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Combined Detachments in Wegener's Granulomatosis

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Combined Detachments in Wegener's Granulomatosis Br J Ophthalmol: first published as 10.1136/bjo.65.8.564 on 1 August 1981. Downloaded from British Journal of Ophthalmology, 1981, 65, 564-567 Combined detachments in Wegener's granulomatosis ALBERT S. LEVEILLE AND PETER H. MORSE From the Department of Ophthalmology, the Eye Research Laboratories, University of Chicago Hospitals and Clinics, Chicago, Illinois, USA SUMMARY We report a case with limited Wegener's granulomatosis in which the eye findings were the initial and only evidence of the disease when the patient was first seen. The patient was unusual in that he developed bilateral combined choroidal and retinal detachments and severe necrotising scleritis, which led to bilateral globe perforations and loss of all sight. We recommend a trial of cytotoxic agents in progressive ocular inflammatory diseases unresponsive to other medications before there is irreversible loss of vision. Wegener's granulomatosis usually causes sinusitis, 6/30, Jaeger 10, and LE 6/12, Jaeger 3. Intraocular necrotising lung granulomas, glomerulonephritis, pressures were 15 mmHg in each eye. Episcleritis and and a widespread vasculitis that may affect any iridocyclitis with keratic precipitates and moderate. organ.' A limited form of the disease sparing the aqueous flare and cells were present bilaterally. sinuses and kidneys has a better prognosis, though Topical corticosteroids reduced the inflammation in 20% of patients still die despite treatment with 2 weeks. The episcleritis and iridocyclitis recurred 6 cyclophosphamide.24 weeks later as the topical corticosteroids were Proptosis caused by orbital pseudotumour, con- tapered. Topical, subtenon, and systemic corti- junctivitis, scleritis, keratitis, and optic nerve costeroids afforded little improvement. vasculitis are the most common ophthalmic manifes- The patient developed bilateral necrotising scleritis tations, although anterior and posterior uveitis, in December 1976 and was admitted to the hospital http://bjo.bmj.com/ retinal artery occlusion, and nasal lacrimal duct and extensively evaluated for systemic disease. The obstruction may also occur."8 Combined detachment evaluation included chest and hand roentgenograms, of the choroid and retina has been described histo- serological testing for syphilis, and tests for anti- logically,9 but, unlike other types of polyarteritis, this nuclear antibody titre and lupus erythematosus, all has not been seen prior to enucleation. 40% of cases of which were negative; and sheep cell agglutination in both forms have ophthalmic manifestations, and latex fixation tests, which were positive in low though these are seldom initial findings and, to our titres. Rheumatology consultants found no evidence on October 1, 2021 by guest. Protected copyright. knowledge, have not occurred without other organ of rheumatoid arthritis or other collagen vascular involvement.58 We report a case of limited diseases. Wegener's granulomatosis in which the ophthalmic Ocular treatment consisted of topical acetylcys- findings were initially the only evidence of the teine, prednisolone, atropine, methylcellulose, and disease. The ocular signs included exudative com- bland ointment (Lacrilube). Systemic penicillamine bined detachments and unusually severe sclerouveitis and prednisone were also given. During the following that led to bilateral globe perforations and blindness. month, the inflammatory reaction subsided. In February 1977 the patient developed bilateral Case report combined choroidal and serous retinal detachments. This condition, together with the severe anterior and A 61-year-old man was first seen in the eye clinic at posterior uveitis, reduced his visual acuity to RE the University of Chicago Hospitals and Clinics in 1/120 and LE 1/60 despite the continuation of September 1976 complaining of burning and redness systemic penicillamine and prednisone. The necro- of both eyes for 1 year. Best corrected vision was RE tising scleritis continued to worsen, and progressed to bilateral globe perforations in December 1977, at Correspondence to Peter H. Morse, MD, Eye Research Laboratories, which time he had no light perception in either eye. In 939 East 57th Street, Chicago, Illinois 60637, USA February 1978 the patient was admitted to another 564 Br J Ophthalmol: first published as 10.1136/bjo.65.8.564 on 1 August 1981. Downloaded from Combined detachments in Wegener's granulomatosis 565 Fig. I Lung biopsy specimen, showing granulomatous inflammation including giant cells, Iymphocytes, plasma cells, epithelioid cells, andfibroblastic proliferation effacing normal lung architecture. hospital with a draining rectal fistula, anorexia, and contained confluent areas of granulomatous inflam- bleeding haemorrhoids. The chest roentgenogram mation which included multinucleated giant cells, showed cavitating nodular lung lesions. A biopsy of lymphocytes, plasma cells, epithelioid cells, and the lingular lung lobe showed necrotising granuloma- fibroblastic proliferation effacing the normal pul- tous inflammation consistent with the diagnosis of monary architecture (Figs. 1 and 2). Extensive Wegener's granulomatosis. Review of the histo- vasculitis involved arterioles, medium sized arteries, pathology at the University of Chicago Hospitals and and some veins, indicated by an inflammatory infil- Clinics confirmed the diagnosis. The lung tissue trate in the vessel walls that consisted predominantly http://bjo.bmj.com/ on October 1, 2021 by guest. Protected copyright. Fig. 2 Lung biopsy specimen, showing arteriole with lvmphocvtes and plasma cells in the vessel wall, suggesting angiocentric inflammation. Br J Ophthalmol: first published as 10.1136/bjo.65.8.564 on 1 August 1981. Downloaded from 566 Albert S. Leveille and Peter H. Morse Fig. 3 The patient has bilateral phthisis bulbi, no lightperception, and marked restriction of extraocular movements. of lymphocytes and plasma cells, though some ever, also had sinusitis and pulmonary cysts on chest neutrophils were also seen. There was marked roentgenography. Two years later the patient lymphocytic and plasma cell infiltration within and developed corneoscleral ulcers in the fellow eye and around the walls of the bronchioles, in the alveolar skin ulcers which healed after treatment with systemic septa, and within the air spaces. The pleural surface prednisone and cyclophosphamide. showed marked hyalinisation and fibrosis, and con- Coutu and associates4 reported a case of limited tained lymphocyte, histiocyte, and plasma cell Wegener's granulomatosis in which the ophthalmic infiltration. findings were present initially and were the most http://bjo.bmj.com/ Treatment with cyclophosphamide for several severe manifestations of the disease. The patient, months eliminated the remaining ocular inflammation. however, also had an abnormal chest roentgeno- On follow-up examination in June 1980, the patient gram, and a lung biopsy confirmed the diagnosis. This had no light perception in either eye and bilateral patient developed diffuse chorioretinitis and neo- phthisis bulbi (Fig. 3). There was no evidence of vascular glaucoma. Despite the institution of treat- ocular inflammation, and the patient felt in good ment with systemic prednisone and azathioprine, general health. which subsequently led to control of the ocular on October 1, 2021 by guest. Protected copyright. inflammation, the patient lost all vision in both eyes. Discussion Our patient had limited Wegener's granulomatosis with bilateral combined detachments and severe Ophthalmic manifestations of Wegener's granuloma- necrotising scleritis that subsequently led to bilateral tosis are due to vasculitis and include proptosis, con- globe perforations. Vision was lost in both eyes junctivitis, episcleritis, scleritis, and peripheral before there was evidence of systemic involvement, corneal ulceration and vascularisation that may be despite a thorough search. Although combined indistinguishable from that of Mooren's ulcer.5'8 detachments occur in patients with uveitis alone or in Less commonly patients develop anterior and pos- association with polyarteritis, rheumatoid arthritis terior uveitis, retinal artery occlusion, optic nerve and other systemic diseases,'0-'2 to our knowledge vasculitis, and nasolacrimal duct obstruction.`-8 they have not been found in Wegener's granuloma- Ophthalmic involvement is usually not severe and, to tosis prior to enucleation. Brubaker and associates9 our knowledge, has not been reported as the sole, found a shallow retinal detachment histopathologic- initial manifestation of Wegener's granulomatosis. ally in 1 patient with Wegener's granulomatosis and Brubaker and associates9 described a patient that uveitis, but this was not evident prior to enucleation. presented with unilateral necrotising granulomatous The pathogenesis of combined choroidal and retinal sclerouveitis and intractable pain. The patient, how- detachments in uveitis is a severe choroidal vasculitis Br J Ophthalmol: first published as 10.1136/bjo.65.8.564 on 1 August 1981. Downloaded from Combined detachments in Wegener's granulomatosis 567 with marked vascular leakage causing a serous References separation of the choroid and often a serous detach- I Fauci AS. Wolff SM. Wegener's granulomatosis: studies in ment of the overlying retina. The most likely eighteen patients and a review of the literature. Medicine 1973; explanation for the absence of combined detach- 52: 535-61. 2 Carrington CB. Liebow AA. Limited forms of angiitis and ments in Wegener's granulomatosis is that the granulomatosis
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