Extrascoop on Vitamins
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Routine Administration of Vitamin K1 Prophylaxis to the Newborn
Routine Administration of Vitamin K1 Prophylaxis to the Newborn Practice Resource for Health Care Providers July 2016 Practice Resource Guide: ROUTINE ADMINISTRATION OF VITAMIN K1 PROPHYLAXIS TO THE NEWBORN The information attached is the summary of the position statement and the recommendations from the recent CPS evidence-based guideline for routine intramuscular administration of Vitamin K1 prophylaxis to the newborn*: www.cps.ca/documents/position/administration-vitamin-K-newborns Summary Vitamin K deficiency bleeding or VKDB (formerly known as hemorrhagic disease of the newborn or HDNB) is significant bleeding which results from the newborn’s inability to sufficiently activate vitamin K-dependent coagulation factors because of a relative endogenous and exogenous deficiency of vitamin K.1 There are three types of VKDB: 1. Early onset VKDB, which appears within the first 24 hours of life, is associated with maternal medications that interfere with vitamin K metabolism. These include some anticonvulsants, cephalosporins, tuberculostatics and anticoagulants. 2. Classic VKDB appears within the first week of life, but is rarely seen after the administration of vitamin K. 3. Late VKDB appears within three to eight weeks of age and is associated with inadequate intake of vitamin K (exclusive breastfeeding without vitamin K prophylaxis) or malabsorption. The incidence of late VKDB has increased in countries that implemented oral vitamin K rather than intramuscular administration. There are three methods of Vitamin K1 administration: intramuscular, oral and intravenous. The Canadian Paediatric Society (2016)2 and the American Academy of Pediatrics (2009)3 recommend the intramuscular route of vitamin K administration. The intramuscular route of Vitamin K1 has been the preferred method in North America due to its efficacy and high compliance rate. -
Dispensing of Vitamin Products by Retail Pharmacies in South Africa: Implications for Dietitians
South African Journal of Clinical Nutrition 2016; 29(4):133–138 http://dx.doi.org/10.1080/16070658.2016.1219468 SAJCN ISSN 1607-0658 EISSN 2221-1268 Open Access article distributed under the terms of the © 2016 The Author(s) Creative Commons License [CC BY-NC 3.0] http://creativecommons.org/licenses/by-nc/3.0 RESEARCH Dispensing of vitamin products by retail pharmacies in South Africa: Implications for dietitians Ilse Trutera* and Liana Steenkampb a Department of Pharmacy, Drug Utilisation Research Unit (DURU), Nelson Mandela Metropolitan University, Port Elizabeth, South Africa b HIV & AIDS Research Unit, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa *Corresponding author, email: [email protected] Objective: The objective of this study was to analyse the dispensing patterns of vitamins (Anatomical Therapeutic Chemical (ATC) group A11) over a one-year period in a group of community pharmacies in South Africa. Design and setting: A retrospective drug utilisation study was conducted on community pharmacy electronic dispensing records in South Africa recorded in 2013. Outcome measures: All products for ATC subgroup A11 were extracted and analysed. Results: A total of 164 233 vitamin products were dispensed to 84 805 patients (62.64% female patients). Males received on average 2.09 (SD = 2.63) vitamin products per year, compared to 1.84 (SD = 2.13) products for females. Ergocalciferol (A11CC01) was the most often dispensed (37.48% of all vitamin products), followed by plain Vitamin B-complex products (A11EA00) accounting for 32.77%. Ergocalciferol (vitamin D2) is only available on prescription (50 000 IU tablets or 50 000 IU/ml oily drops) in South Africa. -
Vitamin K: Double Bonds Beyond Coagulation Insights Into Differences Between Vitamin K1 and K2 in Health and Disease
International Journal of Molecular Sciences Review Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease Maurice Halder 1,†, Ploingarm Petsophonsakul 2,†, Asim Cengiz Akbulut 2,†, Angelina Pavlic 2,† , Frode Bohan 3, Eric Anderson 3, Katarzyna Maresz 4, Rafael Kramann 1 and Leon Schurgers 1,2,* 1 Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany; [email protected] (M.H.); [email protected] (R.K.) 2 Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands; [email protected] (P.P.); [email protected] (A.C.A.); [email protected] (A.P.) 3 NattoPharma ASA, 0283 Oslo, Norway; [email protected] (F.B.); [email protected] (E.A.) 4 International Science & Health Foundation, 30-134 Krakow, Poland; [email protected] * Correspondence: [email protected]; Tel.: +31-43-3881680; Fax: +31-43-3884159 † These authors contributed equally to this work. Received: 24 January 2019; Accepted: 16 February 2019; Published: 19 February 2019 Abstract: Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K can be present in various isoforms, distinguishable by two main structures, namely, phylloquinone (K1) and menaquinones (K2). The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Although differing in structure, both act as cofactor for the enzyme gamma-glutamylcarboxylase, encompassing both hepatic and extrahepatic activity. Only carboxylated proteins are active and promote a health profile like hemostasis. Furthermore, vitamin K2 in the form of MK-7 has been shown to be a bioactive compound in regulating osteoporosis, atherosclerosis, cancer and inflammatory diseases without risk of negative side effects or overdosing. -
Eating Well to Prevent Vitamin B12 Deficiency
www.healthinfo.org.nz Eating well to prevent vitamin B12 deficiency Vitamin B12 helps keep your body's nerve and blood cells healthy. It helps make DNA, the genetic material in your cells. It also helps prevent a type of anaemia that can make you feel tired and weak. Causes of vitamin B12 deficiency Normally, your stomach and intestines digest and absorb vitamin B12 from your food. Vitamin B12 deficiency happens when your stomach and intestines can't absorb the vitamin. This can happen if any of the following apply. ▪ You have pernicious anaemia. This is where your body destroys the cells in your stomach that help you absorb vitamin B12. ▪ You have had surgery to remove part of your stomach or the last part of your small intestine. ▪ You have a digestive disorder such as coeliac disease or Crohn's disease. ▪ You are on certain long-term medications that make it harder for your body to absorb vitamin B12. These medications include antacids, heartburn medicines such as omeprazole and pantoprazole, and metformin. ▪ You are 65 or older. Vitamin B12 deficiency can also happen if you don't eat enough foods with vitamin B12. Most people in New Zealand get plenty of vitamin B12 from food. But some people might not get enough. These people include: ▪ vegans or strict vegetarians ▪ babies who are breastfed by mothers who are vegan or strict vegetarians ▪ people who eat little or no animal foods ▪ older people who have a poor appetite and eat very small meals. Treating vitamin B12 deficiency Vitamin B12 deficiency is diagnosed through a blood test. -
Control of Interstitial Pneumonia by Drip Infusion of Megadose Vitamin C, Dehydroepiandrosterone and Cortisol
in vivo 22 : 263-268 (2008) Short Review Control of Interstitial Pneumonia by Drip Infusion of Megadose Vitamin C, Dehydroepiandrosterone and Cortisol. A Short Review of our Experience MITSUO KODAMA 1, ATSUSHI OYAMA 2 and HIROSHI TAKAGI 3 1Kodama Research Institute of Preventive Medicine, 2Hikarigaoka Clinic, and 3Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan Abstract. Interstitial pneumonia can be controlled by the granulatory tissue (1). The interstitial tissues are also combined use of a prophylactic antibiotic system and the drip involved in the site of granulation (1). All these descriptions infusion system including megadose vitamin C, dehydro- are in good agreement with the pathological changes of epiandrosterone (D) and cortisol (F), a fortified substitute of 3 interstitial pneumonia (2). In the treatment section, adrenocortical elements. The response of patients was satisfying Heilmeyer warned of the possible emergence of antibiotic with few side-effects of F. It was shown that an excess of resistance in local bacteria (1). Eventually, cortisone and vitamin C improved the therapeutic efficacy of D-F complex, adrenocorticotropic hormone (ACTH) could be tried under and that D and F improved the immunodeficient state of the the antibiotic protection (1). Above all, attention should be host. The benefit of D as an adrenal androgen in immunology directed to the control of both the heart and the general found another example in the combined use of cyclosporine A circulation system (1). With the use of cortisone and ACTH, (CS) and glucocorticoid (G) in the kidney transplantation Heilmeyer might have been inspired by the opinion of a clinic: CS and G helps improve graft take by creating a state of group of researchers that his chronic pneumonia might androgen excess, as testified in both humans and mice – an respond to a beneficial action of glucocorticoid, as is the alleviation of immune conflict. -
Folic Acid, Pyridoxine, and Cyanocobalamin Combination
ORIGINAL INVESTIGATION Folic Acid, Pyridoxine, and Cyanocobalamin Combination Treatment and Age-Related Macular Degeneration in Women The Women’s Antioxidant and Folic Acid Cardiovascular Study William G. Christen, ScD; Robert J. Glynn, ScD; Emily Y. Chew, MD; Christine M. Albert, MD; JoAnn E. Manson, MD Background: Observational epidemiologic studies indi- and visually significant AMD, defined as confirmed in- cate a direct association between homocysteine concentra- cident AMD with visual acuity of 20/30 or worse attrib- tion in the blood and the risk of age-related macular degen- utable to this condition. eration (AMD), but randomized trial data to examine the effect of therapy to lower homocysteine levels in AMD are Results:Afteranaverageof7.3yearsoftreatmentandfollow- lacking. Our objective was to examine the incidence of AMD up, there were 55 cases of AMD in the combination treat- in a trial of combined folic acid, pyridoxine hydrochloride ment group and 82 in the placebo group (relative risk, 0.66; (vitamin B6), and cyanocobalamin (vitamin B12) therapy. 95% confidence interval, 0.47-0.93 [P=.02]). For visually significant AMD, there were 26 cases in the combination Methods: We conducted a randomized, double-blind, treatment group and 44 in the placebo group (relative risk, placebo-controlled trial including 5442 female health care 0.59; 95% confidence interval, 0.36-0.95 [P=.03]). professionals 40 years or older with preexisting cardio- vascular disease or 3 or more cardiovascular disease risk Conclusions: These randomized trial data from a large factors. A total of 5205 of these women did not have a cohort of women at high risk of cardiovascular disease diagnosis of AMD at baseline and were included in this indicate that daily supplementation with folic acid, pyri- analysis. -
Is There an Ideal Diet to Protect Against Iodine Deficiency?
nutrients Review Is There an Ideal Diet to Protect against Iodine Deficiency? Iwona Krela-Ka´zmierczak 1,† , Agata Czarnywojtek 2,3,†, Kinga Skoracka 1,* , Anna Maria Rychter 1 , Alicja Ewa Ratajczak 1 , Aleksandra Szymczak-Tomczak 1, Marek Ruchała 2 and Agnieszka Dobrowolska 1 1 Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Heliodor Swiecicki Hospital, 60-355 Poznan, Poland; [email protected] (I.K.-K.); [email protected] (A.M.R.); [email protected] (A.E.R.); [email protected] (A.S.-T.); [email protected] (A.D.) 2 Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland; [email protected] (A.C.); [email protected] (M.R.) 3 Department of Pharmacology, Poznan University of Medical Sciences, 60-806 Poznan, Poland * Correspondence: [email protected]; Tel.: +48-665-557-356 or +48-8691-343; Fax: +48-8691-686 † These authors contributed equally to this work. Abstract: Iodine deficiency is a global issue and affects around 2 billion people worldwide, with preg- nant women as a high-risk group. Iodine-deficiency prevention began in the 20th century and started with global salt iodination programmes, which aimed to improve the iodine intake status globally. Although it resulted in the effective eradication of the endemic goitre, it seems that salt iodination did not resolve all the issues. Currently, it is recommended to limit the consumption of salt, which is the main source of iodine, as a preventive measure of non-communicable diseases, such as hypertension or cancer the prevalence of which is increasing. -
R Graphics Output
Dexamethasone sodium phosphate ( 0.339 ) Melengestrol acetate ( 0.282 ) 17beta−Trenbolone ( 0.252 ) 17alpha−Estradiol ( 0.24 ) 17alpha−Hydroxyprogesterone ( 0.238 ) Triamcinolone ( 0.233 ) Zearalenone ( 0.216 ) CP−634384 ( 0.21 ) 17alpha−Ethinylestradiol ( 0.203 ) Raloxifene hydrochloride ( 0.203 ) Volinanserin ( 0.2 ) Tiratricol ( 0.197 ) trans−Retinoic acid ( 0.192 ) Chlorpromazine hydrochloride ( 0.191 ) PharmaGSID_47315 ( 0.185 ) Apigenin ( 0.183 ) Diethylstilbestrol ( 0.178 ) 4−Dodecylphenol ( 0.161 ) 2,2',6,6'−Tetrachlorobisphenol A ( 0.156 ) o,p'−DDD ( 0.155 ) Progesterone ( 0.152 ) 4−Hydroxytamoxifen ( 0.151 ) SSR150106 ( 0.149 ) Equilin ( 0.3 ) 3,5,3'−Triiodothyronine ( 0.256 ) 17−Methyltestosterone ( 0.242 ) 17beta−Estradiol ( 0.24 ) 5alpha−Dihydrotestosterone ( 0.235 ) Mifepristone ( 0.218 ) Norethindrone ( 0.214 ) Spironolactone ( 0.204 ) Farglitazar ( 0.203 ) Testosterone propionate ( 0.202 ) meso−Hexestrol ( 0.199 ) Mestranol ( 0.196 ) Estriol ( 0.191 ) 2,2',4,4'−Tetrahydroxybenzophenone ( 0.185 ) 3,3,5,5−Tetraiodothyroacetic acid ( 0.183 ) Norgestrel ( 0.181 ) Cyproterone acetate ( 0.164 ) GSK232420A ( 0.161 ) N−Dodecanoyl−N−methylglycine ( 0.155 ) Pentachloroanisole ( 0.154 ) HPTE ( 0.151 ) Biochanin A ( 0.15 ) Dehydroepiandrosterone ( 0.149 ) PharmaCode_333941 ( 0.148 ) Prednisone ( 0.146 ) Nordihydroguaiaretic acid ( 0.145 ) p,p'−DDD ( 0.144 ) Diphenhydramine hydrochloride ( 0.142 ) Forskolin ( 0.141 ) Perfluorooctanoic acid ( 0.14 ) Oleyl sarcosine ( 0.139 ) Cyclohexylphenylketone ( 0.138 ) Pirinixic acid ( 0.137 ) -
Vitamins Minerals Nutrients
vitamins minerals nutrients Vitamin B12 (Cyanocobalamin) Snapshot Monograph Vitamin B12 Nutrient name(s): (Cyanocobalamin) Vitamin B12 Most Frequent Reported Uses: Cyanocobalamin • Homocysteine regulation Methylcobalamin • Neurological health, including Adenosylcobalamin (Cobamamide) diabetic neuropathy, cognitive Hydroxycobalamin (European) function, vascular dementia, stroke prevention • Anemias, including pernicious and megaloblastic • Sulfite sensitivity Cyanocobalamin Introduction: Vitamin B12 was isolated from liver extract in 1948 and reported to control pernicious anemia. Cobalamin is the generic name of vitamin B12 because it contains the heavy metal cobalt, which gives this water-soluble vitamin its red color. Vitamin B12 is an essential growth factor and plays a role in the metabolism of cells, especially those of the gastrointestinal tract, bone marrow, and nervous tissue. Several different cobalamin compounds exhibit vitamin B12 activity. The most stable form is cyanocobalamin, which contains a cyanide group that is well below toxic levels. To become active in the body, cyanocobalamin must be converted to either methylcobalamin or adenosylcobalamin. Adenosylcobalamin is the primary form of vitamin B12 in the liver. © Copyright 2013, Integrative Health Resources, LLC | www.metaboliccode.com A protein in gastric secretions called intrinsic factor binds to vitamin B12 and facilitates its absorption. Without intrinsic factor, only a small percentage of vitamin B12 is absorbed. Once absorbed, relatively large amounts of vitamin B12 can be stored in the liver. The body actually reabsorbs vitamin B12 in the intestines and returns much of it to the liver, allowing for very little to be excreted from the body. However, when there are problems in the intestines, such as the microflora being imbalanced resulting in gastrointestinal inflammation, then vitamin B12 deficiencies can occur. -
Optimal Foods
Optimal Foods 1. Almonds: high in monounsaturated and polyunsaturated fats, with 20% of calories coming from protein and dietary fiber. Nutrients include potassium, magnesium, calcium, iron, zinc, vitamin E and an antioxidant flavonoid called amygdlin also known as laetrile. 2. Barley: Like oat bran it is high in beta-glucan fiber which helps to lower cholesterol. Nutrients include copper, magnesium, phosphorous and niacin. 3. Berries : The darker the berry the higher in anti-oxidants. Nutritionally they are an excellent source of flavonoids, especially anthocyanidins, vitamin C and both soluble and insoluble fiber. 4. Brussels Sprouts : Similar to broccoli, and a member of the cabbage family, it contains cancer fighting glucosinolates. Nutritionally it is an excellent source of vitamin C and K, the B vitamins, beta-carotene, potassium and dietary fiber. 5. Carrots: It contains the highest source of proviatamin A carotenes as well as vitamin K, biotin, vitamin C, B6, potassium, thiamine and fiber. 6. Dark Chocolate: It is rich in the flavonoids, similar to those found in berries and apples, that are more easily absorbed than in other foods. It also provides an amino acid called arginine that helps blood vessels to dilate hence regulating blood flow and helping to lower blood pressure. Choose high-quality semisweet dark chocolate with the highest cocoa content that appeals to your taste buds. 7. Dark leafy greens : Kale, arugula, spinach, mustard greens, chard, collards, etc: low calorie, anti-oxidant dense food with carotenes, vitamin C, folic acid, manganese, copper, vitamin E, copper, vitamin B6, potassium, calcium, iron and dietary fiber. Kale is a particularly excellent bioavailable source of calcium while spinach is not. -
Guidelines on Food Fortification with Micronutrients
GUIDELINES ON FOOD FORTIFICATION FORTIFICATION FOOD ON GUIDELINES Interest in micronutrient malnutrition has increased greatly over the last few MICRONUTRIENTS WITH years. One of the main reasons is the realization that micronutrient malnutrition contributes substantially to the global burden of disease. Furthermore, although micronutrient malnutrition is more frequent and severe in the developing world and among disadvantaged populations, it also represents a public health problem in some industrialized countries. Measures to correct micronutrient deficiencies aim at ensuring consumption of a balanced diet that is adequate in every nutrient. Unfortunately, this is far from being achieved everywhere since it requires universal access to adequate food and appropriate dietary habits. Food fortification has the dual advantage of being able to deliver nutrients to large segments of the population without requiring radical changes in food consumption patterns. Drawing on several recent high quality publications and programme experience on the subject, information on food fortification has been critically analysed and then translated into scientifically sound guidelines for application in the field. The main purpose of these guidelines is to assist countries in the design and implementation of appropriate food fortification programmes. They are intended to be a resource for governments and agencies that are currently implementing or considering food fortification, and a source of information for scientists, technologists and the food industry. The guidelines are written from a nutrition and public health perspective, to provide practical guidance on how food fortification should be implemented, monitored and evaluated. They are primarily intended for nutrition-related public health programme managers, but should also be useful to all those working to control micronutrient malnutrition, including the food industry. -
Validation of Hplc Method for Determination of Thiamine Hydrochloride, Riboflavin, Nicotinamide, and Pyridoxine Hydrochl0ride in Syrup Preparation
Canadian Journal on Scientific and Industrial Research Vol. 2 No. 7, August 20ll VALIDATION OF HPLC METHOD FOR DETERMINATION OF THIAMINE HYDROCHLORIDE, RIBOFLAVIN, NICOTINAMIDE, AND PYRIDOXINE HYDROCHL0RIDE IN SYRUP PREPARATION NOVI YANTIH*, DIAH WIDOWATI, WARTINI, TIWI ARYANI Faculty of Pharmacy, University of Pancasila Email: novi_yantih @ yahoo.com Faculty of Pharmacy, University of Pancasila, Srengseng Sawah, Jagakarsa, 12640 South Jakarta, Indonesia ABSTRACT Multivitamin syrup containing various substances of varying characteristics may have a problem in quantitative analysis. This research has developed and validated of HPLC method for determination of four vitamin components, that is thiamine hydrochloride, riboflavin, nicotinamide, and pyridoxine hydrochloride in syrup multivitamin-mineral. The chromatographic separation was achieved by using a C18 column with dimension of 3.9x300mm and particle size of l0µm. A mixture of methanol - l% acetic acid by using 7mM 1-hexane sulphonic acid sodium salt (20:80) as mobile phase with flow rate of 1 mL/min. The effluent was monitored at 280 nm. Effective separation and quantification was achieved in less than 20 min. That method was simple, accurate, precise, and could be successfully applied for the analysis of thiamine hydrochloride, riboflavin, nicotinamide, and pyridoxine hydrochloride syrup multivitamin- mineral. Keywords: Thiamine hydrochloride, riboflavin, nicotinamide, pyridoxine hydrochloride, syrup, HPLC. 269 270 INTRODUCTION Syrup multivitamin and mineral preparations containing various substances of varying characteristics may have many problems in quantitative analysis. High performance liquid chromatography (HPLC) due to its high capacity in separating a mixture of substances was applicable in determining each component in multivitamin preparations simultaneously. Several investigator have reported the used of HPLC methods for the determination of water-soluble vitamins, such as thiamine hydrochloride, riboflavin, nicotinarnide, and pyridoxine hydrochloride in pharmaceuticals preparations [l,2,3].