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In Cooperation with Proficiency Test 8/18 TW S6 – X-Ray- and MRT-Contrast Media in Drinking Water Dear Madam Or Sir, In
Institute for Sanitary Engineering, Water Quality and Solid Waste Management AQS Baden-Württemberg Universit y of Stuttgart ● ISWA ● Bandtäle 2 ● 70569 Stuttgart Contact person AQS Baden-Württemberg Dr. Frank Baumeister, Dr. Michael Koch, Mandy Wünsche To the participants of AQS Baden-Württemberg Contact details Bandtäle 2 70569 Stuttgart GERMANY T +49 711 685-65446 F +49 711 685-63769 [email protected] www.aqsbw.de Proficiency test 8/18 TW S6 – X-ray- and MRT-contrast media in drinking water 2018-06-22 Dear Madam or Sir, in September 2018 the execution of the above mentioned proficiency test (PT) round „X-ray- and MRT-contrast media in drinking water” is planned. The PT is carried out under the umbrella of the NORMAN Network of Reference Laboratories for Monitoring of Emerging Environmental Pollutants (http://www.norman-network.net) in cooperation with IWW Water Centre. Details about the PT round are enclosed. Please read them with care. If you are interested in participation, please register online via our website http://www.iswa.uni-stuttgart.de/ch/aqs/rv/anm_rv.en.php?id=181. You will receive a confirmation of receipt by e-mail. With a second e- mail we will bindingly confirm your application to the PT. You are not registered if you do not receive any e-mail. Application deadline: 24 July 2018 Please consider our general terms and conditions of business for the execution of the PT, which can be downloaded from http://www.aqsbw.de/pdf/agb_en.pdf. Bank Baden-Württembergische If we receive your application after the deadline we cannot guarantee Bank Stuttgart – BW-Bank that participation will be possible. -
Published Version
Chapter 12 Water quality analysis: Detection, fate, and behaviour, of selected trace organic pollutants at managed aquifer recharge sites Mathias Ernst, Arne Hein, Josef Asmin, Martin Krauss, Guido Fink, Juliane Hollender, Thomas Ternes, Claus Jørgensen, Martin Jekel and Christa S. McArdell 12.1 INTRODUCTION In treated municipal wastewater, residual organic compounds are of high relevance especially if water recycling and potable water reuse is envisaged. After biological treatment, such as the activated sludge process, some organic compounds remain that are either non-biodegradable, or are minimally biodegradable. If these chemicals are polar, they are commonly poorly absorbable, and are therefore identified as persistent polar organic compounds (also persistent polar pollutants, PPPs). In the last decade, there have been important analytical improvements in detecting trace levels of pollutants, and within the water reuse community, new “hazardous” compounds are frequently discussed. This includes consideration of which organic residuals are really of health concern, which transformation products can be generated, and what is their human and environmental impact? Within the present chapter relevant PPPs and their fate during (advanced) wastewater treatment and managed aquifer recharge are identified and discussed as results of measuring campaigns at technologically different demonstration sites within the European research project RECLAIM WATER. Such PPPs mainly belong in the group of pharmaceuticals but also industrial chemicals. Here antibiotics such as the macrolides and sulfonamides are of particular concern, because of the eco-toxicological potential of these parent micropollutants, and the potential threat posed by the build-up of antibiotic resistance genes. In addition to known multi-resistant bacteria such as Staphylococci, multi-resistant genes have recently been identified in the intestinal bacteria Citrobacter, Enterobacteriaceae and Escherichia coli (Patoli et al. -
More Than Expectorant: New Scientific Data on Ambroxol in the Context of the Treatment of Bronchopulmonary Diseases
Mini Review iMedPub Journals Journal of Intensive and Critical Care 2017 www.imedpub.com ISSN 2471-8505 Vol. 3 No. 3: 37 DOI: 10.21767/2471-8505.100096 More than Expectorant: New Scientific Data Manuel Plomer1* and 2 on Ambroxol in the Context of the Treatment Justus de Zeeuw of Bronchopulmonary Diseases 1 Medical Affairs CHC Germany, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, D-65926, Frankfurt am Main, Deutschland, German Abstract 2 Medical Specialist for Internal Medicine, Pneumology and Sleep Medicine, Background:Ambroxol has been established for decades in the treatment of Cologne, Germany, German acute and chronic respiratory diseases. A reassessment of the benefit-risk was conducted recently. Objective: What new scientific data, relevant for the treatment of *Corresponding author: bronchopulmonary diseases, were published in the last decade? Dr. Manuel Plomer Method: Systematic literature search via http://www.pubmed.gov with the search term “ambroxol”, covering the publication period from 2006 to 2015. Non- [email protected] relevant publications were excluded manually. Medical Manager, Medical Affairs CHC Results: 64 relevant publications could be identified covering both, clinical and Germany, Sanofi-Aventis Deutschland GmbH, preclinical research. Industriepark Höchst, D-65926 Frankfurt am Conclusion: The traditional indication of ambroxol as an expectorant is confirmed Main, Germany. but new results revealed a better understanding of the various mechanisms of action of ambroxol and the benefits for special patient populations. The Tel: 49 69 305 36803 available data suggest the use of ambroxol as an adjuvant in anti-infective therapy, particularly in case of infections with biofilm-producing pathogens. Lung- protective properties are discussed in both infants and severely ill adult patients. -
European Journal of Scientific Exploration Vol 3 №2 2020
EUROPEAN JOURNAL OF SCIENTIFIC EXPLORATION VOL 3 №2 2020 Determination of Oligomer Content in Benzonatate Drug Substance by HPLC Lakshmi Narasimha Rao Katakam 1 Santhosh Kumar Ettaboina 2 Thirupathi Dongala 2 1Saptalis Pharmaceuticals LLC, New York, USA 2Aurex Pharmaceuticals Inc, East Windsor, USA Abstract. A reverse-phase liquid chromatographic method has developed and validated to determine oligomer content in Benzonatate Drug substances. This method has a separation of relatively few monomer units, which constitutes an oligomer with a minimum adequate chromatographic resolution of 1.0 from each of the subject component peaks. The separation achieved using Phenomenex Luna C18 (250 X 4.6 mm) 5 µm column at a flow rate of 1.0 ml/min with an isocratic elution method. The mobile phase consisting of 0.25% Ammonium formate buffer and methanol in the ratio 350:650 (v/v), respectively. The Oligomer compounds detection carried out at UV 310 nm, and the LC method validated as per the current ICH Q2 guidelines. The method is effectively validated and proved to be precise, specific, linear, robust, and rugged to quantitate oligomer content in Benzonatate drug substance. Key words: benzonatate (BNZ), oligomers, HPLC, method validation. Introduction Benzonatate (BNZ) is an oral antitussive drug used to relieve and suppress cough in patients older than ten years of age (Oligomer Wikipedia, 2020). Currently, BNZ is the only non-narcotic antitussive available as a prescription drug. The chemical structure resembles that of the anesthetic agents in the para-amino-benzoic acid class (such as procaine and tetracaine), BNZ exhibits anesthetic or numbing action. BNZ also inhibits the transmission of impulses of the cough reflex in the medulla's vagal nuclei (Tessalon, 2020). -
Appendix on Tariff Elimination Schedule for Mercosur
Trade part of the EU-Mercosur Association Agreement Without Prejudice Disclaimer: In view of the Commission's transparency policy, the Commission is publishing the texts of the Trade Part of the Agreement following the agreement in principle announced on 28 June 2019. The texts are published for information purposes only and may undergo further modifications including as a result of the process of legal revision. However, in view of the growing public interest in the negotiations, the texts are published at this stage of the negotiations for information purposes. These texts are without prejudice to the final outcome of the agreement between the EU and Mercosur. The texts will be final upon signature. The agreement will become binding on the Parties under international law only after completion by each Party of its internal legal procedures necessary for the entry into force of the Agreement (or its provisional application). AR applied BR applied PY applied UY applied Mercosur Final NCM Description Comments tariff tariff tariff tariff Offer 01012100 Pure-bred horses 0 0 0 0 0 01012900 Lives horses, except pure-bred breeding 2 2 2 2 0 01013000 Asses, pure-bred breeding 4 4 4 4 4 01019000 Asses, except pure-bred breeding 4 4 4 4 4 01022110 Purebred breeding cattle, pregnant or lactating 0 0 0 0 0 01022190 Other pure-bred cattle, for breeding 0 0 0 0 0 01022911 Other bovine animals for breeding,pregnant or lactating 2 2 2 2 0 01022919 Other bovine animals for breeding 2 2 2 2 4 01022990 Other live catlle 2 2 2 2 0 01023110 Pure-bred breeding buffalo, pregnant or lactating 0 0 0 0 0 01023190 Other pure-bred breeding buffalo 0 0 0 0 0 01023911 Other buffalo for breeding, ex. -
Tibolone Has Anti-Inflammatory Effects in Estrogen-Deficient
Regulatory Peptides 179 (2012) 55–60 Contents lists available at SciVerse ScienceDirect Regulatory Peptides journal homepage: www.elsevier.com/locate/regpep Tibolone has anti-inflammatory effects in estrogen-deficient female rats on the natriuretic peptide system and TNF-alpha Ana Raquel Santos de Medeiros a,b, Aline Zandonadi Lamas b, Izabela Facco Caliman b, Polyana L. Meireles Dalpiaz b, Luciana Barbosa Firmes c, Gláucia Rodrigues de Abreu b, Margareth Ribeiro Moysés b, Elenice Moreira Lemos d, Adelina Martha dos Reis c, Nazaré Souza Bissoli b,⁎ a Biological and Health Sciences, Federal Institute of Espírito Santo, Vila Velha, ES, Brazil b Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil c Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil d Center of Infectious Diseases, Federal University of Espírito Santo, Vitória, ES, Brazil article i nfo abstract Article history: Cardiovascular and immune system abnormalities have been reported in females with estrogen deficiency. Received 25 April 2012 To control these disorders in post-menopausal women, hormone replacement therapy (HRT) has been Received in revised form 10 August 2012 used. Tibolone has been used as a HRT, but the effects of tibolone on the natriuretic peptide system have Accepted 29 August 2012 not been determined. We investigated the effects of tibolone on the natriuretic peptide system and Available online 10 September 2012 pro-inflammatory cytokines in ovariectomized (OVX) rats. Female rats were divided into four groups: SHAM, OVX, OVX treated with 17β-estradiol (OVX+E: 14 days) and OVX treated with tibolone (OVX+T: Keywords: Ovariectomy 14 days) beginning 21 days after ovariectomy. -
Flufenamic Acid, Mefenamic Acid and Niflumic Acid Inhibit Single Nonselective Cation Channels in the Rat Exocrine Pancreas
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Volume 268, number 1, 79-82 FEBS 08679 July 1990 Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas H. Gagelein*, D. Dahlem, H.C. Englert** and H.J. Lang** Max-Planck-Institutfir Biophysik, Kennedyallee 70, D-600 Frankfurt/Main 70, FRG Received 17 May 1990 The non-steroidal anti-inflammatory drugs, flufenamic acid, mefenamic acid and niflumic acid, block Ca2+-activated non-selective cation channels in inside-out patches from the basolateral membrane of rat exocrine pancreatic cells. Half-maximal inhibition was about 10 PM for flufenamic acid and mefenamic acid, whereas niflumic acid was less potent (IC,, about 50 PM). Indomethacin, aspirin, diltiazem and ibuprofen (100 /IM) had not effect. It is concluded that the inhibitory effect of flufenamate, mefenamate and niflumate is dependent on the specific structure, consisting of two phenyl rings linked by an amino bridge. Mefenamic acid; Flufenamic acid; Niflumic acid; Indomethacin; Non-selective cation channel; Rat exocrine pancreas 1. INTRODUCTION indomethacin, ibuprofen, diltiazem and acetylsalicylic acid (aspirin) were obtained from Sigma (Munich, FRG). The substances were dissolved in dimethylsulfoxide (DMSO, Merck, Darmstadt, FRG, Recently it was reported that the drug, 3 ’ ,5-dichloro- 0.1% of total volume) before addition to the measuring solution. diphenylamine-2-carboxylic acid (DCDPC), blocks DMSO alone had no effect on the single channel recordings. non-selective cation channels in the basolateral mem- 2.2. Methods brane of rat exocrine pancreatic cells [ 11. -
Synthesis and Pharmacological Evaluation of Fenamate Analogues: 1,3,4-Oxadiazol-2-Ones and 1,3,4- Oxadiazole-2-Thiones
Scientia Pharmaceutica (Sci. Pharm.) 71,331-356 (2003) O Osterreichische Apotheker-Verlagsgesellschaft m. b.H., Wien, Printed in Austria Synthesis and Pharmacological Evaluation of Fenamate Analogues: 1,3,4-Oxadiazol-2-ones and 1,3,4- Oxadiazole-2-thiones Aida A. ~l-~zzoun~'*,Yousreya A ~aklad',Herbert ~artsch~,~afaaA. 2aghary4, Waleed M. lbrahims, Mosaad S. ~oharned~. Pharmaceutical Sciences Dept. (Pharmaceutical Chemistry goup' and Pharmacology group2), National Research Center, Tahrir St. Dokki, Giza, Egypt. 3~nstitutflir Pharmazeutische Chemie, Pharrnazie Zentrum der Universitilt Wien. 4~harmaceuticalChemistry Dept. ,' Organic Chemistry Dept. , Helwan University , Faculty of Pharmacy, Ein Helwan Cairo, Egypt. Abstract A series of fenamate pyridyl or quinolinyl analogues of 1,3,4-oxadiazol-2-ones 5a-d and 6a-r, and 1,3,4-oxadiazole-2-thiones 5e-g and 6s-v, respectively, have been synthesized and evaluated for their analgesic (hot-plate) , antiinflammatory (carrageenin induced rat's paw edema) and ulcerogenic effects as well as plasma prostaglandin E2 (PGE2) level. The highest analgesic activity was achieved with compound 5a (0.5 ,0.6 ,0.7 mrnolkg b.wt.) in respect with mefenamic acid (0.4 mmollkg b.wt.). Compounds 6h, 61 and 5g showed 93, 88 and 84% inhibition, respectively on the carrageenan-induced rat's paw edema at dose level of O.lrnrnol/kg b.wt, compared with 58% inhibition of mefenamic acid (0.2mmoll kg b.wt.). Moreover, the highest inhibitory activity on plasma PGE2 level was displayed also with 6h, 61 and 5g (71, 70,68.5% respectively, 0.lmmolkg b.wt.) compared with indomethacin (60%, 0.01 mmolkg b.wt.) as a reference drug. -
List of Union Reference Dates A
Active substance name (INN) EU DLP BfArM / BAH DLP yearly PSUR 6-month-PSUR yearly PSUR bis DLP (List of Union PSUR Submission Reference Dates and Frequency (List of Union Frequency of Reference Dates and submission of Periodic Frequency of submission of Safety Update Reports, Periodic Safety Update 30 Nov. 2012) Reports, 30 Nov. -
Federal Register/Vol. 75, No. 115/Wednesday, June 16, 2010
34126 Federal Register / Vol. 75, No. 115 / Wednesday, June 16, 2010 / Notices TABLE 2.—REGISTRANTS REQUESTING TABLE 2.—REGISTRANTS REQUESTING the cancellation action. Because the VOLUNTARY CANCELLATION—Con- VOLUNTARY CANCELLATION—Con- Agency has identified no significant tinued tinued potential risk concerns associated with these pesticide products, upon cancellation of the products identified Company Name and EPA Co. Number Company Name and EPA Co. Number Address Address in Table 1 of Unit II., EPA anticipates allowing registrants to sell and AZ970004; Chemtura Corpora- MN940003 Arysta Lifescience distribute existing stocks of these OR030022; tion North America, products for 1 year after publication of LLC WA910017 ATTN: Crop Reg- the Cancellation Order in the Federal istration, Michael 155401 Weston Dupre Parkway, Suite Register. Thereafter, registrants will be 199 Benson Road 150 prohibited from selling or distributing (2-5) Cary, NC 27513 the pesticides identified in Table 1 of Middlebury, CT Unit II., except for export consistent 06749 III. What is the Agency’s Authority for with FIFRA section 17 or for proper Taking this Action? disposal. Persons other than registrants OR910006; FMC Corp., Agricul- will generally be allowed to sell, Section 6(f)(1) of FIFRA provides that CO920001 tural Products distribute, or use existing stocks until a registrant of a pesticide product may Group such stocks are exhausted, provided that ATTN: Michael C. at any time request that any of its such sale, distribution, or use is Zucker pesticide registrations be canceled. consistent with the terms of the 1735 Market St., FIFRA further provides that, before previously approved labeling on, or that RM. -
Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate. -
Product Information Calcium Nitrite 94% Solution
Product Information Calcium Nitrite 94% Solution Product Description: This product is a white powder composed of 94% calcium nitrite. It is a strong oxidising agent and is highly soluble allowing it to promote hydration of minerals in cement and thus its application as an antifreeze additive in cement. Applications: Calcium nitrite is used as a metal corrosion inhibitor for steel in reinforced concrete, antifreeze in cement. It can be used as a heavy oil detergent and in thermal energy storage for air conditioning. Chemical Formula: Ca(NO2)2 CAS No. : 13780-06-8 Specifications: Parameters (units) Specifications Calcium nitrite (%) ≥ 94 Calcium nitrate (%) ≤ 5 Calcium hydroxide (%) ≤ 1.0 Moisture (%) ≤ 1.0 Water insoluble (%) ≤ 1.0 Bisley International LLC 1790 Hughes Landing Boulevard Suite 400 The Woodlands 77380 TX USA Phone number: +1 (844) 424 7539 Emergency telephone number: +1 855 237 5573 bisleyinternational.com Copyright 2021 Bisley & Co. Pty Ltd. All rights reserved Packaging: Packaging options are available upon enquiry. Storage: Product should be stored in a dry place in sealed, original packaging away from direct sunlight. Safety: For further safety information refer to product SDS available from your Bisley International contact. Disclaimer: This document is for information purposes only. Customers are responsible for testing and confirming the suitability of this product in their application. To the extent permitted by law, no warranty as to merchantability or fitness of purpose, expressed or implied, is made. Global Headquarters