Bilaminar and Trilaminar Embryonic Disc
台大醫學院 解剖學暨細胞生物學研究所 黃敏銓老師實驗室
Graduate Institute of Anatomy and Cell Biology
Bilaminar and Trilaminar Embryonic Disc
黃敏銓
台大醫學院解剖學暨細胞生物學研究所 教授
1 First Week of Human Development
Fertilization Cleavage Blastulation Implantation
2 Cleavage
Day 4 Day 3 Day 2 Day 1 Blastocysts Morula Zygote
Day 5
Day 6 Day 0
3 Blastulation: Morula to Blastocyst
Day 4 Morula (12-cell to 32-cell stage) Zona pellucida Fallopian tube Blastulation Uterus
Day 5 Early blastocyst
Embryoblast (inner cell mass) Day 6 Late blastocyst Blastocystic cavity Trophoblast
4 Day 6 Early implantation
Embryonic pole
5 Day 7 Syncytiotrophoblast and Hypoblast
6 Second Week of Human Development
Bilaminar embryonic disc Amnionic cavity & amnion Umbilical vesicle Chorionic sac & connecting stalk
7 Day 8 The syncytiotrophoblast is rapidly expanding during implantation
羊膜
8 Day 9 Bilaminar embryonic disc Lacunae, Amnion, Primary umbilical vesicle
人絨毛膜促性腺激素 hCG: human chorionic gonadotropin
Exocoelomic membrane
Epiblast Hypoblast
(derived from hypoblasts) 9 Day 10 The 10-day conceptus (embryo and membranes) is completely embedded in the uterine endometrium
10 Day 12 Primordial uteroplacental circulation
11 Day 13 Primary chorionic villi
(Chorionic cavity)
12 Day 14 Secondary umbilical vesicle Connecting stalk prechordal plate
Extraembryonic splanchnic mesoderm
13 Third Week of Human Development
Gastrulation/Trilaminar disc Notochord formation Neurulation
14 Gastrulation from Bilaminar disc to Trilaminar disc
15 16 4. Oropharyngeal membrane 3. Primitive node 2. Primitive pit
9. Cloacal membrane 17 Trilaminar embryonic disc: ectoderm, mesoderm, endoderm
18 Day 15
19 Sacrococcygeal teratoma
derived from the primitive streak
Incidence: 1/35000
20 Day 16-18 Notochord
21 No intraembryonic mesoderm: 1. Oropharyngeal membrane 2. Notochord 3. Cloacal membrane
22 23 24 25 26 27 Day 18 Neurenteric canal
Neurenteric Cyst
Marilyn J. Siegel and Valerie Niehe
28 29 30 Notochord functions as the primary inducer of neural plate formation
31 32 Neurulation
33 34 Intraembryonic coelom (embryonic body cavity) Cardiogenic mesoderm
21 days
18 days
Lateral intraembryonic mesoderm
35 Day 21
Somites, Primordial cardiovascular system, Tertiary chorionic villi
Primordial cardiovascular system
Primordial heart Allantois
Cytotrophoblstic shell
Tertiary chorionic villus
Somite
36 bilaminar and trilaminar embryonic disc
37