracil 20 Fluorouracil 5FU 20 Fluorouracil 6-mercaptopurine 22 Mercaptapur6 6-MP 22 Mercaptapur6 Acridinyl anisidide 2 Amsacrine Actinomycin D 65 Dactinomycin Acyclovir 311 Acyclovir Adcetris 666 Brentuximab (Adcetris) Adriamycine 1 Adriamycine Adriblastin 1 Adriamycine Advagraf 52 Tacrolimus Agrylin 351 Anagrelide Aldesleukin 206 IL-2 Alemtuzumab 632 Campath (CD52, Alemtuzumab) Alexan 3 ARA-C / Cytarabine ALG 35 ALG Alkeran 21 Melphalan AMD-3100 36 Plerixafor Amethopterin 23 Methotrexate Amikin 326 Amikin AML like therapy 43 AML like therapy AMSA P-D 2 Amsacrine Amsacrine 2 Amsacrine Anagrelide 351 Anagrelide Analgesics 88 Analgesics Androgens 39 Androgens Anthracycline 57 Anthracycline Anti IL6 643 Anti IL6 anti rIL2 (CD25) 636 anti rIL2 (CD25) Anti tumour necrosis factor (TNF) 639 Anti tumour necrosis factor (TNF) Anti-GD2 644 Anti-GD2 antiLFA1 635 antiLFA1 Antilymphocyte globulin 35 ALG Anti-malarial 56 Anti-malarial Antimetabolites 93 Antimetabolites Antithymocyte globulin 34 ATG ARA-C 3 ARA-C Aranesp (Darbepoetin) 85 Aranesp (Darbepoetin) Aredia 82 Pamidronate Arranon 342
    [Show full text]
  • Carmustine Replacement in Intensive Chemotherapy Preceding Reinjection of Autologous Hscs in Hodgkin and Non-Hodgkin Lymphoma: a Review
    Bone Marrow Transplantation (2017) 52, 941–949 © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 0268-3369/17 www.nature.com/bmt REVIEW Carmustine replacement in intensive chemotherapy preceding reinjection of autologous HSCs in Hodgkin and non-Hodgkin lymphoma: a review G Damaj1,2, J Cornillon3, K Bouabdallah4, R Gressin5, S Vigouroux3, T Gastinne6, F Ranchon7, H Ghésquières8, G Salles8, I Yakoub-Agha9 and E Gyan10 for Lymphoma Study Association and the French Society of Bone Marrow Transplantation and Cellular Therapy High-dose chemotherapy preceding autologous hematopoietic stem cell transplantation (auto-HSCT) is one treatment option for patients with Hodgkin (HL) or non-Hodgkin lymphoma (NHL). The most frequently used intensive chemotherapy is a combination of carmustine (BCNU), etoposide, cytarabine and melphalan (BEAM). However, BCNU is consistently in short supply, and there has been a recent dramatic increase in its cost, necessitating the utilization of conditioning alternatives. The busulfan-based conditioning regimen known as the busulfan–cyclophosphamide–etoposide (BuCyE) combination is the second most-studied conditioning regimen worldwide after BEAM, and it exhibits a benefit/risk ratio that is comparable to that of BEAM. In addition to these two combinations, the present manuscript also summarizes data reported for other conditioning combinations. Owing to the lack of prospective and comparative studies, a comparison of the toxicities and medicoeconomical profiles of these treatments is warranted to identify effective replacements for BCNU-based conditioning. Bone Marrow Transplantation (2017) 52, 941–949; doi:10.1038/bmt.2016.340; published online 23 January 2017 INTRODUCTION prospective study of patients who underwent transplant as a first 10 Intensive chemotherapy followed by autologous hematopoietic response.
    [Show full text]
  • Research Article Effects of Rutin and Quercetin on Doxorubicin-Induced
    Advances in Animal and Veterinary Sciences Research Article Effects of Rutin and Quercetin on Doxorubicin-Induced Renocardiotoxicity in Male Wistar Rats HEBA UALLAH R. MAHMOUD, OSAMA M. AHMED, HANAA I. FAhim, NOHA A. AHMED*, MOHAMED B. ASHOUR Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt. Abstract | This study aims to assess the preventive effects of rutin and/or quercetin on doxorubicin-induced kidney and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats, injected with doxorubicin at an intraperitoneal dose 2 mg/kg b.w. 2 days per week for 5 weeks, were orally treated with rutin and/or quercetin with dose level 50 mg /kg b.w. every other day for 5weeks. The treatments of doxorubicin-injected rats with rutin, quercetin and their combination resulted in a significant decrease in the elevated serum creatinine and urea levels reflecting an improvement in kidney function. Similarly, the elevated serum CK-MB and LDH activities were significantly ameliorated as a result of treatments of doxorubicin-injected rats, thereby manifesting an amendment of heart function. The treatments also led to the prevention of the elevated lipid peroxidation and amelioration of the lowered GPx, GST and SOD activities as well as GSH content in kidney and heart as a result of treatment of doxorubicin-injected rats with rutin and quercetin. Also, the treatments remarkably improved doxorubicin-induced deleterious histological alterations in kidney and heart. In conclusion, rutin and/or quercetin may have chemopreventive potentials against doxorubicin-induced nephrocardiotoxicity via suppression of oxidative stress and enhancement of antioxidant defense system.
    [Show full text]