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Programme Book PROGRAMME BOOK The Convergence of Two Major Meetings Joint Conference of HGM 2013 and 21st International Congress of Genetics OF GLOBAL HEALTH AND SUSTAINABILITY 13 - 18 April 2013 The Sands Expo and Convention Center, Marina Bay Sands Host Joint Conference Partner www.hgm2013-icg.org 1 Contents Welcome Messages 3 Organising Committee 4 Conference Information 5 Programmes 9 Workshops 23 Speakers’ Index 24 Speakers’ Bio / Photo 32 Oral Presentation Schedule 66 Poster Presentation Schedule 71 Exhibition Floorplan 92 Exhibitor’s Listing 93 Sponsors & Exhibitions Profi le 94 Acknowledgements 100 2 Welcome Messages I wish to welcome all delegates of the HGM 2013 / 21st International Congress of Genet- ics to Singapore. This joint event by the Human Genome Organisation (HUGO) and the International Genetics Federation (IGF) will explore two of the most important topics in the 21st century: Genetics and Genomics of Global Health and Sustainability. To that end, our conference will examine the interface between the health of individuals with the health of the planet. The research topics that we will address include the genetics and genomics of human diseases, food crop and livestock improvement, ecological genomics, advanced genomic technologies, government policy and the management of a genome centred bioeconomy. It will be an intellectually broad and exciting event at which ideas and researchers from around the world interact. I would encourage delegates to use the HGM 2013 / 21st ICG conference as a meeting place to assemble their academic interest-groups for global deliberations and hope you will have an exciting time in this vibrant and cosmopolitan city of Singapore. Finally, I want to inform all delegates that HGM 2014 will be held in the scenic mountain lake city of Geneva, Switzerland, and the theme of the meeting: Genome Variation and Human Health. We will be tackling the anticipated challenges faced by the spectacular advances in the rapid analysis of individual genome sequenced. Edison Liu President, Human Genome Organisation Dear delegates of the HGM 2013 / 21st International Congress of Genetics, as president of the International Genetics Federation (IGF) I would like to welcome you all very heartily to Singapore. The International Congress of Genetics (ICG) has been held approximately every fi ve years, ever since its fi rst congregation in London, 1899. We are very happy to present you the 21st ICG as a joint event with HGM 2013, organised by our colleagues from HUGO. Science is a truly international endeavour. Over the course of 115 years, the twenty-one ICGs have been held in 14 different countries; today we meet in Singapore, for the fi rst time in Southeast Asia. We chose ”Genetics and Genomics of Global Health and Sustainability“ as the frame of our presentations and discussions. This topic emphasizes the fundamental genetic basis of all aspects of life on our planet. At the same time, it highlights the breath taking perspective and powerful insights into this genetic basis generated by the broad and rapidly advancing molecular studies of complete genomes. We trust that this knowledge shall endow mankind with the means to help sustain healthy life on earth. Toward that aim, all colleagues from the International Genetics Federation wish you a fruit- ful and inspiring congress here in Singapore. Alfred Nordheim President, International Genetics Federation 3 Organising Committee Local Organising Committee of HGM 2013 Prof Mohan Balasubramanian A/Prof Yijun Ruan Temasek Lifesciences Laboratory, Singapore Genome Institute of Singapore, Singapore National University of Singapore, Singapore Genome Technology, Singapore Genome Technology & Biology, Singapore Prof Kee-Seng Chia National University of Singapore, Singapore NUS-GIS Centre for Molecular Epidemiology National University of Singapore, Singapore A/Prof E-Shyong Tai National University of Singapore, Singapore Prof Neil Clarke National University Hospital, Singapore Genome Institute of Singapore, Singapore A/Prof Eng-King Tan Prof Stephen M. Cohen Singapore General Hospital, National Neuroscience Institute Institute of Molecular and Cell Biology, A*STAR, Singapore Duke-NUS Graduate Medical School, Singapore IMCB Workshop “Chemical Biology”, Singapore Ludwig Institute for Cancer Research, United Kingdom A/Prof Patrick Tan Genome Institute of Singapore, Singapore Prof Frank Eisenhaber Duke-NUS Graduate Medical School, Singapore Bioinformatics Institute, A*STAR, Singapore Institute of Genome Sciences and Policy, Duke University Cancer Science Institute of Singapore Prof Edison Liu National Cancer Centre, Singapore Human Genome Organisation (HUGO), Singapore National University of Singapore, Singapore Defence Medical & Environmental Research Institute, A/Prof Jianjun Liu DSO, Singapore Genome Institute of Singapore, Singapore Anhui Medical University, China A/Prof Yik-Ying Teo National University of Singapore, Singapore Prof Paul Matsudaira Life Sciences Institute Department of Biological Science, NUS Genome Institute of SIngapore NUS Centre of BioImaging Sciences, Singapore Prof Tien-Yin Wong A/Prof Niranjan Nagarajan National University of Singapore, Singapore Genome Institute of Singapore, Singapore National University Hospital, Singapore National University of Singapore, Singapore Singapore National Eye Centre, Singapore Prof Ivy Ng A/Prof Eric Yap KK Women’s & Children’s Hospital, Singapore Defence Medical & Environmental Research Institute Singapore Health Services, Singapore (DSO), Singapore International Programme Committee of 21st ICG Prof Philip Batterham Prof Bin Han The University of Melbourne, Australia National Centre for Gene Research, CAS, China Shanghai Institute for Biological Sciences, CAS, China Prof Welcome Bender (Co-Chair) Beijing Institute of Genomics, CAS, China Harvard Medical School, USA Prof Charles H. Langley Prof Pascale Cossart University of California, USA Pasteur Institute of Paris, France Prof Alfred Nordheim Prof Peter Donnelly University of Tuebingen, Germany Wellcome Trust Centre for Human Genetics University of Oxford, United Kingdom Prof David C. Page Whitehead Institute Prof Gerald R. Fink Massachusetts Institute of Technology Whitehead Institute Howard Hughes Medical Institute, USA Massachusetts Institute of Technology, USA Prof Detlef Weigel (Co-Chair) Max Planck Institute for Developmental Biology, Tübingen, Germany 4 Conference Information: Destination Map 5 Conference Information Conference Venue Emergency Numbers Venue In case of emergencies, dial 999 for Police, 995 for Ambulance and Fire Brigade. The Sands Expo and Convention Center, Marina Bay Sands, 10 Bayfront Avenue, Singapore 018956 Time Difference Getting to the Conference Venue Singapore’s time is 8 hours ahead of the Greenwich Mean Time (GMT). By bus: Bus services 97/97E, 106, 133, 502/502A, 518/518A. Weather & Attire By car: Car park entrances are located at Sands Expo and Singapore is generally warm and fairly humid. The average Convention Centre, via the Bayfront Avenue and Bayfront daytime temperature is 31°C (88°F), dropping to around Link. The North entrance is located along Bayfront Avenue; 24°C (75°F) in the evenings. Do expect occasional show- and the South entrance is along Bayfront Link. Please note ers and heavy rainfall. Light and comfortable clothing is that motorcycle parking is not available. best for everyday wear, however do bring along a jacket or By Mass Rapid Transit (MRT): Nearest MRT Station and shawl to the conference as the venue is air-conditioned. Exit: Bayfront MRT Station, Exits D (Circle Line). Please check that the particular train is heading to Bayfront MRT Public Transport before boarding. If the train ends at Promenade station, Public transport is highly accessible and inexpensive in you will need to transfer to the next train heading towards Singapore. The following modes of travel are available: Bayfront MRT. Buses: A fl eet of more than 3,500 fully air-conditioned By taxi: Taxis may access Bayfront Avenue via Raffl es Boule- buses operate daily from 0530 to 2300. Fares for the vard or Marina Boulevard (ERP charges apply). A surcharge buses are as low as SGD1-2, depending on the number of of S$3 is imposed for taxis leaving Marina Bay Sands. fare stages travelled. Mass Rapid Transit (MRT): The air-conditioned passenger Around the Conference Venue train service has stations all over the cty. Trains operate Restaurants & Retail from 0600 to 2330 at frequencies of 3-8 minutes (peak The Shoppes at Marina Bay Sands is one of Singapore’s hours) and 10-15 minutes (off-peak hours). Travel fares by largest luxury shopping malls with a refreshing mix of MRT range from SGD1 onwards. international brands, emerging labels and new concepts. Taxis: Taxis can be fl agged down 24 hours a day on most roads. Well-marked taxi stands are available outside most Besides astounding retail indulgence, The Shoppes at shopping centres and hotels. Current rates/ applicable sur- Marina Bay Sands includes a mix of gourmet restaurants charges are obtainable at tourist information counters and and bistros. at the hotel concierge. Visitor Information Money Matters Singapore Dollar (SGD) is Singapore’s currency. Money chang- ing services and Automated Teller Machines (ATMs) can be found at the Singapore Changi Airport, most shopping centres and hotels around the island. Credit cards such as Visa, MasterCard and American Express are commonly accepted in restaurants and shops. Electricity Singapore’s electrical voltage is 220-240 AC, 50 Hertz. A three-pin, square
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