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Generated by SRI International Pathway Tools Version 25.0, Authors S Authors: Pallavi Subhraveti Anamika Kothari Quang Ong Ron Caspi An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Peter D Karp Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Ecol444447-HmpCyc: Escherichia coli O157:H7 str. EC4206 Cellular Overview Connections between pathways are omitted for legibility. Tim Holland indole- homoserine a macrolide a macrolide a purine D-fructosyl- a polyaminean acid a heme a heme a heme a heme a cation a cation a cation a cation a cation multidrug multidrug multidrug a purine a polysaccharide a quaternary sodium a lyso- 3-acetate lactone D-methionine an an + + ferric ferric antibiotic antibiotic cytosine α-L- N-acetyl-α-D- L-cystine a D- a hexose an iron a tripeptide a siderophore L-lysine ferrichrome a dicarboxylate a dicarboxylate phosphonate phosphonate Na Na a cation fructose fructose fructose fructose a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside a sulfonate toluene amine sulfate phospholipid oligopeptide oligopeptide enterobactin enterobactin arabinopyranose galactosamine glucoronoside phosphate chelate 2+ 2+ a xenobiotic Cu Cd a vitamin a polyamine phosphonate a monosaccharide predicted B predicted predicted predicted predicted ATP- predicted 12 ATP-driven predicted predicted predicted ATP-driven ATP-driven ATP-driven driven transporter ATP-driven transporter transporter transporter transporter A1792 RhtB A2898 transporter transporter A0697 A4974 PotA A3871 PhnD PhnE PhnC transporter OppA A3099 A3324 CcmB CcmC CcmD CcmA CusB A4715 FieF CusF CusC CusA complex of FERRIC- FepD A3629 FruB MacB MacA EefD EefC EefA Tsx NupC YegT A1482 A1479 NupG A4758 A5427 CopA CadA AraE A0943 UidB UhpT A3078 AraH A1243 A5272 transporter BtuD A0626 TppB A4823 complex of A4845 LplT complex complex complex of complex of complex of complex of an ENTEROBACTIN- complex of a quaternary of Fructose of Fructose CPD-3604 CPD0-2241 CPD-218 oligopeptide COMPLEX TOLUENE amine indole- homoserine a macrolide a macrolide 2+ 2+ a polysaccharide a xenobiotic sodium a lyso- an a heme a heme a heme a heme a cation a cation a cation a cation a cation ferric multidrug multidrug multidrug Cu Cd α-L- a D- a hexose an iron a vitamin a tripeptide a siderophore 3-acetate lactone D-fructosyl- a dicarboxylate a dicarboxylate a polyamine a polyamine phosphonate phosphonate phosphonate Na + Na + a cation fructose fructose antibiotic antibiotic a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside a monosaccharide a sulfonate sulfate phospholipid oligopeptide enterobactin arabinopyranose L-cystine glucoronoside phosphate chelate B a purinecytosine a purine α 12 L-lysine an acid N-acetyl- -D- an ferric fructose fructose a quaternary ferrichrome galactosamine toluene D-methionine oligopeptide enterobactin amine 1-phosphate Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Carbohydrate Degradation N-acetylmuramoyl-L- N-acetylmuramoyl-L- N-acetylmuramoyl-L- N-acetylmuramoyl-L- a (3R)-3- a [protein]- a [formate C GDP-α-D-mannose a 2,3,4-saturated an oxidized a ribosomal (S)-3- ammonium biotin biosynthesis I Amine and Polyamine Biosynthesis Fermentation superpathway of glucose and xylose degradation SAM a reduced flavodoxin alanyl-D-isoglutaminyl- alanyl-D-isoglutaminyl- alanyl-D-isoglutaminyl- alanyl-D-isoglutaminyl- hydroxydecanoyl- L-tyrosine 4-methyl-5(β-hydroxyethyl) siroheme tetrahydromonapterin flavin biosynthesis I (bacteria and plants) chlorophyllide a biosynthesis chlorophyllide a biosynthesis I superpathay of heme acyl carrier protein metabolism glutathionylspermidine L-ascorbate molybdenum cofactor Metabolic Regulator mixed acid fermentation L-rhamnose degradation II glucose and glucose-1-phosphate degradation L-sorbose degradation lactose acetyltransferase]-glycine fatty acyl CoA cytochrome c552 protein-L-alanine hydroxybutanoyl-CoA hydroxide cob(II)yrinate a,c- superpathway of ubiquinol- trehalose degradation N-(β-D-asparaginyl)-L- L-lysyl-(glycyl) - N-(β-D-asparaginyl) gdp-mannose acyl-CoA fatty oxidation N-(β-D-asparatyl)-L- [acp] phosphate nitrite biosynthesis biosynthesis IV Biosynthesis fructose degradation degradation II anaerobic 5 formate- ribosomal- beta- diamide biosynthesis I 8 biosynthesis (prokaryotic) thiazole salvage (yeast) biosynthesis III (aerobic, light independent) biosynthesis from glutamate biosynthesis biosynthesis I (prokaryotes) β-D-glucose- VI (periplasmic) mannosyl hydrolase: low molecular putrescine α-D-glucose L-sorbose ribonucleoside- lysyl-D-alanyl-D-alanine- D-alanyl-D-alanine- -L-lysyl-D-alanine- dehydrogenase dependent protein-alanine complex, lysyl-D-alanyl-D-alanine- hydroxyacyl- reductase malonyl-CoA (early cobalt insertion) β β phosphoenolpyruvate L-rhamnose weight protein- 4-methyl-5-( - 7,8-dihydroneopterin uroporphyrinogen-III acyl-carrier protein -D-glucose- a small subunit of glycine betaine glycine betaine spermidine biosynthesis I putrescine 6-phosphate 1-phosphate fructose-1- diphosphoundecaprenyl- diphosphoundecaprenyl- diphosphoundecaprenyl- ECH7EC4206_A1211 family protein: acetyltransferase: alpha subunit diphosphoundecaprenyl- [NAD(P) (2E,6E)-farnesyl uroporphyrinogen-III GTP uroporphyrinogen-III glt glutathione spermidine biosynthesis I ppGpp biosynthesis 1-phosphate lactose trehalose triphosphate peptidoglycan peptidoglycan peptidoglycan cytochrome (acyl-carrier- tyrosine- uroporphyrinogen-III hydroxyethyl)thiazole triphosphate uroporphyrinogen 6-phosphate molybdopterin biosynthesis II (Gram- biosynthesis I (Gram- biosynthesis III glucose-6- N-acetylglucosamine N-acetylglucosamine N-acetylglucosamine GDP-mannose ECH7EC4206_A3917 FadJ: fadJ N-acetylglucosamineasparagine H], large diphosphate hydroxyethylthiazole siroheme D-erythro-7,8- uroporphyrinogen glutathionylspermidine phosphate L-sorbose 1- reductase synthetase synthetase c nitrite rimI protein) phosphatase octaprenyl- decarboxylase: hemE glutamyl-tRNA synthase positive bacteria) negative bacteria) pyruvate kinase II: pykA phosphoenolpyruvate 1-phosphofructokinase: α melibiose degradation synthetase mannosyl synthase: subunit: nirB malonyl-CoA siroheme kinase: thiM synthase: adenosylcobalamin decarboxylase: hemE synthase family protein: phosphate 1- glucose-1- -D-glucose activating acyl-CoA reductase, fatty oxidation dehydratase diphosphate 4-methyl-5-(2- dihydroneopterin GTP α arg SAM pppGpp L-rhamnofuranose fruK phosphate cytoplasmic FtsI: ftsI FtsI: ftsI FtsI: ftsI ribosomal- wzb: wzb methyl ester synthase: cysG coproporphyrinogen III synthetase: gltX -D-glucose choline choline L-ornithine pyruvate kinase I: pykF carboxylase: ppc dehydrogenase: phosphatase: 3'-ketolactose protein: nrdG hydrolase: nudD dehydrogenase: c552 complex, N-acetylmuramoyl-L-asnB FabA: fabA nitrite triphosphate salvage from cobalamin cyclohydrolase coproporphyrinogen III 4'-phosphopantetheinyl [acyl-carrier-protein] ECH7EC4206_A2557 arginine guanosine-5'- fructose-1,6- reductase: trehalase protein-alanine synthase:all-trans ispB- phosphonooxyethyl) Glu melibiose penicillin- penicillin- penicillin- alanyl-D-isoglutaminyl- low molecular cysG precorrin-1 an L-glutamyl-[tRNA ] 6-phosphate alcohol choline S-adenosylmethionine ornithine triphosphate,3'- zwf agp α-D-glucose bisphosphate ECH7EC4206_A0661 subunit: nrfA alpha subunit reductase 4-hydroxybenzoate octaprenyl thiazole epimerase: folX II: ribA coproporphyrinogen transferase acpT: acpT phosphodiesterase: glutathionylspermidine decarboxylase: speA sorE TreF: treF pyruvate acetyltransferase: β beta- weight protein- precorrin-1 7,8-dihydromonapterin cob(I)alamin 2,5-diamino-6- coproporphyrinogen a carboxy- dehydrogenase dehydrogenase: decarboxylase: speD decarboxylase, 6-phospho- beta- alpha- binding binding binding GDP D-mannose FadB: fadB N-( -D-asparaginyl)-L- [NAD(P) thiamine-phosphate III oxidase, acpH amidase/ S-adenosyl-L- diphosphate pyruvate oxaloacetate [+ 2 isozymes] 6-phosphate formate-lyase a 2-enoyl-CoA [+ 2 isozymes] rimJ hydroxyacyl- diphosphate siroheme triphosphate [+ 3 isozymes] biodegradative II: adhB betA putrescine constitutive: speC guanosine-3',5'- D-glucono- L-sorbose 1- galactosidase, galactosidase: melA protein protein protein a ribosomal (R)-3- lysyl-D-alanyl-D-alanine- tyrosine- cob(I)yrinic acid a,c-diamide (5-phospho-D- III oxidase, glutamyl-tRNA glutathionylspermidine adenylated diphosphatase: gppA 1-activating di-trans,octa-cis di-trans,octa-cis di-trans,octa-cis a peptidoglycan a reduced H], small siroheme 4-hydroxybenzoate pyrophosphorylase: synthase: aerobic: hemF arginine methioninamine putrescine bis(diphosphate) 3'- 1,5-lactone L-rhamnono- phosphate reductase: subunit β-D-glucose α-D-galactose β-D-glucose 1B:a peptidoglycan mrcB a peptidoglycan 1B: mrcB 1B: mrcB nitrite protein-N- hydroxybutanoyl-CoA diphosphoundecaprenyl- (acyl-carrier- phosphatase: a 3-oxoglutaryl- adenosyltransferase: btuR ribosylamino) aerobic: hemF reductase: hemA α [small subunit of [+ 3 isozymes] betaine aldehyde malate dehydrogenase, -undecaprenyl -undecaprenyl -undecaprenyl dimer cytochrome c552 subunit: nirD synthase: polyprenyl thiE cysG synthase: gsp -D-glucose decarboxylase: adiA spermidine diphosphatase: spoT 1,4-lactone D-glucose ECH7EC4206_A3710 alpha: ebgA enzyme: pflA a [formate C dimer (E. faeciums) dimer (S.
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