Pnas10940toc 3..9

October 2, 2012 u vol. 109 u no. 40 u 15967–16394

Cover image: Pictured are hair-like structures known as trichomes on a tomato leaf. Trichomes coat the surfaces of many plants and produce a variety of specialized chemicals, some of which help protect plants from insects and herbivores. Anthony L. Schilmiller et al. identified an enzyme expressed in the tip cell of long trichomes that participates in the synthesis of protective acyl sugars secreted to the surface of tomato plants. According to the authors, the findings could help researchers develop pest-resistant plants. See the article by Schilmiller et al. on pages 16377–16382. Image courtesy of Anthony L. Schilmiller. From the Cover

16377 Sugar synthesis in tomato trichomes 15980 Long-term effects of cannabis 16113 Regulation of microtubule dynamics 16184 Dissecting a rat insulin pathway 16213 Census of deep seabed microbes

Contents QNAS 15969 QnAs with Subra Suresh Prashant Nair THIS WEEK IN PNAS

15967 In This Issue COMMENTARIES

15970 Long-term effects of adolescent-onset and persistent LETTERS (ONLINE ONLY) use of cannabis Raul Gonzalez and James M. Swanson See companion article on pages E2657 and 15980 E2645 India-Asia collision timing Jonathan C. Aitchison and Jason R. Ali 15972 Complications dawn for kinetochore regulation by Aurora Natalie J. Nannas and Andrew W. Murray E2646 Reply to Aitchison and Ali: Reconciling Himalayan See companion article on page 16113 ophiolite and Asian magmatic arc records with a two-stage India-Asia collision model 15974 Distinct mTORC1 pathways for transcription and Douwe J. J. van Hinsbergen, Peter C. Lippert, Guillaume cleavage of SREBP-1c Dupont-Nivet, Nadine McQuarrie, Pavel V. Doubrovine, William J. Quinn III and Morris J. Birnbaum Wim Spakman, and Trond H. Torsvik See companion article on page 16184 E2647 Location of natural oil seep and chemical fingerprinting 15976 Shrinking majority of the deep biosphere suggest alternative explanation for deep sea Bo Barker Jørgensen coral observations See companion article on page 16213 Paul D. Boehm and Peter D. Carragher E2648 Reply to Boehm and Carragher: Multiple lines of PNAS PLUS (AUTHOR SUMMARIES) evidence link deep-water coral damage to Deepwater Horizon oil spill PHYSICAL SCIENCES Helen K. White, Pen-Yuan Hsing, Walter Cho, Timothy M. Shank, Erik E. Cordes, Andrea M. Quattrini, Robert K. APPLIED PHYSICAL SCIENCES Nelson, Richard Camilli, Amanda W. J. Demopoulos, Christopher R. German, James M. Brooks, Harry H. Roberts, 15978 Physical manipulation of the Escherichia coli William Shedd, Christopher M. Reddy, and Charles R. Fisher chromosome reveals its soft nature James Pelletier, Ken Halvorsen, Bae-Yeun Ha, Raffaella Paparcone, Steven J. Sandler, Conrad L. Woldringh, Wesley P. Wong, and Suckjoon Jun Free online through the PNAS open access option. See full research article on page E2649 of www.pnas.org

PNAS u October 2, 2012 u vol. 109 u no. 40 u iii–ix Downloaded by guest on September 30, 2021 SOCIAL SCIENCES MEDICAL SCIENCES 15991 Hypoxia-inducible factor 1-dependent expression of PSYCHOLOGICAL AND COGNITIVE SCIENCES platelet-derived growth factor B promotes lymphatic 15980 Persistent cannabis users show neuropsychological metastasis of hypoxic breast cancer cells decline from childhood to midlife Luana Schito, Sergio Rey, Marco Tafani, Huafeng Zhang, Madeline H. Meier, Avshalom Caspi, Antony Ambler, Carmen Chak-Lui Wong, Andrea Russo, Matteo A. Russo, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, and Gregg L. Semenza Kay McDonald, Aimee Ward, Richie Poulton, See full research article on page E2707 of www.pnas.org and Terrie E. Moffitt See full research article on page E2657 of www.pnas.org See Commentary on page 15970 NEUROSCIENCE 15993 Cannabinoid receptor 1-expressing neurons in the nucleus accumbens BIOLOGICAL SCIENCES Bradley D. Winters, Juliane M. Krüger, Xiaojie Huang, Zachary R. Gallaher, Masago Ishikawa, Krzysztof Czaja, APPLIED BIOLOGICAL SCIENCES James M. Krueger, Yanhua H. Huang, Oliver M. Schlüter, 15981 Phenotype-based high-content chemical library and Yan Dong screening identifies statins as inhibitors of See full research article on page E2717 of www.pnas.org in vivo lymphangiogenesis Martin Michael Peter Schulz, Felix Reisen, Silvana Zgraggen, 15994 Frequency-invariant temporal ordering of interneuronal Stephanie Fischer, Don Yuen, Gyeong Jin Kang, Lu Chen, discharges during hippocampal oscillations in Gisbert Schneider, and Michael Detmar awake mice See full research article on page E2665 of www.pnas.org Csaba Varga, Peyman Golshani, and Ivan Soltesz See full research article on page E2726 of www.pnas.org

BIOPHYSICS AND COMPUTATIONAL BIOLOGY 15978 Physical manipulation of the Escherichia coli chromosome reveals its soft nature PERSPECTIVE James Pelletier, Ken Halvorsen, Bae-Yeun Ha, Raffaella Paparcone, Steven J. Sandler, Conrad L. Woldringh, 15996 Microbial oceanography of anoxic oxygen Wesley P. Wong, and Suckjoon Jun minimum zones See full research article on page E2649 of www.pnas.org Osvaldo Ulloa, Donald E. Canfield, Edward F. DeLong, 15983 Conformational state of the MscS mechanosensitive Ricardo M. Letelier, and Frank J. Stewart channel in solution revealed by pulsed electron–electron double resonance (PELDOR) spectroscopy Christos Pliotas, Richard Ward, Emma Branigan, Akiko Rasmussen, Gregor Hagelueken, Hexian Huang, INAUGURAL ARTICLE Susan S. Black, Ian R. Booth, Olav Schiemann, and James H. Naismith 16004 Nonsteroidal anti-inflammatory drug sensitizes See full research article on page E2675 of www.pnas.org Mycobacterium tuberculosis to endogenous and exogenous antimicrobials Ben Gold, Maneesh Pingle, Steven J. Brickner, Nilesh EVOLUTION Shah, Julia Roberts, Mark Rundell, W. Clay Bracken, 15985 Sex, prions, and plasmids in yeast Thulasi Warrier, Selin Somersan, Aditya Venugopal, Amy C. Kelly, Frank P. Shewmaker, Dmitry Kryndushkin, Crystal Darby, Xiuju Jiang, J. David Warren, Joseph and Reed B. Wickner Fernandez, Ouathek Ouerfelli, Eric L. Nuermberger, See full research article on page E2683 of www.pnas.org Amy Cunningham-Bussel, Poonam Rath, Tamutenda Chidawanyika, Haiteng Deng, Ronald Realubit, J. Fraser Glickman, and Carl F. Nathan GENETICS 15987 Small RNA binding site multiplicity involved in translational regulation of a polycistronic mRNA PHYSICAL SCIENCES Jennifer B. Rice, Divya Balasubramanian, and Carin K. Vanderpool See full research article on page E2691 of www.pnas.org APPLIED MATHEMATICS 16012 Resolving a paradox of anomalous scalings in the diffusion of granular materials IMMUNOLOGY Ivan C. Christov and Howard A. Stone 15989 Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses Rika Ouchida, Hiromi Mori, Koji Hase, Hiroyuki Takatsu, APPLIED PHYSICAL SCIENCES Tomohiro Kurosaki, Takeshi Tokuhisa, Hiroshi Ohno, 16018 High-throughput lensfree 3D tracking of human sperms and Ji-Yang Wang reveals rare statistics of helical trajectories See full research article on page E2699 of www.pnas.org Ting-Wei Su, Liang Xue, and Aydogan Ozcan

iv u www.pnas.org Downloaded by guest on September 30, 2021 16023 Multi-scale kinetics of a field-directed colloidal STATISTICS phase transition 16161 Statistical inference of the generation probability of James W. Swan, Paula A. Vasquez, Peggy A. Whitson, T-cell receptors from sequence repertoires E. Michael Fincke, Koichi Wakata, Sandra H. Magnus, Frank Anand Murugan, Thierry Mora, Aleksandra M. Walczak, De Winne, Michael R. Barratt, Juan H. Agui, Robert D. Green, and Curtis G. Callan, Jr. Nancy R. Hall, Donna Y. Bohman, Charles T. Bunnell, Alice P. Gast, and Eric M. Furst 16029 Role of isostaticity and load-bearing microstructure in the elasticity of yielded colloidal gels SOCIAL SCIENCES Lilian C. Hsiao, Richmond S. Newman, Sharon C. Glotzer, and Michael J. Solomon PSYCHOLOGICAL AND COGNITIVE SCIENCES 16318 Altered fear learning across development in both mouse CHEMISTRY and human 16035 Alternating electron and proton transfer steps in Siobhan S. Pattwell, Stéphanie Duhoux, Catherine A. photosynthetic water oxidation Hartley, David C. Johnson, Deqiang Jing, Mark D. Elliott, André Klauss, Michael Haumann, and Holger Dau Erika J. Ruberry, Alisa Powers, Natasha Mehta, Rui R. Yang, Fatima Soliman, Charles E. Glatt, B. J. Casey, Ipe Ninan, 16041 Gene expression changes in a tumor xenograft by and Francis S. Lee a pyrrole-imidazole polyamide Jevgenij A. Raskatov, Nicholas G. Nickols, Amanda E. 16389 New Caledonian crows reason about hidden Hargrove, Georgi K. Marinov, Barbara Wold, causal agents and Peter B. Dervan Alex H. Taylor, Rachael Miller, and Russell D. Gray 16046 Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated SUSTAINABILITY SCIENCE quinoid carcinogens and H2O2 16083 Global forecasts of urban expansion to 2030 and direct Ben-Zhan Zhu, Li Mao, Chun-Hua Huang, Hao Qin, Rui-Mei impacts on biodiversity and carbon pools Fan, Balaraman Kalyanaraman, and Jun-Ge Zhu Karen C. Seto, Burak Güneralp, and Lucy R. Hutyra 16155 Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy Hagen Hofmann, Andrea Soranno, Alessandro Borgia, BIOLOGICAL SCIENCES Klaus Gast, Daniel Nettels, and Benjamin Schuler ANTHROPOLOGY EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 16089 Late Pleistocene climate change and the global expansion of anatomically modern humans 16052 Dynamics of the last glacial maximum Antarctic ice-sheet Anders Eriksson, Lia Betti, Andrew D. Friend, Stephen J. and its response to ocean forcing Lycett, Joy S. Singarayer, Noreen von Cramon-Taubadel, Nicholas R. Golledge, Christopher J. Fogwill, Andrew N. Paul J. Valdes, Francois Balloux, and Andrea Manica Mackintosh, and Kevin M. Buckley

ENGINEERING APPLIED BIOLOGICAL SCIENCES 16057 Spontaneous shape reconfigurations in 16095 Engineering neonatal Fc receptor-mediated recycling multicompartmental microcylinders and transcytosis in recombinant proteins by short Kyung Jin Lee, Jaewon Yoon, Sahar Rahmani, Sangyeul terminal peptide extensions Hwang, Srijanani Bhaskar, Samir Mitragotri, Jonathan T. Sockolosky, Matthew R. Tiffany, and Joerg Lahann and Francis C. Szoka

MATHEMATICS BIOCHEMISTRY fi 16063 Unimodal sequences and quantum and mock 16101 Synthesis of site-speci c antibody-drug conjugates using modular forms unnatural amino acids Jennifer Bryson, Ken Ono, Sarah Pitman, Jun Y. Axup, Krishna M. Bajjuri, Melissa Ritland, and Robert C. Rhoades Benjamin M. Hutchins, Chan Hyuk Kim, Stephanie A. Kazane, Rajkumar Halder, Jane S. Forsyth, Antonio F. Santidrian, Karin Stafin, Yingchun Lu, Hon Tran, Aaron J. PHYSICS Seller, Sandra L. Biroc, Aga Szydlik, Jason K. Pinkstaff, Feng 16068 On the strength of glasses Tian, Subhash C. Sinha, Brunhilde Felding-Habermann, Apiwat Wisitsorasak and Peter G. Wolynes Vaughn V. Smider, and Peter G. Schultz 16073 Frost halos from supercooled water droplets 16107 Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate Stefan Jung, Manish K. Tiwari, and Dimos Poulikakos Byung Hak Ha, Matthew J. Davis, Catherine Chen, Hua Jane 16079 Unforgeable noise-tolerant quantum tokens Lou, Jia Gao, Rong Zhang, Michael Krauthammer, Ruth Fernando Pastawski, Norman Y. Yao, Liang Jiang, Halaban, Joseph Schlessinger, Benjamin E. Turk, Mikhail D. Lukin, and J. Ignacio Cirac and Titus J. Boggon

vi u www.pnas.org Downloaded by guest on September 30, 2021 16113 The Ndc80 kinetochore complex directly modulates 16179 Engineering a model protein cavity to catalyze the microtubule dynamics Kemp elimination Neil T. Umbreit, Daniel R. Gestaut, Jerry F. Tien, Breanna S. Matthew Merski and Brian K. Shoichet Vollmar, Tamir Gonen, Charles L. Asbury, and Trisha N. Davis CELL BIOLOGY See Commentary on page 15972 16184 Insulin stimulation of SREBP-1c processing in transgenic 16119 α-Synuclein disrupts stress signaling by inhibiting rat hepatocytes requires p70 S6-kinase polo-like kinase Cdc5/Plk2 Joshua L. Owen, Yuanyuan Zhang, Soo-Han Bae, Midhat S. Shaoxiao Wang, Baoshan Xu, Liang-Chun Liou, Qun Ren, Farooqi, Guosheng Liang, Robert E. Hammer, Joseph L. Shile Huang, Yan Luo, Zhaojie Zhang, and Stephan N. Witt Goldstein, and Michael S. Brown See Commentary on page 15974 16125 A kinetic clutch governs religation by type IB – topoisomerases and determines 16190 Detection of a rare BCR ABL tyrosine kinase fusion camptothecin sensitivity protein in H929 multiple myeloma cells using Yeonee Seol, Hongliang Zhang, Yves Pommier, immunoprecipitation (IP)-tandem mass and Keir C. Neuman spectrometry (MS/MS) Susanne B. Breitkopf, Min Yuan, German A. Pihan, 16131 Structural basis for the sheddase function of human and John M. Asara meprin β metalloproteinase at the plasma membrane 16196 Identification of a specific reprogramming-associated Joan L. Arolas, Claudia Broder, Tamara Jefferson, Tibisay epigenetic signature in human induced pluripotent Guevara, Erwin E. Sterchi, Wolfram Bode, Walter Stöcker, stem cells Christoph Becker-Pauly, and F. Xavier Gomis-Rüth Sergio Ruiz, Dinh Diep, Athurva Gore, Athanasia D. 16137 Aberrantly elevated microRNA-34a in obesity attenuates Panopoulos, Nuria Montserrat, Nongluk Plongthongkum, hepatic responses to FGF19 by targeting a membrane Sachin Kumar, Ho-Lim Fung, Alessandra Giorgetti, Josipa coreceptor β-Klotho Bilic, Erika M. Batchelder, Holm Zaehres, Natalia G. Kan, Ting Fu, Sung-E Choi, Dong-Hyun Kim, Sunmi Seok, Hans Robert Schöler, Mark Mercola, Kun Zhang, Kelly M. Suino-Powell, H. Eric Xu, and Juan Carlos Izpisua Belmonte and Jongsook Kim Kemper

16143 Platelet biogenesis and functions require correct DEVELOPMENTAL BIOLOGY protein O-glycosylation 16202 Zfp281 mediates Nanog autorepression through Yingchun Wang, Shawn M. Jobe, Xiaokun Ding, Hyojung recruitment of the NuRD complex and inhibits Choo, David R. Archer, Rongjuan Mi, Tongzhong Ju, somatic cell reprogramming and Richard D. Cummings Miguel Fidalgo, Francesco Faiola, Carlos-Filipe Pereira, Junjun Ding, Arven Saunders, Julian Gingold, Christoph 16149 Mitochondrial ribonuclease P structure provides insight Schaniel, Ihor R. Lemischka, José C. R. Silva, into the evolution of catalytic strategies for and Jianlong Wang precursor-tRNA 5′ processing Michael J. Howard, Wan Hsin Lim, Carol A. Fierke, and Markos Koutmos ECOLOGY 16208 The widely used small subunit 18S rDNA molecule greatly underestimates true diversity in biodiversity BIOPHYSICS AND COMPUTATIONAL BIOLOGY surveys of the meiofauna Cuong Q. Tang, Francesca Leasi, Ulrike Obertegger, 16035 Alternating electron and proton transfer steps in Alexander Kieneke, Timothy G. Barraclough, photosynthetic water oxidation and Diego Fontaneto André Klauss, Michael Haumann, and Holger Dau

16155 Polymer scaling laws of unfolded and intrinsically ENVIRONMENTAL SCIENCES disordered proteins quantified with single-molecule spectroscopy 16213 Global distribution of microbial abundance and biomass fl Hagen Hofmann, Andrea Soranno, Alessandro Borgia, in subsea oor sediment Klaus Gast, Daniel Nettels, and Benjamin Schuler Jens Kallmeyer, Robert Pockalny, Rishi Ram Adhikari, David C. Smith, and Steven D’Hondt 16161 Statistical inference of the generation probability of See Commentary on page 15976 T-cell receptors from sequence repertoires Anand Murugan, Thierry Mora, Aleksandra M. Walczak, EVOLUTION and Curtis G. Callan, Jr. 16217 Hemisphere-scale differences in conifer 16167 Programmed −1 frameshifting efficiency correlates evolutionary dynamics with RNA pseudoknot conformational plasticity, Andrew B. Leslie, Jeremy M. Beaulieu, Hardeep S. Rai, not resistance to mechanical unfolding Peter R. Crane, Michael J. Donoghue, and Sarah Mathews Dustin B. Ritchie, Daniel A. N. Foster, fl and Michael T. Woodside 16222 Closely related bird species demonstrate exibility between beak morphology and underlying 16173 Complexity of chromatin folding is captured by the developmental programs strings and binders switch model Ricardo Mallarino, Otger Campàs, Joerg A. Fritz, Kevin J. Mariano Barbieri, Mita Chotalia, James Fraser, Liron-Mark Burns, Olivia G. Weeks, Michael P. Brenner, Lavitas, Josée Dostie, Ana Pombo, and Mario Nicodemi and Arhat Abzhanov

PNAS u October 2, 2012 u vol. 109 u no. 40 u vii Downloaded by guest on September 30, 2021 16228 Upper thermal limits of Drosophila are linked to species MEDICAL SCIENCES distributions and strongly constrained phylogenetically 16004 Nonsteroidal anti-inflammatory drug sensitizes Vanessa Kellermann, Johannes Overgaard, Ary A. Hoffmann, Mycobacterium tuberculosis to endogenous Camilla Fløjgaard, Jens-Christian Svenning, and exogenous antimicrobials and Volker Loeschcke Ben Gold, Maneesh Pingle, Steven J. Brickner, Nilesh Shah, Julia Roberts, Mark Rundell, W. Clay Bracken, GENETICS Thulasi Warrier, Selin Somersan, Aditya Venugopal, 16234 Transcriptional profiling in facioscapulohumeral Crystal Darby, Xiuju Jiang, J. David Warren, Joseph Fernandez, Ouathek Ouerfelli, Eric L. Nuermberger, muscular dystrophy to identify candidate biomarkers Amy Cunningham-Bussel, Poonam Rath, Tamutenda Fedik Rahimov, Oliver D. King, Doris G. Leung, Genila M. Chidawanyika, Haiteng Deng, Ronald Realubit, Bibat, Charles P. Emerson, Jr., Louis M. Kunkel, J. Fraser Glickman, and Carl F. Nathan and Kathryn R. Wagner 16041 Gene expression changes in a tumor xenograft by 16240 Features of the Arabidopsis recombination landscape a pyrrole-imidazole polyamide resulting from the combined loss of sequence Jevgenij A. Raskatov, Nicholas G. Nickols, Amanda E. variation and DNA methylation Hargrove, Georgi K. Marinov, Barbara Wold, Maria Colomé-Tatché, Sandra Cortijo, René Wardenaar, and Peter B. Dervan Lionel Morgado, Benoit Lahouze, Alexis Sarazin, Mathilde Etcheverry, Antoine Martin, Suhua Feng, Evelyne 16282 Transient receptor potential channel TRPC5 is essential Duvernois-Berthet, Karine Labadie, Patrick Wincker, for P-glycoprotein induction in drug-resistant Steven E. Jacobsen, Ritsert C. Jansen, Vincent Colot, cancer cells and Frank Johannes Xin Ma, Yanfei Cai, Dongxu He, Chang Zou, Peng Zhang, Chun Yin Lo, Zhenyu Xu, Franky L. Chan, Shan Yu, Yun 16246 Functional transcriptomics of a migrating cell in Chen, Ruiyu Zhu, Jianyong Lei, Jian Jin, and Xiaoqiang Yao Caenorhabditis elegans Erich M. Schwarz, Mihoko Kato, and Paul W. Sternberg 16288 Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics IMMUNOLOGY Sean Marrache and Shanta Dhar 16252 Heterogeneous nuclear ribonucleoprotein L-like 16294 Diet-induced metabolic change induces (hnRNPLL) and elongation factor, RNA polymerase II, 2 estrogen-independent allometric mammary growth (ELL2) are regulators of mRNA processing in plasma cells Grace E. Berryhill, Julia M. Gloviczki, Josephine F. Trott, Micah J. Benson, Tarmo Äijö, Xing Chang, John Gagnon, Lucila Aimo, Jana Kraft, Robert D. Cardiff, Carly T. Paul, Utz J. Pape, Vivek Anantharaman, L. Aravind, Juha-Pekka Whitney K. Petrie, Adam L. Lock, and Russell C. Hovey Pursiheimo, Shalini Oberdoerffer, X. Shirley Liu, Riitta Lahesmaa, Harri Lähdesmäki, and Anjana Rao MICROBIOLOGY 16258 Dependence on nuclear factor of activated T-cells (NFAT) 16300 Staphylococcal pathogenicity island interference with levels discriminates conventional T cells from Foxp3+ helper phage reproduction is a paradigm of regulatory T cells molecular parasitism Martin Vaeth, Ulrike Schliesser, Gerd Müller, Sonja Reissig, Geeta Ram, John Chen, Krishan Kumar, Hope F. Ross, Kazuki Satoh, Andrea Tuettenberg, Helmut Jonuleit, Ari Carles Ubeda, Priyadarshan K. Damle, Kristin D. Lane, Waisman, Martin R. Müller, Edgar Serfling, Birgit S. José R. Penadés, Gail E. Christie, and Richard P. Novick Sawitzki, and Friederike Berberich-Siebelt 16306 Regulation of bacterial photosynthesis genes by the 16264 Development of promyelocytic leukemia zinc small noncoding RNA PcrZ finger-expressing innate CD4 T cells requires stronger Nils N. Mank, Bork A. Berghoff, Yannick N. Hermanns, T-cell receptor signals than conventional CD4 T cells and Gabriele Klug Yu Qiao, Lingqiao Zhu, Hanief Sofi, Philip E. Lapinski, Reiko 16312 CD73-generated adenosine facilitates Toxoplasma Horai, Kristen Mueller, Gretta L. Stritesky, Xi He, Hung-Sia gondii differentiation to long-lived tissue cysts Teh, David L. Wiest, Dietmar J. Kappes, Philip D. King, in the central nervous system Kristin A. Hogquist, Pamela L. Schwartzberg, Derek B. Deeqa A. Mahamed, Jeffrey H. Mills, Charlotte E. Egan, Sant’Angelo, and Cheong-Hee Chang Eric Y. Denkers, and Margaret S. Bynoe 16270 DEC-205 is a cell surface receptor for CpG oligonucleotides NEUROSCIENCE Mireille H. Lahoud, Fatma Ahmet, Jian-Guo Zhang, Simone 16318 Altered fear learning across development in both mouse Meuter, Antonia N. Policheni, Susie Kitsoulis, Chin-Nien Lee, and human Meredith O’Keeffe, Lucy C. Sullivan, Andrew G. Brooks, Siobhan S. Pattwell, Stéphanie Duhoux, Catherine A. Richard Berry, Jamie Rossjohn, Justine D. Mintern, Javier Hartley, David C. Johnson, Deqiang Jing, Mark D. Elliott, Vega-Ramos, Jose A. Villadangos, Nicos A. Nicola, Erika J. Ruberry, Alisa Powers, Natasha Mehta, Rui R. Yang, Michel C. Nussenzweig, Katryn J. Stacey, Ken Shortman, Fatima Soliman, Charles E. Glatt, B. J. Casey, Ipe Ninan, William R. Heath, and Irina Caminschi and Francis S. Lee 16276 Dual signaling by innate and adaptive immune 16324 siRNA silencing of estrogen receptor-α expression receptors is required for TLR7-induced specifically in medial preoptic area neurons B-cell–mediated autoimmunity abolishes maternal care in female mice Elizabeth R. Walsh, Prapaporn Pisitkun, Elisaveta Voynova, Ana C. Ribeiro, Sergei Musatov, Anna Shteyler, Serge Jonathan A. Deane, Bethany L. Scott, Rachel R. Caspi, Simanduyev, Isabel Arrieta-Cruz, Sonoko Ogawa, and Silvia Bolland and Donald W. Pfaff

viii u www.pnas.org Downloaded by guest on September 30, 2021 16330 Cell-type specific deletion of GABA(A)α1 in 16377 Identification of a BAHD acetyltransferase that produces corticotropin-releasing factor-containing neurons protective acyl sugars in tomato trichomes enhances anxiety and disrupts fear extinction Anthony L. Schilmiller, Amanda L. Charbonneau, Georgette M. Gafford, Ji-Dong Guo, Elizabeth I. Flandreau, and Robert L. Last Rimi Hazra, Donald G. Rainnie, and Kerry J. Ressler 16383 Completion of the core β-oxidative pathway of benzoic 16336 Interplay between electrical activity and bone acid biosynthesis in plants morphogenetic protein signaling regulates Anthony V. Qualley, Joshua R. Widhalm, Funmilayo spinal neuron differentiation Adebesin, Christine M. Kish, and Natalia Dudareva Immani Swapna and Laura N. Borodinsky PSYCHOLOGICAL AND COGNITIVE SCIENCES PHARMACOLOGY 16389 New Caledonian crows reason about hidden 16342 Distinct roles of metabotropic glutamate receptor causal agents dimerization in agonist activation and Alex H. Taylor, Rachael Miller, and Russell D. Gray G-protein coupling Driss El Moustaine, Sébastien Granier, Etienne Doumazane, Pauline Scholler, Rita Rahmeh, Patrick Bron, Bernard Mouillac, Jean-Louis Banères, Philippe Rondard, CORRECTIONS and Jean-Philippe Pin 16348 Discovery of an orally active small-molecule irreversible BIOPHYSICS AND COMPUTATIONAL BIOLOGY inhibitor of protein disulfide isomerase for ovarian 16392 Folding helical proteins in explicit solvent using cancer treatment dihedral-biased tempering Shili Xu, Alexey N. Butkevich, Roppei Yamada, Yu Zhou, Cheng Zhang and Jianpeng Ma Bikash Debnath, Roger Duncan, Ebrahim Zandi, Nicos A. Petasis, and Nouri Neamati CELL BIOLOGY 16393 Aberrant E2F activation by polyglutamine expansion of PHYSIOLOGY androgen receptor in SBMA neurotoxicity 16354 Calcium-activated chloride channel TMEM16A Eriko Suzuki, Yue Zhao, Saya Ito, Shun Sawatsubashi, Takuya modulates mucin secretion and airway smooth Murata, Takashi Furutani, Yuko Shirode, Kaoru Yamagata, muscle contraction Masahiko Tanabe, Shuhei Kimura, Takashi Ueda, Sally Fen Huang, Hongkang Zhang, Meng Wu, Huanghe Yang, Fujiyama, Jinseon Lim, Hiroyuki Matsukawa, Alexander P. Makoto Kudo, Christian J. Peters, Prescott G. Woodruff, Kouzmenko, Toshiro Aigaki, Tetsuya Tabata, Ken-ichi Owen D. Solberg, Matthew L. Donne, Xiaozhu Huang, Dean Takeyama, and Shigeaki Kato Sheppard, John V. Fahy, Paul J. Wolters, Brigid L. M. Hogan, Walter E. Finkbeiner, Min Li, Yuh-Nung Jan, Lily Yeh Jan, and Jason R. Rock IMMUNOLOGY 16393 Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating PLANT BIOLOGY effector T-cell function 16360 Integration of stress-related and reactive oxygen Li-Fen Lee, Kathryn Logronio, Guang Huan Tu, Wenwu species-mediated signals by Topoisomerase VI Zhai, Irene Ni, Li Mei, Jeanette Dilley, Jessica Yu, Arvind in Arabidopsis thaliana Rajpal, Colleen Brown, Charles Appah, Sherman Michael  Klára Simková, Fanny Moreau, Piotr Pawlak, Cécile Vriet, Chin, Bora Han, Timothy Affolter, and John C. Lin Aiswarya Baruah, Cristina Alexandre, Lars Hennig, Klaus Apel, and Christophe Laloi MEDICAL SCIENCES 16366 C-terminal region of the UV-B photoreceptor UVR8 – initiates signaling through interaction with the 16393 Triclosan impairs excitation contraction coupling and 2+ COP1 protein Ca dynamics in striated muscle Catherine Cloix, Eirini Kaiserli, Monika Heilmann, Gennady Cherednichenko, Rui Zhang, Roger A. Bannister, Katherine J. Baxter, Bobby A. Brown, Andrew O’Hara, Valeriy Timofeyev, Ning Li, Erika B. Fritsch, Wei Feng, Brian O. Smith, John M. Christie, and Gareth I. Jenkins Genaro C. Barrientos, Nils H. Schebb, Bruce D. Hammock, Kurt G. Beam, Nipavan Chiamvimonvat, and Isaac N. Pessah 16371 Distinct regions of the Pseudomonas syringae coiled-coil effector AvrRps4 are required for activation of immunity xi Subscription Form Kee Hoon Sohn, Richard K. Hughes, Sophie J. Piquerez, Jonathan D. G. Jones, and Mark J. Banfield xii Classified Advertisements

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