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Pathology of the Eye Dedicated to Hans Sautter and Lorenz E Pathology of the Eye Dedicated to Hans Sautter and Lorenz E. Zimmerman G.O.H.Naumann D.J.Apple Pathology of the Eye With Contributions by D. von Domarus E.N.Hinzpeter R.M. Manthey L.R. Naumann K.W. Ruprecht H.E. Volcker Translated by D.J. Apple With 544 Illustrations in 1002 Parts Springer-Verlag New York Berlin Heidelberg Tokyo G.O.H. NAUMANN, M.D. Chairman, Department of Ophthalmology, University of Erlangen­ Nlirnberg, 8520 Erlangen, Federal Republic of Germany DJ. ApPLE, M.D. Professor of Ophthalmology and Pathology, University of Utah School of Medicine, University Health Sciences Center, Salt Lake City, Utah, 84132, U.S.A. Library of Congress Cataloging in Publication Data Naumann, G.O.H. Pathology of the eye. "Translated and updated from the German edition: Pathologie des Auges"-T.p. verso. Includes bibliographies and index. 1. Eye-Diseases. I. Apple, David J., 1941- II. Title. [DNLM: 1. Eye-pathology. 2. Eye Diseases­ pathology. WW 140 N311p] RE46.N3813 1985 617.17'1 85-14796 Translated and updated from the German edition: Pathologie des Auges. © by Springer-Verlag Berlin Heidelberg New York 1980. © 1986 by Springer-Verlag New York, Inc. Softcover reprint of the hardcover 1st edition 1986 All rights reserved. No part of this book may be translated or reproduced in any form without written permission from Springer-Verlag, 175 Fifth Avenue, New York, New York 10010, U.S.A. The use of general descriptive names, trade names, trademarks, etc., in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. While the advice and information of this book is believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to material contained herein. Typeset by Kingsport Press, Tennessee. 9 8 765 4 3 2 I ISBN-13: 978-1-4613-8527-1 e-ISBN-13: 978-1-4613-8525-7 001-10.1007/978-1-4613-8525-7 Foreword It is indeed a pleasure to write a foreword for this spectacular book which represents a landmark in the history of ocular pathology. Not since the three volumes of the Henke-Lubarsch handbook appeared forty years ago has anything like this come on the market. This book represents a compre­ hensive, thorough and up-to-date clinically oriented textbook on ocular pathology. We are all indebted to the senior author, who is now professor of ophthal­ mology at the University of Erlangen, who presents us here with the fruit of decades of industrious endeavors. We also have to be grateful to the American ophthalmic pathologist, Dr. David Apple, who, as one of the main collaborators of the German edition, has now provided us with the English translation. The book has a twofold purpose: First, it is meant to be a source of instruction for ophthalmologists and pathologists. For that purpose it is beautifully illustrated both by clinical pictures and by excellent photomicro­ graphs and electromicroscopic pictures. Most valuable from a didactic point of view are the colored schematic drawings and the many tables. These two features are practically unique and should help any neophyte in grasp­ ing the principles of ocular pathology. The second objective of this book is as a reference book for any type of investigation concerned with ocular pathology. The list of references (exceeding 5,000 citations) is indeed staggering and reflects the thorough­ ness and scholarship of the authors. The references cover not only publica­ tions in German and English, but also many works published in other languages. This gives the book a true cosmopolitan character. This book will become the yardstick against which any other future publi­ cations in ocular pathology will have to be measured. FREDERICK C. BLODI, M.D. Iowa City, Iowa Preface We are pleased to introduce an English translation of this textbook of ocular pathology, which appeared with the title Pathologie des Auges in the original German edition in 1980. The original edition was the first compre­ hensive textbook of ocular pathology that had appeared in the German language since the classic three volume work of Henke and Lubarsch, which was published between 1928 and 1937. In this English edition we have updated many sections and added numer­ ous references that are current throughout 1985. Aside from the two-col­ ored schematic line drawings and the differential diagnosis tables, one unique feature of this book is that it contains up-to-date English references from the literature, and references to much of the European literature of this century. This will be very useful for the scholar who wishes to research the background of many diseases. In addition to our colleagues and staff at the Universities of Hamburg, Tiibingen, Erlangen-Niirnberg, Illinois, and Utah, we would like to thank the Alexander von Humboldt Foundation, Bonn-Bad Godesberg, West Ger­ many for support in the preparation of this translation and update. This work was done in part under the auspices of Professor Erich Weigelin of the University of Bonn, West Germany. We would also like to thank Dr. Randall J. Olson, Professor and Chairman of the Department of Ophthal­ mology, University of Utah Health Science Center, for providing the finan­ cial support and facilities that made this translation possible. G.O.H. NAUMANN DAVID J. ApPLE Acknowledgments We express our gratitude to Prof. H.C. Sautter, Director of the University Eye Hospital of Hamburg from 1953 through 1981. He allowed access to the files of clinical photographs and histopathological material, which represent a portion of the figures in this book. We also had the opportunity to utilize the collection of Prof. Wolfgang Stock, Director of the University Eye Hospital of Ttibingen from 1912 through 1953. The beautiful sections are still impressive and instructive today. We also express our gratitude to the staff of the University of Illinois Eye and Ear Infirmary and the Theobald Laboratory of Ocular Pathology for contributions of figures to this book. The source of figures is cited only if they have been previously published. The invaluable assistance of Miss Portwich and Mrs. Seibel in the prepa­ ration of histological sections, and Miss Hadlok and Mr. Schneider in taking clinical photographs and providing photographs from the histological sec­ tions, must be reemphasized for this edition. The graphic drawings were prepared by Mrs. Gay, Stuttgart, under the supervision of the senior author. At the University of Utah Health Sciences Center, Diane Rikkers and Lou H. Allred provided essential secretarial assistance, while Laura Lee Smith, Dolores K. Van Norman, and Steven M. Thiese furnished invaluable edito­ rial assistance. The significant contributions of the following people to this work is ac­ knowledged: D. VON DOMARUS, M.D., Professor, Department of Ophthalmology, Univer­ sity of Hamburg, 2000 Hamburg 20, Federal Republic of Germany E.N. HINZPETER, M.D., Chief, Eye-Hospital, Allgemeines Krankenhaus Heid­ berg, 2000 Hamburg 20, Federal Republic of Germany R.M. MANTHEY, M.D., Jules Stein Eye Institute (UCLA), Kelman Fellow, Cornea and External Disease Division, UCLA Medical Center, Los Ange­ les, California, USA L.R. NAUMANN, M.D., Department of Ophthalmology, University Erlangen­ Ntirnberg, 8520 Erlangen, Federal Republic of Germany K.W. RUPRECHT, M.D., Professor, Department of Ophthalmology, University Erlangen-Ntirnberg, 8520 Erlangen, Federal Republic of Germany H.E. VOLCKER, M.D., Professor, Department of Ophthalmology, University Erlangen-Ntirnberg, 8520 Erlangen, Federal Republic of Germany General References in Ophthalmic Pathology Apple Dj, Rabb MF: Ocular Pathology-Clinical Applications and Self­ Assessment, ed. 3. (Formerly Clinicopathologico Correlation of Ocular Disease: A Text and Stereoscopic Atlas), Mosby, St. Louis, 1985 Garner A, Klintworth GK (eds.): Pathobiology of Ocular Disease: A Dy­ namic Process (2 Vols), Marcel Dekker, Inc., New York, 1982 Hogan Mj, Zimmerman LE: Ophthalmic Pathology-An Atlas and Text­ book, 2nd edition. W. B. Saunders Co, London-Philadelphia, 1962 Spencer WH (ed.), Font RL, Green WR, Howes ELjr,jakobiec FA, Zimmer­ man LE: Ophthalmic Pathology-An Atlas and Textbook (3 Vols), 3rd edition. W.B. Saunders Co, Philadelphia, 1985 T.N.M.-Classification of Ophthalmic Tumors International Union Against Cancer, Geneva 1985 YanoffM, Fine BS: Ocular Pathology. A Text and Atlas, 2nd edition, Harper & Row, New York, 1982 World Health Organization: International Histological Classification of Tumours, Geneva, 1969-1980 Zimmerman LE, Sobin L: International Histological Classification of Tu­ mors, Nr. 24: Histological Typing of Tumours of the Eye and its Adnexa WHO, Geneva, 1980 Contents Selected Table of Contents xv General Anatomy and Development of the Eye: Techniques of Investigation DJ. ApPLE, G.O.H. NAUMANN 2 Microscopic Anatomy of the Eye DJ. ApPLE, G.O.H. NAUMANN, and R.M. MANTHEY 19 3 Malformations and Anomalies of the Eye DJ. ApPLE and G.O.H. NAUMANN 63 4 Intraocular Inflammations G.O.H. NAUMANN and L.R. NAUMANN. 99 5 Accidental and Surgical Trauma and Wound Healing of the Eye D. VON DOMARUS and G.O.H. NAUMANN. 185 6 Conjunctiva H.E. VOLCKER and G.O.H. NAUMANN. 249 7 Cornea and Sclera E.N. HINZPETER and G.O.H. NAUMANN 317 8 Uvea G.O.H. NAUMANN. 413 9 Lens G.O.H. NAUMANN. 509 10 Vitreous H.E. VOLCKER and G.O.H. NAUMANN. 557 11 Retina DJ. ApPLE and G.O.H. NAUMANN 577 XIV Contents 12 General Pathology of the Retina: Correlation of the Ophthalmoscopic Appearance with Tissue Morphology G.O.H.
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