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Course Syllabus Psychology 267 Clinical Neuroscience Larry Wichlinski Spring Term, 2016

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Course Syllabus Psychology 267 Clinical Neuroscience Larry Wichlinski Spring Term, 2016 1 Course Syllabus Psychology 267 Clinical Neuroscience Larry Wichlinski Spring Term, 2016 Office: Olin 123, Ext. 4377, e-mail: LWICHLIN Office Hours: Tuesday 1-3 p.m. Wed. 4a; Fri. 4a and by appointment Required Books: Pistorius, M. (2013). Ghost Boy. Nashville: Nelson Books. Introduction Welcome to Clinical Neuroscience! In this course we will examine the biological dimensions of disorders of the mind and brain. The goal is to gain a better understanding of the role that biological factors play when our brains and minds go awry. The format of this class will be a combination of lecture and discussion. The class is organized by brain disorder, but some themes recur throughout the course, as you will see. The bulk of the reading assignments are journal articles, most of them quite recently published. In addition, we will read selective websites and a contemporary book, Ghost Boy. Please have the assigned readings done by the time you get to class, if at all possible. Also, please have some form of the articles available during class time. Most of the journal articles are available via the Web of Knowledge through the library’s website. The few that are not available will be put on e-reserve for this course. I’ll let you know which articles fall in this category. I may add readings and/or substitute readings as this course unfolds. I will do my best to let you know of any changes in a timely fashion. Exams & Quizzes There will be two quizzes and two exams in this course. Quizzes will consist of multiple choice and short answer questions. The exams will be open book take- home tests consisting of a small number of open-ended integrative questions that will require you to summarize across a wide range of articles. Make-up exams and quizzes will be given only in cases of personal illness or family emergency. 2 Special Needs Please let me know if you have special needs. I will work with you to accommodate those needs. Class Project Everyone will be required to do an individual class project. Your task will be to research the neurobiology of a disorder that we have NOT covered in this course. You will generate an annotated bibliography of 10-15 articles that were published in the last three years. I will give you a separate handout for that assignment. Grades The breakdown for each component of the course is as follows: 1st quiz 10% 2nd quiz 10% Class Project 20% Midterm Exam 25% Final Exam 25% Class Participation 10% You may take a quiz early if a college activity requires that you leave campus on the day the exam is scheduled. Please make arrangements with me at least a week before you want to take it. E-tiquette Please turn off your cell phones during class, unless you’re using them to access assigned readings. Also, I don’t mind people using computers during class, as long as it’s for taking notes and classroom-related activities. (Facebook and Instagram do not count as classroom activities). Miscellaneous I will try to stick as close to the syllabus as I possibly can. However, I may alter the amount of time we spend on any individual topic. Should you need to see me, please do not hesitate to stop by during my office hours, or at some other time if my office hours are not convenient for you. Just make an appointment with me. 3 I do not generally answer e-mail on weekends. I will respond to your e-mail as soon as I can when I get back to my office on Monday. I believe that this is one course whose investment in time and energy has great long-term payoff. I hope you do, too. Have a great term! Date Day Topic and Assignment Mar. 28th Mon. Introduction & Overview Easter Monday Mar. 30th Wed. Foundations of Neuroscience I: Brain Structures Assignment: Bryn Mawr website (URL in reference section) April 1st Fri. Foundations II: Neurons & Glia Assignment: University of Bristol website links (URLs in reference section) April Fool’s Day April 4th Mon. Foundations III: Electrical Potentials Assignment: Lovinger (NIAAA website) April 6th Wed. Foundations IV: Synaptic Transmission Assignment: TBA April 8th Fri. Foundations V: Chemicals of the Nervous System Assignment: TBA April 11th Mon. Schizophrenia Assignment: Bakhshi & Chance (2015); Leza et al (2015); NIMH website on schizophrenia April 13th Wed. Mood Disorders I: Bipolar Disorder Assignment: Marangoni et al (2016); Muneer (2016); Proudfoot et al (2012) April 15th Fri. Mood Disorders II: Anatomy of Depression Assignment: Hamani et al (2011); Li et al (2013); Pandya et al (2012) April 18th Mon. QUIZ Mood Disorders III: Biology of Depression Assignment: Huang et al, (2014); Lopizzo et al (2015); Sibille & French (2013) Taxes Due 4 April 20th Wed. Mood Disorders IV: SAD Assignment: Praschak-Rieder & Willeit (2012); Carlson et al (2013) April 22nd Fri. Mood Disorders V: Treatment Assignment: Galvez et al (2015); Meron et al (2015) Earth Day; Passover begins at sundown April 25th Mon. Anxiety Disorders I: GAD Assignment: Huh et al (2011); NIMH website on GAD April 27th Wed. Anxiety Disorders II: Panic Disorder Assignment: Montoya et al (2016); Shin et al (2013) April 29th Fri. Trauma Disorders: PTSD Assignment: Moustafa (2013); Norman et al (2013) May 2nd Mon. NO CLASS—MIDTERM BREAK May 3rd Tues. TAKE HOME EXAMS DUE BY 4:30 p.m. May 4th Wed. OCD Assignment: Burguiere et al (2015); Islam et al (2015); O’Neill et al (2013); Thorsen et al (2015) May 6th Fri. Substance Abuse I: General Mechanisms of Addiction Assignment: Koob (2015); Volkow & Morales (2015); NIDA website on The Science of Addiction May 8th Sun. Mother’s Day May 9th Mon. Substance Abuse II: Alcoholism Assignment: Hagele et al (2014); Tabakoff & Hoffman (2013) May 11th Wed. Disorders of Impulse Control Assignment: Bari & Robbins (2013) + TBA May 13th Fri. Ghost Boy Assignment: pp. 1-95 May 16th Mon. Ghost Boy Assignment: pp. 97-257 May 18th Wed. Quiz 2 + Epilepsy Assignment Shin et al (2011) 5 May 20th Fri. Traumatic Brain Injury Assignment: Iverson et al (2015); Karr et al (2014) May 23rd Mon. Multiple Sclerosis & Amyotrophic Lateral Sclerosis (ALS) Assignment: Belbasis et al (2015); Ontaneda et al (2012); Orsini et al (2015) Victoria Day (Canada) May 25th Wed. Parkinson’s Disease Assignment: Dunning et al (2012); Goldman (2014) May 27th Fri. Alzheimer’s Disease Assignment: Blennow et al (2015) Medical News Today Report (2013) Williams (2013) May 30th Mon. NO CLASS Memorial Day May 31st Tues. CLASS PROJECTS DUE BY 4:30 P.M. June 1st Wed. Wrap-up June 6th Mon. TAKE HOME FINAL EXAM DUE BY 4:30 P.M. Electronic Submission O.K. Reserve Readings Bakhshi, K. & Chance, S. A. (2015). The neuropathology of schizophrenia: A selective review of past studies and emerging themes in brain structure and cytoarchitecture. Neuroscience, 303, 82-102. Bari, A. & Robbins, T. W. (2013). Inhibition and impulsivity: Behavioral and neural basis of response control. Progress in Neurobiology, 108, 44-79. Belbasis, L., Bellou, V., Evangelou, E., Ioannidis, J. P. A., & Tzoulaki, I. (2015). Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. Lancet Neurology, 14, 263-273. Blennow, K., Mattsson, N., Schöll, M., Hansson, O., & Zetterberg, H. (2015). Amyloid biomarkers in Alzheimer’s disease. Trends in Pharmacological Sciences, 36, 297- 309. Burguiere, E., Monteiro, P., Mallet, L., Feng, G., & Graybiel, A. M. (2015). Striatal circuits, habits, and implications for obsessive-compulsive disorder. Current Opinion in Neurobiology, 30, 59-65. 6 Bryn Mawr College. Organization of the nervous system. http://serendip.brynmawr.edu/exchange/brains/structures Retrieved on January 7th, 2014. Carlson, P. J., Diazgranados, N., Nugent, A. C. (2013). Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: A preliminary positron tomography study. Biological Psychiatry, 73, 1213-1221. Dunning, C. J. R., Reyes, J. F., Steiner, J. A., & Brundin, P. (2012). Can Parkinson’s disease be propagated from one neuron to another. Progress in Neurobiology, 97, 205-219. Galvez, J. F., Keser, Z., Mwangi, B. et al (2015). The medial forebrain bundle as a deep stimulation target for treatment resistant depression: A review of published data. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 58, 59-70. Goldman, S. M. (2014). Environmental toxins and Parkinson’s disease. Annual Review of Pharmacology & Toxicology, 54, 141-164. Hamani, C., Mayberg, H., Stone, S. et al. (2011). The subcallosal cingulate gyrus in the context of major depression. Biological Psychiatry, 69, 301-308. Huang, X., Huang, P., Li, P., Li, D., Zhang, Y., Wang, T., Mu, J., Li, Q., & Xie, P. (2015). Early brain changes associated with psychotherapy in major depressive disorder revealed by resting-state fMRI: Evidence for the top- down regulation theory. International Journal of Psychophysiology, 94, 437-444. Huh, J., Goebert, D., Goebert, D., Takeshita, J. et al (2011). Treatment of generalized anxiety disorder: A comprehensive review of the literature for psychopharmacologic alternatives to newer antidepressants and benzodiazepines. Primary Care Companion CNS Disorders, 13. Islam, L., Franzini, A., Messina, G., Scarone, S., Gambini, O. (2015). Deep brain stimulation of the nucleus accumbens and bed nucleus of stria terminalis in obsessive-compulsive disorder: A case series. World Neurosurgery, 83, 657- 663. Iverson, G. L., Gardner, A. J., McCrory, P., Zafonte, R., & Castellani, R. J. (2015). A critical review of chronic traumatic encephalopathy. Neuroscience and Biobehavioral Reviews, 56, 276-293. Jiang, T., Zhou, Y, & Liu et al (2013). Brainnetome-wide association studies in schizophrenia: The advances and future. Neuroscience and Biobehavioral Reviews, 37, 2818-2835. Karr, J. E., AReshenkoff, C.
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