Electronic Supplementary Material (ESI) for Polymer Chemistry This journal is © The Royal Society of Chemistry 2012

Supporting Information

Thiol and pH Dual-Responsive Dynamic Covalent Shell Cross-Linked

Micelles for Triggered Release of Chemotherapeutic Drugs†

Xianglong Hu,a Hui Li,a Shizhong Luo,*b Tao Liu,a Yanyan Jianga and Shiyong Liu*a

CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China; Anhui Key Laboratory of Functional Molecular Solids and Anhui Key Laboratory of Molecule-based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China

* To whom correspondence should be addressed. E-mail: [email protected], [email protected]

a University of Science and Technology of China b Anhui Normal University

Electronic Supplementary Material (ESI) for Polymer Chemistry This journal is © The Royal Society of Chemistry 2012

PCL -Br PCL43-b-P(OEGMA0.67-co-MAEBA0.33)73 43 M = 4.89 kDa, Mn = 32.6 kDa, Mw/Mn = 1.19 n

Mw/Mn = 1.15

16 20 24 28 32 36 Elution Time / min 

Fig. S1. DMF GPC traces recorded for PCL43-Br and PCL43-b-P(OEGMA0.67-co-

MAEBA0.33)73 diblock copolymer. Electronic Supplementary Material (ESI) for Polymer Chemistry This journal is © The Royal Society of Chemistry 2012

1200

900

600

-3 CMC = 9.6*10 g/L 300

0 Fluorescence Intensity 1E-4 1E-3 0.01 0.1

logCpolymer/ (g/L)

Fig. S2. Plot of emission intensity of Nile red at the emission maxima 615 nm (Ȝex = 550 nm;

slit widths: Ex. 5 nm, Em. 5 nm) as a function of concentration of PCL43-b-

P(OEGMA0.67-co-MAEBA0.33)73 diblock copolymer. Nile red concentration was fixed to be 1.0 u 10-6 M. Electronic Supplementary Material (ESI) for Polymer Chemistry This journal is © The Royal Society of Chemistry 2012



1.0

0.8

0.6 

0.4

0.2 0 50 100 150 200 250 Relative Scattering Intensity Time / min

Fig. S3. Time dependence of relative light scattering intensities recorded for 0.05 g/L aqueous solution of (ż) Non-crosslinked (NCL) micelles and (Ƒ) Shell cross-linked (SCL)

micelles fabricated from PCL43-b-P(OEGMA0.67-co-MAEBA0.33)73 diblock copolymer upon treating with 0.1 g/L lipase at 37 oC.