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Environmental Genomics: Mechanisms and Approaches for Genomic Integrity

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SEPTEMBER 12-16, 2020 VIRTUAL MEETING ENVIRONMENTAL GENOMICS: MECHANISMS AND APPROACHES FOR GENOMIC INTEGRITY Applied Genetic Toxicology Gentoxicity Risk and Public Health DNA Repair & Mutagenic Mechanisms (GRAPH) Epigenomics Germ Cell and Heritable Effects Genomics and Data Sciences In Vivo Mutagenesis William Kaufmann, PhD EMGS President Joann B. Sweasy, PhD EMGS Program Chair Aishwarya Prakash, PhD New Investigator Co-Chair KEYNOTE SPEAKERS Kari Stefansson, M.D. Joan A. Steitz, PhD Dr. Med. CEO of deCODE Genetics Sterling Professor of Molecular Biophysics and Biochemistry Yale School of Medicine Serena Nik-Zainal, PhD University of Cambridge www.emgs-us.org/p/cm/ld/fid=501 SPONSORS OF THE 51ST VIRTUAL ANNUAL MEETING Diamond Escher Family Fund US Food and Drug Administration Grant No. 1R13FD006702-02 Platinum Merck DNA Repair Fundamental and Molecular Mechanisms of Mutagenesis Reviews in Mutation Research Genetic Toxicology and Environmental Mutagenesis Silver Bristol-Myers Squibb Gilead Sciences Research Institute for Fragrance Materials, Inc. (RIFM) Teijin Pharma Limited ILS, Inc. Bronze New England Biolabs Nucleic Acids Research NAR Cancer General National Institute of Environmental Health Sciences 3 51ST ANNUAL MEETING Synergistic Interactions for a Better World Environmental Genomics: Mechanisms and Approaches for Genomic Integrity September 12-16, 2020 VIRTUAL MEETING EMGS President: William Kaufmann, PhD EMGS Program Chair: Joann B. Sweasy, PhD New Investigator Co-Chair: Aishwarya Prakash, PhD Environmental Mutagenesis and Genomics Society 12627 San Jose Blvd., Suite 202 | Jacksonville, Florida 32223 Telephone: 904.289.3410 | Fax: 904.513.2666 Email: [email protected] | EMGS Website: https://www.emgs-us.org EMGS Program Abstracts printed in Environmental and Molecular Mutagenesis Volume 61, Number S1 The Environmental Mutagenesis and Genomics Society was founded in 1969 and is incorporated under the laws of the District of Columbia. Its purpose is to encourage the study of mutagens in the human environment, particularly as they may affect public health, and to engage in and sponsor research and the dissemination of information related to mutagens. Membership is open to all interested scientists. https://www.emgs-us.org/page/emgsmembership All text and graphics are copyright © 2020 by the Environmental Mutagenesis and Genomics Society and may not be used or duplicated without written consent from the Society. 4 Table of Contents EMGS Sponsor List .........................................................................3 Title Page ........................................................................................4 How to Access EMGS 2020 ............................................................6 EMGS Leadership ........................................................................7-9 Welcome, General Information ......................................................10 Sponsor Recognition ................................................................12-13 Keynote Speakers ....................................................................14-15 Special Interest Groups & Committees at a Glance ......................16 EMGS Program Schedule ........................................................17-37 EMGS Posters ..........................................................................38-44 EMGS Annual Event Site On the Annual Meeting Event site you can view the abstracts for all sessions, build your agenda, see a list of attendees, and more. To access the event site, use the following links: EMGS Annual Meeting Site: https://www.emgs-us.org/p/cm/ld/fid=501 Accessing Live Virtual Sessions: Presenters and registered attendees will receive an email with an invitation to the EMGS 2020 Virtual Annual Meeting. This will enable all users to access our Virtual Annual Meeting page that will have links to all the meetings as well as showcase our poster presentations. (See the planned Program for a thor- ough overview of the meeting.) For other questions about the meeting, please contact the EMGS business office at [email protected] or call 904-289-3410. The Program for the 2020 Meeting may be updated throughout the meeting. To see the Program, go to https://www.emgs-us.org/p/cm/ld/fid=520 5 How To Access EMGS 2020 The Environmental Mutagenesis and Genomics Society’s Virtual Meeting kicks off September 12. Ev- ery presenter and registrant should be familiar with 3 KEY SITES for attending the meeting. Please read carefully and refer to this page as you prepare for and attend EMGS 2020. 3 KEY SITES 1) EMGS Website https://www.emgs-us.org/p/cm/ld/fid=501 This is the site for finding an overview of EMGS 2020 and its offerings including the official Program. https://www.emgs-us.org/p/cm/ld/fid=501 2) EMGS 2020 Official Event Site https://www.emgs-us.org/event/15/ Ready to plan your week? Start here. Registered attendees can browse scheduled programs and sessions, and review information about the presenters and abstracts. You can explore what is on the schedule, day by day, and then save specific presentations to a personalized agenda (to be found under your “My Profile” tab.) NOTE: This site requires a login, so have access to the email you used to register for the meeting. Your MEETING REGISTRATION CODE (which you can find in your regis- tration confirmation email) will serve as your password for your initial login.Y ou can update that later. 3) VIRTUAL SESSION SITE https://www.emgs2020conference.com This is where you will access live and recorded sessions scheduled for EMGS 2020. The Virtual An- nual Meeting Site — https://www.emgs2020conference.com/ — is now open and accessible to meet- ing registrants. This site is where you will access all of the meeting’s live and recorded content. Please take the opportunity to log on and explore the Virtual Annual Meeting Site prior to the Septem- ber 12 kickoff. Once you log on, you will have access to an agenda for each day of the meeting.As scheduled presentations begin, you will have the option of clicking a “Join Here” button that will link you to a corresponding Zoom session. For questions about the meeting, please contact the EMGS business office at [email protected] or call 904-289-3410. 6 EMGS Leadership EMGS Executive Board EMGS Council President: William Kaufmann, PhD Bret Freudenthal (2021) Vice President: Carol Yauk, PhD Brian Chorley, PhD (2021) Treasurer: Christi A. Walter, PhD Caren Weinhouse, PhD (2021) Secretary: Janice M. Pluth, PhD Carol Swartz, PhD (2020) Past President: Miriam C. Poirier Chris Farabaugh, PhD (2020) Council Representative: Les Hanakahi Jill Escher, PhD (2022) Council Representative: Christopher Faulk Jackie Goodrich, PhD (2021) Chris Faulk, PhD (2022) Joel N. Meyer, PhD (2020) Les Hanakahi, PhD (2022) Nan Mei, PhD (2020) Natalie Gassman, PhD (2021) Robert Heflich, PhD (2022) Patricia L. Opresko, PhD (2020) Isabelle R. Miousse, PhD (2022) EMGS Past Presidents Alexander Hollaender, PhD (1970) R. Julian Preston, PhD (1989) Peter J. Stambrook, PhD (2005) Ernst Freese, PhD (1972) George R. Hoffmann, PhD (1990) Martina L. Veigl, PhD (2006) Frederick J. de Serres, PhD (1974) Michael D. Waters, PhD (1991) Andrew J. Wyrobek, PhD (2007) Jan Drake, PhD (1976) James T. MacGregor, PhD, DABT (1992) Priscilla K. Cooper, PhD (2008) Seymour Abrahamson, PhD (1977) Philip C. Hanawalt, PhD (1993) Michael J. Plewa, PhD (2009) David J. Brusick, PhD, ATS (1978) James M. Gentile, PhD (1994) Jeffrey L. Schwartz, PhD (2010) Mortimer L. Mendelsohn, MD, PhD (1979) Raymond R. Tice, PhD (1995) Catherine B. Klein, PhD (2011) Sheldon Wolff, PhD (1980) Raymond W. Tennant, PhD (1996) Mats Ljungman, PhD (2012) Verne A. Ray, PhD (1981) Sid Aaron, PhD, DABT (1997) Ofelia A. Olivero, PhD, ATS (2013) Gordon W. Newell, PhD (1982) Rosalie K. Elespuru, PhD (1998) Suzanne M. Morris, PhD (2014) Richard J. Albertini, MD, PhD (1983) James S. Felton, PhD (1999) Bevin P. Engelward, ScD (2015) Liane B. Russell, PhD (1984) James D. Tucker, PhD (2000) Thomas E. Wilson, MD, PhD (2016) Michael D. Shelby, PhD (1985) David M. DeMarini, PhD (2001) Robert W. Sobol, PhD (2017) John A. Heddle, PhD (1986) Lawrence A. Loeb, MD, PhD (2002) Miriam C. Poirier, PhD (2018) Anthony V. Carrano, PhD (1987) David A. Eastmond, PhD (2003) William Kaufmann, PhD (2019) Sheila M. Galloway, PhD (1988) Leona D. Samson, PhD (2004) EMGS Staff Robert Bevans-Kerr, Executive Director Janece Bevans-Kerr, Director of Member Services Nathan Bevans-Kerr, Executive Assistant Diana Kerr, Executive Assistant Craig Richardson, Assistant Manager Channah Pool, Executive Assistant 7 EMGS Committees Alexander Hollaender Outreach Finance and Fundraising Patricia A. Escobar, PhD, Chair Barbara S. Shane, PhD, DABT, Chair Emilio Rojas, PhD, Co-Chair Laura L. Custer, PhD, Treasurer Brian N Chorley, PhD, Council Liaison Robert A. Bevans-Kerr, Executive Director Graciela Spivak, PhD, Past Chair Patricia L. Opresko, PhD, Council Liaison Priscilla K. Cooper, PhD Malathi Banda, PhD Philip C. Hanawalt, PhD Thomas W. Glover, PhD Mats Ljungman, PhD Guo-Min Li Patricia Ramos-Morales, DSc Jeffrey L. Schwartz, PhD Javier Revollo, PhD Robert W. Sobol Hilde E. van Gijssel, PhD Robert R. Young, MS Paul A. White, PhD Luoping Zhang, PhD Membership Professional Development Stephanie L. Smith-Roe, PhD, Chair Awards & Honors Malathi Banda, PhD, Co-Chair Michael George Kemp, PhD, Chair Nan Mei, PhD, Council Liaison Nan Mei, PhD, Co-Chair Julie Cox Isabelle R. Miousse, PhD, Board Liaison Hilde E. van Gijssel, PhD William M. Baird, PhD Xiaoqing Guo Nikolai
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  • PDS5B Regulates Cell Proliferation and Motility Via Upregulation of Ptch2 In

    PDS5B Regulates Cell Proliferation and Motility Via Upregulation of Ptch2 In

    Cancer Letters 460 (2019) 65–74 Contents lists available at ScienceDirect Cancer Letters journal homepage: www.elsevier.com/locate/canlet Original Articles PDS5B regulates cell proliferation and motility via upregulation of Ptch2 in T pancreatic cancer cells ∗∗ ∗ Jia Maa, ,1, Yue Cuib,1, Tong Caoc, Hui Xud, Ying Shia, Jun Xiaa, Yisheng Taoe, Z. Peter Wanga,f, a Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Anhui, 233030, China b Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui, China, 233030, China c Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233004, China d Department of Laboratory Medicine, Bengbu Medical College, Anhui, 233030, China e Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Anhui, China, 233030, China f Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 02115, MA, USA ARTICLE INFO ABSTRACT Keywords: Pds5b (precocious dissociation of sisters 5B) is involved in both tumorigenesis and cancer progression; however, Pds5b the functions and molecular mechanisms of Pds5b in pancreatic cancer (PC) are unknown. Several approaches Ptch2 were conducted to investigate the molecular basis of Pds5b-related PC progression, including transfection, MTT, Invasion FACS, western blotting, wound healing assay, transwell chamber invasion assay, and immunohistochemical Growth methods. Pds5b overexpression inhibited cell growth and induced apoptosis, whereas the inhibition of Pds5b Pancreatic cancer promoted growth of PC cells. Moreover, Pds5b overexpression inhibited cell migration and invasion, while the downregulation of Pds5b enhanced cell motility. Furthermore, reduced Pds5b expression was associated with survival in PC patients.
  • Why Is DNA Double Stranded? the Discovery of DNA Excision Repair Mechanisms

    Why Is DNA Double Stranded? the Discovery of DNA Excision Repair Mechanisms

    | PERSPECTIVES Why Is DNA Double Stranded? The Discovery of DNA Excision Repair Mechanisms Bernard S. Strauss1 Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637 ORCID ID: 0000-0001-7548-6461 (B.S.S.) ABSTRACT The persistence of hereditary traits over many generations testifies to the stability of the genetic material. Although the Watson–Crick structure for DNA provided a simple and elegant mechanism for replication, some elementary calculations implied that mistakes due to tautomeric shifts would introduce too many errors to permit this stability. It seemed evident that some additional mechanism(s) to correct such errors must be required. This essay traces the early development of our understanding of such mech- anisms. Their key feature is the cutting out of a section of the strand of DNA in which the errors or damage resided, and its replacement by a localized synthesis using the undamaged strand as a template. To the surprise of some of the founders of molecular biology, this understanding derives in large part from studies in radiation biology, a field then considered by many to be irrelevant to studies of gene structure and function. Furthermore, genetic studies suggesting mechanisms of mismatch correction were ignored for almost a decade by biochemists unacquainted or uneasy with the power of such analysis. The collective body of results shows that the double-stranded structure of DNA is critical not only for replication but also as a scaffold for the correction of errors and the removal of damage to DNA. As additional discoveries were made, it became clear that the mechanisms for the repair of damage were involved not only in maintaining the stability of the genetic material but also in a variety of biological phenomena for increasing diversity, from genetic recombination to the immune response.