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EMBL in Italy EMBL in Italy Thursday-Friday, 20-21 May 2021 EMBL in Italy: A Brave New World of RNA Virtual at the Italian Institute of Technology (IIT), Genoa PROGRAMME Thursday 20 May Join Zoom Welcome from the organisers: EMBL and IIT 30 mins 13:30–14:00 Host: Mehrnoosh Rayner 3-5 mins Head of Alumni Relations, EMBL Giorgio Metta Scientific Director, IIT, Genoa 5-7 mins Cornelius Gross Interim Head of EMBL Rome, Monterotondo 8-2 mins Stefano Gustincich Associate Director for Technologies for Life 8-2 Science (LifeTech), Director Central RNA Lab at IIT, Genoa mins 14:00–14:50 Session 1: Non-coding RNAs in Health and Disease 3-5 Host: Irene Bozzoni mins Professor, IIT & Sapienza University, Rome Ana Boskovic Group Leader, EMBL Rome 20+5 “Small RNAs-transferring information between generators” mins Gian Gaetano Tartaglia Group Leader, IIT 20+5 “Non-coding RNAs and phase separation rule the world” mins 14:50–15:00 Break 10 mins 15:00–15:30 Andrea Carfi VP and Head of Research, Infectious Disease at 20+10 Moderna, Boston mins 15:30–16:00 Keynote speaker 3 mins Host: Irene Bozzoni Professor, IIT & Sapienza University, Rome Adrian Krainer St. Giles Foundation Professor and CSHL 25+5 Cancer Center Deputy Director of Research, Cold Spring Harbor mins Laboratory “From Base Pairs to Bedside: Antisense Modulation of RNA Splicing” 16:00–16:15 7x Flash talks 1 min each Mara Maldotti Postdoc, University of Turin “The acetyltransferase p300 is recruited to enhancers by lncRNAs via triple helix formation” Michela A.Denti Associate Professor, University of Trento “A therapeutic approach for 4R tauopathies based on siRNAs switching Tau splicing isoforms” Sara Formichetti Ph.D Student, EMBL Rome “The role of O-GlcNAcylation in mammalian transcriptional regulation” Jacopo Manigrasso Ph.D Student, IIT “Functional Dynamics of Pre-mRNA Splicing Unveiled at Atomic Resolution” Eleonora Perego Postdoc, IIT “Fluorescence Fluctuation Spectroscopy with a SPAD array detector to unravel the dynamics of RNA in living cells” Carmela Rubolino Postdoc, IIT “Target-Directed miRNA degradation in breast cancer” Gloria Ferrari Bravo Ph.D. Student, University of Trieste “An evolutionarily conserved pathway dependent on the prolyl- isomerase PIN1 protects the genome” 16:15–16:50 Keynote speaker 3-5 Host: Roberto Di Lauro mins Professor Emeritus, University of Naples (EMBL Group Leader, 1986-1991, EMBL SAC Member, 2005- 2011) Iain Mattaj Director, Human Technopole, Milan 25+5 (EMBL Director General, 2005-2018) mins “How RNA got me to Human Technopole” Join Spatial Poster Session / Presentation of IIT/ Virtual Tours and Chat Networking with participants and speakers 16:50-18:00 PROGRAMME Friday 21 May Join Zoom Session 2: RNA in Disease Prevention and Therapy – part 1 10 mins 09:00–09:10 Host: Juergen Bauer Deputy Managing Director, EMBLEM, Heidelberg 09:10-09:35 Ennio De Gregorio Professor, Stanford University 20+5 Head of Research & Development Center, GSK Vaccines, Siena mins (EMBL Predoctoral Fellow, 1996-1999) “RNA vaccine platforms” 09:35-10:00 Lucia Faccio Partner, Sofinnova Partners, Milano 20+5 “Sofinnova Partners: two decades of investment in mins outstanding Italian science” 10:00–10:10 Break 10 mins Join Spatial Poster Session / Presentation of IIT/ Virtual Tours of EMBL Chat Core Facilities and Networking with participants and speakers 10:10–11:10 Join Zoom Session 2: RNA in Disease Prevention and Therapy – part 2 3 mins 11:10-11:35 Host: Juergen Bauer Deputy Managing Director, EMBLEM Patrick Baumhof VP Formulation & Delivery, Curevac, 20+5 Tübingen mins “mRNA based therapeutics: SARS-CoV-2 vaccine CVnCoV” 11:35-12:35 Panel discussion: RNA in Disease Prevention and Therapy 60 mins Moderator: Alfredo Nicosia Professor, University of Naples (EMBL Postdoc, 1986-1990, Heidelberg) • Irene Bozzoni IIT & Sapienza University, Rome • Ennio De Gregorio GSK Vaccines, Siena • Juergen Bauer EMBLEM, Heidelberg • Stefano Gustincich IIT, Genova • Christian Jung Dementia Discovery Fund, London • Patrick Baumhof Curevac, Tübingen 12:35–12:50 Concluding Remarks 14 mins Stefano Gustincich, IIT Cornelius Gross, EMBL Rome EMBL, the European Molecular Biology Laboratory, drives visionary fundamental research and technology development in the life sciences. The institute works to transfer this knowledge for the benefit of society. EMBL offers services to the scientific community, trains the next generation of scientists, and strives to integrate the life sciences across Europe. EMBL is international, innovative, and interdisciplinary. Its more than 1700 staff, from over 80 countries, operate across six sites in Barcelona (Spain), Grenoble (France), Hamburg (Germany), Heidelberg (Germany), Hinxton (UK), and Rome (Italy). EMBL was established in 1974 as an intergovernmental organisation and is supported by over 20 member states. Istituto Italiano di Tecnologia (IIT -Italian Institute of Technology) is a scientific research center established in 2003 by the Italian Ministry of Education, University and Research and the Ministry of Economy and Finance, in order to promote excellence in both basic and applied research and to facilitate economic development at the national level. IIT scientific activities started in 2006, they are multidisciplinary with a very strong approach to technology transfer. Thre are 1800 IIT staff from 50 countries. Research is carried out in the Central Research laboratory in Genoa (IIT headquarters), in 11 research satellite centers across Italy and in 2 outstations in US. Co-organisers: Cornelius Gross, Stefano Gustincich [email protected] *Links to Zoom and Spatial Chat have been sent to all registered speakers and participants. If you cannot find yours, please contact “[email protected]” with the subject head: “Link to EMBL in Italy 2021”..
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