(12) Patent Application Publication (10) Pub. No.: US 2014/0023690 A1 Fosco, JR
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Pseudo-Cholinesterase in Rat Erythrocytes Basis of Its Substrate Ratio, It Is Possible That It May Be a Butyro-Cholinesterase
No. 4535 September 29, 1956 NATURE 697 Pseudo-cholinesterase in Rat Erythrocytes basis of its substrate ratio, it is possible that it may be a butyro-cholinesterase. .ALTHOUGH there are many references in the literature to the existence of different types of cholin D.R. DAVIES esterase in mammalian sera1, it is generally believed J. P. RUTLAND 2 that human red cells contain only one type • Further more, we can find no evidence in the literature for Chemical Defence Experimental Establishment the existence of a pseudo-cholinesterase in any (Ministry of Supply), mammalian erythrocytes, although many workers Porton, Salisbury. have stated that benzoylcholine is hydrolysed by May 3. red cells. Since, however, the rate of hydrolysis is 1 Mundell, D. B., Nature, 153, 557 (1944). Ellis, S., Sanders, S., and slow, this breakdown of a substrate formerly presumed Bodansky, 0., J. Pharmacol., 91, 225 (1947). Levine M G and Suran, A. A., Enzymologia, 15, 17 (1951). ' · ., to be specific for pseudo-cholinesterase has been 'Mendell, B., Mundell, D. B., and Rudney, H., Biochem. J. 37 473 attributed to true cholinesterase. Indeed, Adams3 (1943). ' ' has shown that purified true cholinesterase does • Adams, D. H., Bwchim. Biophys. Acta, ~. 1 (1949). hydrolyse benzoylcholine, at a rate which would • Fraser, P. ~-, ti:,esis, University of Birmingham (1951), and private commumcat10n (1956). account for such observations. In spite of this, • Aldridge, W. N., Biochem. J., 53, 62 (1953). Austin, L., and Berry some results obtained by Fraser with benzoylcholine• W. K., Bwchem. J., 54, 695 (1953). ' imply the existence of more than one type of cholin 'Bayliss, B. -
Aldrich FT-IR Collection Edition I Library
Aldrich FT-IR Collection Edition I Library Library Listing – 10,505 spectra This library is the original FT-IR spectral collection from Aldrich. It includes a wide variety of pure chemical compounds found in the Aldrich Handbook of Fine Chemicals. The Aldrich Collection of FT-IR Spectra Edition I library contains spectra of 10,505 pure compounds and is a subset of the Aldrich Collection of FT-IR Spectra Edition II library. All spectra were acquired by Sigma-Aldrich Co. and were processed by Thermo Fisher Scientific. Eight smaller Aldrich Material Specific Sub-Libraries are also available. Aldrich FT-IR Collection Edition I Index Compound Name Index Compound Name 3515 ((1R)-(ENDO,ANTI))-(+)-3- 928 (+)-LIMONENE OXIDE, 97%, BROMOCAMPHOR-8- SULFONIC MIXTURE OF CIS AND TRANS ACID, AMMONIUM SALT 209 (+)-LONGIFOLENE, 98+% 1708 ((1R)-ENDO)-(+)-3- 2283 (+)-MURAMIC ACID HYDRATE, BROMOCAMPHOR, 98% 98% 3516 ((1S)-(ENDO,ANTI))-(-)-3- 2966 (+)-N,N'- BROMOCAMPHOR-8- SULFONIC DIALLYLTARTARDIAMIDE, 99+% ACID, AMMONIUM SALT 2976 (+)-N-ACETYLMURAMIC ACID, 644 ((1S)-ENDO)-(-)-BORNEOL, 99% 97% 9587 (+)-11ALPHA-HYDROXY-17ALPHA- 965 (+)-NOE-LACTOL DIMER, 99+% METHYLTESTOSTERONE 5127 (+)-P-BROMOTETRAMISOLE 9590 (+)-11ALPHA- OXALATE, 99% HYDROXYPROGESTERONE, 95% 661 (+)-P-MENTH-1-EN-9-OL, 97%, 9588 (+)-17-METHYLTESTOSTERONE, MIXTURE OF ISOMERS 99% 730 (+)-PERSEITOL 8681 (+)-2'-DEOXYURIDINE, 99+% 7913 (+)-PILOCARPINE 7591 (+)-2,3-O-ISOPROPYLIDENE-2,3- HYDROCHLORIDE, 99% DIHYDROXY- 1,4- 5844 (+)-RUTIN HYDRATE, 95% BIS(DIPHENYLPHOSPHINO)BUT 9571 (+)-STIGMASTANOL -
Classification Decisions Taken by the Harmonized System Committee from the 47Th to 60Th Sessions (2011
CLASSIFICATION DECISIONS TAKEN BY THE HARMONIZED SYSTEM COMMITTEE FROM THE 47TH TO 60TH SESSIONS (2011 - 2018) WORLD CUSTOMS ORGANIZATION Rue du Marché 30 B-1210 Brussels Belgium November 2011 Copyright © 2011 World Customs Organization. All rights reserved. Requests and inquiries concerning translation, reproduction and adaptation rights should be addressed to [email protected]. D/2011/0448/25 The following list contains the classification decisions (other than those subject to a reservation) taken by the Harmonized System Committee ( 47th Session – March 2011) on specific products, together with their related Harmonized System code numbers and, in certain cases, the classification rationale. Advice Parties seeking to import or export merchandise covered by a decision are advised to verify the implementation of the decision by the importing or exporting country, as the case may be. HS codes Classification No Product description Classification considered rationale 1. Preparation, in the form of a powder, consisting of 92 % sugar, 6 % 2106.90 GRIs 1 and 6 black currant powder, anticaking agent, citric acid and black currant flavouring, put up for retail sale in 32-gram sachets, intended to be consumed as a beverage after mixing with hot water. 2. Vanutide cridificar (INN List 100). 3002.20 3. Certain INN products. Chapters 28, 29 (See “INN List 101” at the end of this publication.) and 30 4. Certain INN products. Chapters 13, 29 (See “INN List 102” at the end of this publication.) and 30 5. Certain INN products. Chapters 28, 29, (See “INN List 103” at the end of this publication.) 30, 35 and 39 6. Re-classification of INN products. -
4 Supplementary File
Supplemental Material for High-throughput screening discovers anti-fibrotic properties of Haloperidol by hindering myofibroblast activation Michael Rehman1, Simone Vodret1, Luca Braga2, Corrado Guarnaccia3, Fulvio Celsi4, Giulia Rossetti5, Valentina Martinelli2, Tiziana Battini1, Carlin Long2, Kristina Vukusic1, Tea Kocijan1, Chiara Collesi2,6, Nadja Ring1, Natasa Skoko3, Mauro Giacca2,6, Giannino Del Sal7,8, Marco Confalonieri6, Marcello Raspa9, Alessandro Marcello10, Michael P. Myers11, Sergio Crovella3, Paolo Carloni5, Serena Zacchigna1,6 1Cardiovascular Biology, 2Molecular Medicine, 3Biotechnology Development, 10Molecular Virology, and 11Protein Networks Laboratories, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano, 34149, Trieste, Italy 4Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy 5Computational Biomedicine Section, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, 52425, Jülich, Germany 6Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy 7National Laboratory CIB, Area Science Park Padriciano, Trieste, 34149, Italy 8Department of Life Sciences, University of Trieste, Trieste, 34127, Italy 9Consiglio Nazionale delle Ricerche (IBCN), CNR-Campus International Development (EMMA- INFRAFRONTIER-IMPC), Rome, Italy This PDF file includes: Supplementary Methods Supplementary References Supplementary Figures with legends 1 – 18 Supplementary Tables with legends 1 – 5 Supplementary Movie legends 1, 2 Supplementary Methods Cell culture Primary murine fibroblasts were isolated from skin, lung, kidney and hearts of adult CD1, C57BL/6 or aSMA-RFP/COLL-EGFP mice (1) by mechanical and enzymatic tissue digestion. Briefly, tissue was chopped in small chunks that were digested using a mixture of enzymes (Miltenyi Biotec, 130- 098-305) for 1 hour at 37°C with mechanical dissociation followed by filtration through a 70 µm cell strainer and centrifugation. -
Wo 2010/075090 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 1 July 2010 (01.07.2010) WO 2010/075090 A2 (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 409/14 (2006.01) A61K 31/7028 (2006.01) kind of national protection available): AE, AG, AL, AM, C07D 409/12 (2006.01) A61P 11/06 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2009/068073 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 15 December 2009 (15.12.2009) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, (26) Publication Language: English TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 61/122,478 15 December 2008 (15.12.2008) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (71) Applicant (for all designated States except US): AUS- ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, PEX PHARMACEUTICALS, INC. -
PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. -
WHO Drug Information
WHO DRUG INFORMATION VOLUME 8 - N U M B E R 3 1994 RECOMMENDED INN LIST 34 INTERNATIONAL NONPROPRIETARY N A M E S F O R P H A R M A C E U T I C A L SUBSTANCES WORLD HEALTH ORGANIZATION • GENEVA Volume 8, Number 3, 1994 World Health Organization, Geneva WHO Drug Information Contents General Policy Topics Regulatory Matters Ethics and drug promotion: the CIOMS Large-scale HIV vaccine trials deferred 152 consensus 123 Antidepressants and hyponatraemia 152 Azapropazone and photosensitivity 153 Personal Perspectives Blood: safeguards to prevent Revision of the IFPMA code of pharmaceutical transmission of pathogens 153 Bromocriptine: no longer recommended to marketing practices 125 suppress lactation 153 Counterfeit medicines: a growing concern 154 Update on AIDS Felbamate and aplastic anaemia 154 HIV vaccines: advances and setbacks 128 Neuroleptic sensitivity in dementia 155 Zidovudine: redressment of early expectations 130 Nonsteroidal anti-inflammatory drugs: Zidovudine: renewed encouragement 131 relative safety 155 China to work with the European Reports on Individual Drugs Pharmacopoeia Commission 156 Antiarrhythmic agents: more concerns over Move to ban distribution of drug samples 156 risks and benefits 134 Theophylline potentiated by fluvoxamine 156 Oral contraceptives: no apparent association Tiaprofenic acid and severe cystitis 156 with diabetic complications 135 Zidovudine approved to prevent HIV Oral contraceptive use and protection against transmission in pregnancy 157 ovarian cancer 136 Ethical criteria for medicinal drug promotion -
1-Pyrene-Butyrylcholine: a Fluorescent Probe for the Cholinergic
Proc. Nat. Acad. Sci. USA Vol. 72, No. 8, pp. 3097-3101, August 1975 Biophysics 1-Pyrene-butyrylcholine: A fluorescent probe for the cholinergic system (long-lifetime fluorescent probe/neuromuscular junction/acetylcholine receptor/visualization of synapse) F. J. BARRANTES, B. SAKMANN, R. BONNER, H. EIBL, AND T. M. JOVIN Departments of Molecular Biology, Neurobiology, and Biochemical Kinetics, Max-Planck-Institut fur Biophysikalische Chemie, D-3400 Gottingen-Nikolausberg, West Germany Communicated by Manfred Eigen, May 19,1975 ABSTRACT The action of I-pyrene-butyrylcholine, a probes having intrinsically long excited-state lifetimes along new cholinergic fluorescent probe, as been studied at the with a high sensitivity to environmental factors. With this in cellular level using electrophysiological and fluorescence mind, 1-pyrene-butyrylcholine (PBC) was synthesized, and techniques. The spectroscopic properties of the probe were its action studied at the cellular level under physiological found to be similar to those of pyrene-butyric acid, the ex- cited-state lifetime in air-saturated aqueous solutions being conditions. 92 nsec. At micromolar concentrations the probe was found The fluorescent probe behaves as a nondepolarizing, re- to exert a nondepolarizing, reversible blocking action at the versible blocking agent in a nicotinic synapse, it specifically neuromuscular junction of the frog. The same cholinolytic ef- labels the neuromuscular junction, and it possesses a long ex- fect was observed in hypersensitive denervated muscles. cited-state lifetime. The curare-like cholinergic activity of The synaptic localization of the probe could be observed make it therefore ap- with fluorescence microscopy using sub- and micromolar PBC and its spectroscopic properties concentrations. -
Downloaded for Personal Non-Commercial Research Or Study, Without Prior Permission Or Charge
https://theses.gla.ac.uk/ Theses Digitisation: https://www.gla.ac.uk/myglasgow/research/enlighten/theses/digitisation/ This is a digitised version of the original print thesis. Copyright and moral rights for this work are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge This work cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given Enlighten: Theses https://theses.gla.ac.uk/ [email protected] STUDIES OU THE MODE OF ACTION OF QUATERNARY AMMONIUM COMPOUNDS WITH MUSCLE RELAXANT AND OTHER PHARMACOLOGICAL ACTIVITIES A Thesis submitted to the University of Glasgow in candidature for the degree of Doctor of Philosophy in the Faculty of Medicine *y Thomas C. Muir, B.Sc., M.P.S. Division of Experimental Pharmacology, Institute of Physiology, The University, Glasgow. March 1962. ProQuest Number: 10656287 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest ProQuest 10656287 Published by ProQuest LLC(2017). Copyright of the Dissertation is held by the Author. -
B Ramamohima R
I I CYTOPROTECTIVE ACTIONS PF NICOTINE: THE INCREASED EXPRESSION OF a.7 NICOTINIC RECEPTORS AND NGF/TrkA RECEPTORS ' . ' f !'b y' Ramamohima R. Jonnala ' ' ' I' Submitted to the Faculty o~the School of Graduate Studies of Medical College of Georgia in Partial Fulfillment of the Requirements of the Degree of Doctor of Philosophy Juiy, 2001 I' l Cytoprotective Actions of Nicotine: The Increased Expression of a.7 Nicotinic Receptors a-!ld NGF/TrkA Receptors This dissertation is submitted by Ramamohana R. Jonnala and has been examined and approved by an appointed committee of the faculty of the school of Graduate Studies of the Medical College of Georgia. The signatures which appear below verify the fact that all required changes have been incorporated and that the dissertation has received final approval with reference to content, form and accuracy of presentation. ' This dissertation is therefore in partial fulfillment of the requirements of the degree of Doctor of Philosophy. ACKNOWLEDGMENTS I would like to extend my appreciation to my major advisor, Dr. Jerry J. Buccafusco, for his guidance, encouragement and support. I would also like to thank my committee members, Dr. Alvin V. Terry Jr., Dr. William D. Hill, Dr. Nevin A. Lambert and Dr. Clare M. Bergson and also my thesis readers Dr. Debra Gearhart and Dr. Dale W. Sickles for their time and valuable suggestions. My sincere thanks to Dr. Deborah L. Lewis, Dr. Robert W. Caldwell and Dr. Gary C. Bond for encouraging me to enter the graduate program in the Department of Pharmacology & Toxicology, Medical College of Georgia. My sincere thanks to members of my laboratory Laura, Vanessa, Daniel, Cat, Mark, Nandu, Lu, and Shyamala for their assistance and suggestions. -
Pharma Times Pharmacist the ‘Apostrophe’ of the Health Profession
Single Copy Price ` 250 Vol. 52 No. 04 | April 2020 ISSN 0031-6849 Total Pages : 63 Indexed by Scopus & Embase Official Monthly Newsmagazine of Indian Pharmaceutical Association Listed in journals approved by UGC for CAS & Appointment of University Teachers Commitment to Public Health and Science will go a long way in Defeating ‘Pandemics’ ... 22 Pharmaceutical Sector of India, Perspectives & its Journey During Covid-19: Recent Problems & Strategic Solutions –PPP Mode .................................................15 Pharma Times Pharmacist the ‘Apostrophe’ of the Health profession ..... 20 Official Publication of: Covid-19: A Wake up Call for Pharma Stakeholders...........25 The Indian Pharmaceutical Association, Safety of Pharmaceutical Employees in Covid-19 Kalina, Santacruz (E), Mumbai 400098. Pandemic ........................................................................................26 Pharma Times - Vol. 52 - No. 04 - April 2020 PB Pharma Times -- Vol.Vol. 5252 -- No.No. 0304 -- MarchApril 2020 2020 2 44 Pharma Pharma Times Times - Vol.- Vol. 52 52 - No.- No. 03 04 - March- April 20202020 453 COL Pharma Times - Vol. 52 - No. 0403 - AprilMarch 2020 2020 2 2 Pharma Pharma Times Times - Vol.- Vol. 52 52 - No.- No. 03 04 - March- April 2020 3 Contents Novel Coronavirus Pandemic- Stark Realities & New Lessons for Science & Humanity: Dr. Jayant B Dave, Adjunct Professor, L M College of Pharmacy, Ahmedabad .................................................................................9 Pharmaceutical Sector of India, Perspectives -
Journal of Pharmacy and Pharmacology 1962 Volume.14 Suppl
BRITISH PHARMACEUTICAL CONFERENCE NINETY-NINTH ANNUAL MEETING, LIVERPOOL, 1962 REPORT OF PROCEEDINGS OFFICERS: President: Miss M. A. Bu rr, M.P.S., Nottingham Chairman: J. C. H anbury, M.A., B.Pharm., F.P.S., F.R.I.C. Vice-Chairmen: R. R . Bennett, B.Sc., F.P.S., F.R.I.C., Eastbourne. H . D eane, B.Sc., F.P.S., F.R.I.C., Sudbury. H . H umphreys Jones, F.P.S., F.R.I.C., Liverpool. T. E. W allis, D .S c., F.P.S., F.R.I.C., F.L.S., London. H . Brindle, M .Sc., F.P.S., F.R.I.C., Altrincham. N. Evers, B.Sc., Ph.D., F.R.I.C., Ware. A. D . P ow ell, M.P.S., F.R.I.C., Nottingham. H. Berry, B.Sc., Dip.Bact. (Lond.), F.P.S., F.R.I.C., Eastbourne. H . B. M ackie, B.Pharm., F.P.S., Brighton. G. R. Boyes, L.M.S.S.A., B.Sc., F.P.S., F.R.I.C., London. H . D avis, C.B.E., B.Sc., Ph.D., F.P.S., F.R.I.C., London. J. P. T o dd , Ph.D., F.P.S., F.R.I.C., Glasgow. K. Bullock, M .Sc., Ph.D., F.P.S., F.R.I.C., Manchester. F. H artley, B.Sc., Ph.D., F.P.S., F.R.I.C., London. G. E. F oster, B.Sc., Ph.D., F.R.I.C., Dartford. H . T reves Bro w n , B.Sc., F.P.S., London.