Biomolecular Engineering Long-Range Plan
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Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond
This PDF is available from The National Academies Press at http://www.nap.edu/catalog.php?record_id=18722 Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond ISBN Committee on Key Challenge Areas for Convergence and Health; Board on 978-0-309-30151-0 Life Sciences; Division on Earth and Life Studies; National Research Council 156 pages 6 x 9 PAPERBACK (2014) Visit the National Academies Press online and register for... Instant access to free PDF downloads of titles from the NATIONAL ACADEMY OF SCIENCES NATIONAL ACADEMY OF ENGINEERING INSTITUTE OF MEDICINE NATIONAL RESEARCH COUNCIL 10% off print titles Custom notification of new releases in your field of interest Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Request reprint permission for this book Copyright © National Academy of Sciences. All rights reserved. Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond Prepublication Copy Subject to Further Editorial Revisions Convergence Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond Committee on Key Challenge Areas for Convergence and Health Board on Life Sciences Division on Earth and Life Studies THE NATIONAL ACADEMIES PRESS Washington, D.C. www.nap.edu Copyright © National Academy of Sciences. All rights reserved. Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. -
Engines of Creation : the Coming Era of Nanotechnology K
Engines of Creation : The Coming Era of Nanotechnology K. Eric. Drexler, Anchor Books, Doubleday, 1986 (downloaded from : http://www.foresight.org/EOC/EOC_Chapter_1.html) Chapter 1 : ENGINES OF CONSTRUCTION COAL AND DIAMONDS, sand and computer chips, cancer and healthy tissue: throughout history, variations in the arrangement of atoms have distinguished the cheap from the cherished, the diseased from the healthy. Arranged one way, atoms make up soil, air, and water; arranged another, they make up ripe strawberries. Arranged one way, they make up homes and fresh air; arranged another, they make up ash and smoke. Our ability to arrange atoms lies at the foundation of technology. We have come far in our atom arranging, from chipping flint for arrowheads to machining aluminum for spaceships. We take pride in our technology, with our lifesaving drugs and desktop computers. Yet our spacecraft are still crude, our computers are still stupid, and the molecules in our tissues still slide into disorder, first destroying health, then life itself. For all our advances in arranging atoms, we still use primitive methods. With our present technology, we are still forced to handle atoms in unruly herds. But the laws of nature leave plenty of room for progress, and the pressures of world competition are even now pushing us forward. For better or for worse, the greatest technological breakthrough in history is still to come. Two Styles Of Technology Our modern technology builds on an ancient tradition. Thirty thousand years ago, chipping flint was the high technology of the day. Our ancestors grasped stones containing trillions of trillions of atoms and removed chips containing billions of trillions of atoms to make their axheads; they made fine work with skills difficult to imitate today. -
Department of Chemical and Biomolecular Engineering 1
Department of Chemical and Biomolecular Engineering 1 Department of Chemical and Biomolecular Engineering Vasan Venugopalan, Department Chair 6000 Interdisciplinary Science & Engineering Bldg. (ISEB) 949-824-6412 http://www.eng.uci.edu/dept/cbe (http://www.eng.uci.edu/dept/cbe/) The Department of Chemical and Biomolecular Engineering offers the B.S. in Chemical Engineering, and the M.S. and Ph.D. in Chemical and Biomolecular Engineering. Chemical Engineering uses knowledge of chemistry, mathematics, physics, biology, and humanities to solve societal problems in areas such as energy, health, the environment, food, clothing, materials, and sustainability and serves a variety of processing industries whose vast array of products include chemicals, petroleum products, plastics, pharmaceuticals, foods, textiles, fuels, consumer products, and electronic and cryogenic materials. Chemical Engineering also advances societal goals by developing environmentally conscious and sustainable technologies to meet global challenges. The undergraduate curriculum in Chemical Engineering builds on basic courses in chemical engineering, other branches of engineering, and electives which provide a strong background in humanities and human behavior. Elective programs developed by the student with a faculty advisor may include such areas as applied chemistry, biomolecular engineering, chemical reaction engineering, chemical processing, environmental engineering, materials science, process control systems engineering, and biomedical engineering. • Chemical and -
The for Report 07-08
THE CENTER FOR INTEGRATIVE GENOMICS REPORT 07-08 www.unil.ch/cig Table of Contents INTRODUCTION 2 The CIG at a glance 2 The CIG Scientific Advisory Committee 3 Message from the Director 4 RESEARCH 6 Richard Benton Chemosensory perception in Drosophila: from genes to behaviour 8 Béatrice Desvergne Networking activity of PPARs during development and in adult metabolic homeostasis 10 Christian Fankhauser The effects of light on plant growth and development 12 Paul Franken Genetics and energetics of sleep homeostasis and circadian rhythms 14 Nouria Hernandez Mechanisms of basal and regulated RNA polymerase II and III transcription of ncRNA in mammalian cells 16 Winship Herr Regulation of cell proliferation 18 Henrik Kaessmann Mammalian evolutionary genomics 20 Sophie Martin Molecular mechanisms of cell polarization 22 Liliane Michalik Transcriptional control of tissue repair and angiogenesis 24 Alexandre Reymond Genome structure and expression 26 Andrzej Stasiak Functional transitions of DNA structure 28 Mehdi Tafti Genetics of sleep and the sleep EEG 30 Bernard Thorens Molecular and physiological analysis of energy homeostasis in health and disease 32 Walter Wahli The multifaceted roles of PPARs 34 Other groups at the Génopode 37 CORE FACILITIES 40 Lausanne DNA Array Facility (DAFL) 42 Protein Analysis Facility (PAF) 44 Core facilities associated with the CIG 46 EDUCATION 48 Courses and lectures given by CIG members 50 Doing a PhD at the CIG 52 Seminars and symposia 54 The CIG annual retreat 62 The CIG and the public 63 Artist in residence at the CIG 63 PEOPLE 64 1 Introduction The Center for IntegratiVE Genomics (CIG) at A glance The Center for Integrative Genomics (CIG) is the newest depart- ment of the Faculty of Biology and Medicine of the University of Lausanne (UNIL). -
To Undergraduate Studies in Chemistry, Chemical Engineering, and Chemical Biology College of Chemistry, University of California, Berkeley, 2011-12
Guide to Undergraduate Studies in Chemistry, Chemical Engineering, and -2012 Chemical Biology College of Chemistry 2011 University of California, Berkeley Academic Calendar 2011-12 Fall Semester 2011 Tele-BEARS Begins April 11 Monday Fee Payment Due August 15 Monday Fall Semester Begins August 18 Thursday Welcome Events August 22-26 Monday-Friday Instruction Begins August 25 Thursday Labor Day Holiday September 5 Monday Veterans Day Holiday November 11 Friday Thanksgiving Holiday November 24-25 Thursday-Friday Formal Classes End December 2 Friday Reading/Review/Recitation Week December 5-9 Monday-Friday Final Examinations December 12-16 Monday-Friday Fall Semester Ends December 16 Friday Winter Holiday December 26-27 Monday-Tuesday New Year’s Holiday December 29-30 Thursday-Friday Spring Semester 2012 Tele-BEARS Begins October 17, 2011 Monday Spring Semester Begins January 10 Tuesday Fee Payment Due January 15 Sunday Martin Luther King Jr. Holiday January 16 Monday Instruction Begins January 17 Tuesday Presidents’ Day Holiday February 20 Monday Spring Recess March 26-30 Monday-Friday César Chávez Holiday March 30 Friday Cal Day To Be Determined Formal Classes End April 27 Friday Reading/Review/Recitation Week April 30-May 4 Monday-Friday Final Examinations May 7-11 Monday-Friday Spring Semester Ends May 11 Friday Summer Sessions 2012 Tele-BEARS Begins February 6 Monday First Six-Week Session May 21-June 29 Monday-Friday Memorial Day Holiday May 28 Monday Ten-Week Session June 4-August 10 Monday-Friday Eight-Week Session June 18-August -
Amfep Fact Sheet on Protein Engineered Enzymes
Amfep/09/1 7 Brussels , 07 .0 5.2009 Amfep Fact Sheet on Protein Engineered Enzymes Protein engineering is a technique to change the amino acid sequence of proteins in order to improve their specific properties. This paper addresses the background of this technique, why it is used in the case of industrial enzymes, as well as regulatory and safety aspects. Natural evolution, biodiversity and traditional methods of improving industrial enzyme proteins All proteins, including enzymes, are based on the same 20 different amino acid building blocks arranged in different sequences. Enzyme proteins typically comprise sequences of several hundred amino acids folded in a unique three-dimensional structure. Only the sequence of these 20 building blocks determines the three-dimensional structure, which in turn determines all properties such as catalytic activity, specificity and stability. Nature has been performing ‘protein engineering’ for billions of years since the very start of evolution. Natural spontaneous mutations in the DNA coding for a given protein result in changes of the protein structure and hence its properties. This natural variation is part of the adaptive evolutionary process continuously taking place in all living organisms, allowing them to survive in continously changing environments. Natural variants of enzyme proteins are adapted to perform efficiently in different environments and conditions. This explains why in nature enzymes belonging to the same enzyme family but isolated from different organisms and environments often show a variation in amino acid sequence of more than 50%. The properties of enzymes used for industrial purposes sometimes also require some adaptations in order to function more effectively in applications for which they were not designed by nature. -
Engineering at Johns Hopkins University! We Look Forward to Meeting You When You Arrive on Campus for Orientation
Eng in eering 1 01 2019-2020 p rogr am p lanni ng gui de for fi rst-y ear e ngi neering s tudents Welcome to the Whiting School of Engineering at Johns Hopkins University! We look forward to meeting you when you arrive on campus for orientation. In the meantime, we have prepared the First-Year Academic Guide and Engineering 101 to get you started. The Academic Guide includes information for all first-year students at Hopkins, while Engineering 101 is directed specifically to engineering students. Engineering 101 contains information about all of the majors in the School of Engineering, including recommended first semester class schedules. You’ll also find out about some opportunities to join student groups. We hope that these materials help you learn about the Hopkins community and the options available to you. Again, welcome to Hopkins and we’ll see you in August! Linda Moulton, Denise Shipley, Lashell Silver, Eric Simmons, Janet Weise, and Betty Zee Johns Hopkins University Whiting School of Engineering Office of Academic Affairs—Engineering Advising Wyman Park Building Suite N125 3400 N. Charles Street Baltimore, MD 21218-2681 410-516-7395 [email protected] https://engineering.jhu.edu/advising/ Nondiscrimination Statement The Johns Hopkins University is committed to equal opportunity and providing a safe and non- discriminatory educational and working environment for its students, trainees, faculty, staff, post-doctoral fellows, residents, and other members of the University community. To that end, the university seeks to provide community members with an environment that is free from discrimination and harassment on the basis of sex, gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status or other legally protected characteristic. -
Technical Expertise
Technical Expertise Kilpatrick Townsend’s large patent practice is characterized by a large depth and breadth of technical experience. The below list sets forth representative technical and industry expertise of selected partners & counsel who are available to work on patent due diligence matters and does not include the still wider wide range of expertise among our associates and patent agents. Many of the professionals highlighted below have expertise across multiple technical disciplines, but we have indicated areas that illustrate the diversity of our overall technical expertise. If you don’t see a technology/industry listed that you are interested in, we likely have expertise – please ask us. Electronics & Software Aeronautics Mark Mathison, M.S. in Aeronautical Engineering (also has expertise in electromechanical devices, software, Internet, network, e-commerce). AI (Artificial Intelligence) Kate Gaudry, Ph.D. in Computational Neurobiology (also expertise in software, computers, and quantitative-biology). Rob Curylo, B.S. Electrical Engineering (also has expertise in machine learning for online marketing and credit risk assessment, & as workflow and machine-learning solutions for image and video editing). Autonomous Vehicles Ko-Fang Chang, former engineer at ViaSat (also has expertise in mobile devices and applications, wireless communications, networking and computer architecture). Bioinformatics Dave Raczkowski, Ph.D. in Physics (also has expertise in medical diagnostics, image processing, machine learning, databases and cloud computing; programmable logic, computer hardware, networking, energy management, nanotechnology, power supplies, and financial transactions and other Internet commerce). Blockchain (Cryptocurrency) Tom Franklin, former engineer at Lockeed & Hughes Electronics (also has expertise in Internet technology, content delivery, business methods, clean technology, circuit design, imaging arrays, cryptographic design, telecommunications, electronic design tools, wireless communications, networking and telemetry systems). -
Biomolecular Engineering for Nanobio/Bionanotechnology
Nagamune Nano Convergence (2017) 4:9 DOI 10.1186/s40580-017-0103-4 REVIEW Open Access Biomolecular engineering for nanobio/ bionanotechnology Teruyuki Nagamune* Abstract Biomolecular engineering can be used to purposefully manipulate biomolecules, such as peptides, proteins, nucleic acids and lipids, within the framework of the relations among their structures, functions and properties, as well as their applicability to such areas as developing novel biomaterials, biosensing, bioimaging, and clinical diagnostics and therapeutics. Nanotechnology can also be used to design and tune the sizes, shapes, properties and functionality of nanomaterials. As such, there are considerable overlaps between nanotechnology and biomolecular engineering, in that both are concerned with the structure and behavior of materials on the nanometer scale or smaller. Therefore, in combination with nanotechnology, biomolecular engineering is expected to open up new felds of nanobio/ bionanotechnology and to contribute to the development of novel nanobiomaterials, nanobiodevices and nanobio- systems. This review highlights recent studies using engineered biological molecules (e.g., oligonucleotides, peptides, proteins, enzymes, polysaccharides, lipids, biological cofactors and ligands) combined with functional nanomaterials in nanobio/bionanotechnology applications, including therapeutics, diagnostics, biosensing, bioanalysis and biocata- lysts. Furthermore, this review focuses on fve areas of recent advances in biomolecular engineering: (a) nucleic acid engineering, -
“Biomaterials for Tissue Engineering and Regenerative Medicine” Antonios G
Coulter Seminar Series Presents “Biomaterials for Tissue Engineering and Regenerative Medicine” Antonios G. Mikos, PhD Louis Calder Professor of Bioengineering, Chemical & Biomolecular Engineering Department of Bioengineering Rice University, Houston, Texas Antonios G. Mikos is the Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering at Rice University. He is the Director of the J.W. Cox Laboratory for Biomedical Engineering and the Director of the Center for Excellence in Tissue Engineering at Rice University. His research focuses on the synthesis, processing, and evaluation of new biomaterials for use as scaffolds for tissue engineering, as carriers for controlled drug delivery, and as non-viral vectors for gene therapy. His work has led to the development of novel orthopaedic, dental, cardiovascular, neurologic, and ophthalmologic biomaterials. He is the author of over 580 publications and the inventor of 29 patents. Mikos is a Member of the National Academy of Engineering, the National Academy of Medicine, the National Academy of Inventors, the Academy of Medicine, Engineering and Science of Texas, and the Academy of Athens. He has been recognized by various awards including the Lifetime Achievement Award of the Tissue Engineering and Regenerative Medicine International Society-Americas and the Founders Award of the Society For Biomaterials. He is a founding editor and editor-in-chief of the journal Tissue Engineering. ABSTRACT Advances in biology, materials science, chemical engineering, and other fields have allowed for the development of tissue engineering, an interdisciplinary convergence science. For the past two and a half decades, our laboratory has focused on the development and characterization of biomaterials-based strategies for the regeneration of human tissues with the goal of improving healthcare outcomes. -
Research and Creative Activity
Research and Creative Activity 2008 Major Sponsored Programs and Faculty Awards for Research and Creative Activity Office of Research University of Nebraska–Lincoln ® 3 Awards of $3 million or more 16 Awards of $1 million to $2,999,999 24 Awards of $200,000 to $999,999 58 Early Career Awards 62 Arts and Humanities Awards of $50,000 or more 65 Arts and Humanities Awards of $5,000 to $49,999 67 Patents Issued 69 Intellectual Property Licences 71 Creative Works in Fine and Performing Arts 74 Books 87 Recognitions and Honors 95 Glossary of Federal Agency Abbreviations On the Cover: Climate change is a global concern with potential to alter the life and landscape of Nebraska and the High Plains. On the cover, a thunderstorm moves toward the Upstream Ranch along the Calamus River in Nebraska’s Sandhills, one of the fragile ecosystems that could see significant impacts of climate change. Diverse research by UNL scientists is expanding our understanding of climate change and providing tools to help preserve the region’s long-term sustainability. UNL is partnering with the U.S. Geological Survey to explore developing a regional climate change research framework. Chancellor Harvey Perlman and Vice Chancellor Prem Paul This is the seventh annual “Major Sponsored Programs and Faculty Awards for Research and Creative Activity” report. This booklet highlights the successes of University of Nebraska–Lincoln faculty during 2008. It lists the funding sources, projects and investigators on major grants and sponsored program awards received during the year, as well as patents issued; published books and scholarship; fellowships and other recognitions; intellectual property licenses; and performances and exhibitions in the fine and performing arts. -
Protein Nanotechnology
PROTEIN NANOTECHNOLOGY Jayachandra S. Yaradoddi1,2,6*, Merja Kontro2, Sharanabasava V. Ganachari1, Sulochana M. B.3 Dayanand Agsar4, Rakesh Tapaskar5 and Ashok S. Shettar1 1,2Centre for Material Science, Advanced research in Nanoscience & Nanotechnology, KLE Technological University, Hubballi and Dept. of Environmental Sciences, University of Helsinki, Finland, 3Department of PG Studies and Research in Biotechnology, Gulbarga University, Kalaburagi-585106, INDIA 4Department of PG Studies and Research in Microbiology, Gulbarga University, Kalaburagi-585106, INDIA 5School of Mechanical Engineering KLE Technological University, Hubballi-580031, INDIA 6Extremz Biosciences private limited, CTIE start up street, KLE Technology University campus, Hubballi-580031 Abstract: Medical management is to be preserved well, especially diagnosis is fast, easy and cheap. Sometimes RNA and DNA nanobio-based diagnostic may not give the precise data in respect to specific disorders. Therefore, some quantifiable protein information and molecular folding are very much required for the analysis of such disorders. Proteins in minute concentration is typically not detectable under the normal circumstances. Nowadays which can be measured and quantified using protein nanotechnology methods. On the other side protein machineries brings out the tasks unsafe to cell behavior, comprises DNA duplication, intracellular carriage, ion pump, cellular motility. They have changed unbelievable multiplicity, precision, efficacy and a substantial quantity of study in contemporary biology intended to expose the vital mechanisms or processes primarily their function. This chapter also emphasizes the recent development in protein nanotechnology with special focus on molecular cytoskeletal motors, dyneins, myosin’s and kinesins. They constitute subcategory of the protein machineries, they have distinguished properties and can be able to convert biochemical energy directly to automatic work.