(MUS): CHRONIC PAIN and FATIGUE Guideline Summary
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VA/DoD CLINICAL PRACTICE GUIDELINE FOR THE MANAGEMENT OF MEDICALLY UNEXPLAINED SYMPTOMS (MUS): CHRONIC PAIN AND FATIGUE Guideline Summary PRIMARY CARE GUIDELINE SUMMARY • Establish that the patient has MUS. • Obtain a thorough medical history, physical examination, and medical record review. • Minimize low yield diagnostic testing. • Identify treatable cause (conditions) for the patient’s symptoms. • Determine if the patient can be classified as Chronic Multi-Symptom Illness (CMI) (i.e., has two or more symptoms clusters: pain, fatigue, cognitive dysfunction, or sleep disturbance). • Negotiate treatment options and establish collaboration with the patient. • Provide appropriate patient and family education. • Maximize the use of non-pharmacologic therapies: - Graded aerobic exercise with close monitoring. - Cognitive behavioral therapy (CBT) • Empower patients to take an active role in their recovery. VA access to full guideline: http://www.oqp.med.va.gov/cpg/cpg.htm May 2002 DoD access to full guideline: http://www.cs.amedd.army.mil/Qmo Sponsored & produced by the VA Employee Education System in cooperation with the Offices of Quality & Performance and Public Health & Environmental Hazards and the Department of Defense. Clinical Practice Guideline for Management of Medically Unexplained Symptoms: Chronic Pain and Fatigue 1 Patient with Medically Medically Unexplained symptoms (MUS) Unexplained Symptoms (MUS) [ A ] Patients with MUS: • Have unexplained symptoms after an 2 appropriate assessment. Obtain additional history, physical • May have been given one or more diagnoses examination, Mental Status Examination that lack a well-defined disease explanation. and psychosocial assessment [ B ] 3 4 Are unstable or urgent Y Refer or treat, as indicated, before condition(s) present? continuing in this algorithm [ C ] N 5 • Clarify the symptoms [See side bar] • Build therapeutic alliance Symptom Attributes • Schedule additional appointments of longer duration Duration of symptom [ D ] Onset and triggers Location Co-morbidity 6 Previous episodes Revisit the medical record Intensity and impact [ E ] Previous treatment and medications Past medical, surgical & psychological history Patient perception of symptom 7 [ D ] Obtain focused diagnostic tests, if not already done [ F ] 8 Can another condition or 9 disease (including mood Y Consider treating the disorder) explain condition or disease (cause) the symptoms? [ G ] 11 10 Y Are all symptoms Follow-up resolved? N N 12 Consider initiating symptom-based treatment modalities [ H ] Continued on Page 3 Management of Medially Unexplained Symptoms (MUS): Chronic Pain & Fatigue Summary page 2 Clinical Practice Guideline for Management of Medically Unexplained Symptoms: Chronic Pain and Fatigue Continued from Page 2 13 Does patient present with 2 or more of the following: • Fatigue Y • Pain • Sleep disturbance or cognitive dysfunction? [ I ] 14 Document diagnosis: Consider Anxiety, Sleep Apnea, Upper N Airway Resistance Syndrome, Fibromyalgia, Chronic Fatigue Syndrome or Chronic Multisymptom Illnesses [ J ] 22 Provide symptomatic treatment 15 and consider consultation Summarize the patient's condition [ Q ] Develop a treatment plan [ K ] 23 Follow-up and reassess as 16 indicated Initiate/continue treatment (See Section B 'Interventions') Consider symptomatic treatment Provide patient and family education [ L ] 17 Follow up with scheduled visits, usually at frequent intervals [ M ] Reassess symptoms severity [ N ] 18 Have symptoms and functional status Y improved? [ N ] N 21 19 Adjust dose or change treatment Adjust treatment modality (return to box 16) Encourage & reinforce Consider consultation Monitor for emerging conditions [ P ] [ O ] 20 Follow-up and reassess in 3 to 4 months Management of Medially Unexplained Symptoms (MUS): Chronic Pain & Fatigue Summary page 3 PRIMARY CARE MEDICALLY UNEXPLAINED orientation to place, memorizing and repeating three SYMPTOMS non-related items, and spelling “world” backwards). Patients managed by this guideline have symptoms that Psychosocial Assessment: A psychosocial assessment is remain relatively unexplained after an appropriate medical critical in evaluating the patient with unexplained symp- assessment that includes focused diagnostic testing. toms and should include a screening for suicidal ideation Patients are often given multiple labels that lack a well- and substance use disorders. The Patient Health defined disease explanation. Usual clinical features include Questionnaire (PHQ) is an excellent screening tool for a relative lack of objective signs and a chronic symptom assessing the presence of the most common psychiatric course often marked by exacerbations, remissions, and conditions associated with complaints of fatigue: depres- recurrences. Therefore, clinical management must be sion, symptoms, and anxiety. based largely upon patient report, rather than specific find- Unstable/Urgent Conditions ings on clinical examination or diagnostic testing. A Unstable or urgent conditions represent situations that compassionate approach to patients with medically unex- mandate immediate attention. A complete discussion of plained symptoms (MUS) is essential. diagnosis and management of the entire range of possible urgent conditions is beyond the scope of this ASSESSMENT AND DIAGNOSIS guideline. These conditions are generally recognized and A thorough and early review of all sources of informa- managed by the astute primary care clinician and tion can help in validating the patient’s health concerns, include (but are not limited to) the following: while communicating care and understanding—the • Suicidal ideation or psychosis necessary building blocks to an effective patient-clini- • Objective evidence of joint swelling cian partnership. Sources of information include: all • Fever (over 101.1 degrees F/38.4 degrees C) medical records, medical history and psychosocial • Significant weight loss assessment, review of systems, physical examination and mental status examination (MSE), routine test • Focal findings on neurological examination results, and standard health assessments. • Severe anemia or elevated white blood cells Symptoms Additional medical history: In obtaining a medical history, the clinician should focus on key symptoms that Patients who present with unexplained pain or fatigue may suggest a well-defined disease explanation. often carry a cluster of symptoms that must be under- stood as accurately as possible. Taking an accurate Physical examination: Patients with unexplained symp- history is an essential part of the diagnostic work-up. toms have often been examined several times in the past. The following brief standardized assessment measures However, important details may have been overlooked are recommended for routine recording in the medical due to time constraints or the frequency that clinicians record: encounter such complaints in the absence of objective findings. Setting aside time for a detailed and thorough For pain: "On a 0 to 10 scale, 0 being no pain and 10 examination is critical for the assessment and may also being pain as bad as you can imagine, what number help in building an alliance with the patient, who in would you say your pain has been over the past week?" many cases was seen by several clinicians. For symptoms other than pain: "On a 0 to 10 scale, 0 Mental Status Examination (MSE): A careful MSE being no (insert SYMPTOM) and 10 being (insert should be performed, including assessment of appear- SYMPTOM) as bad as you can imagine, what number ance, behavior, mood and affect, cognition, thought would you say your (insert SYMPTOM) has been over content and processes, and insight and judgment. A the past week?" useful screen for cognitive impairment in elderly For symptom impact: "During the past week, how patients consists of four questions from the Mini-Mental much have your symptoms interfered with your usual State Examination (MMSE) (i.e., orientation to time, Management of Medially Unexplained Symptoms (MUS): Chronic Pain & Fatigue Summary page 4 work or activities, 0 being does not interfere at all and for the presence of malignancy, which should be kept in 10 being completely interferes?" mind during the evaluation. It is important not to ignore co-morbidities that may represent a true underlying The clinician should initiate a complete initial symptom condition that will require treatment. assessment (e.g., symptom duration, onset, triggers, and severity for new symptoms not previously assessed). Previous episodes: The patient may have had prior episodes of similar symptoms in the past, as well as Duration: The duration of the symptoms until time of prior treatments. presentation is variable and patients may have spent years seeing numerous clinicians and undergoing exten- Patient perception of symptoms: Patients should be sive evaluations without ever obtaining a diagnosis. given the opportunity to relate their experiences and Many patients may relate the onset of their symptoms to complaints, at each visit, in their own way. Although a significant event (e.g., severe illness, trauma, military time-consuming and likely to include much seemingly mobilization, and viral illness). Some patients may irrelevant information, this has the advantage of present with symptoms after sustaining central/axial providing considerable information concerning the skeletal trauma, such as a motor vehicle accident with patient’s intelligence, emotional make-up and attitudes resultant whiplash. about their complaints. This