Supplemental information

Supplemental Material and Methods

Isolation of mononuclear cells from the frest ovarian tumor specimens

Fresh ovarian tumor specimens were minced with scissors, digested in PBS containing 1 mg/mL of Collagenase D (Roche) and 100μg/mL DNase I at 37°C for 30 min, mechanically dissociated using the gentleMACS dissociator (Miltenyi Biotec) and passed through a 100µm nylon cell strainer (BD Biosciences).

Degranulation and IFNγ production after in vitro stimulation

Mononuclear cells isolated from fresh tumor specimens were stimulated with 50 ng/mL phorbol

12-myristate 13-acetate (PMA) + 1 μg/mL ionomycin in the presence of anti-CD107a FITC monoclonal antibody (BioLegend) for 1h followed by 3h incubation with brefeldin A

(BioLegend). Unstimulated cells were used as control. Cells were then washed in PBS, stained with anti-CD45 PerCP (EXBIO), anti-CD3 Alexa Fluor 700 (EXBIO), anti-CD4 ECD

(Beckman Coulter) and anti-CD8 HV500 (BD Biosciences) monoclonal antibodies, fixed in fixation/permeabilization buffer (eBioscience), further permeabilized with permeabilization buffer (eBioscience) and stained with anti-IFNγ PE-Cy7 (eBioscience), anti-GZMB Brilliant

Violet 421 (BD Biosciences) and anti-PRF1 APC (BioLegend) monoclonal antibodies. The percentage of CD3+CD8+ T cells producing IFNγ and degranulating upon PMA/ionomycin stimulation were determined by flow cytometry. The data were analyzed with the FlowJo software package (Tree Star, Inc.).

“Expression profile of co-inhibitory receptors on CD8+ T cells upon exposure to rIFNγ in vitro”

Mononuclear and malignant cells were isolated from fresh HGSC specimens and cultured with rIFNγ under different conditions (Supplementary Fig. 6A). (1) Malignant cells and leukocytes were co-cultured in presence or absence of 20ng/mL rIFNγ for 24 hours. (2) Malignant cells were isolated from freshly resected HGSC samples by positive selection on EpCAM+ cells using Human EpCAM kit (EasySepTM). Population of isolated leukocytes were separately cultured with or without rIFNγ for 24 hours. (3) Malignant cells and leukocytes separated using positive selection on EpCAM+ cells by Human EpCAM kit (EasySepTM) were co-cultured in conditions of transwell separation (no physical contact) with or without rIFNγ for 24 hours.

Furthermore, cells were washed in PBS, stained with anti-CD45 PE-Texas Red (Life

Technologies), anti-CD3 A700 (EXBIO), anti-CD4 PE-Cy7 (eBioscience), anti-CD8 HV500

(BD Biosciences), anti-PD-L1 BV421 (BioLegend), anti-PD-1 FITC (BioLegend), anti-CTLA4

APC (BioLegend) monoclonal antibodies. The percentage of CD45+CD3+CD8+PD-L1+, CD45+

CD3+CD8+PD-1+ and CD45+CD3+CD8+CTLA-4+ were determined by flow cytometry. The data were analyzed with the FlowJo software package (Tree Star, Inc.).

Library preparation and sequencing

Twenty FFPE samples suitable for library preparation according to quality/quantity evaluations were processed following the manufacturer’s specifications with minor modifications by using the Illumina TruSeq® RNA Access Library Prep (Illumina) along with purification steps employing SPRI beads. DV200 values for all samples exceeded 40%, and 100 ng of total RNA was used for the cDNA synthesis. Each library was quantified with the fluorimeter Qubit 2.0

(dsDNA HS kit; Thermo Fisher), and the size distribution was determined using a DNA 1000 kit on a 2100 Bioanalyzer instrument prior to pooling. All libraries had a similar size distribution of approximately 260 bp. A 4-plex pool of libraries was made by combining 200 ng of each DNA library. The libraries were sequenced on an Illumina NextSeq 500. At least

180 M pair-end 2x75 bp reads were generated per library. The libraries were prepared and sequenced at EMBL Genomics Core Facility (Heidelberg, Germany).

NGS data processing

The raw FASTQ sequencing files were aligned to human reference genome (build h19) with bowtie2 (version 2.3.2) and tophat2 (version 2.1). The levels of expression as raw “counts” were calculated from aligned reads with mapping quality at least 10 using htseq-count (version

0.6.0). Count files were transferred to the GALAXY environment (Galaxy version 18.01), and differentially expressed genes (DEGs) between groups were determined using DEseq2 (Galaxy

Version 2.11.40.1) with default settings (Love et al, Genome Biology, 2014).

Supplemental figures

Supplemental Figure 1. Experimental design of the study.

Supplemental Figure 2. Tumor infiltration by CD8+ T cells, CD20+ B cells and DC-LAMP+ cells correlate with prolonged survival in patients with HGSC. (A) Representative images of CD8, CD20 and DC-LAMP immunostaining. Scale bar = 50 µm. RFS (B) and OS (C) of 80 patients with HGSC who did not receive neoadjuvant chemotherapy, upon stratifying patients based on median density of CD8+, CD20+ and DC-LAMP+ cells in the tumor microenvironment. Survival curves were estimated by the Kaplan-Meier method, and differences between groups were evaluated using log-rank test. Number of patients at risk are reported. RFS (D) and OS (E) of HGSC patients who did not receive neoadjuvant chemotherapy, upon stratification based on median density of CD8+ cells plus CD20+ cells and

CD8+ cells plus DC-LAMP+ cells, respectively.

Supplemental Figure 3. Representative images of PD-L1 (scale bar = 100 μm) and PD-1

(Scale bar = 50 μm ) immunostaining.

Supplemental Figure 4. Representative images of CTLA4 (scale bar = 50 μm) and LAG-

3 (Scale bar = 50 μm ) immunostaining.

Supplemental Figure 5. PD-L1 levels and infiltration by PD-1+, CTLA4+ and LAG-3+ cells were heterogeneous across samples but did not differ based on site of assessment. PD-L1 levels and density of PD-1+, CTLA-4+ and LAG-3+ in the tumor stroma and tumor nest (A) and among different pathological disease stages (B) of patients with HGSCs (n=80).

Supplemental Figure 6. PD-L1, PD-1 and CTLA4 expression on freshly isolated CD8+ T cells after exposure to recombinant IFNγ. (A) Experimental design of study. (B) Gating strategy for CD8+ T cells. The percentage of cells in each gate is reported. (C) Percentage of

PD-L1+, PD-1+ and CTLA4+ CD8+ T cells from 9 HGSC patients before and after rIFNγ treatment as determined by flow cytometry.

Supplemental Figure 7. Representative images of 3 different samples of PD-1Lo/CD8Lo, PD-

1Hi/CD8Hi, PD-1Lo/CD20/DC-LAMPLo and PD-1Hi/CD20/DC-LAMPHi immunostaining.

Scale bar = 100 μm.

Supplemental Figure 8: The combined prognostic impact of CD8+ T cells and PD-1+, LAG-

3+ and CTLA4+ cells in HGSC. RFS and OS of HGSC patients who did not receive neoadjuvant chemotherapy, upon stratification based on median density of CD8+ T cells and

PD-1+ cells (A), CD8+ T cells and LAG-3+ cells (B) and CD8+ T cells and CTLA4+ cells (C).

Survival curves were estimated by the Kaplan-Meier method, and differences between groups were evaluated using log-rank test. Number of patients at risk are reported. (D) Fold change of

CD8+ IFNγ+ T cells from 4 TIM-3Lo versus 4 TIM-3Hi patients after incubation with anti-PD-1, anti-TIM-3, anti-CTLA4 antibodies, alone or in combination.

Study group 2 Variable (n=20) Age:

Mean age (y) ± SEM 60.9 ± 2 Range 44-78 pTNM stage: Stage I 0 (0%) Stage II 6 (30%) Stage III 14 (70%) Debulking R0 8 (40%) R1 1 (5%) R2 11 (55%)

Supplemental table 1. Main clinical and biological characteristics of 20 HGSC patients in which the freshly resected tumors were analyzed using flow cytometry (Study group 2).

Target Parameter Source Producer Clone Retrieval Detection system Revelation Dilution Incubation solution time (min) CD8 rabbit Spring Bioscience SP16 pH8 EnVision™+/HRP, Rabbit DAB+ substrate Chromogen system 1:80 30 ImmPRESS-AP anti-mouse ImmPACT Vector red Alkaline CD20 mouse Dako L26 pH8 1:250 60 IgG (alkaline phosphatase) Phosphatase substrate kit Santa Cruz CTLA-4 mouse F-8 pH9 EnVision™+/HRP, Mouse DAB+ substrate Chromogen system 1:200 120 Biotechnology, Inc 1010E1.0 donkey anti-rat IgG-biot DC-LAMP rat Dendritics pH8 DAB+ substrate Chromogen system 1:80 60 1 (Jackson ImmunoResearch) Impress HRP anti-mouse IgG LAG-3 mouse Novus Biologicals 17B4 pH9 DAB+ substrate Chromogen system 1:150 90 (Peroxidase) Polymer Impress HRP anti-mouse IgG PD-1 mouse Abcam NAT105 pH9 DAB+ substrate Chromogen system 1:50 60 (Peroxidase) Polymer Impress HRP anti-rabbit IgG PD-L1 rabbit Ventana SP142 pH6 DAB+ substrate Chromogen system 1:50 60 (Peroxidase) Polymer Supplemental Table 2. The list of antibodies used for IHC staining.

Parameter Source Producer Clone Fluorochrome Dilution

CD107a mouse BioLegend H4A3 FITC 8:100 CD3 mouse EXBIO MEM-57 Alexa 700 5:100 CD4 mouse eBioscience RPA-T4 PE-Cy7 5:100 Beckman CD4 mouse SFCI12T4D11 ECD 5:100 Coulter Life CD45 mouse HI30 PE-Texas Red 6:100 technologies CD45 mouse EXBIO MEM-28 PerCP 6:100 CD8 mouse BD Biosciences RPA-T8 HV500 5:100 CTLA4 mouse BioLegend L3D10 APC 6:100 Granzyme mouse BD Biosciences GB11 BV421 4:100 IFNg murine eBioscience 4S.B3 PE-Cy7 1:100 PD-1 mouse BioLegend EH12.2H7 APC 6:100 PD-1 mouse BioLegend EH12.2H7 FITC 6:100 PD-1 mouse BioLegend EH12.2H7 PB 6:100 PD-L1 mouse BioLegend 29E.2A3 BV421 4:100 Perforin mouse BioLegend dG9 APC 4:100 TIM-3 mouse BioLegend F38-2E2 PE 3:100

Supplemental table 3. The list of antibodies used for flow cytometry.

Myeloid CD8 Cytotoxic Monocytic T cells B lineage NK cells dendritic Neutrophils Endothelial cells Fibroblasts T cells lymphocytes lineage cells

CD28 CD8B CD8A BANK1 CD160 ADAP2 CD1A CA4 ACVRL1 KDR COL1A1 CD3D EOMES CD19 KIR2DL1 CSF1R CD1B CEACAM3 APLN MMRN1 COL3A1 CD3G FGFBP2 CD22 KIR2DL3 FPR3 CD1E CXCR1 BCL6B MMRN2 COL6A1 CD5 GNLY CD79A KIR2DL4 KYNU CLEC10A CXCR2 BMP6 MYCT1 COL6A2 CD6 KLRC3 CR2 KIR3DL1 PLA2G7 CLIC2 CYP4F3 BMX PALMD DCN CHRM3-A5 KLRC4 FCRL2 KIR3DS1 RASSF4 WFDC21P FCGR3B CDH5 PEAR1 GREM1 CTLA-4 KLRD1 IGKC NCR1 TFEC HAL CLEC14A PGF PAMR1 FLT3LG MS4A1 PTGDR KCNJ15 CXorf36 PLXNA2 TAGLN ICOS PAX5 SH2D1B MEGF9 EDN1 PTPRB MAL SLC25A37 ELTD1 ROBO4 MGC40069 STEAP4 EMCN SDPR PBX4 TECPR2 ESAM SHANK3 SIRPG TLE3 ESM1 SHE THEMIS TNFRSF10C FAM124B TEK TNFRSF25 VNN3 HECW2 TIE1 TRAT1 HHIP VEPH1 VWF

Supplemental Table 4. The list of genes used by MCP counter for identification of distinct cell populations.

Cell signaling Parameter Dilution ImmunoReagent Revelation Dilution Technology (clone) UltraPolymer Goat anti- CD8 C8/144b 1:500 Tyramide-CFDye 568 1:200 mouse (ready to use) UltraPolymer Goat anti-rabbit PD-1 D4W2J 1:500 Tyramide-CFDye 488 1:200 (ready to use) UltraPolymer Goat anti-rabbit TIM-3 D5D5R 1:400 Tyramide-CFDye 680 1:200 (ready to use)

Supplemental Table 5. The list of antibodies used for in situ immunofluorescence staining.

Gene symbol Base mean log2FC stdErr Wald-Stats P-value P-adj NEUROD4 18.661 -24.149 3.045 -7.932 2.16E-15 5.04E-11 KRTAP13-1 14.095 -23.779 3.035 -7.835 4.69E-15 5.04E-11 PHOX2B 10.509 -23.753 3.045 -7.802 6.11E-15 5.04E-11 SMEK3P 11.050 -23.562 3.045 -7.739 1.00E-14 6.21E-11 IGKV1-27 5770.836 -6.618 1.027 -6.445 1.16E-10 4.76E-07 IFNA7 6.767 -6.249 1.797 -3.477 0.000506 0.035915 IGHV2-70 193.787 -6.234 1.139 -5.472 4.44E-08 5.5E-05 IGHV3-33 4336.947 -6.066 1.075 -5.644 1.67E-08 2.42E-05 ADAM2 39.952 -5.927 1.289 -4.597 4.28E-06 0.002149 IGKV2-30 642.831 -5.714 0.956 -5.977 2.27E-09 5.62E-06 S100A7A 16.699 -5.649 1.557 -3.629 0.000285 0.025232 S100A7 85.090 -5.521 1.095 -5.041 4.64E-07 0.000394 IGLC6 46.683 -5.505 0.931 -5.912 3.38E-09 7.61E-06 IGKV2D-28 78.606 -5.363 1.199 -4.474 7.69E-06 0.002951 DPPA2 15.909 -5.259 1.341 -3.921 8.81E-05 0.013292 IGHV6-1 66.482 -5.186 1.030 -5.035 4.78E-07 0.000394 IGLV2-23 1994.209 -5.138 0.892 -5.759 8.48E-09 1.32E-05 IGHV1-2 1038.372 -5.130 0.811 -6.325 2.53E-10 8.95E-07 IGHV3-20 263.666 -5.050 0.812 -6.220 4.98E-10 1.38E-06 FGB 6.613 -5.007 1.401 -3.574 0.000351 0.02891 IGHV3-64 72.118 -4.984 1.100 -4.529 5.92E-06 0.002523 IGHV3-73 1559.450 -4.928 0.928 -5.309 1.10E-07 0.000124 IGKV1-39 23.421 -4.824 0.987 -4.888 1.02E-06 0.0007 OR4M2 58.078 -4.803 1.207 -3.979 6.93E-05 0.011433 IGKV2-28 5.694 -4.785 1.383 -3.461 0.000539 0.037428 IGHV4-31 2048.970 -4.768 1.039 -4.590 4.43E-06 0.002149 IGHV3OR16-9 10.937 -4.727 1.377 -3.434 0.000596 0.040052 OLFM4 49.859 -4.713 1.099 -4.289 1.79E-05 0.004925 IGHA1 8760.555 -4.583 0.783 -5.857 4.72E-09 8.97E-06 PIGR 519.961 -4.551 0.937 -4.856 1.20E-06 0.000801 IGHV3-74 1203.296 -4.453 0.716 -6.218 5.03E-10 1.38E-06 IGLV3-1 2317.657 -4.433 0.767 -5.783 7.35E-09 1.3E-05 IGKV6-21 37.629 -4.414 1.132 -3.898 9.71E-05 0.01406 IGLV2-5 13.104 -4.266 1.271 -3.357 0.000788 0.047608 IGLV2-11 515.893 -4.244 0.818 -5.190 2.11E-07 0.000217 IGHV3-53 643.927 -4.241 0.885 -4.790 1.67E-06 0.001007 IGKV1D-8 86.819 -4.233 0.939 -4.506 6.59E-06 0.002764 IGHV3-72 224.412 -4.214 0.944 -4.464 8.06E-06 0.002991 PRSS41 16.892 -4.155 1.091 -3.808 0.00014 0.017142 IGHD 198.990 -4.121 0.733 -5.620 1.91E-08 2.63E-05 SAA2 49.151 -4.067 1.091 -3.728 0.000193 0.020642 IGKV2-24 247.062 -4.048 0.969 -4.178 2.94E-05 0.006774 IGLV3-25 491.412 -3.973 0.937 -4.242 2.21E-05 0.005562 GPR15 13.193 -3.969 1.057 -3.755 0.000173 0.019561 CCL24 21.266 -3.965 0.971 -4.084 4.42E-05 0.008406 HOXA11 13.185 -3.951 0.868 -4.552 5.30E-06 0.002418 IGHV3-30 890.908 -3.950 0.972 -4.065 4.81E-05 0.008807 IGLV7-43 107.411 -3.875 0.846 -4.580 4.65E-06 0.002174 IGKV1-16 883.606 -3.853 0.847 -4.550 5.38E-06 0.002418 IGHV4-61 601.741 -3.836 0.858 -4.472 7.76E-06 0.002951 IGLV3-21 619.013 -3.832 0.714 -5.364 8.16E-08 9.61E-05 ANKRD30A 21.420 -3.799 1.037 -3.663 0.00025 0.023645 IGLV5-45 30.669 -3.786 0.884 -4.282 1.85E-05 0.004971 IGHV3-21 1755.927 -3.758 0.957 -3.928 8.56E-05 0.013039 IGKV1-5 33961.921 -3.723 0.959 -3.881 0.000104 0.014363 IGHV3-7 1442.447 -3.677 0.850 -4.326 1.52E-05 0.00448 IGHV1-18 945.537 -3.671 0.874 -4.200 2.66E-05 0.00646 IGHD3-3 2.649 -3.667 0.924 -3.969 7.22E-05 0.011748 MYO18B 129.384 -3.616 0.948 -3.813 0.000137 0.016914 IGLV6-57 159.639 -3.607 0.835 -4.320 1.56E-05 0.004481 FCRL1 28.905 -3.600 0.977 -3.684 0.000229 0.022165 IGLV2-18 42.921 -3.598 0.972 -3.704 0.000212 0.021571 IGKV1-12 588.052 -3.590 0.830 -4.326 1.52E-05 0.00448 IGLV10-54 10.567 -3.589 0.970 -3.701 0.000215 0.02166 PI16 165.405 -3.551 0.833 -4.264 2.00E-05 0.005165 CD70 6.687 -3.537 0.894 -3.956 7.61E-05 0.012042 FCER2 9.854 -3.531 0.861 -4.101 4.11E-05 0.008249 IGHV4-4 181.837 -3.528 1.057 -3.339 0.000842 0.049283 IGHV3-11 1652.034 -3.508 0.856 -4.096 4.20E-05 0.008249 IGHJ5 45.502 -3.501 0.802 -4.363 1.29E-05 0.004075 JSRP1 32.176 -3.487 0.864 -4.034 5.48E-05 0.009725 IGHV3-49 753.187 -3.456 0.932 -3.710 0.000207 0.021526 IGKV4-1 982.229 -3.453 0.896 -3.856 0.000115 0.015085 IGHG2 4687.479 -3.452 0.775 -4.456 8.34E-06 0.002991 PAX5 29.107 -3.426 0.922 -3.717 0.000202 0.021333 RP11-1102P16.1 21.173 -3.424 0.879 -3.895 9.84E-05 0.01406 OR14J1 9.108 -3.397 0.991 -3.427 0.000611 0.040381 IGLV1-36 13.117 -3.348 0.979 -3.422 0.000622 0.041025 RP11-457K10.2 4.590 -3.323 0.992 -3.352 0.000803 0.047982 IGHV3-15 2232.558 -3.312 0.945 -3.507 0.000454 0.034045 CCL13 43.907 -3.307 0.862 -3.835 0.000126 0.015921 OLFM3 107.965 -3.303 0.858 -3.851 0.000118 0.015155 IGHJ4 28.107 -3.282 0.889 -3.692 0.000222 0.021811 IGLC2 12303.578 -3.276 0.731 -4.481 7.43E-06 0.002951 IGKV1-17 908.297 -3.276 0.880 -3.721 0.000198 0.021145 IGHA2 800.416 -3.260 0.815 -3.999 6.37E-05 0.010709 PLA2G2D 56.027 -3.246 0.927 -3.502 0.000462 0.034435 IGLL5 10.711 -3.220 0.923 -3.488 0.000487 0.035554 C15orf53 5.331 -3.214 0.955 -3.367 0.00076 0.046533 IGLV4-69 41.010 -3.203 0.793 -4.038 5.39E-05 0.009725 IGLV2-14 1549.317 -3.193 0.861 -3.707 0.00021 0.021571 IGHM 3851.607 -3.190 0.768 -4.154 3.27E-05 0.007177 IGLV2-8 774.030 -3.182 0.829 -3.838 0.000124 0.015788 LMX1B 27.027 -3.165 0.709 -4.462 8.13E-06 0.002991 IGJ 1686.058 -3.158 0.731 -4.321 1.56E-05 0.004481 CD79A 130.630 -3.133 0.664 -4.719 2.37E-06 0.001332 FCRL5 389.498 -3.115 0.705 -4.421 9.83E-06 0.003376 PPP2R2C 198.038 -3.063 0.747 -4.098 4.17E-05 0.008249 IGHGP 1879.197 -3.057 0.788 -3.880 0.000104 0.014363 KIAA0125 68.868 -3.053 0.584 -5.233 1.67E-07 0.00018 IGHJ6 25.892 -3.047 0.695 -4.387 1.15E-05 0.003844 SCGB1A1 8.294 -3.040 0.830 -3.664 0.000248 0.023614 IGHV3-23 1749.552 -3.032 0.798 -3.798 0.000146 0.017637 EBF2 137.522 -3.019 0.744 -4.058 4.95E-05 0.009002 BHLHE22 14.901 -3.006 0.675 -4.456 8.35E-06 0.002991 HOXA9 54.005 -2.985 0.846 -3.527 0.00042 0.03275 FCRL2 31.034 -2.978 0.647 -4.603 4.16E-06 0.002146 IGHG1 128715.915 -2.963 0.768 -3.856 0.000115 0.015085 SYT8 10.544 -2.960 0.817 -3.624 0.00029 0.025531 IGHG3 3783.260 -2.952 0.616 -4.795 1.63E-06 0.001006 SLC4A1 41.918 -2.948 0.683 -4.316 1.59E-05 0.004523 CXCR1 29.401 -2.947 0.757 -3.895 9.83E-05 0.01406 IGLV4-60 11.525 -2.945 0.778 -3.785 0.000154 0.018094 DPT 393.198 -2.943 0.755 -3.897 9.75E-05 0.01406 OR51C1P 4.603 -2.940 0.847 -3.473 0.000515 0.036291 IGKJ5 16.847 -2.935 0.835 -3.515 0.00044 0.033472 MS4A1 269.401 -2.928 0.754 -3.884 0.000103 0.014363 HBB 8716.633 -2.900 0.631 -4.594 4.35E-06 0.002149 GNLY 91.899 -2.872 0.597 -4.813 1.49E-06 0.000945 HBA1 2419.865 -2.846 0.644 -4.422 9.79E-06 0.003376 FCRLA 13.240 -2.842 0.811 -3.506 0.000454 0.034045 TNFSF9 7.809 -2.840 0.686 -4.142 3.44E-05 0.007402 ARL14 7.899 -2.835 0.779 -3.638 0.000274 0.025046 EPYC 124.548 -2.834 0.830 -3.412 0.000645 0.042084 TRAV14DV4 4.028 -2.829 0.813 -3.478 0.000505 0.035915 PADI4 14.938 -2.827 0.773 -3.654 0.000258 0.024147 DLGAP2 51.732 -2.798 0.721 -3.880 0.000105 0.014363 CCL23 9.983 -2.797 0.745 -3.754 0.000174 0.019561 C1orf110 18.680 -2.794 0.757 -3.692 0.000222 0.021811 SHISA3 26.944 -2.780 0.790 -3.520 0.000431 0.032981 CCL19 85.316 -2.772 0.787 -3.525 0.000424 0.03275 HBA2 5561.499 -2.755 0.630 -4.373 1.23E-05 0.003941 POU2AF1 167.839 -2.753 0.551 -4.999 5.77E-07 0.000446 IFNG 15.827 -2.751 0.693 -3.969 7.21E-05 0.011748 IGLC3 10064.687 -2.739 0.725 -3.776 0.00016 0.018473 HOXA5 180.132 -2.736 0.741 -3.691 0.000223 0.021811 MS4A2 78.176 -2.736 0.819 -3.341 0.000836 0.049283 SIGLEC12 26.306 -2.728 0.719 -3.796 0.000147 0.017637 SCARA5 107.713 -2.718 0.798 -3.406 0.00066 0.042611 FCRL3 83.453 -2.716 0.663 -4.097 4.18E-05 0.008249 CHRDL2 55.802 -2.693 0.528 -5.100 3.39E-07 0.000311 IRF4 224.448 -2.692 0.558 -4.826 1.39E-06 0.000905 FRMD7 41.722 -2.681 0.769 -3.487 0.000489 0.035554 IGLC7 184.843 -2.658 0.795 -3.342 0.000832 0.049283 TBX21 24.661 -2.652 0.616 -4.307 1.66E-05 0.004657 FAM172BP 8.240 -2.642 0.713 -3.703 0.000213 0.021571 VNN3 118.856 -2.640 0.737 -3.581 0.000343 0.028553 EMR3 38.644 -2.621 0.731 -3.586 0.000336 0.02816 NCR3 9.659 -2.614 0.692 -3.779 0.000157 0.018424 CCL17 4.573 -2.612 0.756 -3.455 0.000551 0.03819 RPE65 51.608 -2.609 0.740 -3.527 0.00042 0.03275 XPNPEP2 40.075 -2.605 0.741 -3.514 0.000442 0.033472 RHOH 22.399 -2.595 0.573 -4.530 5.89E-06 0.002523 SLAMF7 295.112 -2.592 0.530 -4.889 1.01E-06 0.0007 CCL18 76.933 -2.591 0.746 -3.471 0.000518 0.036367 HEMGN 27.330 -2.585 0.712 -3.629 0.000284 0.025232 TACR2 59.248 -2.585 0.506 -5.107 3.28E-07 0.000311 IGKJ4 45.769 -2.579 0.750 -3.440 0.000581 0.039512 CXCL13 221.959 -2.574 0.720 -3.575 0.00035 0.02891 C16orf54 14.157 -2.553 0.653 -3.911 9.18E-05 0.013676 NCR1 18.123 -2.544 0.604 -4.212 2.53E-05 0.006254 MZB1 84.974 -2.524 0.544 -4.635 3.57E-06 0.001918 FOXC2 49.818 -2.511 0.597 -4.209 2.57E-05 0.006288 GTSF1 22.910 -2.510 0.738 -3.403 0.000666 0.042783 S100A8 118.476 -2.501 0.663 -3.775 0.00016 0.018473 CAPN8 131.518 -2.489 0.656 -3.796 0.000147 0.017637 LAX1 116.855 -2.487 0.492 -5.051 4.40E-07 0.000388 HOXA10 147.480 -2.487 0.564 -4.408 1.04E-05 0.003532 RP11-131H24.4 37.500 -2.460 0.725 -3.392 0.000693 0.04394 SH2D1A 100.510 -2.442 0.638 -3.828 0.000129 0.016325 TRAT1 58.485 -2.440 0.628 -3.885 0.000102 0.014363 HOXC9 35.240 -2.436 0.661 -3.683 0.000231 0.022182 P2RX1 148.669 -2.398 0.438 -5.472 4.45E-08 5.5E-05 HLA-DQA2 727.189 -2.380 0.706 -3.373 0.000745 0.046041 H1FNT 19.382 -2.370 0.679 -3.489 0.000484 0.035553 HRASLS2 39.108 -2.369 0.675 -3.508 0.000452 0.034045 S100A9 159.310 -2.361 0.645 -3.659 0.000253 0.023819 S1PR4 15.540 -2.359 0.670 -3.522 0.000429 0.032938 SLAMF6 100.331 -2.340 0.547 -4.280 1.87E-05 0.00498 C2CD4B 20.726 -2.338 0.652 -3.588 0.000334 0.028082 GZMH 29.763 -2.327 0.606 -3.843 0.000122 0.015591 DARC 189.956 -2.327 0.559 -4.165 3.11E-05 0.006987 PHYHIP 50.305 -2.315 0.565 -4.094 4.24E-05 0.008263 NOX4 883.637 -2.297 0.620 -3.708 0.000209 0.021571 SELE 94.866 -2.290 0.644 -3.556 0.000376 0.03045 CD7 40.729 -2.275 0.650 -3.498 0.000468 0.034556 KIAA1644 35.883 -2.263 0.574 -3.941 8.10E-05 0.012516 JPH2 477.167 -2.257 0.584 -3.864 0.000112 0.014947 IL21R 53.041 -2.251 0.618 -3.640 0.000273 0.025046 VTRNA2-1 114.946 -2.245 0.618 -3.630 0.000284 0.025232 IL2RB 174.545 -2.244 0.512 -4.380 1.19E-05 0.003867 TTLL6 48.010 -2.237 0.660 -3.389 0.000702 0.044371 FAIM2 207.810 -2.235 0.517 -4.327 1.51E-05 0.00448 SLAMF1 72.570 -2.216 0.614 -3.612 0.000304 0.026202 CTLA4 79.350 -2.214 0.592 -3.743 0.000182 0.019952 GATA5 23.373 -2.206 0.660 -3.344 0.000824 0.049007 C11orf89 30.532 -2.204 0.565 -3.900 9.63E-05 0.01406 CD38 282.647 -2.196 0.495 -4.436 9.14E-06 0.00323 C14orf105 125.856 -2.188 0.547 -4.001 6.32E-05 0.010709 NTRK3 856.651 -2.181 0.636 -3.432 0.0006 0.040052 NKG7 45.510 -2.180 0.502 -4.345 1.39E-05 0.004313 DDC 64.930 -2.167 0.455 -4.766 1.88E-06 0.001109 PLK5 16.833 -2.164 0.618 -3.500 0.000465 0.034435 SLC12A3 43.282 -2.155 0.612 -3.522 0.000428 0.032938 CLNK 44.423 -2.146 0.580 -3.700 0.000216 0.02171 ITK 282.391 -2.144 0.542 -3.955 7.65E-05 0.012042 PYHIN1 98.648 -2.130 0.520 -4.097 4.18E-05 0.008249 GZMK 24.060 -2.117 0.601 -3.525 0.000423 0.03275 ZNF831 78.132 -2.087 0.599 -3.483 0.000496 0.035563 TIGIT 98.624 -2.079 0.415 -5.007 5.52E-07 0.000441 EOMES 81.099 -2.056 0.568 -3.621 0.000293 0.025624 SCML4 55.566 -2.053 0.538 -3.815 0.000136 0.016817 HAVCR1 82.459 -2.052 0.523 -3.927 8.59E-05 0.013039 TRBC2 288.121 -2.047 0.476 -4.300 1.71E-05 0.004745 PMP2 56.963 -2.046 0.535 -3.824 0.000131 0.016413 CFD 109.318 -2.041 0.487 -4.192 2.76E-05 0.006504 ABCD2 141.735 -2.038 0.571 -3.567 0.000361 0.02935 P2RY10 57.600 -2.038 0.551 -3.696 0.000219 0.021811 GPR174 88.756 -2.022 0.561 -3.607 0.00031 0.026485 CD3G 156.483 -2.002 0.518 -3.863 0.000112 0.014947 DNASE1L3 28.300 -1.963 0.563 -3.484 0.000494 0.035563 CCL22 18.250 -1.959 0.527 -3.718 0.000201 0.02132 KLRC1 29.904 -1.947 0.518 -3.758 0.000171 0.01949 TLE6 30.522 -1.944 0.551 -3.530 0.000416 0.032647 RP11-572C15.6 11.774 -1.941 0.497 -3.905 9.42E-05 0.013952 CPA4 118.722 -1.941 0.569 -3.412 0.000644 0.042084 CD247 161.493 -1.932 0.426 -4.538 5.68E-06 0.00251 CCL5 356.212 -1.928 0.487 -3.962 7.45E-05 0.012038 RASGEF1A 162.151 -1.915 0.549 -3.487 0.000489 0.035554 RORB 81.665 -1.911 0.529 -3.615 0.0003 0.025977 KLF2 764.698 -1.901 0.548 -3.469 0.000523 0.036629 SVEP1 2703.610 -1.900 0.544 -3.493 0.000477 0.035144 TRAJ36 9.083 -1.900 0.562 -3.381 0.000723 0.044972 GLTPD2 18.978 -1.895 0.513 -3.693 0.000222 0.021811 RP11-113C12.2 5.911 -1.892 0.549 -3.445 0.000572 0.039273 PRF1 115.974 -1.888 0.412 -4.580 4.66E-06 0.002174 STAP1 28.650 -1.885 0.500 -3.767 0.000165 0.018893 IL18RAP 35.037 -1.858 0.472 -3.933 8.39E-05 0.012894 IL2RG 255.980 -1.855 0.481 -3.860 0.000113 0.015069 VNN2 115.499 -1.838 0.313 -5.874 4.25E-09 8.75E-06 SELL 206.753 -1.837 0.447 -4.111 3.93E-05 0.008162 TRAC 179.227 -1.836 0.497 -3.693 0.000221 0.021811 CD8A 344.018 -1.835 0.505 -3.635 0.000278 0.025085 CACNA1A 347.047 -1.833 0.513 -3.571 0.000356 0.02905 CD3E 327.205 -1.828 0.542 -3.370 0.000752 0.046352 LY9 64.171 -1.823 0.466 -3.916 9.00E-05 0.013485 TNFRSF10C 73.099 -1.811 0.433 -4.185 2.86E-05 0.006667 SLC10A6 24.174 -1.806 0.499 -3.620 0.000294 0.025643 IL1RL1 51.821 -1.799 0.521 -3.451 0.000559 0.038485 FIGF 56.581 -1.792 0.509 -3.519 0.000433 0.033064 CCDC141 274.611 -1.790 0.499 -3.590 0.000331 0.028082 CXCR3 31.864 -1.783 0.513 -3.474 0.000514 0.036291 CD2 188.968 -1.780 0.522 -3.408 0.000654 0.042441 TGM2 5122.602 -1.772 0.496 -3.574 0.000352 0.02891 CCR7 65.763 -1.757 0.422 -4.159 3.20E-05 0.007137 HLA-F 1882.775 -1.756 0.469 -3.748 0.000178 0.019675 CD209 463.939 -1.752 0.458 -3.824 0.000131 0.016413 LDB3 563.365 -1.751 0.505 -3.464 0.000532 0.037032 EGR1 18216.478 -1.740 0.514 -3.383 0.000717 0.04479 IL33 582.798 -1.736 0.511 -3.397 0.000682 0.043546 STAB2 326.224 -1.733 0.498 -3.477 0.000507 0.035915 FASLG 25.156 -1.728 0.513 -3.369 0.000754 0.046358 ITGAD 78.300 -1.725 0.448 -3.855 0.000116 0.015085 SLC17A7 16.814 -1.725 0.500 -3.453 0.000554 0.038287 LCK 97.415 -1.720 0.515 -3.339 0.000842 0.049283 KCNMB1 132.538 -1.715 0.462 -3.713 0.000205 0.021377 LTB 80.933 -1.703 0.510 -3.337 0.000846 0.04932 CYTIP 492.644 -1.702 0.431 -3.947 7.91E-05 0.012373 ITGAL 427.875 -1.698 0.413 -4.109 3.98E-05 0.008162 KIF26A 48.756 -1.690 0.497 -3.401 0.00067 0.04295 CSF2RB 448.384 -1.680 0.421 -3.993 6.52E-05 0.010823 ABLIM3 277.010 -1.674 0.411 -4.076 4.59E-05 0.008576 PLXNB3 122.046 -1.655 0.497 -3.333 0.000859 0.04999 NCF1B 110.895 -1.632 0.377 -4.327 1.51E-05 0.00448 ATP2A3 495.488 -1.628 0.381 -4.270 1.95E-05 0.005078 RASGRP2 377.782 -1.628 0.434 -3.748 0.000178 0.019675 SP140 370.064 -1.620 0.405 -4.002 6.27E-05 0.010709 GEM 427.847 -1.619 0.483 -3.354 0.000796 0.047759 HOXD10 129.316 -1.613 0.449 -3.589 0.000332 0.028082 CCR2 127.565 -1.588 0.462 -3.439 0.000584 0.039512 C22orf34 128.959 -1.583 0.448 -3.531 0.000413 0.032557 MEFV 101.442 -1.575 0.427 -3.690 0.000225 0.021867 FAIM3 117.221 -1.570 0.389 -4.035 5.45E-05 0.009725 LSP1 286.643 -1.543 0.363 -4.250 2.14E-05 0.005448 NIPAL4 51.642 -1.529 0.418 -3.653 0.000259 0.024175 GZMA 70.060 -1.526 0.423 -3.611 0.000305 0.026202 HSPB7 100.210 -1.525 0.425 -3.585 0.000337 0.028169 LTA 8.997 -1.519 0.455 -3.338 0.000843 0.049283 KLHL6 260.690 -1.519 0.404 -3.756 0.000173 0.019561 SLC6A1 112.387 -1.514 0.407 -3.715 0.000203 0.021363 PRR16 51.567 -1.501 0.390 -3.853 0.000117 0.015114 IL15RA 253.633 -1.488 0.399 -3.733 0.000189 0.020394 SERPINF2 127.544 -1.477 0.352 -4.195 2.73E-05 0.006496 ZAP70 81.235 -1.465 0.403 -3.637 0.000276 0.025063 BIRC3 2339.619 -1.450 0.322 -4.498 6.85E-06 0.002822 DERL3 133.072 -1.445 0.431 -3.353 0.000799 0.047866 STAT4 233.474 -1.442 0.420 -3.431 0.000601 0.040052 CD28 93.604 -1.433 0.352 -4.074 4.61E-05 0.008576 CD52 23.755 -1.425 0.424 -3.360 0.000778 0.04717 TNFRSF14 704.697 -1.415 0.417 -3.396 0.000685 0.043546 GVINP1 237.288 -1.413 0.412 -3.433 0.000597 0.040052 GIMAP5 193.168 -1.395 0.340 -4.108 3.99E-05 0.008162 ARRDC5 59.618 -1.388 0.392 -3.541 0.000398 0.03154 IL4R 1027.522 -1.371 0.355 -3.859 0.000114 0.015069 AMICA1 251.160 -1.364 0.368 -3.705 0.000211 0.021571 GIMAP7 203.759 -1.345 0.327 -4.113 3.91E-05 0.008162 NCF1 337.988 -1.329 0.386 -3.444 0.000574 0.039293 ABI3 54.458 -1.314 0.327 -4.019 5.86E-05 0.010198 NOS3 216.349 -1.313 0.388 -3.387 0.000706 0.044413 RAMP3 85.731 -1.312 0.382 -3.439 0.000584 0.039512 PIM2 325.160 -1.302 0.347 -3.749 0.000177 0.019675 APOC1 257.451 -1.287 0.375 -3.432 0.000599 0.040052 ECM1 809.655 -1.268 0.268 -4.737 2.17E-06 0.001247 GPR68 49.592 -1.261 0.370 -3.406 0.000659 0.042611 ARID5A 185.814 -1.257 0.346 -3.638 0.000274 0.025046 FAM65B 479.506 -1.251 0.312 -4.006 6.16E-05 0.010657 PRDM1 1049.081 -1.250 0.303 -4.131 3.62E-05 0.007708 HRNR 8613.319 -1.238 0.348 -3.555 0.000378 0.03045 CTSW 78.135 -1.233 0.350 -3.525 0.000423 0.03275 SELM 269.237 -1.227 0.310 -3.957 7.58E-05 0.012042 SMTN 1246.247 -1.214 0.297 -4.084 4.44E-05 0.008406 NCF4 226.538 -1.157 0.312 -3.714 0.000204 0.021377 HHEX 135.652 -1.115 0.324 -3.441 0.000579 0.039512 PYCARD 97.115 -1.077 0.303 -3.554 0.000379 0.03045 CSRP1 3736.397 -1.066 0.281 -3.797 0.000147 0.017637 SOD2 6723.761 -0.959 0.254 -3.778 0.000158 0.018473 CYP2D6 609.914 -0.951 0.244 -3.892 9.96E-05 0.014157 BEST1 691.657 -0.919 0.272 -3.385 0.000711 0.044533 DUSP22 716.481 -0.557 0.133 -4.198 2.69E-05 0.006462 RASAL2 3136.110 0.477 0.136 3.500 0.000465 0.034435 HDAC1 3319.553 0.487 0.137 3.544 0.000395 0.031458 IFT172 3901.182 0.491 0.145 3.380 0.000724 0.044972 MRPL39 813.944 0.492 0.146 3.366 0.000764 0.046616 KDM5A 15567.388 0.495 0.124 3.995 6.48E-05 0.010823 RDH14 875.265 0.506 0.146 3.466 0.000529 0.036921 PHACTR4 4145.592 0.514 0.153 3.356 0.000792 0.047658 NOL10 2344.642 0.521 0.156 3.349 0.000811 0.048344 DTNB 1475.555 0.522 0.156 3.339 0.00084 0.049283 YIPF4 2338.324 0.565 0.151 3.737 0.000186 0.02025 RBBP4 5581.331 0.577 0.146 3.943 8.03E-05 0.012495 GFPT1 10100.089 0.585 0.164 3.574 0.000352 0.02891 TMED4 1845.613 0.590 0.163 3.619 0.000296 0.025663 YTHDF2 2664.773 0.591 0.166 3.554 0.000379 0.03045 GTF3C2 2229.528 0.602 0.144 4.175 2.98E-05 0.006774 EYA3 2685.329 0.604 0.166 3.636 0.000277 0.025076 CHKA 1390.484 0.607 0.179 3.396 0.000683 0.043546 TXNDC12 1229.038 0.608 0.178 3.413 0.000643 0.042084 CACYBP 1687.203 0.620 0.180 3.439 0.000585 0.039512 WDR35 3760.322 0.624 0.182 3.427 0.00061 0.040381 MRPS14 617.225 0.651 0.153 4.241 2.23E-05 0.005562 GXYLT1 1914.451 0.659 0.184 3.572 0.000355 0.02905 RFWD2 3928.845 0.662 0.154 4.286 1.82E-05 0.004955 DDX50P1 118.389 0.666 0.178 3.741 0.000183 0.02006 COPS5 1197.243 0.668 0.184 3.623 0.000291 0.025543 ATP1A1 12426.634 0.740 0.217 3.409 0.000653 0.042441 DARS2 3417.726 0.750 0.214 3.501 0.000463 0.034435 FARP1 5287.423 0.774 0.208 3.732 0.00019 0.020408 ZDHHC13 1853.469 0.804 0.210 3.820 0.000134 0.016601 RAD21 13482.678 0.807 0.232 3.477 0.000506 0.035915 PANK1 627.409 0.827 0.227 3.645 0.000268 0.024781 TSC22D1 7142.471 0.856 0.246 3.483 0.000496 0.035563 C10orf2 912.482 0.868 0.255 3.404 0.000665 0.042783 FNBP1L 4917.831 0.878 0.232 3.789 0.000151 0.017868 NEDD4L 2268.299 0.929 0.235 3.958 7.56E-05 0.012042 ACTRT3 144.898 0.957 0.233 4.115 3.88E-05 0.008162 GATSL2 356.068 0.978 0.290 3.369 0.000756 0.046378 PLEKHG1 3759.265 0.990 0.255 3.877 0.000106 0.014441 FZD6 5047.077 0.991 0.265 3.734 0.000188 0.020394 MSH2 7960.455 1.004 0.273 3.678 0.000235 0.022567 ELOVL6 598.814 1.008 0.285 3.544 0.000394 0.031458 SLC39A10 4758.011 1.011 0.300 3.373 0.000744 0.046041 RP11-177A2.5 17.264 1.023 0.270 3.790 0.000151 0.017868 ALG1L10P 55.667 1.047 0.306 3.418 0.000631 0.041509 TMCC2 146.958 1.049 0.234 4.490 7.11E-06 0.002882 AJUBA 720.786 1.050 0.285 3.686 0.000228 0.02212 AC079250.1 17.826 1.211 0.327 3.704 0.000212 0.021571 IQCA1 1277.056 1.256 0.366 3.427 0.00061 0.040381 MAPK8IP1 1759.046 1.354 0.333 4.067 4.76E-05 0.008784 FAM218A 220.632 1.361 0.350 3.889 0.000101 0.014214 LEF1 1196.399 1.379 0.377 3.661 0.000252 0.02375 PODXL 6610.859 1.416 0.407 3.484 0.000494 0.035563 WLS 3703.093 1.459 0.357 4.083 4.45E-05 0.008406 CDH2 3749.343 1.579 0.435 3.628 0.000286 0.025232 NOS1AP 834.121 1.641 0.464 3.536 0.000407 0.032139 SKIDA1 275.954 1.646 0.434 3.790 0.00015 0.017868 PLXNA4 1335.504 1.671 0.443 3.770 0.000163 0.018771 POU5F1P6 15.049 1.701 0.439 3.872 0.000108 0.014685 KIF5C 1819.348 1.711 0.371 4.616 3.91E-06 0.002055 GAREML 108.464 1.732 0.511 3.387 0.000708 0.044413 KCNQ3 692.177 1.884 0.434 4.345 1.40E-05 0.004313 MSI1 479.747 1.946 0.398 4.892 1.00E-06 0.0007 MYCN 426.219 1.946 0.531 3.669 0.000244 0.023295 C10orf113 52.553 1.960 0.381 5.139 2.76E-07 0.000273 SCG5 293.361 1.981 0.543 3.645 0.000267 0.024781 DLX5 64.110 2.050 0.565 3.628 0.000286 0.025232 CYYR1 976.575 2.090 0.590 3.543 0.000396 0.031458 GAD1 562.036 2.108 0.425 4.966 6.84E-07 0.000513 NPM1P30 14.999 2.109 0.449 4.698 2.63E-06 0.001444 FBN3 1112.644 2.112 0.624 3.387 0.000706 0.044413 SAMD5 433.141 2.121 0.484 4.384 1.17E-05 0.003844 DACH1 1031.988 2.220 0.536 4.143 3.42E-05 0.007402 RPL21P109 9.582 2.246 0.581 3.866 0.00011 0.014924 IGF2BP3 661.362 2.366 0.703 3.365 0.000765 0.046616 FBXO2 181.835 2.409 0.580 4.153 3.28E-05 0.007177 FZD10 335.150 2.411 0.578 4.175 2.99E-05 0.006774 SIX1 362.055 2.540 0.707 3.594 0.000325 0.027718 KIF1A 3234.896 2.573 0.629 4.091 4.29E-05 0.008283 CASC10 303.084 2.590 0.450 5.758 8.52E-09 1.32E-05 COL2A1 1107.283 2.624 0.732 3.588 0.000334 0.028082 EIF4BP2 14.611 2.851 0.430 6.636 3.23E-11 1.60E-07 FGF17 60.480 3.179 0.860 3.695 0.00022 0.021811 FZD10-AS1 2.536 3.196 0.879 3.634 0.000279 0.025085 CTC-478M6.1 20.665 3.405 0.908 3.749 0.000178 0.019675 ALLC 46.622 3.414 0.876 3.895 9.81E-05 0.01406 RP11-351M16.1 4.146 3.582 1.072 3.341 0.000836 0.049283 IL13RA2 134.568 3.611 1.028 3.513 0.000443 0.033472 IGLON5 25.941 3.819 1.096 3.483 0.000496 0.035563 AC007881.4 4.724 3.871 1.152 3.362 0.000775 0.047078 CTC-512J14.7 7.593 3.957 1.179 3.357 0.000789 0.047608 NKX6-1 70.929 4.118 1.132 3.639 0.000273 0.025046 PAGE2 36.659 4.389 1.089 4.031 5.56E-05 0.00976 TRIM71 260.060 4.476 1.000 4.474 7.67E-06 0.002951 DPYSL5 130.415 4.534 1.061 4.275 1.91E-05 0.00503 ZIC2 540.660 4.978 1.245 4.000 6.35E-05 0.010709 C7orf66 10.901 5.173 1.283 4.033 5.51E-05 0.009725

Supplemental Table 6. Genes differentially represented in PD-1Hi vs PD-1Lo HGSCs.

Gene Symbol Base mean log2FC lfcSE stat p-value p-adj NHLH2 69.4914 19.1287 3.1234 6.1244 9.10E-10 1.94E-05 MUC5AC 113.7705 4.0554 0.6778 5.9832 2.19E-09 2.33E-05 ZNF883 179.5560 -2.3045 0.4500 -5.1215 3.03E-07 0.0021 IGHV4OR15-8 53.5073 5.3028 1.0790 4.9144 8.90E-07 0.0047 ATP10B 310.2138 1.8739 0.3950 4.7437 2.10E-06 0.0074 NLRP4 49.5206 7.7080 1.6238 4.7469 2.07E-06 0.0074 KLHDC7A 43.2931 5.5681 1.1836 4.7045 2.54E-06 0.0077 LGSN 135.7003 -5.8839 1.2819 -4.5901 4.43E-06 0.0086 STMN1 3425.4561 -1.3143 0.2854 -4.6044 4.14E-06 0.0086 LINC01002 1418.7840 1.0566 0.2299 4.5956 4.31E-06 0.0086 HOXC9 37.5329 2.7339 0.5956 4.5902 4.43E-06 0.0086 WNT11 118.2827 -2.1456 0.4824 -4.4481 8.66E-06 0.0154 HOXA9 120.1840 4.2812 0.9753 4.3896 1.14E-05 0.0186 LYSMD2 146.7120 1.2002 0.2763 4.3442 1.40E-05 0.0188 OLFM3 181.7194 4.0841 0.9365 4.3612 1.29E-05 0.0188 NTSR1 54.3541 4.5899 1.0571 4.3421 1.41E-05 0.0188 MYEOV 80.6815 4.1863 0.9749 4.2942 1.75E-05 0.0220 BAI1 170.7663 2.1811 0.5219 4.1789 2.93E-05 0.0346 CASC10 480.2675 -1.8202 0.4432 -4.1070 4.01E-05 0.0407 HIST1H2AC 6182.8544 -1.7084 0.4181 -4.0857 4.40E-05 0.0407 RBM44 115.1710 1.6056 0.3910 4.1064 4.02E-05 0.0407 JPH3 88.9498 3.4161 0.8289 4.1212 3.77E-05 0.0407 ATP1A3 609.3814 3.7878 0.9262 4.0898 4.32E-05 0.0407 ZNF208 14978.2526 -2.4085 0.6055 -3.9776 6.96E-05 0.0494 MSI1 534.4657 -1.6811 0.4198 -4.0044 6.22E-05 0.0494 NUDT5 2021.7281 -0.9046 0.2271 -3.9834 6.79E-05 0.0494 RP11-435B5.4 251.4615 1.0635 0.2670 3.9830 6.80E-05 0.0494 FHAD1 617.1148 1.8722 0.4667 4.0110 6.05E-05 0.0494 PLXNB3 134.6479 2.2534 0.5620 4.0098 6.08E-05 0.0494 RP11-796G6.2 30.9787 2.4166 0.6040 4.0011 6.30E-05 0.0494 CTA-313A17.2 37.1309 2.5092 0.6327 3.9660 7.31E-05 0.0502 ALPL 1515.2816 -1.9226 0.4879 -3.9404 8.14E-05 0.0525 BCAN 117.3246 2.4507 0.6218 3.9414 8.10E-05 0.0525 PEG10 7110.9703 -1.7613 0.4488 -3.9247 8.69E-05 0.0528 SNORD115-44 12.5448 6.9718 1.7742 3.9296 8.51E-05 0.0528 PCDHA13 194.1683 1.9594 0.5032 3.8940 9.86E-05 0.0583 ZNF541 74.4684 3.0079 0.7776 3.8683 0.0001 0.0630 VTA1 2241.3115 -0.6880 0.1786 -3.8529 0.0001 0.0654 MUC7 28.0694 7.4346 1.9382 3.8357 0.0001 0.0683 S100A2 427.2643 3.3110 0.8668 3.8199 0.0001 0.0710 CA8 1207.4834 -3.0282 0.7947 -3.8103 0.0001 0.0720 MARCKSL1 1559.0231 -0.9632 0.2564 -3.7566 0.0002 0.0860 CHGA 193.2897 1.6540 0.4412 3.7486 0.0002 0.0860 PLCH2 194.0921 2.3807 0.6350 3.7493 0.0002 0.0860 CLDN6 311.8419 -3.4392 0.9222 -3.7294 0.0002 0.0869 GUSBP1 1899.8520 0.9838 0.2632 3.7384 0.0002 0.0869 IGF2 8499.1656 4.2912 1.1494 3.7334 0.0002 0.0869 RUNX3 301.6276 1.9160 0.5171 3.7055 0.0002 0.0916 SAGE1 69.4512 5.1967 1.4023 3.7057 0.0002 0.0916 KIAA1456 372.2537 2.3431 0.6338 3.6968 0.0002 0.0917 C9orf66 59.5543 2.5227 0.6827 3.6952 0.0002 0.0917 SLC17A1 15.3598 5.7073 1.5482 3.6865 0.0002 0.0931 OR3A1 67.6582 3.8076 1.0348 3.6796 0.0002 0.0938 GPR111 44.9475 4.0866 1.1136 3.6696 0.0002 0.0940 C4orf17 37.1240 4.5296 1.2342 3.6700 0.0002 0.0940 PYCARD 106.7617 1.1631 0.3183 3.6537 0.0003 0.0976 AJAP1 111.3880 2.1026 0.5766 3.6464 0.0003 0.0976 AC021218.2 39.6748 4.7326 1.2964 3.6507 0.0003 0.0976 CAMK1D 1368.2223 -1.3665 0.3766 -3.6287 0.0003 0.1014 PCDHA7 178.4723 1.6872 0.4657 3.6234 0.0003 0.1014 GSC 32.3465 3.8031 1.0484 3.6276 0.0003 0.1014 TET3 4008.4037 -0.7384 0.2055 -3.5928 0.0003 0.1092 ONECUT1 19.8221 5.2215 1.4518 3.5965 0.0003 0.1092 OR3A4P 37.2784 5.3304 1.4841 3.5917 0.0003 0.1092 LIN28B 106.2010 -7.9316 2.2179 -3.5762 0.0003 0.1108 IGHV3-23 1536.5185 3.0725 0.8584 3.5792 0.0003 0.1108 ZIC3 70.8582 5.8572 1.6379 3.5760 0.0003 0.1108 HPN 768.8330 -3.0739 0.8670 -3.5455 0.0004 0.1226 OR4D5 19.4352 5.5664 1.5740 3.5365 0.0004 0.1251 IL36RN 20.3022 4.9496 1.4098 3.5109 0.0004 0.1358 PLCE1 6528.1664 -1.4780 0.4218 -3.5044 0.0005 0.1362 MPP3 304.0780 -0.8249 0.2355 -3.5025 0.0005 0.1362 HOXA10 100.3255 2.6644 0.7632 3.4910 0.0005 0.1403 MYBPC2 65.2328 2.9423 0.8460 3.4778 0.0005 0.1454 PAX2 2285.8639 -6.6293 1.9164 -3.4592 0.0005 0.1517 NCAN 36.9247 3.9038 1.1283 3.4599 0.0005 0.1517 ZNF146 5161.9590 -1.0117 0.2932 -3.4504 0.0006 0.1527 TMCO5A 59.0145 4.1685 1.2074 3.4525 0.0006 0.1527 ZNF829 669.3248 -1.1505 0.3368 -3.4159 0.0006 0.1675 STK38 2629.7064 -0.7744 0.2265 -3.4187 0.0006 0.1675 FCRL6 116.7892 1.5716 0.4606 3.4118 0.0006 0.1675 DOC2B 221.1965 2.2632 0.6632 3.4127 0.0006 0.1675 CLDND2 34.6486 1.2226 0.3594 3.4019 0.0007 0.1716 SH2D3A 287.1695 1.2624 0.3719 3.3944 0.0007 0.1729 GPR123 47.3970 4.9996 1.4734 3.3933 0.0007 0.1729 IFITM9P 26.1999 3.5530 1.0486 3.3885 0.0007 0.1739 DSCR8 92.2491 -8.5263 2.5306 -3.3693 0.0008 0.1787 SYNGAP1 5022.2457 -0.8199 0.2431 -3.3732 0.0007 0.1787 TMEM171 34.2569 3.1714 0.9415 3.3685 0.0008 0.1787 HPGD 1827.7135 3.7289 1.1058 3.3723 0.0007 0.1787 RP5-828H9.1 16.8295 4.4299 1.3168 3.3641 0.0008 0.1796 B4GALNT4 800.5574 -1.0449 0.3114 -3.3549 0.0008 0.1836 ZNF736 2928.3861 -0.6171 0.1848 -3.3387 0.0008 0.1882 SNORD14A 47.4817 1.0485 0.3151 3.3270 0.0009 0.1882 MIR4435-1HG 62.3454 1.3516 0.4045 3.3412 0.0008 0.1882 SNORA74B 8086.5610 1.5497 0.4661 3.3245 0.0009 0.1882 PCBP3 94.1461 2.3281 0.7015 3.3187 0.0009 0.1882 FAM153A 111.3735 2.4461 0.7339 3.3328 0.0009 0.1882 SCN3A 687.6999 2.5427 0.7632 3.3315 0.0009 0.1882 ATCAY 43.5471 3.3819 1.0194 3.3176 0.0009 0.1882 TNN 74.8174 3.9528 1.1919 3.3163 0.0009 0.1882 OR3A2 59.5845 5.0612 1.5272 3.3140 0.0009 0.1882 GC 22.0229 5.2995 1.5888 3.3356 0.0009 0.1882 C1orf94 29.7693 5.8338 1.7575 3.3193 0.0009 0.1882 TCTEX1D2 144.7175 -1.1013 0.3332 -3.3050 0.0009 0.1925 SP5 34.8966 -2.8439 0.8657 -3.2850 0.0010 0.2021 ZBTB12 231.1530 -1.1273 0.3436 -3.2807 0.0010 0.2021 TUBA4A 683.8484 1.3980 0.4261 3.2809 0.0010 0.2021 FRMD1 31.5523 3.0951 0.9445 3.2768 0.0010 0.2021 VSTM1 11.7157 4.4359 1.3516 3.2819 0.0010 0.2021 RAB44 12.1499 5.2783 1.6114 3.2756 0.0011 0.2021 LDHB 13193.7114 -1.3293 0.4070 -3.2658 0.0011 0.2074 GALNT3 8173.9522 -1.6280 0.4996 -3.2584 0.0011 0.2091 RNF43 1433.1559 -0.9958 0.3055 -3.2593 0.0011 0.2091 ETNK1 7564.7370 -0.7142 0.2198 -3.2496 0.0012 0.2139 GMNN 437.0719 -0.9577 0.2966 -3.2288 0.0012 0.2261 TRIM51EP 11.8839 6.3288 1.9601 3.2288 0.0012 0.2261 RAC3 123.4629 -1.1525 0.3599 -3.2026 0.0014 0.2273 GATSL2 409.9843 -1.0611 0.3339 -3.1778 0.0015 0.2273 RBM17 4854.9607 -0.9795 0.3084 -3.1765 0.0015 0.2273 JAK3 1260.0155 1.1749 0.3684 3.1893 0.0014 0.2273 PDGFA 780.4220 1.3268 0.4171 3.1812 0.0015 0.2273 PRR16 51.8394 1.4672 0.4612 3.1814 0.0015 0.2273 ANKRD22 131.0140 1.9043 0.5959 3.1957 0.0014 0.2273 RAB33A 49.1727 1.9467 0.6118 3.1820 0.0015 0.2273 TMEM74B 53.1404 1.9693 0.6162 3.1959 0.0014 0.2273 LRG1 116.4959 2.0718 0.6468 3.2031 0.0014 0.2273 CR1L 86.5441 2.2636 0.7104 3.1863 0.0014 0.2273 IFNG 25.6840 2.4236 0.7560 3.2059 0.0013 0.2273 CAMK2B 124.1143 2.5675 0.8009 3.2058 0.0013 0.2273 SIGLEC22P 10.5887 2.7488 0.8531 3.2220 0.0013 0.2273 KLHL1 43.3042 3.1294 0.9844 3.1791 0.0015 0.2273 TIFAB 14.8193 3.2006 0.9952 3.2161 0.0013 0.2273 FRMD7 42.7698 3.3966 1.0669 3.1835 0.0015 0.2273 PAEP 129.7957 3.5586 1.1139 3.1946 0.0014 0.2273 CTD-2503O16.3 10.1900 3.6683 1.1410 3.2151 0.0013 0.2273 OR4D1 13.6014 5.2659 1.6513 3.1890 0.0014 0.2273 SERPINB10 30.2175 5.3088 1.6572 3.2034 0.0014 0.2273 OR1F1 21.2260 5.4687 1.7171 3.1849 0.0014 0.2273 MMP26 46.4842 9.6765 3.0472 3.1756 0.0015 0.2273 SMDT1 319.7681 1.1068 0.3500 3.1620 0.0016 0.2364 CRYGB 49.7034 -4.3291 1.3720 -3.1554 0.0016 0.2380 HTR3A 881.8612 2.5553 0.8095 3.1567 0.0016 0.2380 FRG2 19.3985 6.2646 1.9862 3.1540 0.0016 0.2380 OTUD7A 118.9007 1.4738 0.4680 3.1492 0.0016 0.2402 VN1R5 16.5432 2.9263 0.9308 3.1439 0.0017 0.2409 GPR55 26.0922 3.0595 0.9736 3.1425 0.0017 0.2409 TNFSF11 29.0436 3.1812 1.0117 3.1445 0.0017 0.2409 AZGP1 176.3721 -3.1542 1.0050 -3.1384 0.0017 0.2426 SOX11 217.2216 -4.3570 1.3922 -3.1295 0.0018 0.2482 DPP10 737.8468 -4.0006 1.2815 -3.1219 0.0018 0.2482 FBN2 5491.5618 -2.3895 0.7679 -3.1117 0.0019 0.2482 GAREML 137.3780 -1.4993 0.4825 -3.1075 0.0019 0.2482 DDAH2 1359.7377 -1.1666 0.3753 -3.1085 0.0019 0.2482 KRCC1 2047.3083 -0.8330 0.2684 -3.1038 0.0019 0.2482 HERC3 1674.7696 0.9342 0.3001 3.1129 0.0019 0.2482 CCDC73 152.2302 1.6004 0.5120 3.1258 0.0018 0.2482 PCDHAC1 106.2033 1.6437 0.5296 3.1035 0.0019 0.2482 CTGLF10P 183.2115 1.8782 0.6040 3.1099 0.0019 0.2482 RP11-830F9.6 35.4251 2.0618 0.6616 3.1164 0.0018 0.2482 MEI4 84.5876 3.5653 1.1402 3.1268 0.0018 0.2482 MUC17 346.9010 4.2241 1.3556 3.1160 0.0018 0.2482 SLC13A1 65.8360 4.7486 1.5287 3.1063 0.0019 0.2482 OOEP 15.6289 5.0934 1.6399 3.1059 0.0019 0.2482 ALX4 81.1574 2.2200 0.7159 3.1011 0.0019 0.2483 PRAMEF4 14.4597 5.8881 1.8995 3.0998 0.0019 0.2483 VAV1 340.1500 1.4539 0.4697 3.0952 0.0020 0.2506 ZNF80 20.8866 2.9916 0.9679 3.0908 0.0020 0.2528 BCL3 489.4379 0.9684 0.3151 3.0738 0.0021 0.2616 TNC 3582.8625 2.2678 0.7385 3.0709 0.0021 0.2616 PCDHB1 73.9413 2.3846 0.7771 3.0685 0.0022 0.2616 FCN2 19.0980 2.8313 0.9223 3.0700 0.0021 0.2616 IGLV6-57 58.6881 2.9883 0.9734 3.0698 0.0021 0.2616 GABRB1 34.9553 3.4723 1.1305 3.0716 0.0021 0.2616 IGHV3OR16-7 12.4233 5.7652 1.8739 3.0765 0.0021 0.2616 CCL22 31.7873 2.1246 0.6937 3.0625 0.0022 0.2639 OR2F1 20.0693 3.5712 1.1658 3.0634 0.0022 0.2639 DHTKD1 2736.7384 -0.7479 0.2446 -3.0572 0.0022 0.2668 NSG2 27.2987 3.7971 1.2426 3.0558 0.0022 0.2668 CD6 190.0187 1.3928 0.4564 3.0519 0.0023 0.2673 AVPR1B 57.8566 2.3037 0.7546 3.0527 0.0023 0.2673 HMGA1 4480.8336 -1.7026 0.5600 -3.0404 0.0024 0.2688 CDCA7L 1685.0160 -1.0937 0.3594 -3.0434 0.0023 0.2688 ZNF605 2504.1272 -0.9488 0.3122 -3.0388 0.0024 0.2688 ZNF518A 4152.2111 -0.9352 0.3069 -3.0475 0.0023 0.2688 PPP1R8 1587.4804 -0.5060 0.1661 -3.0466 0.0023 0.2688 CD5 265.7572 1.3376 0.4397 3.0422 0.0023 0.2688 CCL26 45.4431 4.1772 1.3738 3.0405 0.0024 0.2688 ANKS1A 3720.6368 -1.0520 0.3474 -3.0284 0.0025 0.2755 MUC5B 26145.5998 3.4238 1.1306 3.0282 0.0025 0.2755 PCDHA10 546.3048 1.9669 0.6499 3.0266 0.0025 0.2755 CEP89 1848.3794 -1.1690 0.3865 -3.0245 0.0025 0.2760 IDO2 30.3121 3.0491 1.0087 3.0228 0.0025 0.2762 PTAFR 374.5818 1.2152 0.4033 3.0130 0.0026 0.2795 OR51E2 50.2132 2.7273 0.9049 3.0140 0.0026 0.2795 TBX4 39.6907 2.8305 0.9393 3.0134 0.0026 0.2795 SNORD115-9 14.9046 6.0569 2.0076 3.0170 0.0026 0.2795 PIGN 3832.4644 -0.5510 0.1832 -3.0077 0.0026 0.2815 RP11-351I21.6 1613.8250 1.8366 0.6106 3.0081 0.0026 0.2815 HIST1H2BD 5145.7832 -1.5089 0.5020 -3.0060 0.0026 0.2816 OR8G2P 27.0487 -6.3275 2.1120 -2.9959 0.0027 0.2853 PAGE2 69.5588 -4.3061 1.4360 -2.9986 0.0027 0.2853 RP11-706O15.7 34.2766 -3.8322 1.2788 -2.9967 0.0027 0.2853 RP11-599J14.2 14.9833 -1.8317 0.6141 -2.9828 0.0029 0.2853 STK38L 5230.1264 -0.8457 0.2834 -2.9842 0.0028 0.2853 CRAT 472.8709 0.6925 0.2319 2.9856 0.0028 0.2853 ST3GAL1 1599.4714 0.9641 0.3221 2.9930 0.0028 0.2853 CXCL9 1647.5461 2.1907 0.7329 2.9891 0.0028 0.2853 IGHV1OR15-3 44.6686 2.5291 0.8464 2.9880 0.0028 0.2853 SHISA3 48.2644 3.1130 1.0409 2.9907 0.0028 0.2853 TMEM179 29.2772 3.8059 1.2740 2.9873 0.0028 0.2853 TCHHL1 39.5529 4.4120 1.4757 2.9898 0.0028 0.2853 C4orf40 14.4635 6.2959 2.1089 2.9854 0.0028 0.2853 RIN3 595.2456 0.8980 0.3015 2.9788 0.0029 0.2877 RP4-791C19.1 18.0960 3.7653 1.2652 2.9761 0.0029 0.2890 CLCA3P 54.6115 -1.8955 0.6389 -2.9670 0.0030 0.2936 BEST1 573.2626 1.1185 0.3770 2.9669 0.0030 0.2936 PRSS38 14.5064 2.5422 0.8567 2.9676 0.0030 0.2936 LINC00665 85.0522 -1.1253 0.3798 -2.9630 0.0030 0.2947 APCDD1L 41.1692 1.5121 0.5101 2.9641 0.0030 0.2947 PANK1 872.7817 -0.7717 0.2606 -2.9610 0.0031 0.2952 CNTN4 383.6710 1.7481 0.5909 2.9585 0.0031 0.2963 TRIM71 200.9372 -3.7328 1.2660 -2.9484 0.0032 0.3034 IGLC2 3547.5329 2.9733 1.0080 2.9496 0.0032 0.3034 PDE6A 220.4973 1.1845 0.4022 2.9453 0.0032 0.3047 NRSN1 70.8590 2.0913 0.7103 2.9444 0.0032 0.3047 ZNF117 24880.8693 -1.2605 0.4286 -2.9412 0.0033 0.3065 ANKRD33 80.4350 -6.1564 2.1220 -2.9012 0.0037 0.3104 GAB4 25.9628 -5.5313 1.9159 -2.8870 0.0039 0.3104 POTEG 2192.7160 -3.7169 1.2867 -2.8887 0.0039 0.3104 PDE6G 92.4643 -2.1625 0.7386 -2.9277 0.0034 0.3104 MRPS18AP1 14.5984 -1.9156 0.6572 -2.9148 0.0036 0.3104 FOXQ1 799.0120 -1.6198 0.5594 -2.8958 0.0038 0.3104 AC139452.2 89.0257 -1.4627 0.5023 -2.9122 0.0036 0.3104 PTN 530.3993 -1.3773 0.4771 -2.8869 0.0039 0.3104 GTPBP4 3070.2978 -1.1724 0.4019 -2.9174 0.0035 0.3104 POLR2I 148.6835 -1.0340 0.3577 -2.8905 0.0038 0.3104 ZNF382 979.8987 -0.9959 0.3420 -2.9124 0.0036 0.3104 TBC1D24 862.8174 -0.9470 0.3278 -2.8893 0.0039 0.3104 BTF3L4 2056.9128 -0.9327 0.3197 -2.9173 0.0035 0.3104 FNBP1L 6621.4058 -0.8712 0.2979 -2.9242 0.0035 0.3104 FAM211A 258.5832 -0.7787 0.2678 -2.9080 0.0036 0.3104 CCDC138 798.5979 -0.6950 0.2400 -2.8953 0.0038 0.3104 TRADD 187.7681 0.9579 0.3303 2.9000 0.0037 0.3104 SARDH 194.3485 1.0295 0.3556 2.8952 0.0038 0.3104 BMS1P8 46.2018 1.3590 0.4680 2.9041 0.0037 0.3104 PCDHA6 265.9719 1.5953 0.5514 2.8933 0.0038 0.3104 ODF3B 417.4459 1.6040 0.5522 2.9046 0.0037 0.3104 RP11-1094M14.9 37.1909 1.7306 0.5976 2.8962 0.0038 0.3104 ATP4B 32.0037 1.9297 0.6642 2.9055 0.0037 0.3104 CRYBB2 30.8774 2.0258 0.6954 2.9132 0.0036 0.3104 RPS15AP24 23.0868 2.0404 0.7008 2.9114 0.0036 0.3104 TRPM6 266.4419 2.1153 0.7271 2.9094 0.0036 0.3104 CTD-3088G3.8 23.7747 2.1759 0.7522 2.8927 0.0038 0.3104 OR1N2 43.3222 2.4922 0.8511 2.9282 0.0034 0.3104 SHOX2 62.1983 2.6928 0.9329 2.8866 0.0039 0.3104 ASIC2 52.5614 2.8544 0.9753 2.9267 0.0034 0.3104 KLRC2 50.9853 2.8550 0.9761 2.9250 0.0034 0.3104 IGLV3-1 509.0766 2.9358 1.0096 2.9079 0.0036 0.3104 C9orf171 45.2028 2.9948 1.0287 2.9113 0.0036 0.3104 PITX2 72.6956 3.2115 1.1038 2.9094 0.0036 0.3104 PRSS41 15.1552 3.2809 1.1349 2.8910 0.0038 0.3104 CLLU1 57.2379 3.3152 1.1463 2.8921 0.0038 0.3104 C22orf42 18.6836 3.3807 1.1660 2.8993 0.0037 0.3104 FSCB 29.3907 3.4234 1.1696 2.9270 0.0034 0.3104 SHH 33.6442 3.5860 1.2371 2.8987 0.0037 0.3104 TMEM132D 40.0806 4.1701 1.4300 2.9161 0.0035 0.3104 GOLGA8J 228.0546 1.4678 0.5107 2.8739 0.0041 0.3184 LMTK3 150.7373 1.6211 0.5640 2.8742 0.0041 0.3184 PHYHIPL 335.1132 2.1151 0.7356 2.8753 0.0040 0.3184 ARL14 15.0442 2.7217 0.9469 2.8743 0.0040 0.3184 CSMD3 475.4606 3.0617 1.0659 2.8723 0.0041 0.3188 GUCY1B2 117.9602 -1.8103 0.6320 -2.8645 0.0042 0.3220 RAC2 351.4699 1.5255 0.5323 2.8658 0.0042 0.3220 ACY3 27.9218 2.3941 0.8355 2.8653 0.0042 0.3220 GPIHBP1 775.7308 2.6064 0.9092 2.8666 0.0041 0.3220 GBP5 2028.0095 1.4934 0.5216 2.8633 0.0042 0.3220 MMP1 64.2596 -3.8050 1.3308 -2.8593 0.0042 0.3227 LAMP5 411.5629 -1.8309 0.6411 -2.8561 0.0043 0.3227 ADAMTS9 4485.5950 -1.4462 0.5073 -2.8508 0.0044 0.3227 HN1L 2074.2931 -1.1241 0.3934 -2.8576 0.0043 0.3227 MALAT1 602265.5879 0.6047 0.2116 2.8580 0.0043 0.3227 ALPK3 380.9310 1.1083 0.3882 2.8553 0.0043 0.3227 MYO7A 788.2892 1.3321 0.4671 2.8517 0.0043 0.3227 FAM46C 1160.0763 1.3602 0.4769 2.8521 0.0043 0.3227 PHOSPHO1 55.6704 1.8186 0.6380 2.8504 0.0044 0.3227 SEL1L2 30.2818 2.5943 0.9093 2.8530 0.0043 0.3227 TMCO2 10.5198 3.6953 1.2955 2.8524 0.0043 0.3227 COL9A2 1747.0100 -1.9170 0.6728 -2.8491 0.0044 0.3228 SFTPD 93.4991 2.0227 0.7105 2.8468 0.0044 0.3240 PTCD3 6915.4379 -0.6453 0.2270 -2.8430 0.0045 0.3262 IDO1 580.5329 1.8369 0.6465 2.8413 0.0045 0.3262 NYAP2 70.5872 3.0114 1.0602 2.8403 0.0045 0.3262 PDE6H 11.9801 4.1606 1.4647 2.8406 0.0045 0.3262 SLC9A3 58.8528 1.3743 0.4843 2.8378 0.0045 0.3265 LILRB3 45.2722 1.8938 0.6671 2.8387 0.0045 0.3265 MAP3K7CL 337.3559 1.0686 0.3774 2.8315 0.0046 0.3319 TGIF2LX 48.6944 -8.4456 3.0064 -2.8093 0.0050 0.3353 ZNF679 127.6625 -5.1678 1.8335 -2.8186 0.0048 0.3353 DRD4 181.7768 -1.2684 0.4488 -2.8263 0.0047 0.3353 SPON2 353.3445 -1.2101 0.4297 -2.8161 0.0049 0.3353 OPN3 721.0401 -1.1444 0.4058 -2.8202 0.0048 0.3353 WDR54 551.2004 -0.7887 0.2798 -2.8184 0.0048 0.3353 KIN 1127.9784 -0.7734 0.2740 -2.8230 0.0048 0.3353 SERBP1 7207.7140 -0.7353 0.2609 -2.8188 0.0048 0.3353 CCDC18 1634.2791 -0.6394 0.2270 -2.8163 0.0049 0.3353 SASS6 1198.6893 -0.5142 0.1820 -2.8248 0.0047 0.3353 CLIP2 810.1392 0.9161 0.3261 2.8093 0.0050 0.3353 SDCBP2 85.8474 1.2445 0.4433 2.8074 0.0050 0.3353 PCDHAC2 75.0579 1.5735 0.5601 2.8092 0.0050 0.3353 RBFOX3 39.3966 2.2407 0.7945 2.8204 0.0048 0.3353 GPC5 109.6976 2.3895 0.8502 2.8104 0.0049 0.3353 SLC17A3 45.0380 2.6548 0.9443 2.8113 0.0049 0.3353 PIGR 132.9582 2.7870 0.9877 2.8218 0.0048 0.3353 PTCRA 11.6558 3.4819 1.2369 2.8151 0.0049 0.3353 OR2F2 14.6326 3.5021 1.2475 2.8073 0.0050 0.3353 KRT40 15.7987 3.7606 1.3390 2.8084 0.0050 0.3353 ANKRD27 4585.7029 -1.2941 0.4617 -2.8029 0.0051 0.3378 AC131097.4 49.8021 0.7116 0.2538 2.8034 0.0051 0.3378 RP11-958N24.2 331.5824 -2.8530 1.0194 -2.7987 0.0051 0.3380 RP11-121L10.3 106.8283 -2.2776 0.8133 -2.8004 0.0051 0.3380 ERV3-1 2492.2197 -1.2724 0.4550 -2.7966 0.0052 0.3380 SLC6A9 1203.9243 -1.1671 0.4172 -2.7974 0.0052 0.3380 AC002365.1 34.9160 1.8596 0.6643 2.7992 0.0051 0.3380 TNFRSF18 24.7281 2.8148 1.0068 2.7957 0.0052 0.3380 F13B 13.2673 3.2155 1.1479 2.8012 0.0051 0.3380 ENDOU 111.8659 1.1584 0.4146 2.7941 0.0052 0.3387 EMILIN2 729.3847 1.2430 0.4457 2.7892 0.0053 0.3417 RP11-351I21.7 1110.4978 1.8298 0.6558 2.7901 0.0053 0.3417 CACYBP 1975.6180 -0.7633 0.2740 -2.7857 0.0053 0.3429 ZSCAN12 908.8506 -0.6314 0.2268 -2.7837 0.0054 0.3429 TCEANC 130.8989 0.8123 0.2920 2.7822 0.0054 0.3429 GNRHR2 38.2635 1.1058 0.3972 2.7840 0.0054 0.3429 ALDOB 77.6609 1.7650 0.6343 2.7828 0.0054 0.3429 ADRA1A 59.5954 2.6870 0.9654 2.7832 0.0054 0.3429 NID2 3498.4124 -1.1599 0.4172 -2.7804 0.0054 0.3438 CTD-2325A15.3 309.1812 -3.4881 1.2558 -2.7775 0.0055 0.3449 GNRHR 604.8888 -0.7939 0.2858 -2.7782 0.0055 0.3449 GDF10 26.9783 -3.7691 1.3596 -2.7723 0.0056 0.3476 LRRTM1 474.9465 -2.7357 0.9867 -2.7725 0.0056 0.3476 PASD1 15.6904 4.9488 1.7853 2.7720 0.0056 0.3476 RP13-644M16.1 15.3770 2.6707 0.9640 2.7705 0.0056 0.3482 UTS2 30.4496 2.5436 0.9192 2.7673 0.0057 0.3507 POTEM 895.1896 -5.0417 1.8247 -2.7630 0.0057 0.3540 MTL5 655.8276 -1.0635 0.3851 -2.7613 0.0058 0.3540 RAB19 107.8969 1.4013 0.5073 2.7622 0.0057 0.3540 LARP4B 7686.3339 -0.9063 0.3287 -2.7574 0.0058 0.3573 OR7E5P 16.4578 -5.5623 2.0204 -2.7530 0.0059 0.3580 TNFRSF14 903.9426 1.3353 0.4849 2.7538 0.0059 0.3580 LCA10 16.0997 2.5705 0.9333 2.7541 0.0059 0.3580 GSG1L 26.1400 3.5975 1.3064 2.7537 0.0059 0.3580 PTK2B 1598.2278 1.1402 0.4145 2.7508 0.0059 0.3584 A4GNT 32.2302 2.0062 0.7292 2.7513 0.0059 0.3584 TMEM151A 12.1476 2.7862 1.0135 2.7492 0.0060 0.3591 VAC14-AS1 48.5960 1.0692 0.3897 2.7436 0.0061 0.3622 FAM3D 24.2943 2.4756 0.9021 2.7442 0.0061 0.3622 GABRA2 128.4238 3.7176 1.3545 2.7447 0.0061 0.3622 AMBN 12.8456 4.7194 1.7219 2.7408 0.0061 0.3643 ACOT9 946.1691 0.4919 0.1797 2.7376 0.0062 0.3658 RP11-503N18.1 48.7336 2.8013 1.0236 2.7368 0.0062 0.3658 CIDEA 9.5524 3.7584 1.3729 2.7377 0.0062 0.3658 HTR1F 122.7534 1.3600 0.4974 2.7340 0.0063 0.3658 PTGIR 37.6328 1.7327 0.6336 2.7347 0.0062 0.3658 OXCT2 19.7946 2.0687 0.7567 2.7341 0.0063 0.3658 IGF2BP3 797.9437 -2.8332 1.0369 -2.7324 0.0063 0.3666 MRPL33 1941.7087 -0.5069 0.1857 -2.7298 0.0063 0.3673 RILP 90.5022 1.2191 0.4473 2.7258 0.0064 0.3673 GK 1366.2319 1.2307 0.4516 2.7254 0.0064 0.3673 FER1L4 425.7683 1.3419 0.4920 2.7274 0.0064 0.3673 IL2RB 273.5712 1.6528 0.6068 2.7240 0.0065 0.3673 DMBT1 348.9561 2.3401 0.8577 2.7283 0.0064 0.3673 RIMBP3 29.3396 2.4629 0.9034 2.7261 0.0064 0.3673 IL26 22.3350 3.0478 1.1190 2.7237 0.0065 0.3673 AFP 31.2702 3.1300 1.1478 2.7269 0.0064 0.3673 FMOD 1713.3255 -1.5341 0.5639 -2.7204 0.0065 0.3680 SLCO1C1 105.9240 2.6789 0.9846 2.7209 0.0065 0.3680 GDF6 78.6324 2.7968 1.0274 2.7221 0.0065 0.3680 CLTCL1 453.7735 0.8547 0.3145 2.7173 0.0066 0.3686 GRIN2D 178.6111 1.8523 0.6816 2.7178 0.0066 0.3686 TLL1 630.3400 2.2017 0.8099 2.7185 0.0066 0.3686 NUCKS1 24375.1051 -0.5684 0.2093 -2.7156 0.0066 0.3695 ZRSR2 1074.9808 0.4378 0.1613 2.7137 0.0067 0.3700 RP13-383K5.4 12.3296 1.8535 0.6831 2.7134 0.0067 0.3700 LPAR2 396.4359 -0.8850 0.3263 -2.7125 0.0067 0.3700 DNAJA1 4369.5370 -0.9032 0.3336 -2.7079 0.0068 0.3705 RASGRP1 1426.2868 0.7257 0.2679 2.7085 0.0068 0.3705 PCDHA8 142.8965 1.2824 0.4731 2.7107 0.0067 0.3705 RPS3AP29 10.7138 2.3795 0.8787 2.7078 0.0068 0.3705 ADCYAP1 31.5655 3.5945 1.3267 2.7093 0.0067 0.3705 KIRREL2 51.8771 3.1419 1.1608 2.7066 0.0068 0.3709 DNM1P33 9.7834 2.3998 0.8881 2.7022 0.0069 0.3749 SLC43A2 733.4910 0.6938 0.2571 2.6989 0.0070 0.3759 DOCK8 3372.1074 1.0191 0.3779 2.6966 0.0070 0.3759 SLFN12L 330.0788 1.1107 0.4119 2.6962 0.0070 0.3759 CHRDL2 62.7784 1.7476 0.6481 2.6965 0.0070 0.3759 KCNK9 24.5088 2.0246 0.7501 2.6992 0.0070 0.3759 TMPRSS11B 22.1095 4.9179 1.8227 2.6981 0.0070 0.3759 UMODL1 179.3130 -3.4921 1.2966 -2.6933 0.0071 0.3764 SPAG4 412.7067 1.3019 0.4832 2.6941 0.0071 0.3764 MAPK8IP2 173.7278 1.3637 0.5063 2.6934 0.0071 0.3764 DNASE1L1 119.2419 0.7846 0.2915 2.6914 0.0071 0.3767 LENG1 104.2373 0.7962 0.2958 2.6921 0.0071 0.3767 IGHV1-2 238.8543 2.9949 1.1138 2.6889 0.0072 0.3785 PCMTD2 4335.0574 -0.4911 0.1827 -2.6879 0.0072 0.3788 URI1 8534.0130 -1.1161 0.4156 -2.6858 0.0072 0.3801 PCDH8 29.8757 3.8557 1.4367 2.6838 0.0073 0.3816 GPR64 2521.5216 -1.1492 0.4290 -2.6786 0.0074 0.3837 THBS4 587.6177 -1.0673 0.3984 -2.6793 0.0074 0.3837 CDC123 2275.1951 -1.0606 0.3957 -2.6802 0.0074 0.3837 CEACAM7 32.1648 4.2454 1.5840 2.6801 0.0074 0.3837 HTR6 19.7227 2.5089 0.9382 2.6742 0.0075 0.3879 RP11-79L9.2 149.9398 0.9963 0.3728 2.6724 0.0075 0.3880 ACHE 66.4160 1.9422 0.7265 2.6732 0.0075 0.3880 RPL21P1 66.1949 1.0053 0.3769 2.6670 0.0077 0.3933 PPIL1 777.3866 -0.8543 0.3207 -2.6640 0.0077 0.3959 NOTUM 64.0570 -4.2044 1.5796 -2.6617 0.0078 0.3961 JUN 6099.7942 -0.7009 0.2636 -2.6590 0.0078 0.3961 TCEANC2 303.5293 -0.6807 0.2559 -2.6599 0.0078 0.3961 HMGN2P20 102.1489 0.8082 0.3035 2.6627 0.0078 0.3961 AC073869.20 22.3074 3.0006 1.1283 2.6594 0.0078 0.3961 NEUROG2 12.7124 6.4812 2.4371 2.6593 0.0078 0.3961 SRPK1 3936.6635 -0.7525 0.2832 -2.6573 0.0079 0.3970 MSRA 350.5852 0.8903 0.3352 2.6559 0.0079 0.3970 PRPS1L1 9.3439 5.6297 2.1194 2.6563 0.0079 0.3970 PPFIA3 216.1809 1.4918 0.5619 2.6548 0.0079 0.3973 SH3BGRL2 1280.1295 -1.0569 0.3987 -2.6511 0.0080 0.3988 PHACTR2P1 11.2156 1.7399 0.6565 2.6504 0.0080 0.3988 LAMB4 81.8843 2.3465 0.8851 2.6512 0.0080 0.3988 SLC1A6 28.2172 4.2022 1.5842 2.6526 0.0080 0.3988 OR9A3P 18.1405 -1.4918 0.5633 -2.6482 0.0081 0.3995 C19orf35 15.6936 1.7773 0.6711 2.6483 0.0081 0.3995 RP11-126O22.1 20.0128 -5.7066 2.1600 -2.6420 0.0082 0.4054 NOTCH3 7602.8605 -1.1712 0.4435 -2.6409 0.0083 0.4054 AMPD1 47.1118 2.6449 1.0014 2.6412 0.0083 0.4054 HSPA8P1 14.4439 1.5302 0.5800 2.6381 0.0083 0.4079 C2orf70 35.8912 2.1652 0.8212 2.6366 0.0084 0.4087 RP11-490K7.4 29.3639 -0.9217 0.3498 -2.6352 0.0084 0.4095 TAS2R38 21.6446 -2.7967 1.0619 -2.6336 0.0084 0.4104 CCDC146 3533.9469 -1.3111 0.4980 -2.6326 0.0085 0.4107 USP6NL 3581.6254 -0.8452 0.3213 -2.6304 0.0085 0.4115 GPBAR1 52.3382 1.2552 0.4771 2.6308 0.0085 0.4115 S100A3 21.7117 1.7252 0.6561 2.6296 0.0085 0.4115 RGS9BP 36.9162 -3.7863 1.4403 -2.6287 0.0086 0.4117 CDH16 104.6416 3.7578 1.4305 2.6269 0.0086 0.4129 TMPRSS11D 480.6060 -1.1383 0.4337 -2.6244 0.0087 0.4143 SDS 100.3588 1.0544 0.4019 2.6235 0.0087 0.4143 CTD-2062F14.2 19.9188 1.6087 0.6131 2.6240 0.0087 0.4143 KRT12 54.4014 1.7169 0.6547 2.6226 0.0087 0.4145 BST2 2807.9788 1.2006 0.4590 2.6158 0.0089 0.4215 GPR171 356.8361 1.5304 0.5852 2.6154 0.0089 0.4215 AP001597.1 11.1523 -2.8857 1.1047 -2.6123 0.0090 0.4220 MYCL 1290.7185 -1.9193 0.7348 -2.6119 0.0090 0.4220 CXCL13 405.9579 2.6000 0.9946 2.6140 0.0089 0.4220 HTR4 24.0410 4.3300 1.6573 2.6127 0.0090 0.4220 CCR9 38.4589 2.3428 0.8975 2.6102 0.0090 0.4225 SPACA7 15.4673 5.1629 1.9781 2.6100 0.0091 0.4225 FAM183B 22.3238 3.0493 1.1693 2.6078 0.0091 0.4244 HIST1H2BC 6114.9442 -1.3791 0.5291 -2.6064 0.0091 0.4251 NPTXR 282.1166 1.0018 0.3846 2.6046 0.0092 0.4265 SLC35E2B 1242.3764 -1.0334 0.3979 -2.5969 0.0094 0.4296 AC092798.2 135.8728 0.8670 0.3336 2.5992 0.0093 0.4296 STX11 186.5552 1.5024 0.5780 2.5994 0.0093 0.4296 AC005740.4 10.7509 1.7144 0.6591 2.6012 0.0093 0.4296 C3 88710.9420 1.7570 0.6760 2.5989 0.0094 0.4296 IGFL1 11.4057 3.5620 1.3711 2.5979 0.0094 0.4296 IGHV3-19 17.7648 4.7479 1.8281 2.5972 0.0094 0.4296 C2orf81 158.9915 -1.1616 0.4475 -2.5958 0.0094 0.4301 CYP24A1 109.0202 2.5522 0.9857 2.5892 0.0096 0.4374 SYNE4 269.0245 -1.6348 0.6329 -2.5831 0.0098 0.4405 KCNB1 144.4498 1.4365 0.5561 2.5833 0.0098 0.4405 TGM4 31.6787 2.1096 0.8164 2.5840 0.0098 0.4405 CNTNAP3B 282.2481 2.1605 0.8360 2.5843 0.0098 0.4405 EMX1 21.6816 2.3677 0.9160 2.5848 0.0097 0.4405 MEIOB 55.8157 2.0785 0.8059 2.5792 0.0099 0.4446 DACH1 1205.0097 -1.7321 0.6724 -2.5761 0.0100 0.4462 GPX7 360.0349 -1.0084 0.3914 -2.5762 0.0100 0.4462 UBE2R2 4077.6975 -0.6753 0.2624 -2.5733 0.0101 0.4462 SCCPDH 1921.8619 -0.5356 0.2080 -2.5749 0.0100 0.4462 SRSF3 5345.1831 -0.4997 0.1942 -2.5725 0.0101 0.4462 MED28 1817.7616 -0.3689 0.1434 -2.5722 0.0101 0.4462 RP11-982M15.6 13.6042 2.5914 1.0072 2.5728 0.0101 0.4462 OR10J3 13.8406 4.7643 1.8517 2.5729 0.0101 0.4462 ZNF99 2236.2651 -2.0695 0.8054 -2.5696 0.0102 0.4471 CTNNA2 327.6033 -1.7741 0.6906 -2.5689 0.0102 0.4471 SLC2A12 453.7992 -1.5276 0.5949 -2.5678 0.0102 0.4471 PTRHD1 189.6409 -0.8526 0.3322 -2.5665 0.0103 0.4471 GPR125 7238.1645 -0.6732 0.2623 -2.5668 0.0103 0.4471 B3GAT1 140.7416 2.1881 0.8520 2.5682 0.0102 0.4471 GHRHR 16.3073 3.6524 1.4215 2.5694 0.0102 0.4471 SLC30A6 4926.9282 -0.5251 0.2048 -2.5640 0.0103 0.4484 GPR114 66.5694 1.8239 0.7112 2.5646 0.0103 0.4484 UPF2 6310.9327 -0.8170 0.3189 -2.5621 0.0104 0.4488 MICALL2 490.8338 0.7938 0.3099 2.5618 0.0104 0.4488 C7orf71 40.6920 1.3159 0.5139 2.5609 0.0104 0.4488 LIPN 19.0444 2.7613 1.0780 2.5616 0.0104 0.4488 SLC7A4 60.7085 1.1383 0.4449 2.5589 0.0105 0.4505 C2orf83 19.9581 3.7052 1.4489 2.5572 0.0106 0.4515 CYP2C19 31.1109 4.0424 1.5811 2.5567 0.0106 0.4515 ASS1P7 9.5766 -1.9289 0.7554 -2.5534 0.0107 0.4523 NPIPB7 82.6237 -1.1186 0.4381 -2.5533 0.0107 0.4523 PIGA 885.5253 0.6139 0.2404 2.5535 0.0107 0.4523 ACTA1 19.4174 2.9600 1.1589 2.5542 0.0106 0.4523 AMY1C 20.0908 -6.8026 2.6655 -2.5521 0.0107 0.4530 RUNDC3A 54.1535 1.4074 0.5517 2.5509 0.0107 0.4537 APTX 2055.5927 -0.5593 0.2194 -2.5492 0.0108 0.4549 NR3C1 8783.0008 0.7259 0.2849 2.5480 0.0108 0.4556 APOBEC3H 28.9627 1.4231 0.5587 2.5472 0.0109 0.4558 PAX3 112.5858 -5.4821 2.1551 -2.5438 0.0110 0.4584 RP11-567G24.1 31.1397 2.3185 0.9114 2.5439 0.0110 0.4584 AMY1B 156.6383 -2.9321 1.1535 -2.5419 0.0110 0.4585 RBBP4 5843.4678 -0.7116 0.2801 -2.5403 0.0111 0.4585 GCFC2 1925.0662 -0.5448 0.2144 -2.5409 0.0111 0.4585 HRNR 4881.8451 1.1049 0.4349 2.5408 0.0111 0.4585 RPEP3 17.2774 1.1930 0.4693 2.5419 0.0110 0.4585 BFSP1 82.0617 1.3727 0.5405 2.5397 0.0111 0.4585 POU4F1 38.9370 3.4765 1.3700 2.5375 0.0112 0.4595 TEX13A 9.1763 4.5341 1.7865 2.5379 0.0112 0.4595 FIBIN 795.7411 -0.9595 0.3783 -2.5366 0.0112 0.4597 PTK7 3551.7963 -0.8471 0.3341 -2.5354 0.0112 0.4597 IGF2-AS 17.5168 4.3614 1.7199 2.5358 0.0112 0.4597 MMEL1 66.2028 2.3075 0.9104 2.5345 0.0113 0.4599 VPS52 1540.9364 -0.7190 0.2839 -2.5329 0.0113 0.4599 PDZK1P1 56.0286 2.9507 1.1645 2.5338 0.0113 0.4599 UBTFL6 12.1482 3.0965 1.2227 2.5325 0.0113 0.4599 PAMR1 262.5919 1.9115 0.7552 2.5311 0.0114 0.4609 TAS2R5 365.3123 -0.9519 0.3767 -2.5272 0.0115 0.4643 FBXO5 600.6888 -0.7794 0.3084 -2.5272 0.0115 0.4643 KIAA1161 378.6988 -1.0958 0.4338 -2.5260 0.0115 0.4650 UBD 32.1346 3.1557 1.2497 2.5252 0.0116 0.4651 POTED 30.7263 -5.1888 2.0559 -2.5238 0.0116 0.4661 KLHDC3 2975.7076 -0.7897 0.3134 -2.5199 0.0117 0.4674 UBA3 2830.4586 -0.6184 0.2453 -2.5204 0.0117 0.4674 SUPT7L 3024.4445 -0.5293 0.2099 -2.5211 0.0117 0.4674 DNAJC5B 34.0428 2.0691 0.8212 2.5195 0.0118 0.4674 L1CAM 1822.6480 2.2559 0.8946 2.5218 0.0117 0.4674 KIF5C 2409.8495 -1.4739 0.5856 -2.5169 0.0118 0.4682 PLA2G4C 133.9796 1.0646 0.4228 2.5180 0.0118 0.4682 ZBP1 189.9019 1.3789 0.5479 2.5166 0.0118 0.4682 FAM166A 20.4139 1.8331 0.7285 2.5161 0.0119 0.4682 TMEM40 26.2503 2.5743 1.0236 2.5150 0.0119 0.4682 SOX21 23.3207 4.3776 1.7405 2.5151 0.0119 0.4682 FRZB 1354.7565 -1.5659 0.6232 -2.5129 0.0120 0.4693 CTD-2373J19.1 30.8397 3.7075 1.4751 2.5133 0.0120 0.4693 OR52K2 41.3484 2.4253 0.9658 2.5113 0.0120 0.4706 SPAST 5289.6682 -0.5427 0.2162 -2.5103 0.0121 0.4710 SPN 197.0525 1.4647 0.5837 2.5096 0.0121 0.4711 PCDHGC5 115.5704 0.8715 0.3474 2.5084 0.0121 0.4718 ZBTB5 1509.3346 -0.6806 0.2716 -2.5057 0.0122 0.4726 ANO3 131.6270 1.5779 0.6296 2.5061 0.0122 0.4726 IGHV3-74 160.3857 1.9775 0.7890 2.5062 0.0122 0.4726 KRT6C 32.3609 2.1139 0.8438 2.5052 0.0122 0.4726 NACAP1 9.5577 2.8254 1.1282 2.5044 0.0123 0.4729 G6PC 27.3911 4.5998 1.8383 2.5023 0.0123 0.4749 MST1R 482.3308 1.0007 0.4001 2.5008 0.0124 0.4759 CBX5 10442.0402 -0.6059 0.2425 -2.4991 0.0124 0.4765 PKD1L2 380.5924 1.0810 0.4326 2.4991 0.0125 0.4765 PAM 10445.8559 -0.6732 0.2695 -2.4983 0.0125 0.4767 MRAP 59.4251 0.9741 0.3902 2.4962 0.0126 0.4778 TRPC5OS 12.7571 4.0301 1.6140 2.4969 0.0125 0.4778 UGT8 893.4184 -1.0951 0.4390 -2.4948 0.0126 0.4789 ATF4P4 9.1486 2.5315 1.0151 2.4938 0.0126 0.4794 ACTBP8 15.6621 5.0060 2.0092 2.4915 0.0127 0.4816 AL359878.1 32.8496 -1.8808 0.7553 -2.4900 0.0128 0.4821 DENND1C 449.4822 0.9361 0.3760 2.4899 0.0128 0.4821 ZNF268 1289.1350 -0.7521 0.3025 -2.4862 0.0129 0.4825 SUFU 1230.6788 -0.3879 0.1561 -2.4856 0.0129 0.4825 RAB30 2823.1633 0.9234 0.3711 2.4882 0.0128 0.4825 UGT2B7 3713.0575 1.1163 0.4493 2.4847 0.0130 0.4825 TRAJ22 19.4540 1.6030 0.6452 2.4846 0.0130 0.4825 CTD-2501B8.5 35.3411 1.8961 0.7627 2.4861 0.0129 0.4825 BPIFC 37.8185 2.6062 1.0475 2.4881 0.0128 0.4825 PNLIPRP2 24.0021 3.7432 1.5064 2.4849 0.0130 0.4825 RP1-257A7.4 36.5968 -0.7794 0.3139 -2.4826 0.0130 0.4844 CDH18 258.4613 -3.2442 1.3071 -2.4819 0.0131 0.4845 PDIA2 97.0697 -1.8700 0.7541 -2.4798 0.0131 0.4856 ZNF439 3411.0477 -0.8779 0.3540 -2.4802 0.0131 0.4856 AMER2 99.2576 3.9315 1.5858 2.4792 0.0132 0.4856 NDC1 3543.8147 -0.8944 0.3609 -2.4783 0.0132 0.4860 NEDD4L 2805.3697 -0.8931 0.3606 -2.4768 0.0133 0.4860 ANKLE2 4079.2913 -0.5800 0.2342 -2.4765 0.0133 0.4860 DEFB1 343.7874 3.1803 1.2837 2.4775 0.0132 0.4860 KIF21B 338.8232 1.1509 0.4653 2.4736 0.0134 0.4874 CELF5 71.8670 1.9600 0.7924 2.4736 0.0134 0.4874 TLE6 39.6956 1.9634 0.7935 2.4743 0.0134 0.4874 SFPQ 22823.4513 -0.4374 0.1769 -2.4723 0.0134 0.4875 F12 66.4777 1.2421 0.5023 2.4729 0.0134 0.4875 MS4A13 20.1730 -6.0629 2.4614 -2.4632 0.0138 0.4942 HMGN2P41 29.8048 -3.8971 1.5869 -2.4557 0.0141 0.4942 IGKV1OR2-108 207.6645 -2.3432 0.9518 -2.4620 0.0138 0.4942 KLHL23 2220.4095 -0.9290 0.3779 -2.4582 0.0140 0.4942 PITRM1 6821.5556 -0.8660 0.3529 -2.4536 0.0141 0.4942 PARD6G 373.4169 -0.8295 0.3372 -2.4602 0.0139 0.4942 TRIM27 1744.8133 -0.7267 0.2958 -2.4563 0.0140 0.4942 BRPF3 2598.5821 -0.7170 0.2909 -2.4652 0.0137 0.4942 HDAC2 5123.8708 -0.7072 0.2881 -2.4551 0.0141 0.4942 WDR37 1447.8183 -0.6528 0.2655 -2.4587 0.0139 0.4942 ZSCAN16 500.7755 -0.6210 0.2528 -2.4563 0.0140 0.4942 LUC7L 2392.8052 -0.5675 0.2313 -2.4536 0.0141 0.4942 TIMM23 858.5167 -0.4821 0.1962 -2.4576 0.0140 0.4942 DR1 1886.0786 -0.4615 0.1880 -2.4550 0.0141 0.4942 SYN1 201.6003 0.9797 0.3980 2.4613 0.0138 0.4942 RFX2 264.5989 1.0646 0.4320 2.4645 0.0137 0.4942 CYP46A1 78.4302 1.2370 0.5028 2.4600 0.0139 0.4942 RP11-611O2.6 42.9550 1.3134 0.5327 2.4657 0.0137 0.4942 UPP1 210.7650 1.3824 0.5634 2.4539 0.0141 0.4942 KB-1517D11.2 10.0614 2.0808 0.8440 2.4655 0.0137 0.4942 SLC12A5 90.9040 2.0848 0.8475 2.4599 0.0139 0.4942 YBX2P1 12.1882 2.3174 0.9427 2.4581 0.0140 0.4942 HNRNPCP5 10.4059 4.2633 1.7340 2.4587 0.0139 0.4942 ZNF93 4524.4700 -0.7660 0.3124 -2.4518 0.0142 0.4951 NKG7 86.4713 1.7860 0.7283 2.4523 0.0142 0.4951 PRSS37 247.9143 -1.0890 0.4445 -2.4498 0.0143 0.4954 C22orf34 239.5883 1.6248 0.6633 2.4497 0.0143 0.4954 NKX3-1 115.5696 1.7064 0.6970 2.4483 0.0144 0.4954 GPR115 38.6091 1.9511 0.7971 2.4478 0.0144 0.4954 RP11-428P16.2 188.6492 1.9890 0.8123 2.4487 0.0143 0.4954 HTR2A 81.5484 2.3291 0.9507 2.4500 0.0143 0.4954 SAG 29.2284 2.4317 0.9935 2.4475 0.0144 0.4954 TECRL 89.1999 5.3764 2.1979 2.4461 0.0144 0.4964 GPC3 727.4046 -2.1394 0.8775 -2.4380 0.0148 0.4979 TEX10 2581.9543 -0.8141 0.3338 -2.4387 0.0147 0.4979 HAUS6 2021.5157 -0.7768 0.3181 -2.4421 0.0146 0.4979 RAN 3162.9273 -0.5445 0.2229 -2.4430 0.0146 0.4979 EPSTI1 1867.6788 1.0990 0.4502 2.4408 0.0147 0.4979 JAKMIP3 194.6456 1.3480 0.5520 2.4420 0.0146 0.4979 SLFN14 44.0062 1.5475 0.6346 2.4385 0.0147 0.4979 CXorf58 30.5358 1.6898 0.6932 2.4375 0.0148 0.4979 LIPM 17.3544 2.0098 0.8237 2.4399 0.0147 0.4979 ULBP2 44.6679 2.5237 1.0332 2.4427 0.0146 0.4979 MIR598 11.6470 2.6113 1.0692 2.4422 0.0146 0.4979 AQP10 29.4575 3.4224 1.4039 2.4377 0.0148 0.4979 FAM150A 17.7071 3.4583 1.4169 2.4408 0.0147 0.4979 MAGEB6 16.3678 4.6192 1.8970 2.4350 0.0149 0.5006 C10orf111 85.3770 -0.9648 0.3966 -2.4328 0.0150 0.5016 PPHLN1 3085.0014 -0.5656 0.2325 -2.4326 0.0150 0.5016 BDKRB2 47.2606 1.6880 0.6937 2.4335 0.0150 0.5016 ZNF260 4835.9963 -0.7851 0.3229 -2.4311 0.0151 0.5029 ARSH 19.2045 2.9857 1.2288 2.4298 0.0151 0.5032 SYNDIG1L 11.5540 3.1295 1.2880 2.4297 0.0151 0.5032 C15orf52 473.0704 1.2551 0.5167 2.4291 0.0151 0.5033 HSPA14 1978.7462 -0.6890 0.2839 -2.4265 0.0152 0.5046 ZFP82 671.5878 -0.5489 0.2261 -2.4272 0.0152 0.5046 RP4-605O3.4 63.0794 0.6543 0.2697 2.4265 0.0152 0.5046 SNORD114-6 26.6093 1.9718 0.8129 2.4256 0.0153 0.5050 GTF2H5 1097.7826 -0.7200 0.2969 -2.4246 0.0153 0.5056 PFKM 10851.8857 -1.2793 0.5280 -2.4232 0.0154 0.5068 C6orf123 25.4347 1.6131 0.6662 2.4213 0.0155 0.5081 THEG 19.8144 4.8166 1.9894 2.4211 0.0155 0.5081 ZBTB22 820.6350 -0.7783 0.3216 -2.4198 0.0155 0.5084 RPH3AL 110.9139 1.3281 0.5488 2.4201 0.0155 0.5084 ZNF461 1288.7861 -0.7447 0.3081 -2.4168 0.0157 0.5087 FBXO39 63.1133 1.2875 0.5323 2.4186 0.0156 0.5087 H1FNT 19.7093 2.5989 1.0751 2.4173 0.0156 0.5087 MEP1A 30.2428 4.1580 1.7204 2.4170 0.0157 0.5087 NOX3 20.5776 4.3888 1.8150 2.4181 0.0156 0.5087 FAT3 895.0729 1.6518 0.6837 2.4160 0.0157 0.5090 MTAP 2638.3521 -0.7342 0.3042 -2.4136 0.0158 0.5110 RP11-204N11.1 26.4000 2.8309 1.1729 2.4135 0.0158 0.5110 ANKRD20A18P 228.1851 -1.3421 0.5573 -2.4081 0.0160 0.5124 CENPU 801.3937 -0.9489 0.3942 -2.4070 0.0161 0.5124 ZNF850 3022.6052 -0.7890 0.3276 -2.4086 0.0160 0.5124 MTF2 3953.5493 -0.5514 0.2290 -2.4077 0.0161 0.5124 SOD2 11174.8043 0.6215 0.2582 2.4071 0.0161 0.5124 SNORA60 193.1599 0.7998 0.3319 2.4095 0.0160 0.5124 TBC1D3G 214.0369 1.2515 0.5194 2.4094 0.0160 0.5124 GJC3 85.9171 1.5329 0.6358 2.4111 0.0159 0.5124 GPAT2 38.6876 1.7644 0.7322 2.4096 0.0160 0.5124 OR6M1 12.1116 3.4096 1.4158 2.4083 0.0160 0.5124 LYNX1 278.1608 0.7367 0.3062 2.4062 0.0161 0.5127 AC069213.1 1026.9501 -1.5714 0.6537 -2.4037 0.0162 0.5154 RP11-173D9.5 14.6839 0.9950 0.4142 2.4024 0.0163 0.5165 ZNF784 104.6723 0.7848 0.3271 2.3995 0.0164 0.5191 NR1I3 64.3008 0.8894 0.3706 2.4000 0.0164 0.5191 LRRC43 146.3986 0.9911 0.4133 2.3976 0.0165 0.5210 IGHV1-58 189.7349 7.1645 2.9890 2.3970 0.0165 0.5212 CTC-451A6.4 32.7559 -1.7428 0.7276 -2.3952 0.0166 0.5213 NLRP6 54.7750 1.6534 0.6902 2.3955 0.0166 0.5213 AGXT2 10.4135 3.4748 1.4503 2.3959 0.0166 0.5213 PLXNA4 1041.4856 -0.9506 0.3972 -2.3932 0.0167 0.5234 RP11-848G14.5 986.4482 0.8286 0.3465 2.3914 0.0168 0.5252 RPS4XP16 120.2243 -1.1075 0.4634 -2.3898 0.0169 0.5267 TIA1 10717.4295 -0.5656 0.2368 -2.3888 0.0169 0.5267 SYT5 39.3808 3.0381 1.2718 2.3888 0.0169 0.5267 NPIPA8 44.2930 -2.7207 1.1399 -2.3868 0.0170 0.5275 PLLP 173.8174 -1.6204 0.6791 -2.3861 0.0170 0.5275 RPS6KA3 10244.0959 0.8564 0.3587 2.3876 0.0170 0.5275 RARRES3 799.8779 1.1206 0.4696 2.3863 0.0170 0.5275 RP11-763F8.1 186.6438 -1.7255 0.7235 -2.3850 0.0171 0.5282 ARL4A 542.6639 -0.9639 0.4051 -2.3796 0.0173 0.5308 RPP38 241.8176 -0.5412 0.2274 -2.3801 0.0173 0.5308 WDR25 411.8372 0.5110 0.2147 2.3802 0.0173 0.5308 GZMH 28.6987 1.5330 0.6442 2.3795 0.0173 0.5308 BRDT 27.0427 2.4283 1.0205 2.3796 0.0173 0.5308 IL19 15.7401 2.7737 1.1650 2.3808 0.0173 0.5308 FAM47C 36.9972 3.9386 1.6538 2.3815 0.0172 0.5308 HIST1H3A 287.6344 -1.1666 0.4905 -2.3784 0.0174 0.5310 ZNF320 3294.5301 -0.7137 0.3001 -2.3778 0.0174 0.5310 C4orf6 16.8982 1.4529 0.6112 2.3773 0.0174 0.5310 ST8SIA6 106.7006 2.2340 0.9398 2.3773 0.0174 0.5310 XPO5 4459.4090 -0.7685 0.3236 -2.3750 0.0175 0.5314 DCAF10 1877.4784 -0.5903 0.2486 -2.3749 0.0176 0.5314 INSC 42.2488 3.2782 1.3795 2.3764 0.0175 0.5314 IFNA14 9.4255 5.1626 2.1738 2.3749 0.0176 0.5314 PCP4 175.5681 -2.4841 1.0473 -2.3719 0.0177 0.5326 DAPL1 699.3100 -2.0394 0.8597 -2.3722 0.0177 0.5326 FOXRED2 1270.5245 -0.8418 0.3547 -2.3734 0.0176 0.5326 SSX3 15.6449 5.6892 2.3983 2.3722 0.0177 0.5326 MSH2 8638.0733 -0.8261 0.3485 -2.3708 0.0177 0.5327 CPEB4 4454.1618 0.7014 0.2958 2.3710 0.0177 0.5327 FAM20A 3425.7011 1.0221 0.4312 2.3702 0.0178 0.5329 EHMT2 3160.0895 -0.9758 0.4120 -2.3686 0.0179 0.5344 ZNF644 18948.6627 -0.5984 0.2528 -2.3672 0.0179 0.5356 CHML 4523.5114 -0.5968 0.2525 -2.3633 0.0181 0.5377 PCMT1 1453.1537 -0.4238 0.1793 -2.3636 0.0181 0.5377 UTP15 862.3529 0.5867 0.2482 2.3640 0.0181 0.5377 OR1B1 32.2329 2.1661 0.9164 2.3637 0.0181 0.5377 KRT8P7 13.4812 2.5271 1.0688 2.3645 0.0181 0.5377 SPDYE8P 57.0932 -1.8634 0.7895 -2.3602 0.0183 0.5378 FAM208B 9452.5611 -0.7176 0.3040 -2.3605 0.0182 0.5378 LY75 691.5927 0.7629 0.3230 2.3624 0.0182 0.5378 SCN4B 625.7900 1.0838 0.4594 2.3590 0.0183 0.5378 NR2E3 116.0144 1.6717 0.7084 2.3600 0.0183 0.5378 U1 35.6527 2.1442 0.9087 2.3596 0.0183 0.5378 RP11-64K7.1 28.8464 2.7384 1.1608 2.3591 0.0183 0.5378 AC096574.4 11.5632 3.5261 1.4935 2.3610 0.0182 0.5378 AADACL2 146.4032 2.0634 0.8750 2.3583 0.0184 0.5381 IFI27 2740.8502 1.2594 0.5348 2.3549 0.0185 0.5415 HTR1D 22.9970 2.7218 1.1558 2.3549 0.0185 0.5415 RP11-288C17.1 38.4143 -2.8791 1.2237 -2.3528 0.0186 0.5431 CCL20 252.4971 -2.3191 0.9856 -2.3530 0.0186 0.5431 RP11-284B18.3 15.9686 1.6654 0.7080 2.3521 0.0187 0.5434 HCRTR2 17.0398 2.6569 1.1299 2.3516 0.0187 0.5435 LRRC42 1030.5313 -0.8489 0.3612 -2.3501 0.0188 0.5442 IRF5 263.9208 0.6964 0.2963 2.3500 0.0188 0.5442 ZNF521 1959.6253 -1.3199 0.5625 -2.3467 0.0189 0.5484 OSCAR 73.4562 1.2778 0.5451 2.3440 0.0191 0.5516 C20orf194 3721.5478 0.5386 0.2299 2.3431 0.0191 0.5522 MS4A18 15.8540 -5.6510 2.4130 -2.3418 0.0192 0.5530 PCDHA11 277.8963 1.1985 0.5119 2.3415 0.0192 0.5530 SNCB 14.1007 2.9929 1.2789 2.3402 0.0193 0.5543 KCNH6 35.4954 3.4107 1.4579 2.3395 0.0193 0.5546 BMP7 1683.4498 -2.3592 1.0104 -2.3350 0.0195 0.5550 POU5F1 701.4329 -1.6204 0.6947 -2.3324 0.0197 0.5550 A2ML1 338.2306 -1.5787 0.6786 -2.3263 0.0200 0.5550 CAPN6 164.6081 -1.4971 0.6431 -2.3281 0.0199 0.5550 LSM2 411.4370 -0.9208 0.3946 -2.3336 0.0196 0.5550 PFDN6 197.0718 -0.8336 0.3567 -2.3372 0.0194 0.5550 TTC21B 8160.3960 -0.7096 0.3036 -2.3376 0.0194 0.5550 TEAD3 972.6943 -0.6804 0.2918 -2.3314 0.0197 0.5550 C6orf89 3084.2583 -0.5535 0.2372 -2.3334 0.0196 0.5550 C15orf62 124.8899 0.7130 0.3058 2.3312 0.0197 0.5550 STAP2 349.9982 0.7940 0.3413 2.3262 0.0200 0.5550 SCAMP5 220.1467 0.8046 0.3454 2.3295 0.0198 0.5550 ITGAL 402.9700 1.1482 0.4918 2.3349 0.0196 0.5550 ANKRD1 88.8098 1.3390 0.5748 2.3294 0.0198 0.5550 CPM 1593.5802 1.3974 0.6006 2.3266 0.0200 0.5550 TRGC2 94.0635 1.4316 0.6154 2.3261 0.0200 0.5550 FBP1 264.0752 1.4689 0.6300 2.3318 0.0197 0.5550 CLCNKA 196.9587 1.6177 0.6949 2.3279 0.0199 0.5550 GTF2IRD2P1 59.4298 1.6673 0.7157 2.3298 0.0198 0.5550 CHRNA3 56.3246 1.7102 0.7317 2.3372 0.0194 0.5550 OR1L8 42.8813 2.0614 0.8834 2.3336 0.0196 0.5550 IL21R 90.2743 2.0618 0.8856 2.3280 0.0199 0.5550 CNTN6 88.9873 2.0972 0.9017 2.3258 0.0200 0.5550 C10orf99 25.7674 2.3070 0.9914 2.3271 0.0200 0.5550 ADAM7 41.0794 2.8988 1.2436 2.3309 0.0198 0.5550 GLRA3 127.1649 3.0220 1.2948 2.3339 0.0196 0.5550 MORC1 43.3287 3.7041 1.5911 2.3280 0.0199 0.5550 CRYGC 52.5258 -2.7650 1.1899 -2.3237 0.0201 0.5559 C1QL1 31.7886 1.2740 0.5481 2.3243 0.0201 0.5559 SLC22A2 62.4830 3.0605 1.3168 2.3242 0.0201 0.5559 TDRD5 635.9034 -1.5926 0.6855 -2.3230 0.0202 0.5562 PLCB1 3232.3593 1.0984 0.4733 2.3208 0.0203 0.5581 RPSAP47 26.8546 1.5167 0.6534 2.3212 0.0203 0.5581 TNFSF14 118.7002 2.2560 0.9724 2.3202 0.0203 0.5583 MIR557 12.3588 -4.4329 1.9114 -2.3192 0.0204 0.5590 OR8D4 17.3181 2.6874 1.1590 2.3187 0.0204 0.5590 UGT2B17 714.2921 -3.9787 1.7188 -2.3148 0.0206 0.5601 NOLC1 3321.9476 -0.7479 0.3230 -2.3154 0.0206 0.5601 PITHD1 1315.5279 -0.6644 0.2869 -2.3163 0.0205 0.5601 H3F3A 3814.3001 -0.5381 0.2326 -2.3139 0.0207 0.5601 GTF3C2 2594.9649 -0.4982 0.2153 -2.3137 0.0207 0.5601 FAM114A2 1586.6698 0.3726 0.1608 2.3174 0.0205 0.5601 WNT3A 42.8501 1.9939 0.8616 2.3141 0.0207 0.5601 GPR141 104.2621 2.3152 1.0002 2.3147 0.0206 0.5601 KIR2DP1 18.8052 5.4136 2.3366 2.3169 0.0205 0.5601 LINC00176 68.8084 -1.6165 0.6997 -2.3102 0.0209 0.5620 JAG1 5869.4973 0.5847 0.2531 2.3100 0.0209 0.5620 AMICA1 250.6226 1.1860 0.5133 2.3106 0.0209 0.5620 CHCHD4P4 13.7721 1.7548 0.7596 2.3101 0.0209 0.5620 NAA11 81.0742 5.1920 2.2465 2.3112 0.0208 0.5620 OTOL1 9.7649 5.0755 2.1983 2.3088 0.0210 0.5630 ZNF568 1188.8008 -0.7414 0.3213 -2.3077 0.0210 0.5640 SLC22A15 446.8105 0.9974 0.4324 2.3065 0.0211 0.5643 MROH2B 98.3059 2.5868 1.1214 2.3067 0.0211 0.5643 PDZD4 145.2011 1.5298 0.6634 2.3059 0.0211 0.5645 SLC30A2 66.9870 1.7546 0.7612 2.3050 0.0212 0.5651 OR8G3P 22.0377 -6.9279 3.0074 -2.3036 0.0212 0.5658 PLA2G2F 15.2912 3.2916 1.4288 2.3038 0.0212 0.5658 CPLX2 77.5288 1.7141 0.7445 2.3024 0.0213 0.5663 NPM2 32.1258 1.7294 0.7511 2.3024 0.0213 0.5663 IGSF9B 644.8726 1.5721 0.6830 2.3018 0.0213 0.5664 C6orf57 158.5095 -0.9093 0.3952 -2.3006 0.0214 0.5670 SUV39H2 1373.3474 -0.7099 0.3089 -2.2986 0.0215 0.5670 MED4 1876.0728 -0.6798 0.2956 -2.2994 0.0215 0.5670 CYP3A5 1774.1824 1.1277 0.4904 2.2995 0.0215 0.5670 CYP51A1P2 26.8709 1.1788 0.5129 2.2981 0.0216 0.5670 C12orf77 15.7079 2.3133 1.0065 2.2984 0.0215 0.5670 LINC00692 15.8455 3.2525 1.4142 2.3000 0.0214 0.5670 TUBB8P1 120.2995 -0.8377 0.3650 -2.2950 0.0217 0.5710 MID1IP1 456.1212 0.5943 0.2592 2.2930 0.0218 0.5711 CCDC96 35.1556 1.4015 0.6111 2.2934 0.0218 0.5711 OR1L3 35.6519 2.6256 1.1444 2.2943 0.0218 0.5711 IGHV3OR15-7 27.2411 4.0689 1.7738 2.2939 0.0218 0.5711 ACTG1P3 36.8007 0.7160 0.3124 2.2920 0.0219 0.5718 ALDH7A1P1 40.3848 1.7951 0.7833 2.2916 0.0219 0.5718 BHLHE22 30.7440 2.1016 0.9178 2.2897 0.0220 0.5740 IL32 469.5835 1.1337 0.4955 2.2881 0.0221 0.5758 KRT13 44.6428 -2.9306 1.2827 -2.2847 0.0223 0.5782 STAMBP 1796.2304 -0.4443 0.1944 -2.2858 0.0223 0.5782 RAB10 7785.5470 -0.4303 0.1884 -2.2838 0.0224 0.5782 WWOX 1566.1799 0.5273 0.2309 2.2837 0.0224 0.5782 PRDM7 82.6055 1.8553 0.8120 2.2848 0.0223 0.5782 ZNF859P 58.3107 1.9602 0.8582 2.2841 0.0224 0.5782 ARID3C 41.6362 -2.6394 1.1574 -2.2805 0.0226 0.5824 C2orf68 657.9265 -0.6028 0.2644 -2.2798 0.0226 0.5825 CPA6 40.0611 2.4442 1.0722 2.2795 0.0226 0.5825 MEX3C 2619.8614 -0.5667 0.2487 -2.2789 0.0227 0.5825 RP11-1055B8.7 375.6736 1.0786 0.4735 2.2781 0.0227 0.5825 CDH15 130.8854 2.0968 0.9203 2.2783 0.0227 0.5825 IL15 717.6409 0.9571 0.4204 2.2765 0.0228 0.5835 MCF2L2 231.7992 1.3635 0.5990 2.2765 0.0228 0.5835 OR7G3 9.7319 3.9502 1.7362 2.2752 0.0229 0.5848 REP15 22.4257 -1.7846 0.7847 -2.2744 0.0229 0.5851 AMOT 4017.6790 -0.9023 0.3969 -2.2731 0.0230 0.5851 AURKC 84.9712 0.9996 0.4398 2.2727 0.0230 0.5851 DNAJC15 1031.2032 1.5852 0.6978 2.2719 0.0231 0.5851 C19orf77 39.1610 1.6361 0.7195 2.2740 0.0230 0.5851 NLRP12 79.7217 1.6667 0.7335 2.2722 0.0231 0.5851 SLC2A7 13.1032 2.9248 1.2866 2.2733 0.0230 0.5851 SLC10A6 27.7003 1.6853 0.7420 2.2714 0.0231 0.5851 POTEH 2948.2089 -4.1172 1.8144 -2.2692 0.0233 0.5863 RPL7L1 1529.5279 -0.6104 0.2689 -2.2700 0.0232 0.5863 KRT18P61 9.9708 1.2009 0.5293 2.2688 0.0233 0.5863 ABCC6P1 52.0060 2.7613 1.2169 2.2691 0.0233 0.5863 SIAH3 100.9750 -1.9519 0.8615 -2.2659 0.0235 0.5872 ZFAND3 2401.0983 -0.6993 0.3089 -2.2640 0.0236 0.5872 LDB1 5277.9009 -0.6357 0.2808 -2.2641 0.0236 0.5872 MAPK14 2442.6943 -0.5388 0.2376 -2.2677 0.0233 0.5872 SERPIND1 322.2108 0.5373 0.2372 2.2652 0.0235 0.5872 SETD9 169.3722 0.8098 0.3573 2.2666 0.0234 0.5872 SNORD59A 21.2391 1.1044 0.4879 2.2637 0.0236 0.5872 C12orf80 14.1453 1.6036 0.7073 2.2671 0.0234 0.5872 KIR3DX1 26.8451 2.5543 1.1284 2.2637 0.0236 0.5872 OTOR 9.8409 3.6397 1.6077 2.2639 0.0236 0.5872 NUDT16L1 149.6054 -0.7722 0.3413 -2.2628 0.0236 0.5879 RP11-359M6.2 22.0066 -1.0982 0.4856 -2.2616 0.0237 0.5883 RP11-589F5.3 309.6243 1.0669 0.4717 2.2617 0.0237 0.5883 ATAT1 1111.1185 -0.6767 0.2994 -2.2603 0.0238 0.5897 ZCCHC11 9940.8013 -0.6608 0.2924 -2.2595 0.0239 0.5902 ATF7IP 15754.7406 -0.6064 0.2684 -2.2589 0.0239 0.5904 RORB 127.1103 1.5385 0.6814 2.2579 0.0239 0.5912 SRRM4 37.2020 3.2091 1.4218 2.2571 0.0240 0.5919 LIN7B 21.7165 1.4924 0.6616 2.2559 0.0241 0.5929 AC092295.7 238.1623 -0.7768 0.3445 -2.2548 0.0241 0.5940 PIGU 1079.7280 -0.6665 0.2958 -2.2532 0.0242 0.5943 SLAMF7 219.5186 1.3867 0.6154 2.2534 0.0242 0.5943 MGAT5B 56.0458 2.1225 0.9421 2.2528 0.0243 0.5943 P2RX5 56.8440 2.5949 1.1515 2.2535 0.0242 0.5943 OR8G1 26.3002 -4.7426 2.1252 -2.2316 0.0256 0.5946 LRRC55 548.4259 -2.5122 1.1238 -2.2355 0.0254 0.5946 IPMKP1 41.0014 -2.1074 0.9378 -2.2471 0.0246 0.5946 GLUD1P6 14.8122 -1.5092 0.6709 -2.2494 0.0245 0.5946 CABLES1 928.6707 -1.0807 0.4824 -2.2402 0.0251 0.5946 ZNF140 1292.3040 -0.8788 0.3922 -2.2408 0.0250 0.5946 CD200 1975.3822 -0.8289 0.3716 -2.2307 0.0257 0.5946 TUBG1 940.7268 -0.7265 0.3258 -2.2299 0.0258 0.5946 ILF3 12543.8052 -0.7172 0.3210 -2.2340 0.0255 0.5946 ZNF567 691.9264 -0.6951 0.3107 -2.2371 0.0253 0.5946 ZNF790 1640.7611 -0.6797 0.3031 -2.2426 0.0249 0.5946 MRPL42 2891.7286 -0.5818 0.2610 -2.2294 0.0258 0.5946 MTHFD2 1598.8798 -0.5716 0.2563 -2.2305 0.0257 0.5946 SEP15 4443.3132 -0.5549 0.2474 -2.2430 0.0249 0.5946 CALM2 8154.6181 -0.5270 0.2353 -2.2396 0.0251 0.5946 IGFBP7 6760.6958 -0.4919 0.2201 -2.2348 0.0254 0.5946 KCTD20 1826.3361 -0.4841 0.2172 -2.2295 0.0258 0.5946 TAF1B 1725.2976 -0.4313 0.1930 -2.2344 0.0255 0.5946 ZNF236 2916.0951 -0.3954 0.1770 -2.2335 0.0255 0.5946 XIAP 12480.9232 0.6355 0.2834 2.2420 0.0250 0.5946 MFSD12 871.6748 0.6658 0.2967 2.2443 0.0248 0.5946 FAM115C 263.3143 0.7202 0.3217 2.2385 0.0252 0.5946 SNORA13 142.5953 0.8918 0.3993 2.2335 0.0255 0.5946 CD97 1199.5785 0.9822 0.4404 2.2305 0.0257 0.5946 ITGB2 2191.4445 1.0323 0.4610 2.2391 0.0252 0.5946 GPD1 107.4819 1.0509 0.4699 2.2364 0.0253 0.5946 IRF1 1892.5747 1.1278 0.5044 2.2357 0.0254 0.5946 C10orf128 142.7917 1.1644 0.5189 2.2438 0.0248 0.5946 ZMYND15 207.7682 1.1719 0.5234 2.2392 0.0251 0.5946 SAMD8 2408.0497 1.1813 0.5275 2.2396 0.0251 0.5946 ITGAD 84.9144 1.2048 0.5379 2.2399 0.0251 0.5946 CAPN14 82.0678 1.2307 0.5482 2.2448 0.0248 0.5946 IL11 26.4911 1.2919 0.5743 2.2497 0.0245 0.5946 LILRA1 78.2996 1.3529 0.6018 2.2481 0.0246 0.5946 IL2RG 309.0875 1.3587 0.6064 2.2405 0.0251 0.5946 CD3E 271.8961 1.3876 0.6208 2.2352 0.0254 0.5946 RBMXL3 67.8791 1.3892 0.6226 2.2313 0.0257 0.5946 PTPRH 129.3748 1.3952 0.6237 2.2370 0.0253 0.5946 TCL6 22.7635 1.4124 0.6327 2.2323 0.0256 0.5946 DIRAS1 43.6326 1.5888 0.7101 2.2375 0.0253 0.5946 SPTSSB 101.7932 1.7115 0.7659 2.2346 0.0254 0.5946 IGHG3 1194.2634 1.7275 0.7745 2.2306 0.0257 0.5946 POU1F1 35.6573 1.7295 0.7684 2.2507 0.0244 0.5946 C2CD4B 41.7761 1.7804 0.7911 2.2504 0.0244 0.5946 SLC6A3 73.6622 2.3021 1.0264 2.2430 0.0249 0.5946 HLA-DQA2 208.7406 2.4657 1.1003 2.2409 0.0250 0.5946 PCDH20 97.6609 2.5014 1.1114 2.2507 0.0244 0.5946 TGM3 40.6034 2.6460 1.1782 2.2459 0.0247 0.5946 RP11-600F24.1 8.8715 2.6997 1.2109 2.2296 0.0258 0.5946 DUSP26 25.0925 2.7776 1.2430 2.2346 0.0254 0.5946 KLK4 18.9750 2.8344 1.2659 2.2391 0.0252 0.5946 RAG2 17.9882 2.9473 1.3173 2.2375 0.0253 0.5946 PROKR2 40.8860 3.0969 1.3792 2.2455 0.0247 0.5946 OR7E24 15.0002 4.3369 1.9278 2.2497 0.0245 0.5946 C6orf211 757.7233 -0.8224 0.3690 -2.2286 0.0258 0.5950 RP11-423F24.3 31.7996 1.5407 0.6920 2.2264 0.0260 0.5972 MIR921 9.4330 2.2136 0.9942 2.2264 0.0260 0.5972 ST20 354.6381 -1.0366 0.4660 -2.2245 0.0261 0.5993 ZNF589 2097.7063 -0.9312 0.4194 -2.2205 0.0264 0.5993 ZBTB9 289.1495 -0.6567 0.2957 -2.2207 0.0264 0.5993 PRPF38A 2351.4177 -0.6007 0.2704 -2.2216 0.0263 0.5993 MBD5 7505.4147 -0.4679 0.2106 -2.2215 0.0263 0.5993 SLC8A1 1334.7809 0.8591 0.3868 2.2209 0.0264 0.5993 SPTBN5 417.6704 0.9515 0.4284 2.2212 0.0263 0.5993 PDLIM4 526.5171 1.1827 0.5325 2.2210 0.0264 0.5993 HIGD1AP14 17.6485 1.2126 0.5456 2.2223 0.0263 0.5993 GAGE10 79.9044 1.5958 0.7177 2.2237 0.0262 0.5993 TMEM145 53.1575 2.1061 0.9474 2.2231 0.0262 0.5993 TCF7L1 1688.1388 -1.1067 0.4988 -2.2189 0.0265 0.6009 RAB15 445.1582 -0.8716 0.3929 -2.2184 0.0265 0.6009 ZNF346 586.7755 0.3949 0.1781 2.2179 0.0266 0.6009 ADCY10 177.8434 1.3948 0.6289 2.2177 0.0266 0.6009 SUPT20HL2 34.7316 2.5831 1.1651 2.2170 0.0266 0.6014 GLDN 327.9611 1.4931 0.6738 2.2158 0.0267 0.6027 ZNF607 1051.6052 -0.7475 0.3375 -2.2147 0.0268 0.6034 DUSP4 408.1437 1.8877 0.8524 2.2145 0.0268 0.6034 TUBB 16118.0599 -0.9665 0.4368 -2.2126 0.0269 0.6050 NET1 6366.4000 -0.7717 0.3493 -2.2096 0.0271 0.6050 ACTRT3 216.4455 -0.6391 0.2893 -2.2090 0.0272 0.6050 CENPO 363.0916 -0.5269 0.2385 -2.2089 0.0272 0.6050 ZSCAN30 973.8121 -0.4978 0.2250 -2.2121 0.0270 0.6050 RIBC1 173.5653 0.7688 0.3481 2.2085 0.0272 0.6050 L3MBTL2 518.9092 0.7784 0.3523 2.2097 0.0271 0.6050 GEM 740.7750 1.1927 0.5397 2.2098 0.0271 0.6050 TMEM190 22.9295 1.4278 0.6457 2.2113 0.0270 0.6050 RP11-1415C14.3 211.7810 1.4424 0.6523 2.2110 0.0270 0.6050 MUC13 59.4784 2.3688 1.0723 2.2090 0.0272 0.6050 CLLU1OS 9.7468 3.2618 1.4767 2.2089 0.0272 0.6050 FZD10 295.4441 -1.6522 0.7485 -2.2075 0.0273 0.6053 RP11-1094M14.8 33.0759 1.0916 0.4946 2.2068 0.0273 0.6053 RP5-837I24.1 9.7691 2.8407 1.2871 2.2070 0.0273 0.6053 REG1A 38.6476 3.0835 1.3973 2.2067 0.0273 0.6053 FAM26F 45.2392 1.0534 0.4776 2.2054 0.0274 0.6061 VMO1 40.9668 1.2599 0.5715 2.2046 0.0275 0.6061 SPEF1 55.0106 1.4333 0.6500 2.2052 0.0274 0.6061 DNAH2 2170.0362 1.5130 0.6862 2.2049 0.0275 0.6061 DSCR4 41.2991 -5.7425 2.6070 -2.2027 0.0276 0.6083 ASB5 54.6419 3.0653 1.3928 2.2008 0.0278 0.6107 ZNF257 1813.2466 -1.0856 0.4940 -2.1976 0.0280 0.6117 TXNL4A 1072.1103 -0.7918 0.3604 -2.1970 0.0280 0.6117 ZNF322 1886.4663 -0.7711 0.3509 -2.1976 0.0280 0.6117 UTP14C 2655.2669 -0.6097 0.2775 -2.1972 0.0280 0.6117 SLC26A4 112.6643 1.6396 0.7464 2.1969 0.0280 0.6117 GOLGA8Q 135.7508 1.9325 0.8798 2.1965 0.0281 0.6117 RP5-875O13.6 19.6438 2.0365 0.9259 2.1995 0.0278 0.6117 BMP5 35.0126 2.5081 1.1414 2.1975 0.0280 0.6117 C11orf44 23.6675 2.6378 1.1996 2.1990 0.0279 0.6117 COMMD3 179.8058 -0.6919 0.3151 -2.1961 0.0281 0.6118 RP11-146N23.1 33.3415 -1.0055 0.4582 -2.1946 0.0282 0.6128 GMCL1 2392.5817 -0.4822 0.2198 -2.1936 0.0283 0.6128 USP50 20.7846 1.4349 0.6544 2.1926 0.0283 0.6128 ANKRD19P 9.7688 2.9415 1.3409 2.1936 0.0283 0.6128 C10orf126 21.4260 3.6372 1.6588 2.1927 0.0283 0.6128 WFDC11 9.0367 4.9269 2.2451 2.1945 0.0282 0.6128 RP11-443J23.1 10.2803 5.4213 2.4717 2.1933 0.0283 0.6128 SLC16A1 5193.6875 -1.0076 0.4596 -2.1921 0.0284 0.6129 LRP4 4569.4571 -1.7509 0.7993 -2.1905 0.0285 0.6135 SIGMAR1 1152.0123 -0.8702 0.3979 -2.1871 0.0287 0.6135 SGPP2 1121.2736 -0.8539 0.3908 -2.1851 0.0289 0.6135 KIAA0355 2757.0199 -0.5078 0.2325 -2.1846 0.0289 0.6135 NACC2 699.1335 0.6407 0.2931 2.1862 0.0288 0.6135 PHF7 131.9415 0.6648 0.3037 2.1890 0.0286 0.6135 MTMR8 389.1792 0.8687 0.3975 2.1855 0.0289 0.6135 SNORA5C 70.6003 1.0765 0.4927 2.1849 0.0289 0.6135 RP11-23J18.1 13.6340 1.1754 0.5370 2.1888 0.0286 0.6135 TFR2 118.7950 1.2026 0.5498 2.1874 0.0287 0.6135 CD247 129.0981 1.2573 0.5747 2.1876 0.0287 0.6135 MOV10L1 181.0178 1.4311 0.6540 2.1883 0.0286 0.6135 RP13-39P12.2 146.6285 1.4683 0.6718 2.1855 0.0289 0.6135 RPL29P11 24.5766 1.6106 0.7363 2.1873 0.0287 0.6135 MYT1L 58.7975 2.2575 1.0316 2.1883 0.0286 0.6135 IGLV4-69 24.0147 2.6349 1.2053 2.1862 0.0288 0.6135 IGHD4-11 14.8886 2.8538 1.3056 2.1857 0.0288 0.6135 OR14I1 16.4656 3.1683 1.4492 2.1862 0.0288 0.6135 EDEM1 2477.7880 0.4865 0.2227 2.1842 0.0290 0.6136 SEC61A2 1578.7079 -0.7142 0.3271 -2.1830 0.0290 0.6147 FKBP4 3512.9076 -1.0522 0.4823 -2.1817 0.0291 0.6150 HMGN3 3435.9347 -0.4958 0.2272 -2.1824 0.0291 0.6150 FOXP3 165.9634 1.0587 0.4852 2.1820 0.0291 0.6150 AK1 22.9254 1.8084 0.8291 2.1812 0.0292 0.6151 MTRF1L 387.2213 -0.6059 0.2779 -2.1807 0.0292 0.6153 HSPB8 558.8509 1.1487 0.5268 2.1803 0.0292 0.6154 LAX1 115.9979 1.4402 0.6609 2.1792 0.0293 0.6164 TRIM43B 21.1159 -3.4298 1.5742 -2.1787 0.0294 0.6167 CARD16 479.1744 0.5901 0.2709 2.1781 0.0294 0.6170 RP11-726G1.1 313.9647 -1.4415 0.6631 -2.1740 0.0297 0.6201 AC002310.10 15.9309 -1.2001 0.5525 -2.1723 0.0298 0.6201 RPL6P2 21.1191 -0.8595 0.3958 -2.1715 0.0299 0.6201 DPY19L3 4744.9244 -0.8142 0.3749 -2.1715 0.0299 0.6201 CHEK2 1398.5356 -0.7927 0.3652 -2.1709 0.0299 0.6201 FAM168B 3177.6914 -0.5606 0.2580 -2.1727 0.0298 0.6201 ORC4 4336.4259 -0.5516 0.2540 -2.1711 0.0299 0.6201 USMG5 1687.0785 -0.4654 0.2140 -2.1745 0.0297 0.6201 BIRC3 4374.5456 0.9645 0.4440 2.1724 0.0298 0.6201 TNFRSF10A 398.0847 1.0017 0.4613 2.1712 0.0299 0.6201 LTK 36.1536 1.6100 0.7412 2.1722 0.0298 0.6201 NIM1K 30.5950 1.9958 0.9190 2.1718 0.0299 0.6201 GIPR 89.4348 2.1048 0.9696 2.1707 0.0300 0.6201 MIR514A1 15.1751 4.0973 1.8842 2.1745 0.0297 0.6201 IRG1 28.5056 2.0854 0.9612 2.1695 0.0300 0.6213 MAP1LC3C 18.0749 1.3728 0.6331 2.1683 0.0301 0.6226 PTCHD1 235.4042 2.3028 1.0627 2.1670 0.0302 0.6240 TIPARP 2142.0340 0.5068 0.2340 2.1664 0.0303 0.6244 CYYR1 847.7344 -1.5593 0.7200 -2.1659 0.0303 0.6246 LPHN2 11878.6262 -1.2777 0.5908 -2.1627 0.0306 0.6254 MELK 888.7102 -1.1001 0.5084 -2.1637 0.0305 0.6254 HEBP2 1470.9182 -0.7044 0.3256 -2.1630 0.0305 0.6254 TCEB3 2434.2539 -0.5809 0.2686 -2.1632 0.0305 0.6254 FAM194A 56.0593 1.4840 0.6857 2.1642 0.0304 0.6254 DAW1 77.3052 1.9709 0.9109 2.1638 0.0305 0.6254 SLC22A8 26.4455 3.5946 1.6609 2.1643 0.0304 0.6254 PPP2R5B 433.7845 0.7771 0.3595 2.1619 0.0306 0.6258 FOSL1 94.0500 1.4144 0.6543 2.1616 0.0306 0.6258 C7orf73 2316.6347 -0.6695 0.3101 -2.1590 0.0309 0.6272 ACOT11 844.9668 0.4167 0.1929 2.1604 0.0307 0.6272 CD96 352.3535 1.1137 0.5157 2.1594 0.0308 0.6272 CNTN2 79.7359 1.5351 0.7108 2.1596 0.0308 0.6272 TACR1 370.7006 1.5929 0.7378 2.1589 0.0309 0.6272 ARSA 496.3120 1.0176 0.4715 2.1584 0.0309 0.6273 TMEM176B 1399.8428 0.9615 0.4457 2.1572 0.0310 0.6286 ADTRP 158.9696 -1.9477 0.9059 -2.1501 0.0315 0.6293 KIAA1217 17468.4159 -0.8596 0.3989 -2.1549 0.0312 0.6293 TBCB 1030.5622 -0.8430 0.3910 -2.1559 0.0311 0.6293 CMAS 2150.8510 -0.8325 0.3864 -2.1542 0.0312 0.6293 FBXO18 3668.5634 -0.7317 0.3401 -2.1512 0.0315 0.6293 HOOK1 2997.7295 -0.6871 0.3196 -2.1500 0.0316 0.6293 ZMYND11 7996.9247 -0.6315 0.2930 -2.1557 0.0311 0.6293 FRMD4A 1641.2290 -0.5489 0.2550 -2.1529 0.0313 0.6293 HNRNPH3 5372.6943 -0.4954 0.2304 -2.1504 0.0315 0.6293 WIPF2 1296.9732 -0.4250 0.1975 -2.1519 0.0314 0.6293 TNFRSF10B 6279.8456 0.6303 0.2927 2.1531 0.0313 0.6293 LYST 10877.1153 0.7065 0.3280 2.1536 0.0313 0.6293 SPTBN4 310.0025 1.0180 0.4735 2.1500 0.0316 0.6293 LILRA6 76.9305 1.2436 0.5774 2.1537 0.0313 0.6293 SLAMF8 125.1927 1.2501 0.5811 2.1513 0.0315 0.6293 DISP2 75.7767 1.5443 0.7181 2.1506 0.0315 0.6293 OR1L1 39.4901 2.2583 1.0498 2.1512 0.0315 0.6293 OR10J1 13.2116 4.2909 1.9948 2.1511 0.0315 0.6293 TUBB4A 250.5159 1.9770 0.9198 2.1493 0.0316 0.6298 MIR181A2 20.6467 -1.0979 0.5110 -2.1485 0.0317 0.6304 CD3D 160.5280 1.4982 0.6975 2.1480 0.0317 0.6307 APOBEC3G 518.8494 0.7327 0.3412 2.1471 0.0318 0.6309 EFCAB9 27.1614 1.4671 0.6833 2.1472 0.0318 0.6309 SNORD93 31.1814 -1.1565 0.5392 -2.1449 0.0320 0.6309 MEX3B 205.5050 -1.1471 0.5345 -2.1460 0.0319 0.6309 RMND1 2459.9814 -0.7574 0.3530 -2.1453 0.0319 0.6309 ERLIN1 2174.9770 -0.5145 0.2398 -2.1456 0.0319 0.6309 CTC-287O8.1 30.6806 1.2839 0.5982 2.1462 0.0319 0.6309 OR7E55P 14.0164 2.4834 1.1577 2.1451 0.0319 0.6309 MFNG 101.1890 1.0815 0.5043 2.1444 0.0320 0.6311 HNRNPA0 4064.0538 -0.5339 0.2490 -2.1439 0.0320 0.6314 BCAS4 111.3263 1.1093 0.5176 2.1433 0.0321 0.6317 UNG 2259.7108 -0.6175 0.2882 -2.1426 0.0321 0.6323 CKS1B 410.1126 -0.7526 0.3518 -2.1392 0.0324 0.6334 MRPL19 2058.4013 -0.5454 0.2548 -2.1410 0.0323 0.6334 WDFY2 1178.7259 -0.4970 0.2323 -2.1394 0.0324 0.6334 STC1 764.1136 1.1102 0.5186 2.1408 0.0323 0.6334 ANGPTL6 47.2146 1.2999 0.6077 2.1389 0.0324 0.6334 CPNE6 89.4260 1.3585 0.6353 2.1385 0.0325 0.6334 CLEC10A 90.4313 1.4782 0.6911 2.1389 0.0324 0.6334 EGLN3 897.7554 1.6515 0.7718 2.1399 0.0324 0.6334 C1orf227 14.5110 1.7937 0.8380 2.1405 0.0323 0.6334 GSTA5 12.1691 -3.5377 1.6557 -2.1368 0.0326 0.6337 GOLGA8B 789.8047 -1.2758 0.5975 -2.1353 0.0327 0.6337 FASTKD1 1846.6243 -0.6878 0.3218 -2.1375 0.0326 0.6337 MPDZ 5811.4604 -0.6726 0.3151 -2.1350 0.0328 0.6337 CAAP1 1363.9927 -0.4893 0.2289 -2.1376 0.0326 0.6337 WDR44 1977.6639 0.5039 0.2358 2.1371 0.0326 0.6337 BHLHE40 2155.3239 0.9859 0.4617 2.1351 0.0328 0.6337 KLK13 99.1567 1.6746 0.7843 2.1353 0.0327 0.6337 DLX1 20.4526 2.8624 1.3405 2.1353 0.0327 0.6337 SDSL 196.3334 0.9013 0.4224 2.1337 0.0329 0.6344 KCNN1 73.5022 1.3547 0.6350 2.1335 0.0329 0.6344 PTK6 191.1176 1.6857 0.7901 2.1336 0.0329 0.6344 CBLN2 32.3923 -4.4469 2.0847 -2.1331 0.0329 0.6345 AMPD3 1212.7510 0.6345 0.2976 2.1324 0.0330 0.6350 NDUFS7 276.5668 0.5873 0.2755 2.1320 0.0330 0.6351 CYP3A7 671.9719 0.5296 0.2484 2.1315 0.0330 0.6353 CCDC181 371.9606 -0.8509 0.3993 -2.1310 0.0331 0.6356 PLCXD2 48.1963 1.1794 0.5537 2.1300 0.0332 0.6360 SLC6A11 186.3415 1.5449 0.7253 2.1300 0.0332 0.6360 GPR142 9.9171 3.3871 1.5905 2.1295 0.0332 0.6361 CST1 333.9788 -2.6223 1.2318 -2.1288 0.0333 0.6367 TESPA1 189.6875 1.4446 0.6787 2.1284 0.0333 0.6367 IFT74 1810.1323 -0.6314 0.2971 -2.1251 0.0336 0.6381 TMEM97 706.6512 -0.5247 0.2469 -2.1251 0.0336 0.6381 GREM2 55.4106 1.8815 0.8850 2.1259 0.0335 0.6381 GOLGA8S 25.6551 1.8887 0.8881 2.1267 0.0334 0.6381 RP11-402G3.3 12.4736 1.9612 0.9229 2.1250 0.0336 0.6381 CCDC144NL 18.2836 2.3178 1.0897 2.1269 0.0334 0.6381 CDK5R2 9.4541 2.8150 1.3243 2.1256 0.0335 0.6381 C2orf88 6043.4952 -1.1307 0.5326 -2.1231 0.0337 0.6394 SCUBE3 1221.1115 -0.8763 0.4129 -2.1222 0.0338 0.6394 RGL2 1937.9458 -0.8688 0.4093 -2.1226 0.0338 0.6394 SAMD4B 2825.8282 -0.7127 0.3361 -2.1206 0.0340 0.6394 TMEM39B 539.6329 -0.6816 0.3213 -2.1217 0.0339 0.6394 TMEM69 1355.8119 -0.6217 0.2930 -2.1219 0.0338 0.6394 BCAS2 1747.6850 -0.4210 0.1982 -2.1238 0.0337 0.6394 RAB1A 5696.7292 -0.3446 0.1623 -2.1228 0.0338 0.6394 MST1P2 210.8024 0.8043 0.3792 2.1211 0.0339 0.6394 RP3-497J21.1 27.8408 2.1551 1.0161 2.1208 0.0339 0.6394 RFX3 5509.0189 -0.5018 0.2367 -2.1202 0.0340 0.6395 SBK1 292.7109 -1.1395 0.5388 -2.1148 0.0344 0.6396 CDK6 6423.6380 -1.1333 0.5353 -2.1171 0.0343 0.6396 GRAMD1C 903.2237 -0.9367 0.4424 -2.1172 0.0342 0.6396 RALA 2091.3400 -0.6591 0.3114 -2.1162 0.0343 0.6396 DUSP11 2211.1620 -0.6016 0.2841 -2.1174 0.0342 0.6396 SNRNP27 665.8604 -0.5681 0.2686 -2.1155 0.0344 0.6396 RASAL2 3997.5348 -0.3807 0.1797 -2.1182 0.0342 0.6396 TRIP10 1127.9142 0.4709 0.2224 2.1174 0.0342 0.6396 EXTL3 2313.4295 0.6472 0.3060 2.1149 0.0344 0.6396 KB-1205A7.1 59.5247 1.0399 0.4910 2.1181 0.0342 0.6396 IGSF22 108.3492 1.1680 0.5517 2.1170 0.0343 0.6396 PRKXP1 24.2157 1.3154 0.6217 2.1159 0.0344 0.6396 JSRP1 16.4945 2.2237 1.0509 2.1160 0.0343 0.6396 AADACL3 14.2527 3.7418 1.7683 2.1160 0.0343 0.6396 OR2B3 10.9665 3.9685 1.8727 2.1192 0.0341 0.6396 OR9A1P 15.8625 -1.7532 0.8308 -2.1103 0.0348 0.6423 NSG1 1449.0472 -1.2394 0.5873 -2.1104 0.0348 0.6423 DBT 3673.0017 -0.4745 0.2248 -2.1104 0.0348 0.6423 SMARCD3 1284.8234 1.0398 0.4923 2.1121 0.0347 0.6423 SAMD3 170.7736 1.1414 0.5409 2.1104 0.0348 0.6423 PTPRN 33.5889 1.8916 0.8958 2.1117 0.0347 0.6423 AC079781.8 16.0986 2.2865 1.0831 2.1111 0.0348 0.6423 CD70 12.5003 2.5055 1.1868 2.1112 0.0348 0.6423 EIF4BP2 18.7036 -1.9440 0.9223 -2.1079 0.0350 0.6440 NME4 471.5675 -0.7584 0.3597 -2.1084 0.0350 0.6440 ATXN2L 8095.2320 -0.6464 0.3068 -2.1068 0.0351 0.6440 POLE 2580.9805 -0.5036 0.2388 -2.1085 0.0350 0.6440 CCL5 455.5741 1.2524 0.5945 2.1068 0.0351 0.6440 FSD1 49.3728 1.6193 0.7685 2.1072 0.0351 0.6440 KRT24 22.0653 6.3811 3.0288 2.1068 0.0351 0.6440 CTSS 2232.5737 0.9209 0.4373 2.1059 0.0352 0.6441 CX3CL1 228.2498 1.1067 0.5256 2.1057 0.0352 0.6441 KCNH4 46.2322 1.9411 0.9218 2.1058 0.0352 0.6441 ST3GAL6 1302.6997 -0.7838 0.3723 -2.1052 0.0353 0.6444 SNORD115-29 15.4072 4.1323 1.9634 2.1047 0.0353 0.6446 TMEM208 216.5049 0.6727 0.3199 2.1030 0.0355 0.6462 NMD3P1 26.3110 1.2563 0.5973 2.1033 0.0354 0.6462 POMT1 2221.2730 0.3484 0.1657 2.1025 0.0355 0.6464 OR8B2 41.2216 -4.0260 1.9154 -2.1019 0.0356 0.6468 SYP 75.0688 1.1612 0.5527 2.1010 0.0356 0.6476 CALHM1 23.3213 2.4549 1.1686 2.1007 0.0357 0.6476 SERPINC1 42.8017 1.8854 0.8977 2.1003 0.0357 0.6477 TXNDC12 1668.7823 -0.6605 0.3146 -2.0992 0.0358 0.6487 FAM81B 154.5691 1.7098 0.8146 2.0990 0.0358 0.6487 OSTCP8 92.8133 -0.7307 0.3483 -2.0981 0.0359 0.6489 MTBP 1435.1829 -0.7041 0.3357 -2.0973 0.0360 0.6489 ANKRD16 437.4321 -0.5712 0.2724 -2.0973 0.0360 0.6489 TMED4 2614.8627 -0.5352 0.2552 -2.0972 0.0360 0.6489 APOL5 13.5742 2.4810 1.1827 2.0977 0.0359 0.6489 ASB13 256.1239 -0.7986 0.3809 -2.0962 0.0361 0.6496 PAICS 4040.8284 -0.7514 0.3585 -2.0957 0.0361 0.6496 RTN4RL2 28.9086 1.0212 0.4873 2.0958 0.0361 0.6496 C15orf41 575.1000 0.4664 0.2226 2.0947 0.0362 0.6500 RP11-460N11.2 40.1473 1.4127 0.6743 2.0950 0.0362 0.6500 SLC34A3 122.4440 1.3756 0.6571 2.0934 0.0363 0.6507 GOLGA8M 364.8608 1.6140 0.7709 2.0937 0.0363 0.6507 RP11-652G5.1 10.7905 5.0678 2.4210 2.0933 0.0363 0.6507 FMN1 3474.6032 0.9237 0.4415 2.0924 0.0364 0.6515 TM4SF19-AS1 10.9786 2.3095 1.1040 2.0920 0.0364 0.6516 RPL9P32 1678.2501 -0.8420 0.4026 -2.0916 0.0365 0.6517 TCEA2 653.0896 -0.6843 0.3273 -2.0905 0.0366 0.6519 CCR5 279.6312 1.0549 0.5046 2.0905 0.0366 0.6519 CKM 28.2215 1.4171 0.6779 2.0904 0.0366 0.6519 ARHGAP30 1041.0584 0.6903 0.3304 2.0897 0.0366 0.6519 OR6T1 19.0162 3.3528 1.6042 2.0901 0.0366 0.6519 ISX 14.7189 3.5463 1.6973 2.0894 0.0367 0.6519 RP11-1267H10.4 49.1188 -6.3695 3.0499 -2.0884 0.0368 0.6520 GPC4 1531.8950 -1.1064 0.5298 -2.0883 0.0368 0.6520 EXOSC3 1019.0562 -0.7684 0.3680 -2.0883 0.0368 0.6520 PCDHGB2 260.1255 0.7214 0.3455 2.0880 0.0368 0.6520 DSCC1 772.7073 -0.8231 0.3943 -2.0874 0.0369 0.6524 IL17RB 575.2166 -0.5309 0.2544 -2.0869 0.0369 0.6526 DPH1 953.5295 0.6110 0.2928 2.0866 0.0369 0.6526 DUS3L 401.9719 0.5942 0.2849 2.0860 0.0370 0.6530 ZNF891 1125.1216 -1.0037 0.4818 -2.0829 0.0373 0.6558 LGALS9 1408.3711 0.7076 0.3397 2.0833 0.0372 0.6558 ZNF324B 228.4513 0.7407 0.3556 2.0832 0.0372 0.6558 RP11-435B5.5 246.3114 1.2246 0.5877 2.0838 0.0372 0.6558 UBE2D4 317.1758 -0.4606 0.2212 -2.0821 0.0373 0.6565 NXF2 13.9610 -5.4409 2.6168 -2.0793 0.0376 0.6574 JAG2 991.7636 -0.8955 0.4303 -2.0811 0.0374 0.6574 ZRANB3 1130.5612 -0.5245 0.2523 -2.0794 0.0376 0.6574 ADAP1 87.8354 1.3094 0.6293 2.0807 0.0375 0.6574 GZMK 18.9034 1.7334 0.8333 2.0801 0.0375 0.6574 EPHA5 118.8102 1.9369 0.9313 2.0799 0.0375 0.6574 INSM2 28.6891 2.3948 1.1512 2.0803 0.0375 0.6574 NPRL3 1289.3373 -0.5633 0.2710 -2.0781 0.0377 0.6587 AKIRIN1 3060.8332 -0.8867 0.4268 -2.0777 0.0377 0.6588 UBAP2 5693.4337 -0.6141 0.2957 -2.0769 0.0378 0.6595 PLEKHA5 9391.3765 -1.0196 0.4911 -2.0761 0.0379 0.6597 ZNF507 4431.7315 -0.8997 0.4333 -2.0764 0.0379 0.6597 FGF17 89.9251 -2.3499 1.1322 -2.0756 0.0379 0.6600 LA16c-3G11.7 111.4230 -4.9069 2.3645 -2.0752 0.0380 0.6601 ZNF300P1 124.4079 -1.3219 0.6375 -2.0736 0.0381 0.6611 CSRNP3 1776.8843 -0.8418 0.4059 -2.0740 0.0381 0.6611 RPS15AP10 59.8770 -0.6403 0.3089 -2.0729 0.0382 0.6611 PCBP4 523.3737 0.8614 0.4154 2.0735 0.0381 0.6611 CELA2A 23.8861 1.7650 0.8515 2.0729 0.0382 0.6611 ALG10 1364.6456 -0.4919 0.2374 -2.0724 0.0382 0.6614 ZFP14 1417.4979 -0.5884 0.2841 -2.0715 0.0383 0.6622 PAGE2B 60.1208 -2.6353 1.2736 -2.0692 0.0385 0.6636 ITFG3 205.5628 -0.9923 0.4798 -2.0683 0.0386 0.6636 AUTS2 4120.7681 -0.6692 0.3235 -2.0686 0.0386 0.6636 SBNO2 1821.8046 0.8550 0.4131 2.0698 0.0385 0.6636 C11orf63 472.4655 1.0748 0.5196 2.0685 0.0386 0.6636 KIF26A 59.8071 1.4985 0.7241 2.0695 0.0385 0.6636 FAT2 5060.2539 1.9096 0.9224 2.0703 0.0384 0.6636 PEX13 2300.0598 -0.5089 0.2462 -2.0669 0.0387 0.6654 SLC18A1 37.2653 3.8403 1.8584 2.0665 0.0388 0.6656 MYCN 448.1144 -1.3867 0.6715 -2.0649 0.0389 0.6661 TAS2R3 729.2610 -0.6294 0.3047 -2.0656 0.0389 0.6661 IL1RAPL2 173.1993 1.8497 0.8956 2.0654 0.0389 0.6661 PTF1A 30.8248 5.7121 2.7664 2.0648 0.0389 0.6661 RP11-111M22.2 248.1130 -0.8535 0.4135 -2.0641 0.0390 0.6667 AQP9 372.5325 1.5402 0.7465 2.0633 0.0391 0.6675 IL18RAP 43.4149 1.5822 0.7673 2.0620 0.0392 0.6691 SLC15A2 1676.7118 -0.9890 0.4800 -2.0604 0.0394 0.6700 SMARCA4 14491.5730 -0.7734 0.3753 -2.0610 0.0393 0.6700 WDR35 4324.1304 -0.3597 0.1746 -2.0606 0.0393 0.6700 CD86 247.0154 0.8714 0.4230 2.0599 0.0394 0.6703 OSMR 4308.6984 0.9113 0.4425 2.0596 0.0394 0.6703 PIAS2 5302.6503 -0.4440 0.2156 -2.0593 0.0395 0.6703 CYP11B2 25.2346 6.2196 3.0212 2.0587 0.0395 0.6707 LRRC37A15P 124.8943 0.7876 0.3828 2.0574 0.0396 0.6723 RFC3 1399.1555 -0.8147 0.3968 -2.0532 0.0401 0.6761 MRPS10 482.5218 -0.6647 0.3236 -2.0542 0.0400 0.6761 ZNF326 3121.7124 -0.4313 0.2100 -2.0533 0.0400 0.6761 REPS1 3853.2033 -0.4170 0.2030 -2.0540 0.0400 0.6761 CTSE 60.2014 1.8619 0.9065 2.0539 0.0400 0.6761 TH 19.7944 2.3339 1.1368 2.0531 0.0401 0.6761 PLCB2 753.9303 0.8331 0.4060 2.0518 0.0402 0.6771 CDHR2 117.6121 1.9250 0.9381 2.0519 0.0402 0.6771 CTRC 20.0321 1.6308 0.7950 2.0512 0.0402 0.6776 APOC1 236.9497 1.0399 0.5071 2.0507 0.0403 0.6779 SLBP 2304.1267 -0.7203 0.3515 -2.0492 0.0404 0.6789 JAKMIP1 99.0598 1.1337 0.5533 2.0491 0.0405 0.6789 ASB15 31.8415 1.7384 0.8483 2.0493 0.0404 0.6789 RPS27A 37904.7388 -0.6530 0.3188 -2.0482 0.0405 0.6798 RTEL1P1 32.9846 1.1334 0.5539 2.0464 0.0407 0.6821 GBX1 27.0366 1.8966 0.9269 2.0462 0.0407 0.6821 ANKRD62 79.5770 -2.5860 1.2654 -2.0437 0.0410 0.6823 MKRN3 190.2977 -2.3816 1.1674 -2.0401 0.0413 0.6823 HTRA1 6117.0147 -0.9391 0.4604 -2.0398 0.0414 0.6823 DCAF12 2495.4202 -0.6915 0.3389 -2.0405 0.0413 0.6823 ZNF682 1538.7829 -0.6849 0.3358 -2.0396 0.0414 0.6823 MXI1 2163.4761 -0.6422 0.3144 -2.0422 0.0411 0.6823 GEN1 2254.8425 -0.5686 0.2781 -2.0446 0.0409 0.6823 GGCX 2753.9674 -0.5592 0.2740 -2.0412 0.0412 0.6823 FANCG 1248.9245 -0.4894 0.2399 -2.0401 0.0413 0.6823 SIRT6 115.5155 0.8714 0.4267 2.0421 0.0411 0.6823 LETM2 354.9497 0.8847 0.4328 2.0442 0.0409 0.6823 PTENP1 72.9199 1.0659 0.5227 2.0392 0.0414 0.6823 MUC12 1031.1637 1.6184 0.7930 2.0409 0.0413 0.6823 IGJ 1466.3766 1.6218 0.7953 2.0393 0.0414 0.6823 FAM180B 30.5225 1.7304 0.8482 2.0401 0.0413 0.6823 AC136604.1 12.7713 1.9075 0.9354 2.0392 0.0414 0.6823 IGHV1OR15-1 27.3555 1.9202 0.9413 2.0400 0.0413 0.6823 S1PR5 17.3692 2.3677 1.1587 2.0434 0.0410 0.6823 RP11-188C12.3 14.9443 2.4155 1.1832 2.0415 0.0412 0.6823 SYNGR4 10.0090 2.8328 1.3893 2.0389 0.0415 0.6823 HOXC11 16.3215 2.9482 1.4443 2.0413 0.0412 0.6823 SLC13A2 39.8074 3.2770 1.6059 2.0406 0.0413 0.6823 UBE2U 59.2502 -2.5538 1.2528 -2.0384 0.0415 0.6826 TRPC3 56.5620 1.3615 0.6681 2.0377 0.0416 0.6828 RNASE8 33.2838 1.5402 0.7559 2.0377 0.0416 0.6828 CD300LF 63.8796 1.4601 0.7167 2.0373 0.0416 0.6829 SPIN2B 353.3346 0.5119 0.2514 2.0363 0.0417 0.6837 DUSP8 177.1814 1.1460 0.5628 2.0361 0.0417 0.6837 RFESD 65.8887 1.4532 0.7138 2.0357 0.0418 0.6839 ZCCHC5 17.7063 2.2189 1.0903 2.0350 0.0418 0.6840 AC140481.2 20.2577 2.5659 1.2607 2.0353 0.0418 0.6840 UBE2D3P2 41.4841 0.9893 0.4863 2.0344 0.0419 0.6844 TUBA3GP 11.9985 4.2693 2.0996 2.0334 0.0420 0.6857 RP11-9L18.2 55.2042 2.2334 1.0987 2.0329 0.0421 0.6859 KCNJ15 84.0644 1.4188 0.6984 2.0315 0.0422 0.6877 OR1A1 10.9321 4.3127 2.1232 2.0312 0.0422 0.6877 SAMD5 288.4877 -1.1742 0.5795 -2.0261 0.0428 0.6897 RP11-154D3.1 15.9184 -1.0353 0.5109 -2.0264 0.0427 0.6897 C6orf106 1832.0180 -0.6207 0.3059 -2.0291 0.0425 0.6897 RANBP3 1339.9342 0.4350 0.2145 2.0285 0.0425 0.6897 CBX7 354.2337 0.7967 0.3931 2.0268 0.0427 0.6897 CTAGE5 108.8907 0.8309 0.4096 2.0286 0.0425 0.6897 TNFRSF1B 373.4385 0.8685 0.4283 2.0278 0.0426 0.6897 AL627309.1 4426.5290 0.9047 0.4461 2.0281 0.0426 0.6897 TMEM63C 323.8881 0.9903 0.4884 2.0277 0.0426 0.6897 HRH2 121.4703 1.4016 0.6913 2.0276 0.0426 0.6897 RPL13AP3 10.0835 1.6919 0.8346 2.0273 0.0426 0.6897 RP3-417G15.1 26.6333 1.8827 0.9292 2.0262 0.0427 0.6897 SLC10A2 58.5164 2.5284 1.2483 2.0254 0.0428 0.6904 TBPL1 594.0380 -0.5838 0.2884 -2.0245 0.0429 0.6914 HLA-DPA1 4382.4214 0.7782 0.3845 2.0240 0.0430 0.6916 CRYGA 10.1836 -4.7010 2.3239 -2.0229 0.0431 0.6920 ZNF723 206.0981 -4.3841 2.1700 -2.0203 0.0434 0.6920 FBL 3454.9556 -0.8534 0.4225 -2.0200 0.0434 0.6920 BAG6 5307.5787 -0.8387 0.4145 -2.0232 0.0431 0.6920 ADAT2 861.7376 -0.7555 0.3738 -2.0214 0.0432 0.6920 LANCL2 1031.4699 -0.4860 0.2404 -2.0214 0.0432 0.6920 NDUFAF1 893.3866 0.4393 0.2174 2.0205 0.0433 0.6920 RAB27A 1339.1139 0.5894 0.2916 2.0214 0.0432 0.6920 PRDM8 112.8328 1.2672 0.6266 2.0222 0.0432 0.6920 RNY1 68.1779 1.3830 0.6844 2.0209 0.0433 0.6920 BEX5 73.0414 1.5949 0.7886 2.0225 0.0431 0.6920 ZCCHC13 13.1049 4.8242 2.3874 2.0207 0.0433 0.6920 NCBP2 8291.8175 -0.9840 0.4872 -2.0196 0.0434 0.6921 YPEL4 825.3642 -0.6031 0.2988 -2.0185 0.0435 0.6930 SNORA47 134.7901 0.9394 0.4655 2.0179 0.0436 0.6930 CD74 19235.0831 0.9715 0.4812 2.0187 0.0435 0.6930 SNORA40 24.3517 1.1657 0.5777 2.0179 0.0436 0.6930 HIST1H2AE 1111.4107 -0.8906 0.4420 -2.0147 0.0439 0.6932 UQCRH 4713.4257 -0.7551 0.3748 -2.0149 0.0439 0.6932 ATP2B1 9353.6938 -0.5901 0.2928 -2.0154 0.0439 0.6932 TTN 21815.4214 0.4297 0.2131 2.0161 0.0438 0.6932 GLRA1 90.2858 1.0164 0.5041 2.0162 0.0438 0.6932 ARRDC2 222.4639 1.1085 0.5501 2.0152 0.0439 0.6932 ANO5 731.9539 1.1411 0.5660 2.0163 0.0438 0.6932 DYNLL1P1 26.6036 1.8649 0.9258 2.0145 0.0440 0.6932 CPA1 40.6166 2.1550 1.0685 2.0169 0.0437 0.6932 SFRP2 736.8723 2.4280 1.2054 2.0143 0.0440 0.6932 FBXO40 42.4305 2.6877 1.3328 2.0167 0.0437 0.6932 MIR197 17.3073 1.2253 0.6086 2.0133 0.0441 0.6938 KCNJ10 90.5685 1.2741 0.6328 2.0134 0.0441 0.6938 TYW3 1205.1147 -0.5722 0.2844 -2.0119 0.0442 0.6946 BMS1P10 162.7683 0.6793 0.3376 2.0120 0.0442 0.6946 PCDHA12 298.0497 1.1124 0.5530 2.0116 0.0443 0.6946 RP11-433C9.2 8.8650 2.6674 1.3255 2.0124 0.0442 0.6946 UNC119B 889.6142 -0.6190 0.3078 -2.0107 0.0444 0.6950 CHMP5 1476.8807 -0.5170 0.2572 -2.0105 0.0444 0.6950 TXNDC9 897.8202 -0.3339 0.1661 -2.0104 0.0444 0.6950 ATF7IP2 1720.5167 -0.6479 0.3224 -2.0095 0.0445 0.6960 NEBL 2389.2967 -0.8028 0.3996 -2.0089 0.0445 0.6960 TTC40 379.5865 1.5673 0.7802 2.0087 0.0446 0.6960 RP11-875O11.2 15.6418 2.4885 1.2389 2.0086 0.0446 0.6960 RBCK1 1830.6050 0.8017 0.3993 2.0078 0.0447 0.6963 P2RX1 106.0358 1.2029 0.5990 2.0081 0.0446 0.6963 DGUOK 1639.9357 -0.5204 0.2595 -2.0052 0.0449 0.6995 PWWP2A 2684.6212 0.5090 0.2539 2.0049 0.0450 0.6995 SLC7A6OS 136.4255 0.5323 0.2655 2.0047 0.0450 0.6995 ADAM8 379.6819 0.8772 0.4376 2.0047 0.0450 0.6995 RAB9A 358.7223 0.4120 0.2056 2.0042 0.0450 0.6997 RP4-765C7.2 12.4050 1.8744 0.9358 2.0029 0.0452 0.7013 CYP11A1 815.5080 -1.6241 0.8114 -2.0017 0.0453 0.7029 TET1 2776.4754 -0.7650 0.3824 -2.0004 0.0455 0.7030 SSX2IP 1832.4189 -0.5963 0.2981 -2.0003 0.0455 0.7030 CDKN2D 86.0065 0.8147 0.4072 2.0007 0.0454 0.7030 RIMBP2 895.8543 1.3839 0.6919 2.0001 0.0455 0.7030 C10orf40 51.4963 2.4750 1.2370 2.0008 0.0454 0.7030 CEP68 3367.4796 -0.4986 0.2493 -1.9997 0.0455 0.7032 GADD45G 78.5272 0.8834 0.4419 1.9992 0.0456 0.7035 UNC13D 945.8026 0.7954 0.3981 1.9977 0.0457 0.7049 AADACL4 12.6158 2.3505 1.1766 1.9977 0.0457 0.7049 AC016831.7 16.6058 1.4929 0.7475 1.9973 0.0458 0.7051 MTPAP 4805.1699 -0.5547 0.2778 -1.9965 0.0459 0.7059 GCHFR 65.7619 1.0987 0.5505 1.9956 0.0460 0.7066 TENM1 519.3365 1.4904 0.7469 1.9955 0.0460 0.7066 ZDHHC6 2094.0311 -0.5509 0.2762 -1.9948 0.0461 0.7073 IL13RA2 68.2068 -2.7361 1.3719 -1.9944 0.0461 0.7074 FAM84A 454.5707 -1.1673 0.5856 -1.9933 0.0462 0.7079 OXR1 5806.7314 -0.8039 0.4033 -1.9932 0.0462 0.7079 GHDC 189.7507 0.5288 0.2652 1.9936 0.0462 0.7079 LY6G6C 70.4711 -1.6982 0.8523 -1.9925 0.0463 0.7085 GOLGA8I 234.4189 1.3938 0.6997 1.9921 0.0464 0.7087 KIFC1 757.1412 -1.2344 0.6197 -1.9918 0.0464 0.7088 HOXC8 164.8745 1.2709 0.6386 1.9902 0.0466 0.7090 AC079210.1 19.0534 1.3238 0.6652 1.9901 0.0466 0.7090 BRSK2 134.6938 1.5950 0.8011 1.9909 0.0465 0.7090 SIGLEC14 34.8899 1.6102 0.8086 1.9913 0.0464 0.7090 GPR88 21.8642 1.9666 0.9881 1.9902 0.0466 0.7090 ICA1 1671.7239 -0.6160 0.3097 -1.9889 0.0467 0.7099 ZNF778 307.3086 0.5286 0.2659 1.9883 0.0468 0.7099 RP11-39K24.9 116.5921 0.7551 0.3799 1.9877 0.0468 0.7099 ARHGAP4 1031.8508 0.9152 0.4602 1.9888 0.0467 0.7099 ITGAE 334.4089 1.0030 0.5047 1.9875 0.0469 0.7099 PRKCB 351.4393 1.2126 0.6098 1.9883 0.0468 0.7099 ARMS2 23.4707 2.0534 1.0329 1.9879 0.0468 0.7099 EMR3 47.7490 2.2723 1.1437 1.9867 0.0470 0.7107 USP49 1135.6341 -0.4318 0.2176 -1.9843 0.0472 0.7133 SLC2A6 105.5056 0.9380 0.4727 1.9845 0.0472 0.7133 ANKRD20A17P 58.2638 1.7695 0.8917 1.9845 0.0472 0.7133 TONSL 877.1805 -0.9531 0.4806 -1.9834 0.0473 0.7137 PARD6A 56.4071 0.9588 0.4833 1.9837 0.0473 0.7137 RP11-473N11.2 284.5234 -1.2768 0.6444 -1.9815 0.0475 0.7142 HIST1H3B 674.9427 -1.2262 0.6195 -1.9795 0.0478 0.7142 SKIDA1 419.3081 -0.9580 0.4832 -1.9824 0.0474 0.7142 RPL13AP20 40.9124 -0.8858 0.4475 -1.9797 0.0477 0.7142 POLR2D 706.0684 -0.5482 0.2769 -1.9799 0.0477 0.7142 UBE4B 7407.6443 -0.4603 0.2324 -1.9807 0.0476 0.7142 EFCAB12 128.6491 1.1567 0.5842 1.9801 0.0477 0.7142 GRIN3A 136.7438 1.4259 0.7196 1.9814 0.0476 0.7142 AC073109.2 39.1334 1.6292 0.8218 1.9825 0.0474 0.7142 CXorf28 9.5915 1.7018 0.8591 1.9809 0.0476 0.7142 IGHV2-5 168.3884 2.6291 1.3280 1.9797 0.0477 0.7142 F9 17.6369 2.8145 1.4206 1.9813 0.0476 0.7142 ITLN2 19.3343 1.8821 0.9511 1.9788 0.0478 0.7149 NUDT19 1417.6863 -1.0267 0.5193 -1.9769 0.0480 0.7175 GPANK1 169.1957 -0.7299 0.3693 -1.9764 0.0481 0.7179 SNX20 77.2308 1.1075 0.5608 1.9750 0.0483 0.7195 IGLL1 11.7247 3.6481 1.8472 1.9749 0.0483 0.7195 FAM171A2 293.1993 -1.3346 0.6765 -1.9729 0.0485 0.7219 FLJ27365 858.4660 0.8041 0.4076 1.9728 0.0485 0.7219 C19orf18 89.3046 0.9701 0.4918 1.9725 0.0486 0.7220 RPL13AP25 110.3584 0.7429 0.3769 1.9711 0.0487 0.7234 RP11-563J2.2 58.7181 0.9588 0.4864 1.9713 0.0487 0.7234 C20orf195 53.9204 1.1741 0.5960 1.9699 0.0489 0.7234 PLVAP 334.8653 1.1812 0.5994 1.9707 0.0488 0.7234 TYMP 1107.7688 1.2036 0.6110 1.9699 0.0489 0.7234 THEMIS 157.2890 1.2385 0.6287 1.9700 0.0488 0.7234 C6orf136 547.6872 -0.6231 0.3164 -1.9694 0.0489 0.7237 LRRFIP1 6268.7791 0.7654 0.3889 1.9679 0.0491 0.7245 RARRES1 1129.7524 0.9953 0.5059 1.9675 0.0491 0.7245 SLC35F4 40.5347 1.4033 0.7131 1.9678 0.0491 0.7245 GUCY1A2 2072.3217 1.4387 0.7309 1.9684 0.0490 0.7245 CASC4P1 15.3755 1.4645 0.7445 1.9672 0.0492 0.7245 NLRP10 20.1540 3.8872 1.9753 1.9679 0.0491 0.7245 MTCH1 4624.0187 -0.6947 0.3535 -1.9653 0.0494 0.7246 GPR75 659.4597 -0.5142 0.2616 -1.9658 0.0493 0.7246 GNRH2 38.1305 1.0418 0.5299 1.9662 0.0493 0.7246 CCDC27 57.5679 1.2762 0.6491 1.9662 0.0493 0.7246 KRT8P43 10.6557 2.3210 1.1809 1.9654 0.0494 0.7246 GABRR1 119.0217 2.3858 1.2138 1.9656 0.0493 0.7246 FAM32A 955.7530 -0.5911 0.3009 -1.9646 0.0495 0.7249 DEFB126 33.3498 2.2638 1.1525 1.9643 0.0495 0.7249 HSP90B3P 9.8929 3.6454 1.8554 1.9648 0.0494 0.7249 LRRC41 3648.1590 -0.6940 0.3533 -1.9640 0.0495 0.7250 CLTB 852.9744 0.8338 0.4249 1.9621 0.0498 0.7277 SNHG16 1550.6042 -0.5919 0.3018 -1.9613 0.0498 0.7282 RHOU 2635.8877 -0.5638 0.2876 -1.9607 0.0499 0.7282 RP11-350G8.7 37.2937 0.8365 0.4267 1.9606 0.0499 0.7282 CACNG8 34.7368 1.5001 0.7650 1.9608 0.0499 0.7282

Supplemental Table 7. Genes differentially represented in TIM-3Hi vs TIM-3Lo HGSCs.

ImmuneHi/TIM-3Hi vs ImmuneHi/TIM-3Lo ImmuneLo/TIM-3Hi vs ImmuneLo/TIM-3Lo PD-1 p =0.565 p =0.426 LAG-3 p =0.567 p =0.322 CTLA4 p =0.091 p =0.245 PD-L1 p =0.225 p =0.720 CD8 p =0.284 p =0.076 DCLAMP p =0.412 p =0.853 CD20 p =0.363 p =0.722

Supplemental Table 8. Results of biostatistic analysis comparing expression of PD-L1 and density of PD-1+, LAG-3+, CTLA4+, CD8+, DC-LAMP+ and CD20+ cells in tumor microenvironment of ImmuneHi/TIM-3Hi vs ImmuneHi/TIM-3Lo and ImmuneLo/TIM-3Hi vs ImmuneLo/TIM-3Lo.