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DATASHEET USA: [email protected] FOR IN VITRO RESEARCH USE ONLY Europe: [email protected] NOT FOR USE IN HUMANS OR ANIMALS China: [email protected] GFPT1 Polyclonal Anbody Catalog number: 14132-1-AP Background Size: 43 μg/150 μl GFPT1 (glutamine-fructose-6-phosphate transaminase 1) catalyzes the transfer of an Source: Rabbit amino group from glutamine onto fructose-6-phosphate, yielding glucosamine-6- Isotype: IgG phosphate (GlcN-6-P) and glutamate. GFPT1 is the key enzyme of the hexosamine Synonyms: pathway and is required for crical events in neuromuscular transmission. GFPT1; GFA, GFAT, GFAT 1, Mutaons of GFPT1 cause congenital myasthenic syndromes (CMS). (21310273, GFAT1, GFAT1m, GFPT, GFPT1 25765662) Applications Tested applicaons: ELISA, IHC, IF, WB Cited applicaons: IF, WB Species specificity: Human,Mouse,Rat,Zebrafish; other species not tested. Cited species: Human Caculated GFPT1 MW: 681aa,77 kDa Immunofluorescent analysis of Observed GFPT1 MW: 77kd HepG2 cells, using GFPT1 anbody 14132-1-AP at 1:100 diluon and PE- Posive WB detected in Human skeletal muscle ssue, HepG2 cells labeled goat an-rabbit IgG(red). Posive IHC detected in Human gliomas ssue, human hepatocirrhosis ssue Blue pseudocolor = DAPI (fluorescent Posive IF detected in HepG2 cells DNA dye). Recommended diluon: WB: 1:200-1:2000 IHC: 1:20-1:200 IF: 1:20-1:200 Applicaon key: WB = Western blong, IHC = Immunohistochemistry, IF = Immunofluorescence, IP = Immunoprecipitaon Immunogen information Immunogen: Ag5312 Immunohistochemical of paraffin- GenBank accession number: BC045641 embedded human gliomas using Gene ID (NCBI): 2673 14132-1-AP(GFPT1 anbody) at Full name: Glutamine-fructose-6-phosphate transaminase 1 diluon of 1:100 (under 10x lens) Product information Purificaon method: Angen affinity purificaon Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Immunohistochemical of paraffin- embedded human gliomas using 14132-1-AP(GFPT1 anbody) at diluon of 1:100 (under 40x lens) human skeletal muscle ssue were subjected to SDS PAGE followed by western blot with followed by western blot with 14132-1-AP(GFPT1 anbody) at diluon of 1:500.

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High-Throughput Discovery of Novel Developmental Phenotypes
High-throughput discovery of novel developmental phenotypes The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Dickinson, M. E., A. M. Flenniken, X. Ji, L. Teboul, M. D. Wong, J. K. White, T. F. Meehan, et al. 2016. “High-throughput discovery of novel developmental phenotypes.” Nature 537 (7621): 508-514. doi:10.1038/nature19356. http://dx.doi.org/10.1038/nature19356. Published Version doi:10.1038/nature19356 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:32071918 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Nature. Manuscript Author Author manuscript; Manuscript Author available in PMC 2017 March 14. Published in final edited form as: Nature. 2016 September 22; 537(7621): 508–514. doi:10.1038/nature19356. High-throughput discovery of novel developmental phenotypes A full list of authors and affiliations appears at the end of the article. Abstract Approximately one third of all mammalian genes are essential for life. Phenotypes resulting from mouse knockouts of these genes have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5000 knockout mouse lines, we have identified 410 Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms #Corresponding author: [email protected].
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