Michele Castellana

Personal information

Date of birth June 8 1983 Citizenship Italian Current address Carl Icahn Laboratory, Room 140, Princeton, NJ 08544, United States. Telephone number +1 609 258 8395 Email address [email protected], [email protected] Mother Tongue Italian Other languages English (fluent), French (fluent). Webpage http://scholar.princeton.edu/michelec/

Education

Dates 2011 - present Title of qualification Postdoctoral Research Associate Institution Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States Supervisor William Bialek (Lewis-Sigler Institute for Integrative Genomics)

Dates 2007 - 2011 Title of qualification Ph.D. in Physics. Thesis title: The Renormalization Group for Disordered Systems Institution University La Sapienza, , and University Paris Sud, Orsay, France Supervisors Giorgio Parisi (University La Sapienza), Marc Mézard (University Paris Sud)

Dates 2005 - 2007 Title of qualification awarded Graduate studies in Institution University La Sapienza, Rome, Italy Supervisor Remo Ruffini (University La Sapienza) Mark 110 / 110 with honors

1 Michele Castellana 2

Dates 2002 - 2005 Title of qualification awarded Bachelor of Science in Physics Institution University La Sapienza, Rome, Italy Supervisor Guido Martinelli (University La Sapienza) Mark 110 / 110 with honors

Dates 1997 - 2002 Title of qualification awarded Diploma of secondary school focusing on humanities Institution E. Q. Visconti high school, Rome, Italy Mark 100 / 100

Scholarships and awards

Date 2014 Title of award Winner of the doctoral-thesis award at University La Sapienza, Rome, Italy. Date 2009 Title of award Winner of the Vinci scholarship of the French-Italian University. Date 2008 Title of award First named for Ph.D. at University La Sapienza, Rome, Italy. Date 2008 Title of award First named for Ph.D. at International School for Advanced Studies (ISAS), Trieste, Italy.

Publications in peer-reviewed journals

1. M. Castellana and G. Parisi Non-perturbative effects in spin glasses Scientific Reports 5, 8697 (2015). 2. M. Castellana and C. Barbieri Hierarchical spin glasses in a magnetic field: A renormalization-group study Physical Review B 91(2), 024202 (2015).

3. M. Castellana, M. Z. Wilson, Y. Xu, P. Joshi, I. M. Cristea, J. D. Rabinowitz, Z. Gitai and N. S. Wingreen Enzyme clustering accelerates processing of intermediates through metabolic channeling Nature Biotechnology 32(10), 1011 (2014) Michele Castellana 3

4. M. Castellana and W. Bialek Inverse spin glass and related maximum entropy problems Physical Review Letters 113(11), 117204 (2014). 5. M. Castellana Rigorous results for hierarchical models of structural glasses Journal of Statistical Physics 157(2), 219 (2014). 6. M. Castellana Extreme-value distributions and the freezing transition of structural glasses Physical Review Letters 112(21), 215701 (2014).

7. M. Castellana, A. Barra and F. Guerra Free-energy bounds for hierarchical spin models Journal of Statistical Physics 155(2), 211 (2014). 8. M. Castellana, A. Decelle and E. Zarinelli Extreme value statistics distributions in spin glasses Physical Review Letters 107(27), 275701 (2011).

9. M. Castellana and E. Zarinelli Role of Tracy-Widom distribution in finite-size fluctuations of the critical temperature of the Sherrington-Kirkpatrick spin glass Physical Review B 84(14), 144417 (2011).

10. M. Castellana Real-space renormalization group analysis of a non-mean-field spin-glass Europhysics Letters 95(4), 47014 (2011). 11. M. Castellana and G. Parisi Renormalization-group computation of the critical exponents of hierarchical spin glasses: Large- scale behavior and divergence of the correlation length Physical Review E 83(4), 041134 (2011). 12. M. Castellana and L. Zdeborová Adversarial satisfiability problem Journal of Statical Mechanics (2011) P03023.

13. M. Castellana and G. Parisi Renormalization group computation of the critical exponents of hierarchical spin glasses Physical Review E 82(4), 040105(R) (2010). 14. M. Castellana, A. Decelle, S. Franz, M. Mézard and G. Parisi Hierarchical random energy model of a spin glass Physical Review Letters 104(12), 127206 (2010). 15. M. Castellana and G. Montani BRST symmetry towards the Gauss constraint for general relativity International Journal of Modern Physics A 23(8), 1218 (2008). Michele Castellana 4

16. M. Castellana and G. Montani Physical state condition in quantum general relativity as a consequence of BRST Symmetry Classical and Quantum Gravity 25(10), 105018 (2008).

Books

1. M. Castellana The renormalization group for disordered systems Sapienza Università Editrice (2014).

Unpublished material

• The BRST symmetry associated to the local Lorentz group for the action of general relativity (thesis of Graduate studies in Theoretical Physics). • The Path Integral in Quantum Mechanics (thesis of Bachelor of Science in Physics).

Conferences attended

Date June 27 - July 5 2013 Title Quantitative Laws of Genome Evolution. Place Centro di Cultura Scientifica A. Volta, Como, Italy. Date June 23 2012 Title Emergent order in Biology. Place Institut d’Études Scientifiques de Cargèse, Cargèse, Corsica, France.

Date November 26 2011 Title Coding, networks and decisions. Place The Graduate Center of the City University of New York, New York, NY, United States.

Date June 14 - 16 2011 Title Physics and biological systems. Place Laboratoire de l’Accélérateur Linéaire (LAL), University Paris Sud, Orsay, France.

Date February 22 - 23 2011 Title Inverse problems and the statistical mechanics of biological networks. Place The Graduate Center of the City University of New York, New York, NY, United States. Michele Castellana 5

Date October 6 - 8 2010 Title Open questions on glasses and glassforming systems. Place Henri Poincaré institute, Paris, France.

Date September 13 - 15 2010 Title Statistical Physics of Complexity, Optimization and Biological Information. Place LPTMS, University Paris Sud, Orsay, France.

Date July 19 - 23 2010 Title StatPhys24. Place Cairns, Queensland, Australia.

Date March 7 - 21 2010 Title Les Houches Physics School: Statistical Physics of Complexity, Optimization and System Biology. Place Les Houches, France.

Date July 6 - 10 2009 Title Congrès Général de la Société Française de Physique (SFP). Place Paris, France.

Date March 10 - 14 2008 Title Statistical Mechanics on Random Structures (EURANDOM). Place Eindhoven, the Netherlands.

Invited talks

Date March 4 2015 Title Enzyme Clustering Can Induce Metabolic Channeling Place American Physical Society (APS) March meeting, Henry B. Gonzalez Convention Center, San Antonio, TX, United States.

Contributed talks

Date December 19 2014 Title Enzyme Clustering Can Induce Metabolic Channeling Place Physics Laboratory, École Normale Supérieure de Lyon, Lyon, France. Date December 16 2013 Title Enzyme Clustering Can Induce Metabolic Channeling Place Department of Mathematics, Università di Bologna, Bologna, Italy. Michele Castellana 6

Date December 5 2013 Title Enzyme Clustering Can Induce Metabolic Channeling Place Laboratoire Charles Coulomb, University Montpellier II, Montpellier, France. Date December 3 2013 Title Enzyme Clustering Can Induce Metabolic Channeling Place Laboratoire de Génomique des Microorganismes, University Pierre et Marie Curie, Paris, France. Date December 2 2013 Title Enzyme Clustering Can Induce Metabolic Channeling Place Collège de France, Paris, France. Date November 29 2013 Title Enzyme Clustering Can Induce Metabolic Channeling Place École Normale Supérieure (ENS) and École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), Paris, France. Date February 15 2013 Title The Renormalization Group for Disordered Systems Place Department of Mathematics, University of Chicago, Chicago, IL, United States. Date April 6 2012 Title The Role of Enzyme Clustering in Metabolic Regulation Place Lewis Thomas Laboratory, Princeton University, Princeton, NJ, United States. Date March 24 2011 Title The Renormalization Group for Disordered Systems Place Laboratoire de Physique Théorique et Hautes Énergies (LPTHE), University Paris 6 and Paris 7, Paris, France. Date February 14 2011 Title Renormalization Group Studies for Disordered Systems Place Max Planck Institute for the Physics of Complex Systems, Dresden, Germany. Date November 29 2010 Title The Renormalization Group for Disordered Systems Place Department of Physics and Astronomy at Rutgers University, Rutgers, NJ, United States. Date November 24 2010 Title The Renormalization Group for Disordered Systems Place Wolynes Group at University of California San Diego, San Diego, CA, United States. Michele Castellana 7

Date November 19 2010 Title The Renormalization Group for Disordered Systems Place Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS), University Paris Sud, Orsay, France. Date July 7 2010 Title The Hierarchical Random Energy Model Place StatPhys24 Conference, Cairns, Queensland, Australia. Date February 2 2010 Title The Adversary Satisfability Problem Place Center for Nonlinear Studies (CNLS) at Los Alamos National Laboratory, Los Alamos, NM, United States. Date May 30 2007 Title The BRST Symmetry Associated to the Local Lorentz Group for the Action of General Relativity Place Physics Department of University La Sapienza, Rome, Italy. Date April 20 2007 Title BRST Symmetry Place Relativistic Astrophysics Center at the Physics Department of University La Sapienza, Rome, Italy.

Other professional experience

Reviewer for Physical Review Letters and Physical Review E. Member of the American Physical Society (APS) and of the American Society for Microbiology (ASM).

Computer skills

C, C++, Parallel Computing (MPI), Mathematica.

References

Name William Bialek Affiliation Joseph Henry Laboratories of Physics and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States. Email address [email protected] Michele Castellana 8

Name Ned Wingreen Affiliation Department of Molecular Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States. Email address [email protected]

Name Giorgio Parisi Affiliation Department of Physics, University La Sapienza, Rome, Italy. Email address [email protected]

Name Marc Mézard Affiliation LPTMS, University Paris Sud, Orsay, France. Email address [email protected]

Name Francesco Guerra Affiliation Department of Physics, University La Sapienza, Rome, Italy. Email address [email protected]

Name Silvio Franz Affiliation LPTMS, University Paris Sud, Orsay, France. Email address [email protected]

Name Federico Ricci-Tersenghi Affiliation Department of Physics, University La Sapienza, Rome, Italy. Email address [email protected]