medRxiv preprint doi: https://doi.org/10.1101/2020.08.17.20164715; this version posted August 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Gusnanto A1,2, Earl KE3, Sakellariou GK3, Owens DJ4, Lightfoot A3, Fawcett S3, Owen E3, CA Staunton3, Shu T3, Croden FC1, Fenech M5, Sinclair M3, Ratcliffe L5, Whysall KA3, Haynes R1, Wells NM3, Jackson MJ3, Close GL4, Lawton C1, Beadsworth MBJ5, Dye, L1, McArdle A3. 1Human Appetite Research Unit, School of Psychology, University of Leeds, Leeds, UK; 2Department of Statistics, University of Leeds, Leeds, UK; 3Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, MRC-Arthritis Research UK and Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK. 4Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK; 5Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool University Hospitals Foundation Trust, Liverpool, UK. Corresponding Author Mike Beadsworth Email:
[email protected] Keywords: Mitochondria, skeletal muscle, cognition, PDGF. NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.08.17.20164715; this version posted August 21, 2020.