McGill University

Department of Microbiology and Immunology

2016 Annual Report

Submitted by

Benoit Cousineau, PhD Associate Professor & Interim Chair On behalf of Primary members of the Department of Microbiology and Immunology

Table of Contents

1. Executive Summary ...... 4 2. Staff List ...... 6 3. Honours, Awards & Prizes ...... 10 4. Publications, Conferences and Patents ...... 12 5. Grants ...... 30 6. Initiatives and Innovations related to Teaching Programs ...... 36 A. Graduate Programs ...... 36 B. Undergraduate Programs ...... 37 7. Success Stories of Faculty and Students ...... 38 8. Departmental Activities ...... 43 9. Academic and Community Service ...... 47 10. Community Involvement (by PI) ...... 48 11. Consulting Activities ...... 64 12. Appendices ...... 65 TABLE 1. NUMBER OF UNDERGRADUATE STUDENTS TAUGHT IN WINTER 2016/ SUMMER 2016/ FALL 2016 ...... 66 TABLE 2. FULL TIME EQUIVALENT (FTE) OF UNDERGRADUATE STUDENTS IN COURSES BY THE DEPT. DURING THE PAST FIVE YEARS ...... 66 TABLE 3. ENROLMENT IN UNDERGRADUATE PROGRAMS IN MICROBIOLOGY & IMMUNOLOGY, WINTER 2016, FALL 2016 ...... 67 TABLE 4. UNDERGRADUATE STUDENTS ENROLLED IN DEPT. DURING THE PAST FIVE YEARS ...... 67 TABLE 5. UNDERGRADUATE ENROLMENT AND COURSE FTE'S - WINTER 2016/SUMMER 2016/FALL 2016 ...... 68 TABLE 6. STUDENT EVALUATION OF UNDERGRADUATE COURSES IN MICROBIOLOGY & IMMUNOLOGY WINTER 2016 AND FALL 2016 ...... 69 TABLE 7. UNDERGRADUATE STUDENTS GRADUATIONS WINTER 2016, SPRING 2016, FALL 2016 .... 69 TABLE 8. UNDERGRADUATES APPLIED/REGISTERED TO THE B.SC./M.SC. FAST TRACK PROGRAM ... 70 TABLE 9. TOTAL GRADUATE DEGREES GRANTED OVER THE PAST FIVE YEARS ...... 70 TABLE 10 . GRADUATE STUDENT ENROLLMENT & POSTDOCS ...... 71 TABLE 11 . GRADUATE STUDENTS & POSTDOCS over the past five years ...... 71 TABLE 12. Funding of graduate students by source (2016) ...... 72

Section I Introduction 1. Executive Summary

2016 was a remarkably successful year for the Department of Microbiology & Immunology.

On September 30th, after a very successful 5-year term as the MIMM Chair, Dr. Joaquin Madrenas decided to take up a new professional challenge by accepting the position of Chief Scientific Officer at LA BioMed. He was replaced by Dr. Hervé LeMoual as the Director of MDTC and Dr. Benoit Cousineau as the MIMM Interim Chair. On August 1st, the MIMM Community welcomed Dr. Jacques Archambault who joined the Department as a Full Professor with tenure. On April 24th, we were all devastated by the sudden passing of one of our Adjunct Member located at the IRCM, Dr. Cheolho Cheong.

Promotions and Awards: Dr. Albert Berghuis was appointed as Chair of the Biochemistry Department at McGill. Dr. Jörg Fritz was promoted to Associate Professor and awarded tenure. Dr. Martin Richer was reappointed as an Assistant Professor for three years. Dr. Nicolas Cermakian was nominated for the Faculty of Medicine Honour list. Dr. Martin Olivier received the R.A. Wardle Medal Career award by the Canadian Society for Zoology. Dr. Ciro Piccirillo received the Anna Maria Solinas Laroche Career Award in Immunology. Dr. Mary Stevenson became a Fellow of the American Society of Tropical Medicine and Hygiene. Dr. Irah King received the New Investigator Award from the Canadian Society for Immunology. Dr. Mark Wainberg received the 2016 AMMI Canada Lifetime Achievement Award, the 2016 D’Arcy McGee Citizenship Medal and was inducted in the Canadian Medical Hall of Fame.

Research: A total of 18 MIMM Primary and Associate Members received funding from CIHR (15) and NSERC (3) in 2016. Dr. Selena Sagan was awarded a Tier 2 Canada Research Chair in RNA Biology and Viral Infections. Dr. Corinne Maurice was awarded a Tier 2 Canada Research Chair in Gut Microbial Physiology and was appointed as an Azrieli Global Scholar by the Canadian Institute For Advanced Research. Dr. Martin Richer received a Chercheur-Boursier Junior 1 Salary Award from FRQS. Dr. Hervé LeMoual and Dr. Irah King both received CFI Infrastructure Operating Funds to help cover a portion of the operating and maintenance costs of CFI-funded equipment. Collectively, our research programs generated 81 publications and attracted over $5.35M in peer- reviewed funding, a 23% increase compared to 2015 ($4.36M). The Department ($20K) and MDTC ($10K) funded again this year two internal grants to support innovative and collaborative research projects.

Education: The MIMM Graduate Program admitted a record number of 30 students who received a total of $127,750 in Graduate Excellence Fellowships. Departmental fellowships, including Graduate Excellence Fellowships, were also awarded to 26 returning graduate students for a total of $100,181. Travel awards for a total of $4,500 were granted to 9 trainees to support the presentation of their work at national and international conferences. In this era of limited academic research funding, it is worth mentioning that 22 MIMM graduate students were financially supported through highly competitive provincial/national/international studentships for a total of $432,678. Notably, Sophie Cousineau (Dr. Selena Sagan’s lab) was awarded a prestigious Vanier Canada Graduate Scholarship. The Graduate and Post-Graduate Education Committee held a town hall meeting to reach out to our graduate student population. The outcome of this town hall will be used to adjust our graduate program during a half-day Faculty Teaching Retreat planned for September 28th, 2017.

In Undergraduate Education, Dr. Claire Trottier, the MIMM educational specialist, with the help of all the MIMM course coordinators, conducted a detailed survey to gather data on all the courses offered by the Department and perform a comprehensive Curriculum mapping. This data was used to identify gaps and determine priorities for discussion at an upcoming half-day Faculty Teaching Retreat planned for September 28th, 2017. In terms of Faculty development, Dr. Trottier organized a workshop specifically for MIMM Faculty in May 2016. This workshop allowed 12 Faculty members to learn about innovative teaching and assessment methods being used by their colleagues. Faculty members gave excellent feedback following this workshop and requested another workshop on assessment. Dr. Trottier then joined a Faculty Development team in the Faculty of Medicine with Dr. David Ragsdale and Dr. Maria Orjuela-Laverde to lead an Assessment Workshop in December 2016. This workshop was attended by MIMM Faculty and Professors from other Departments.

Service and Administration: In conjunction with the Administrative Excellence Center #2 we continued to optimize the administrative and financial operations of the Department. The Department revamped the media core facility by replacing the obsolete autoclave and glassware washing equipment that were too expensive to maintain. These pieces of equipment will be important assets to serve both our educational and research missions for the years to come. In terms of community outreach, we continued to engage with local schools, international Universities and corporate partners.

Finally, I would like to warmly thank and acknowledge the precious help of Dr. Sylvie Fournier (Graduate Education section), Dr. Claire Trottier (Undergraduate Education section), Ms. Suzana Kafadar de Rodriguez, Interim Associate Director of the Administrative Excellence Center #2, and Ms. Lana Kobeici, Senior Administrative Coordinator in preparing this year’s MIMM annual report.

Thank you and all the best,

Benoit Cousineau, PhD 2. Staff List

A. List of Faculty members with primary appointments in the Department

Professors Dr. Jacques Archambault Dr. Albert Berghuis (jointly appointed with Biochemistry) Dr. Joaquin Madrenas (Chair, January to October; on leave since October 01) Dr. Greg Matlashewski Dr. Robert Murgita Dr. Martin Olivier (jointly appointed with Medicine) Dr. Ciriaco Piccirillo Dr. Donald Sheppard (jointly appointed with Medicine) Dr. Mary Stevenson (jointly appointed with Medicine) Dr. Mark Wainberg (jointly appointed with Medicine)

Associate Professors Dr. Dalius Briedis (jointly appointed with Medicine) Dr. Benoit Cousineau (Interim Chair, since October 01) Dr. Sylvie Fournier Dr. Jörg Fritz Dr. Samantha Gruenheid Dr. Herve Le Moual (jointly appointed with Dentistry) Dr. Greg Marczynski

Assistant Professors Dr. Irah King Dr. Connie Krawczyk (jointly appointed with Physiology) Dr. Corinne Maurice Dr. Martin Richer Dr. Selena Sagan

Academic Associate Dr Claire Trottier

B. List of Faculty with secondary appointments

Associate Members Dr. Jack Antel (Department of Neurology, Montreal Neurological Institute) Dr. Amit Bar-Or (Department of Neurology, Montreal Neurological Institute) Dr. Marcel Behr (Division of Infectious Diseases & Medical Microbiology, MUHC) Dr. Miguel Burnier (Department of Ophthalmology, McGill University) Dr. Nicolas Cermakian (Department of Psychiatry, McGill University) Dr. Ines Colmegna (Department of Medicine, Royal Victoria Hospital) Dr. Andre Dascal (Senior Physician, Jewish General Hospital) Dr. Maziar Divangahi (Meakins-Christie Laboratories, McGill University) Dr. Anne Gatignol Dr. Philippe Gros (Rosalind and Morris Goodman Cancer Research Centre) Dr. Sabah Hussain (Critical Care Division, Royal Victoria Hospital) Dr. Armando Jardim (Institute of Parasitology, MacDonald Campus) Dr. Antonis Koromilas (Department of Oncology, Lady Davis Institute for Medical Research) Dr. Arnold Kristof (Critical Care Division, Royal Victoria Hospital) Dr. Chen Liang (Lady Davis Institute for Medical Research) Dr. Rongtuan Lin (Lady Davis Institute for Medical Research) Dr. Vivian Loo (Department of Medicine, Division of Infectious Diseases, MUHC) Dr. Judith Mandl (Department of Physiology) Dr. Andrew Mouland (HIV-1 RNA Trafficking Laboratory, Lady Davis Institute for Medical Research) Dr. Momar Ndao (Department of Medicine, Division of Infectious Disease) Dr. Dao Nguyen (Department of Medicine, Montreal General Hospital Research Institute) Dr. Alexandre Orthwein (Gerald Bronfman Department of Oncology) Dr. Kostas Pantopoulos (Lady Davis Institute, Jewish General Hospital) Dr. Joyce Rauch (Department of Rheumatology, Montreal General Hospital) Dr. Michael Reed (Medicine, Infectious Diseases, Montreal General Hospital) Dr. Petra Rohrbach (Institute of Parasitology, MacDonald Campus) Dr. Maya Saleh (Department of Medicine, McGill Life Science Complex) Dr. Jose Teodoro (Rosalind and Morris Goodman Cancer Research Centre) Dr. Michel Tremblay (Rosalind and Morris Goodman Cancer Research Centre) Dr. Christos Tsoukas (Immune Deficiency Treatment Centre – IDTC, Montreal General Hospital) Dr. Bernard Turcotte (Hormones & Cancer Research Unit, Department of Medicine) Dr. Silvia Vidal (Department of Human Genetics) Dr. Donald Vinh (Department of Medicine) Dr. Brian Ward (Montreal General Hospital) Dr. Jianguo Xia (Institute of Parasitology) Dr. Ji Zhang (Biomedical Sciences, Faculty of Dentistry)

Adjunct Professors Dr. Petronela Ancuta Dr. Cheolho Cheong (Deceased in April 2016) Dr. Albert Descoteaux Dr. Javier Marcelo Di Noia Dr. Andres Finzi Dr. Matthias Gotte Dr. Nathalie Grandvaux Dr. George Kukolj Dr. Peter C. K. Lau Dr. Sylvie Lesage Dr. Shan-Lu Liu Dr. Kelly Anne Pike Dr. Moutih Rafei Dr. Woong-Kyung Suh

Affiliated Members Dr. Catherine Paradis-Bleau Dr. Naglaa Shoukry Mohamed

C. Departmental Non-Academic Staff Jennifer Di Massimo Student Affairs Administrator Monica Toribio Student Affairs Coordinator (absented) Bobbie Carin Student Affairs Coordinator (on assignment) Lana Kobeici Senior Administrative Coordinator Elisa Torres Accounts Administrator (on leave) Shahin Khan Accounts Administrator (on assignment) Aghdas Zhamani Course Coordinator (Teaching Laboratories) Shan Hong Zhang Laboratory Technician (Media Laboratory) Richard Arthur Course Technician (Teaching Laboratories) Tom Ringer Technical Assistant

D. Staff of Departmental-Associated Administrative Excellence Centre Maria Babiak Associate Director, Administration (resigned July) Suzana Kafadar de Rodriguez Associate Director (Interim) (since July) Amy Arnott Human Resources Advisor (on assignment until June) Inna Roo HR and Academic Affairs Officer Tinasha Colquhoun HR Administrator Suzanna Kafadar de Rodriguez Financial Officer (absented) Jackie Krebs Financial Administrator Brenda Ortiz Reyes Senior Accounts Administrator

Section II Research 3. Honours, Awards & Prizes

COUSINEAU, Benoît  MISA Dad Award  Dean of Students – Excellence Academic Advising Award nomination

GRUENHEID, Samantha  MISA Mom Award  Small World Initiative Joe Caruso Award for excellence in mentorship (nominee)  Small World Initiative Support Person of the Year (nominee)  McGill Faculty of Science Leo Yaffe Award for Excellence in teaching 2016 ALTISE Best Practices and Pedagogical Innovators Award (nominee)

KING, Irah  MIMM Primary Teaching Award, Awarded April 8, 2016  2016 Canadian Society of Immunology New Investigator Award

OLIVIER, Martin  R.A. Wardle Medal Award (CSZ 2016). Award from the Canadian Society for Zoology in recognition to Canadian-based research for outstanding contributions in Immunology and Parasitology during his career. Lecture in May 2016.

PICCIRILLO, Ciriaco  Anna Maria Solinas Laroche Career Award in Immunology

RICHER, Martin  CIHR New Investigator Salary Award 2016-2022  FRQS Chercheurs-Boursier Junior 1 2016-2020

SAGAN, Selena, M.  CRC Tier II in RNA biology and Viral infections ($100K/yr x 5 years, Jul 2016 – Jun 2021)

SHEPPARD, Don  FRSQ Chercheur Boursier Senior, 2012-2016

STEVENSON, Mary  Fellow of the American Society of Tropical Medicine and Hygiene. Nov 2016

WAINBERG, Mark  2016 Laureat inducted in April 2016 Canadian Medical Hall of Fame  2016 Lifetime Achievement Award (awarded in 2016) AMMI (Assoc. of Med Micro and Inf. Diseases– Canada)  2016 D’Arcy McGee Citizenship Medal By David Birnbaum, Member of Quebec National Assembly Department of Microbiology and Immunology: 2016 Annual Report

4. Publications, Conferences and Patents

ARCHAMBAULT, Jacques

Publications:

Grubman, S. A., Shin, J., Phelan, P. J., Gong, A., Can, H., Dilworth, R., Kini, S. K., Gagnon, D., Archambault, J., Meinke, G., Bohm, A., Jefferson, D. M. and Bullock, P. A. (2016). Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T-antigen. Virology; 497:92-101. doi: 10.1016/j.virol.2016.07.006.

Bergvall, M., Gagnon, D., Titolo, S., Lehoux, M., D'Abramo, C. M., Melendy, T. and Archambault, J. (2016) Requirement for the E1 Helicase C-terminal domain in papillomavirus DNA replication in vivo. J. Virol.; 90(6):3198-3211. doi: 10.1128/JVI.03127-15.

Meinke, G., Phelan, .P. J., Shin, J., Gagnon, D., Archambault, J., Bohm, A., Bullock, P. A. (2016). Structural based analyses of the JC virus T-antigen F258L mutant provides evidence for DNA dependent conformational changes in the C-termini of polyomavirus origin binding domains. PLoS Pathog.; 12(1):e1005362. doi: 10.1371/journal.ppat.1005482.

El-Hachem, N., Grossmann, P., Blanchet-Cohen, A., Bateman, A. R., Bouchard, N., Archambault, J., Aerts, H. J., Haibe-Kains, B. (2016). Characterization of conserved toxicogenomic responses in chemically exposed hepatocytes across species and platforms. Environ Health Perspect.; 124(3):313-320. doi: 10.1289/ehp.1409157.

Conferences:

Homiski, C., J. Fisk, J. Archambault and T. Melendy. 2016. Characterization of DNA replication functions of SV40 Large T antigen with a phospho-dominant mutation at a DDR kinase site. 20th Annual Buffalo DNA Replication and Repair Symposium, Amherst/Getzville, NY, USA (May 5-6). Oral presentation.

Amanda, P., D. Gagnon, M. Bergvall, J. Archambault and T. Melendy. 2016. Mutational analysis of the highly-conserved critical C-terminus of the papillomavirus E1 DNA helicase domain. 20th Annual Buffalo DNA Replication and Repair Symposium, Amherst/Getzville, NY, USA (May 5-6). Poster presentation.

Homiski, C., J. Fisk, J. Archambault and T. Melendy. 2016. Characterization of DNA replication functions of SV40 Large T antigen with a phospho-dominant mutation at a DDR kinase site. Montreal DNA Tumour Virus Meeting, Montreal, Canada (July 21-26). Oral presentation

Amanda, P., D. Gagnon, M. Bergvall, J. Archambault and T. Melendy. 2016. Mutational analysis of the highly-conserved critical C-terminus of the papillomavirus E1 DNA helicase domain. Montreal DNA Tumour Virus Meeting, Montreal, Canada (July 21-26). Oral presentation. Department of Microbiology and Immunology: 2016 Annual Report

Pinard, M., N. Sriskandarajah, C. Spickler, C. M. D’Abramo, D. Gagnon and J. Archambault. 2016. Nuclear accumulation of the human papillomavirus E1 helicase is linked to cell cycle commitment and is affect by the mevalonate pathway. Montreal DNA Tumour Virus Meeting, Montreal, Canada (July 21-26). Poster presentation.

Sriskandarajah, S., A. Gomez, D. Gagnon, S. Titolo and J. Archambault. 2016. An Hsc70-binding peptide derived from SV40 Large T antigen is a potent inhibitor of polyomavirus DNA replication. Montreal DNA Tumour Virus Meeting, Montreal, Canada (July 21-26). Poster presentation.

Alvarez, J., D. Gagnon, F. Coutlée and J. Archambault. 2016. Modulation of the Human Papillomavirus Type 33 Long Control Region by Two Regulatory Binding Sites for the Cellular Transcription Factor C/EBPβ. Montreal DNA Tumour Virus Meeting, Montreal, Canada (July 21-26). Oral presentation.

Nuclear accumulation of the HPV E1 helicase is tied to cell cycle progression and mitogenic signaling, University of Tartu, Tartu, Estonia (Jan 20, 2016)

Let’s talk science, together with Dr. Selena Sagan, October 26 (30 min presentation each followed by discussion)

COUSINEAU, Benoit

Publications:

Schwartz JS, Peres AG, Mfuna Endam L, Cousineau B, Madrenas J, Desrosiers M. Topical probiotics as a therapeutic alternative for chronic rhinosinusitis: A preclinical proof of concept. Am J Rhinol Allergy. 2016 Nov 1;30(6):202-205. doi: 10.2500/ajra.2016.30.4372. PMID: 28124641, Select item 27765015 [ ]2.

LaRoche-Johnston F, Monat C, Cousineau B. Recent horizontal transfer, functional adaptation and dissemination of a bacterial group II intron. BMC Evol Biol. 2016 Oct 20;16(1):223. PMID: 27765015

Monat C, Cousineau B. Circularization pathway of a bacterial group II intron. Nucleic Acids Res. 2016 Feb 29;44(4):1845-53. doi: 10.1093/nar/gkv1381. PMID: 26673697

Conferences:

Cousineau B. Circularization pathways of a bacterial group II intron. Département de Biochimie, Université de Sherbrooke, Qc, Canada (Nov 29th, 2016). Seminar.

LaRoche-Johnston F, Monat C and Cousineau B. (2016). Recent horizontal transfer of a bacterial group II intron: functional adaptation and evolutionary relationship between Ll.LtrB and Ef.PcfG. RiboClub 17th Annual Meeting, Orford, Canada (Poster Presentation).

LaRoche-Johnston F, Monat C, Coulombe S and Cousineau B. (2016). Capture of mRNA fragments at the splice junction of group II intron RNA circles. RiboClub 17th Annual Meeting, Orford, Canada (Poster Presentation). Department of Microbiology and Immunology: 2016 Annual Report

LaRoche-Johnston F, Monat C, Coulombe S and Cousineau B. (2016). Capture of mRNA fragments at the splice junction of group II intron RNA circles. CBGRC 19th Annual Meeting, Concordia University, Montreal, Canada (Poster Presentation).

LaRoche-Johnston F, Monat C and Cousineau, B. (2016). Recent Horizontal transfer of a bacterial group II intron: Evolutionary Relationship and functional adaptation between Ll.LtrB and Ef.PcfG. McGill Department of Microbiology And Immunology 5th Annual Graduate Student Research Day. Montreal, Canada. (Oral Presentation).

FOURNIER, Sylvie

Publication:

Kassa FA, Van Den Ham K, Rainone A, Fournier S, Boilard E, Olivier M. Absence of apolipoprotein E protects mice from cerebral malaria. Sci Rep. 2016 Sep 20;6:33615. doi: 10.1038/srep33615.

FRITZ, Jörg

Publications:

Daugan M., Murira A., Mindt B.C., Germain A., Tarrab E., Lapierre P., Fritz J.H., Lamarre A. Type I Interferon Impais Specific Antibody Responses Early during Establishment of LCMV infection. (2016) Frontiers in Immunology, 7:564. DOI: 10.3389/fimmu.2016.00564

Förster M., Farrington K., Petrov J.C., Belle J.I., Mindt B.C., Witalis M., Duerr C.U., Fritz J.H., Nijnik A. (2016). MYSM1-dependent checkpoints in B cell lineage differentiation. Journal of Leukocyte Biology, 101(3):643-654. DOI: 10.1189/jlb.1AB0415-177RR

Liu Y., Goulet M.L., Sze A., Hadj S.B., Belgnaoui S.M., Lababidi R.R., Zheng C., Fritz J.H., Olagnier D., Lin R. (2016). RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection. Journal of Virology 90(20):9406-19. DOI: 10.1128/JVI.00748-16

Sila-Barrios S., Smans M., Duerr C.U., Qureshi S.T., Fritz J.H., Descoteaux A., Stager S. (2016) Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia. Cell Reports, 15(11):2427-37. DOI: 10.1016/j.celrep.2016.05.028

Duerr C.U., Fritz J.H. (2016). Cytokine-mediated regulation of group 2 innate lymphoid cells. Cytokine, 87:1-8. DOI: 10.1016/j.cyto.2016.01.018

Yun T.J., Lee J.S., Machmach K., Shim D., Choi J., Wi Y.J., Jang H.S., Jung I.H., Kim K., Yoon W.K., Miah M.A., Li B., Chang J., Ebgo M.G., Pham T.N., Loschko J., Fritz J.H., Krug A.B., Lee S.P., Keler T., Guimond J.V., Haddad E., Cohen E.A., Sirois M.G., El-Hamamsy I., Colonna M., Oh G.T., Choi J.H., Cheong C. (2016). Indoleamine 2,3-Dioygenase-expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Cell Metabolism, 23(5):852-66. DOI: 10.1016/j.cmet.2016.04.010 Department of Microbiology and Immunology: 2016 Annual Report

Duerr C.U., McCarthy C.D.A., Mindt B.C., Rubio M., Meli A.P., Pothlichet J., Eva M.M., Gauchat J.F., Qureshi S.T., Mazer B.D., Mossman K.L., Malo D., Gamero A.M., Vidal S.M., King I.L., Sarfati M., Fritz J.H. (2016). Type I interferon restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. Nature Immunology, 17(1):65-75. DOI: 10.1038/ni.3308

Conferences:

Canadian Society of Immunology Meeting, Ottawa, April 2016:

- Mindt B.C.*, Duerr C.U., Fritz J.H. “Role of Type III Interferons in the Regulation of B cell immunity”. (Poster Presentation, *= presenting author) - McCarthy C.D.A.*, Duerr C.U., Mindt B.C., Fritz J.H. “Establishing a Method for the in vitro expnsion of murine group 2 innate lymphoid cells”. (Poster Presentation, *= presenting author). - Duerr C.U.*, McCarthy C.D.A., Mindt B.C., Fritz J.H. “Regulation of group 2 innate lymphoid cells y type I interferon”. (Poster Presentation, *= presenting author)

CIACCO Meeting, Sherbrooke, May 2016:

- Mindt B.C.*, Duerr C.U., Fritz J.H. “Role of Type III Interferons in the Regulation of B cell immunity”. (Poster Presentation, *= presenting author) - McCarthy C.D.A.*, Duerr C.U., Mindt B.C., Fritz J.H. “Establishing a Method for the in vitro expnsion of murine group 2 innate lymphoid cells”. (Poster Presentation, *= presenting author). - Duerr C.U.*, McCarthy C.D.A., Mindt B.C., Fritz J.H. “Regulation of group 2 innate lymphoid cells y type I interferon”. (Poster Presentation, *= presenting author)

EMBO Conference, Innate Lymphoid Cells, Berlin, December 2016

- McCarthy C.D.A.*, Duerr C.U., Mindt B.C., Fritz J.H. “Establishing a Method for the in vitro expnsion of murine group 2 innate lymphoid cells”. (Poster Presentation, *= presenting author). - Duerr C.U.*, McCarthy C.D.A., Mindt B.C., Fritz J.H. “Regulation of group 2 innate lymphoid cells y type I interferon”. (Poster Presentation, *= presenting author)

Seminars:

MUHC – Meakins Christie Laboratories Seminar Series, 26th September 2016: Type I IFN restricts type 2 immunopathology through regulation of group 2 Innate lymphoid cells. (invited by Dr. Caroline Baglole).

McMaster&University – Farncombe Institute, 9th November 2016: Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. (invited by Dr. Elena Verdu)

MRCCT Symposium, 28th November 2016: Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. (invited by Dr. Silvia Vidal).

EMBO Conference – Innate Lymphoid Cells, Berlin Germany, 30th November 2016: Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. (invited by Dr. Chiara Romagnani). Department of Microbiology and Immunology: 2016 Annual Report

CETI – Inauguration Symposium, MUHC, Montreal, 16th December 2016: Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. (invited by Dr. Ciro Piccirillo).

GRUENHEID, Samantha

Publication:

Kang, E., Yousefi, M., and Gruenheid, S. (2016). R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice. PLoS One; 2016 Apr 5;11(4):e0152859. doi: 10.1371/journal.pone.0152859.

Conferences:

12th Annual Bellairs research Workshop: Cell Biology of Disease, Folkestone, Barbados 2016. R-spondin 2: tipping the balance from homeostasis to dysfunction during intestinal infection. Invited Speaker.

KING, Irah

Publications:

Meli AP, Fontés G, Avery DT, Leddon SA, Tam M, Elliot M, Ballesteros-Tato A, Miller J, Stevenson MM, Fowell DJ, Tangye SG, King IL.The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance. Immunity. 2016 Oct 18;45(4):831-846. doi: 10.1016/j.immuni.2016.09.018.

Duerr CU, McCarthy CD, Mindt BC, Rubio M, Meli AP, Pothlichet J, Eva MM, Gauchat JF, Qureshi ST, Mazer BD, Mossman KL, Malo D, Gamero AM, Vidal SM, King IL, Sarfati M, Fritz JH. Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nat Immunol. 2016 Jan;17(1):65-75. doi: 10.1038/ni.3308.

Conferences:

Cell Press Symposium: “100 years of Phagocytes”, Giardini Naxos, Sicily, Ital. Poster Presentation, September 19 – 22, 2016.

University of Toronto, Department of Immunology Seminar Series: “CD4 + T cell lineage decision making during intestinal parasite infection”; Invited speaker, January 25th, 2016

University of Montreal, CR‐CHUM Seminar Series: “Regulating the IL‐23/IL‐17 skin immune axis”; Invited speaker, April 19th, 2016

Laval University, Centre Hospitalier de l'Université Laval Seminar Series: “Regulating the IL‐ 23/IL-17 skin immune axis”; Invited speaker, December 8th, 2016.

Department of Microbiology and Immunology: 2016 Annual Report

KRAWCZYK, Connie

Publications:

Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu H-HC, Everts B, Pearce EJ, Lupien M, White JH, and CM Krawczyk. (2016) The transcriptional repressor Polycomb group factor 6, PCGF6, negatively regulates dendritic cell activation and promotes quiescence. Cell Reports. 16, 1829-37

Torre, S, Polyak, MJ, Langlais, D, Fodil, N, Kennedy,JM, Radovanovic, I, Berghout, J, Leiva-Torres, G, Krawczyk, CM, Ilangumaran, S, Karen Mossman, K, Liang, C, Klaus-Peter Knobeloch, K-P, Luke M. Healy, LM, Antel, J, Arbour, N, Pratt, A, Majewski, J, Lathrop, M, Vidal, SM and P. Gros. (2016) USP15 regulates type I interferon response in vivo and is required for pathogenesis of microbial and autoimmune neuroinflammation. Nature Immunology. Nov 16;17(12):147

Boudreau JE, Wouters MC, and CM Krawczyk. 8th Annual Canadian Cancer Immunotherapy Consortium (CCIC) Symposium 2015--May 20-22, Vancouver, Canada. Cancer Immunol Immunother. 2016 Feb;65(2):235-41.

Conferences:

8th Annual Ontario-Quebec Undergraduate Immunology Conference. Acquisition of Cellular Phenotype: cell identity, effector function and career decisions. Keynote Address.

DC2016 14th International Symposium on Dendritic Cells “The transcriptional regulators PCGF6 and JARID1c negatively regulate dendritic cell activation and promote quiescence. Invited Speaker (International)

Lady Davis Seminar Series “Restraining DC Activation by PCGF6 and JARID1c”. Presentation.

McGill-Weizmann Symposium “Restraining DC activation”. Presentation

LE MOUAL, Hervé

Publication:

Le Moual, H. (2016) Microbiota-derived metabolites modulate tissue homeostasis: relevance to the oral cavity. Oral Diseases 22(5), 350-352.doi: 10.1111/odi.12477

Conferences:

Le Moual, H. Bacterial outer-membrane proteases of the omptin family as novel therapeutic targets. 14th Annual Congress of International Drug Discovery Science and Technology (IDDST), South Korea, June 18, 2016. (Invited speaker and session chair). Department of Microbiology and Immunology: 2016 Annual Report

Giannakopoulou, N., Thomassin, J-L., Zhu L., Le Moual H. and Gruenheid S. Twocomponent systems and altered virulence of Citrobacter rodentium. The 66th Annual Conference of the Canadian Society of Microbiologists, University of Toronto, Toronto, Ontario, June 2016. Poster presentation.

Giannakopoulou, N.*, Thomassin, J-L., Zhu L., Le Moual H. and Gruenheid S. Two component systems and altered virulence of Citrobacter rodentium. McGill University Research Centre on Complex Traits Symposium, November 2016. Poster presentation. *Award for best poster (Ph.D. Student).

MADRENAS, Joaquin

Publications:

Levast B, Barblu L, Coutu M, Prévost J, Brassard N, Peres A, Stegen C, Madrenas J, Kaufmann DE, Finzi A. HIV-1 gp120 envelope glycoprotein determinants for cytokine burst in human monocytes. PLoS One. 2017; 12(3):e0174550.

Schwartz JS, Al-Mot S, Endam MF, Al-Romaih S, Madrenas J, Desrosiers M. . Rhinology. 2017; doi: 10.4193/Rhin16.199.

Li Z, Levast B, Madrenas J. Staphylococcus aureus Downregulates IP-10 Production and Prevents Th1 Cell Recruitment. J Immunol. 2017; 198(5):1865-1874.

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T. The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 2016; 17(12):1844-1856.

Schwartz JS, Peres AG, Mfuna Endam L, Cousineau B, Madrenas J, Desrosiers M. Topical probiotics as a therapeutic alternative for chronic rhinosinusitis: A preclinical proof of concept. Am J Rhinol Allergy. 2016; 30(6):202-205.

MATLASHEWSKI, Greg

Publications:

Das VN, Pandey RN, Siddiqui N, Chapman L, Kumar V, Matlashewski G*, Das P* (2016) Longitudinal study of transmission in households with visceral leishmaniasis, asymptomatic infections and PKDL in highly endemic villages in Bihar, India. PLoS-NTD Dec 14 10(12) e0005196.

Mondal D, Ghosh P, Khan MA, Hossain F, Böhlken-Fascher S, Matlashewski G, Kroeger A, Olliaro P, Abd El Wahed A. (2016) Mobile suitcase laboratory for rapid detection of Leishmania donovani using recombinase polymerase amplification assay. Parasit Vectors, 9:281-293.

Mondal D, Hasnain MG, Hossain MS, Ghosh D, Ghosh P, Hossain H, Baker J, Nath R, Haque R, Matlashewski G, Hamano S. (2016) Study on the safety and efficacy of miltefosine for the treatment of children and adolescents with post-kala-azar dermal leishmaniasis in Bangladesh: an open clinical trial and case-control Department of Microbiology and Immunology: 2016 Annual Report study protocol. BMJ Open. 17; 6(5):e010050.

Das VNR, Pandey RN, Kumar V, Pandey K, Siddiqui NA, Verma RB, Matlashewski G*, Das P*. Repeated training of accredited social health activists (ASHAs) for improved detection of visceral leishmaniasis cases in Bihar, India. (2016) Pathogens and Global Health 110(1): 33-35.

*co-corresponding authors

Conferences:

WHO advisory meeting on elimination of visceral leishmaniasis. Kathmandu, Nepal, March 30, 2016. Chairperson and invited speaker.

American Society of Tropical Medicine and Hygiene. Atlanta, USA, November 15, 2016. The use of CRISPR- Cas in Leishmania to develop live attenuated vaccine strains. Invited speaker.

Gennova Pharmaceuticals. Pune, India, December 8, 2016. The use of CRISPR-Cas in Leishmania to develop live attenuated vaccine strains. Invited speaker.

Infectuous Diseases in Global Health group, MUHC-McGill, November 3, 2016. Elimination of visceral leishmaniasis through basic and implementation research.

MAURICE, Corinne

Publications:

Bokulich NA, Rideout JR, Mercurio WG, Shiffer A, Wolfe B, Maurice CF, Dutton RJ, Turnbaugh PJ, Knight R, Caporaso JG. (2016) mockrobiota: a public resourcefor microbiome bioinformatics benchmarking. mSystems; 1(5). pii: e00062-16.

Taguer M and Maurice CF. (2016) The complex interplay of diet, xenobiotics, and microbial metabolism in the gut: implications for clinical outcomes. Clin Pharmacol Ther.; 99(6): 588-599. doi: 10.1002/cpt.366.

Conferences:

The active gut microbiota and its phage regulators. CIFAR Humans & Microbiome Program, Portland, USA. November 2016. Invited speaker.

The human gut: a complex microbial ecosystem. Research Day, Université Laval, Quebec, Canada. May 1, 2016. Presentation.

Exploring bacterial physiology in the human gut. Faculté de Médecine Vétérinaire, Université de Montreal, Montreal, Canada. February 2, 2016. Presentation. Department of Microbiology and Immunology: 2016 Annual Report

MURGITA, Robert

Conference:

Eweek of the Dawson College, November 17, 2016. “Protecting your invention: A Discussion of Patents and Trade Secrets”. Invited speaker.

OILIVIER, Martin

Publications:

P.A. Casgrain, C. Martel, W.R. McMaster, J. Mottram, M. Olivier and A. Descoteaux. Cysteine protease B regulates Leishmania mexicana virulence through the modulation of GP63 expression. PLoS Pathogens DOI:10.1371/journal.ppat.1005658 May 18 (2016).

V.D. Atayde, K. Hassani, A. da Silva Lira Filho, A. Raposo Borges, A. Adhikari, C. Martel and M. Olivier. Leishmania Exosomes and other Virulence Factors : Impact on Innate Immune Response and Macrophage Functions. Cellular Immunology S0008-8749(16)30062-4. 10.1016/j.cellimm.2016.07.013 (2016).

F.A. Kassa, K. Van Den Ham, A. Rainone, S. Fournier, É. Boilard and M. Olivier. Absence of Apolipoprotein E Protects Mice from Cerebral Malaria. Nature Scientific Reports 6, 33615; doi: 10.1038/srep33615 (2016).

PICCIRILLO, Ciriaco

Publications:

Istomine R, Pavey N, Piccirillo CA. Posttranscriptional and Translational Control of Gene Regulation in CD4+ T Cell Subsets. J Immunol. 2016 Jan 15;196(2):533-40. doi: 10.4049/jimmunol.1501337.

Pesenacker AM, Wang AY, Singh A, Gillies J, Kim YW, Piccirillo CA, Nguyen D, Haining WN, Tebbutt SJ, Panagiotopoulos C, Levings MK. A Treg gene signature is a specific and sensitive biomarker to identify children with new onset type 1 diabetes. (Diabetes 2016)

Bin Dhuban K, Piccirillo CA. The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Curr Opin Allergy Clin Immunol. Dec;15(6): 525-32. doi: 10.1097/ACI.0000000000000214. (online 2016)

Conferences:

Canadian Society of Immunology (CSI) Symposium at FOCIS 2016, Immunophenotyping to understand mechanisms in human disease (Chair)

2016 Canadian Human Immunophenotyping Symposium (Chair) Department of Microbiology and Immunology: 2016 Annual Report

2016 FOCIS Centres of Excellence meeting, invited speaker

Seminars:

Scripps Research Institiute/Janssen Pharmaceuticals Invited speaker, Functional dynamics of human regulatory T cells. Janssen Pharmaceuticals, (La Jolla, USA 2016)

Canadian Society of Immunology (CSI) Symposium at FOCIS 2016 (Boston), Immunophenotyping to understand mechanisms in human disease (Speaker), Molecular and functional dissection of inheritable mutations in the human FOXP3 gene: implications for therapy.”

University of Manitoba Flow Cytometry Symposium Monitoring the dynamics of human FOXP3+ regulatory T cells in health and disease. (Winnipeg, September 2016)

University of Manitoba Department of Immunology, Monitoring the dynamics of human FOXP3+ regulatory T cells in health and disease. (Winnipeg, September 2016)

Italian Society of Immunology and NRC, Molecular and functional dissection of inheritable mutations in the human FOXP3 gene: implications for therapy. (Naples, Italy, October 2016)

VIB-KU Leuven Center for Brain & Disease Research, Translational Immunology Group, Molecular and functional dissection of inheritable mutations in the human FOXP3 gene: implications for therapy. (Leuven, Belgium, October 2016)

IRCM Distinguished Seminar series (Montreal, December 2016) Molecular and functional dissection of inheritable mutations in the human FOXP3 gene: implications for therapy.

Functional dynamics of human regulatory T cells, IDIGH Program seminar series, RIMUHC Seminar Series (Montreal, December 2016)

RICHER, Martin

Publications:

Rajah MM, Pardy RP, Condotta SA, Richer MJ# and Sagan SM# (2016) Zika Virus: Emergence, Phylogenetics, Challenges and Opportunities. ACS Infectious Disease Oct 5;2(11):763-772. PMID: 27704772 #=co- corresponding authors

Richer MJ*#, Lang ML and Butler NS*# (2016) T cell fates ‘zipped up’: how the Bach2 basine leucine zipper transcriptional repressor directs T cell differentiation and function. Journal of Immunology Aug 15;197(4):1009-15. PMID: 27496973 *=authors contributed equally #=co-corresponding authors

Vacaflores A, Chapman NM, Harty JT, Richer MJ and Houtman JC (2016). Exposure to IL-12 results in enhanced TCR-induced cytokine production, altered TCR signaling, and increased oxidative metabolism. PLOS ONE. June 9; 11(6): e0157175. PMID: 27280403 Department of Microbiology and Immunology: 2016 Annual Report

Conferences:

University of Alberta, Edmonton, AB. December 1st 2016. The not so sweet side of immunoregulation: chronic inflammation dampens host immunity by targeting CD8 T cell antigen sensitivity. (Invited Speaker)

McGill University, Goodman Cancer Research Centre, Montreal, QC. November 16th 2016. The not so sweet side of immunoregulation: chronic inflammation dampens host immunity by targeting CD8 T cell antigen sensitivity. (Invited Speaker)

University of Texas Health Science Center at San Antonio, San Antonio, TX. Department of Microbiology, Immunology & Molecular Genetics. September 8th 2016. A novel role for cyclophilin D in antiviral immune responses. (Invited Speaker)

SAGAN, Selena M.

Publications:

Pardy RD, Rajah MM, Condotta SA, Taylor NG, Sagan SM and Richer MJ. Zika Virus induces a robust immune response in wild-type immunocompetent mice. (2017) PLoS Path. 13(2): e1006184.

Rajah MM, Pardy RD, Condotta SA, Richer MJ and Sagan SM. Zika virus: Emergence, Phylogenetics, Challenges and Opportunities. (2016) ACS Infect Dis. 2(11):763-772. van Buuren N, Fradette L, Grebely J, King A, Krajden M, MacParland SA, Marshall A, Saeed S, Wilson JA, Klein MB, Sagan SM. The 5th Canadian Symposium on Hepatitis C virus: We’re Not Done Yet: Remaining Challenges in Hepatitis C. (2016) Can J Gastroenterol Hepatol. 60(4):2018-2027.

Sarnow P and Sagan SM. Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver- specific MicroRNA miR-122. Annual Review of Virology (2016) 3(1):309-332.

Izreig S, Samborska B, Johnson RM, Sergushichev A, Ma EH, Lussier C, Loginicheva E, Donayo AO, Poffenberger MC, Sagan SM, Vincent EE, Artyomov MN, Duchaine TF, Jones RG. The miR-17~92 microRNA Cluster is a Global Regulator of Tumor Metabolism. (2016) Cell Reports 16(7):1915-1928.

Sagan SM, Dupont B, Grebely J, Krajden M, MacParland S, Raven JF, Saeed S, Feld JJ, Tyrrell DL, and Wilson JA. Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving Towards a National Action Plan. Can J Gastroenterol Hepatol. (2016) 2016:5743521, 11 pages.

Kulkarni AS, Damha MJ, Schinazi RF, Mo H, Doehle B, Sagan SM, and Götte M. A complex network of Interactions between S282 and G283 of Heaptitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin. Antimicrob Agent Chemother (2016) 60 (4): 2018- 2027.

Department of Microbiology and Immunology: 2016 Annual Report

Conferences:

Annie Bernier, Selena M. Sagan. RNA Pull-down Strategies to Investigate the Roles of MicroRNA-122- Associated Complexes in Hepatitis C Virus Infection. Poster presentation, 5th Canadian Symposium on HCV, February 26, 2016, Montreal, Qc, Canada

Jasmin Chahal and Selena M. Sagan. Live Cell SHAPE to Investigate the Structure of HCV RNA. Poster presentation, 5th Canadian Symposium on Hepatitis C Virus, Montreal, QC, Feb 26th, 2016

Sophie Cousineau & Selena M Sagan. Dissecting the role of the poly(rC)-binding protein 2 in the hepatitis C virus life cycle. Poster presentation, 5th Canadian Symposium on Hepatitis C Virus, Montreal, QC, Feb 26th, 2016

Mike Rajah & Selena M. Sagan. Interrogating the Structure of the Dengue Virus (DENV) RNA using SHAPE Analysis. Poster presentation, 5th Canadian Symposium on Hepatitis C Virus, Montreal, QC, Feb 26th, 2016

Annie Bernier, Selena M. Sagan. RNA Pull-down Strategies to Investigate the Roles of MicroRNA-122- Associated Complexes in Hepatitis C Virus Infection. Poster presentation, Canadian Association for the Study of the Liver (CASL), February 27, 2016, Montreal, Qc, Canada

Annie Bernier, Selena M. Sagan. RNA Pull-down Strategy to Investigate the Roles of MicroRNA-122- Associated Complexes in Hepatitis C Virus Infection. Poster presentation, Graduate student research day, McGill University, May 20, 2016, Montreal, Qc, Canada

Sophie Cousineau & Selena M Sagan. Dissecting the role of the poly(rC)-binding protein 2 in the hepatitis C virus life cycle. Poster presentation, Microbiology & Immunology Graduate Research Day, Montreal, QC, May 20th, 2016

Mike Rajah & Selena M. Sagan. Using Live cell SHAPE Analysis to Compare the Structure of Dengue virus (DENV) RNA in Human and Mosquito cells. Poster presentation, Microbiology & Immunology Graduate Research Day, Montreal, QC, May 20th, 2016

Annie Bernier, Selena M. Sagan. RNA Pull-down Strategy to Investigate the Roles of MicroRNA-122- Associated Complexes in Hepatitis C Virus Infection. Oral presentation, RiboClub Annual Meeting, September 19, 2016, Orford, Qc, Canada

Sophie Cousineau & Selena M Sagan. Dissecting the role of the poly(rC)-binding protein 2 in the hepatitis C virus life cycle. Poster presentation, Annual RiboClub Meeting, Orford, QC, Sep 19-20th, 2016

Jasmin Chahal and Selena M. Sagan. Investigating RNA secondary structural alterations of the HCV genome mediated by miR-122. Oral presentation. RiboClub Annual Meeting. Orford, QC, Sep 19-20th, 2016 Department of Microbiology and Immunology: 2016 Annual Report

Mike Rajah and Selena M. Sagan. Live cell SHAPE Analysis to Interrogate the Dengue and Zika Virus RNA structures in Mosquito and Human cells. Poster presentation. RiboClub Annual Meeting. Orford, QC, Sep 19-20th, 2016

NCRTP-HepC Seminar Series, 2015-2016, How to get a Good Postdoctoral position, Jan 13th, 2016

SHEPPARD, Donald

Publications:

Baistrocchi SR, Lee MJ, Lehoux M, Ralph B, Snarr BD, Robitaille R, Sheppard DC*. (2016) Posaconazole- loaded leukocytes as a novel treatment strategy targeting invasive pulmonary aspergillosis. Journal of Infectious Diseases. Epub Oct 31.

Liu H, Lee MJ, Solis NV, Phan QT, Swidergall M, Ralph B, Ibrahim AS, Sheppard DC*, and Filler SG*. (2016) CalA binds to integrin α5β1 and mediates host cell invasion during Aspergillosis. Nature Microbiology, Nov; 2:16211

Baker P., Hill PJ., Snarr BD., Alnabelseya N., Pestrak JM, Lee MJ., Jennings LK., Tam J., Melnyk RA., Parsek MR, Sheppard DC., Wozniak DJ., Howell PL. (2016) Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms. Science Advances. 2(5): e1501632.

Henriet SS, van de Sande WW, Lee MJ, Simonetti E, Momany M, Verweij PE, Rijs AJ, Ferwerda G, Sheppard DC, de Jonge MI, Warris A. (2016) Decreased cell wall galactosaminogalactan in Aspergillus nidulans mediates dysregulated inflammation in the Chronic Granulomatous Disease Host. J Interferon Cytokine Res. May 4.

Lee MJ, Geller A, Bamford NC, Liu H, Gravelat FN, Snarr BD, Le Mauff F, Chabot J, Ralph B, Ostapska H, Lehoux M, Cerone RP, Baptista SD, Vinogradov E, Stajich JE, Filler SG, Howell PL, Sheppard DC*. (2016) Deacetylation of fungal exopolysaccharide mediates adhesion and biofilm formation. mBio 7(2):e00252- 16.

Zoroquiain P, Alghamdi S, Arthurs B, Levin L, Sheppard DC, Ralph B, Burnier J, Burnier MN. (2016) Eyelid Mycetoma Masquerading as Sebaceous Carcinoma. Ophthal Plast Reconstr Surg. epub Feb 12

Takazono T, Sheppard DC*. (2016) Aspergillus in chronic lung disease: Modeling what goes on in the airways. Medical Mycology, epub Nov.

*indicates corresponding author, supervised trainees are underlined

Invited Reviews and Editorials:

Al-Bader N, Sheppard DC*. (2016) Aspergillosis and stem cell transplantation: overview of experimental pathogenesis studies. Virulence, Nov 16;7(8):950-966 Department of Microbiology and Immunology: 2016 Annual Report

Boisvert A., Cheng M, Sheppard DC, Nguyen D. (2016) Microbial biofilms in pulmonary and critical care diseases. Annals of the American Thoracic Society. 13(9):1615-23.

Sheppard DC, Howell PL. (2016) Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria. Journal of Biological Chemistry. Jun 10;291(24):12529-37.

Lee MJ, Sheppard DC. (2016) Recent advances in the understanding of the Aspergillus fumigatus cell wall. Journal of Microbiology, Mar;54(3):232-42

Book Chapters:

Lee MJ, Sheppard DC. The Cell Wall Polysaccharides of Aspergillus fumigatus. In Karl Esser, Dirk Hoffmeister Editors, The Mycota Vol.III: Biochemistry and Molecular Biology, 3rd edition., Springer Press; 2016.

Choe S, Sheppard DC*. Bioremediation of Arsenic using Aspergillus and other Fungi. Aspergillus Systems: Biology to Biotechnology, Elsevier Press 2016.

Conferences:

Invited Speaker, IUBMB Frontiers in Glycoscience: Host-pathogen interactions. Taipei, Taiwan. Biofilm exopolysaccharides at the hostpathogen interphase. Dec 12 2016

Invited Speaker Immunocompromised Host Society Meeting, Santiago, Chile. Enhancing delivery of antifungals to pulmonary lesions – intracellular antifungals and antibiofilm therapeutics. Nov 14 2016.

Invited Seminar, Sick Kids Molecular Structure and Function Program. Toronto, Ontario. Biofilm exopolysaccharides, a broad antimicrobial target. Sept 26 2016.

Faculty in Residence, Molecular Mycology of Pathogenic Fungi Summer Course, Marine Biology Laboratories, Woods Hole, Massachusetts. Aspergillus galactosaminogalactan: The long and winding road from virulence factor to therapeutic target. June 22 2016.

Invited Speaker, New research approaches in the field of Cystic Fibrosis: from bench to bedside, Cystic Fibrosis Quebec Symposium, Montreal Qc. Aspergillus and Cystic Fibrosis: Modelling what happens in the airways. May 5 2016

Invited Speaker, Infectious Diseases in Hematology Forum. Beijing, China. From the bench to the bedside – new approaches to treat refractory fungal infection. April 16, 2016

Invited Speaker, 26nd European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, Netherlands. Treatment of refractory fungal infections: New therapies under development. April 10 2016

Invited Speaker, 42nd Annual Meeting of the European Society of Blood and Marrow Transplantation. Valencia, Spain. Treatment of refractory fungal infections: New therapies under development. April 2 2016 Department of Microbiology and Immunology: 2016 Annual Report

Keynote Speaker, British Society of Mycology Annual Meeting, Dublin, Ireland. Intracellular antifungals and host-pathogen interactions – can we induce a perfect storm? March 21 2016

Invited Speaker, 7th Advances Against Aspergillosis, Manchester, UK. Pathogenesis of airway colonization with A. fumigatus – modeling what goes on in the airways. March 3 2016

Visiting Professor, Centre of Advance Research in Medical Mycology, Postgraduate Institute of Medical Education & Research, Chandigarh, India. Improving Outcomes in Invasive Aspergillosis - from the Bench to the Bedside. Feb 27 2016.

Invited Speaker, Infektiologischer Workshop auf der herzchirurgischen Intensivstation. University of Cologne, Cologne, Germany. Aspergillus in the ICU: integration of molecular diagnostics. Feb 11 2016.

STEVENSON, Mary

Publications:

Zhou, Z., Stevenson, M.M., Geary, T.G. and Jianguo, X. Comprehensive transcriptome meta-analysis to characterize host immune responses to helminth infections. PLoS Negl. Trop. Dis. 10: e0004624, 2016. doi: 10.1371/journal.pntd.0004624.

Valanparambil, R.M., Tam, M., Jardim, A, Geary, T.G. and Stevenson, M.M. Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived cells that suppress CD4+ Th2 responses and promote chronic infection. Mucosal Immunol. 2016 Apr 13. doi: 10.1038/mi.2016.36.

Moradin, N., Torre, S., Gauthier, S., Tam, M., Hawari, J., Vanderdruyssenm K., De Spiegeleer, B., Fortin, A., Stevenson, M.M. and Gros, P. Cysteamine broadly improves the activity of artemisinin against blood stage and cerebral malaria. Malaria J. 15: 260, 2016. doi: 10.1186/s12936-016-1317-3.

Hang, L., Blum, A.M., Kumar, S., Urban, J.F. Jr., Mitreva, M., Geary, T.G., Jardim, A., Stevenson, M.M., Lowell, C.A., and Weinstock, J.V. Down-regulation of the Syk signaling pathway in intestinal dendritic cells is sufficient to induce dendritic cells that inhibit colitis. J. Immunol. 197: 2948-2957, 2016. doi: 10.4049/jimmunol.1600063.

Meli, A.P., Fontés, G, Avery, D.T., Leddon, S.A., Tam, M., Elliott, M., Ballesteros-Tato, A., Miller, J., Stevenson, M.M., Fowell, D.J., Tangye S.G., and King, I.L. The integrin LFA-1 controls T follicular helper cell generation and maintenance. Immunity 45: 831-846, 2016. doi: 10.1016/j. immuni.2016.09.018.

Conferences/Seminars:

Soup and Science, Faculty of Science, Title: What can mice teach us about the immune response to malaria? January 22, 2016

Oral presentation judge, 16th Annual Quebec Molecular Parasitology Symposium, Center for Host- Parasite Interactions, McGill University, MacDonald Campus, June 6-7, 2016

Department of Microbiology and Immunology: 2016 Annual Report

TROTTIER, Claire

Conferences:

Chen L, Dore S, Orjuela-Laverde M, and Trottier C (2016) Using Peer Feedback as a Teaching and Learning Tool. Supporting Active Learning and Technological Innovation in Science Education (SALTISE) Conference, Montreal, QC. (Participant in panel discussion).

Haffie T, Laferriere T, Winer L, Trottier T, Bielaczyc K, and Charles E (2016) When the going gets tough: Resilience in the face of failure. Supporting Active Learning and Technological Innovation in Science Education (SALTISE) Conference, Montreal, QC. (Participant in panel discussion).

Invited to create and facilitate workshop: Alternative forms of assessment: lessons from Microbiology & Immunology (April 2016) Dawson Active Learning Community, Dawson College. (Invited talk).

WAINBERG, Mark

Publications:

Xu HT, Colby-Germinario SP, Hassounah S, Quashie PK, Han Y, Oliveira M, Stranix BR, and Wainberg MA. Identification of a pyridoxine-derived small-molecule inhibitor targeting dengue virus RNA-dependent RNA polymerase. Antimicrob. Agents Chemother. 2016. 60(1):600-608

Brenner B, Thomas R Blanco J, Ibanescu R-I, Oliveira M, Mesplede T, Golubkov O, Roger M, Garcia F, Martinez E. Wainberg MA. Development of a G118R Mutation in HIV-1 Integrase following a Switch to Dolutegravir Monotherapy Leading to Cross-Resistance to Integrase Inhibitors. Journal of Antimicrobial Chemotherapy 2016. 71(7):1948-53. Doi:10.1093/jac/dkw071

Anstett K, Cutillas V, Fusco R, Mesplede T, and Wainberg MA. The polymorphic substitution E157Q in HIV- 1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity. Journal of Antimicrobial Chemotherapy 2016. 71(8):2083-8. doi:10.1093/jac/dkw109

Otis J, McFadyen A, Haig T, Blais M, Cox J, Brenner B, Rousseau R, Emond G, Roger M, Wainberg MA, The Spot Study Group. Beyond condoms: risk reduction strategies among gay, bisexual, and other men who have sex with men receiving rapid HIV testing in Montreal, Canada. AIDS Behav. doi 10.1007/s10461-16- 1344-7.

Wang Z, Pan Q, Gendron P, Zhu W, Guo F, Cen S, Wainberg MA, Liang C. CRISPR/Cas9-derived mutations both inhibit HIV-1 replication and accelarated viral escape. Cell Reports 15, 1-9, 2016. Http://dx.doi.org/10.1016/j.celrep.2016.03.042

Pham HT, Mesplede T, Wainberg MA. Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses. Retrovirology 2016. 13:31. Doi 10.1186/s12977-016-0265-x

Liang C, Wainberg MA, Das AT and Berkhout B. CRISPR/Cas9: a double-edged sword when used to combat HIV infection. Retrovirology 2016. 13:37. DOI 10.1186/s12977-016-0270-0. Department of Microbiology and Immunology: 2016 Annual Report

Oliveira M, Ibanescu RI, Thi Pham H, Brenner B, Mesplède T, and Wainberg MA.The M184I/V and K65R nucleoside resistance mutations in HIV-1 prevent the emergence of resistance mutations against dolutegravir. AIDS 2016. 30(15):2267-73. DOI 10.1186/s12977-016-0270-0.

Brenner BG, and Wainberg MA. Clinical benefit of dolutegravir in HIV-1 management related to the high genetic barrier to drug resistance. Virus Research (In Press)

Isitman G, Lisovsky I, Tremblay-Mclean A, Kovacs C, Harris M, Routy JP, Bruneau J, Tremblay C, Wainberg MA, Bernard N. Antibody dependent cellular cytotoxicity activity of effector cells from HIV infected Elite and Viral Controllers. AIDS Research and Human Retroviruses 2016. 32(10-11):1079-1088.

Brenner BG and Wainberg MA. We need to use the best antiretroviral drugs worldwide to prevent HIV drug resistance. AIDS 2016. 30:2725-2727.

Book Chapters, reviews, editorials, commentaries:

Wainberg MA. Early HIV treatment to forestall drug resistance. The Lancet Infectious Diseases Published online January 28, 2016 http://dx.doi.org/10.1016/S1473-3099(16)00013-X

Wainberg MA, Han YS, and Mesplede T. Might Dolutegravir be part of a functional cure for HIV? Canadian Journal of Microbiology 2016. 62:1-8

Mesplede T, Wainberg MA. Will LEDGIN Molecules Be Able to Play a Role in a Cure for HIV Infection? EBiomedicine 2016. 8: 14-15.

Hassounah SA, Mesplede T, Wainberg MA. Nonhuman Primates and Humanized Mice for Studies of HIV- 1 Integrase Inhibitors: A Review. Pathogens and Immunity 2016. 1(1)41-67.

Han YS, Mesplede T, Wainberg MA. Differences among HIV-1 subtypes in drug resistance against integrase inhibitors. Infection, Genetics and Evolution 2016. 46(2016)286-291.

Wainberg MA. Opinion: As we fight Zika and Ebola, let’s not forget HIV/AIDS. The Gazette. July 15, 2016.

Brenner BG, Wainberg MA. We need to use the best antiretroviral drugs worldwide to prevent HIV drug resistance. Editorial Comment. AIDS 30(17):2725-2727

Wainberg MA, Hull M, Girard PM, Montaner J. A key to achieving the UNAIDS 90-90-90 Target: Financial Incentives for HIV Testing. Lancet 2016. 16(11): 1215-1216.

Wainberg MA and Lever AML. HIV and Zika: When Will We Be Able to End these Epidemics? Retrovirology 2016. 13:80

Wainberg MA. Double standard on antiretrovirals hampers the fight against AIDS. The Gazette newspaper, Montreal. Opinion article, November 29, 2016.

Conferences: Department of Microbiology and Immunology: 2016 Annual Report

MOST Institute, Beijing China. Drug resistance profiles of HIV Integrase Inhibitors. March 2016.

School of Medicine. University of Nanjing. Nanjing, China. Can Currently Available Drugs Be Used to Functionally Cure HIV Infection. March 2016.

Case Western Reserve University. Center for AIDS Research. Is drug resistance inevitable for anti-HIV integrase inhibitors? March 2016.

Consultation on HIV Drug Resistance. National Institutes of Health. National Institute of Allergies and Infectious Diseases. Bethesda, MD. Not All Drug Regimens Are Created Equal. May 2016.

The New York Course. New York, NY. (Invited Speaker) Is HIV Drug Resistance Still Relevant? May 2016.

ISHEID Conference. Marseille, France. The R263K Mutation in HIV Integrase decreases HIV integration over multiple cycles of infection. May 2016.

U. of Toronto. Global Health Day. (Invited Speaker) Progress toward ending the HIV epidemic. June 2016.

Camden Infectious Diseases Clinic, Camden, NJ. Should all HIV patients now be started on an integrase inhibitor? September 2016.

International H IV Conference. Kinshasa. Democratic Republic of Congo. (Invited Speaker). Management of HIV Disease in 2016 and the Future. December 2016.

Conference on Development of Antiretroviral Targeted Therapy (DART).(Invited Speaker). Nucleosides for HIV: Past, present and future. (Recipient of the Gertrude Elion Award). December 2016. Department of Microbiology and Immunology: 2016 Annual Report

5. Grants

Granting Annual Funding Faculty Member Role Project Title Agency Total Period

ARCHAMBAULT, Host factors involved in polyomarivus genome PI CIHR $139,612 2016-2019 Jacques replication

Immune modulatory bacteria for the treatment of PI MSD $100,000 2014-2016 chronic rhinosinusitis

COUSINEAU, Bacterial group II introns: splicing, function and PI NSERC $50,000 2013-2018 Benoit evolution

Heme and colitis: Lactococcus lactis for intestinal PI MDTC $10,000 2016-2017 delivery of heme scavenging proteins.

Cellular and molecular mechanisms regulating PI NSERC $30,000 2012-2019 immunoglobulin A production

New Investigator Award (A), Salary Support (MSH- PI 122823), “Functions of Nod1 and Nod2 in host CIHR $60,000 2012-2017 resistance.”

Programme de bourses de chercheur-boursier FRITZ, Jörg PI “Junior 1” Volet “Fondamental” Award, “Functions of FRQS $37,526 2013-2017 Nod1 and Nod2 in host resistance.”

Tracing Control Mechanisms of Mucosal Immunity in PI CIHR 210,824 2016-2023 Health and Disease (Foundation Grant)

GET-FACTS: Genetics, Environment and Therapies: Co-PI CIHR $81,500 2013-2018 Food Allergy Clinical Tolerance Studies

Rspo2: Tipping the balance between intestinal PI CIHR $135,000 2014-2019 homeostasis versus dysfunction

Salary Award Fonds de recherché du Quebec- Sante PI FRQS $39,919 2016-2017 (Chercheur-boursier, Senior) GRUENHEID,

Samantha Bacterial effector proteins as tools to study cell PI NSERC $41,000 2014-2019 biology (Discovery Grant)

A Syst-OMICS approach to ensuring food safety and Genome Canada Co-I $2,450,000 2015-2019 reducing the economic burden of salmonellosis Genome Quebec

Novel pathways in T lymphocyte differentiation and PI NSERC $29,000 2015-2021 function (Discovery Grant) KING, Irah The effect of anti-mycobacterial antibiotics on the PI MDTC $15,000 2015-2016 microbiota and host immunity to tuberculosis Department of Microbiology and Immunology: 2016 Annual Report

Granting Annual Funding Faculty Member Role Project Title Agency Total Period

PI CRC Tier II in Humoral Immunity CRC $100,000 2013-2018

T follicular helper cell differentiation and function in PI CIHR $150,000 2013-2018 immunity and infection

Regulatory mechanisms of innate T cells in skin PI CIHR $150,607 2016-2013 homeostasis and disease.

Interrogating immune-bacteriophage dynamics to Kenneth Rainin Co-PI US$100,000 2016-2017 mitigate intestinal inflammation Foundation

PI Molecular Regulation of Dendritic Cell Function CIHR $158,178 2013-2018

PI miRNA regulation of Dendritic Cell Function NSERC $26,000 2012-2010

CIHR Industry Repurposing an Attenuated Salmonella typhimurium Co-PI partnered (Aviex $40,000 2016-2018 as a Novel Vector for Mucosal Vaccine Delivery KRAWCZYK, Connie Inc.

Exploiting plant-made vaccines to protect the elderly Co-PI FPQIS $48,000 2014-2018 against respiratory viruses.

Exploiting plant-made vaccines to protect the elderly Co-PI Genome Quebec $61,540 2014-2018 against respiratory viruses

Emerging roles for phosphoethanolamine LE MOUAL, Hervé PI modification of bacterial lipopolysaccharide NSERC $35,000 2014-2019 (Discovery Grant)

System Immunobiology of S. aureus Pathobiosis: Role PI CIHR $150,060 2015-2020 of the AhR Gene Program

Regulation of T cell Activation by Stomatin-Like PI CIHR $148,373 2013-2018 Protein 2

PI Tier I Canada Research Chair in Human Immunology CRC $200,000 2012-2016 MADRENAS, Joaquin Immune modulatory bacteria for the treatment of MSD/McGill, Faculty of Co-PI Medicine, Translational, $100,000 2015-2016 chronic rhinosinusitis Research

Co-PI Canadian National Transplant Research Program CIHR $2,400,000 2013-2018

Mortality risks in later life from exposure to CIHR Co-PI pandemic influenza in early life: the 1890 and 1918 $90,856 2013-2016 Operating influenza in Canada.

MARCZYNSKI, Bacterial chromosome replication control by novel PI CIHR $137,712 2013-2018 Gregory T. proteins. Department of Microbiology and Immunology: 2016 Annual Report

Granting Annual Funding Faculty Member Role Project Title Agency Total Period

PI Control of Leishmania Pathogenesis. CIHR $149,600 2013-2018

Global Health Co- Development of a safe and effective live attenuated Innovation $104,139 MATLASHEWSKI, applicant 2015-2017 vaccine for Leishmaniasis Technology Fund USD Greg

Grand Challenge Canada Co- Point of care diagnosis of Visceral leishmaniasis in in conj. with $197,400 2011-2016 applicant India. Bill and Melinda Gates Foundation

The active human gut microbiota and its phage CIHR PI regulators in health and disease ($15,000 research $100,000 2015-2020 allowance; $85,000 salary support). CRC, Tier 2

The active human gut microbiota and its phage CFI PI John R. Evan’s $50,000 2015-2020 regulators in health and disease. Leader’s Fund

Bill and Melinda Gates Role of phages in the gut and implications for PI Foundation + Grand $100,000 2015-2017 stunting in children. Challenges Global Health Programs

Dynamics of phage ecology in the gut (Discovery PI NSERC $29,000 2016-2021 Grant) MAURICE, Corinne MIMM Co-PI Bacterial dysbiosis and the onset on periodontitis. $20,000 2016-2017 Radcliffe Bequeath

Heme and colitis: Lactococcus lactis for intestinal Co-PI MDTC Award $10,000 2016-2017 delivery of heme scavenging proteins

Metabolic dynamics of the human gut microbiota in PI CIHR $100,000 2016-2017 dysbiosis

PI Dynamics of lysogeny in the gut FRQNT $25,000 2016-2018

PI Dynamics of lysogeny in the gut – EQUIPMENT FRQNT $43,000 2016-2018

The active human gut microbiota and its phage PI CIFAR $50,000 2016-2018 regulators

Hemozoin and Malaria Biomarkers: Role in the PI modulation of inflammatory responses and CIHR $150,000 2012-2017 Operating Grant development of Malaria-related Pathologies

Role of Iron in the Regulation of PTPs: Impact on Cell OLIVIER, Martin PI NSERC $48,000 2012-2017 Signaling and Functions Discovery Grant

Subversion of Macrophage Signaling by the PI CIHR $168,000 2011-2016 Protozoan Parasite Leishmania Operating Grant Department of Microbiology and Immunology: 2016 Annual Report

Granting Annual Funding Faculty Member Role Project Title Agency Total Period

Deciphering the signaling mechanisms underlying Co-PI Ebola virus-mediated inflammatory response upon CIHR $59,785 2015-2017 interaction/entry with human macrophages

Translational control of gene expression in Foxp3+ PI CIHR $165,000 2012-2017 regulatory T cells Operating Grant

Exploiting plant-made vaccines to protect the elderly Co-PI FPQIS $300,000 2014-2019 against respiratory viruses

CIHR Co-PI Molecular alterations in type I diabetes $169,478 2014-2017 Operating Grant

Unraveling the Mechanism of Action of the CIHR PICCIRILLO, Ciriaco Co-PI Adiponectin Receptor Pathways in a Humanized in $280,000 2016-2020 Operating Grant vitro Model of Carotid Plaque Instability.

Antigen-specific functional properties and molecular PI profiling of autoreactive T-cells in individuals at risk CIHR $390,000 2016-2021 Operating Grant for type 1 diabetes.

Improving Influenza Immunization Responses in Rheumatoid Arthritis: A Strategy to Enhance The Arthritis Co-PI n/a 2016-2019 Protection Against a Preventable Cause of Death in Society an at-Risk Population?

Regulation of CD4 T cell antigen sensitivity by PI NSERC $29,000 2016-2022 cytokines

Régulation de la fonction des cellules T CD8 par les PI FRQ-S $28,798 2016-2020 cytokines (research allocation)

Régulation de la fonction des cellules T CD8 par les PI FRQ-S $20,000 2016-2019 RICHER, Martin cytokines (Salary Award)

PI CIHR New Investigator Salary Award CIHR $15,000 2016-2021

Investigating the effect of biguanides on T cell Immunomet Co-PI $120,000 2016-2017 function Therapeutics

Interrogating Dengue Virus (DENV) RNA Structure in PI FRQNT $25,400 2015-2017 Human and Mosquito Cells

5th Canadian Symposium on Hepatitis C Virus: “We’re PI CIHR $10,000 2015-2016 SAGAN, Selena M. not done yet: remaining challenges in HCV”

Mechanisms governing Hepatitis C virus genome PI CIHR $136,738 2014-2019 stability and viral RNA accumulation Operating Grant Department of Microbiology and Immunology: 2016 Annual Report

Granting Annual Funding Faculty Member Role Project Title Agency Total Period

Using live cell SHAPE to investigate the dynamic PI NSERC $35,000 2014-2019 structure of HCV RNA during the viral life cycle Discovery Grant

Can health-care associated hepatitis C outbreaks occur when intravenous medication vials are Queen’s Co-PI $19,478 2016-2018 accessed with clean needles and syringes for use in University CTAQ multiple patients?

Recombinant hydrolases as anti-biofilm therapies for PI CIHR $151,459 2015-2016 Aspergillus infections Proof of Principle

Mechanisms of Aspergillus fumigatus induced Cystic Fibrosis PI progression of chronic airway disease in cystic $77,150 2015-2018 fibrosis Canada

PI Carbohydrate Acetylation in Pathogenesis GlycoNET $133,119 2015-2018

SHEPPARD, Don Understanding and exploiting the activity of galectin- 3 as a non-canonical pattern recognition receptor for PI GlycoNET $133,119 2015-2018 fungal cell wall glycans in order to improve outcomes during fungal infections

Molecular mechanisms of Invasive Aspergillosis (RI- PI CIHR $16,000 2015-2016 MUHC sub-in to McGill) Operating Grant

Mechanisms of Aspergillus induced chronic airway PI CIHR $87,107 2012-2017 disease Operating Grant

Iron homeostasis and the pathogenesis of malarial PI CIHR $113,101 2013-2018 STEVENSON, Mary anemia

PI Studies on HIV Drug Resistance CIHR $175,000 2012-2017 WAINBERG, Mark PI Curative Approaches to HIV CIHR $135,000 2014-2017 Department of Microbiology and Immunology: 2016 Annual Report

Section III Teaching and Learning Department of Microbiology and Immunology: 2016 Annual Report

6. Initiatives and Innovations related to Teaching Programs

A. Graduate Programs

In 2016, the MIMM Graduate Program admitted a record number of students. The 30 new students, who joined the department in 2016, received a total of $127,750 in Graduate Excellence Fellowships. Departmental fellowships, including Graduate Excellence Fellowships, were awarded to 26 returning graduate students for a total of $100,181. Travel awards were granted to 9 trainees to support the presentation of their work at national and international conferences.

In this era of limited academic research funding, it is worth mentioning that, in 2016, twenty-two MIMM graduate students were financially supported through highly competitive provincial/national/international studentships for a total of $432,678. Notably, Sophie Cousineau (Dr. Sagan lab) was awarded a prestigious Vanier Canada Graduate Scholarship. The Vanier CGS program aims to attract and retain world-class doctoral students demonstrating sustained academic excellence, high research potential and leadership skills.

Congratulations to Vincent Cutillas (Dr. Wainberg lab) and Brendan Snarr (Dr. Sheppard lab) who received the 2016 Wilfred Yaphe awards for the best MSc and PhD final seminars, respectively. Hats off to Dr. Robert Scarborough (Dr. Gatignol lab) who was granted The Wares Family Postdoctoral Fellowship.

Departmental Gala awards were attributed to Brendan Cordeirio (Graduate Mentorship Award), Travis Ackroyd (MIGSA Graduate Extra-Curricular Student of the year) and Patrick Lypaczewski (MIGSA Graduate McGill Award).

In terms of program improvement, 2016 was the year in which we implemented a workshop on the ethics of scientific research and publication, and the distinctions between appropriate scientific conduct and scientific misconduct. All newly admitted graduate students must now complete this workshop during their first term in residence. This highly valuable initiative was made possible by the dedicated work of Dr. Claire Trottier, our education specialist, and the collaboration of the Integrated Program in Neuroscience. The workshop comprises 2 modules of 4 hours that include short lectures and case studies in small groups led by Faculty facilitators. Thanks to our Faculty members who participated as facilitators.

On May 20th 2016, the Annual Graduate Research Day celebrated its 5th anniversary. Dr. Adolfo Garcia- Sastre, from the Icahn School of Medicine at Mount Sinai, delivered the keynote lecture. At this event, 7 prizes totalizing $1,900 were awarded for the best oral and poster presentations.

Department of Microbiology and Immunology: 2016 Annual Report

B. Undergraduate Programs In 2016, our Department continued the redevelopment of our undergraduate program. Highlights include:

1) Curriculum mapping: Dr. Claire Trottier conducted a detailed survey of all MIMM course coordinators to gather data on each course offered by the Department. Coordinators were asked to identify the program outcomes that are included in their own courses, the level of depth achieved for each outcome, and whether or not these outcomes are directly assessed for marks. They were also asked to report on workload distribution during the semester. An identical survey was also completed by undergraduate students in order to determine student perceptions of these courses. This data was used to identify gaps and determine priorities for discussion at an upcoming Faculty Teaching Retreat in September 2017.

2) Polling @ McGill integrated into multiple courses: This in class response software was used in two courses in the Department during the Fall 2016 semester: MIMM211 and MIMM324. This software allows professors to ask questions during class, and for student to respond in real time using an electronic device.

3) Redevelopment of MIMM214: Following Dr. Madrenas’ departure in Fall 2016, Dr. Trottier was given the task of teaching this course, which is the largest class offered by our Department. Dr. Trottier spent a significant amount of time redeveloping this course in the Fall of 2016, in order to create novel assessments and in class activities to further increase student engagement.

4) Faculty development: Dr. Trottier organized a workshop specifically for MIMM Faculty in May 2016. This workshop allowed the 12 Faculty members to learn about innovative teaching and assessment methods being used by their colleagues in this Department. Faculty members gave excellent feedback following this workshop and requested another workshop on assessment. Dr. Trottier then joined a Faculty Development team in the Faculty of Medicine with Dr. David Ragsdale and Dr. Maria Orjuela-Laverde to lead an Assessment Workshop in December 2016. This workshop was attended by MIMM faculty and professors from other Departments.

5) Virology ribbon: Course coordinators and instructors from our two virology courses (MIMM324 and MIMM466) and Dr. Trottier met in Fall 2016 to discuss how to improve the virology ribbon and better coordinate between the classes.

6) Planning for teaching retreat: The Undergraduate Committee began planning for a Departmental Teaching Retreat to be held in Fall 2017. We identified priorities using data from the curriculum mapping.

Department of Microbiology and Immunology: 2016 Annual Report

7. Success Stories of Faculty and Students

January

 Steven Sutcliffe, who will be joining the Maurice lab in January 2016. His graduate work will focus on the role of bacteriophages in the gut microbiota.

February  Saleema Nawaz publishes her book Bone & Bread: it has been selected for this year's Canada Reads on the CBC.  Drs. Ward, Ndao and Krawczyk receive CIHR-Industry award  Award winners of the Canadian Society for Immunology: Alexandre Meli - CSI Award Barbara Mindt - CSI Award Claudia Duerr - Greenberg Award

March

 Gautham Krishnaraj, MISA president, led a delegation of 9 McGill students as the director of IRSAM's ecosoc portfolio at the United Nations in New York on February 4th. He provided a statement as a youth representative, and co-facilitated the Official NGO briefing of the Civil Society Forum for Sustainable Development.

 Dr. Mark A. Wainberg receives the 2015 AMMI Canada Lifetime Achievement Award

 Dr. Irah King receives the New Investigator Award from the Canadian Society for Immunology

 Dr. Corinne Maurice receives the Tier 2 Canada Research Chair in Gut Microbial Physiology

 Dr. Joyce Wilson, Associate Professor, Virology (University of Saskatchewan) was a Visiting Professor in Dr. Sagan’s Laboratory from March 1st, 2016 to May 31st, 2016.

April

 IAN BIES, MIMM Alumni 2015, was newly being appointed as the General Counsel for Northern Biologics Inc.

 NAVID ZUBERI, grade 10 student at Centennial Regional High School, won the silver medal at the Montreal Regional Science and Technology Fair, the highest distinction award and a bursary from the McGill Faculty of Science. Dr. Marczynski supervised his molecular biology experiments. The poster was entitled ‘’Transform to Reform’’ and addressed E. coli antibiotic resistance.

 ALI MOHAMMED, U2, received the inaugural MACSS scholarship held by the McGill Anatomy and Cell Biology Student Society. It was awarded on March 30th 2016 “For exceptional character, commitment, and achievement in extracurricular endeavours” with regards the work done (in collaboration with the MIMM department) on Y: the Immunology Podcast.

Department of Microbiology and Immunology: 2016 Annual Report

May

 Dr. Benoît Cousineau was recognized for his academic advisory role by the Dean of Students on April 13, 2016.

 Félix LaRoche-Johnston (M. Sc. student / Dr. Cousineau’s lab) received an FRQNT MSc studentship award.

 Drs. Corinne Maurice & Martin Richer received NSERC grants.

 Dr. Martin Richer was awarded an FRQS Chercheurs-Boursiers Junior 1 salary award.

 Dr. Wainberg was inducted at the Canadian Medical Hall of Fame in Hamilton, Ontario on April 14th.  Graduate student Logan Smith was awarded a CIHR CGS-M scholarship.  Graduate student Ryan Pardy was awarded an NSERC CGS-M scholarship.

 Undergraduate student Stefanie Valbon was awarded a summer studentship from the McGill Integrated Cancer Research Training Program for a project co-supervised by Dr. Russell Jones and Dr. Martin Richer.

June

 Dr. Berghuis appointed as Chair of Biochemistry

 On May 6th, Dr. Madrenas was interviewed by Noelia Garcia Palomares, a journalist from the Spanish magazine elEconomista.es. The meeting was also attended by Laura Ballesteros, Cultural and Academic Relations Officer of the Canadian Embassy in Spain. During the meeting, they reviewed research and education in Canada but more importantly, explored the opportunities to facilitate bilateral exchanges in Science and Technology to promote collaborations at multiple academic levels.

 Dr. Fritz awarded Academic Tenure

 New autoclave and glass washing units

 Dr. Nicolas Cermakian nominated for Faculty Honour List

 Dr. Olivier Won the Wardle Award

 Mohammadali Khan Mirzaei joins Maurice Lab as a Postdoctoral fellow

 Clare Fogarty received Cavazzoni Undergraduate Student Research Award

 Felix LaRoche Johnston received NSERC Award

 David Salem received FRSQ Award

Department of Microbiology and Immunology: 2016 Annual Report

September

 Connie Shen, a U2 MIMM student, presented a poster describing McGill's success with Small World Initiative (SWI) at the SWI symposium during the American Society of Microbiology meeting this past June in Boston

 Dr. Hervé Le Moual appointed as Director of MDCTC

 Dr. Corinne Maurice appointed as CIFAR Scholar

 Dr. Maya Saleh received research grants

 Faculty Members received CIHR Grants: . Alexandre Orthwein . Andrés Finzi . Anne Gatignol . Ciriaco Piccirillo . Corinne Maurice . Dao Nguyen . Irah King . Jörg Fritz . Judith Mandl . Marcel Behr . Maya Saleh . Philippe Gros . Rongtuan Lin

 Dr. Hervé Le Moual and Dr. Irah King received CFI grants for a period of three years  Ms. Inna Roo received the Anne McCormick Award

October

 Dr. Ciriaco A. Piccirillo's lab received a 2M$ CIHR grant

November

 Sophie Cousineau wins Vanier Scholar 2016

December

 Félix LaRocheJohnston, Caroline Monat, Samy Coulombe and Dr. Benoit Cousineau won the First prize in Molecular Biology Poster presentation on, "Capture of mRNA fragments at the splice junction of bacterial group II introns" in the 19th annual Chemistry and Biochemistry Graduate Research Conference at Concordia University

 Dr. Mary Stevenson became a Fellow of the American Society of Tropical Medicine and Hygiene (ASTMH) at the 65th Annual ASTMH meeting held November 1317, 2016 in Atlanta, GA Department of Microbiology and Immunology: 2016 Annual Report

 Adam Hassan presented at the Journée des Étudiants du Réseau SIDA et Maladies Infectieuses de la FRSQ on November 4th, 2016. The conference was held by various Master's, PhD and post- doctoral students who worked on HIV. Adam was the only undergraduate research student. Department of Microbiology and Immunology: 2016 Annual Report

MIMM Students who received M.Sc. Degrees in 2016 Student Thesis Title Supervisor Ackroyd, Travis “The role of the cystic fibrosis transmembrane Dr. Samantha Gruenheid conductance regulator in host protection against «Citrobacter rodentium» intestinal infection.” Carnevale, Giustino “The regulation of skin immunity of CD109 with Dr. Irah King relevance to psoriatic-like inflammation.”

Domi, Anisa “Identifying mechanisms responsible for regulating Dr. Connie Krawczyk expression of PCGF6, a repressor of DC activation.” Dunn, Jonathan “Harnessing the power of stem cells in vaccine Dr. Maziar Divangahi against «Mycobacterium tuberculosis.”

Fan, Huang “The anti-HIV-1 host protein MxB promotes cell Dr. Chen Liang apoptosis.”

MacLean, Emily “Modulation of cutaneous leishmaniasis by sand fly Dr. Martin Olivier fever Sicilian virus coinfection.” Ackroyd, Travis “The role of the cystic fibrosis transmembrane Dr. Samantha Gruenheid conductance regulator in host protection against «Citrobacter rodentium» intestinal infection.”

MIMM Students who received Ph.D. Degrees in 2016 Student Thesis Title Supervisor Singhroy, Diane “Host-virus interactions: innate immunity in wild- Dr. Mark Wainberg type and drug-resistant HIV-1 infections.” Bin Dhuban, Khalid “Functional characterization and biomarker Dr. Ciriaco Piccirillo discovery of FOXP3+ regulatory T cells in human health and disease.” Department of Microbiology and Immunology: 2016 Annual Report

8. Departmental Activities See Appendixes: Tables 1 to 4

Department of Microbiology and Immunology: 2016 Annual Report

Guest Speakers in the Infection and Immunity Seminar Series (January to December 2016) Date Speaker Title An Essential DNA-binding Protein Coordinates Chromosome Replication and January 21 Dr. James A. Taylor Segregation in the Model Organism Caulobacter crescentus Shaping of host immunity by the commensal microbiota January 28 Dr. Dan Littman

Dr. Alexandre Orthwein Cell Cycle and DNA double-strand break repair: Implications for genome stability February 4 and B-cell biology

Mucosal antiviral defense: how redox-dependent processes control the quantitative February 11 Dr. Nathalie Grandvaux and qualitative cytokine response

Dr. Jacques Corbeil Can we measure everything and how to navigate an ocean of data? February 18

Development of Novel Ribonucleoside Analog Inhibitors for Treatment of Hepatitis February 25 Dr. Maryam Ehteshami C Virus Infection and Beyond

Dr. Heather Melichar Revisiting the affinity model: the spatio-temporal dynamics of thymic selection March 3

Dr. Maria Fernandes The functional characterization of the inhibitory receptor Clec12A: Potential March 10 implications for chronic inflammatory diseases

Pathophysiology of Multiple Sclerosis March 17 Dr. David Hafler

Dr. Javier Marcelo Di Making better antibodies : mutate it and break it, but not too much March 24 Noia

Inflammasome recognition of bacterial pathogens March 31 Dr. Vijay Rathinam

Dr. Manu Rangachari Immune checkpoint signaling: a potential target in autoimmunity April 7

Mapping the targetome of prokaryotic small RNAs April 14 Dr. Éric Massé

Dr. Ken H. Cadwell April 21 Gene-microbe interactions in inflammatory disease

Hepatitis C virus life cycle promotion by miR-122: does the virus really need miR- April 28 Dr. Joyce Wilson 122?

Dr. Lawrence Goodridge Insights from the Inside: Whole genome sequencing reveals a new group of September 22 prophages within Escherichia coli and Salmonella enterica

Dr. Gregory Sonnenberg Immune regulation of intestinal health October 6

Dr. Laurent Chatel-Chaix October 13 Morphological and functional remodeling of the cytoplasm by dengue virus

Dr. Helene Decaluwe October 20 Impact of cytokines on adaptive T cell responses to chronic viral infections

Dr. Bebhinn Treanor Novel mechanisms regulating B-cell activation November 3

Dr. Moutih Rafei The hidden side of Interleukin-21 November 10

Manipulation of the gut microbiota for the prevention and treatment of gut November 17 Dr. Karen Madsen inflammation Department of Microbiology and Immunology: 2016 Annual Report

Dr. Michel Bergeron November 24 From Pasteur to the Genome: the Diagnostic Revolution

Dr. Nicole Bernard December 1 NK cell responses to HIV infected cells

Dr. Eric Cohen HIV Accessory Proteins and HIV Persistence December 8

Dr. Mariela Segura Modulation of the immune response by encapsulated streptococci: demystifying the December 15 role of sialylated capsular polysaccharides Department of Microbiology and Immunology: 2016 Annual Report

Section IV Academic & Community Service Department of Microbiology and Immunology: 2016 Annual Report

9. Academic and Community Service

Educational Outreach Initiatives

The Department engaged again this year in various community outreach initiatives.

- White House Microbiome Initiative: The White House Office of Science and Technology Policy issued a call to action for new commitments to microbiome research from all sectors. MDTC submitted a brief summary of activities and received a positive response on March 7th 2016, asking for information on any new projects in the works, preferably involving collaborations with U.S. universities, companies, or foundations.

- McGill has been awarded a WHO partnership as a Collaborating Center for Research and Training in Parasite Epidemiology and Control. This initiative was led by the Department of Epidemiology and Biostatistics at the Faculty of Medicine with the leadership of Dr. Gyorkos. Several Departments were involved, including MIMM.

- Dawson College invited Departments within the Faculty of Medicine and the Faculty of Science to participate in an information session on February 3rd. Dr. Cousineau (MIMM Chief Academic Advisor) was the representative for that session. Approximately 120 students attended the event where many showed interests to apply to McGill and join the MIMM Department.

- The Microbiology and Immunology Student Association organized information sessions to outreach to CEGEP students. They talked about McGill and informed potential students about the MIMM Department. The Undergraduate Education Committee will be coordinating future outreach initiatives with MISA.

- A wine and cheese was organized in the lobby of the Duff Medical Building as part of the McGill Homecoming celebration. Faculty members, graduate and undergraduate students welcomed back MIMM Alumni during that event.

- Mr. Gautham Krishnaraj (President of MISA) presented at the UN as the director of IRSAM's ecosoc portfolio, leading a delegation of 9 McGill students to the commission for social development. He also facilitated the Official NGO briefing of the Civil Society Forum for Sustainable Development at the UN headquarters in New York.

- Mr. Ali Mohammed initiated a Podcast series on the theme of Infection and Immunity called “Y: the immunology podcasts”. Several episodes (short interviews of about 25 minutes each) have already been recorded and are now posted on iTunes, the McGill Podcast webpage as well as on our departmental webpage. Department of Microbiology and Immunology: 2016 Annual Report

10. Community Involvement (by PI)

Archambault, Jacques

Department :  Member, Graduate committee • Member, Core Facilities Committee • Member, Organization of Gala meeting • U3 academic advisor in replacement of Dr. Samantha Gruenheid

Other :  Editing Reviewer of Journal of Virology (4 manuscripts), mBio (2 manuscripts), Virology (1 manuscript)  Editor-in-chief of The open virology journal (TOVJ)  Member of organizing committee, DNA Tumor Virus Meeting 2016, Montréal, Qc, Canada  (July 18-23, 2016). International meeting.

Briedis, Dalius

Department:  Member, Merit Committee  Member, Graduate Committee

Faculty:  Member, Curriculum Implementation Advisory Group Committee for McGill Medical School  Member, Basic Science Curriculum Committee on details of basic science syllabus of McGill Medical School  Member, Infectious Diseases Subcommittee, Continuing Health Professional Education Committee on Thursday Evening Learning Series Wednesday E-Learning Series

University:  Biohazards Resource Officer, McGill University Laboratory Safety Committee

Other:  Pro-Dean  Reviewer for: - Journal of Infectious Diseases - Clinical Infectious Diseases - Canadian Medical Association Journal - Canadian Journal of Neurological Sciences Department of Microbiology and Immunology: 2016 Annual Report

Cousineau, Benoit

Department:  Member of the Chair Advisory Council  Member of the Seminars Committee  Member of the Core Facility Committee  Microbiology and Immunology Chief Academic Advisor  Microbiology and Immunology Study Away Exchange Advisor  Member of the Travel Award Committee of the Centre for Host‐parasite Interaction (CHPI)  Chair of the Merit Committee (since October 01)  Chair of the Departmental Tenure and Promotions Committee (since October 01)  Chair of the Recruitment and Selection Committee (since October 01)  Introduce Dr Deanna Gibson at the 2016 MDTC retreat (March 15th)  MIMM Representative at McGill Open House  MIMM Representative at Homecoming  MIMM Representative at Alumni Wine and Cheese  MIMM Representative at MISA wine and Cheese  MIMM Representative at Freshman Fair  MIMM Representative at Orientation day for CEGEP students  Presentation at MIMM Orientation session for U1 students  Fundraising for the 2016 MIMM Graduate Research Day

University:  Microbiology Immunology Interim Chair (since October 01)

Other / outside McGill:  Membre du Comité Scientifique du 85e Congrès de l’ACFAS 2017 (McGill University, 8‐12 Mai 2017) - Evaluation of Colloquia - Evaluation of Abstracts (oral and poster presentations)  Judge at the Canada Wide Science Fair (CWSF)  Poster Judge at the 17th Annual Meeting of the Ribo-Club  Presentation at Dawson College Undergraduate Science Fair

Fournier, Sylvie

Department:  Graduate Program Committee Chair  Core Facilities Committee Member  Chair Advisory Committee Member  Seminar Committee Member  Undergraduate Academic Advisor U2  Flow Cytometry and Cell Sorting Facility Director

Faculty  UACC Training Subcommittee Member  UACC Animal use protocol application review Subcommittee Member Department of Microbiology and Immunology: 2016 Annual Report

 Graduate Program Director Committee Member

Other  Member of the Microbiome and Disease Tolerance Centre  Member of Quebec-Ottawa Regional Research and Training Centre of the endMS Research and Training Network  PRO-DEAN - Tong WANG, December 5th, 2016, Department of Mining Materials Eng. - Jalal ARABNEYDI, December 8th, 2016, Department of Electrical Computer Eng. - Tran Khoa PHAN, December 16th, 2016, Department of Electrical Computer Eng.

Fritz, Jorg

Department:  Seminar Committee  Graduate Committee  Internal Grant Review (M. Saleh, M. Richer, E. Seidman)  Host of following seminar speakers: - Kelly McNagny (UBC) - Fabio Rossi (UBC) - Paige Lacy (UBC) - Gregory Sonnenberg (Cornell) - Emmanuelle Charpentier (MPIPBerlin)

Faculty:  McGill University Postgraduate Awards Committee (PGAC) – review of 21 fellowship applications  MIMM Chair Search Committee  Director of Life Sciences Complex Flow Cytometry Facility (2015 - )

Other:  Editorial Board for PLOS One  Reviewer of Journals - Immunology - PLOS One - Frontiers in Immunology - Science Immunology - PLOS Pathogens - Journal of Immunology

- Allergy, Asthma & Clinical Immunology

Department of Microbiology and Immunology: 2016 Annual Report

Gruenheid, Samantha

Department:  Member, Department of Microbiology and Immunology Undergraduate education committee.  Member, Department of Microbiology and Immunology Merit committee.  Department of Microbiology and Immunology Undergraduate academic advisor, 2010-present.  Member, New faculty mentorship committee (Dr. Connie Krawczyk, Dr. Selena Sagan, Dr. Corinne Maurice).

Faculty:  Member, McGill Faculty of Medicine Postgraduate Awards Committee

University:  Member-at-large, McGill University Senate

Other: GRANT REVIEW  NSERC: Discovery Grants, External Reviewer, 2 applications, Fall 2016 competition.  CIHR: Member, CIHR, College of Reviewers, September 2015-present.  Canadian Association of Gastroenterology - Review panel member, PhD studentships competition. - Review panel member, Workshop and Conference Grants. - Selection panel member for CAG and CCC Research awards. - Abstract review and selection of speakers for Canadian Digestive Disease Week Conference.  University of British Columbia/BC Children’s Hospital - External Reviewer, Child & Family Research Institute Investigator Salary Award  Internal Reviewer for McGill - Internal Reviewer, CIHR Project Grants, Martin Richer, John White, Dao Nguyen, Feb. 2016. - McGill Faculty of Medicine Postgraduate Awards Committee: evaluated 16 applications for postdoctoral fellowships.

MANUSCRIPT REVIEW FOR JOURNALS  Nature Microbiology (April 2016)  Scientific Reports (June 2016)  PloS One (October 2016)  Session co-chair. Canadian Digestive Disease Week 2016.  Organizing Committee Member, McGill Research Center on Complex Traits Inaugural Symposium. 2016.  International Young Scientists Mentorship Program (IYSMP). http://iysmp.org/about/ Advisory board member, 2015-present. Department of Microbiology and Immunology: 2016 Annual Report

 Small World Initiative International Teaching Collaborative. Co-leader, Science committee, 2015- present. (http://www.smallworldinitiative.org/committee-leaders/)  Canadian Association of Gastroenterology (CAG), Member, Research Affairs Committee.  Canadian Society of Microbiologists. McGill University Representative, 2013 – October 2016.  With MISA, participated in the sale of microbiology-related hand-made crafts to raise awareness about antibiotic resistance. $500 US net profits were donated to the Small World Initiative to support instructor training to allow under-resourced schools to join SWI.  Interviewed by McGill Tribune on subject of antibiotic resistance. http://www.mcgilltribune.com/sci-tech/molecular-mousetrap-found-to-fight- resistantsuperbugs-091247/  Nominated, Small World Initiative Support Person of the Year 2016.

King, Irah

Department:  Graduate Program Committee, member  Core Facilities Committee, member  Galal Committee, member  Seminars Committee, Chair  MDTC, Board member  Director of Confocal Microscope facility

Faculty:  Internal grant reviewer for MIMM Faculty of Medicine, CIHR project grant applications

Other:  Ad-hoc reviewer for the following journals: FEBS letters, Frontiers in Immunology, Respiratory Research, BMC biology, LoS Pathogens, PloS One, Journal of Immunology Research, Multiple Sclerosis, Microbes and infection, Journal of Leukocyte Biology, Clinical and Experimental Allergy, Respiratory Research  Reviewer NSERC Discovery Grant Competition  Reviewer CIHR Foundation Grant Competition, Stage 1  Reviewer NSERC-Research Tools and Instruments Grants Program (RTI)  President and organizer of 2016 Montreal Immunology Meetings Symposium: “Host-‐‐Microbe Interactions”, CR-CHUM, Montreal, Quebec, November 7, 2016; 200 participants, $15K budget  Canadian Society for Immunology, member  American Association for the Advancement of Science, member  American Association of Immunologists, member  Society for Mucosal Immunology  Public Education: Panel member and speaker for McGill Students for Vaccination Education and Awareness Week (November 22, 2016) Department of Microbiology and Immunology: 2016 Annual Report

Krawczyk, Connie

Department:  GCRC and PHGY Research Days Committee Judge  GCRC Associate Members Committee Member  MIMM Undergraduate committee Member  MIMM Career Day Organizer

Faculty:  FoM internal fellowships review committee Panel member/Reviewer  Internal reviewer of grants for faculty members Reviewer  LSC Flow Cytometry Committee Member

University:  McGill IgM Organizer (Immunology Group Meeting that brings together 20 labs from 3 McGill departments and 2 labs from UdeM)

Other:  Adhoc reviewer for Journals including Immunity, Cell Metabolism, Cell Reports, Fronteirs Immunology  MICRTP (GCRC Training Program Fellowships): Fellowship reviewer  McGill Internal FoM fellowships (PGAC), reviewer  Ontario Research Fund, reviewer  MITACS Accelerate Program, reviewer  CFI Leader’s Opportunity Fund, reviewer  Fall CIHR Project Scheme, reviewer  NSERC discovery Grants, reviewer  Canadian Cancer Immunotherapy Consortium June, Halifax N.S.: Participated as conference organizer as coordinator of knowledge dissemination and outreach; reviewed abstracts for travel awards, and for speakers chosen from abstracts and communication/collaborative leader between CCSRI and BIOCANRx  PRO-DEAN - Joceline ANDERSEN, Department of History & Communication Studies.

Le Moual, Herve

Department:  Chair of the Core Facilities Committee  Director of the Microbiome and Disease Tolerance Centre (MDTC)

Department of Microbiology and Immunology: 2016 Annual Report

University:  Member of the University Tenure Committee for Recruitment, September 1, 2014 to August 31, 2017; 14 dossiers in 2016.  Faculty of Science Undergraduate Research Conference (URC), McGill University, October 2016. Judge and Departmental coordinator.

Other:  FRQS, Membre du comité d’évaluation des chercheurs boursiers Junior II, 2015 - 2016.  Member of the editorial board of the journal Oral Diseases, Wiley (Dentistry).  Reviewer of the following Journals: - Oral Diseases, 8 manuscripts, 2016. - BMC Microbiology, 1 manuscript, May 2016. - BMC Research Note, 1 manuscript, July 2016. - Scientific Reports, 1 manuscript, July 2016. - Scientific Reports, 1 manuscript, October 2016. - Scientific Reports, 1 manuscript, November 2016.  Chair, Infection and Immunity section, Canadian Society for Microbiologists (CSM), Toronto, ON, June 15-18 2016. Selection of speakers and judge on the poster competition.

Madrenas, Joaquin

Department:  Department Chair (until October 01)  Chair, Recruitment and Selection Committee  Chair, Departmental Promotion and Tenure Committee  Chair, Merit Evaluation Committee

University:  Vice-Chair, Staff Grievances and Disciplinary Committee  Provost Research Lab Infrastructure Working Group  Principal's Task Force on Developing an Academic Vision and Mission for the Potential Acquisition of the Royal Victoria Hospital Site

Marczynski, Greg

Department:  Graduate Program committee, member  Core facilities committee, member

Faculty:  Academic Committee, Faculty of Science, member

Department of Microbiology and Immunology: 2016 Annual Report

Other:  Review editor: - Frontiers in Microbiology, 3 Manuscript Reviews - Molecular Microbiology, Manuscript Review - Nature Communications, Manuscript Review  Swiss National Science Foundation: Grant Reviewer  NSERC: Grant Reviewer  Science Festival judge, Canada-Wide Science Festival, 15-16 May 2016 at McGill.  Represented MIMM at Open house Redpath Hall, 30 Nov 2016.  Supervised Navid Zuberi (high school student) for his Science Fair Project. (Navid won the silver medal for at the Montreal Regional Science and Technology Fair)

Matlashewski, Greg

Department:  Department equipment committee, member  Department tenure and promotions Committee, member  Department undergraduate student committee, member  Chairs Advisory Committee, member (until September 2016, Chair’s departure)

University:  Executive Committee Member, McGill Global Health Program.  Faculty of Medicine Search Committee to recruit a new Department Chair.

Other:  Research priorities for the elimination of visceral leishmaniasis. World Health Organization. March 2016. Advisory Member.  Research priorities for the elimination of visceral leishmaniasis in India. Indian Council of Medical Research 2016. Advisory Member.  Reviewer for manuscrips including Science, PloS journals, Vaccine, Euk. Cell.  Organizing Committee: World Leishmaniasis Meeting (WorldLeish, 2017), to be held in Toledo, Spain, May 2017.  United Nations sponsored workshop on Leishmaniasis for new investigators from endemic countries. Trieste, Italy. October 24-26, 2016. Workshop Organizer and lecturer.

Maurice, Corinne

Department:  Seminar Committee, member  MDTC Board, Microbiome and Disease Tolerance Centre, member  Graduate and Postgraduate Education Committee, member  Honour’s Undergraduate Research Day, evaluator Department of Microbiology and Immunology: 2016 Annual Report

University:  FRQNT New University Researchers Information Session, Office for Sponsored Research, Speaker

Other:  Reviewer of the following journals: Journal of animal ecology, Gut Microbes, SpringerPlus, Cell Systems, Cell, The ISME Journal, Anaerobes, Journal of Infectious Diseases, Scientific Reports, BMC Microbiology, PLOS One  External Reviewer of NSERC Discovery Grant, Tier 2 Canada Research Chair, Antimicrobial Resistance (US Army Research Department), BAA Military Operational Medicine (US Army Research Department  International Society for Viruses of Microorganisms, member  Pro-Dean: Zaid Al-Ghouleh « Development of Green concrete from industrial wastes and carbon dioxide », 9 November 2015, Departement of Civil Engineering and Applied Mechanics, McGill University.  Canadian Society of Gastroenterology, member  International Society for Microbial Ecology, member  Canadian Society of Microbiologists, faculty representative and member  International Society for Viruses of Microorganisms, member  Canada-Wide Science Fair, judge

Murgita, Robert

Department:  Graduate and Post-Graduate Education Committee, member  Core Facilities Committee, member  Departmental Tenure and Promotions Committee, alternate member  MIMM Undergraduate Advisor  Undergraduate Committee, member  Seminars Committee, member

Faculty:  Faculty of Medicine – Biomedical Curriculum Committee, member

University:  Senate Committee on Libraries, member  Medical Scientist – McGill University Health Centre (MUHC), Department of Microbiology, 2007- present  Council of Physicians, Dentists, and Pharmacist (CPDP) Member – McGill University Health Centre (MUHC), 2011-present

Other:  External Reviewer for PLOS One, Journal of Immunology and Clinical Research  Senate Committee on Libraries (member) Department of Microbiology and Immunology: 2016 Annual Report

 Member of the editorial board of the following journals: - Journal of Immunology and Clinical research - Journal of Microbiological Methods - Journal of Autoimmunity and Cell Responses - Journal of PLOS ONE

Olivier, Martin

Department:  Graduate Student Committee, member  Reappointment and Tenure Committee, member  Undergrad Student Committee, member  Graduate Student Admission Committee (Experimental Medicine), member  Graduate students Academic Advisor (Experimental Medicine)  Executive Committee (Experimental Medicine), member

University:  Member of the McGill University Laboratory Safety Committee (ULSC), Faculty of Medicine Representative  NSERC Postgraduate Selection Committee, member

Other:  Dr. Jean-François Cailhier, CHUM, Université de Montréal (2012-2016), mentor  Dr. Martin Richer, Department of Microbiology and Immunology, McGill University (2014- Present), mentor  Associate Editor, PLoS Pathogens  Associate Editor, PLoS Neglected Tropical Diseases  Society Member of Canadian Society for Immunology, Society for Leukocyte Biology, European Macrophage Society, Council of Physicians, Dentists and Pharmacist (CPDP, International Society for Extracellular Vesicles (ISEV)  Manuscript reviews: Scientific Reports, BMC Research Notes, Malaria Journal, PLOS Pathogens, PLOS NTD, Cell host and Microbes  Internal grant reviewer (RI-MUHC): Merck Sharp & Dohme, bridge funding, Studentship/Fellowship Competition  External reviewer: CIHR Foundation Scheme Stage 2 Committee, CIHR College of Reviewers (member), CIHR International Peer Review expert, Swiss National Foundation, Welcome Trust, INSERM, Polish Academy of Sciences  IRIC PIs Performance Evaluation Committee, Université de Montreal, member  Centre for Host Parasite Interaction (CHPI) FQRNT Provincial Network: Member of the Bridging Fund Committee for grad and postdoc trainees.  CONGRESS ORGANIZATION: President/Chair, ICOPA XV (2022); Coordinator of Evaluation Committee, ACFAS 2017 Department of Microbiology and Immunology: 2016 Annual Report

Piccirillo, Ciriaco

Department:  Departmental Undergraduate Committee (Chair 2014-2016)  MIMM-314 Redevelopment Committee  Advisory Council to the Chair (MIMM)  Merit Committee, member  Departmental Tenure and Promotions Committee, member  McGill Disease Tolerance Centre (MDTC), associate member  Organizing of MIMM Kiosque at McGill Homing Coming (October 2016)

University:  B.Sc./M.Sc. degree exploratory Faculty committee (McGill)  McGill International TB Centre, associate member  Montreal Diabetes Research Center (MDRC), full member  McGill-MUHC FOCIS Centre of Excellence, Director  Associate member: McGill Disease Tolerance Centre (MDTC)  Associate member: McGill International TB Centre  Full member: Montreal Diabetes Research Center (MDRC)  Director, MUHC RI Immunophenotyping Platform.  CIHR Human Immunology Network (CHIN), Director of Montreal Node (McGill)  Chair, Platform Advisory Committee for the Immunophenotyping Platform (RI-MUHC)  Technology platforms oversight committee for MUHC Research Institute  Steering committee: Program in Infectious Diseases and Immunity in Global Health (IDIGH) (RI- MUHC)  Steering committee: Program in Childhood health and Human Development (RIMUHC)  Leader, division of Translational Immunology in the IDIGH Program, MUHC Research Institute  Co-Chair, Canadian Human Immunophenotying Consortium (CHIC)  Director, MUHC/McGill Centre of Excellence in Translational Immunology (CETI)

Other:  Academic Editor, PLoSONE  Editorial Board, World Journal of Diabetes  Editorial Board, Frontiers in Immunology  Editorial Board, International Trends in Immunology  Editorial Board, American Journal of Clinical and Experimental immunology  Member of CSI, AAI, IDS and FOCIS societies  Reviewer for Diabetes, Frontiers, The Journal of Immunology, Journal of Experimental Medicine, Immunity, Blood, Nature Medicine and Nature Immunology  Elected Chair (2013-2016): Community of Practice for FOCIS  Chair, Membership committee for FOCIS (2014-2016) Department of Microbiology and Immunology: 2016 Annual Report

 Board of Directors (2014-2016) FOCIS  Appointed Chair of Abstracts group in Programme Committee for 2015 and 2016 FOCIS annual meetings  Establishment of the Teaching Research Excellence to Girls (TREG) Program at Sacred Heart High School, destined to raise awareness of high-achieving girls to the importance biomedical research in society.  Keynote Speaker at 2016 Golf Tournament to fundraise for T1D Research.  Securing substantial donation from Montreal-based donor for T1D research and clinical trial at MUHC Research Institute  Organization of a CHIN-Canadian Human Immunophenotyping Consortium (CHIC) Workshop in Human Immunophenotyping (Fall 2016)

Richer, Martin

Department:  Graduate and Post-graduate Education Committee, Department of Microbiology and Immunology, McGill University, Member  Core Facilities committee, Microbiology and Immunology (Sep 2016-present), member  Departmental Safety Committee, Microbiology and Immunology (Sep 2016-present), member  Faculty of Medicine Safety Committee, Faculty of Medicine (Sep 2016-present), member  Chair search committee for Microbiology and Immunology, Faculty of Medicine (Nov 2016-  present), member

University:  Pro-Dean: Zhen Cao (November 9th 2015, School of Computer Science, Verbrugge Lab, McGill)

Other:  MDTC board member  Reviewer for Frontier in Cellular and Infection Microbiology, Journal of Virology, Oncoimmunology, Frontiers in Immunology, Frontiers in Microbiology, IRCM scholarships, Canadian Cancer Society Research Institute Travel Awards, 85e congress de l’ACFAS  Review Panel CFI John R. Evans Leaders Fund, FRQS/CFI (since Jan. 2016)  Editorial board membership: Frontiers in Cellular and Infection Microbiology  Member of the Canadian Society for Immunology

Sagan, Selena

Department:  MIMM Seminar Committee (Jan – Aug 2016)  MIMM Undergraduate Committee (Sep 2016 – Present)  MIMM Merit Committee (Sep 2016 – Present)  MIMM Gala Committee (Jan 2016 – Present) Department of Microbiology and Immunology: 2016 Annual Report

 MIMM Interim Chair Committee (Ad hoc, 2016)Departmental Gala Committee, Member, Department of Microbiology Immunology, McGill University, Sep 2014 - Present

Faculty:  Faculty Council, Faculty of Medicine, Member (Jan 2016 – Dec 2018)

Other:  Grant Review, Project Scheme Live Pilot, CIHR, Spring 2016 Competition (14)  Grant Review, Programmes Transversaux de Recherche – PTR, Institut Pasteur, External Reviewer (1)  Conference Abstract Review Activities (external): 6th Canadian Symposium on Hepatitis C virus (10)  Manuscript Review Activities (external): Virology (3), J Virol (2), Scientific Reports (2), PNAS (1), Viruses (1), mBio (1), Gastroenterology (1), J Biomaterials (1), Cell Death Diff (1), McGill Undergraduate Research Journal (1).  5th Canadian Symposium on Hepatitis C Virus: “We’re not done yet: Remaining Challenges in HCV”, Montreal, QC, Canada (Feb 26th, 2016) - Co-Chair, meeting co-organizer (w/Marina Klein, McGill University) - CIHR Meeting and Dissemination Grant, PI, Awarded, Jan 2016 – Dec 2016 - Abstract Review - Meeting Summary (published in Can J Gastro 2016)  Internal Review, CIHR Project Scheme Grant Application, Lady Davis (1)  Internal review, CIHR Project Scheme Grant Applications, McGill University (2)  Editorial Board Member, Virology (Elsevier), Nov 2015 - Present  National CIHR Hepatitis C Network – CanHepC, Member (Education Committee, Basic Science Core Advisor)  American Society for Virology (ASV), Sep 2014 – Present  Canadian Association for the Study of the Liver (CASL), Mar 2014 – Present  Interview, McGill Tribune, Zika virus outbreak, Knowledge Translation activity  Interview, McGill Reporter, Mobile-based clickers in the classroom, Knowledge Translation activity

Sheppard, Don

Department, Faculty and University:  Division Director, Infectious Diseases  Microbiology/Infectious Diseases Resident Program Committee  Microbiology/Infectious Diseases Resident Research Committee  Department of Medicine Research Committee  Department of Medicine Manpower Committee  Department of Medicine Ad Hoc Advisory Committee

Hospital:  Division Director, Infectious Diseases Department of Microbiology and Immunology: 2016 Annual Report

 Theme leader, Infection and Immunity in Global Health Program, MUHC Research Institute: 4h

External:  Chair, Awards Committee, Association of Medical Microbiology and Infectious Diseases of Canada  Scientific Organizing Committees - International Society for Human and Animal Mycology - Advances against Aspergillosis  MUHC-RI: Internal reviews for CIHR Foundation (2); Project (4); and Bridge funding (2)  External reviewer Wellcome trust/DBT India Alliance  External reviewer France National Research Agency (ANR)  CIHR Project Reviewer  Guest Editor, Medical Mycology (Special Issue) - 7 manuscripts  Associate Editor, PLoS Pathogens (11 manuscripts)  Manuscript reviews (12): JCI (1), Bioresources (1), Mbio (2), Lancet ID (1), Cellular Microbiology (1), ClinInfect Dis (1), Infection and Immunity (1), Fundamental Pharmacology (1), Plos Pathogens (1), Future Medicinal Chemistry (1), Microbiology and Molecular Biology Reviews (1)

Stevenson, Mary

Department:  Departmental Tenure and Promotion Review Committee, Member, 2015-present  Departmental Academic Merit Review Committee, Member, 2015-present

Faculty:  Member, Departmental Representative, Social Accountability Committee, Faculty of Medicine, McGill University, 2015-present  Member, Review Committee, NSERC Studentship Competition, Faculty of Medicine, 2016

University:  Pro-Dean for the PhD Thesis Defense of Ms. Anne-Marie Ritzema, Department of Educational and Counseling Psychology, Faculty of Education, June 2015  Pro-Dean for the PhD Thesis Defense of Ms. Shabnam Hamidi, Integrated Program in Neuroscience, Department of Medicine, Faculty of Medicine, December 2015

Other:  Reviewer: PloS Pathogens, Journal of Immunology, Infection and Immunity, PLoS One, Scientific Reports, and Malaria Journal  Associate Editor, PLoS Pathogens, Expertise: malaria immunology, malaria pathogenesis, helminth-induced immunomodulation  Member, Travel Awards Committee, American Society of Tropical Medicine and Hygiene  Chair, Finance Committee, 20th Annual Woods Hole Immunoparasitology Meeting (WHIP 2016)  Member, F1000, Infection and Immunity Section

Department of Microbiology and Immunology: 2016 Annual Report

Trottier, Claire

Department:  Member of the Graduate Committee (2015-present)  Member of the Undergraduate Committee (2013-present) Faculty  Member of the Scholarship, Critical Thinking and Knowledge Translation Theme Subcommittee, Faculty of Medicine (2016-present)  Member of Faculty Development working group for basic science, Faculty of Medicine (2015- 2016)

University  Member of the TLS Writing Group (2016-present)  Member of the Centre for Medical Education (2011-present)

Other:  Research Residency, Biology Scholars Program, American Society for Microbiology (Spring 2015- Fall 2016): A selective 18-month program designed to empower biologists to be leaders in science education, build capacity in biology education research, and catalyze sustained undergraduate education reform.

Wainberg, Mark

Department:  Departmental Tenure and Promotions Committee – member

University:  McGill Aids Centre, Director  Internal Reviewer of grant applications at LDI

Other:  Co-Editor-in-Chief, Retrovirology  Co-Editor-in-Chief, Journal of the International AIDS Society  Board of Scientific Counselors, National Cancer Institute, NIH, Member  Scientific Committee – Canadian Foundation for AIDS Research, Member, Vice-Chair

Department of Microbiology and Immunology: 2016 Annual Report

Section V Consulting Activities Department of Microbiology and Immunology: 2016 Annual Report

11. Consulting Activities

Number of Days Private Public Other, including off-site teaching Faculty Member Name of Organization Sector Sector Total (please explain) Consulting Consulting ARCHAMBAULT, Antiva Biosciences 5 5 Jacques KRAWCZYK, Connie EnGene X Pro Bono MAURICE, Corinne Seres Therapeutics 2 2 (personnel training) 2 Janssen Pharmaceutical 7 7 AIHS 4 4 JDRF 5 5 CIHR 9 9 PICCIRILLO, Ciro NIH 12 12 Austrian Science Fund (ASF/FWF) 2 2 Broad Foundation 4 4 Agence Nationale de la Recherche- France 3 3 Merck Global Advisory Board 3 3 SHEPPARD, Donald 9 days teaching as faculty in residence (5 Woods Hole Molecular Mycology Course 5 workdays)

Department of Microbiology and Immunology: 2016 Annual Report

12. Appendices

Department of Microbiology and Immunology: 2016 Annual Report

TABLE 1. NUMBER OF UNDERGRADUATE STUDENTS TAUGHT IN WINTER 2016/ SUMMER 2016/ FALL 2016

Semesters Winter Summer Fall Total Undergraduate Course Enrolment 816 5 839 1660 Faculty of Science Microbiology and Immunology Students: 260 293 I.H.I. Students: 29 35

Number of Non MIMM students taught in MIMM courses BSc. 324 144 468 Other 16 19 35 No degree/ exchange/ special/ Quebec IUT 15 19 34 Total 355 182 537

TABLE 2. FULL TIME EQUIVALENT (FTE) OF UNDERGRADUATE STUDENTS IN COURSES BY THE DEPT. DURING THE PAST FIVE YEARS

Winter Fall Winter Fall Winter Summer Fall Winter Fall Winter Fall 2012 2012 2013 2013 2014 2014 2014 2015 2015 2016 2016 87 86 96 77 87 0.4 75 86 78 86 74

Department of Microbiology and Immunology: 2016 Annual Report

TABLE 3. ENROLMENT IN UNDERGRADUATE PROGRAMS IN MICROBIOLOGY & IMMUNOLOGY, WINTER 2016, FALL 2016

Winter 2016 Fall 2016

U1 U2 U3 Total U1 U2 U3 Total Majors 102 79 53 234 105 89 60 254 Honours 19 19 29 29 Core Sci. Comp 1 2 4 7 3 7 10 (Liberal) 260 293

TABLE 4. UNDERGRADUATE STUDENTS ENROLLED IN DEPT. DURING THE PAST FIVE YEARS

Winter 2012 Fall 2012 Winter 2013 Fall 2013 Winter 2014 Fall 2014 Winter 2015 Fall 2015 Winter 2016 Fall 2016 289 290 276 280 273* 279* 273* 310* 273* 328* * includes IHI students

Department of Microbiology and Immunology: 2016 Annual Report

TABLE 5. UNDERGRADUATE ENROLMENT AND COURSE FTE'S - WINTER 2016/SUMMER 2016/FALL 2016

Winter 2016 Course Title Credits Enrolment Credits times enrol. FTE MIMM 214 Intro. Immunology 3 328 984 33 MIMM 314 Immunology 3 112 336 11 MIMM 385 Micro. & Imm. Lab 3 83 249 78 MIMM 387 Business of Science 3 141 423 14 MIMM 396 Micro. Research Project 0 0 0 0 MIMM 397 Imm. Research Project 3 3 9 0 MIMM 413 Parasitology 3 57 171 6 MIMM 466 Viral Pathogenesis 3 60 180 6 MIMM 499 Library Research Project Micro. 1 1 1 0 MIMM 501D2 Honours Imm Res Project 6 11 66 1 MIMM 502D2 Honours Micro Res Project 6 8 48 1.6 MIMM 509 Inflammatory Processes 3 12 36 1 37 816 2503 86

Summer 2016 Course Title Credits Enrolment Credits times enrol. FTE MIMM 396 Micro. Research Project 3 2 6 0 MIMM 397 Immuno. Research Project 3 3 9 0 6 5 15 0

Fall 2016 Course Title Credits Enrolment Credits times enrol. FTE MIMM 211 Intro. Microbiology 3 227 681 23 MIMM 212 Microbiology Lab 3 119 357 12 MIMM 323 Microbial Physiology 3 103 309 10 MIMM 324 Fund. Virology 3 115 345 12 MIMM 384 Micro. & Imm. Lab 3 99 297 10 MIMM 396 Micro. Research Project 3 1 3 1 MIMM 397 Imm. Research Project 3 5 15 6 MIMM 414 Advanced Immunology 3 64 180 5 MIMM 465 Bacterial Pathogenesis 3 78 198 6 MIMM 499 Library Research Project Imm. 1 2 2 0 MIMM 501D1 Honours Imm Res Project 6 15 90 4 MIMM 502D1 Honours Micro Res Project 6 11 66 3 40 839 2543 74 Department of Microbiology and Immunology: 2016 Annual Report

TABLE 6. STUDENT EVALUATION OF UNDERGRADUATE COURSES IN MICROBIOLOGY & IMMUNOLOGY WINTER 2016 AND FALL 2016

number of evaluation number of evaluation course # completed (1=poor course # completed (1=poor evaluations 5=excellent) evaluations 5=excellent) Winter 2016 Fall 2016 60 out of MIMM 214 90 out of 322 4.5 MIMM 211 4.55 226 MIMM 314 57 out of 112 4.3 MIMM 212 57 out of 118 4.7 29 out of MIMM 385 23 out of 83 4.1 MIMM 323 3.45 101 35 out of MIMM 387 135 out of 141 4.05 MIMM 324 4.05 114 MIMM 413 16 out of 57 4.45 MIMM 384 39 out of 97 3 MIMM 466 16 out of 60 3.45 MIMM 414 20 out of 64 4.4 MIMM 501/502D2 12 out of 19 4.4 MIMM 465 16 out of 78 4.35 MIMM 509 10 out of 12 4.7 average 4.27 average 4.071

Question 1 - Overall, this is an excellent course (question 1 & 2 average). Question 2 - Overall, I learned a great deal from this course (question 1 & 2 average).

TABLE 7. UNDERGRADUATE STUDENTS GRADUATIONS WINTER 2016, SPRING 2016, FALL 2016

Winter 2016 Spring 2016 Fall 2016

Liberal 1 Liberal 1 Liberal

Honours 0 Honours 16 Honours

Majors 6 Majors 32 Majors 3

IHI Honours 0 IHI 9 IHI 0 TOTAL 7 58 3 68

Department of Microbiology and Immunology: 2016 Annual Report

TABLE 8. UNDERGRADUATES APPLIED/REGISTERED TO THE B.SC./M.SC. FAST TRACK PROGRAM Spring 2015 Spring 2016 Applied Registered Applied Registered 6 3 2 2

TABLE 9. TOTAL GRADUATE DEGREES GRANTED OVER THE PAST FIVE YEARS Winter 2016 Summer 2016 Fall 2016 Registered Graduated Registered Graduated Registered Graduated M.Sc. 27 2 28 3 23 1 Ph.D. 35 0 37 1 43 1 TOTAL 62 2 65 4 66 2

Winter 2015 Summer 2015 Fall 2015 Registered Graduated Registered Graduated Registered Graduated M.Sc. 31 0 27 4 30 3 Ph.D. 39 2 37 3 35 5 TOTAL 70 2 64 7 65 8

Winter 2014 Summer 2014 Fall 2014 Registered Graduated Registered Graduated Registered Graduated M.Sc. 25 2 27 1 33 3 Ph.D. 37 4 36 1 38 1 TOTAL 63 6 63 2 71 4

Winter 2013 Summer 2013 Fall 2013 Registered Graduated Registered Graduated Registered Graduated M.Sc. 20 4 21 0 27 4 Ph.D. 43 3 41 2 38 8 TOTAL 63 7 62 2 65 12

Winter 2012 Summer 2012 Fall 2012 Registered Graduated Registered Graduated Registered Graduated M.Sc. 25 6 22 4 22 6 Ph.D. 46 1 45 3 44 4 TOTAL 71 7 67 7 66 10

Department of Microbiology and Immunology: 2016 Annual Report

TABLE 10 . GRADUATE STUDENT ENROLLMENT & POSTDOCS 2011 2012 2013 2014 2015 2016 Graduate Students 74 68 63 80 66 69

Number of New 22 15 20 26 16 30 Graduate Students

Average CGPA of 3.76 3.53 3.48 3.59 3.61 3.76 Incoming Students

Number of Postdocs 9 16 12 14

TABLE 11 . GRADUATE STUDENTS & POSTDOCS over the past five years

2012 2013 2014 2015 2016 Number of New 15 20 26 16 30 Graduate Students Average CGPA of 3.53 3.48 3.59 3.61 3.76 Incoming Students

Number of Postdocs 9 16 12 14 Department of Microbiology and Immunology: 2016 Annual Report TABLE 12. Funding of graduate students by source (2016) A. Departmental Awards Value Max Binz Fellowship $20,666.00 FC Harrison Award $49,702.00 W. Yaphe Award $700.00 Rozanis Fellowship $23,229.00 The Wares Family Postodoc Award $10,000.00 Graduate Student Research Day $250.00 TOTAL $104,547.00 B. Faculty of Medicine Allocation Value Graduate Excellence Fellowship (GEF's) $155,000.00 Meakins Christie Fellowship $20,000.00 The Great Travel Awards $4,500.00 Internal Studentship Awards $18,249.00 TOTAL $197,749.00 C. Internal Funding Value Student Stipends (Department) $656,860.01 Differential Fee Waiver $14,366.00 Teaching Assistantships $51,740.24 Invigilation McGill University $624.19 TOTAL $723,590.44 D. External Fellowships Value NSERC/Research Assistantship $52,499.32 NCRTP-HepC $8,500.00 CIHR Studentship Award $146,749.99 China Scholarship Council $12,800.00 Burroughs Welcome Fund $21,129.00 FRQS $80,000.00 FQRS $15,000.00 MITACS $20,000.00 CNPq (Brazil) $23,000.00 Brazil Ministry of Science $23,000.00 Saudi Arabia Government $30,000.00 TOTAL $432,678.31 GRAND TOTAL $1,458,564.75