According to Regulation (EU) No. 1907/2006 (REACH), Annex II (COMMISSION REGULATION (EU) No 453/2010)

Version: 1.0/EN Revision date: 28/05/2012 Product name: Mono bromobenzene

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier Product name: Mono bromobenzene Synonyms: Bromobenzene; Phenyl bromide; Bromobenzol REACH Reg. No.: No registration number is given. CAS No.: 108-86-1

1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Use as an intermediate in the Pharmaceutical and other fine chemical industries. Uses advised against: No information available.

1.3 Details of the supplier of the SDS

1.4 Emergency telephone number

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008[CLP] Flammable liquids, Category 3; H226 Skin irritation, Category 2; H315 Chronic aquatic toxicity, Category 2, H411

Classification according to Directive 67/548/EEC[DSD] or Directive 1999/45/EC[DPD] R10

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Xi; R38 N; R51-53

Additional information Full text of R-phrase(s)/H-statement(s): see SECTION 16.

2.2 Label elements Labelling according to Regulation (EC) No 1272/2008[CLP] Hazard pictogram(s):

Signal word: Warning Hazard statement(s): H226: Flammable liquid and vapour. H315: Causes skin irritation. H411: Toxic to aquatic life with long lasting effects. Precautionary statement(s): Prevention: P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. Response: P303 + P361 + P353 IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370 + P378: In case of fire: Use water spray, carbon dioxide (CO2), dry chemical alcohol-resistant foam for extinction. Disposal: P501: Dispose of contents/container in accordance with local/regional/national/international regulations. Supplemental Hazard information (EUH): No information available. Special rules for supplemental label elements for certain mixtures: No information available.

2.3 Other hazards No information available.

SECTION 3: Composition/information on ingredients

3.1 Substance/Preparation information Substance name: Mono Bromobenzene Index number: 602-060-00-9

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CAS No.: 108-86-1 EC No.: 203-623-8 Purity: 99.0 % min. The rest unspecified ingredients are impurities which do not contribute to the classification of the substance.

SECTION 4: First aid measures

4.1 Description of first aid measures General notes: In all cases of doubt, or when symptoms persist, seek medical attention.

Following inhalation: Remove from exposure, lie down. Move to fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Immediate medical attention is required.

Following skin contact: Wash off immediately with soap and plenty of water removing all contaminated clothes and shoes immediate medical attention is required.

Following eye contact: Immediate medical attention is required. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

Following ingestion: Never give anything by mouth to an unconscious person. Drink plenty of water. Get medical attention. If possible drink milk afterwards.

4.2 Most important symptoms and effects, both acute and delayed Acute: Irritation to the skin and eyes, probably also the respiratory tract, narcotic effects and effects on the liver at high exposure. Chronic: No information available for humans, toxic effects on the liver and kidneys found in animal experiments.

4.3 Indication of the immediate medical attention and special treatment needed No information available.

SECTION 5: Fire-fighting measures

5.1 Extinguishing media

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Suitable extinguishing media: Water spray. Carbon dioxide (CO2). Dry chemical alcohol-resistant foam. Use water spray to cool unopened containers. Unsuitable extinguishing media: No information available.

5.2 Special hazards arising from the substance or mixture Flammable/Explosive properties. Vapors may travel to source of ignition and flash back. Containers may explode when heated.

5.3 Advice for fire-fighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Refer to SECTION 8 for personal protective equipment. Prevention of skin and eye contact. Ensure adequate ventilation. Remove all sources of ignition Take precautionary measures against static discharges.

6.2 Environmental precautions Do not discharge into drains/surface waters/groundwater.

6.3 Methods and material for containment and cleaning up Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Keep in suitable and closed containers for disposal. Remove all sources of ignition. Use spark proof tools and explosion-proof equipment. Do not let this chemical enter the environment

6.4 Reference to other SECTIONs See SECTION 7 for information on safe handling. See SECTION 8 for information on personal protection equipment. See SECTION 13 for information on disposal.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Handle in accordance with good industrial hygiene and safety practice. Use personal protective equipment as required. Use only under a chemical fume hood. Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Avoid ingestion and inhalation. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use explosion-proof equipment. Take precautionary measures against static discharges.

7.2 Conditions for safe storage, including any incompatibilities

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Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition.

7.3 Specific end use(s) Apart from the uses mentioned in SECTION 1.2 no other specific uses are stipulated.

SECTION 8 : Exposure controls/personal protection

8.1 Control parameters Occupational exposure limit values: Not established.

DNEL (Derived No Effect Level) for workers and the general population: Not available.

PNEC (Predicted No Effect Concentration) values: Not available.

8.2 Exposure controls Appropriate engineering controls: Provide local exhaust or process enclosure ventilation system.

Personal protective equipment: Eye and face protection: Wear protective eye/face protection. Skin protection: Wear protective gloves/clothing to prevent contact. Respiratory protection: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Environmental exposure controls: Do not empty into drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties Appearance: Clear liquid Odour: aromatic pH: No information available.

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Melting point: -31°C / -23.8°F Boiling point: 156°C / 312.8°F Flash point: 51°C / 123.8°F(Closed cup) Evaporation rate: No information available. Flammability (solid, gas): Flammable. Upper/lower flammability or explosive limits: Lower: 0.5% Upper: 2.5% Vapour pressure: 13 hPa at 40°C 4 hPa at 20°C Density: 1.490 g/cm3 Solubility(ies): Practically insoluble Partition coefficient: n-octanol/water: Log Pow=2.99 Auto-ignition temperature: 565 °C Decomposition temperature: No information available. Viscosity: No information available. Explosive properties: No information available. Oxidising properties: No information available.

9.2 Other information No data available.

SECTION 10: Stability and reactivity

10.1 Reactivity Vapour/air-mixtures are explosive at intense warming.

10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature).

10.3 Possibility of hazardous reactions The substance can react dangerously with: Oxidizing agents, alkali/alkaline earth metals, peroxy compounds.

10.4 Conditions to avoid Keep away from open flames, hot surfaces and sources of ignition, Excess heat, and Incompatible products.

10.5 Incompatible materials Strong oxidizing agents. Alkali/alkaline earth metals. Peroxy compounds.

10.6 Hazardous decomposition products

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Carbon monoxide (CO). Carbon dioxide (CO2). Bromine.

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity Oral, LD50 : 2383 mg/kg (rat);

Inhalation, LC50: 20.411 mg/L

Dermal, LD50: No data available.

Skin corrosion/irritation: Causes skin irritation.

Serious eye damage/irritation: Slight irritation.

Respiratory or skin sensitization: The substance or mixture is not classified as respiratory or skin sensitization.

Germ cell mutagenicity: It was not mutagenic in the Ames test and did not cause any cytogenetic effects. The results of the micronucleus test on mice were positive and intraperitoneal application led to DNA and RNA adducts.

Carcinogenicity: No substance-specific information is available.

Reproductive toxicity: The substance-specific information is insufficient.

STOT-single exposure: The substance or mixture is not classified as specific target organ toxicant, single exposure.

STOT-repeated exposure: The substance or mixture is not classified as specific target organ toxicant, repeated exposure.

Aspiration hazard: No aspiration toxicity classification.

SECTION 12: Ecological information

12.1 Toxicity

Ecotoxicity Fish, LC50: 5.6 mg/L/96h(fathead minnow);

Crustacea, EC50: 1.6 mg/L/24h(Daphnia magna)

Algae, IC50: No data available.

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12.2 Persistence and degradability Biodegradability Result: Not readily biodegradable. 0 % Exposure time: 28 d (HSDB)

12.3 Bioaccumulative potential Bioaccumulation is not expected (Log Kow < 3).

12.4 Mobility in soil No information available.

12.5 Results of PBT and vPvB assessment PBT/vPvB assessment information is not available as chemical safety assessment not conducted.

12.6 Other adverse effects Henry constant 250 Pa*m3/mol

SECTION 13: Disposal considerations

13.1 Waste treatment methods Disposal must be made according to local and national regulations. Empty containers should be taken for local recycling, recovery or waste disposal.

SECTION 14: Transport information

14.1 Land transport (ADR) Proper Shipping Name: BROMOBENZENE Class: 3 UN-No.: 2514 Packing group: III Mark/Label: 3

14.2 Sea transport (IMDG) Proper Shipping Name: BROMOBENZENE

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Class: 3 UN-No.: 2514 Packing group: III Marine pollutant: Yes

14.3 Air transport (IATA) Proper Shipping Name: BROMOBENZENE Class: 3 UN-No.: 2514 Packing group: III

14.4 Additional information Mark/Label(s) for transport:

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture EU regulation: Authorisations: No information available. Restrictions on use: No information available. EINECS: CAS# 108-86-1 is listed in. DSD (67/548/EEC): CAS# 108-86-1 is listed in.

Other chemical regulation: USA Canada Australia Korea Japan China CAS No. TSCA DSL AICS ECL ENCS IECSC 108-86-1 Listed Listed Listed Listed Listed Listed

15.2 Chemical Safety Assessment No Chemical Safety Assessment has been carried out for this product.

SECTION 16: Other information

16.1 Revision Information Date of the previous revision: Not applicable. Date of this revision: 28/05/2012.

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Revision summary: The first new SDS

16.2 Abbreviations and acronyms CLP: EU regulation (EC) No 1272/2008 on classification, labelling and packaging of chemical substances and mixtures. CAS: Chemical Abstracts Service (division of the American Chemical Society). EINECS: European Inventory of Existing Commercial Chemical Substances. DSD: Dangerous Substance Directive (67/548/EEC). TSCA: Toxic Substances Control Act, The American chemical inventory. DSL: Domestic Substances List, The Canadian chemical inventory. AICS: The Australian Inventory of Chemical Substances. ECL: Existing Chemicals List, the Korean chemical inventory. ENCS: Japanese Existing and New Chemical Substances. IECSC: Inventory of existing chemical substances in China.

16.3 Key literature references and sources for data ESIS: European chemical Substances Information System. NLM: U.S. National Library of Medicine. GESTIS-database: Information system on hazardous substances of the German Social Accident Insurance. ICSC: International Chemical Safety Cards. HSDB: Hazardous Substances Data Bank. The Chemical Database: The Department of Chemistry of the University of Akron. Provided by company.

16.4 Relevant R-phrases/H-statements R10: Flammable. R38: Irritating to skin. R51-53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

16.5 Training advice Provide adequate information, instruction and training for operators.

16.6 Declare to reader The information in this SDS is provided all the relevant data fully and truly. However, the information is provided without any warranty on their absolute extensiveness and accuracy. This SDS was prepared to provide safety preventive measures for the users who have got professional training. The personal user who obtained this SDS should make independent judgment for the applicability of this SDS under special conditions. In these special cases, we do not assume responsibility for the damage. According to REACH Article 31(5), the SDS shall be supplied in an official language of the Member State(s) where the substance or mixture is placed on the market, unless the recipient

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According to Regulation (EU) No. 1907/2006 (REACH), Annex II (COMMISSION REGULATION (EU) No 453/2010) Version: 1.0/EN Revision date: 28/05/2012 Product name: Mono bromobenzene

Member State(s) concerned provide otherwise. It should also be noted that this SDS is applicable to the countries with English as an official language.

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