Performance Report 2014

Department of Pathophysiology & Allergy Research

Center of Pathophysiology, Infectiology and Immunology

Medical University Vienna

Coordinated by:

Marion Sack Content Page

Introduction 3

Organigram 6

Personnel 9

Impulsseminare 11

1. Detailed Reports of Divisions 13

1.1. Division for Comparative Immunology and Oncology 13

1.2. Division for Cellular and Molecular Pathophysiology 39

1.3. Division for Immunopathology 65

1.4. Division for Medical Biotechnology 89

1.5. Division for Allergy Research 109

Rooms 119

Social Events 121

Science knows no country because it is the light that illuminates the world.

Louis Pasteur ______

As head of the Institute of Pathophysiology and Allergy Research (IPA) I am proud to introduce this detailed overview on our scientific and academic achievements by mentioning that 2014 has been a successful year! I would like to continue this performance report by announcing that the budget situation has improve and that funding of research has increased, however, this is unfortunately not true. Nevertheless, despite the current situation of more and more restricted funding and a reduction of personnel the IPA has shown that it can rely on a very strong team. During the past year, we have continued to grow together, our team spirit has increased and the internal communication has improved. These developments led to a remarkable output in terms of science and academic teaching. I wish to express my sincere thanks to all IPA members who have contributed to our notable success! I also wish to express my sincere thanks to Univ. Prof. Hannes Stockinger, the head of the centre for Pathophysiology, Infection, and Immunology (CePII), for his continuous support and transparent policy. If we continue our exemplary internal and international teamwork, laudable commitment and a high level of identification with the major goals of the IPA and of the Medical University of Vienna we will easily combat the more strenuous times regarding financial support for research and personnel in the future. This will allow us to continue to perform excellent science and academic teaching in a cooperative atmosphere!

Barbara Bohle Head of the IPA

General overview

Twenty highly active research groups at the IPA have worked successfully on both basic and translational aspects in cellular and molecular pathophysiology, immunopathology, comparative immunology, oncology, medical biotechnology and allergology. Their efforst resulted in numerous publications in peer-reviewed high-impact journals, research awards and many contributions to prestigious scientific national and international meetings were accomplished. A total sum of 235 impact factors was gained in 2014 which is higher than 2013! Figure 1 gives an overview on the development of the IPA´s impact factors in the past decade.

Figure 1

450

400

350

300

250 new calculation of IF 200

150

100 total sum of impact factors impact of sum total 50

0 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

2014 was also a very successful year in terms of recruiting third party funding and research grants. Congratulations to all project leaders who successfully run research projects funded by the Austrian Science Fund (FWF) and other funding agencies, e.g. the Österreichische Nationalbank, the medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien and the European Commission! The total sum of third party funding makes 95% of the IPA budget and 61% of our staff is paid by this money. This positive funding situation also reflects that the members of the IPA are highly active researchers and well embedded in the international fields of their expertise. The IPA is proud of several successful and long lasting collaborations with national and international research partners.

In addition to research, the IPA takes teaching and education very seriously. In 2014, a total of 114 Austrian and international bachelor, diploma and PhD students were educated. Figure 3 shows that the total numbers of diploma (white circles), PhD (black circles) and bachelor

4 students (black triangles). Several group leaders are involved in the three doctoral programs IAI, CCHD and MCCA funded by the FWF which also reflects the high quality of training of PhD students at the IPA.

The high commitment of the IPA’s members to teaching is reflected by the total numbers of semester hours of the members of the IPA held at the Medical University from 2004-2014 (Figure 2).

Figure 2 Figure 3

300 70

250 60

50 200

40 150 30

100

20 total number of students of number total

50 10 sum of semester hours at the MUV the at hours semester of sum 0 0 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Moreover, the IPA regularly held “Impulse Seminars” which can be regarded as advanced training for IPA members but also external guests. In these seminars the different group leaders at the IPA introduce and discuss their latest scientific achievements. Furthermore, members of the IPA are active in teaching and examining at other universities. Several IPA members also act as reviewers of external diploma and PhD theses, Habilitations, scientific manuscripts and research grants, and are active on editorial and advisory boards and on the boards of national and international research societies.

In summary, we are looking back at a very successful year! Our reference values were achieved by outstanding individual efforts, a strong team spirit and the great commitment of all IPA members. We are a strong and successful team and can be proud of that!

Performance Report 2014 Organigramm Organigram (December 2014)

Head: Barbara Bohle, PhD, Professor for Cellular Allergology Deputy Head: Peter Pietschmann, MD, Assoc. Professor

Department Secretary: Marion Sack Check point: Andreas Kunrath Student Secretary: Marion Krones (50%), Zorica Stanojevic (50%)

Division for Comparative Immunology and Oncology

Head: Erika Jensen-Jarolim, MD, Professor for Pathophysiology, Professor for Comparative Medicine Secretary: Nora Diallo Erika Bajna, CTA, 50% WG AllergoOncology: Head: Erika Jensen-Jarolim, MD, Professor Beatrix Pfanzagl, Ass. Professor Caroline Stremnitzer, PhD-Student Franziska Roth-Walter, PhD Jordakieva Galateja, PhD-Student Lukas Einhorn, PhD- Student Martina Muhr, Diploma Student Judit Fazekas, PhD- Student Irene Fürdös, Diploma Student Josef Singer, PhD-Student Stefanie Wagner, Diploma Student Helen Szöllösi, PhD-Student Cornelia Belik, Diploma Student Oida Kumiko, PhD-Student Sarah Meitz, Bacherlor Student Jelena Gotovina, PhD-Student Miroslawa Matz, Tech. Ass WG Tumor Pathology: Head: Enikö Kallay, PhD, Assoc. Professor Charlotte Gröschel, PhD-Student Abhishek Aggarwal, PhD-Student Irfete Fetahu, PhD-Student Teresa Manhardt, CTA Samawansha Tennakoon, PhD-Student Maria Elena Manfredini, Project manager WG Gastrointestinal Immunology: Head: Eva Untersmayr-Elsenhuber, MD, Assoc. Professor Katharina Beitl, Diploma Student Sarah Exenberger, Diploma Student Anna Ondracek, Diploma Student Cornelia Schultz, BMA

Division for Cellular and Molecular Pathophysiology

Head: Peter Pietschmann, MD, Assoc. Professor Secretary: Birgit Schwarz Erika Bajna, CTA, 50% WG Bone, Cartilage and conn. Tissue Research: Head: Peter Pietschmann, MD, Assoc. Professor Ursula Föger-Samwald, PhD-Student Robert Wakolbinger, PhD-Student Eduardo Maldonado-Gonzalez, PhD-Student Florian Körbler, Diploma-Student Adalbert Raimann, PhD-Student Christiane Lamm, Diploma-Student György Vekszler, PhD-Student Katharina Wahl, CTA WG Cell Biology: Head: Renate Fuchs, PhD, Assoc. Professor Haleh Ganjian, PhD-Student Julian Otto, Diploma Student Thomas Spanberger, Diploma Student Katharina Gelles, BMA

Performance Report 2014 Organigramm

WG Pathophysioloy of the Placenta: Head: Isabella Ellinger, PhD, Assoc, Professor Lukas Klameth, PhD-Student Arife Sener, Diploma Student Richard Liedauer, PhD-Student Martin Schaffhauser, Diploma Student Elisabeth Straka, PhD-Student Jost Kemper, Diploma-Student Wolfgang Seebacher, Diploma Student Martin Reiter, Diploma Student Christoph Jungwirth, Diploma Student Agnes Voss, Diploma Student Andreas Maier, Diploma Student WG Cellular Pathology and Pharmacokinetics: Head: Theresia Thalhammer, PhD, Assoc. Professor Rentsen Erdentetsetseg, PhD-Student Aida Larijani, Diploma Student Radu Rogojanu, PhD-Student Yasemin Durmaz, Diploma-Student Michaela Ganster, Diploma Student Branislava Eric, Diploma-Student Isabel Ackermann, Diploma Student Nora Geissler, Diploma Student Bolis Marian, Diploma Student Maidah Sheikh, Diploma Student Wenyi Zhang, Diploma Student WG Molecular System Biology and Pathophysiology Head: Diana Mechtcheriakova, PhD, Priv.-Doz. Anastasia Meshcheryakova, PhD-Student

Division for Immunopathology

Head: Rudolf Valenta, MD, Professor for Allergology Secretary: Doris Werjant Editorial Secretary: Sanna Lippert SFB-Secretary: Anna Guentcheva Milena Weber, CTA WG Molecular Immunopathology: Head: Rudolf Valenta, MD, Professor Birgit Linhart, PhD Cornelius Carolin, PhD-Student Christian Lupinek, MD Narayanan Meena Balakumari, PhD-Student Raffaela Campana, PhD Raphaela Freidl, PhD-Student Katarzyna Niespodziana, PhD Dzoro Sheron, PhD-Student Curin Mirela, PhD, Pia Gattinger, PhD-Student Wei-Chen Kuan, PhD Borochova Kristina, PhD-Student Cabauattan Clarissa, PhD Kiss Renata, CTA Gallerano Daniela, PhD-Student WG Immunotechnology: Head: Susanne Vrtala, PhD, Assoc. Professor Irene Mittermann, PhD Huey-Jy Huang, PhD-Student Sandra Pahr, PhD Azahara Rodríguez-Domínguez, PhD-Student Yvonne Resch, PhD-Student WG Immunochemistry: Head: Margarete Focke-Tejkl, PhD, Assoc. Professor Katharina Marth, MD Yulia Dorofeeva, PhD-Student Mary Kodydek, PhD-Student WG Antibody Research Head: Sabine Flicker, PhD, Priv.-Doz. Elisabeth Gadermaier, PhD Nazanin Najafi, PhD-Student Christoph Madritsch, PhD-Student

Performance Report 2014 Organigramm

Division for Medical Biotechnology

Head: Heimo Breiteneder, PhD, Professor for Medical Biotechnology Secretary: Julia Krüger Nina Lengger, BMA WG Biotechnology & Biochemical Diagnostics: Head: Heimo Breiteneder, PhD, Professor Merima Bublin, PhD, Priv.Doz. Daniele Pucciarelli, PhD-Student Christine Hafner, MD Palladino Chiara, PhD-Student Barbara Gepp, PhD-Student Tanja Kalic, PhD-Student Tscheppe Angelika, PhD-Student WG Molecular Allergology: Head: Karin Hoffmann-Sommergruber, PhD, Assoc. Professor Kazem Ashjaei, PhD-Student Magdolna Vermes, ARat Pawel Dubiela, PhD-Student Piotr Humeniuk, PhD-Student WG Biochemistry and Bioinformatics: Head: Christian Radauer, PhD, Assoc. Professor WG Molecular Research in Traditional Chinese Medicine: Head: Yan Ma, PhD, Assoc. Professor Administration TCM: Ulrike Loidl He Shan, PhD-Student Mao Xinjun, Diploma Student Wang Xiaoxia, Diploma Student Duan Heying, Diploma Student Feder Astrid, Diploma Student

Division for Experimental Allergology

Head: Barbara Bohle, PhD, Professor for Cellular Allergology Secretary: Dorothea Angelides CD-Laboratory Secretary: Bana Haddad Birgit Nagl, BMA WG Allergy Research: Head: Barbara Bohle, PhD, Professor Claudia Kitzmüller, PhD Dagmar Kollmann, PhD-Student Stephan Deifl, PhD-Student Dominika Polak, PhD-Student Nora Zulehner, PhD-Student Gabriela Sanchez-Acosta, PhD-Student Dagmar Beatrice Werner, PhD-Student Sandra Faustmann, BMA WG Cellular Allergology: Head: Beatrice Jahn-Schmid, PhD, Priv.-Doz. Nazanin Samadi, PhD-Student Simone Böll, Diploma Student Manuel Reithofer, PhD-Student

Facility Services and Animal Keeping:

Katharina Reinberger Brigitte Schwarz Andrea Vlasaty

Performance Report 2014 Personnel ______a) Personnel of IPA (between January and December 2014)1

Personnel (p.) 01.01.2014 31.12.2014 MUW total female total female Univ.Prof. (full professors) RV, EJJ, BB, HB 4.00 2.00 RV, EJJ, BB, HB 4.00 2.00 Ao.Univ.Prof (Assoc.Prof) IE, RF, PP, TT, CR 5.00 4.00 IE, RF, PP, TT, CR 5.00 4.00 Univ./Priv.Doz. (Assoc.Prof) EUE,BJS,MFT 7.00 7.00 EUE,BJS,MFT 7.00 7.00 KHS,EK,SV,YM KHS,EK,SV,YM Assistant professors BP, BL, 2.00 2.00 BP,BL 2.00 2.00 Technical personnel NL,LG,TM,MM,MV, 9.00 8.00 NL,KG,TM,MM,MV, 9.00 9.00 KW,BN,MW, KW,BN,MW, EB EB Administrative personnel MS, AK, KJ, JK, 9.00 8.00 MS, AK, ND, JK, 9.00 8.00 DW, DA, BS, MK, DW, DA, BS, MK, BH ZS Supportive personnel AV, KR, BS 3.00 3.00 AV, KR, BS 3.00 3.00 39.00 34.00 39.00 35.00 Third party funded p. Scientific personnel Univ.Doz. 4.00 4.00 4.00 4.00 (Assoc.Prof) SF, DM, MB, IPS PostDoc 18.00 15.00 18.00 15.00 Doctoral students2 38.00 31.00 39.00 31.00 Technical personnel BMA 2.00 2.00 2.00 2.00 CTA 2.00 2.00 2.00 2.00 Administrative personnel BH, SL, AG 3.00 3.00 BH, BK, AG 3.00 3.00 Project employees MEM, UFS , LL 3.00 3.00 MEM, UFS , UL 3.00 3.00 Diploma students (FB3) 7.00 7.00 6.00 6.00 77.00 67.00 77.00 66.00

Other scientific Doctoral students 3.00 2.00 4.00 2.00 coworkers Diploma students 18.00 14.00 17.00 13.00 Student 3.00 1.00 2.00 1.00 apprentices 24.00 17.00 23.00 16.00 MUW personnel total 140.00 118.00 139.00 117.00

At the end of 2014 27,86% of the entire personnel was MUV-paid personnel. Of all IPA-employees 84.17% were female.

1 in full time equivalents “FTE” 40 h = 1 FTE 2 due to novel rules by FWF PhD students are employed 75 % FTE to be able to spend time for education 3 FB: Forschungsbeihilfe: defined financial support 9

Performance Report 2014 Impulsseminare ______

Continuous education of staff

Among the activities in the field of continuous education of the members of the Department in 2014 five “impulse seminars” were held. In these seminars, research group leaders present and discuss recent results from their projects. The seminars were very well attended and significantly promoted communication and active discussion among the members of the IPA. The “impulse seminars” are recognized as continuous medical education by the Austrian Chamber of Physicians. In 2014 the following topics were covered:

07.03.2014 Christian Radauer Cross-reactive allergens: from identification of epitopes to clinical relevance 04.04.2014 Theresia Thalhammer Transport proteins from the OATP/SLC0-family: A novel approach for cancer therapy 09.05.2014 Eva Untersmayr-Elsenhuber Update on food allergies: from allergen structure to novel mechanisms 03.10.2014 Barbara Bohle What makes a protein allergenic? Two examples giving possible answers 14.11.2014 Susanne Vrtala Recombinant mite allergens for diagnosis and immunotherapy

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

1. Detailed Reports of Divisions

1.1 Division for Comparative Immunology and Oncology Head: Erika Jensen-Jarolim, MD, Professor

1. Publications4 IF Number Top/Std/Subst Erika Jensen-Jarolim 29.956 11 9 Top, 2 St Enikö Kállay 17.154 4 1 Top, 3 St Isabella Pali-Schoell maternity leave maternity leave xxTop, xxSt Eva Untersmayr-E. 6.700 2 2Top Division-Sum 53.103 17 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Erika Jensen-Jarolim 2 4 8 Enikö Kállay 2 6 Isabella Pali-Schoell maternity leave maternity leave maternity leave Eva Untersmayr-E. 2 Sum 2 8 14

3. Teaching SS* WS* total W+S oral Exams Erika Jensen-Jarolim 6.85 5.00 11.85 2 Enikö Kállay 1.90 8.91 10.81 Isabella Pali-Schoell maternity leave maternity leave maternity leave maternity leave Eva Untersmayr-E. 3.16 6.21 9.37 1 Beatrix Pfanzagl 6.43 3.27 9.70 Sum 18.34 23.39 41.73 3

4 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 13

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

1.1.1 Publications a) Peer-reviewed original articles

Nr. Article IF Class pro-rat IF 1. Roth-Walter F, Moskovskich A, Gomez-Casado C, Diaz- 3.534 TOP 3.534 Perales A, Oida K, Singer J, Kinaciyan T, Fuchs HC, Jensen-Jarolim E. Immune suppressive effect of cinnamaldehyde due to inhibition of proliferation and induction of apoptosis in immune cells: implications in cancer. PLoS ONE 9(10): e108402. doi:10.1371/journal.pone.0108402, October 1 2. Manzano-Szalai K, Thell K, Willensdorfer A, Weghofer M, 1.636 Std. 1.636 Pfanzagl B, Singer J, Ritter M, Stremnitzer C, Flaschberger I, Michaelis U, Jensen-Jarolim E. Adeno- associated virus-like particles as new carriers for B-cell vaccines: testing immunogenicity and safety in BALB/c mice. Viral Immunol. 2014 Nov; 27(9):438-448. doi: 10.1089/vim.2014.0059. Epub, Sep 23 3. Roth-Walter F, Pacios LF, Gomez-Casado C, Hofstetter G, 3.534 TOP 3.534 Roth GA, Singer J, Diaz-Perales A, Jensen-Jarolim E. The major cow milk allergen Bos d 5 manipulates T-helper cells depending on its load with siderophore-bound iron. PLoS One. 2014; 9(8): e104803. doi:10.1371/journal.pone.0104803, Published online, Aug12 4. Marzban G, Kinaciyan T, Maghuly F, Brunner R, Gruber C, 1.000 Std. 0.200 Hahn R, Jensen-Jarolim E, Laimer M. Impact of sulfur and vitamin C on the allergenicity of Mal d 2 from apple (Malus domestica). J Agric Food Chem. 2014 Jul 30;62(30):7622- 30. doi: 10.1021/jf5020878. Epub 2014 Jul 16. 5. Meshcheryakova A, Tamandl D, Bajna E, Stift J, 3.534 TOP 0.707 Mittlboeck M, Svoboda M, Heiden D, Stremitzer S, Jensen-Jarolim E, Grünberger T, Bergmann M, Mechtcheriakova D. B cells and ectopic follicular structures: novel players in anti-tumor programming with prognostic power for patients with metastatic colorectal cancer. PLoS One. 9(6): e99008. doi: 10.1371/journal.pone.0099008. eCollection Jun 6 6. Roth-Walter F, Gomez-Casado C, Pacios LF, Mothes- 4.600 TOP 4.600 Luksch N, Roth GA, Singer J, Diaz-Perales A, Jensen- Jarolim E. Bet v 1 from birch pollen is a lipocalin-like protein acting as allergen only when devoid of iron by promoting Th2 lymphocytes. J Biol Chem. Jun 20; 289(25):17416-21. doi: 10.1074/jbc.M114.567875. Epub May 5. 7. Singer J, Fazekas J, Wang W, Weichselbaumer M, Matz 6.107 TOP 6.107 M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, Willmann M, Stockner T, Spillner E, Kunert R, Jensen-Jarolim E. Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. Mol Cancer Ther. Jul; 13(7):1777-1790. 14

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

doi: 10.1158/1535-7163.MCT-13-0288. Epub, Apr 22 8. Stremnitzer C, Manzano-Szalai K, Starkl P, Willensdorfer 5.995 TOP 5.995 A, Schrom S, Singer J, Reichart U, Akira S, Jensen- Jarolim E. Epicutaneously applied Der p 2 induces a strong TH 2-biased antibody response in C57BL/6 mice, independent of functional TLR4. Allergy. Jun; 69(6):741- 751. doi: 10.1111/all.12399. Epub, Apr 16 9. Oida K, Matsuda A, Jung K, Xia Y, Jang H, Amagai Y, Ahn 5.078 TOP 1.016 G, Nishikawa S, Ishizaka S, Jensen-Jarolim E, Matsuda H, Tanaka A. Nuclear factor-ĸB plays a critical role in both intrinsic and acquired resistance against endocrine therapy in human breast cancer cells. Sci Rep. 4:4057. doi: 10.1038/srep04057. Feb 17 10. Mirkina I, Hadzijusufovic E, Krepler C, Mikula M, 3.534 TOP 0.707 Mechtcheriakova D, Strommer S, Stella A, Jensen- Jarolim E, Höller C, Wacheck V, Pehamberger H, Valent P. Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co- expressing ErbB4, EPO-R and NGF-R. PLoS One. 9(1):e84417. doi: 10.1371/journal.pone.0084417. eCollection, Jan 29 11. Jordakieva G, Wallmann J, Schmutz R, Lemell P, 3.534 TOP 3.534 Wegmann M, Nittke T, Mittlböck M, Fehrenbach H, Godnic-Cvar J, Zieglmayer R, Jensen-Jarolim E. Peripheral erythrocytes decrease upon specific respiratory challenge with grass pollen allergen in sensitized mice and in human subjects. PLoS One. 9(1):e86701. doi: 10.1371/journal.pone.0086701. eCollection, Jan 22 12. Fürst E, Foster HR, Ward JP, Corrigan CJ, Cousins DJ, 5.993 TOP 5.993 Woszczek G. Sphingosine-1 phosphate induces pro- remodelling response in airway smooth muscle cells. Allergy 2014, Nov; 69(11): 1531-9 13. Hummel D, Aggarwal A, Borka K, Bajna E, Kállay E, 4.049 Std. 4.049 Horvath HC. The vitamin D system is deregulated in pancreatic diseases. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt B:402-9. 14. Fetahu IS, Höbaus J, Aggarwal A, Hummel DM, 5.007 TOP 5.007 Tennakoon S, Mesteri I, Baumgartner-Parzer S, Kállay E. Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. Int J Cancer. 2014 Nov 1;135(9):2014-23. 15. Fetahu IS, Hummel DM, Manhardt T, Aggarwal A, 4.049 Std. 4.049 Baumgartner-Parzer S, Kállay E. Regulation of the calcium-sensing receptor expression by 1,25- dihydroxyvitamin D3, interleukin-6, and tumor necrosis factor alpha in colon cancer cells. J Steroid Biochem Mol Biol. 2014 Oct;144PA:228-231. 16. Hummel DM, Fetahu IS, Gröschel C, Manhardt T, Kállay 4.049 Std. 4.049 E. Role of proinflammatory cytokines on expression of vitamin D metabolism and target genes in colon cancer 15

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

cells. J Steroid Biochem Mol Biol. 2014 Oct;144PA:91-95. sum 65.233 53.103

b) Invited Articles & Reviews with IF

Nr. Article IF Class pro-rata IF

sum

c) Invited Articles & Reviews without IF: n = 1

1. Singer, J, Jensen-Jarolim E. IgE-based Immunotherapy of Cancer -A Comparative Oncology Approach. J Carcinog Mutagen 5(3):1000176. May 31

2. Jensen-Jarolim, E. Happy 25th birthday, Bet v 1!, Invited Editorial, World Allergy Organ J, 2014 (Editorial), World Allergy Organ J. 7(1):14. doi: 10.1186/1939-4551- 7-14. eCollection Jun 3, 2014

3. Fetahu, IS, Höbaus J, Kállay E. Vitamin D and the epigenome. Front Physiol. 2014 Apr 29;5:164. eCollection 2014. Review (Will have an estimated IF over 3 in 2015).

d) Book contributions: n =5

Erika Jensen-Jarolim 1. Jensen-Jarolim E, Definition of Comparative Medicine: History and New Identity, pages 1-18, Editor: Jensen-Jarolim E, Comparative Medicine - Anatomy and Physiology, Springer, ISBN: 978-3-7091-1558-9 (Print) 978-3-7091-1559-6 (Online) 2. Zeugswetter FK, Jensen-Jarolim E4, Body Messaging: The Endocrine Systems, pages: 119-138, Editor: Jensen-Jarolim E, Comparative Medicine - Anatomy and Physiology, Springer, ISBN: 978-3-7091-1558-9 (Print) 978-3-7091-1559-6 (Online) 3. Jensen-Jarolim E, Schöpper H, Grabner S, Volume and Clearance: Kidneys and Excretory Systems, pages 161-178, Editor: Jensen-Jarolim E, Comparative Medicine - Anatomy and Physiolog, Springer, ISBN: 978-3-7091-1558-9 (Print) 978-3-7091-1559- 6 (Online) 4. Roth-Walter F, Riemer AB, Jensen-Jarolim E, Common Concepts of Immune Defense: Innate Immunity, the oldest type of defense, pages: 220-242, Editor: Jensen-Jarolim E, Comparative Medicine - Anatomy and Physiology, Springer, ISBN: 978-3-7091-1558-9 (Print) 978-3-7091-1559-6 5. Roth-Walter F, Jensen-Jarolim E, Stockinger H, Common Concepts of Immune Defense: Principles and Comparative Aspects of adaptive immunity, pages: 243-266, Jensen-Jarolim E, Comparative Medicine - Anatomy and Physiology, Springer, ISBN: 978-3-7091-1558-9 (Print) 978-3-7091-1559-6 (Online)

Performance Report 2014 – Division 1 Comparative Immunology and Oncology e) Abstracts, printed in periodicals: n = 0

f) Abstracts, in congress proceedings or abstract books: n = 51

1. Roth-Walter, F, Gomez-Casado C, Pacios LF, Mothes –Luksch N, Roth GA, Singer J, Gotovina J, Diaz-Perales A , Jensen-Jarolim E. The major birch pollen allergen Bet v 1 is a lipocalin-like protein, whose function depends on iron. World Allergy Organization (WAO) International Scientific Conference (WISC) 2014, and the XLI Congress of the Brazilian Association of Allergy and Immunology (ASBAI), Rio de Janeiro, Brazil, December 6-9, 2014

2. Oida, K, Einhorn L, Vrtala S, Resch Y, Panakova L, Roth-Walter F, Fazekas J, Matsuda H, Tanaka A, Jensen-Jarolim. House dust mites are an important source of enzymes that disrupt epithelial integrity. Conference for BioSignal and Medicine, Shizuoka, Japan, November 22-23, 2014

3. Aggarwal, A, Tennakoon S, Wohlgenannt M, Boudot C, Mentaverri R, Baumgartner- Parzer S, Kállay E. The Calcium-Sensing Receptor: a Tumor Suppressor in the Colon. Austrian Society for Bone and Mineral Research Annual Meeting, Vienna, Austria, November 14-15, 2014

4. Gröschel, C, Aggarwal A, Tennakoon S, Höbaus J, Wohlgenannt M, Teresa Manhardt T, Marian B, Kállay E. 1,25-dihydroxyvitamin D3 modulates the wnt-pathway in colorectal adenoma cells: Herbsttagung Austrian Society for Bone and Mineral Research Annual Meeting, Vienna, Austria, November 14-15, 2014

5. Tennakoon, S, Karpat I, Aggarwal A, Hegedus L, Kallay E. Calcium Sensing Receptor Signalling in Colon Cancer Cells. Austrian Society for Bone and Mineral Research Annual Meeting. Vienna, Austria, November 14-15, 2014

6. Oida, K, Einhorn L, Vrtala S, Resch Y, Panakova L, Roth-Walter F, Fazekas J, Matsuda H, Tanaka A, Jensen-Jarolim E. House dust mite extract is a robust source of enzymes that impair epithelial barrier function. Annual meeting of the Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI); Salzburg, Austria; November 6- 8, 2014

7. Müller, HA, Pacios LF, Gomez-Casado C, Hostetter G, Roth GA, Singer J, Diaz- Perales A, Jensen-Jarolim E, Roth-Walter F. The major cow milk allergen, Bos d 5, is able to bind siderophore bound iron and influences T-helper cells according to its binding state. Annual meeting of the Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI); Salzburg, Austria; November 6-8, 2014

8. Diesner, SC, Schultz C, Ackaert C, Ostingh GJ, Ondracek A, Stremnitzer C, Heiden D, Singer J, Roth-Walter F, Fazekas J, Eiwegger T, Szepfalusi Zs, Jensen-Jarolim E, Stutz EH, Duschl A, Untersmayr E. Nitrated Beta-Lactoglobulin Enhances The Anaphylactic Response in a Murine Food Allergy Model. Annual meeting of the Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI); Salzburg, Austria; November 6-8, 2014

9. Fazekas, J, Singer J, Wang W, Weichselbaumer M, Mader A, Matz M, Steinfellner W, Sobanov Y, Mechtcheriakova D, Willmann M, Spillner E, Kunert R, Jensen-Jarolim E. Can225IgG, a new canine anti-EGFR antibody. Annual meeting of the Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI); Salzburg, Austria; November 6- 8, 2014

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

10. Diesner, SC, Schultz C, Wang X, Beitl K, Roth-Walter F, Heiden D, Ondracek A, Singer J, Fazekas J, Stremnitzer C, Eiwegger T, Szepfalusi ZS, Pali-Schöll I, Jensen-Jarolim E, Gabor F, Untersmayr E. Neuraminidase-coated, allergen-loaded microparticles are a safe and efficient novel food allergy treatment option. Annual meeting of the Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI); Salzburg, Austria; November 6-8, 2014

11. Platzer, B, Elpek KG, Cremasco V, Baker K, Schultz C, Dehlink E, Blumberg R, Turley SJ, Fiebier E. Dendritic cells use IgE-mediated antigen cross-presentation to generate cytotoxic T cells in response to low dose soluble antigen. Annual meeting of the Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI); Salzburg, Austria; November 6-8, 2014

12. Einhorn, L, Fazekas J, Muhr M, Schoos A, Panakova L, Manzano-Szalai K, Oida K, Singer J, Jensen-Jarolim E. Expression of recombinant canine, feline and equine FcepsilonRI-alpha chains for improved IgE profiling in these species. Annual meeting of the Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI); Salzburg, Austria; November 6-8, 2014

13. Einhorn, L, Muhr M, Schoos A, Panakova L, Manzano-Szalai K, Singer J, Fazekas J, Jensen-Jarolim E. Expression and characterization of recombinant veterinary patient- specific FcεRIα as diagnostic tool for allergic diseases. 27th Annual Congress of the European Society and College of Veterinary Dermatology (ESVD-ECVD); Salzburg, Austria; October 11-13, 2014

14. Singer, J, Fazekas J, Wang W, Weichselbaumer M, Matz M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, Stockner T, Spillner E, Kunert R, Willmann M, Thalhammer J, Jensen-Jarolim E. IgE-based Immunotherapy of Cancer – A Comparative Oncology Approach. 9th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine, Athens, Greece, October 9 –11, 2014

15. Fazekas, J, Singer J, Wang W, Wichselbaumer M, Matz M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, Willmann M, Stockner T, Spillner E, Kunert R, Jensen-Jarolim E. Can225IgG, a monoclonal antibody targeting EGFR for veterinary oncology. 9th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine, Athens, Greece, October 9 –11, 2014

16. Einhorn, L, Fazekas J, Muhr M, Schoos A, Panakova L, Manzano-Szalai K, Oida K, Singer J, Jensen-Jarolim E. Recombinant fcepsilonri-alpha as diagnostic tool for evaluating allergic sensitization in dogs, cats and horses. 5th Retreat Center for Pathophysiology, Infectiology and Immunology, Bernhard Gottlieb University Clinic of Dentistry September 16, 2014, Vienna Competence Center, September 17th, 2014

17. Roth-Walter, F, Pacios LF, Gomez-Casado C, Hofstetter G, Roth GA, Singer J, Diaz- Perales A, Jensen-Jarolim E. The Ability of The Major Cow Milk Allergen, Bos d 5, To Manipulate T-helper Cells Depends On Its Load With Siderophore-bound Iron. 5th Retreat Center for Pathophysiology, Infectiology and Immunology, Bernhard Gottlieb University Clinic of Dentistry September 16, 2014, Vienna Competence Center, September 17th, 2014

18. Roth-Walter, F, Gomez-Casado C, Pacios LF, Mothes –Luksch N, Gotovina J, Hofstetter G, Roth GA, Singer J, Diaz-Perales A, Jensen-Jarolim E. Bet v 1, a lipocalin- like allergen, manipulates T-helper cells depending on its load with siderophore-bound iron. Bernhard Gottlieb University Clinic of Dentistry September 16, 2014, Vienna Competence Center, September 17th, 2014 18

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

19. Fazekas, J, Willmann M, Weichselbaumer M, Singer J, Pagitz M, Starkl P, Knittelfelder R, Thell K, Willensdorfer A, Thalhammer JG, Jensen-Jarolim E. A phase I/II xenogeneic CEA vaccination study in canine mammary carcinoma patients. Bernhard Gottlieb University Clinic of Dentistry September 16, 2014, Vienna Competence Center, September 17th, 2014

20. Diesner, SC, Schultz C, Ackaert C, Ostingh GJ, Ondracek A, Stremnitzer C, Heiden D, Singer J, Roth-Walter F, Fazekas J, Eiwegger T, Szepfalusi Zs, Jensen-Jarolim E, Stutz EH, Duschl A, Untersmayr E. The Influence of Food Protein Nitration on the Anaphylactic Response in a Murine Food Allergy Model. Bernhard Gottlieb University Clinic of Dentistry September 16, 2014, Vienna Competence Center, September 17th, 2014

21. Roth-Walter, F, Pacios LF, Gomez-Casado C, Hofstetter G, Roth GA, Singer J, Diaz- Perales A, Jensen-Jarolim E. Bos d 5, the major cow milk allergen, manipulates T- helper cells depending on its load with siderophore-bound iron. Österreichische Gesellschaft für Molekulare Biowissenschaften und Biotechnologie (OEGMBT) 2014 Vienna, Austria, 6th ÖGMBT Annual Meeting "Life Sciences meet Entrepreneurship", 15-18 September 2014

22. Aggarwal, A, Tennakoon S, Wohlgenannt M, Boudot C, Mentaverri R, Baumgartner- Parzer S, Kállay E. The Calcium Sensing Receptor is a tumor suppressor in the colon regulating proliferation, differentiation, and epithelial to mesenchymal transition. 13th International Meeting of the European Calcium Society, Aix-en Provence, France, September 13-17, 2014

23. Hegedüs, L, Garay T, Molnar E, Varga K, Grusch M, Kallay E, Hegedus B, Enyedi A. The role of the plasma membrane Ca2+ pump PMCA4b in Ca2+ homeostasis and migration of BRAF mutant melanoma cells. Book of Abstracts p. 55. 13th International Meeting of the European Calcium Society, Aix-en Provence, France, September 13-17, 2014

24. Tennakoon, S, Karpat I, Aggarwal A, Hegedus L, Kallay E. Calcium Sensing Receptor Signalling in Colon Cancer Cells. 13th International Meeting of the European Calcium Society, Aix-en Provence, France, September 13-17, 2014

25. Roth-Walter, F, Gomez-Casado C,.Pacios L F, Mothes –Luksch N, Roth GA, Singer J, Diaz-Perales A, Jensen-Jarolim E. Bet v 1, a lipocalin-like allergen, whose function depends on iron. Collegium Internationale Allergologicum, Petersburg, Germany, Sept 12-18, 2014

26. Stremnitzer ,C, Szalai-Manzano K, Mildner M, Tschachler E, Pieper M, König P, Mothes-Luksch N, Pacios L, Roth-Walter F, Jensen-Jarolim E. House dust mite allergens manipulate barrier integrity and immune balance. Collegium Internationale Allergologicum, Petersburg, Germany, Sept 12-18, 2014

27. Jirak, P, Gerger D, Glenk LM, Jensen-Jarolim E, Wegner C, Stöllberger C. Interest in animal-assisted therapy in patients with implanted cardiac electronic devices. Animals and Humans together: Integration in Society. International Society for Anthrozoology (ISAZ) 2014, Vienna, Austria, July 19- 22

28. Glenk, LM, Belik C, Marashi V, Palme R, Jensen-Jarolim E. Personality Ratings and Cortisol Responses in Experimenters of (Laboratory) Animal Studies – Planning of a pilot study. Animals and Humans together: Integration in Society. International Society for Anthrozoology (ISAZ 2014), Vienna, Austria, July 19- 22,

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

29. Liebhart, D, Paudel S, Wernsdorf P, Käser T, Meitz S, Hess C, Saalmüller A, Jensen- Jarolim E, Hess M. Failure of 5-fluorouracil and cyclosporin to induce depletion of a particular population of leucocytes determined by flow cytometry and quantitative imaging analyses. XIII Avian Immunology Research Group Conference, Guelph, Ontario, Canada, July 16-19, 2014

30. Tennakoon, S, Aggarwal A, Hegedus L, Wohlgenannt M, Kallay E. Calcium sensing receptor mediated downstream signalling in colonocytes. 23rd European Association for Cancer Research (EACR) Congress 2014, Munich, Germany, July 8, 2014

31. Gröschel, C, Aggarwal A, Wohlgenannt M, Manhardt T, Marian B, Kallay E. Modulating the wnt-pathway in colorectal adenoma cells by 1,25-dihydroxyvitamin D3. 23rd European Association for Cancer Research (EACR) Congress 2014, Munich, Germany, July 8, 2014

32. Brom, C, Buchtová M, Šisler V, Děchtěrenko F, Palme R, Glenk LM. Cortisol levels and experiencing of flow: are they related? A study with seven different interventions. 9th FENS Forum of Neuroscience, Milan, Italy, July 5-9, 2014

33. Aggarwal, A, Hoebaus J, Tennakoon S, Kállay E. The role of the calcium sensing receptor in the anti-neoplastic effects of active vitamin D in the colon. 17th Vitamin D Workshop, Chicago, June 17– 20, 2014

34. Gröschel, C, Aggarwal A, Wohlgenannt M, Manhardt T, Marian B, Kallay E. 1,25- dihydroxyvitamin D3 modulates the wnt-pathway in colorectal adenoma cells. 17th Vitamin D Workshop, Chicago, June 17 – 20, 2014

35. Singer, J, Szalai K, Thell K, Lukschal A, Fazekas J, Stremnitzer C, Roth-Walter F, Weghofer M, Ritter M, Michaelis U, Jensen-Jarolim E. HER-2 mimotope fusion proteins with AAV surface antigen VP3 prevent BT474 tumor growth in a xenograft mouse model. 10th Young Scientist Association (YSA) Symposium 2014, Vienna, Austria, June 11-12, 2014

36. Hegedüs, L, Garay T, Molnar E, Varga K, Grusch M, Kallay E, Enyedi A. The role of the plasma membrane Ca2+ pump PMCA4b in Ca2+ homeostasis and migration of BRAF mutant melanoma cells 10th Young Scientist Association (YSA) Symposium 2014, Vienna, Austria, June 11-12, 2014

37. Gröschel, C, Aggarwal A, Wohlgenannt M, Manhardt T, Marian B, Kállay E. 1,25- dihydroxyvitamin D3 modulates the wnt-pathway in colorectal adenoma cells. 10th Young Scientist Association (YSA) Symposium 2014, Vienna, Austria, June 11-12, 2014

38. Fazekas, J, Singer J, Wang W, Weichselbaumer M, Matz M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, Willmann M, Stockner T, Spillner E, Kunert R, Jensen-Jarolim E. Generation of the first caninized immunotherapeutic antibody for the treatment of EGFR-positive canine cancer. 10th Young Scientist Association (YSA) Symposium 2014, Vienna, Austria, June 11-12, 2014

39. Einhorn, L, Muhr M, Schoos A, Panakova L,Kumiko O, Manzano-Szalai K, Singer J, Fazekas J, Jensen-Jarolim E Einhorn, L, Muhr M, Schoos A, Panakova L, Kumiko O, Manzano-Szalai K, Singer J, Fazekas J, Jensen-Jarolim E. Establishment of recombinant species-specific FcεRIα as diagnostic tool for IgE-mediated diseases in dogs, cats and horses. 10th Young Scientist Association (YSA) Symposium 2014, Vienna, Austria, June 11-12, 2014

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

40. Roth-Walter, F, Moskovskich A, Willensdorfer A, Gomez-Casado C, Glenk LM, Pollak- Monje Quiroga D, Jensen-Jarolim E. Site-specific protection against cinnamaldehyde depends on its haptenous state in a mouse model of fragence allergy. European Academy of Allergy and Clinical Immunology (EEACI) Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

41. Singer, J, Szalai K, Thell K, Lukschal A, Fazekas J, Stremnitzer C, Roth-Walter F, Weghofer M, Ritter M, Michaelis U, Jensen-Jarolim E. Adeno-associated viruses (AAV) coupled with HER-2 mimotopes are safe and effective anti-tumor vaccines in a xenograft mouse model. European Academy of Allergy and Clinical Immunology (EEACI) Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

42. Stremnitzer C, Szalai K, Willensdorfer A, Starkl P, Pieper M, König P, Mildner M, Tschachler E, Reichart U, Jensen-Jarolim E. Papain impairs the epidermal barrier and – independent of its enzymatic activity – exhibits strong allergenic potential via the skin. European Academy of Allergy and Clinical Immunology (EEACI) Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

43. Stremnitzer, C, Szalai K, Starkl P, Willensdorfer A, Schrom S, Singer J, Reichart U, Akira S, Jensen-Jarolim E. Der p 2 is a strong epicutaneous allergen even in the absence of TLR4. European Academy of Allergy and Clinical Immunology (EEACI) Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

44. Diesner, SC, Schultz C, Wang XY, Beitl K, Roth-Walter F, Heiden D, Ondracek A, Singer J, Fasekas J, Stremnitzer C, Fürst E, Eiwegger T, Szépfalusi Zs, Pali-Schöll I, Jensen-Jarolim E, Gabor F, Untersmayr E. Oral immunotherapy with allergen-loaded neuraminidase-coated microparticles protects mice from food-induced anaphylaxis. European Academy of Allergy and Clinical Immunology (EEACI) Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

45. Fazekas, J Singer J, Wang W, Weichselbaumer M, Matz M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, Willmann M, Stockner T, Spillner E, Kunert R, Jensen-Jarolim E. Can225IgG, the first “caninized“ antibody against EGFR is highly effective in mediating tumor cell growth inhibition and phagocytosis in vitro. European Academy of Allergy and Clinical Immunology (EEACI) Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

46. Einhorn, L, Muhr M, Schoos A, Singer J, Panakova L, Willensdorfer A, Manzano-Szalai K, Fazekas J, Jensen-Jarolim E. Generation and characterization of recombinant species-specific FcεRIα for diagnosis of allergic diseases in veterinary patients. European Academy of Allergy and Clinical Immunology (EEACI) Congress 2014, Copenhagen, Denmark, 7-11 June, 2014.

47. Hegedűs, L, Pászty K, Varga K, Enyedi Á. A PMCA fehérjék szerepe az NFAT és c-fos Ca2+ függő transzkripciós faktorok szabályozásában. 44. Membran-Transport Conference, Sümeg, Ungarn. Mai 20-23, 2014

48. Fetahu, I, Höbaus J, Aggarwal A, Hummel DM, Tennakoon S, Mesteri I, Baumgartner- Parzer S, Kallay E: Epigenetic regulation of the calcium-sensing receptor expression in colorectal cancer. Keystone symposium, Santa Fe, USA, April 15, 2014

49. Aggarwal, A, Tennakoon S, Wohlgenannt M, Boudot C, Mentaverri R, Baumgartner- Parzer S, Kállay E. The Tumor Suppressor Calcium Sensing Receptor Regulates Proliferation and Promotes Differentiation in Colon Cancer. American Association for Cancer Research Annual Meeting, San Diego, USA, April 5-9, 2014

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

50. Aggarwal, A, Tennakoon S, Wohlgenannt M, Boudot C, Mentaverri R, Baumgartner- Parzer S, Kállay E. Loss of the Calcium Sensing Receptor provides a growth advantage to colon cancer cells. 19th Annual Meeting of the Austrian Society for Endocrinology and Metabolism, Austria, April 4, 2014

51. Gröschel, C, Aggarwal A, Wohlgenannt M, Manhardt T, Marian B, Kállay E. The impact of 1,25-dihydroxyvitamin D3 on the wnt-pathway in colorectal adenoma cells. 19th Annual Meeting of the Austrian Society for Endocrinology and Metabolism, Austria, April 4, 2014

g) Teaching Scripts and Books: n = 1,

1. Comparative Medicine: Anatomy and Physiology (Ed. Erika Jensen-Jarolim, Springer publisher), ISBN: 978-3-7091-1558-9, (see 2.1.1.d)

h) Articles in Medical Journals: n = 0

i) Public activity:

Erika Jensen-Jarolim Title of publication Impact in media (active) (all retrospective estimatiosn of media response) Press Release: Grundlage der allergischen Reaktion auf 18 (1 print) in German Kuhmilch-Allergen erforscht

Press Release: Weltweit erste Krebsimmuntherapie für 17 (4 print) in German den Hund entwickelt

Press Release: Grundlage der allergischen Reaktion auf 10 (3 print) Birkenpollen identifiziert

Press Release: OTS0254. ÖKV verleiht in Kooperation mit RotePfote Förderpreis zum Thema 2 (14 online in German) Krebsbekämpfung

Press Release: OTS0192. Prävention kann Leben retten 2 (8 online in German)

Press Release: OTS0108. Hochkarätiger Wechsel an 6 online in German der Spitze der interdisziplinären Krebsforschung

General Media Coverage

1. "Vom Nutzen des Unnützlichen", Barbara Stöckl, ORFIII, Podiums discussion, October 16, 2014

2. Eisenmangel macht aus Kuhmilchprotein ein Allergen, Science.apa.at, August 22

3. Erste Krebstherapie für Hunde entwickelt, Wien Heute, Juli 9, p 12

4. Scientists develop the first cancer immunotherapy for dogs, Medical News Today online, July 8, http://www.medicalnewstoday.com/releases/279270.php

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

5. Krebsimmuntherapie für Hunde speziell entwickelt, Vorarlberger Tageszeitung, Juli 6, p 68

6. Krebsimmuntherapie für Hunde entwickelt, Kronen Zeitung, Juli 6, p 14

7. Cancer Immunotherapy For Dogs Developed, Science 2.0, July 4, United States, http://www.science20.com/news_articles/cancer_immunotherapy_for_dogs_developed- 139960

8. Wiener Forscher entwickelten erste Krebsimmuntherapie für Hunde, DerStandard.at, July 4, http://derstandard.at/2000002694678/Wiener-Forscher-entwickelten-erste- Krebsimmuntherapie-fuer-Hunde

9. Erste Krebsimmuntherapie für Hunde entwickelt, Science.apa.at, July 4

10. Froh mit Hund und Co. Warum uns Tiere gut tun, Weekend Magazin, Nr. 18.

11. Junge Krebsforscherin ausgezeichnet, Vetmedmagazin, Nr 2/20

12. Pollen, Milben, Katzen: Allergien im Anflug-Forschen und Entdecken, 1/2014,

13. Paartherapie-Profil, p 42-43, June 18, 2014,

14. AllergoOnkologie - was ist das?-HundeWelt, 3/2014, p 14-20

15. Warum Birkenpollen Allergien auslösen, Wiener Zeitung, June 6, Nr. 110, p 29

16. Warum Birken wirken, Ärzte Magazin, 14/2014, p 8

17. Birkenpollen-Allergie: Eisen beschwichtigt Allergen, Medizin.at, June 6

18. Pollen ohne Eisen können zu Allergieauslösern werden, Salzburger Nachrichten, Nr. 130, p 22

19. Grundlage der allergischen Reaktion auf Birkenpollen identifiziert, Medical University Vienna, June 5, http://www.meduniwien.ac.at/homepage/news-und- topstories/?tx_ttnews%5Btt_news%5D=4828&cHash=b5fc8a484a4e7bf1e6c4c8588e0f d75f

20. Grundlage der allergischen Reaktion auf Birkenpollen identifiziert, DerStandard.at, June 5, http://derstandard.at/2000001820063/Grundlage-der-allergischen-Reaktion- auf-Birkenpollen-identifiziert

21. "Eisenmangel" macht Proteine allergen, Wiener Zeitung, June 5, http://www.wienerzeitung.at/themen_channel/wissen/mensch/635539_Eisenmangel- macht-Proteine-allergen.html

22. "Eisenmangel" macht Proteine allergen, Science.apa.at, June 5

23. Mensch und Tier: alle allergisch?, Tag der offenen Türe VetMed., May 24, 2014

24. Zukunft für Allergiker.Interview with Gabriela Euler-Rolle-Ö3, April 6, 2014

25. Science Talk with Barbara Stöckl, ORFIII, April 23, 21:45

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

Eva Untersmayr-Elsenhuber

1. Allergieprävention in Schwangerschaft, Stillzeit und Kelinkindalter. Science VHS Vienna lecture series. November 10, 2014

2. Nahrungsmittelallergie – eine harte Nuss zu knacken. Science VHS Vienna lecture series. October 24, 2014

3. Lay Information: Workshop: Lange Nacht der Forschung: Nahrungsmittelallergie – eine harte Nuss zu knacken

4. Television Interview: ORF 2, Wien heute: Nahrungsmittelunverträglichkeiten

1.1.2. Research Awards: n = 15

1. Franziska Roth-Walter: WISC Abstract Award, Rio, 6-9 December 2014 2. Josef Singer: Stefan Wagner Dissertationspreis of the Austrian Sc. of Allergology and Immunology 3. Judit Fazekas: EAACI Congress Scholarship for the European Academy of Allergy and Clinical Immunology Congress 2014, Copenhagen, from 7-11 June 2014 4. Eva Untersmayr-Elsenhuber: Viennese Economic Chambers Award 2014 5. Eva Untersmayr-Elsenhuber: Abstract Award at the European Academy of Allergy and Clinical Immunology Congress 2014, Copenhagen, from 7-11 June 2014 6. Elisabeth Fürst: FFG/BMVIT Career Grant: Relocation Grant 01/2014 7. Cornelia Schultz: Exzellenz-scholarship of the Federation of Austrian Industries Carinthia 8. Cornelia Schultz: Scholarship of the Marshall Plan Foundation 9. Abhishek Aggarwal: Drabikowski Award for his presentation at the 13th International Meeting of the European Calcium Society, at Aix-en-Provence, in September 2014. 10. Abhishek Aggarwal: Young Investigator Award by the Austrian Society for Endocrinology and Metabolism, Vienna, April 2014. 11. Abhishek Aggarwal: EACR Fellowship by European Association for Cancer Research for an Academic Exchange with Cardiff University, UK, 2014. 12. Abhishek Aggerwal: 3 Platz: Young Scientist Awards 2014 des Vereins RotePfote. 13. Irfete Fetahu: EACR Fellowship by European Association for Cancer Research for an Academic Exchange with Oxford University, UK, 2014. 14. Samawanscha Tennakoon: EACR Fellowship by European Association for Cancer Research for an Academic Exchange with Cardiff University, UK, 2014. 15. Charlotte Gröschel: Travel Grant from the Comprehensive Cancer Center to attend the 17th Workshop on Vitamin D in Chicago, IL, USA, June 17-20, 2014.

1.1.3. Invited lectures: n = 27

Erika Jensen-Jarolim

1. IgG and IgE anti-Cancer antibodies, CCC Tumor Immunology Workshop, Medical University Vienna, national, April 20, 2014 24

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

2. Exkursion ins Reich der allergenen Pflanzen und Moleküle, Allergy Seminar for Physicians, Tulln, national, April 24, 2014

3. Mensch und Tier, alle allergisch?, Tag der offenen Türe, Vetmeduni Vienna, national, May 24, 2014

4. Allergy by Humans to Animals and vice versae? Comparative Aspekts of Allergology, Wörtherseesymposium, Velden, national, June 20, 2014

5. Der p 2 is a strong epicutaneous allergen even in the absence of TLR4, Symposium: Atopic dermatitis and other skin conditions: mechanisms, EAACI Copenhagen, Denmark, international, June 10, 2014

6. Welche Gefahr liegt in der Reduzierung von Wissen auf das Nützliche und Verwertbare? Science Gala of Lower, Podium discussion, Moderator Barbara Stöckl. Austria Schloss Grafenegg, national, October 16, 2014

7. Allergies and Aluminium, what is it all about? Allergy Symposium Vienna, international, October 18, 2014

8. Daily Allergy Diagnosis with the ISAC ImmunoCAP Microchip, Allergy Seminar, national, October 19, 2014

9. Practical Aspects of ImmunoCAP ISAC in the clinic, The Northern Molecular Workshop, Birmingham, UK, international, October 22, 2014

10. From Man, Mice and Dogs: The Impact of comparative medicine in tumor research, University Vienna. Opening Event of Imaging Facility, national, November 5, 2014

11. Skin Barrier Function and the Environment. Title: Environmental Allergens that Manipulate Barrier and Immune Function, World Immune Scientific Conference (WISC), Rio de Janeiro, international, December 6, 2014

Eva Untersmayr-Elsenhuber

1. Ich habe eine Unverträglichkeit gegen Nahrungsmittel: Was kann ich tun? 13th Viennese Osteoporosis Day, October 30, 2014

2. Neue Therapiestrategien bei Nahrungsmittelallergien. Drug targeting lecture series, University Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, Vienna, Austria, December 10, 2014

3. Novel treatment strategy for type I food allergy using allergen-loaded microparticles. ISPTM seminar, Vienna, Austria, June 4, 2014

4. Update on food allergy: From allergen structure to novel mechanisms. IPA Impulse seminar, Vienna, Austria, May 9, 2014

5. Gender Aspects of Allergies. Vienna Medical Association, Vienna, Austria, January 11 and February 22, 2014

6. Food allergies: from allergen to intestinal inflammation. 12th EAACI Immunology Winter School, Brasov, Rumania, January 30, 2014

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

Enikö Kallay

1. Calcium acts as a first messenger and suppresses colon cancer development by binding to the calcium sensing receptor (a G protein-coupled receptor). Annual Meeting of the Hungarian Biochemical Society, 24-27. August. 2014. Debrecen.

2. Kallay E. Epigenetic Regulations and the Vitamin D system. 9th International Conference of Anticancer Research, Sithonia, Greece, October 6-10, 2014

3. Der CaSR, ein Molekül mit vielen Facetten. Die Rolle des kalziumsensitiven Rezeptors in der Gesundheit und in Krankheit. Linz. 3.11.2014.

4. The Yin-Yang Role of the Calcium Sensing Receptor in Tumourigenesis. An Interplay between the CaSR and Vitamin D to Prevent Colorectal Cancer. INSERM, Paris, 2.12.2014.

Members of Division 1:

1. House dust mites are an important source of enzymes that disrupt epithelial integrity. Oida, K, Einhorn L, Vrtala S, Resch Y, Panakova L, Roth-Walter F, Fazekas J, Matsuda H, Tanaka A, Jensen-Jarolim. Conference for BioSignal and Medicine, Shizuoka, Japan, November 22-23, 2014

2. The major cow milk allergen, Bos d 5, is able to bind siderophore bound iron and influences T-helper cells according to its binding state. Müller, HA, Pacios LF, Gomez- Casado C, Hostetter G, Roth GA, Singer J, Diaz-Perales A, Jensen-Jarolim E, Roth- Walter F. Annual ÖGAI meeting; Salzburg, Austria; November 6-8, 2014

3. Expression and characterization of recombinant veterinary . patient-specific FcεRIα as diagnostic tool for allergic diseases. Einhorn, L, Muhr M, Schoos A, Panakova L, Manzano-Szalai K, Singer J, Fazekas J, Jensen-Jarolim E. 27th annual congress of ESVD-ECVD; Salzburg, Austria; 11-13 October 2014

4. IgE-based Immunotherapy of Cancer • A Comparative Oncology Approach. Singer, J. 19th World Congress on Advances in Oncology and 17th International, Symposium on Molecular Medicine, Athens, Greece, international, October 9-11, 2014

5. Diesner, SC, Schultz C, Wang XY, Beitl K, Roth-Walter F, Heiden D, Ondracek A, Singer J, Fasekas J, Stremnitzer C, Fürst E, Eiwegger T, Szépfalusi Zs, Pali-Schöll I, Jensen-Jarolim E, Gabor F and Untersmayr E. Oral immunotherapy with allergen- loaded neuraminidase-coated microparticles protects mice from food-induced anaphylaxis. EAACI 2014 : European Academy of Allergy and Clinical Immunology Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

6. Stremnitzer, C, Szalai K, Starkl P, Willensdorfer A, Schrom S, Singer J, Reichart U, Akira S, Jensen-Jarolim E. Der p 2 is a strong epicutaneous allergen even in the absence of TLR4. EAACI 2014, European Academy of Allergy and Clinical Immunology Congress 2014, Copenhagen, Denmark, 7-11 June, 2014

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

1.1.4. Congress organization

Division member National congress Intern. congress, Name: Name, date Function Name, date Function

1.1.5. Hosting speakers

division member Speaker´s name Affiliation Date Jensen-Jarolim E Prof. Edda Fiebiger, MD Boston Childrens Hospital, 02.01.2014 Havard University Division of Medical Sciences Jensen-Jarolim E Prof. Felisbina Luisa Queiroga University of Trás-os-Montes 22.05.2014 and Alto Douro Vila Real,

Portugal Department of Veterinary Sciences Jensen-Jarolim E Dr. Wolfgang Schröder Technische Universität 09.10.2014 Hamburg-Harburg Inst. für Messtechnik Jensen-Jarolim E Dr. Lajos Balogh, DVW NRIRR, Budapest Laboratory 01.12.2014 of Applied Radioisotopes Untersmayr- Prof. Burkhard Kleuser Institute of Nutritional 12.12.2014 Elsenhuber E Science, Faculty of Mathematics and Natural Science, University Potsdam, Germany

1.1.6. Mobility

Name Program University, Time frame Division In Out Country Stefanie SFB F4606-B19 FH Technic. Wien 2014 – ongoing 1 x Wagner

Jelena CCHD, W1205- University of 2014 – ongoing 1 x Gotovina B09 Veterinary Medicine, Vienna

Lukas Einhorn MCCA, W1248- BOKU 2013 – ongoing 1 x B13

Galateja N094 Medical University 2013 – 1 x Jordakieva Vienna, Internal (ongoing) Medicine II

Lisa-Maria St. Anna Childrens´ 2013 – 1 x Glenk Hospital (ongoing)

Josef Singer FWF-P23398- Experimental 2 months (2014) 1 x B11 Nuclear Medicine, Medical University of Vienna

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

Josef Singer FWF-P23398- Division of 6 months (2014) 1 x B11 Infectious Diseases and Tropical Medicine at the Department of Medicine I

Cornelia -- Boston Children’s January 7, 1 x Schultz Hospital, United 2014- States September

Ass. Prof. Dr. EAACI JMA Vitebsk State June 23,2014 to 1 x Natalia Mentorship Medical University, July 04,2014 Aliakhnovich program Belarus

Abhishek Multifaceted Cardiff University, 25.02.14 - 1 X Aggarwal CaSR UK 01.04.14

Irfete Fetahu Multifaceted Oxford University, 8.01.2014 – 1 X CaSR UK 31.01.2014

Samawansch Multifaceted Cardiff University, 07.04.14 - 1 X a Tennakoon CaSR UK 09.05.14

Valerie Multifaceted Oxford University, 2 months 1 X Babinsky CaSR UK

1.1.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Erika Jensen-Jarolim University of Veterinary Medicine, Deputy member of Senate Vienna

Erika Jensen-Jarolim WWTF (Vienna Science and Board of trustees Technology Fund) , Vienna, Austria

Erika Jensen-Jarolim Lower Austria Steering Committee for the Research Strategy of Lower Austria

Erika Jensen-Jarolim RotePfote – Cancer Research for President until 08/2014 pets

Erika Jensen-Jarolim European Academy of Allergy and Board of Interest Group for Clinical Immunology Comparative and Veterinary Allergology

Erika Jensen-Jarolim European Academy of Allergy and Task Forces „Allergy Diagnosis“, Clinical Immunology „Biomarkers in Allergen Immunotherapy“ and chair of „AllergoOncology”

Erika Jensen-Jarolim Donau- University Krems Advisory Board, Center for Regenerative Medicine and Orthopedics

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

Member of commission for Erika Jensen-Jarolim Medical Univ. Vienna professorships, Applied Translational Radiobiology, Plastic surgery

1.1.8. Editorial Activities

Name Journal Function Erika Jensen-Jarolim World Allergy Organization Journal Deputy Chief-In Editor

Erika Jensen-Jarolim Journal of Biorepository Science for Associate Editor Applied Medicine, Dove Press

Erika Jensen-Jarolim Wiener Med. Wochenschrift Editor

Erika Jensen-Jarolim Int. Archs Allergy & Immunology Editor

Erika Jensen-Jarolim Allergo Journal Editor

Erika Jensen-Jarolim Immunology Letters Editor

Erika Jensen-Jarolim The Open Allergy Journal Editor

Erika Jensen-Jarolim Cancer Immunology, Immunotherapy Editor

1.1.9. Reviewing Activities

Ad hoc reviewing Grants/Thesis/Habilitation Jensen-Jarolim E Tumor Biology

Jensen-Jarolim E Allergy

Jensen-Jarolim E FEBS Letters

Jensen-Jarolim E Immunology Letters Food and Chem. Toxicology

Jensen-Jarolim E Foods

Jensen-Jarolim E PLOS one

Jensen-Jarolim E Journal of Allergy and Clinical Immunology

Jensen-Jarolim E Vaccine

Jensen-Jarolim E Cancer Immunology Immunotherapy

Jensen-Jarolim E J. of Immunology

Jensen-Jarolim E Scientific Reports

Jensen-Jarolim E Paediatric Allergy and Immunology

Jensen-Jarolim E Exper. Lung Research

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

Jensen-Jarolim E Frontiers on Biosciences

Jensen-Jarolim E Diploma thesis C. Belik

Jensen-Jarolim E Diploma thesis Schweiger

Jensen-Jarolim E Diploma thesis L. Hinterhölzl

Jensen-Jarolim E Diploma thesis H. Szöllösi

Jensen-Jarolim E Animal ethics application GZ: 354855/2013, March 20, 2014

Jensen-Jarolim E Animal ethics application GZ: 311633/2014, April 29, 2014

Jensen-Jarolim E Animal ethics application GZ: 806726/2014.1, July 15, 2014

Jensen-Jarolim E Animal ethics application GZ: 806726/2014.2, July 15, 2014

Jensen-Jarolim E Animal ethics application GZ: 806726/2014

Jensen-Jarolim E Habilitation Review G. Achatz-Straussberger

Jensen-Jarolim E w2 Professorship Lung Research

Jensen-Jarolim E w3 Professorship Exper. Asthma Research Fonds der Stadt Wien für innovative interdisziplinäre Krebsforschung – Jensen-Jarolim E Forschungsentwicklungspreis, Okt. 2014 Untersmayr-Elsenhuber E Journal of Allergy and Clinical Immunology

Untersmayr-Elsenhuber E Food and Chemical Toxicology

Untersmayr-Elsenhuber E Expert Review of Clinical Immunology

Untersmayr-Elsenhuber E Plos One

Kállay E Review for the EU: Horizon 2020 NCP 2014

Kállay E Review for the EU: Horizon 2020 MSCA Indiv. Fellowships 2014

Kállay E (International) Undergraduate Awards

Reviewer for the PhD thesis of Jussy Ryynänen, University of Eastern Kállay E Finland, Kuopio, Finland.

Reviewer of the Application of Dr. Sabina Seuter for the title of Docent in Kállay E the field of Molecular Biology at the University of Eastern Finland, Kuopio, Finland

Reviewer for a PhD Fellowship for the FWO (Research Foundation Kállay E Flanders)

Kállay E Reviewer for the Foundation against Cancer, Belgium

Kállay E Gutachter für die Nationalbank

Kállay E Gutachter für den Bürgermeisterfond

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

Kállay E Molecular Cellular Endocrinology

Kállay E Food And Chemical Toxicology

Kállay E Current Cancer Drug Targets

Kállay E Oncotarget

Kállay E Histopathology

Kállay E Journal Of Steroid Biochem. Mol. Biol. (3 Manuscripts)

Kállay E BMC Cancer

Kállay E FEBS Letters

Kállay E Current Neuropharmacology J.

Kállay E Cancer Medicine

Kállay E Clinical Colorectal Cancer

Kállay E Molecular Cancer

Kállay E Frontiers In Physiology

Kállay E Plos One

1.1.10. Filed and granted patents

Name Patent

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

1.1.11. Grants

Funding agency Title of project Principal investigator FWF (Austrian Comparing allergic mechanisms in Erika Jensen-Jarolim Science Fund), W humans & dogs to promote the 1248-B13, doctoral development of immunotherapeutical college MCCA – strategies. Molecular, Clinical and Cellular Allergology, part I. FWF (Austrian Cellular interactions decisive for immune Erika Jensen-Jarolim Science Fund), responses. W1205-B09 doctoral college, CCHD - Cell Communications in Health and Disease, part III FWF (Austrian Targeting ERbB-1 and ERbB-2 Erika Jensen-Jarolim Science Fund), overexpressed in cancer of dog by P23398-B19 passive immunotherapy with lgG versus lgE antibodies. FWF (Austrian Development of mimotope vaccines for Erika Jensen-Jarolim Science Fund), SFB preclinical and comparative medicine F4606-B19 studies. FP7-264663 The role of the Calcium Sensing Receptor Enikö Kallay (CaSR) in health and diseases, implications for translational medicine. WWTF FA648A0407 Dietary Vitamin Da powerful weapon in Enikö Kallay the war against colorectal cancer. Herzfelder’sche Modulating the Wnt-pathway in Enikö Kallay Familienstiftung Premalignant Colorectal Adenoma in AP00563OFF collaboration with B. Marian (Innere Med. I. Inst Cancer Research). FWF (Austrian Ca2+ signaling in BRAF-mutant tumors: Enikö Kallay Science Fund) therapeutic resistance and drug I1662-B13 combinations. FWF (Austrian S1P as a biomarker for food allergy. Eva Untersmayr- Science Fund), Elsenhuber APKLI284FW FWF (Austrian Microparticles for immunotherapy. Eva Untersmayr- Science Fund), Elsenhuber B21884-B11 Wirtschaftskammer, Einfluss von Proteinnitrierung auf Eva Untersmayr- FA648A1701 Allergien. Elsenhuber

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

1.1.12. Career Developments a) Habilitations: n = 1:

Erika Jensen-Jarolim: Franziska Roth-Walter, Habilitation in "Immunology", 2014

b) Habilitations in progress: n = 0

c) Professorships: n= 0

d) Qualification Agreement: n= 0

1.1.13. Teaching a) Bachelor students: n = 2

Erika Jensen-Jarolim

1. Sarah Meitz: Characterization of a canine anti-EGFR IgG antibody in immunohistochemistry (2013-ongoing)

2. Julia Satorina: Do hypoallergenic cats exist? - Secretion of Fel d 1 in the Neva Masquarade versus domestic cat breeds (2013)

b) Diploma, MDiploma and Master students: n = 8

Erika Jensen-Jarolim

1. MSc, Irene Fürdös: A phase I/II. clinical trial with a HER-2 AAVLP anti-cancer vaccine, (2014-ongoing)

2. MSc, Stefanie Wagner: Immunomodulatory properties of milk allergen Bos d 5, (2014 – ongoing)

3. MSc, Cornelia Belik: On the human side of animal experiments, (2013 – 2014)

4. MSc, Martina Muhr: Generation and characterization of a recombinant, soluble form of feline FceRI alpha for chip diagnosis of cat allergy (2013 – 2014)

Enikö Kallay

1. MSc, Maximilian Prinz-Wohlgenannt: Impact of the Extracellular Calcium-Sensing Receptor in Regulating Proliferation and Differentiation of Normal and Neoplastic Intestinal Cells (start 2013 – 08/2014) University of Vienna

Eva Untersmayr-Elsenhuber

1. MSc, Katharina Beitl: Functionalized allergen-loaded PLGA microparticles for oral immunotherapy of type I food allergy in a murine food allergy model of oral

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

immunizations under gastric acid suppression (start 2013 – 12/2014) University of Vienna

2. MSc, Anna Ondracek: The immunostimulatory capacity of nitrated food proteins (start 2013 – ongoing) University of Vienna

3. MSc, Sarah Exenberger: The impact of immunomodulating substances on intestinal epithelial cells (start 2014 – ongoing) University of Vienna

c) PhD, MDSci, MD students: n = 13

Erika Jensen-Jarolim

1. PhD, Lukas Einhorn: Recombinant species-specific FcεRIα for molecular diagnosis and comparative study of allergic diseases in veterinary patients, (2013 – ongoing)

2. PhD, Helen Szöllösi: Protamine based nanoparticles with CpG-oligodeoxynucleotides as a suitable carrier system for the induction of a TH1 mediated immune response, (2013 – 2014)

3. PhD, Jelena Gotovina: The role of Lipokalins in stress responses, (2013 – ongoing)

4. PhD, Judit Fazekas: Alternative concepts for immunotherapy of cancer, (2013 – ongoing)

5. PhD, Oida Kumiko: Nuclear factor- resistance against endocrine therapy of human breast cancer cells, (2012 – 2014)

6. PhD, Singer Josef: The role of IgE in cancer and allergy, (2010 – 2014)

7. PhD, Caroline Stremnitzer: Molecular characteristics and biology of house dust mite allergens Der p1 and 2, (2010 – 2014)

8. PhD, Jordakieva Galateja: Blood cell dynamics after respiratory challenge of sensitized patients, (2012 – ongoing)

Enikö Kallay

1. PhD, Abhishek Aggarwal: Calcium-Sensing Receptor: A Target for Colorectal Cancer

2. PhD, Doris Hummel: Vitamin D and Vitamin D Hydroxylases in Colonic Inflammation and Cancer

3. PhD, Irfete Fetahu: Epigenetic regulation of the calcium-sensing receptor expression in colorectal cancer

4. PhD Samawansha Tennakoon: Ligand-dependent signalling through the calcium sensing receptor in colon cancer.

5. PhD Charlotte Gröschel: The role of vitamin D in the prevention of colorectal cancer

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

1.1.14. Exams a) Oral examinations: n = 3

Erika Jensen Jarolim: Rigorosen old Medical Curriculum June 23, 2014 - Sadek Mohamed June 05, 2014 - Fellecke Petja

Eva Untersmayr-Elsenhuber: June 25, 2014 – S. Klapprodt

b) Diploma and Thesis-Examinations: n= 10

Erika-Jensen-Jarolim: November 28, 2014 - H. Szöllösi November 28, 2014 - A. Schoos October 24, 2014 - C. Belik June 28, 2014 - J. Singer June 28, 2014 - K. Oida June 25, 2014 - C. Stremnitzer April 30, 2014 - M. Muhr

Enikö Kallay: March 7. 2014 - J. Höbaus Mai 12, 2014 - D. Hummel August 6, 2014 - I.S. Fetahu

c) Exam supervising: n= 0

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

1.1.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2014 Jensen-Jarolim5 Erika 2.00 0.67 648010 Progress Report in Comparative Allergology, Oncology and Immunology Jensen-Jarolim Erika 5.00 5.00 648031 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Jensen-Jarolim Erika 2.00 0.67 860059 TS: New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 2.00 0.35 860079 JC New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 2.00 0.05 860919 CCHD Journal Club - SS 2014 Jensen-Jarolim Erika 2.00 0.11 861007 MCCA Journal Club Kallay Enikö 1.00 0.33 860021 Creative and critical Journal Club Kallay Enikö 2.00 0.67 860059 TS: New Developments and comparative aspects in allergology, oncology and immunology Kallay Enikö 2.00 0.23 860550 Basic Seminar Malignant Diseases II Kallay Enikö 2.00 0.67 648010 Progress Report in Comparative Allergology, Oncology and Immunology Pfanzagl Beatrix 2.27 2.00 802001 BL 4 - Funktionssysteme und biologische Regulation Pfanzagl Beatrix 2.27 4.43 802001 BL 4 - Funktionssysteme und biologische Regulation Untersmayr- Elsenhuber Eva 2.00 0.66 648010 Progress Report in Comparative Allergology, Oncology and Immunology Untersmayr- Elsenhuber Eva 5.00 2.50 648031 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Sum 18.34

WS 2014/15 Jensen-Jarolim Erika 2.00 0.18 562019 BVo: Immunologie Jensen-Jarolim Erika 5.00 2.50 648013 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Jensen-Jarolim Erika 2.00 0.67 648802 Progress Report in Comparative Allergology, Oncology and Immunology Jensen-Jarolim Erika 2.00 0.33 860060 JC New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 4.00 0.31 860116 Basic Seminar: CCHD - WS 2014 Jensen-Jarolim Erika 6.00 0.23 860586 TS: CCHD Doctoral Seminar - WS 2014 Jensen-Jarolim Erika 2.00 0.15 860926 JC: CCHD - WS 2014 Jensen-Jarolim Erika 2.00 0.13 861007 MCCA Journal Club Kallay Enikö 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen

5 The teaching courses that E. Jensen-Jarolim held at the partner university Vetmeduni Vienna, are not listed here. 36

Performance Report 2014 – Division 1 Comparative Immunology and Oncology

Kallay Enikö 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Kallay Enikö 5.80 0.13 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Kallay Enikö 2.20 0.80 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Kallay Enikö 1.00 0.34 860001 Creative and critical Journal Club I Kallay Enikö 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology Kallay Enikö 2.00 0.20 860966 Basisseminar: Zelluläre Signaltransduktion - WS 2014 Kallay Enikö 5.00 5.00 514051 Wachstumsregulation humaner Tumorzellen - (Wahlfachausbildung gem. § 13 StG) Kallay Enikö 2.00 0.67 648802 Progress Report in Comparative Allergology, Oncology and Immunology Pfanzagl Beatrix 2.00 2.00 803009 Problemorientiertes Lernen - 3. Semester Pfanzagl Beatrix 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen Pfanzagl Beatrix 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Untersmayr- Immunpathologische Laboratoriumstechnik - mit Demonstrationen (Wahlfachausbildung gem. Elsenhuber Eva 3.00 3.00 648011 § 13/1 lit. a StG) Untersmayr- Elsenhuber Eva 5.00 2.50 648013 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Untersmayr- Elsenhuber Eva 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology Untersmayr- Elsenhuber Eva 3.00 0.21 896019 Basics in Gender Medizin 1 Sum 23.39 Total sum SS+WS 41.37

Performance Report 2014– Division 2 Cellular and Molecular Pathophysiology

1.2. Division for Cellular and Molecular Pathophysiology Head: Peter Pietschmann, MD, Associate Professor

1. Publications6 IF Number Top/Std/Subst Isabella Ellinger 0.424 0.2 0/0/1 Renate Fuchs -- -- 0/0/0 Diana Mechtcheriakova 10.015 12 5/2/0 Peter Pietschmann 18.763 10.4 4/2/2 Theresia Thalhammer 10.323 5 1/3/0 Division-Sum 39.101 27.4 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Isabella Ellinger 1 10 3 Renate Fuchs 0 3 1 Diana Mechtcheriakova 2 3 1 Peter Pietschmann 1 3 6 Theresia Thalhammer 1 12 2 Sum 5 31 13

3. Teaching SS* WS* total W+S oral Exams Isabella Ellinger 5.49 7.78 13.27 0 Renate Fuchs 4.15 12.48 16.63 0 Diana Mechtcheriakova 1.06 0.86 1.92 0 Peter Pietschmann 6.62 4.36 10.98 1 Theresia Thalhammer 0.35 0.18 0.53 0 Jürg Graf 0.60 1.39 1.99 0 Sum 18.27 27.05 45.32

6 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 39

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.2.1. Publications a) Peer-reviewed original articles: n = 17

Nr. Article IF Class pro-rata IF 1. Singer, J., J. Fazekas , W. Wang, M. Weichselbaumer, M. 6.107 TOP 1.221 Matz, A. Mader, W. Steinfellner, S. Meitz, D. Mechtcheriakova, Y. Sobanov, M. Yillmann, T. Stockner, E. Spillner, R. Kunert, E. Jensen-Jarolim. Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. Mol Cancer Ther 2014; 13:1777-1790

2. Meshcheryakova, A., D. Tamandl, E. Bajna, J. Stift, M. 3.534 TOP 3.534 Mittlboeck, M. Svoboda, D. Heiden, S. Stremnitzer, E. Jensen-Jarolim, T. Grünberger, M. Bergmann, D. Mechtcheriakova. B cells and ectopic follicular structures: novel players in anti-tumor programming with prognostic power for patients with metastatic colorectal cancer. PLoS One 2014; 9:e99008

3. Köffel, R, A. Meshcheryakova, J. Warszawska, A. Henning, K. 9.775 TOP 1.955 Wagner, A. Jörgl, D. Gubi, D. Moser, A. Hladik, U. Hoffmann, MB. Fischer, W. van den Berg, M. Könders, C. Scheinecker, B. Gesslbauer, S, Knapp, H. Strobl. Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation. Blood 2014; 124:2713-2724

4. Slany, A, V. Paulitschke, V. Haudek-Prinz, A. 3.161 Std. 0.632 Meshcheryakova, C. Gerner. Determination of cell type- specific proteome signatures of primary human leukocytes, endothelial cells, keratinocytes, hepatocytes, fibroblasts and melanocytes by comparative proteome profiling. Electrophoresis 2014; 35:1428-1438

5. Slany, A., V. Haudek-Prinz, A. Meshcheryakova, A. Bileck, W. 5.001 TOP 1.002 Lamm, C. Zielinski, C. Gerner, J. Drach. Extracellular matrix remodeling by bone marrow fibroblast-like cells correlates with disease progression in multiple myeloma. J Proteome Res 2014; 13:844-854

6. Mirkina, I., E. Hradzijusufovic, C. Krepler, M. Mukula, D. 3.534 TOP 0.707 Mechtcheriakova, S. Strommer, A. Stella, E. Jensen-Jarolim, C. Höller, V. Wacheck, H. Pehamberger, P. Valent. Phenotyping of human melanoma cells revelas a unique composition of receptor targets and a subpopulation co- expressing ErbB4, EPO-R and NGF-R. PLoS One 2014; 9:e84417

7. Pils, D., A. Bachmayr-Heyda, K. Auer, M. Svoboda, V. Auner, 4.819 Std. 0.964 G. Hager, E. Obermayr, A. Reiner, A. Reinthaller, P. Speiser, I. Braicu, J. Sehouli, S. Lambrechts, I. Vergote, S. Mahner, A. Berger, D. Cacsire Castillo-Tong, R. Zeillinger. Cyclin E1 (CCNE1) as independent positive prognostic factor in advanced stage serous ovarian cancer patients – a study of the OVCAD consortium. Eur J Cancer 2014; 50:99-110

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

8. Rauner, M., U. Föger-Samwald, M.F. Kurz, C. Brünner- Kubath, D. Schamall, A. Kapfenberger, P. Varga, S. 4.461 Std. 4.461 Kudlacek, A. Wutzl, H. Höger, P.K. Zysset, G.P. Shi, L.C. Hofbauer, W. Sipos, and P. Pietschmann. Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture. Bone 2014; 64:281-287.

9 Föger-Samwald, U., J.M. Patsch, D. Schamall, A. 3.529 TOP 3.529 Alaghebandan, J. Deutschmann, S. Salem, M. Mousavi, and P. Pietschmann. Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures. Exp Gerontol 2014; 57:114-121

10. Gfrerer, L., V. Shubinets, T. Hoyos, Y. Kong, C. Nguyen, 3.328 TOP 3.328 Pietschmann P., C. Morton, R. Maas, E. Liao. Functional analysis of SPECC1L in craniofacial development and oblique facial cleft pathogenesis.Plast Reconstr Surg 2014; 134:748- 759

11. Dovjak, P., S. Dorfer, U. Föger-Samwald, S. Kudlacek, R. 2.681 Std. 2.681 Marculescu, P. Pietschmann. Serum levels of sclerostin and dickkopf-1: Effects of age, gender and fracture status. Gerontology 2014;60:493-501

12. Kocijan, R., C. Muschitz, A. Fahrleitner-Pammer, K. Amrein, 6.310 TOP 1.262 P. Pietschmann, J. Haschka, S. Dinu, S. Kapiotis, H. Resch. Serum sclerostin levels are decreased in adult patients with different types of osteogenesis imperfecta. J Clin Endocr Metab 2014;99:E311-319

13. Misof, B.M., J.M. Patsch, P. Roschger, C. Muschitz, S. 6.589 TOP 1.318 Gamsjäger, E.P. Paschalis, E. Prokop, K. Klaushofer, P Pietschmann, H. Resch. Intravenous treatment with ibandronate normalizes bone matrix mineralization and reduces cortical porosity after two years in male osteoporosis: A paired biopsy study. J Bone Miner Res 2014;29:440-449

14. Kisková, T. R. Jendželovský, E. Rentsen, A. Maier-Salamon, 2.764 Std. 2.764 N. Kokošová, Z. Papčová , J Mikeš, P. Orendáš, B. Bojková, P. Kubatka, M. Svoboda, K. Kajo, P. Fedoročko, W. Jäger, C. Ekmekcioglu, M. Kassayová, T. Thalhammer. Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. Eur J Cancer Prev 2014; 23:506- 513

15. Riha, J., S. Brenner, M. Böhmdorfer, B. Giessrigl, M. Pignitter, 4.909 TOP 4.909 K. Schueller, T. Thalhammer, B. Stieger, V. Somoza, T. Szekeres, W. Jäger. Resveratrol and ist major sulfated conjugates are substrates of organic anion transporting polypeptides (OATPs): impact on growth of ZR-75-1 breast cancer cells. Mol Nutr Food Res 2014; 58:1830-1842

16. Maier-Salamon, A., T. Thalhammer, G. Reznicek, M. 2.773 Std. 0.555 Böhmdorfer, I. Zupkó, A. Hartl, W. Jäger. Cytochrome P450 3A-mediated metabolism oft he topoisomerase I inhibitor 9- aminocamptothecin: impact on cancer therapy. Int J Oncol 41

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

2014; 45:877-886

17. Hamilton, G., L. Klameth, B. Rath, T. Thalhammer. Synergism 2.095 Std. 2.095 of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines. Molecules 2014; 19:2077-2088 sum 75.370 36.917

b) Invited Articles & Reviews with IF: n = 2

Nr. Article IF Class pro-rata IF 1. Pietschmann, P., U. Föger-Samwald, I. Ellinger K. Kerschan- 0.424 SSt. 0.424 Schindl. Entzündung und Knochenabbau: Rheumatoide Arthritis. Osteologie 2014; 3:173-178 2. Kerschan-Schindl K, Mikosch P, Obermayer-Pietsch B, Gasser 1.760 SSt. 1.760 RW, Dimai HP, Fahrleitner-Pammer A, Dobnig H, Roschger P, Preisinger E, Klaushofer K, Resch H, Pietschmann P. Current controversis in clinical management of postmenopausal osteoporosis. Exp Clin Endocr Diab 2014; 122:437-444 sum 2.184 2.184

c) Invited Articles & Reviews without IF: n = 3

Ellinger, I., P. Pietschmann. Editorial: Towards new targets for the diagnosis and treatment of malignant diseases: thematic issue dedicated to Theresia Thalhammer. Wien Med Wochenschr 2014; 164:447-449

Kurz H., Meran J.G., Pietschmann P. Professor Gerhart Hitzenberger zum 85. Geburtstag. Wien Med Wochenschr 2014; 164:499-502

Mungenast, F., T. Thalhammer. Estrogen biosynthesis and action in ovarian cancer. Front Endocrinol (Lausanne) 2014; 5(192):1-12

d) Book contributions: n = 9

1. Ellinger I and Ellinger A. Smallest Unit of Life: Cell Biology. In: Jensen-Jarolim E (ed) Comparative Medicine: Anatomy and Physiology. Springer Verlag Wien 2014, p. 19- 34

2. Aurich C and Ellinger I. Propagation: Mammalian Reproduction. In: Jensen-Jarolim E (ed) Comparative Medicine: Anatomy and Physiology. Springer Verlag Wien 2014, p. 195-217

3. Sipos W, Föger-Samwald U, Pietschmann P. Supporting apparatus of vertebrates: skeleton and bones. In: Jensen-Jarolim E (ed). Comparative Medicine – Anatomy and Physiology. Springer Verlag 2014, pp.35-44

4. Pietschmann P. Pathophysiologie des Alterns. In: Dorner TE (ed.) Public Health. Von den Gesundheitsbedürfnissen der Gesellschaft zu klinischen Implikationen. (MCW Block 22/23) , 2. Auflage, Facultas WUV 2014, pp. 253-256

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

5. Pietschmann P. Autoimmunendokrinologie. In: Ludvik B, Bischof M, Kraupp M, Luger A (eds). Endokrinologie und Stoffwechsel (MCW Block 10). Facultas 7. Auflage, Facultas Verlag 2014, pp. 18-25 6. Pietschmann P, Nanoff C, Dudczak R, Kainberger F, Marculescu R. Knochen- und Kalzium-Stoffwechsel, Erkrankungen der Nebenschilddrüse. In: Ludvik B, Bischof M, Kraupp M, Luger A (eds). Endokrinologie und Stoffwechsel (MCW Block 10).7. Auflage, Facultas Verlag 2014, pp. 206-222

7. Patsch J, Pietschmann P. Degenerative und altersassoziierte Erkrankungen. In: Marian B (ed). Krankheit, Krankheitsursachen und –bilder (MCW Block 8). Facultas 7. Auflage, Facultas Verlag 2014, pp.471-479

8. Ekmekcioglu C and Thalhammer T. Melatonin receptors and their role in human diseases. In: S. Venkataramanujam, Brzezinski A, Oter S, SD Shillcutt (eds): Melatonin and Melatonergic Drugs in Clinical Practice, Springer India 2014; p. 1-15

9. Föger-Samwald U, Alaghebandan A, Patsch JM, Schamall D, Salem S, Mousavi M, Pietschmann P. Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures. Bone Abstracts 2014; 3, p257

e) Abstracts, printed in periodicals: n = 22

Aggarwal A, Wohlgenannt M, Tennakoon S, Gröschel C, Meshcheryakova A, Baumgartner-Parzer S, Kallay E. The calcium-sensing receptor: a tumour suppressor in the colon. Journal für Mineralstoffwechsel 2014;21 (Sonderheft 1):2

Mechcheriakova D. B cells and ectopic lymphoid structures at tumor site: passengers, drivers and/or prognostic markers for clinical outcome? Int J Mol Med 2014; 34(1):25 Meeting Abstract: 184

Singer J, Fazekas J, Wang W, Weichselbaumer M, Matz M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, et al. Generation of canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. Mol Cancer Ther 2014; 13(7):1777-1790

Singer J, Fazekas J, Wang W, Weichselbaumer M, Matz M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, et al. IgE-based immunotherapy of cancer-A comparative oncology approach. Int J Mol Med 2014; 34(1):127, Meeting Abstract: 592

Ellinger I, Scheinast M, Pickem J, Voss A, Kemper J, Reiter M, Uher H, Zeisler H, Knöfler M, Salzer H, Gundacker C. System L Carrier: Are they involved in methylmercury (MEHG) toxicokinetics at the human materno-fetal barrier? Placenta 2014; 35(9): A109

Scheinast M, Pickem J, Voss A, Kemper J, Reiter M, Uher H, Zeisler H, Knöfler M, Salzer H, Ellinger I, Gundacker C. The GSH system: Is it involved in methylmercury (MEHG) toxicokinetics at the human materno-fetal barrier? Placenta 2014; 35(9): A110-A111

Molcan L, Svitok P, Stebelova K, Vesela A, Ellinger I, Zeman M. Different expression and localization pattern of MT1 melatonin receptor between conduit and resistant arteries can be involved in positive effects of melatonin on blood pressure control. ACTA Physiologica 2014; 211:51-52

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Föger-Samwald U, Alaghebandan A, Patsch J, Schamall D, Salem Sylvia, Mousavi Mehdi, Pietschmann P. Bone microarchitecture in men with osteoporotic hip fractures. Osteologie 2014; 23: 24 (P09)

Misof B, Patsch J, Roschger P, Muschitz C, Gamsjäger S, Paschalis E, Prokop E, Klaushofer K, Pietschmann P, Resch H. Intravenöse Ibandronat-Therapie normalisiert die Knochenmatrixmineralisation und reduziert die kortikale Porosität bei Männern mit Osteoporose. Osteologie 2014; 23: 35(P33)

Muschitz C, Dimai HP, Kocijan R, Resch H, Pietschmann P, Kostic M, Kaider A, Szivak M, Schilling M, Thaler HW. Atypical subtrochanteric fracture is a rare phenomenon in osteoporotic patients treated with bisphosphonates. JBMR 2014; Suppl.1

Pietschmann P, Weiss E, Föger-Samwald U, Thalmann M, Tsironi M, Skenderi K, Kerschan-Schindl K. Musculoskeletal effects of a 246-km ultramarathon race. JBMR 2014; Suppl.1

Weilner S, Schraml E, Wieser M, Messner P, Maier A, Redl H, Pietschmann P, Hackl M, Grillari-Voglauer R, Grillari J. Circulating microvesicles from elderly donors impact on osteogenic differentiation of mesenchymal stem cells. JBMR 2014; Suppl.1

Kienzl D, Fischer L, Gross T, DiFranco M, Weber M, Valentinitsch A, Jaksch P, Kleptko W, Marculescu R, Pietschmann P, Schueller-Weidekamm C, Kainberger F, Langs G, Patsch J. Non-invasive assessment of longitudinal changes in bone microarchitecture and bone strength over eighteen months in lung transplant recipients using high-resolution peripheral quantitative computed tomography (HR-pQCT). JBMR 2014; Suppl.1

Schneider J, Nebot E, Aparicio VA, Camiletti-Moirón D, Martinez R, Kapravelou G, Porres JM, López-Jurado M, Aranda P, Pietschmann P. Bone properties in rats under the effects of dietary amount and source of protein, high-intensity exercise and anabolic androgenic steroids administration. ACTA Physiologica 2014; 212: 54

Muschitz C, Kocijan R, Marterer C, Rahbar Nia A, Muschitz GK, Resch H, Pietschmann P. Sclerostin levels and severe changes in bone metabolism after bariatric surgery. Journal für Mineralstoffwechsel 2014; 21 (Sonderheft 1), 5

Weilner S, Schraml E, Wiesner M, Messner P, Maier AB, Redl H Pietschmann P, Grillari- Voglauer R, Grillari J. Donor age-dependent influence of circulating extra-cellular vesicles on in vitro bone formation. Journal für Mineralstoffwechsel 2014; 21 (Sonderheft 1), p. 7

Brenner S, Riha J, Schölm M, Buxhofer-Ausch V, Ausch C, Bajna E, Reiner-Concin A, Hamilton G, Klameth L, Thalhammer T. Specific OATP expression pattern in primary small cell lung cancer (Sclc) cell lines: impact on diagnosis and therapy. Drug Metabolism Reviews 2014; 45:243

Klameth L, Svoboda M, Thalhammer T, Olszewski U, Geissler K, Jäger W, Hamilton G. Expression of Ph regulatory proteins may influence drug resistance. Drug Metabolism Reviews 2014; 45:143

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Ausch CA, Zotter S, Sheikh M, Bauer H, Mollik M, Bajna E, Sebesta C, Reiner A, Thalhammer T. The role oft he organic anion transporting polypeptide OATP4A1 in immunactivation in colorectal cancer and inflammatory colon disease. J Clin Oncology 2014; 32:3

Riha J, Brenner S, Mungenast F, Sultan S, Grünsteidel J, Cacsire-Castillo-Tong D, Zeillinger R, Speiser P, Horvat R, Jäger W, Thalhammer T. Expression of organic anion- transporting polypeptides (OATP) 2a1, 4a1, 5a1 and 6a1 as possible biomarkers for human ovarian cancer. Drug Metabolism Reviews 2014; 45:242-243

f) Abstracts, in congress proceedings or abstract books: n = 28

Föger-Samwald U, Alaghebandan A, Patsch JM, Schamall D, Salem S, Mousavi M, Pietschmann P. Bone microarchitecture in men with osteoporotic hip fractures.(poster presentation) Osteologie 2014, München, Deutschland, March 13th -15th, 2014

Mungenast F., Aust S, Ocko K, Klameth L, Cacsire Castilo-Tong D, Zeillinger R, Van Gorp T, Vergote I, Braicu I, Sehouli J, Mahner S, Fogel M, Thalhammer T. Relevance of estrogen activating STS and inactivating SULT1E1 enzymes and estrogen receptors (ER) α/β in patients with advanced ovarian cancer. (poster presentation) 16th European Congress of Endocrinology, Wroclaw, Polen, May, 3rd-7th, 2014

Föger-Samwald U, Alaghebandan A, Patsch JM, Schamall D, Salem S, Mousavi M, Pietschmann P. Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures. (poster presentation) European Calcified Tissue Society Congress (ECTS), Prag, Tschechien, May 17th-20th, 2014

Gfrerer L, Shubinets V, Hoyos T, Kong Y, Nguyen , Pietschmann P, Morton C, Maas R, Liao E. Functional analysis of SPECC1L in craniofacial development and oblique facial cleft pathogenesis. (oral presentation) 10th YSA PhD-Symposium, Medical University of Vienna, June 12th, 2014 Scientific Program “Molecular Biology”, “Bones & Joints” No. 12, p 29

Klameth L, Redl M, Thalhammer T, Hamilton G. Effects of chemotherapy of small cell lung cancer on ph-regulating proteins. (poster presentation) 10th YSA PhD-Symposium, Medical University of Vienna, June 12th, 2014 Scientific Program “Molecular Biology”, Bones & Joints”, “Cancer” No. 165, p 33

Meshcheryakova A, Svoboda M, Heinze G, Bajna E, Pils D, Tong D, Jensen-Jarolim E, Birner P, Zeillinger R, Mechtcheriakova D. Prognostic power of sphingolipid-related multigene signature for patients with primary ovarian carcinoma. (poster presentation) 10th YSA PhD-Symposium, Medical University of Vienna, June 12th, 2014 Scientific Program “Molecular Biology”, Bones & Joints”, “Cancer”, No. 175, p. 34

Weilner S, Schraml E, Keider V, Schneider KH, Wassermann K, Redl H, Pietschmann P, Grillari J. Age-dependent influence of plasma derived extracellular vesicles on osteogenic differentiation capacity of mesenchymal stem cells. (poster presentation) 10th YSA PhD-Symposium, Medical University of Vienna, June 12th, 2014 Scientific Program “Molecular Biology”, Bones & Joints”, “Cancer”, No. 179, p. 34

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Föger-Samwald U, Rauner M, Kurz MF, Brünner-Kubath C, Kapfenberger A, Varga P, Höger H, Zysset PK, Shi GP, Sipos W, Pietschmann P. Effects of cathepsin S deficiency on bone turnover. (poster presentation) 10th YSA PhD-Symposium, Medical University of Vienna, June 12th, 2014 Scientific Program “Molecular Biology”, Bones & Joints”, “Cancer”, No. 183, p. 34

Uher H, Niederberger-Leppin V, Waltl E, Ellinger I, Fuchs R. Localization of rhinovirus and nutrient receptors in the nasal mucosa. (oral presentation) Virus-Cell Interactions, Seili, Finnland, August 18th – 20th, 2014, abstract book Gajdzik L, Ganjian H, Edlmayer J, Valenta R, Blaas D, Fuchs R. Distinct uncoating pathways of human rhinovirus types. (oral presentation) Early Events in Virus Infection, Ascona, Schweiz, August 25th – 28th, 2014, abstract book

Pietschmann P, Weiss E, Föger-Samwald U, Thalmann M, Tsironi M, Skenderi K, Kerschan-Schindl K. Musculoskeletal effects of a 246-km ultramarathon race. (poster presentation) ASBMR 2014 Annual Meeting, Houston, Texas, USA, September 12th –September 15th, 2014

Meshcheryakova A. Sphingolipid-related multigene signature improves risk prediction for patients with primary ovarian carcinoma. (poster presentation). CePII Center Retreat, Medical University of Vienna, September 16th, 2014, abstract book

Sener A, Maier A, Kuhn L, Seidelmann B, Huber M, Uher H, Molcan L, Zeman M, Ellinger I. Melatonin as an anti-hypertensive compound? Expression of melatonin receptor type 1 in perivacular fat tissue of mesenteric arteries (poster presentation) CePII Center Retreat, Medical University of Vienna, September 16th, 2014, abstract book

Klameth L, Redl M, Thalhammer T, Ellinger I, Hamilton G. Effects of chemotherapy of small cell lung cancer on PH regulating proteins. (poster presentation CePII Center Retreat, Medical University of Vienna, September 16th, 2014, abstract book

Gelles K, Uher H, Niederberger-Leppin V, Waltl E, Ellinger I, Fuchs R. Localization of rhinovirus and nutrient receptors in the nasal epithelium. (poster presentation CePII Center Retreat, Medical University of Vienna, September 16th, 2014, abstract book

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Ellinger I, Straka E, Scheinast M, Pickem J, Reiter M, Uher H, Zeisler H, Knöfler M, Salzer H, Gundacker C. GSH system related enzymes are involved in methylmercury (MeHg) toxicokinetics at the human maternofetal barrier. (poster presentation CePII Center Retreat, Medical University of Vienna, September 16th, 2014, abstract book

Elllinger I, Straka E, Scheinast M, Pickem J, Schatz J, Uher H, Grbic S, Hofer R, Zeisler H, Knöfler M, Salzer H, Gundacker C. System L carrier is involved in methylmercury (MeHg) toxicokinetics at the human maternofetal barrier. (poster presentation CePII Center Retreat, Medical University of Vienna, September 16th, 2014, abstract book Schneider J, Nebot E, Aparicio VA, Camiletti-Moirón D, Martinez R, Kapravelou G, Porres JM, López-Jurado M, Aranda P, Pietschmann P. Bone properties in rats under the effects of dietary amount and source of protein, high-intensity exercise and anabolic androgenic steroids administration. (poster presentation) XXXVII Congreso de la Sociedad Espanola de Ciencias Fisiologicas, Granada, Spanien, September 24th –September 26th,2014

Mechcheriakova D. B cells and ectopic lymphoid structures at tumor site: passengers, drivers and/or prognostic markers for clinical outcome? (oral presentation) 19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine, Athens, Greece, October 9th - October 11th, 2014

Meshcheryakova A, Svoboda M, Bajna E, Jensen-Jarolim E, Köfeler H, Mechtcheriakova D. Contribution of the sphingolipid-associated mechanisms to the process of epithelial to mesenchymal transition. (oral presentation) 19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine, Athens, Greece, October 9th - October 11th, 2014

Jungwirth C, Seebacher W, Gelles K, Gundacker C, Husano C, Rogojanu R, Steiner G, Ecker R, Dorffner G, Ellinger I. Automated immunofluorescence4 microscopy – validation of image segmentation and modelling of tissue variability of protein expression. (poster presentation) 7th Imaging in Life Science Workshop, Campus Science Support Facilities GmbH, Vienna, November 4th, abstract book

Aggarwal A, Wohlgenannt M, Tennakoon S, Gröschel C, Meshcheryakova A, Baumgartner- Parzer S, Kallay E. The calcium-sensing receptor: a tumour suppressor in the colon. (poster presentation) Wissenschaftliche Herbsttagung der Österreichischen Gesellschaft für Knochen und Mineralstoffwechsel, Vienna, November 14th – November 15th, 2014

Muschitz C, Kocijan R, Marterer C, Rahbar Nia A, Muschitz GK, Resch H, Pietschmann P. Sclerostin levels and severe changes in bone metabolism after bariatric surgery. (poster presentation) Wissenschaftliche Herbsttagung der Österreichischen Gesellschaft für Knochen und Mineralstoffwechsel, Vienna, November 14th – November 15th, 2014

Föger-Samwald U, Pietschmann P, Weiss E, Thalmann M, Tsironi M, Skenderi K, Kerschan-Schindl K. Increased dickkopf-1 and follistatin serum levels after 246-km ultramarathon race. (poster presentation) Wissenschaftliche Herbsttagung der Österreichischen Gesellschaft für Knochen und Mineralstoffwechsel, Vienna, November 14th – November 15th, 2014

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Weilner S, Schraml E, Wiesner M, Messner P, Maier AB, Redl H Pietschmann P, Grillari- Voglauer R, Grillari J. Donor age-dependent influence of circulating extra-cellular vesicles on in vitro bone formation. (poster presentation) Wissenschaftliche Herbsttagung der Österreichischen Gesellschaft für Knochen und Mineralstoffwechsel, Vienna, November 14th – November 15th, 2014

g) Teaching Scripts and Books: n = 0

h) Articles in Medical Journals: n = 0

i) Public activity: n = 12

Isabella Ellinger:

Scientific education for kids:

Interview: „Gummibärchen mit Rückstoß und blaues Rotkraut“ Forschen und experimentieren wie Daniel Düsentrieb, Die Ö1 Kinderuni, 23.2.2014, 17:10 Uhr

Vorlesung „Cell City – was geht ab in der Zelle“ (Isabella Ellinger mit Adolf Ellinger, Zellbiologie & Ultrastrukturforschung). Lange Nacht der Forschung, Wien, 4.4.2014

Informationsstand „Vom Lesestein zum modernen Mikroskop: Mikroskopische Forschung und Lehre im digitalen Zeitalter“ (Isabella Ellinger, Adolf Ellinger, Zellbiologie & Ultrastrukturforschung, Rupert Ecker, TissueGnostics GmbH), Lange Nacht der Forschung, Wien, 4.4.2014

Informationsstand „Quecksilber: von Alchemie und Industrie. Wie der Mensch die Umwelt beeinflußt und dadurch sich selbst gefährdet (Claudia Gundacker, Institut für Medizinische Genetik & Isabella Ellinger), Lange Nacht der Forschung, Wien, 4.4.2014

Vorlesung „Cell City – was geht ab in der Zelle“ (Isabella Ellinger und Adolf Ellinger), Kinderuni Wien, 16.7.2014

Vorlesung „Was tut Daniel Düsentrieb? So werkt ein Forscher“ (Isabella Ellinger und Ursula Föger-Samwald) Kinderuni Wien, 18.7.2014

Peter Pietschmann:

Expertentipp Pietschmann P. „Habe ich Osteoporose?“ Wohlsein – Das Österreichische Wohlfühlmagazin, Ausgabe 1/14, 2014, Seite 3

Interview Pietschmann P. „Osteoporose ist eine immunologische Erkrankung“ Apothekerkrone 9/2014, Seite 30

Interview Pietschmann P. „Osteologische Grundlagenforschung: Die Osteoporose ist eine immunologische Erkrankung“, Universum Innere Medizin 03/2014, Seite 48

Interview Pietschmann P. „Osteoporose ist eine immunologische Erkrankung“, Ärzte Krone 9/2014; Seite 14

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Pressemeldung: „Diabetes knabbert an den Knochen“, Medical Tribune, 48, 2014, Seite 36

Pressemeldung:“Rheuma hat viele Gesichter – manchmal auch ganz seltene“, Jatros – Orthopädie & Rheumatologie 4/14, Seite 64

1.2.2 Research Awards: n = 1

Ursula Azizi-Semrad:

L’Oreal Stipendium “for women in science”, “Age-related differences in vitamin D3 effects on functional T helper cell differentiation”, 4.7.2014

1.2.3 Invited lectures: n = 28

Isabella Ellinger:

1. IgG transport across the human placenta, Tissue FAXS Workshop at the Romanian Academy, Institute of Biochemistry, Bukarest, Rumänien, 20.5.2014

2. Blood pressure modulation by melatonin: localization of melatonin receptor 1 in the mesenteric artery wall. New Frontiers in Basic Cardiovascular Research 2014, 11th meeting of France – New EU members, Bratislava, Slowakei, 17.6.2014

3. Quantitative immunohistochemistry and automated image analyses in research and diagnosis. Workshop “Data Science for Personalized Medicine”, MUW Wien, 16.12.2014

Renate Fuchs:

4. Localization of rhinovirus and nutrient receptors in the nasal mucosa. Virus-Cell Interactions, Seili, Finnland, 18.8.2014

5. Distinct uncoating pathways of human rhinovirus types. Early Events in Virus Infection, Ascona, Schweiz, 28.8.2014

6. Distinct uncoating pathways of human rhinovirus types. University of Jyväskylä, Finnland, 30.10.2014

Lisa Gfrerer:

7. Functional analysis of SPECC1L in craniofacial development and oblique facialcleft pathogenesis. 10th YSA PhD-Symposium, Medical University of Vienna, Wien, June 12th, 2014

Diana Mechcheriakova:

8. B cells and ectopic lymphoid structures at tumor site: passengers, drivers and/or prognostic markers for clinical outcome? 19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine, Athen, Griechenland, 8.10.2014

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Anastasia Meshcheryakova:

9. Contribution of the sphingolipid-associated mechanisms to the process to mesenchymal transition. 19th World Congress on Advances in Oncology and 17th Internatinal Symposium on Molecular Medicine, Athen, Greece, 9.-11.10.2014

10. Patient-specific immunological imprint within complex ovarian cancer tissues. The 2014 annual meeting of the Austrian Society for Allergology and Immunology (ÖGAI 2014), Salzburg, Austria, 6.-8.11.2014

Peter Pietschmann:

11. Pathophysiologie der renovaskulären Knochenerkrankung. NephroForum, Klinische Abteilung für Nephrologie und Dialyse Wien, 7.1.2014

12. Die Pathophysiologie der Osteoporose. Osteoporose 2014 – „News and Developments“ . Gesellschaft der Ärzte – Billrothaus, Wien, 8.1.2014 13. Morbus Paget. Rheuma Days, Urania, Wien, 1.3.2014

14. Die männliche Osteoporose. Interdisziplinärer Kongress „Mann + Gesundheit“, Tagungszentrum Schloß Schönbrunn, Wien, 1.3.2014

15. Osteoporose – eine entzündliche Erkrankung? Osteologie 2014, München, 14.3.2014

16. Osteoimmunologie. Conference Days 2014 (MSD), St. Wolfgang, 5.4.2014

17. Osteoporose – eine immunologische Erkrankung!? 22. Osteoporoseforum, St. Wolfgang, 10.5.2014

18. Osteoimmunology. Seminar „Osteoimmunology“, Bernhard Gottlieb University Clinic of Dentistry, Wien, 3.6.2014

19. Osteoporosis – an inflammatory disease? 4. International Scientific and Educational Symposium fo Bioregenerative Medicine, Slovakia, 17.9.2014

20. Osteoimmunologie – Pathophysiologie und Einteilung der Allergie, Internationales Symposium Implantatassoziierte Allergie – Mythos oder Wahrheit?, Wien, 26.9.2014

21. Metabolische Knochenerkrankungen beim geriatrischen Patienten. 6. Masterlehrgang Geriatrie 2014/2015, Haus der Barmherzigkeit Wien, 5.11.2014

22. Osteolipidologie. Wissenschaftliche Herbsttagung der ÖGKM 2014, KH der Barmherzigen Schwestern, Wien, 14.11.2014

23. Diabetes and bone. Ärztefortbildung für Firma Eli Lilly GmbH, Evangelisches Krankenhaus, 1180 Wien, 20.11.2014

24. Labordiagnostik in der Osteologie, Ärztliche Fortbildung des Klinischen Institutes für Labormedizin, MUW Wien, 11.12.2014

25. Osteoporose: eine immunologische Erkrankung. Fortbildungstag – Menopausekongress, Wien, 12.12.2014

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Theresia Thalhammer:

26. Estrogen-related enzymes and transmembrane transporters in cancer of ovary, colon and lung. BIT’s 7th Annual World Cancer Congress 2014, China, May 16th, 2014

27. The role of solute transporters in the cellular accumulation of drugs and hormones in cancer cells. Khon Kaen University, Faculty of Pharmaceutical Sciences, Thailand, July 2014 28. Transmembrane transporters from the OATP family have an important role in cancer therapy. 131. Predavanje SBD Seminar an der Medizinischen Fakultät der Universität Ljubljana, Slovenien, 16.10.2014

1.2.4 Congress organization

Division National congress Intern. congress, member Name: Name, date Function Name, date Function Renate Fuchs AIROPico, Kick-off Scientific Board Meeting, Amsterdam, Member Holland, 28.1.- 29.1.2014 Renate Fuchs AIROPico Meeting and Scientific Board IPR Workshop, Member Helsinki, Finnland, 26.11.2014-27.11.2014 Peter Forum für Geriatrie Organising Pietschmann und Gerontologie, comitee Bad Hofgastein, 13.- 16.3.2014 Peter 19. Jahrestagung der Session Pietschmann Österreichischen chair Gesellschaft für Endokrinologie und Stoffwechsel (ÖGES) Billrothhaus Wien, 3.- 4.4.2014 Isabella Ellinger 15th WISIA Co- Symposium, 23.- organisation 24.5.2014 Peter Wissenschaftliche Co- Pietschmann Herbsttagung der president Österreichischen Gesellschaft für Knochen und Mineralstoffwechsel (ÖGKM) 2014, 14.- 15.11.2014 Theresia Workshop on drug Co-organisation Thalhammer metabolism and interaction: in vitro and in silico to in vivo, Khon Kaen University, 1.- 31.7.2014

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.2.5. Hosting speakers

division member Speaker´s name Affiliation Date Peter Pietschmann Johannes Grillari, Universität für Bodenkultur, Institut 10/01/2014 PhD, Assoc. Prof. für Angewandte Mikrobiologie Theresia Tea Lanisnik University of Biochemistry, Medical, 02/04/2014 Thalhammer Rizner, PhD, Faculty, Institute of Biochemistry, Assoc. Prof. Ljubljana, Slovenia Isabella Ellinger Mirjam Lutz, MSc Clinical Department of 04/04/2014 Neurosciences, Medical University of

Vienna Diana Philip ETH Zürich / Nebion AG, Switzerland 03/09/2014 Mechtcheriakova Zimmermann, PhD

1.2.6 Mobility

Name Program University, Time frame Division In Out country Ellinger Isabella/ WTZ – Austria Comenius 1.1.2013 – IE x x Michel Zeman /Slovakia University, Faculty 31.1.2015 of Sciences, Department of Animal Physiology and Etology, Bratislava, Slowakia Molcan Lubos WTZ – Austria Comenius 4.6.- IE X /Slovakia University, Faculty 31.12.2014 of Sciences, Department of Animal Physiology and Etology, Bratislava, Zidlikova Katarina WTZ – Austria Comenius 4.6.- IE X /Slovakia University, Faculty 31.12.2014 of Sciences, Department of Animal Physiology and Etology, Bratislava, Mekkova Maria Ernst-Mach- Pavol Jozef 17.2.- TT x Stipendium der Săferik 19.2.2014 Aktion Österreich- Universität, Slowakei Košice, Animal Physiology, Slowakia Kiskova Terezia Ernst-Mach- Pavol Jozef 17.2.- TT x Stipendium der Săferik 19.2.2014 Aktion Österreich- Universität, Slowakei Košice, Animal Physiology, Slowakia Thalhammer Visiting Professor Khon Kaen 1.7.- TT x Theresia Program 2014 University, 31.7.2014 Thailand

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.2.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Peter Pietschmann Habilitationskommission Mitglied der Kommission “konservativ” (Interne, Pädiatrie, Dermatologie, Radiologie)

1.2.8. Editorial Activities

Name Journal Function Isabella Ellinger Wiener Medizinische Guest editor Wochenschrift Member Editorial Board Peter Pietschmann Wiener Medizinische Associate Editor Wochenschrift

Peter Pietschmann Hormone Metabolic Research Member Editorial Board Peter Pietschmann Zeitschrift für Gerontologie und Member Editorial Board Geriatrie Peter Pietschmann Journal für Mineralstoffwechsel Member Editorial Board Theresia Thalhammer Journal of Biochemistry and Member Editorial Board Molecular Biology Research

1.2.9. Review Activities

Name Grants/Thesis/Habilitation Theresia Thalhammer Czech Science Foundation – Project Proposal No. 15-153745 by Doc.RNDR. Petr Mlejnek (grant) Diana Mechtcheriakova The British Lung Foundation – Research Grant

1.2.10. Filed and granted patents

Name Patent

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.2.11. Grants

Funding agency Title of project Principal investigator Wissenschaftlich- Melatonin und Blutdruckkontrolle: Kooperationsprojekt: Prof. Technische Identifizierung und Charakterisierung von Michal Zeman Comenius Zusammenarbeit Melatonin-Rezeptoren in Rattengefäßen University Bratislava (WTZ) Österreich – (Projektleiter) and Slowakei Isabella Ellinger SK-AT- 06-2013 Forschungsförderungs Melatonin / Blutdruck 1 - generation Isabella Ellinger gesellschaft (FFG) innovation Praktika (Talente-Praktika für FA648A1015 Schülerinnen und Schüler. Forschungsförderungs Melatonin / Blutdruck 2 - generation Isabella Ellinger gesellschaft (FFG) innovation Praktika (Talente-Praktika für FA648A1014 Schülerinnen und Schüler. Forschungsförderungs Melatonin / Blutdruck 3 - generation Isabella Ellinger gesellschaft (FFG) innovation Praktika (Talente-Praktika für FA648A1015 Schülerinnen und Schüler. Tissue Gnostics GmbH Validierung der Segemtierung bei der UE64801008 automatischen quantitativen Immunhistochemie: Einfluss der Inter-Rater- Variabilität auf die in-situ-Quantifizierung von Proteinen in plazentaren Synzytiotrophoblasten und fötalen Endothelzellen. Felix Bronner Local gene expression in bone samples from Ursula Föger-Samwald Dissertations- eldery women with osteoporotic hip fractures. stipendium AP00604OFF FWF – Der AID-gene regulatory network in cancer. Diana Mechtcheriakova Wissenschaftsfonds APP22441FW FWF – Der Sphingolipid-related genes in cancer. Diana Mechtcheriakova Wissenschaftsfonds APP23228FW Springer Verlag GmbH Unterstützung er Errichtung und Betreibung Peter Pietschmann AP00243OFF eines Editorial Office für die Wiener Medizinische Wochenschrift und der Publikationstätigkeit der Arbeitsgruppe Knochen-, Gender- und Altersforschung Roche Austria GmbH Errichtung eines Forschungsnetzwerks auf Peter Pietschmann AP00369OFF dem Gebiet der Gerontologie. MSD – Merck, Sharp & Cathepsin K in Osteoimmunology. Peter Pietschmann Dohme FA648A0604 Novartis Pharma Bone, Gender und Aging Research. Peter Pietschmann GmbH FA6480606 Mag. Ursula Föger- Gene expression in elderly women. Peter Pietschmann Samwald AP00570OFF Amgen Entwicklung und Validierung einer Peter Pietschmann FA648A0608 automatisierten Methode zur Feststellung von Sclerostin im Mausknochen.

Eli Lilly Pathogenesis of fractures in diabetes mellitus. Peter Pietschmann FA648A0609 Fresenius Kabi Austria Automated Cell Detection in Peter Pietschmann GmbH Osteoimmunology. FA 648A0610 54

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Medahead Bone, Gender and Aging Research. Peter Pietschmann FA648A0611 MEDA Pharma GmbH Gezielte Osteoporosetherapien für ältere FA648A0612 postmenopausale Frauen. Österreichische Primary hyperparathyroidism. Cooperation Peter Nationalbank Pietschmann with Dr. AP13245ONB Katharina Kerschan-Schindl (project leader) Medizinisch Identifikation und Validation therapeutischer Principle Investigator: T. Wissenschaftlicher Targets beim kleinzelligen Lungenkarzinom. Thalhammer (Cooperation: Fonds des Univ.Prof.Dr. Primar Klaus Bürgermeisters der Geissler, Ludwig Boltzmann Stadt Wien Institut, KH Hitzing, 5. Med. Nr. P110016 Abt. mit Onkologie Ludwig-Boltzmann Investigation of genetic and molecular Principle Investigator: T. Institut für biological characteristics of the tumor cells.... Thalhammer Translationale Koordinator Prof. Robert Onkologie Zeillinger, Prof. G. Hamilton

1.2.12. Career Developments a) Habilitations: n = 0

b) Habilitations in progress: n = 0

c) Professorships: n =0

1.2.13. Teaching a) Bachelor students: n =5

Isabella Ellinger:

Redl Marlene: BSc Molekulare Biotechnologie. Modulation von pH-regulierenden Mechanismen in Krebszellen. (01/2014-05/2014)

Diana Mechtcheriakova:

Maxymovitz Eva: BSc Molekulare Biotechnologie. Microscopy-based qualitative and quantitative analysis of complex ovarian carcinoma tissue. (01/2014-05/2014)

Teuchmann Hannah Luise: BSc Molekulare Biotechnologie. Real-time PCR-based profiling approach to uncover the role of sphingolipid machinery within epithelial to mesenchymal transition process. (01/2014- 05/2014).

Peter Pietschmann:

Weiss Elisabeth: BSc Biomedizinische Analytik. Muskulo-skeletale Effekte des Spartathlon-Laufes. (01/2014- 07/2014). 55

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Theresia Thalhammer:

Fischer Melanie: BSc Biology. Nachweis von CD45+ Leukozyten an Kolonkarzinomschnitten mittels IHC. (01/2014-04/2014).

b) Diploma, MDiploma and Master students: n =31

Renate Fuchs:

Jalali Manuel: MDiploma Thesis. Mechanismus von Virusinfektionen: Einfluß von Ethylisopropylamilorid auf die Infektion von HRB89. (07/2011 – 11/2014). Medical University of Vienna

OTTO Julian: MDiploma Thesis: Rolle der Clathrin-abhängigen Endozytose im Infektionsmechanismus des humanen Rhinovirus 89 (06/2012 – in progress), Medical University of Vienna Spanberger Thomas: MDiploma Thesis. Mechanismus von Virusinfektionen. (05/2009 – in progress), Medical University of Vienna.

Isabella Ellinger:

Habringer Pia: MDiploma Thesis: Studying the effects of the RAGE-ligands advanced glycation end products (AGEs) on the expression level of the RAGE-variants full length RAGE and soluble RAGE (flRAGE and sRAGE) in trophoblast-like BeWo cells. (05/2012 – 05/2014) Medical University of Vienna

Jungwirth Christoph: MDiplomaThesis: Validierung der Segmentierung bei der automatischen quantitativen Immunhistochemie: Einfluss der Inter-Rater-Variabilität auf die in situ-Quantifizierung von Proteinen im plazentaren Endothelzellen. (09/2014 – in progress) Medical University of Vienna

Kemper Jost: MDiploma Thesis: Mercury transport across the placental barrier: Expression and localization of OAT4 (05/2013 – in progress ) Medical University of Vienna

Maier Andreas: PharmDiploma Thesis: The role of melatonin in blood pressure modulation – characterization of specificity of anti-melatonin receptor 1 (MT1) antibodies. (03/2014- 12/2014)

Mytsko Yuliya: Master Biology: Localization of the neonatal IgG Fc-receptor (FCRN) in the sycytiotrophoblast and fetal endothelial cells of human term placental chorionic villi in situ and in isolated placental endothelial cells ((05/2013-08/2014) University of Vienna

Reiter Martin: MDiploma Thesis: Quecksilbertransport über die Plazentaschranke. Untersuchung der Funktion der Kandidatenproteine MRP 1 – 5 (ABCC 1 – 5) und OATP 4 (SLC22A11) mittels Knockdown-Versuchen in HepG2 und fetalen Fruchtwasserstammzellen (07/2013 – in progress) Medical University of Vienna

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Schaffhauser Martin: MDiploma Thesis. Investigating the contribution of the receptor for advanced glycation end products (RAGE) to the gestational disorder pre-eclampsia: do RAGE-ligands S100 calcium- binding and High Mobility Group Box 1 affect the expression of RAGE-protein variants flRAGE and sRAGE in trophoblast-like BeWo cells? (05/2012 – in progress) Medical University of Vienna

Seebacher Wolfgang: MDiploma Thesis. Validierung der Segmentierung bei der automatischen quantitativen Immunhistochemie: Einfluss der Inter-Rater-Variabilität auf die in situ-Quantifizierung von Proteinen im plazentaren Synzytiotrophoblasten.(09/2014 – in progress) Medical University of Vienna

Sener Arife: Master Molekulare Biotechnologie: Exploring the involvement of rat adipocytes in blood pressure modulation by melatonin. (04/2014 – in progress) FH Campus Vienna

Voss Agnes: MDiploma: Quecksilbertransport über die Plazentaschranke: Expression und Lokalisation von MRP2. (05/2013 - in progress) Medical University of Vienna

Diana Mechtcheriakova:

Wöhrer Susanne: DiplomaPharm:The TissueFAXS-based algorithm to assess the prognostic significance of tumor-infiltrating immune cells in ovarian carcinoma (03/2012- 03/2014) University of Vienna

Scharf Elfi: DiplomaPharm: The distribution pattern and prognostic power of tumor-infiltrating macrophages in ovarian carcinoma (10/2012- 01/2014) University of Vienna

Kaufmann Tamara: DiplomaPharm: Activation-induced cytidine deaminase (AID): potential novel biomarker and/or target during epithelial-to-mesenchymal transition program in cancer. (03/2011- 06/2014). University of Vienna

Peter Pietschmann:

Körbler Florian: MDiploma thesis: Der Einfluss des Makrophagen-Kolonie-stimulierenden-Faktors (M-CSF) auf die Frkaturheilung durch Stimulation der Osteoklasten. (7/2013 – in progress) Medical University of Vienna

Lamm Christiane: Diploma Biology: Mikro-CT Analyse morphologischer Strukturveränderungen bei Osteomyelitis anhand historischer Präparate aus dem „Narrenturm (02/2013 – in progress) University of Vienna

Umar Zahra: MDiploma: Wirkung von Osteoprotegerin-Fc auf Knochenstruktur und Knochenumbau beim Schwein (Sus scrofa) (08/2012 05/2014). Medical University of Vienna

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Theresia Thalhammer:

Ackermann Isabel: DiplomaPharm. Carboanhydrase IX und pH Regulation im Ovarialkarzinom. (05/2014 – in progress) University of Vienna

Bolis Marian: DiplomaPharm. Expression von OATP-Transportproteinen in Ovarial-Karzinomproben: Bedeutung für die Tumortherapie. (03/2014 – in progress) University of Vienna

Durmaz Yasemin: DiplomaPharm. Expression von Enzymen und Transportproteinen in Tumorzellen und Geweben: Bedeutung für die Therapie. (09/2011 –in progress). University of Vienna

Eric Branislava: Diploma Biology: Relation between Abcg2 transporter expression and NOTCH-1 in solid tumors (liver, lung, ovary) (05/2013 – in progress) University of Vienna

Ganster Michaela: DiplomaPharm. PH-regulatorische Mechanismen in Ovarialkarzinomzelllinien. (09/2014 – in progress) University of Vienna Geissler Nora: Diploma Biology. Überexpression von GLI-1 bei Lebertumoren. (02/2013 – in progress) University of Vienna

Katic Ana: Diploma Pharm: Expression von OATPs in Lungenkarzinomzellinien (09/2013 – 06/2014) University of Vienna

Larijani Aida: DiplomaPharm: OATP Transporter in soliden Tumoren. (03/2012 – in progress) University of Vienna

Mungenast Felicitas: Diploma Biology: Organic anion transporting polypeptides as potential tumor markers in ovarian carcinoma (03/2013 – 06/2014) University of Vienna

Ocko Katharina: DiplomaPharm: Expression von OATPs in Tumorproben von Patienten (09/2013 – 06/2014) University of Vienna

Sheikh Maidah: DiplomaPharm: Expression von OATP-Transportern im Tumorgewebe: Einfluß auf die Therapie (05/2013 – 12/2014) University of Vienna

Zhang Wenyi: MDiploma thesis: Der Prostaglandintransporter MRP4 und Ovarialkarzinom (05/2011 – 12/2014). Medical University of Vienna

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology c) PhD, MDSci, MD students: n =13

Isabella Ellinger:

Klameth Lukas: PhD thesis (N094): Expression of pH-regulators NHE1 (sodium-proton exhchanger 1), MCTs (monocarboxylate transporters) and CAIX (carbonic anhydrase IX) in small cell lung cancer (SCLC) and ovarian cancer cell lines and their role in chemoresistance. (07/2013 – in progress). Medical University of Vienna

Liedauer Richard: PhD thesis (N790): Clinical experimental oncology. (09/2014 – in progress) Medical University of Vienna

Elisabeth Straka: PhD thesis (N790): Mercury toxicokinetics in human placenta.(11/2014 – in progress) Medical University of Vienna.

Diana Mechtcheriakova:

Anastasia Meshcheryakova: PhD thesis (N094) Definition of novel breakpoints in the sphingolipid machinery under pathophysiological conditions with particular focus on interconnection with the immune system. (08/2011 – in progress) Medical University of Vienna

Renate Fuchs:

Ganjian Haleh: PhD thesis (N790): Rhinovirus infections of airway epithelial (02/2013 – in progress) Medical University of Vienna

Peter Pietschmann:

Föger-Samwald Ursula: PhD thesis (N790): Gene expression, bone turnover markers, and microarchitecture in metabolic bone diseases (02/2013 – in progress) Medical University of Vienna

Gfrerer Lisa: PhD thesis(N094): Functional analysis of IRF6 and SPECC1l in Zebrafish models of orofacial cleft (12/2012 – 12/2014) Medical University of Vienna

Maldonado-Gonzalez Eduardo: PhD thesis (N790). The role of Serotonin transporter (5-HTT) and insulin degrading enzyme (IDE) Polymorphism in vascular diseases (05/2011 – in progress) Medical University of Vienna.

Raimann Adalbert: PhD thesis (N790): Impact of FGF23 on growth plate chondrocytes. (12/2013 – in progress) Medical University of Vienna

Vekszler György: PhD thesis (N790). Micro architecture of historic bone samples with tuberculosis. (10/2014- in progress) ) Medical University of Vienna

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Wakolbinger Robert: PhD thesis (N790). Bone microarchitecture in patients suffering from hepatic cirrhosis: A high-resolution peripheral quantitative computed tomography study. (09/2014 – in progress). Medical University of Vienna

Theresia Thalhammer:

Riha Juliane, Mag.pharm: PhDPharm Thesis. Metebolismus und Transport neuer Zytostatika in humanen Tumorzelllinien in Gewebe (10/2009 – 11/2014), University of Vienna.

Rogojanu Radu: PhD Thesis (N094). Automatic recognition of tumor areas in colon cancer (03/2009 – in progress), Medical University of Vienna

d) practical training for other diploma thesis:

Isabella Ellinger:

Stefan Grbic: Diploma Thesis: Biochemische und histologische Untersuchungen zur Erforschung der Rolle des Aminosäuretransportsystems L (LAT1/4F2 bei der Aufnahme von Methylquecksilber in die Plazenta. (01-05/2014). HBLVA für Chemische Industrie

Michaela Jungmann: Diploma Thesis: Topographie des FcRn (neonataler Fc-Rezeptor-)-mediierten IgG Transportes in der humanen Plazenta. (09/2014 – 04/2015) HBLVA für Chemische Industrie

Lena Kuhn: Diploma Thesis: Expression und Lokalisation von Melatoninrezeptoren in perivaskulären Adipozyten. Untersuchungen zum Verständnis des Mechanismus der Blutdruckregulation durch Melatonin – Expression und Lokalisation von Melatoninrezeptoren in perivaskulären Adipozyten. (09/2014 – 04/2015) HBLVA für Chemische Industrie

Bernhard Seidelmann: Diploma Thesis: Expression und Lokalisation von Melatoninrezeptoren in perivaskulären Adipozyten. Untersuchungen zum Verständnis des Mechanismus der Blutdruckregulation durch Melatonin – Expression und Lokalisation von Melatoninrezeptoren in perivaskulären Adipozyten. (09/2014 – 04/2015) HBLVA für Chemische Industrie

e) summer practical training:

Talente: Praktika für Schülerinnen und Schüler 2014

Huber Maximilian: Thema: „Melatonin/Blutdruck 3“, HBLVA für Chemische Industrie, Rosensteingasse, 4.8. – 29.8.2014

Kuhn Lena: Thema: „Melatonin/Blutdruck 1“, HBLVA für Chemische Industrie, Rosensteingasse, 4.8. – 29.8.2014

Seidelmann Bernhard: Thema: „Melatonin/Blutdruck 2“, HBLVA für Chemische Industrie, Rosensteingasse, 4.8. – 29.8.2014

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology f) coordination of doctoral programs:

Peter Pietschmann:

Coordinator of the doctoral program “Regeneration of Bone and Joints”

1.2.14. Exams a) Oral examinations: n = 1

b) Diploma and Thesis-Examinations: n = 8

Isabella Ellinger:

Pia Habringer, MD Diploma Examination, 6.5.2015 Astrid Woditschka, MD Diploma Examination, 5.5.2014 Zahra Umar, MD Diploma Examination, 16.5.2014 Angelika Schultze, MD Diploma Examination, 23.6.2014 Yuliya Mytsko, Diploma (Master) Biology Examination, 27.8.2014

Peter Pietschmann:

Veronika Hruschka, PhD Thesis Examination, 11.2.2014 Gerold Zimmer, PhD Thesis Examination, 19.5.2014 Alexander Valentinitsch, PhD Thesis Examination, 29.10.2014

c) Exam supervising: n = 2

Isabella Ellinger:

SSM2: 13.3.2014, 8:00 – 10.00 Uhr SSM 1: 15.10.2014, 16:40-19:30 Uhr

d) Reviewing of Doctoral Thesis: n =1

Theresia Thalhammer, Medical University Vienna

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.2.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2014 Ellinger Isabella 2.27 2.40 802001 BL 4 - Funktionssysteme und biologische Regulation Ellinger Isabella 1.00 1.17 806009 Ärztliche Gesprächsführung B Ellinger Isabella 2.27 0.75 806021 SSM 2 - Methoden der zellulären Pathophysiologie Ellinger Isabella 4.00 0.50 808004 SSM 3-Projektstudie (Wahlpflichtteil) Ellinger Isabella 2.00 0.14 850101 Basic Lectures Ellinger Isabella 1.00 0.20 860015 Stimulating Friday Seminar Ellinger Isabella 1.00 0.33 860021 Creative and critical Journal Club Fuchs Renate 2.27 2.81 802001 BL 4 - Funktionssysteme und biologische Regulation Fuchs Renate 2.27 0.75 806021 SSM 2 - Methoden der zellulären Pathophysiologie Fuchs Renate 1.00 0.20 860015 Stimulating Friday Seminar Fuchs Renate 2.27 0.39 802001 BL 4 - Funktionssysteme und biologische Regulation Graf Jürg 3.00 0.60 840053 Medizinisches Propädeutikum Teil 2 Mechtcheriakova Diana 1.00 0.20 860015 Stimulating Friday Seminar Mechtcheriakova Diana 2.00 0.66 860059 TS: New Developments and comparative aspects in allergology, oncology and immunology Mechtcheriakova Diana 2.00 0.20 860079 JC New Developments and comparative aspects in allergology, oncology and immunology Pietschmann Peter 2.53 0.40 804000 BL 10 - Endokrinologie und Stoffwechsel Pietschmann Peter 2.27 0.75 806021 SSM 2 - Methoden der zellulären Pathophysiologie Pietschmann Peter 2.00 0.28 850101 Basic Lectures Pietschmann Peter 2.00 2.00 850102 Thesis Seminar (TS Bones and Joint Regeneration) Pietschmann Peter 1.00 0.13 850103 Journal Club (JC Bones and Joint Regeneration) Pietschmann Peter 2.00 0.05 860001 JC Endocrinology and Metabolism "SS 2014" (Pflichtfach) Pietschmann Peter 2.00 0.05 860004 TS Endocrinology and Metabolism - SS 2014 (Wahlpflichtfach) PS: "Clinical Endocrinology, Metabolism and Nutrition SS 2014 (Wahpflichtfach, compulsory Pietschmann Peter 2.00 0.05 860005 optional course) Pietschmann Peter 1.00 0.20 860015 Stimulating Friday Seminar Pietschmann Peter 1.00 0.33 860021 Creative and critical Journal Club Pietschmann Peter 2.00 0.25 860220 Basisvorlesung Immunologie Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Pietschmann Peter 2.00 0.70 860302 Anwendungsmöglichkeiten Pietschmann Peter 2.00 0.18 870012 Medical Propedeutics I - Anatomy & Physiology - SS 2014 Pietschmann Peter 2.00 1.00 881005 Pathophysiology for Biotechnologists

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Pietschmann Peter 2.00 0.25 902653 Practical Seminar (Doctoral Program N790 "Bones and Joint Regeneration") Thalhammer Theresia 2.00 0.05 860001 JC Endocrinology and Metabolism "SS 2014" (Pflichtfach) Thalhammer Theresia 2.00 0.05 860004 TS Endocrinology and Metabolism - SS 2014 (Wahlpflichtfach) PS: "Clinical Endocrinology, Metabolism and Nutrition SS 2014 (Wahpflichtfach, compulsory Thalhammer Theresia 2.00 0.05 860005 optional course) Thalhammer Theresia 1.00 0.20 860015 Stimulating Friday Seminar Sum 18.27

WS 2014/15 Ellinger Isabella 1.13 1.07 801001 BL 1 - Gesunde und kranke Menschen Ellinger Isabella 1.07 1.33 801004 BL 2 - Der menschliche Körper Ellinger Isabella 1.73 1.87 801006 BL 3 - Vom Molekül zur Zelle Ellinger Isabella 0.50 0.47 803001 BL 7 - Wissenschaft und Medizin (SSM 1) Ellinger Isabella 2.50 2.50 803074 SSM 1 - Entstehung von AGEs und ihre Rolle bei chronischen Erkrankungen Ellinger Isabella 1.00 0.34 860001 Creative and critical Journal Club I Ellinger Isabella 1.00 0.20 860006 TS: Stimulating Friday Seminar I Fuchs Renate 1.13 3.73 801001 BL 1 - Gesunde und kranke Menschen Fuchs Renate 6.27 1.33 801005 BL 3 - Vom Molekül zur Zelle Fuchs Renate 1.73 4.27 801006 BL 3 - Vom Molekül zur Zelle Fuchs Renate 2.50 2.50 803051 SSM 1 - Mechanismus von Virusinfektionen Fuchs Renate 2.27 0.27 805002 BL 14 - Niere und Homöostase Fuchs Renate 1.00 0.20 860006 TS: Stimulating Friday Seminar I Fuchs Renate 2.00 0.18 562019 BVo: Immunologie Graf Jürg 2.27 0.73 805002 BL 14 - Niere und Homöostase Graf Jürg 3.00 0.66 840052 Medizinisches Propädeutikum Teil 1 Mechtcheriakova Diana 2.00 0.66 648802 Progress Report in Comparative Allergology, Oncology and Immunology Mechtcheriakova Diana 1.00 0.20 860006 TS: Stimulating Friday Seminar I Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Pietschmann Peter 2.00 0.70 653346 Anwendungsmöglichkeiten Pietschmann Peter 5,80 0.40 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Pietschmann Peter 4.00 0.13 807002 BL 21 - Bewegung und Leistung, Schmerz Pietschmann Peter 4.53 0.07 807009 BL 22/23 - Public Health Pietschmann Peter 5.87 1.20 825001 BL Z-1 Kau- und Bewegungsapparat Pietschmann Peter 1.00 0.20 850081 Journal Club (Doctoral Program N790 "Bones and Joint Regeneration")

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Pietschmann Peter 2.00 1.00 850082 Thesis Seminar (Doctoral Program N790 "Bones and Joint Regeneration") Pietschmann Peter 1.00 0.34 860001 Creative and critical Journal Club I Pietschmann Peter 1.00 0.20 860006 TS: Stimulating Friday Seminar I Pietschmann Peter 2.00 0.06 860024 JC Endocrinology and Metabolism WS 2014/15 Pietschmann Peter 2.00 0.06 860025 TS Endocrinology and Metabolism WS 2014/15 Thalhammer Theresia 2.00 0.06 860024 JC Endocrinology and Metabolism WS 2014/15 Thalhammer Theresia 2.00 0.06 860025 TS Endocrinology and Metabolism WS 2014/15 Thalhammer Theresia 2.00 0.06 860026 Basic Seminar "Endocrinology and Metabolism I" (Wahlpflichtfach) Sum 27.05 Total sum SS+WS 45.32

Lectures at other Universities:

Isabella Ellinger:

 Veterinary University of Vienna (Interdisciplinary Master Comparative Medicine): total 0,5 SWSt

o 20.3.2014: Pathology of Reproduction and Animal Models, 3,5 h o 2.10.2014: Cell Biology, 2h o 4.12.2014: Human Reproduction, 2h

 Karl Landsteiner Privat Universität: total 0,07 SWSt

o 23.10.2014: Primary Immunodeficiency Diseases, 1 h

 Coordinator of the Modul 8 at Karl Landsteiner Privat Universität (10/2014)

Performance Report 2014 – Division 3 Immunpathology

1.3 Division for Immunpathology Head: Rudolf Valenta, MD, Professor

1. Publications7 pro-rata IF Number Top/Std/Subst Flicker Sabine 11.136 5 4 Top/1 Std Focke-Tejkl Margarete 29.119 9 9 Top Linhart Birgit 4.324 2 2 Top/ Valenta Rudolf 124.877 30 22 Top/8 Std Vrtala Susanne 17.781 8 8 Top/ Division-Sum 138.272 24 Top/7 Std. Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Flicker Sabine 2 Focke-Tejkl Margarete 2 Linhart Birgit 2 Valenta Rudolf 2 6 Vrtala Susanne 4 Sum 2 16

3. Teaching SS* WS* total W+S Flicker Sabine 0.0 2.24 2.24 Focke-Tejkl Margarete 2.11 4.31 6.42 Linhart Birgit 0.0 1.77 1.77 Valenta Rudolf 19.08 18.82 37.90 Vrtala Susanne 1.11 5.8 6.91 Sum 22.30 21.94 55.24

7 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 65

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.3.1. Publications a) Peer-reviewed original articles: n = 31 Nr. Article IF Class pro-rata IF 1. Baar, A., S. Pahr, C. Constantin, S. Giavi, A. Manoussaki, N. 11.248 TOP 11.248 G. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, and R. Valenta. 2014. Specific IgE reactivity to Tri a 36 in children with wheat food allergy. J. Allergy Clin. Immunol. 133: 585- 587, doi: 10.1016/j.jaci.2013. 2. Baar, A., S. Pahr, C. Constantin, S. Giavi, N.G. 5.995 TOP 5.995 Papadopoulos, A.S. Pelkonen, M. Makela, S. Scheiblhofer, J. Thalhamer, M. Weber, C. Ebner, A. Mari, S. Vrtala, and R. Valenta. 2014. The high molecular weight glutenin subunit Bx7 allergen from wheat contains repetitive IgE epiTopes. Allergy 69: 1316-1323,. doi: 10.1111/all.12464. 3. Banerjee, S., M. Weber, K. Blatt, I. Swoboda, M. Focke- 5.362 TOP 5.362 Tejkl, P. Valent, R. Valenta, and S. Vrtala. 2014. Conversion of Der p 23, a New Major House Dust Mite Allergen, into a Hypoallergenic Vaccine. J. Immunol. 192: 4867-4875, doi: 10.4049/jimmunol.1400064.. 4. Bonura, A., A. Trapani, L. Gulino, V. Longo, R. Valenta, R. 3.003 Std. 0.600 Asero, and P. Colombo. 2014. Cloning, expression in E. coli and immunological characterization of Par j 3.0201, a Parietaria pollen profilin variant. Mol. Immunol. 57: 220-225, doi: 10.1016/j.molimm.2013.09.004.. 5. Bousquet, J., A. Addis, I. Adcock, I. Agache, A. Agusti, A. 7.125 TOP 1.425 Alonso, I. Annesi-Maesano, J.M. Anto, C. Bachert, C.E. Baena-Cagnani, C. Bai, A. Baigenzhin, C. Barbara, P.J. Barnes, E.D. Bateman, L. Beck, A. Bedbrook, E.H. Bel, O. Benezet, K.S. Bennoor, M. Benson, M. Bernabeu-Wittel, M. Bewick, C. Bindslev-Jensen, H. Blain, F. Blasi, M. Bonini, S. Bonini, L.P. Boulet, A. Bourdin, R. Bourret, P.J. Bousquet, C.E. Brightling, A. Briggs, J. Brozek, R. Buhl, A. Bush, D. Caimmi, M. Calderon, P. Calverley, P.A. Camargos, T. Camuzat, G.W. Canonica, K.H. Carlsen, T.B. Casale, M. Cazzola, A.M. Cepeda Sarabia, A. Cesario, Y.Z. Chen, E. Chkhartishvili, N.H. Chavannes, R. Chiron, A. Chuchalin, K.F. Chung, L. Cox, G. Crooks, M.G. Crooks, A.A. Cruz, A. Custovic, R. Dahl, S.E. Dahlen, F. De Blay, T. Dedeu, D. Deleanu, P. Demoly, P. Devillier, A. Didier, A.T. Dinh-Xuan, R. Djukanovic, D. Dokic, H. Douagui, R. Dubakiene, S. Eglin, F. Elliot, R. Emuzyte, L. Fabbri, A. Fink Wagner, M. Fletcher, W.J. Fokkens, J. Fonseca, A. Franco, P. Frith, A. Furber, M. Gaga, J. Garcés, J. Garcia-Aymerich, A. Gamkrelidze, S. Gonzales-Diaz, F. Gouzi, M.A. Guzmán, T. Haahtela, D. Harrison, M. Hayot, L.G. Heaney, J. Heinrich, P.W. Hellings, J. Hooper, M. Humbert, M. Hyland, G. Iaccarino, D. Jakovenko, J.R. Jardim, C. Jeandel, C. Jenkins, S.L. Johnston, O. Jonquet, G. Joos, K.S. Jung, O. Kalayci, S. Karunanithi, T. Keil, N. Khaltaev, V. Kolek, M.L. Kowalski, I. Kull, P. Kuna, V. Kvedariene, L.T. Le, K.C. Lodrup Carlsen, R. Louis, W. MacNee, A. Mair, I. Majer, P. Manning, E. de 66

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Manuel Keenoy, M.R. Masjedi, E. Melen, E. Melo-Gomes, A. Menzies-Gow, G. Mercier, J. Mercier, J.P. Michel, N. Miculinic, F. Mihaltan, B. Milenkovic, M. Molimard, I. Momas, A. Montilla-Santana, M. Morais-Almeida, M. Morgan, M. N'Diaye, S. Nafti, K. Nekam, A. Neou, L. Nicod, R. O'Hehir, K. Ohta, P. Paggiaro, S. Palkonen, S. Palmer, N.G. Papadopoulos, A. Papi, G. Passalacqua, I. Pavord, B. Pigearias, D. Plavec, D.S. Postma, D. Price, K.F. Rabe, F. Radier Pontal, J. Redon, S. Rennard, J. Roberts, J.M. Robine, J. Roca, N. Roche, F. Rodenas, A. Roggeri, C. Rolland, J. Rosado-Pinto, D. Ryan, B. Samolinski, M. Sanchez-Borges, H.J. Schünemann, A. Sheikh, M. Shields, N. Siafakas, Y. Sibille, T. Similowski, I. Small, O. Sola-Morales, T. Sooronbaev, R. Stelmach, P.J. Sterk, T. Stiris, P. Sud, V. Tellier, T. To, A. Todo-Bom, M. Triggiani, R. Valenta, A.L. Valero, A. Valiulis, E. Valovirta, E. Van Ganse, O. Vandenplas, T. Vasankari, J. Vestbo, G. Vezzani, G. Viegi, L. Visier, C. Vogelmeier, T. Vontetsianos, R. Wagstaff, U. Wahn, B. Wallaert, B. Whalley, M. Wickman, D.M. Williams, N. Wilson, B.P. Yawn, P.K. Yiallouros, A. Yorgancioglu, O.M. Yusuf, H.J. Zar, N. Zhong, M. Zidarn, and T. Zuberbier. 2014. Integrated care pathways for airway diseases (AIRWAYS- ICPs). Eur. Respir J. 44: 304-323, doi: 10.1183/09031936.00014614. 6. Bousquet, J., J.E. Gern, F.D. Martinez, J.M. Anto, C.C. 11.248 TOP 2.249 Johnson, P.G. Holt, R.F. Lemanske Jr, P.N. Le Souëf, R.S. Tepper, E.R. von Mutius, S.H. Arshad, L.B. Bacharier, A. Becker, K. Belanger, A. Bergström, D.I. Bernstein, M.D. Cabana, K.N. Carroll, M. Castro, P.J. Cooper, M.W. Gillman, D.R. Gold, J. Henderson, J. Heinrich, S.J. Hong, D.J. Jackson, T. Keil, A.L. Kozyrskyj, K.L. Carlsen, R.L. Miller, I. Momas, W.J. Morgan, P. Noel, D.R. Ownby, M. Pinart, P.H. Ryan, J.M. Schwaninger, M.R. Sears, A. Simpson, H.A. Smit, D.A. Stern, P. Subbarao, R. Valenta, X. Wang, S.T. Weiss, R. Wood, A.L. Wright, R.J. Wright, A. Togias, P.J. Gergen. 2014. Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop. J. Allergy Clin. Immunol. 133: 1535-1546, . doi: 10.1016/j.jaci.2014.01.018 7. Breiteneder, H., and R. Valenta. 2014. Recombinant allergen 3.221 Std. 3.221 methods. Methods 66: 1-2, doi: 10.1016/j.ymeth.2014.02.026 8. Cabauatan, C.R., C. Lupinek, S. Scheiblhofer, R. Weiss, M. 11.248 TOP 11.248 Focke-Tejkl, P.L. Bhalla, M.B. Singh, P.A. Knight, M. van Hage, J.D. Ramos, and R. Valenta. 2014. Allergen microarray detects high prevalence of asymptomatic IgE sensitizations to tropical pollen-derived carbohydrates. .J Allergy Clin. Immunol. 133: 910-914.e5, doi: 10.1016/j.jaci.. 9. Canonica G.W, R Valenta, and R. Pawankar.2014. In 2.433 Std. 0.486 memoriam – a tribute to Carlos e. Baena-Cagnani. 2014. Int. Arch. Allergy Immunol. 165: 270, DOI: 10.1159/000375122 10. Curin, M., I. Swoboda, E. Wollmann, C. Lupinek, S. 11.248 TOP 11.248 Spitzauer, M. van Hage, and R. Valenta. 2014. Microarrayed dog, cat, and horse allergens show weak correlation between allergen-specific IgE and IgG responses. J Allergy Clin 67

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Immunol. 133: 918-921.e6 doi: 10.1016/j.jaci.2013, . 11. Curin, M., M. Weber, T. Thalhamer, I. Swoboda, M. Focke, 4.324 TOP 4.324 K. Blatt, P. Valent, K. Marth, T. Garmatiuk, H. Grönlund, J. Thalhamer, S. Spitzauer, and R. Valenta. 2014. Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction. Clin. Exp. Allergy. 44: 882-894, doi: 10.1111/cea.12294. 12. Deifl S, Zwicker C, Vejvar E, Kitzmüller C, Gadermaier G, 3.534 TOP 0.707 Nagl B, Vrtala S, Briza P, Zlabinger GJ, Jahn-Schmid B, Ferreira F, Bohle B. Glutathione-S-transferase: a minor allergen in birch pollen due to limited release from hydrated pollen. PLoS One. 2014 9:e109075, . doi: 10.1371/journal.pone.0109075. 13. Devanaboyina, S. C., C. Cornelius, C. Lupinek, K. Fauland, 5.995 TOP 1.199 F. Dall´Antonia, A. Nandy, S. Hagen, S. Flicker, R. Valenta, and W. Keller. 2014. High resolution crystal structure and IgE cross reactivity of the major grass pollen allergen Phl p 3. Allergy 69: 1617-1628, doi: 10.1111/all.12511. 14. Focke-Tejkl, M., M. Weber, K. Niespodziana, A. Neubauer,1 11.248 TOP 11.248 H. Huber, R. Henning, G. Stegfellner, B. Maderegger, M. Hauer, F. Stolz, V. Niederberger, K. Marth, J. Eckl-Dorna, R. Weiss, J. Thalhamer, K. Blatt, P. Valent, and R. Valenta. 2014. Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy. J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2014.09.012. 15. Focke-Tejkl, M., R. Campana, R. Reininger, C. Lupinek, K. 11.248 TOP 11.248 Blatt, P. Valent, T. Pavkov-Keller, W. Keller, and R. Valenta. 2014. Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5. J. Allergy Clin. Immunol. 133: 836-845.e11, doi: 10.1016/j.jaci.2013.08.038. 16. Gadermaier, E., S. Flicker, K. Blatt, P. Valent, and R. 5.995 TOP 5.995 Valenta. 2014. Possible therapeutic potential of a recombinant group 2 grass pollen allergen-specific antibody fragment. Allergy 69: 261-264,. doi: 10.1111/all.12315. 17. Hochwallner, H., J. Alm, C. Lupinek, C. Johansson, A. Mie, 11.248 TOP 11.248 A. Scheynius, and R. Valenta. 2014. Transmission of allergen – specific IgG and IgE from maternal blood into breast milk visualized with microarray technology. J. Allergy. Clin. Immunol. 134: 1213-1215, . doi: 10.1016/j.jaci.2014.08.041... 18. Hochwallner, H., U. Schulmeister, I. Swoboda, S. Spitzauer,1 3.221 Std. 3.221 . and R. Valenta. 2014. Cow's milk allergy: From allergens to new forms of diagnosis, therapy and prevention. Methods 66: 22-33, doi: 10.1016/j.ymeth.2013.08.005.. 19. Hradetzky, S., L. M. Roesner, H. Balaji, A. Heratizadeh, I. 6.372 TOP 1.274 Mittermann, R. Valenta, and T. Werfel. 2014. Cytokine effects induced by the human autoallergen α-NAC. J. Invest. Dermatol. 134: 1570-1578, doi: 10.1038/jid.2014.25. 20. Levin, M., S. Rotthus, S. Wendel, N. Najafi, E. Källström, M. 4.324 TOP 0.865 Focke-Tejkl, R. Valenta, S. Flicker, and M. Ohlin. 2014. Multiple independent IgE epiTopes on the highly allergenic 68

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

grass pollen allergen Phl p 5. Clin. Exp. Allergy. 44: 1409- 1419, doi: 10.1111/cea.12423. 21. Linhart, B., M. Narayanan, M. Focke-Tejkl, F. Wrba, S. 4.324 TOP 4.324 Vrtala, and R. Valenta. 2014. Prophylactic and therapeutic vaccination with carrier-bound Bet v 1 peptides lacking allergen-specific T cell epiTopes reduces Bet v 1-specific T cell responses via blocking antibodies in a murine model for birch pollen allergy. Clin. Exp. Allergy. 44: 278-287, doi: 10.1111/cea.12216. . . 22. Lupinek, C., E. Wollmann, A. Baar, S. Banerjee, H. 3.221 TOP 3.221 Breiteneder, B.M. Broecker, M. Bublin, M. Curin, S. Flicker, T. Garmatiuk, H. Hochwallner, I. Mittermann, S. Pahr, Y. Resch, K.H. Roux, B. Srinivasan, S. Stentzel, S. Vrtala, LN. Willison, M. Wickman, K. Lødrup-Carlsen, J.M. Antó, J. Bousquet, C. Bachert, D. Ebner, T. Schlederer, C. Harwanegg, and R. Valenta. 2014. Advances in allergen- microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip. Methods 66: 106-119, doi: 10.1016/j.ymeth.2013.10.008.. 23. Marth, K., E. Wollmann, D. Gallerano, P. Ndlovu, I. Makupe, 3.534 TOP 3.534 R. Valenta, and E. Sibanda. 2014. Persistence of IgE- Associated Allergy and Allergen-Specific IgE despite CD4+ T Cell Loss in AIDS. PLoS One 9: e97893, doi: 10.1371/journal.pone.0097893. 24. Niespodziana, K., Cabauatan, C.R., Jackson, D.J., 2.108 Std. 2.108 Gallerano, D., Trujillo-Torralbo, B., del Rosario, A., Mallia, P., Valenta, R., and Johnston, S.L. Rhinovirus-induced VP1- specific Antibodies are Group-specific and Associated With Severity of Respiratory Symptoms. EBioMedicine 2014; doi:10.1016/j.ebiom.2014.11.012. 25. Pahr, S., R. Selb, M. Weber, M. Focke-Tejkl, G. Hofer, A.2 3.534 TOP 3.534 . Dordic, W. Keller, N. G. Papadopoulus, S. Giavi, M. Mäkelä, A. Pelkonen, V. Niederberger, S. Vrtala, and R. Valenta. 2014. Biochemical, biophysical and IgE-epiTope characterization of the wheat food allergen. Tri a 37. PLoS One 9: e111483, doi: 10.1371/journal.pone.0111483 26. Pfanzagl, B., D. Andergassen, J. Edlmayr, K. Niespodziana , 2.282 Std. 0.456 R. Valenta, and D. Blaas. 2014. Entry of human rhinovirus 89 via ICAM-1 into HeLa epithelial cells is inhibited by actin skeleton disruption and by bafilomycin. Arch. Virol. 159: 125- 140, doi: 10.1007/s00705-013-1797-1. . 27. Raith M, Klug C, Sesztak-Greinecker G, Balic N, Focke M, 2.746 TOP 2.746 Linhart B, Hemmer W, Swoboda I. Unusual sensitization to parvalbumins from certain fish species. Ann Allergy Asthma Immunol. 2014;113:571-572. 28. Saenger, T., A. Braukmann, S. Vordenbäumen, I. Altendorfer , 2.829 Std. 2.829 E. Bleck, H. Hochwallner, R. Valenta, M. Schneider, and J. Jose. 2014. Development of a surface display ELISA to detect anti-IgG antibodies against bovine α3.123S1-casein in human sera. J. Pharm. Biomed. Anal. 96: 144-150, doi: 10.1016/j.jpba.2014.03.032. .

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

29. Szépfalusi, Z., C. Bannert, L. Lonceray, E. Mayer, M. Hassler, 3.859 TOP 0.772 E. Wissmann, E. Dehlink, S. Gruber, A. Graf, C. Lupinek, R. Valenta, T. Eiwegger, and R. Urbanek. 2014. Preventive sublingual immunotherapy in preschool children: first evidence for safety and pro- tolerogenic effects. Pediatr. Allergy. Immunol. 25: 788-795. doi: 10.1111/pai.12310. 30. Vrtala S, Huber H, Wayne R.T. Recombinant house dust mite3 3.221 TOP 3.221 . allergens. Methods. 2014 66:67-74, doi: 0.1016/j.ymeth.2013.07.034 31. Westman, M., C. Lupinek, J. Bousquet, N. Andersson, S. 11.248 TOP 2.250 Pahr, A. Baar, A. Bergström, M. Holmström, P. Stjärne, K. C. L. Carlsen, K. H. Carlsen, J. M. Antó, R. Valenta, M. v. Haage, and M. Wickman. 2014. Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence. J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2014.10.042. sum 182.546 133.406

b) Invited Articles & Reviews with IF: n = 2

Nr. Article IF Class pro-rata IF 1. Gadermaier, E., M. Levin, S. Flicker, M. Ohlin., The Human 2.433 Std. 2.433 IgE Repertoire, Int. Arch Allergy Immunol 163:77-91 2. Hochwallner H. Ready for a milk shake? Int Arch Allergy 2.433 Std. 2.433 Immunol. 2014;164(3):167-8. Editorial sum 4.866 4.866

c) Invited Articles & Reviews without IF: n = 1 1. Marth K, Focke-Tejkl M, Lupinek C, Valenta R, Niederberger V. Allergen Peptides, Recombinant Allergens and Hypoallergens for Allergen-Specific Immunotherapy. Curr Treat Options Allergy. 2014; 1:91-106. eCollection 2014.

d) Book contributions: n = 0

e) Abstracts, printed in periodicals: n = 0

f) Abstracts, in congress proceedings or abstract books: n = 18

1. Campana R., K. Moritz, A. Neubauer, H. Huber, R. Henning, K. Blatt, G. Hoermann, T. Brodie, A. Kaider, P. Valent, F.Salusto, S. Wöhrl, R.Valenta. Epicutaneous application of recombinant Bet v 1 and Bet v 1 derivatives induces allergen-specific IgG and T cell responses. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Austria, 2014. 2. Chen K.W., P. Zieglmayer, R. Zieglmayer, P. Lemmel, F. Horak, R. Valenta, S. Vrtala: Failure of specific immunotherapy (SIT) with house dust mite (HDM) allergen extracts due to lack of HDM allergens capable of inducing specific IgG responses in the therapeutic extracts. ÖGAI Annual Meeting, Salzburg, Austria, November 6-8, 2014. 70

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

3. Curin M., T. Garmatiuk, Y. Resch, KW. Chen, K. Prettler, W. Keller, C. Ebner, W. Hemmer, S.Vrtala, M.Focke-Tejkl, R. Valenta. IgE-reactive epiTopes of the house dust mite allergen Der p 5. Congress of the European Academy of Allergy and Clinical Immunology (EAACI), 2014, Copenhagen, Denmark. 4. Gadermaier E., L. K. James, M. H. Shamji, K. Blatt, K. Fauland, P. Zieglmayer, T. Garmatiuk, M. Focke-Tejkl, R. Beavil, W. Keller, P. Valent, S. R. Durham, H. J. Gould, S. Flicker, R. Valenta. A Phl p 7-specific IgG4 antibody inhibits allergic patients IgE cross-reactivity to allergens from the EF-hand family: Importance of affinity and degree of cross-reactivity. Retreat of the Center for Pathophysiology; Infectiology and Immunology, Vienna, Austria, September 16, 2014. 5. Garib V., E.Wollmann, G.Gjambekova, R.Valenta. Differences in molecular sensitization profiles towards animal allergens revealed by allergen micro-array in two generation of patients with respiratory allergy ÖGAI Jahrestagung, Salzburg. Austria, 2014. 6. Garib V., E.Wollmann, G.Gjambekova, R.Valenta. In-print of the environment on the molecular sensitization profile towards pollen allergens revealed by allergen microarray. ÖGAI Jahrestagung, Salzburg. Austria, 2014. 7. Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, Reininger R, Civaj V, Campana R, Thalhamer J, Scheiblhofer S, Balic N, Horak F, Ollert M, Papadopoulos NG, Quirce S, Szepfalusi Z, Herz U,. van Tol EAF, Spitzauer S, Valenta R. Allergenic activity and ability to induce T cell and cytokine responses of different infant milk formulas. WAO International Scientific Conference, 6.-9.December 2014. Rio de Janeiro, Brazil. 8. Huang H-J., M. Curin, S. Banerjee, K-W. Chen, T. Garmatiuk, Y. Resch, R. Campana, M. Focke-Tejkl, R. Valenta, S. Vrtala Towards a non-allergenic peptide mix containing the T cell epitopes of relevant house dust mite allergens. ÖGAI Annual Meeting, Salzburg, Vienna, Austria, November 6-8, 2014. 9. Madritsch C, E. Gadermaier, C. Lupinek, R. Valenta, S. Flicker. High density IgE recognition of the major grass pollen allergen, Phl p 1, revealed with single chain IgE antibody fragments obtained by combinatorial cloning.Austrian Society for Allergology and Immunology, Jahrestagung, Salzburg, Austria, November 6-8, 2014. 10. Madritsch C., E. Gadermaier, C. Lupinek, R. Valenta, S. Flicker. High density IgE recognition of the major grass pollen allergen, Phl p 1, revealed with single chain IgE antibody fragments obtained by combinatorial cloning. 10th YSA PhD-Symposium, Austria, June 11+12, 2014. 11. Marth K., E. Wollmann, D. Gallerano, P. Ndlovu, I Makupe, R. Valenta, E. Sibanda. Persistence of IgE-associated allergy and allergen-specific IgE despite CD4+ T cell loss in AIDS, Annual meeting of the Austrian Society of Pneumology, Salzburg, Austria, 2014. 12. Mittermann I., Gustav Wikberg, Catharina Johansson, Christian Lupinek, Lena Lundeberg, Reto Crameri, Rudolf Valenta, Annika Scheynius. Molecular IgE sensitization profiles differ between patients with severe and moderate aTopic dermatitis. Inflammatory Skin Disease Summit 2014, November 19-21, 2014, Vienna, Austria. 13. Pahr S., S, R. Selb, C. Constantin, M. Weber, M. Focke-Tejkl, G. Hofer, A. Dordić, W. Keller, NG Papadopoulos, S. Giavi, M. Mäkelä, A. Pelkonen, I. Mittermann, V. Niederberger, S. Vrtala, R. Valenta. Biochemical, structural, immunological characterization and IgE epiTope mapping of an important wheat food allergen, Tri a 37. Falk Symposium 193 (Celiac Disease and Other Small Bowel Disorders), Amsterdam, The Netherlands, September 5 - 6, 2014.

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

14. S. Pahr S, R. Selb, C. Constantin, M. Weber, M. Focke-Tejkl, G. Hofer, A. Dordić, W. Keller, NG Papadopoulos, S. Giavi, M. Mäkelä, A. Pelkonen, V. Niederberger, S. Vrtala, R. Valenta. Characterization and IgE epiTope mapping of Tri a 37, a serological marker for severe wheat food allergy. Annual Meeting of the ÖGAI 2014, Salzburg, Austria, November 6-8, 2014. 15. Resch Y., M. Šilar, P. Kopac, M. Zidarn, KW. Chen, W. Thomas, P. Korosec, M. Kosnik, R. Valenta, S. Vrtala: Beside Der p 1 and Der p 2, also other house dust mite allergens have high allergenic activity. Annual meeting of the ÖGAI, Salzburg, Austria, November 6-8, 2014. 16. Resch Y., S. Michel, M. Kabesch, R. Valenta, S. Vrtala: Analysis of the IgE- and IgG- reactivity profiles of asthmatic and non-asthmatic HDM-allergic patients using the ISAC microarray system. Retreat of the Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, September 16, 2014. 17. Wollmann E., C. Hamsten, E. Sibanda, M. Ochome, M Focke-Tejkl, A Asarnoj, A. Önell, G. Lilja, D. Gallerano, C. Lupinek, T. Thalhamer, R. Weiss, J. Thalhamer, M. Wickman, R. Valenta, M. van Hage. Natural clinical tolerance to peanut in African patients is caused by poor allergenic activity of peanut IgE. DK- IAI, Cell death Inflammation and Immunity DK Joint retreat, Obergurgl, Austria 30.11.-3.12.2014. 18. Wollmann E., C. Hamsten, E. Sibanda, M. Ochome, M Focke-Tejkl, A Asarnoj, A. Önell, G. Lilja, D. Gallerano, C. Lupinek, T. Thalhamer, R. Weiss, J. Thalhamer, M. Wickman, R. Valenta, M. van Hage. Natural clinical tolerance to peanut in African patients is caused by poor allergenic activity of peanut IgE. ÖGAI Annual Meeting, Salzburg, Austria 6.-8.11.2014.

g) Teaching Scripts and Books: n = 1

1. Sabine Flicker, Birgit Linhart, Irene Mittermann Überarbeitung von Lernunterlagen Block 8, Kapitel 3: Allergie, Autoimmunität, Toleranz (Prof. Valenta)

h) Articles in Medical Journals: n = 0

i) Public activity: n = 22

1. Auszeichnungen für ImmunologInnen der MedUni Wien, 3. Dez. 2014 Jahrestagung der ÖGAI, Salzburg, 2014: http://www.meduniwien.ac.at/homepage/news-und- topstories/?Fsize=0&tx_ttnews%5Btt_news%5D=5320&cHash=b756593051cc11c5216 86e2b8df67f29. 2. Lupinek Christian: „Theodor-Billroth-Preis 2014 für Christian Lupinek“, 1. Dez. 2014 (EU-Projekt MeDALL, Leitung: Prof. R. Valenta): http://www.meduniwien.ac.at/hp/cepii/news/singleview/?tx_ttnews%5Btt_news%5D=28 61&cHash=7b2a83a385b472152125d646d2e27eb3. 3. Lupinek Christian: Doktor in Wien 01-2015, Service Chronik, „Ärztekammer prämiert wissenschaftliche Arbeiten“, S. 32. 4. Marth Katharina: Verleihung des Forschungsförderungspreises der Erste Bank der Österreichischen Sparkassen AG-2013 durch die Ärztekammer. Beitrag auf der Startseite der Homepage der MedUniWien im Jänner 2014, die Preisträgerarbeit entstand im SFB F46, Leitung Prof. Rudolf Valenta. (http://www.meduniwien.ac.at/hp/ipa/news/singleview/?tx_ttnews[tt_news]=2338&cHas h=358bf68f90c7a825068f44dd4f2b7b83). 72

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

5. Pahr Sandra: Rudolf Valenta, MedUnique 1-2014, Forschungsfeld Allergien, „Im Fokus: Beißt es?“, S.6-S.10. 6. Valenta Rudolf: „HEUTE“, 9.12.2014, Schnupfen Viren können Asthma-Anfälle auslösen. 7. Valenta Rudolf: „plietsch. Auf der Suche nach der Schnupfenimpfung“, „Den Erkältungsviren auf der Spur“, - 10.11.2014, 21:00Uhr, NDR Fernsehen: http://www.ndr.de/ratgeber/gesundheit/Den-Erkaeltungsviren-auf-der- Spur,plietsch2462.html 8. Valenta Rudolf: „Schnupfen-bedingte Asthma-Anfälle sind durch neuen Test vorhersehbar“, 1. Dez. 2014, (EU-Projekt „Predicta“, Leitung: Prof. R. Valenta): http://www.meduniwien.ac.at/homepage/news-und- topstories/?Fsize=0&tx_ttnews%5Btt_news%5D=5318&cHash=61836b5755f74a14f02f 4aadc5621143. 9. Valenta Rudolf: Auszeichnung bei der 10-Jahres-Jubiläumsfeier der MedUni Wien, 3.10.2014: http://www.meduniwien.ac.at/hp/cepii/news/singleview/?tx_ttnews%5Btt_news%5D=28 32&cHash=869385c49ce7e7c04b65bccfe1daf408. 10. Valenta Rudolf: Der Spiegel Nr. 16/14.4.14, Schutz durch Schmutz. 11. Valenta Rudolf: France 5 public channel, Le monde en face, "Allergies planétaire : à qui la faute ?" , 52 min. documentary, 20.Mai 2014 um 21.40Uhr. 12. Valenta Rudolf: Interview in „Terra Mater“, Feb. 2014- Artikel 13. Valenta Rudolf: Kurier, „Heuschnupfen. Impfstoff aus Wien bringt Hoffnung für Allergiker“, S. 1, 17. März 2014. 14. Valenta Rudolf: Kurier. Lebensart, „Revolution der Allergietherapie, Gräserpollen. S.19, 17. März 2014. 15. Valenta Rudolf: Le Monde, supplément Science et médecine, Médecine: “Allergies: la fin des interdits?” von Sandrine Cabut, 23. April 2014. 16. Valenta Rudolf: MUW News und Topstories: 12.1.2014, Schnupfen-bedingte Astma- Anfälle sind durch neune Test vorhersehbar. 17. Valenta Rudolf: Ö1, Neuer Impfstoff gegen Pollenallergie“, Interview vom 17.3.2014. Valenta Rudolf: Kurier Gesundheitstalk Allergien, Van-Swieten-Saal der MedUni Wien, 19.3.2014. 18. Valenta Rudolf: Ö3 Journal, Neuer Impfstoff gegen Pollenallergie“, Interview vom 17.3.2014. 19. Valenta Rudolf: ORF Nachrichten Landesstudios, Neuer Impfstoff gegen Pollenallergie“, Interview vom 17.3.2014. 20. Valenta Rudolf: ORF ON Sience: News: Medizin und Gesundheit, „Neuer Impfstoff gegen Pollenallergie“, Interview vom 17.3.2014, http://sciencev1.orf.at/science/news/10202. 21. Valenta Rudolf: plietsch. Die wichtigsten Fakten über Erkältung, 10.11.2014, 21Uhr, 12.11.2014, 6:35, 15.11.2014, 14Uhr: http://www.ndr.de/fernsehen/sendungen/plietsch/Die-wichtigsten-Fakten-ueber- Erkaeltung,sendung302416.html. 22. Valenta Rudolf: Spiegel TV Wissen, „Das verschnupfte Volk: Neue Medikamente gegen die Allergienplage“ - Film zum Thema Allergien, 13. April 2014 : http://spon.de/vfM4S.

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.3.2 Research Awards: n = 8 1. Hochwallner Heidrun: ÖGAI Travelgrant for WAO International Scientific Conference 2014 2. Lupinek Christian: Theodor Billroth-Preis 2014 der Ärztekammer für Wien 3. Marth Katharina: Poster prize of the Austrian Society of Pneumology (ÖGP), Annual meeting of the Austrian Society of Pneumology, Salzburg, Austria, 2014 4. Pahr Sandra: Poster Price Falk Symposium 193 (Celiac Disease and Other Small Bowel Disorders), Amsterdam, The Netherlands 5. Pahr Sandra: Travel grant provided by Falk Foundation for the Falk Symposium 193. 6. Dzoro Sheron: full funding of the EFIS-EJI Advanced course, Ceppellini Advanced School of Immunology. 7. Gallerano Daniela: EFIS fellowship, Cappellini School Organising Committee 8. Valenta Rudolf: Ehrung für besondere Leistungen auf dem Gebiet der medizinischen Forschung, MedUni Wien

1.3.3. Invited lectures: n = 46 1. Garib Viktoriya: WAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnostics. Association of Kazakh Allergologists and Immunologists. XIV INTERNATIONAL SCIENTIFIC CONFERENCE «ASTHMA AND ALLERGY», April 24- 25, 2014, Almaty, Kazakhstan. 2. Garib Viktoriya: Advantages of molecular allergy diagnosis. Master-class. Association of Kazakh Allergologists and Immunologists. Dec. 5, 2014, Astana, Kazakhstan. 3. Garib Viktoriya: Advantages of molecular allergy diagnosis. Webinar. Association of Kazakh Allergologists and Immunologists.Nov.28, 2014, Almaty, Kazakhstan. 4. Garib Viktoriya: Allergy in Uzbekistan. U.E.M.S. Meeting Section and Board for Allergology and Clinical Immunology , November, 15, 2014, Vienna, Austria. 5. Garib Viktoriya: Contemporary view to Molecular Allergy Diagnosis. Association of Ukrainian Allergologists and Immunologists. May, 23, 2014, Truskavets,, Ukraine. 6. Garib Viktoriya: Innovative technology in allergy diagnostic: Molecular allergology. Almaty State Medical University. “Kazakhstan-2015 Strategy: Building a world-class university. Dec. 4, 2014, Almaty, Kazakhstan. 7. Garib Viktoriya: Molecular diagnostic of HMD allergy. Ukranian school of Molecular allergology. September, 21, 2014, Kiev, Ukraine. 8. Garib Viktoriya: WAO position papers in molecular allergy diagnostic. International Forum “Clinical Immunology and Allergology – Interdisciplinary Problems, May 14-17, 2014, Kazan, Russia. 9. Linhart Birgit: A recombinant mutant of the major fish allergen parvalbumin shows reduced activity in skin tested fish allergic children and reduces allergic symptoms in a mouse model by blocking antibodies. Symposium of the Collegium Internationale Allergologicum (CIA), September 15, 2014, Petersberg, Germany. 10. Linhart Birgit: Allergies-Analyse industry developments and the future of allergy therapeutics, Passive Immunization with Allergen-Specific IgG Antibodies for the Treatment and Prevention of Allergy, July 9-10, 2014, London, UK. 11. Linhart Birgit: Rekombinante Allergene, 6. Wiener Komponentenschule, August 29. – 30., 2014, Vienna, Austria. 12. Linhart Birgit: Workshop FOOD & ALLERGIES, Recombinant allergens for allergen- specific immunotherapy, April 7-8, 2014, Paris, France. 74

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

13. Lupinek Christian: Characterisation of the MeDALL-chip. 4th annual MeDALL-meeting, January 23-24, Paris, France. 14. Lupinek Christian: IgE-Apherese als universelle Allergietherapie. 45. ÖGIM Jahrestagung, September 26, 2014, Salzburg, Austria. 15. Lupinek Christian: Neue Wege in der Allergiediagnostik, Testmethoden im Überblick. Fortbildung im KH der Barmherzigen Schwestern, November 20, 2014, Linz, Austria. 16. Lupinek Christian: The impact of molecular allergy diagnosis on the management of allergic disease. 10th Panhellenic Allergy & Clinical Immunology Congress, October 16- 19, 2014, Athen, Greece. 17. Lupinek Christian: Vorteile der Komponentendiagnostik, 6. Wiener Komponentenschule, August 29. – 30., 2014, Vienna, Austria. 18. Marth Katharina: Allergenkomponenten für die Indikationsstellung und Verlaufsdiagnose der SIT, 6. Wiener Komponentenschule, August 29. – 30., 2014, Vienna, Austria. 19. Niespodziana Katarzyna: 64th Lindau Nobel Laureate Meeting, June 29 - July 4, 2014; “Science Breakfast: Predicting Phenotypes from Genotypes - a Brave New World”, Lindau, Germany. 20. Pahr Sandra: Weizen: Nahrungsmittel und Allergieauslöser. Sitzung des Verbandes der österreichischen Mühlenindustrie, February 26, 2014, Vienna, Austria 21. Pahr Sandra: Wheat allergy: Diagnosis and Management. United European Gastroenterology Week (UEG Week) 2014, October 19, 2014, Vienna, Austria 22. Valenta Rudolf: 1. ASA-NET Treffen: “Asthma: Fokus IgE”. June 6, 2014, Paracelsus Medizinische Privatuniversität, Salzburg, Austria. 23. Valenta Rudolf: 14th International Paul Ehrlich Seminar: “Allergen Products for Diagnosis and Therapy: Regulation and Science”. October 29 – November 1, 2014, Hotel Dolce, Bad Nauheim, Germany. 24. Valenta Rudolf: 1st Congress of allergists and clinical immunologists of the Rebublic of Kazakhstan, XIV International scientific conference “Asthma and Allergy”: “Innovative allergy diagnosis”, “Recombinant allergens for diagnosis and treatment of allergy”. April 24 - 25,.2014, Kazakh National Medical University, Almaty, Kazakhstan. 25. Valenta Rudolf: 6. Wiener Komponentenschule. Allergien besser verstehen: „Pathomechanismen der Allergie“, „Mechanismen der SIT“. August, 29-30, 2014 Vienna, Austria. 26. Valenta Rudolf: Advisory board meeting, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, St. Mary´s Campus. January, 30-31, 2014, London, United Kingdom. 27. Valenta Rudolf: ALLSA Congress 2014, Frontiers in Allergy: “Frontiers in allergy, Cas Motala Memorial Lecture”, “Allergy related immunology for dummies”. August, 6-10, 2014, Durban, South Africa. 28. Valenta Rudolf: Annual retreat of the Centre for Immune Regulation: “From allergen genes to new forms of diagnosis and treatment of allergy”. August, 18-19, 2014, Oslo, Norway. 29. Valenta Rudolf: Bern Immunology Club, Universität Bern, Institut für Pharmakologie: “From allergen genes to new forms of diagnosis and treatment of allergy”. May 21, 2014, Bern, Switzerland.

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

30. Valenta Rudolf: European Academy of Allergy and Clinical Immunology Congress 2014 (EAACI): “Next generation recombinant allergens”. June 7-11, 2014, Copenhagen, Denmark. 31. Valenta Rudolf: European Respiratory Society (ERS), International Congress 2014: “Chair & Opening”, “New therapy options”, “Questions”. September, 6-10, 2014, Bad Homburg, Germany. 32. Valenta Rudolf: Falk Symposium, Celiac disease and other small bowel disorders: „Allergy and the gut“. September 5-6, 2014, Amsterdam, Netherlands. 33. Valenta Rudolf: IDD AII R&D-meeting 2014, Thermofischer Scientific: “The impact of molecular allergy diagnosis on the management of allergic diseases”. September, 15- 16, 2014, Nova Park, Knivsta, Sweden. 34. Valenta Rudolf: International Forum “Clinical Immunology and Allergology – Interdisciplinary Problems”: “Recombinant allergens for diagnosis and treatment of allergy”, “Innovative allergy diagnosis”. May 14-17, 2014, Kazan, Republic of Tatarstan, Russia. 35. Valenta Rudolf: IX World Congress on Immunopathology and respiratory allergy: “Clemens von Pirquet keynote lecture”, “Recombinant allergens for diagnosis and treatment”. October 11, 2014, Dagomys Hotel, Sochi, Russia. 36. Valenta Rudolf: Kurier Gesundheits-Talk, Große Allergie-Diskussion am Mittwoch, March 19, 2014, , Van-Swieten-Saal der MedUni Wien, Vienna, Austria. 37. Valenta Rudolf: Lecture under auspice of Russian Medical Academy for post-graduate education, Medical University of Vienna and INUNIMAI: “Recombinant allergens for diagnosis and treatment of allergy”. October 10, 2014, Holiday Inn, Moscow, Russia. 38. Valenta Rudolf: MeDALL – Mechanisms of the development of allergy, 4th Annual meeting and general assembly: “Characterization of inhalant and food allergens”. January 23, 2014, Paris, France. 39. Valenta Rudolf: Medizin im Museum, Neues aus den medizinischen Gesellschaften im Kunsthistorischen Museum: „Wie funktioniert Allergen-spezifische Immuntherapie und wie können wir dieses Wissen für deren Verbesserung nutzen?“. March 15, 2014, Österreichische Gesellschaft für Allergologie und Immunologie, Vienna, Austria. 40. Valenta Rudolf: Meeting with Stallergenes. February 17, 2014, Paris, Antony, France. 41. Valenta Rudolf: Pharma Forum, Fresenius: “IgE-associated allergy and the rationale for IgE apheresis”. May 6, 2014, Bad Homburg, Germany. 42. Valenta Rudolf: VII World Asthma, Allergy & COPD forum: “Alain de Weck memorial lecture”. April 26-29, 2014, New York, USA. 43. Valenta Rudolf: WAO International Scientific Conference 2014 and the Annual Meeting of the Brazilian Association of Allergy and Immunology: “New Vaccines for Immunotherapy of House Dust Mite Allergy” December 6-9 2014, Rio de Janeiro, Brazil 44. Valenta Rudolf: XXII World Congress of Asthma (WCA 2014): Allergen-specific IgG for the treatment and prevention of allergy”, “Recombinant allergens in asthma management”, “Immunotherapy trials with genetically modified grass pollen allergens”. March 29 – April 1, 2014, Mexico City, Mexico. 45. Vrtala Susanne: 31. Aachener Dermatologenabend und Allergie- und Urtikaria Update,. Komponentenbasierte Allergiediagnostik: Hausstaubmilbe, May 14, 2014, Aachen, Germany. 46. Vrtala Susanne: 5th Retreat Center for Pathophysiology, Infectiology and Immunology, Allergy diagnosis based on microarrayed allergens: the allergen chip, September 16, 2014, Vienna, Austria. 76

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.3.4. Congress organization

Division National congress Intern. Congress, member Name: Name, date Function Name, date Function Valenta Rudolf U.E.M.S Section and Co-organizer Board Meeting, 11/14- 16/2014, Vienna Valenta Rudolf 6. Wiener Co-organizer Komponentenschule, 08/29-30/2014, Vienna Valenta Rudolf 3rd SFB work-in- Organizer progress meeting of the Special Research Program SFB F46-B19 "Towards prevention and therapy of allergy", Ottenstein, Austria, 09/19/2014 – 10/02/ 2014 Valenta Rudolf Landsteiner Seminar Organizer "Antibodies in HIV-1 prevention, immunity and therapy", Ges. der Ärzte, Billrothhaus, Vienna, 03/21/2014 Vrtala Susanne CD-Evaluierung Organizer MUW, 02/20/2014

1.3.5. Hosting speakers division member Speaker´s name Affiliation Date Valenta Rudolf Prof. Mayte Villalba Dept. of Biochemistry& Molecular 01/21/2014 Biology, Complutense University, Madrid, Spain Valenta Rudolf Prof. Stephen T Faculty of Medicine, 02/21/2014 Holgate Clinical&Experimental Sciences Academic Unit, Southampton General Hospital, Southampton, UK Valenta Rudolf Prof. Markus Ollert Dept. of Dermatology& Allergy, 03/17/2014 Klinikum rechts an der Isar, Techn. Universität München (TUM), Munich, Germany Valenta Rudolf Prof. Michel C. Sherman Fairchild Professor and 03/ 21/2014 Nussenzweig Howard Hughes Medical Institute Investigator at the Rockefeller University and a senior physician at the Rockefeller University Hospital, N. Y. , USA Valenta Rudolf Dr. Juan Rivera National Inst. of 05/23/2014 Arthritis&Musculoskeletal & Skin Diseases, National Inst. of Health, Bethesda, Maryland, USA

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Valenta Rudolf Dr. Gary McLean Cellular&Molecular Immunology 06/06/2014 Research Centre, London Metropolitan University, Hon.Research fellow Airways Disease Infection Imperial College London, UK Valenta Rudolf Dr. Jiu-Yao Wang Dept. of Pediatrics, Div. of Allergy, 06/12/2014 Immunology&Rheumatology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan, President TAPAACI Valenta Rudolf Ass. Prof. Richard Universität Salzburg, Fachbereich 07/21/2014 Weiss Mol. Biologie, Abt. Allergie & Immunologie, Salzburg Valenta Rudolf Dr. Alexander Inst. of Immunology, University of 08/01/2014 Eggel Bern, Inselspital, Bern, Switzerland Valenta Rudolf Dr. Gabriela Senti Head of Clinical Trials Center ZKF, 08/21/2014 University Hospital Zürich, Switzerland Valenta Rudolf Dr. Thomas Kündig Head of Research, Dept. of 08/21/2014 Dermatology, University Hospital Zürich, Switzerland Valenta Rudolf Dr. Kentaro Research Center of Allergy & Clinical 10/02//2014 Takahashi Immunology, Asahi General Hospital, Asahi, Japan Valenta Rudolf Prof. Ruby Prof. of Allergy, Dept. of Pediatrics, 10/20/2014 Pawankar Nippon Medical School, Tokyo, Japan Valenta Rudolf Dr. David Research Dir. from Inserim, 10/20/2014 Dombrowicz InserimU1011&USDL, Univ. Lille, Inst. Pasteur de Lille, Lille, France Valenta Rudolf Prof. Hans-Uwe Prof. for Pharmacology& Dir. of the 10/20/2014 Simon Dept.of Pharmacology, Vice-Dean for Reseach of the Med. Faculty, University of Bern, Switzerland Valenta Rudolf Prof. Peter Prof. of Experimental Medicine, 10/20/2014 Openshaw Director, Centre for Respiratory Infections, Faculty of Medicine, Nat. Heart&Lung Inst., Imperial College London, UK Valenta Rudolf Prof. Ulrich Wahn Chief Editor, Pediatric Allergy and 10/20/2014 Immunology (PAI), Dir.emeritus of the Dept. for Pediatric Pneumology& Immunology, Charité, Berlin, Germany Valenta Rudolf Prof. Nikolaos G Prof. of Allergy & Pediatric Allergy, 10/20/2014 Papadopoulos Center for Pediatrics and Child Health, Inst. of Human Development, The Univ. of Manchester, UK, Head of Allergy Dept. 2nd Pediatric Clinic, Assoc. Prof. of Allergy and Ped. Allergy, Medical School, Univ. of Athens, Greece Valenta Rudolf Prof. Thomas Dept. of Dermatology&Allergy, Head 10/20/2014 Werfel of the Research Div. of Immunodermatology& Allergy Research, Hannover Medical Univ., Germany

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Valenta Rudolf Assoc. Prof. Assoc. Prof. in Gen. Pathology, Dept. 10/20/2014 Francesco of Experimental & Clinical Medicine, Annunziato Univ. of Florence, Dir. of the Regenerative Therapy S.O.D. Azienda Ospedaliero Universitaria Gareggi, AOUC, Florence, Italy Valenta Rudolf Prof. Inger Sandlie Centre for immune regulation, Dept. 12/15/2014 of Biosciences, University of Oslo, Norway Valenta Rudolf Associate Prof. Chief, Pediatric Allergy& 12/17/2014 Wayne Shreffler Immunology, PI, Center for Immunology&Inflammatory Diseases, MassGeneral Hospital for Children, Boston, USA Valenta Rudolf Prof. Dr. Friedrich VCC, Gesellschaft zur Durchführung 11/15/2014 Horak und Dokumentation biologischer Studien, Austria Valenta Rudolf Dr. Petra VCC, Gesellschaft zur Durchführung 11/15/2014 Zieglmayer und Dokumentation biologischer 08/29/2014 Studien, Austria Valenta Rudolf Doz. Dr. Christine Landesklinikum St. Pölten, Abteilung 08/29/2014 Hafner für Haut undGeschlechtskrankheiten Valenta Rudolf Dr. Thomas MedUni Wien-AKH Wien, Abteilung 08/29/2014 Eiwegger für Kinder- und Jugendheilkunde Valenta Rudolf Doz. Mag. Dr. Floridsdorfer Allergiezentrum 08/29/2014 Stefan Wöhrl Valenta Rudolf Prof. Werner Meduni Graz, Universitätsklinik für 08/29/2014 Aberer Dermatologie und Venerologie Valenta Rudolf Prof. Dr. Verena MedUni Wien-AKH Wien, Univ.-Klinik 08/30/2014 Niederberger für HNO Valenta Rudolf Prof. Dr. Heimo MedUni Wien-AKH Wien, Abteilung 08/29/2014 Breiteneder für Medizinische Bio-technologie Vrtala Susanne Jon-Sverre VP Global R&D at Thermo Fisher 02/20/2014 Schance Scientific (Phadia), Schweden Vrtala Susanne Rainer Henning Chief Executive Officer, Fa. Biomay 02/20/2014 AG, Vienna

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.3.6. Mobility

Name Program University, Time frame Division In Out Country Marques Grilo EAACI research grant Portugal 06/11/2014 – 3 X Andreia 02/28/2015 Lurger Kristina Praktikantin Austria 10/06/2014 – 3 X 10/31/2014 Lampros Hellenic Society of 06/25/2014 – 3 X Kalogiros Allergology and 09/20/2014 clinical Immunology Garib Viktoriya Visiting scientist University of 01/01/2014 – 3 X Uzbekistan 09/18/2014 Vacal Phyllis Trainee Saint Mary’s 09/01/2014 – 3 X University, 05/28/2014 Bayombong, Nueva Vizcaya, Philippines Marusciac Trainee Romania 02/17/2014 – 3 X Laura 02/21/2014 Marth Visiting scientist Austria 01/01/2014 – 3 X Katharina 12/31/2014 Flicker Sabine Karl-Franzens- 10/01/2014 – 3 X Universität Graz, 12/31/2014 Inst. für Molekulare Biowissenschaften Nazanin Najafi Kooperation zur HelmholzZentrum 10/31/2014 – 3 X Herstellung München 11/22/2014 rekombinanter Allergen-spezifischer IgE Antikörprer Gadermaier The Rockefeller 08/25/2014 – 3 X Elisabeth University, New 08/30/2014 York, USA

1.3.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Rudolf Valenta Iranian Journal of Allergy, International Board Consultant Asthma and Immunology”

1.3.8. Editorial Activities

Name Journal Function Rudolf Valenta International Archives of Allergy Editor in Chief and Immunology Rudolf Valenta International Archives of Allergy Editorial Board and Immunology Rudolf Valenta ACI International Editorial Board Rudolf Valenta Allergo Journal Editorial Board

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Rudolf Valenta Journal of Investigational Editorial Board Allergology & Clinical Immunology Rudolf Valenta European Journal of Clinical Editorial Board Investigation Rudolf Valenta Calcium Binding Proteins Editorial Board Rudolf Valenta International Journal of Editorial Board Immunorehabilitation Rudolf Valenta American Journal of Plant Editorial Board Sciences Rudolf Valenta Revista Alergia Mexico Editorial Board Rudolf Valenta Clinical Reviews in Allergy and Editorial Board Immunology

1.3.9. Review Activities

Name Grants/Thesis/Habilitation Valenta Rudolf Review of the diploma thesis “From mechanisms of food allergy to new forms of diagnosis and treatment” by Antonia Charis Gstöttner Valenta Rudolf Review of the diploma thesis: Expression and purificatuion of recombinant surface proteins G and F of Human Respiratory Syncytial Virus (HRSV) by Kristina Borochova

1.3.10. Filed and granted patents

Name Patent Patent No. Filed Granted Valenta Rudolf Nutritional Formulation EP2332428(B1) 08/20/2014 comprising a cow’s milk peptide- containing hydrolysate and/or peptides derived thereof for tolerance induction Valenta Rudolf Peptide Carrier Fusion Proteins MX2013014439 07/24/2014 as Allergy Vaccines (A) Valenta Rudolf Vaccine Carrier JP2014087341 05/15/2014 (A) Valenta Rudolf Hypoallergenic hybrid ES2463828 (T3) 05/29/2014 polypeptides for the treatment of allergy Valenta Rudolf Immunoaffinity separation EP2696895(A1) 02/19/2014 materials comprising Anti-IgE antibody derivatives Valenta Rudolf Immunoaffinity separation US2014124448 05/08/2014 materials comprising Anti-IgE (A1) antibody derivatives Valenta Rudolf Hypoallergenic mutant US2014121356 05/01/2014 polypeptides based on fish (A1) parvalbumin Valenta Rudolf Method for diagnosing a viral WO2014140332 09/18/2014 infection (A1) Valenta Rudolf Wheat antigens and peptides for US2014037667 02/06/2014 Diagnosis of Wheat Induced (A1)

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Hypersensitivity Valenta Rudolf Hypallergenic mosaic antigens US08709435 (B2) 04/29/2014 and methods of making same Valenta Rudolf Hypoallergenic hybrid EP2475386 04/09/2014 polypeptides for the treatment of allergy Valenta Rudolf Hypoallerg. Polypeptides for the EP2646460 11/05/2014 treatment of house dust mite allergy Valenta Rudolf Method for reducing EP2014/053563 02/24/2014 immunoglobulin E(lgE) Valenta Rudolf Japan, Phadia AB 5542685 05/16/2014

1.3.11. Grants

Funding agency Title of project Principal investigator Biomay Produktions- Impfstoffe und Toleranzstrategien für Typ I Rudolf Valenta und Handels- Alllergie. Aktiengesellschaft (RV), AP00085OFF AS00000017 Abgeschlossene Projekte § 26 Rudolf Valenta EU-Kommission/FP7 EU Projekt MedAll - Mechanisms of the Rudolf Valenta „Health“, FA648A0304 development of allergy. EU-Kommission/FP7 EU Projekt Predicta - Post-infectious immune Rudolf Valenta „Health“, FA648A0303 reprogramming and its association with persistence and chronicity of respiratory allergic diseases. Fresenius Medical Extracorporal Specific IgE Removal from the Rudolf Valenta Care Deutschland plasma of allergic Asthma patients. GmbH., ESPIRA, FA648A0305 Karger Verlag, Editorial Office, Personalkosten, Sachkosten. Rudolf Valenta UE64801005 Fonds zur Förderung PHD-Program „Inflammation and Immunity“. Rudolf Valenta Wissenschaftlicher Forschung (FWF) MUW PHD-Program „Inflammation and Immunity“, Rudolf Valenta Rudolf Valenta Fonds zur Förderung PhD-Program Molecular, Cellular and Clinical Rudolf Valenta Wissenschaftlicher Allergology, MCCA. Forschung (FWF) Fonds zur Förderung PhD-Program Molecular, Cellular and Clinical Susanne Vrtala Wissenschaftlicher Allergology, MCCA. Forschung (FWF) Fonds zur Förderung PhD-Program Molecular, Cellular and Clinical Margarete Focke-Tejkl Wissenschaftlicher Allergology, MCCA. Forschung (FWF) FWF, 23318-B11, Regulatory role of allergen-specific antibodies. Sabine Flicker APP23318FW FWF, 23350-B11, Recognition of allergen epitopes in secondary Birgit Linhart APP23350FW IgE response. Christian Doppler Development of allergen chips. Susanne Vrtala Research Association FWF-SFB F4601-B19, Coordination project, „Towards prevention and Rudolf Valenta APF04601FW therapy of allergy“ Rudolf Valenta FWF-SFB F4605-B19, “Towards prophylactic vaccination of allergy”. Rudolf Valenta APF04605FW FWF-SFB F4602-B19, “Strategies for diagnosis, treatment and Susanne Vrtala 82

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

APF04602FW prevention of house dust mite allergy “. FWF-SFB F4607-B19, Allergen specific antibodies for therapy and Sabine Flicker APF04607FW prevention of allergy. European Research Towards safe and effective immunotherapy of Birgit Linhart Grant - FP7 – Seventh persistent life-threatening food allergies. Framework, FA648A1101 Bundesministerium für Towards safe and effective immunotherapy of Birgit Linhart Wissenschaft und persistent life-threatening food allergies. Forschung, EU Zusatzfinanzierung für 7. Rahmenprogramm, FA648A1102 FWF, P 25921-B21, New forms of diagnosis and treatment. Heidrun Hochwallner APP25921FW SA648A0005 Abgeschlossene Projekte § 27 Rudolf Valenta Kooperation mit Bestimmung spezifischer IgE Antikörper & Rudolf Valenta Phadia Austria GmbH Seren m ISAC Chips.

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.3.12. Career Developments a) Habilitations: n = 2 1. Linhart Birgit : Habilitation: Impfstoffe für die allergenspezifische Immuntherapie 15.10.2014 2. Mittermann Irene: Habilitation: Von der Molekularen und Immunologischen Charakterisierung von Allergenen zur Diagnose von Allergien 15.10.2014

b) Habilitations in progress: n = 0

c) Professorships: n = 0

1.3.13. Teaching a) Bachelor students: n = 0

b) Diploma, MDiploma and Master students: n = 2 1. Borochova Kristina: Master thesis: Expression and purification of human respiratory sxncytial virus recombinant surface proteins F and G (2013 – 9/2014) 2. Gstöttner Antonia: Master thesis, From mechanisms of food allergy to new forms of diagnosis and treatment (2012 – 9/2014).

c) PhD, MDSci, MD students: n = 16 1. Banerjee Srinita: PhD thesis: Production and evaluation of peptide vaccines for house dust mite immunotherapy (2009-10/2014). 2. Borochova Kristina: PhD thesis: Immune recognition of RSV antigens and epitopes (10/2014 – in progress)

3. Cornelius Carolin: PhD thesis: Characterization of immune responses towards Hepatitis B virus antigens and epiTopes (2012 – in progress). 4. Dorofeeva Yulia: PhD thesis: Peptide-carrier vaccines for the treatment of allergy to Parietaria pollen (10/2014 – in progress). 5. Dzoro Sheron: PhD student: “Characterisation of antibody reactive microbial antigens”, (2013 – in progress). 6. Freidl Raphaela: PhD thesis: Novel approaches for allergen-specific immunotherapy (2/2014 – in progress) 7. Gallerano Daniela: PhD thesis, Towards the definition of HIV-related anitbody- signatures and new immunogens for vaccine design (2009 – in progress). 8. Gattinger Pia: PhD thesis: Biological role of IgE-reactive carbohydrates (10/2014 – in progress) 9. Huang Huey-Jy: PhD thesis: Identification of the dominant T cell and B cell epitopes of important HDM allergens (2013 – in progress). 10. Kodydek Mary: PhD thesis: Identification of peptides from the major peanut allergens 84

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

for the induction of allergen-specific protective IgG antibodies with diminished IgE or T- cell reactivity (2013 – in progress). 11. Madritsch Christoph: PhD thesis: Isolation of grass pollen specific IgE variable regions to study mechanisms of effector cell degranulation (2009 – 12/2014). 12. Narayanan Meena Balakumari: PhD thesis: Mechanisms underlying secondary antibody responses (12/16/2009 – in progress). 13. Nazanin Najafi: PhD thesis: IgE dependent activation of effector cells (2012- in progress). 14. Pahr Sandra: PhD thesis: Characterization of allergens involved in IgE-mediated wheat allergy" passed with distinction (2010- 10/2014). 15. Resch Yvonne: PhD thesis: Characterization of mite allergens (2010-in progress). 16. Rodriguez Dominguez Azahara: PhD thesis: Characterization of house dust mite allergens (10/2014 – in progress)

1.3.14. Exams: n = 5 a) Oral examinations: n = 0

b) Diploma and Thesis-Examinations: n = 4 1. Valenta Rudolf: Antonia Charis Gstöttner, master thesis, 07/29/2014 2. Valenta Rudolf: Christoph Madritsch, PhD thesis examination, 12/10/2014 3. Valenta Rudolf: Kristina Borochova, master thesis, 07/28/2014 4. Vrtala Susanne: Srinita Banerjee, PhD thesis examination, 10/10/2014

c) Exam supervising: n = 1 Vrtala Susanne: Prüfungsaufsicht SIP: 25.6.2014

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

1.3.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2014 Campana Raffaela 2.00 0.40 861046 MCCA Lecture, Thesis Seminar and Basic Course Series on allergic skin diseases Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung Focke-Tejkl Margarete 5.00 1.00 648026 gem. § 13 lit.a StG.) Focke-Tejkl Margarete 2.00 0.11 861007 MCCA Journal Club Focke-Tejkl Margarete 4.00 1.00 648033 Wissenschaftliches Arbeiten Lupinek Christian 2.00 0.40 861046 MCCA Lecture, Thesis Seminar and Basic Course Series on allergic skin diseases Valenta Rudolf 5.00 5.00 648020 Hämatologie - Ausgewählte Kapitel ausFunktioneller Pathologie Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung Valenta Rudolf 5.00 2.00 648026 gem. § 13 lit.a StG.) Valenta Rudolf 4.00 4.00 648027 Pathologie des Herz- und Kreislaufsystems - Ausgewählte Kapitel aus funktioneller Pathologie Valenta Rudolf 4.53 0.20 802000 BL 4 - Funktionssysteme und biologische Regulation Valenta Rudolf 2.00 0.20 860007 Special Course: Scientific Presentation Valenta Rudolf 2.00 0.17 860201 IAI-Journal Club Valenta Rudolf 2.00 0.20 860202 Special Course: Basic techniques in molecular and cellular biology Valenta Rudolf 2.00 0.25 860220 Basisvorlesung Immunologie Valenta Rudolf 2.00 0.11 861007 MCCA Journal Club Valenta Rudolf 2.00 0.15 901929 IAI-Basic Seminars Valenta Rudolf 2.00 2.00 901931 Special Course: Advanced Molecular cloning techniques Valenta Rudolf 2.00 1.00 901941 Special Course: Allergology Valenta Rudolf 2.00 2.00 648024 Journal Club und Progress Report Valenta Rudolf 4.00 1.00 648033 Wissenschaftliches Arbeiten Vrtala Susanne 2.00 0.11 861007 MCCA Journal Club Vrtala Susanne 4.00 1.00 648033 Wissenschaftliches Arbeiten Sum 22.30

WS 2014/15 Flicker Sabine 1.00 0.20 860006 TS: Stimulating Friday Seminar I Flicker Sabine 2.00 0.50 860023 TS B cells and antibodies Focke-Tejkl Margarete 2.00 0.22 861006 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Focke-Tejkl Margarete 2.00 0.13 861007 MCCA Journal Club

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

MCCA Lecture, Thesis Seminar and Basic Course Series on Recombinant Allergens & Focke-Tejkl Margarete 2.00 2.00 861029 Structural Biology Focke-Tejkl Margarete 4.00 1.30 648002 Wissenschaftliches Arbeiten Focke-Tejkl Margarete 2.00 0.66 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Gadermaier Elisabeth 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen Gadermaier Elisabeth 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Gadermaier Elisabeth 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Gallerano Daniela 2.00 2.00 861030 MCCA Lecture, Thesis Seminar and Basic Course Seminar on Viral Infections in Allergy Linhart Birgit 1.00 1.00 800000 Senior-Mentoring Humanmedizin Linhart Birgit 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Linhart Birgit 2.00 0.50 860023 TS B cells and antibodies Lupinek Christian 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen Lupinek Christian 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Mittermann Irene 2.00 0.50 860023 TS B cells and antibodies Niespodziana Katarzyna 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen Niespodziana Katarzyna 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Niespodziana Katarzyna 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Niespodziana Katarzyna 2.00 2.00 861030 MCCA Lecture, Thesis Seminar and Basic Course Seminar on Viral Infections in Allergy Valenta Rudolf 2.00 2.00 648001 Journal Club and Progress Report Valenta Rudolf 4.00 1.30 648002 Wissenschaftliches Arbeiten Valenta Rudolf 5.80 0.40 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Valenta Rudolf 3.00 0.40 840052 Medizinisches Propädeutikum Teil 1 Valenta Rudolf 2.00 0.18 860008 Special Course: Scientific Presentation Valenta Rudolf 2.00 0.22 861006 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Valenta Rudolf 2.00 0.13 861007 MCCA Journal Club Valenta Rudolf 2.00 0.22 861008 MCCA Lecture, Seminar and Course Series on Allergic Priming and Effector Phase Valenta Rudolf 2.00 2.00 861028 MCCA Lecture, Thesis Seminar and Basic Course Series on B-cells & Antibodies MCCA Lecture, Thesis Seminar and Basic Course Series on Recombinant Allergens & Valenta Rudolf 2.00 2.00 861029 Structural Biology Valenta Rudolf 2.00 0.18 870011 Medical Propedeutics ¿ Linking Biology and Diseases - WS 2014/15 Valenta Rudolf 2.00 0.13 901929 IAI-Basic Seminars Valenta Rudolf 2.00 2.00 901931 Special Course: Advanced Molecular cloning techniques Valenta Rudolf 2.00 0.17 902241 IAI-Journal Club Valenta Rudolf 2.00 0.18 902920 Special Course: Basic techniques in molecular and cellular biology

Performance Report 2014 – Division 2 Cellular and Molecular Pathophysiology

Vrtala Susanne 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen Vrtala Susanne 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Vrtala Susanne 2.00 0.44 861006 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Vrtala Susanne 2.00 0.13 861007 MCCA Journal Club MCCA Lecture, Thesis Seminar and Basic Course Series on Recombinant Allergens & Vrtala Susanne 2.00 2.00 861029 Structural Biology Vrtala Susanne 4.00 1.30 648002 Wissenschaftliches Arbeiten Vrtala Susanne 2.00 0.66 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Sum 32.94 Total sum SS+WS 55.24

Performance Report 2014 – Division 4 Medical Biotechnology

1.4 Division for Medical Biotechnology Head: Heimo Breiteneder, Professor

1. Publications8 IF Number Top/Std/Subst Heimo Breiteneder 41.429 9 4 Top, 4 Std, 1 Subst Karin Hoffmann-S. 16.327 10 10 Top Yan Ma 4.350 2 2 Std Christian Radauer 22.152 3 3 Top Division-Sum 57.758 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Heimo Breiteneder 5 Karin Hoffmann-S. 1 3 Yan Ma 1 Christian Radauer 1 1 1 Sum 1 2 10

3. Teaching SS* WS* total W+S oral Exams Heimo Breiteneder 3.78 8.17 11.95 0 Merima Bublin 1.00 0.53 1.53 0 Karin Hoffmann-S. 1.32 5.62 6.94 20 Yan Ma 4,81 8,75 13.56 26 Christian Radauer 1.53 1.53 0 Sum 10.91 24.6 35.51 44

8 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications.

Performance Report 2014 – Division 4 Medical Biotechnology

1.4.1. Publications a) Peer-reviewed original articles: n = 9

Nr. Article IF Class pro-rata IF 1. Burney PG, Potts J, Kummeling I, C Mills EN, Clausen M, 5.995 TOP 1.199 Dubakiene R, Barreales L, Fernandez-Perez C, Fernandez- Rivas M, Le TM, Knulst AC, Kowalski ML, Lidholm J, Ballmer- Weber BK, Braun-Fahlander C, Mustakov T, Kralimarkova T, Popov T, Sakellariou A, Papadopoulos NG, Versteeg SA, Zuidmeer L, Akkerdaas JH, Hoffmann-Sommergruber K, van Ree R. The prevalence and distribution of food sensitization in European adults. Allergy 2014; 69(3):365-71.

2. Palmberger D, Ashjaei K, Strell S, Hoffmann-Sommergruber 3.708 TOP 0.742 K, Grabherr R. Minimizing fucosylation in insect cell-derived glycoproteins reduces binding to IgE antibodies from the sera of patients with allergy. Biotechnol J. 2014; 9(9):1206-14.

3. Smith M, Jäger S, Berger U, Šikoparija B, Hallsdottir M, 5.995 TOP 5.995 Sauliene I, Bergmann, K-Ch, Pashley C H, de Weger L, Majkowska-Wojciechowska B, Rybníček O, Thibaudon M, Gehrig R, Bonini M, Yankova R, Damialis A, Vokou D, Gutiérrez Bustillo A M, Hoffmann-Sommergruber K and van Ree R. Geographic and temporal variations in pollen exposure across Europe Allergy. 2014; 69(7):913-23

4. Moraes AH, Ackerbauer D, Kostadinova M, Bublin M, de 2.926 SSt 0.585 Oliveira GA, Ferreira F, Almeida FC, Breiteneder H and Valente AP. Solution and high-pressure NMR studies of the structure, dynamics, and stability of the cross-reactive allergenic cod parvalbumin Gad m 1. Proteins 2014; 82(11):3032-42.

5. Gepp B, Lengger N, Bublin M, Hemmer W, Breiteneder H 11.248 TOP 11.248 and Radauer C. Chimeras of Bet v 1 and Api g 1 reveal heterogeneous IgE responses in patients with birch pollen allergy. J Allergy Clin Immunol 2014; 134(1):188-94. doi: 10.1016/j.jaci.2013.

6. Guhsl EE, Hofstetter G, Hemmer W, Ebner C, Vieths S, Vogel 4.909 TOP 4.909 L, Breiteneder H and Radauer C. Vig r 6, the cytokinin-specific binding protein from mung bean (Vigna radiata) sprouts, cross- reacts with Bet v 1-related allergens and binds IgE from birch pollen allergic patients' sera. Mol Nutr Food Res. 2014; 58(3):625-34.

7. Lupinek C, Wollmann E, Baar A, Banerjee S, Breiteneder H, 3.221 Std 0.644 Broecker BM, Bublin M, Curin M, Flicker S, Garmatiuk T, Hochwallner H, Mittermann I, Pahr S, Resch Y, Roux KH, Srinivasan B, Stentzel S, Vrtala S, Willison LN, Wickman M, Lødrup-Carlsen KC, Antó JM, Bousquet J, Bachert C, Ebner D, Schlederer T, Harwanegg C and Valenta R. Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip. Methods. 2014;

Performance Report 2014 – Division 4 Medical Biotechnology

1;66(1):106-19.

8. Liu J, Peter K, Shi D, Zhang L, Dong G, Zhang D, Breiteneder 2.175 Std 2.175 H, Bauer R, Jakowitsch J and Ma Y. Anti-inflammatory effects of the chinese herbal formula sini tang in myocardial infarction rats. Evid Based Complement Alternat Med. 2014; 2014:309378.

9. Liu J, Peter K, Shi D, Zhang L, Dong G, Zhang D, Breiteneder 2.175 Std 2.175 H, Jakowitsch J, Ma Y. Traditional formula, modern application: chinese medicine formula sini tang improves early ventricular remodeling and cardiac function after myocardial infarction in rats. Evid Based Complement Alternat Med. 2014; 2014:141938. sum 29.672

b) Invited Articles & Reviews with IF: n = 10

Nr. Article IF Class pro-rata IF 1. Nwaru BI, Hickstein L, Panesar SS, Roberts G, Muraro A, 5.995 TOP 1.199 Sheikh A, EAACI Food Allergy and Anaphylaxis Guidelines Group. Prevalence of common food allergies in Europe: a systematic review and meta-analysis. Allergy 2014; 69(8):992- 1007

2. de Silva D, Geromi M, Halken S, Host A, Panesar SS, Muraro 5.995 TOP 1.199 A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AE, Poulsen LK, Van Ree R, Vlieg- Boerstra B, Agache I, Grimshaw K, O'Mahony L, Venter C, Arshad SH, Sheikh A. Primary prevention of food allergy in children and adults: systematic review. Allergy 2014; 69(5):581-9.

3. Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel 5.995 TOP 1.199 T, Hoffmann-Sommergruber K, Roberts G,Halken S, Poulsen L, van Ree R, Vlieg-Boerstra BJ, Sheikh A, on behalf of the EAACI Food Allergy and Anaphylaxis Guidelines Group. The diagnosis of food allergy: a systematic review and meta- analysis. Allergy 2014; 69: 76–86.

4. de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T, 5.995 TOP 1.199 Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AE, Halken S, Host A, Poulsen LK, Van Ree R, Vlieg-Boerstra BJ, Agache I and Sheikh A, EAACI Food Allergy and Anaphylaxis Guidelines Group. Acute and long-term management of food allergy: systematic review. Allergy 2014; 69(2):159-67.

5. Salvilla SA, Dubois AEJ, Flokstra-de Blok BMJ, Panesar SS, 5.995 TOP 1.199 Worth A, Patel S, Muraro A, Halke S, Hoffmann- Sommergruber K, Dunn-Galvin A, O’Hourihane J, Regent L, de Jong NW, Roberts G, Sheikh A. Disease-specific health related quality of life instruments for IgE mediated food allergy. Allergy 2014; 69(7):834-44.

Performance Report 2014 – Division 4 Medical Biotechnology

6. Muraro A, Hoffmann-Sommergruber K, Holzhauser T, 5.995 TOP 1.199 Poulsen LK, Gowland MH, Akdis CA, Mills EN, Papadopoulos N, Roberts G, Schnadt S, van Ree R, Sheikh A, Vieths S, EAACI Food Allergy and Anaphylaxis Guidelines. Protecting consumers with food allergies: understanding food consumption, meeting regulations and identifying unmet needs. EAACI Food Allergy and Anaphylaxis Guidelines Group. Allergy 2014; 69(11):1464-72.

7. Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, 5.995 TOP 1.199 Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, Fernandez Rivas M, Halken S, Hickstein L, Høst A, Knol E, Lack G, Marchisotto MJ, Niggemann B, Nwaru BI, Papadopoulos NG, Poulsen LK, Santos AF, Skypala I, Schoepfer A, Van Ree R, Venter C, Worm M, Vlieg-Boerstra B, Panesar S, de Silva D, Soares-Weiser K, Sheikh A, Ballmer- Weber BK, Nilsson C, de Jong NW , Akdis CA ,EAACI Food Allergy and Anaphylaxis Guidelines Group. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy 2014; 69(8):1008-25.

8. Bublin M. Eiwegger T and Breiteneder H. Do lipids influence 11.248 TOP 11.248 the allergic sensitization process?. J Allergy Clin Immunol 2014; 134(3): 521-529.

9. Bublin M and Breiteneder H. Cross-Reactivity of Peanut 2.450 St 2.450 Allergens. Curr Allergy Asthma Rep 2014; 14(4):426.

10. Radauer C, Nandy A, Ferreira F, Goodman R E, Larsen J N, 5.995 TOP 5.995 Lidholm J, Pomes A, Raulf-Heimsoth M, Rozynek P, Thomas W R and Breiteneder H. Update of the WHO/IUIS Allergen Nomenclature Database based on analysis of allergen sequences. Allergy2014; 69: 413-419. sum 28.086

c) Invited Articles & Reviews without IF: n = 1

1. Ladics GS, Fry J, Goodman R, Herouet-Guicheney C, Hoffmann-Sommergruber K, Madsen CB, Penninks A, Pomés A, Roggen EL, Smit J and Wal J-M. Allergic sensitization: screening methods. Clin Transl Allergy 2014; 4:13; 15;4(1):13.

d) Book contributions: n = 8

1. Breiteneder H, Mills ENC. Food allergens – Molecular and immunological characteristics. In: “Food Allergy: Adverse Reactions to foods and food additives.” Fifth Edition (Eds: Metcalfe DD, Sampson HA, Simon RA, Lack G). Wiley Blackwell 2014, pp 47-67.

2. Breiteneder H. Mechanisms of allergenicity of allergens. In: “Global Atlas of Allergy”(Eds. Akdis CA, Agache I). European Academy of Allergy and Clinical Immunology 2014, pp 9-10.

Performance Report 2014 – Division 4 Medical Biotechnology

3. Breiteneder H, Chapman MD. Allergen nomenclature. In: “Allergens and Allergen Immunotherapy. Subcutaneous, sublingual and oral.” Fifth Edition. (Eds. Lockey RE, Ledford DK). CRC Press 2014, pp 37-50.

4. K. Hoffmann-Sommergruber: „Kommentar zum Beitrag: Sellerie-Beifuß-Gewürz- Syndrom im Visier: auf der Suche nach den verantwortlichen Kreuzallergenen“ und Kommentar zum Beitrag: Neu beschriebenes Lipid-Transfer-protein in der Heidelbeere: Mitglied einer Allergenfamilie mit erhöhtem Risiko für systematische Reaktionen. In Molekulare Allergologie Herausgeber: J. Kleine-Tebbe und U. Jappe, Dustri Verlag Feistle München -Deishofen, 2014

6. K. Hoffmann-Sommergruber: „Emerging Allergens“ In: “Global Atlas of Allergy”(Eds. Akdis CA, Agache I). European Academy of Allergy and Clinical Immunology 2014, pp 34-35.

7. Barbara K. Ballmer-Weber, K. Hoffmann-Sommergruber. Update: molekulare Diagnose der Gemüse- und Fruchtallergie. Allergo J. 2014; 23:24: 39-49

8. Yan Ma: Was sind Chinesische Medizin und Chinesische Kultur? In: „Kinderuni Wien 2014. Studienbuch S96“ Vienna General Hospital, Medical University of Vienna, July 14th-17th 2014

e) Abstracts, printed in periodicals: n = 1

1. Gepp, B., N. Lengger, C. Radauer, F. Gruber, M. Mildner, H. Breiteneder. The major birch pollen allergen Bet v 1 binds lipids from birch and grass pollen but not from peanuts. Allergy, Volume: 69; Supp.: 99. EAACI Congress, June 7-11, Copenhagen, Denmark. 2014.

f) Abstracts, in congress proceedings or abstract books: n = 19

1. Hoffmann-Sommergruber, K., S. Pfeifer, P. Dubiela, A. Spiller, C. Hafner, M. Bublin. Allergen food matrix interaction – impact on allergenicity. 30th Symposium of the Collegium Internationale Allergologicum: “Petersberg, Germany, 13. -18.9.2014..

2. Pfeifer, S., P. Dubiela, M. Bublin, C. Hafner, K. Hoffmann-Sommergruber. Purification and characterization of natural Cor a 14, the 2S albumin from hazelnut, and its isoforms. FAAM Meeting, Dublin, October 9-11, 2014.

3. Dubiela, P., S. Pfeifer, M. Bublin, C. Hafner, K. Hoffmann-Sommergruber. The non- specific lipid transfer protein from hazelnut, Cor a 8, a relevant food allergen. FAAM Meeting, Dublin, October 9-11, 2014.

4. Pfeifer, S. Purification and characterization of important food allergens – Hazelnut as a model. SFB Work in Progress Meeting, Ottenstein, Austria, October 19-21, 2014.

5. Dubiela, P., S. Pfeifer, M. Bublin, C. Hafner, K. Hoffmann-Sommergruber. Cor a 8 displays reduced stability upon heat and digestion treatment. ÖGAI Jahrestagung, Salzburg, November 5-8, 2014.

6. Pucciarelli, D., S. Kontsekova, N. Lengger, C. Hafner, H. Breiteneder. Anti-CSPG4- specific antibodies enhance the effects of the BRAF inhibitor PLX4032 on melanoma cells. XXII International pigment cell conference, Singapore, September 4-7, 2014.

Performance Report 2014 – Division 4 Medical Biotechnology

7. Kontsekova, S., D. Pucciarelli, N. Lengger, H. Breiteneder, S. Pastorekova, C. Hafner. Cspg4 expressed by 518A2 melanoma cells is shedded by matrix metallopeptidases after PLX4032 treatment in normoxic and hypoxic conditions. 5th Centrum Retreat, Vienna, September 16, 2014.

8. Pfeifer, S., P. Dubiela, M. Bublin, K. Hummel, C. Hafner, K. Hoffmann- Sommergruber. Stability and micro-heterogeneity of Cor a 14, the 2S albumin from hazelnut. ÖGAI Jahrestagung 2014, Salzburg, November 5-7, 2014.

9. He, S., M. Xue, T. Manhardt, L. Yang, D. Shi, C. Radauer, H. Breiteneder, E. Kallay, Y. Ma. Quality control and anti-cancer activity evaluation of panax quinquefolius saponins. The Young Scientist Association (YSA) of the Medical University of Vienna 2014

10. He, S., T. Manhardt, M. Xue, D. Shi, L. Liu, C. Radauer, H. Breiteneder, E. Kallay, Y. Ma. Anti-cancer activity evaluation and quality control of Panax quinquefolius saponins. 5th Retreat Center for Pathophysiology, Infectiology and Immunology 2014, Vienna, September 16, 2014.

11. Gepp, B., N. Lengger, C. Radauer, F. Gruber, M. Mildner, H. Breiteneder. The sensitization potential of the major birch pollen allergen Bet v 1 may arise from its ability to transport lipids. 5th CePII Retreat – Vienna, Austria, September 16, 2014.

12. Gepp, B., N. Lengger, C. Radauer, F. Gruber, M. Mildner, H. Breiteneder. Bet v 1 - from sensitization to IgE epitope mapping. SFB Work in Progress Meeting – Ottenstein, Austria, October 20-21, 2014.

13. Gepp, B., N. Lengger, C. Radauer, F. Gruber, M. Mildner, H. Breiteneder. Phosphorylation of CREB is upregulated in keratinocytes after treatment with the major birch pollen allergen, Bet v 1, and birch pollen lipids. ÖGAI Jahrestagung - Salzburg, November 6th – 8th, 2014.

14. Pucciarelli, D., M. Takáčová, L. Csaderova, F. Juliano, N. Lengger, H. Breiteneder, S. Pastorekova, C. Hafner. Hypoxia influences the response to vemurafenib of V600E mutant melanoma cells. Annual Meeting of the American Association for Cancer Research, San Diego, California, USA; April 5-9, 2014.

15. Pucciarelli, D., M. Takáčová, L. Csaderova, F. Juliano, N. Lengger, H. Breiteneder, S. Pastorekova, C. Hafner. The response to Vemurafenib is influenced by hypoxia in V600E mutant melanoma cells. YSA-PhD Symposium, Medical University of Vienna; June 11-12, 2014.

16. Pucciarelli, D., N. Lengger, M. Takáčová, L. Csaderova, H. Breiteneder, S. Pastorekova, C. Hafner. The Response to Vemurafenib in V600E Mutatnt Melanoma Cells is modified by hypoxia. - 5th Retreat of the Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna; September 17, 2014.

17. Pucciarelli, D., N. Lengger, M. Takáčová, H. Breiteneder, S. Pastorekova, C. Hafner. Hypoxia contributes to melanoma phenotype change by affecting the response to vemurafenib. - ÖGAI Annual Meeting 2014, Salzburg, Austria; November 6-8, 2014.

18. Brecker, L., K. Peter, J. Schinnerl, S. Felsinger, Y. Ma. Using NMR spectroscopy to find a “lost” toxic compound in an unexpected molecular complex. 29th NMR VALTICE Meting, Valtice, Tschechien ; April 27-30, 2014.

Performance Report 2014 – Division 4 Medical Biotechnology

19. He, S., M. Xue, T. Manhard, L. Yang, D. Shi, C. Radauer, H. Breiteneder, E. Kallay, Y. Ma. Quality control and anti-cancer activity evaluation of panax quinquefolius saponins. 4th YSA PhD Symposium, Medical University of Vienna, June 11-12, 2014.

g) Teaching Scripts and Books, n = 50

Breiteneder Heimo: Immunobiology and Vascular Diseases (cooperation for “Master Biotechnology” MedUni and BOKU) VO 881.004/791.363, SS 2014 1. The world of protein allergens, sources, structures and significance 2. Recognition of microbes and damaged self (Innate Immunity 1) 3. Cell-associated pattern recognition receptors (Innate Immunity 2) 4. Soluble recognition and effector molecules (Innate Immunity 3) 5. Cells of the innate immune system (Innate Immunity 4) 6. IgE-mediated allergies 7. Allergens and the innate immune system

MCCA Lecture Series 861.006, WS 2013/2014 (teaching scripts January 2014) 1. Latex allergy 2. Standardization of extracts of allergen sources

MCCA Lecture Series 861.029, WS 2014/2015 (teaching script December 2014) 1. Expression systems: an overview

Hoffmann-Sommergruber Karin: Lehrunterlagen f. d. Vorlesung NM-Allergien und Intoleranzen 514.074 gemeinsam mit Priv. Doz. Dr. Merima Bublin VO 2St. 1. Einführung Immunsystem, Grundlagen und Pathomechanismus der allerg. Reaktion 2. NM-Allergien: Symptome, Prävalenz 3. Allergene 4. Diagnostik von NM-Allergien und Fallbeispiele 5. NM-Intoxikationen, Immunmediierte NM-Allergien – Zöliakie, EOE 6. NM-Intoleranzen 7. NM-Allergien: Genetisch und epigenetische Aspekte; Umwelteinflüsse bei Allergieentstehung, Hygienehypothese 8. Präventionsmaßnahmen: Allergenkennzeichnung, Leitlinien 9. NM-Allergien: Therapieansätze

Lehrunterlagen: (cooperation for “Master Medical Biotechnology” MedUni and BOKU): VO: Infectious Diseases and Vaccine development: 1. Immunology 2. Molecular Biology 3. Bacterial Infections 4. Parasitic Infections 5. Allergy Vaccines 6. Adjuvants 7. Alternative Vaccine development (plant-based) 8. Gene Therapy (Retrovirus) MCCA Lecture Series 861.006, WS 2013/2014 (teaching scripts January 2014) • Food Allergens • Recombinant Food Allergens:Generation, characterization and application; and lab course; Teaching Script Dec 2014)

Performance Report 2014 – Division 4 Medical Biotechnology

Lehrunterlagen f. VO Gender Ring Vorlesung: Genderaspekte bei allergischen Erkrankungen; 29. 4. 2014 (896.022)

Ma Yan: 1. 890.081 Schmerzdiagnostik und invasive Techniken 2. 891.120 Akupunktur-Behandlung und Moxibustion 3. 891.122 Klinische Observation und Praktikum in Österreich 4. 891.113 Einführung in die Medizinische chinesische Fachsprache und Kultur (3) 5. 891.121 Experimentelle Akupunktur 6. 648.004 Einführung in die Traditionelle Chinesische Medizin: Theorie und Praxis (II) 7. 890.048 Lebensqualität, Qualitätsmanagement, Management, Wissenschaftliches 8. 891.109 Einführung in die medizinische chinesische Fachsprache und Kultur (4) 9. 891.110 Chirurgie in der TCM 10. 891.114 Innere Medizin in der TCM 11. 891.117 Orthopädie in der TCM 12. 891.120 Klinische Observation und Praktikum in Österreich

Radauer Christian: Vorlesungsunterlagen zur Vorlesung: Biological Therapeutics (881.000): 1. Structure and function of immunoglobulins 2. Development and production of antibodies 3. Therapeutic full-length mAbs 4. Recombinant antibody derivatives (fragments, bivalent and bispecific antibodies) 5. Antibody conjugates

h) Articles in Medical Journals: n = 0

i) Public Activity: n = 15

Karin Hoffmann-Sommergruber: • Teilnahme an Podiumsdiskussion: „Pollenallergie im Fokus“ 8.4. 2014; Van Swieten Saal Wien. • Lange Nacht der Forschung: 4.4. 2014 Nahrungsmittelallergien. • Pressegespräch: Nahrungsmittelallergien - Gefahr aus dem Kochtopf 6. 5. 2014, 10.00 (IGAV und MedUniWien organisiert). • Interview in Wien Aktuell (Nahrungsmittelallergien) ORF 6. 5. 2014. • Interview in Heute Leben NM-Allergien) ORF, 7. 5. 2014. • Interview im Standard über Allergenspezifische Diagnostik und Immuntherapie (Achtung sie fliegen wieder) Standard Mai 2014. • Podiumsdiskussion: „Allergien – Falscher Alarm des Körpers“ 19. Oktober 2014 Wiener Rathaus/Festsaal – Fem Vital.

Yan Ma: • Einführung in die Traditionelle Chinesische Medizin (TCM). Biologie Veranstaltung des Bundesgymnasiums KREMS - Rechte Kremszeile. Bundesgymnasium KREMS. 2014- 02-19. • Die Rolle der Traditionellen Chinesischen Medizin (TCM) im modernen Europa. Agorà der Universität Salzburg. China-Zentrum an der Paris-Lodron-Universität Salzburg. Sigmund-Haffner-Gasse 18, 5010 Salzburg, 2014-04-29. • Inhalte und Möglichkeiten des Universitätslehrgangs für Traditionelle Chinesische Medizin (TCM). Workshop Med Success 2014. Österreichische Medizinerunion. Medizinische Universität Wien/AKH, 24.05.2015, Wien.

Performance Report 2014 – Division 4 Medical Biotechnology

• Yan Ma, Ulrike Loidl, Carmen Müllauer, Shan He. Traditionelle Chinesische Medizin (TCM) & chinesische Kultur. Workshop Kinderuni Wien/Medizinische Universität Wien. AKH, 2014-07-14 Wien. • Yan Ma, Ulrike Loidl, Carmen Müllauer. Traditionelle Chinesische Medizin (TCM) & chinesische Kultur. Radiointerview OE1 Kinderuni. 2014-07-14, Wien. • Universitätslehrgang für Grundlagen und Praxis der Traditionellen Chinesischen Medizin (TCM). 10-jähriges Jubiläum der MedUni Wien: Zukunfstag MedUni Wien‐postgraduate. Medizinische Universität Wien/AKH, 2014-11-03, Wien. • Gesunde Ernährung aus Sicht der TCM. PE-Seminare: Vortragsreihe: Bewusst gesund@MedUni. Medizinische Universität Wien/AKH, 2014-11-19, Wien.

Pfeifer Sabine: • Lange Nacht der Forschung 2014.

1.4.2. Research Awards: n = 3

Dubiela Pawel: • Poster prize at ÖGAI Salzburg, Nov 2014. • Travel grant for FAAM Meeting (EAACI), October 2014;

Gepp Barbara: • Poster Prize at the Annual Congress of the European Academy of Allergy and Clinical Immunology (EAACI) 2014 – June 7-11, 2014 Copenhagen, Denmark.

1.4.3. Invited lectures: n = 18

Breiteneder Heimo: 1. 10. Wörthersee Symposium What’s new in allergy: “Warum gibt es bei so vielen Proteinen nur so wenige Allergene?“ Velden am Wörthersee, 19.4.2014. 2. Educational and Training Symposium - Clinical aspects of Molecular Allergology: “Protein structure and allergenicity – are they related?” Kazan, Republic of Tatarstan, 16.5.2014. 3. 6. Wiener Komponentenschule; Hotel Courtyard Marriott Wien Messe; „Allergene: Definition, Nomenklatur und Datenbanken“. Wien, 29.8.2014. 4. 30th Symposium of the Collegium Internationale Allergologicum: “Bet v 1 binds lipids from birch and grass pollen but not from peanuts”. Petersberg, Germany, 16.9.2014. 5. 2014 Annual Meeting of the Chinese Society of Allergy: “Do lipids influence the allergenic sensitization process?” Gui Lin, China, 24.10.2014.

Hoffmann-Sommergruber Karin: 1. PRO and CON: EAACI, Need for improved allergy diagnostics, Patients Organisations Committee Workshop; Annual Meeting, Copenhagen: June 9. 2. PRO and CON: EAACI: Molecular diagnosis of fruit and vegetable allergy is ready for the clinic; June, 10, 2014. 3. Update Anaphylaxie Immunodays – (Fortbildungsveranstaltung) 10. 4. 2014, Wien. 4. Grüne Gentechnik: Chance oder Risiko für Gesundheit und Gesellschaft? 5. K. Hoffmann; Podiumsdiskussion im Rahmen des Trinationalen Arabidopsis Meetings; Heidelberg, G, 25. 9. 2014. 6. Molecular allergology (SYMPOSIUM 1) FAAM Meeting, Dublin, 9. – 11. 10. 2014.

Performance Report 2014 – Division 4 Medical Biotechnology

Ma Yan: 1. Einführung in die Traditionelle Chinesische Medizin (TCM). Biologie Veranstaltung des Bundesgymnasiums KREMS - Rechte Kremszeile. Bundesgymnasium KREMS. Februar 19 2014 2. Die Rolle der Traditionellen Chinesischen Medizin (TCM) im modernen Europa. Agorà der Salzburg University. China-Zentrum an der Paris-Lodron-Universität Salzburg. April 29, 2014 3. Inhalte und Möglichkeiten des Universitätslehrgangs für Traditionelle Chinesische Medizin (TCM). Workshop Med Success 2014. Österreichische Medizinerunion. Vienna General Hospital, Medical University of Vienna, May 24, 2014 4. Was sind Chinesische Medizin und Chinesische Kultur? Kinderuni Wien 2013. Vienna General Hospital, Medical University of Vienna, July 14, 2014 5. Universitätslehrgang für Grundlagen und Praxis der Traditionellen Chinesischen Medizin (TCM). 10-jähriges Jubiläum der MedUni Wien: Zukunfstag MedUni Wien- postgraduate. Vienna General Hospital, Medical University of Vienna, Vienna. November 3, 2014 6. Gesunde Ernährung aus Sicht der TCM. PE-Seminare: Vortragsreihe: Bewusst gesund@MedUni. Vienna General Hospital, Medical University of Vienna, Vienna. November 19, 2014

Radauer Christian: 1. Biologische und biochemische Eigenschaften sowie Kreuzreaktionen pflanzlicher Allergene. 7. 5. 2014; 25. Mondseer Gespräche, 7. bis 9. Mai 2014, Mondsee, Österreich

1.4.4. Congress organization

Division member National congress Intern. Congress, Function Function Name: Name, date Name, date Hoffmann- EAACI, Annual Meeting, Chair of 2 OAS Sommergruber Copenhagen: June 9

Karin Hoffmann- EAACI, Annual Meeting, Chair of poster Sommergruber Copenhagen: June, 9 session Karin Hoffmann- FAAM Meeting Dublin Member of Sommergruber Organising Karin Committee Hoffmann- FAAM Meeting Dublin: Chair of poster Sommergruber October, 10 session Karin Hoffmann- FAAM Meeting Dublin: Chair of Sommergruber October, 10 Symposium 6 Karin Hoffmann- ÖGAI Meeting, chair of Sommergruber Salzburg, 6.11.2014 Session 1

Karin

Performance Report 2014 – Division 4 Medical Biotechnology

1.4.5. Hosting speakers

Division member Speaker´s name Affiliation Date Ma Yan Assoc. Prof. Dr. China Academy of Chinese Medical November 11, Mei Xue Sciences 2014

1.4.6. Mobility

Name Program University, Time frame Division In Out Country Coll Llauradó ERASMUS Intership Rovir a i Virgili 01.02.- 4 X Marta University, 30.06.2014 Tarragona, Spain He Shan TCM Jiangsu Province 20.07. - 4 X Academy of 30.07.2014 Traditional Chinese Medicine, Nanjing He Shan TCM Institute if 01.09.- 4 X Chemical 05.09.2014 Technology Prague, Prague Huang Eric (Chi- AMSA Student Taiwan; China 1.7. – 31. 7. 4 X Hsien Huang) Association Medical University 2014 Kontsekova EngCaBra Slovak Academy 07.07.2014- 4 X Sona of Sciences, 18.07.2014 Bratislava Palladino Chiara MCCA Universidad 15.09.- 4 X Complutense de 15.12.2014 Madrid, Madrid Pucciarelli EngCabra Basel, Switzerland 17.03.- 4 X Daniela 21.03.2015 Pucciarelli EngCabra Slovak Academy 15.01.- 4 X Daniela of Sciences, 31.01.2014 Bratislava Valeria EngCabra University of 01.12.- 4 X Fioravanti Bremen, Germany 05.12.2014 René Splinter EngCabra Xenso Interation 17.02. - 4 X bv, Delfgauw, The 21.02.2014 Netherlands Johanna Obacz EngVabra Slovak Academy 14.4.- 4 X of Sciences, 02.05.2014 Bratislava Liu Lu TCM Capital Medical 10.04.- 4 X University 28.06.2014 Filippo Cipriani EngCabra University of Pisa, 12.05.- 4 X Italy 30.05.2014 Mei Xue Visiting scientist China Academy of November 6 4 X Chinese Medical to December Sciences, Beijing, 10, 2014 China

Performance Report 2014 – Division 4 Medical Biotechnology

1.4.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Breiteneder Heimo WHO/IUIS Allergen Head till June 2014, member Nomenclature Sub-Committee Breiteneder Heimo AllFam database Member of the scientific advisory board Breiteneder Heimo SDAP database Member of the scientific advisory board Breiteneder Heimo IGAV Member Hoffmann-Sommergruber Karin IGAV Member Hoffmann-Sommergruber Karin EAACI (European Academy of ExCom Member (IG Allergy and Clinical Representative)

Immunology) Hoffmann-Sommergruber Karin EFSA Working Group Member of Working group “Allergenic risk assessment of GMOs” Hoffmann-Sommergruber Karin COST Action: “Imparas” MC member Hoffmann-Sommergruber Karin Pirquet Club Wissenschaftl. Sekretärin

Hoffmann-Sommergruber Karin ÖGAI (Österr. Gesellschaft f. Vorstandsmitglied Allergologie und Immunologie (Schriftführerin) Ma Yan Consortium for Globalisation of Expert of Education Session Chinese Medicine

Ma Yan World Federation of Chinese Member Medicine Ma Yan Eurasia-Pacific Uninet Member Ma Yan ASEAN-European Academic Member University Network Ma Yan Austrian Society for Medical Member Anthropology Ma Yan The World Federation of Member Chinese Medicine Society Radauer Christian WHO/IUIS Allergen Member Nomenclature Sub-Committee Radauer Christian AllFAm database Project leader, system administrator

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1.4.8. Editorial Activities

Name Journal Function Breiteneder Heimo International Archives of Allergy Member and Immunology Hoffmann-Sommergruber Karin International Archives of Allergy Member and Immunology Ma Yan The international journal TANG Member Ma Yan Evidence-Based Guest Editor Complementary and Alternative Medicine - Special Issue: Traditional Herbal Medicine and Allergic Asthma Ma Yan Evidence-Based Guest Editor Complementary and Alternative Medicine - Special Issue: Evidence-Based TAM Classic Herbal Formula: From Myth to Science

1.4.9. Review Activities

Name Grants/Thesis/Habilitation Breiteneder Heimo Begutachtung einer Bewerbung für die Stelle als Universitäts- professor für „Animal Cell Factory Design“ an der BNOKU Hoffmann-Sommergruber Karin Begutachtung von Projekten der Czech National Science Foundation Hoffmann-Sommergruber Karin Begutachtung PhD Thesis A. Roulias, “Structural manipulations of Bet v 1 homologues and their impact on their immune properties” Hoffmann-Sommergruber Karin Begutachtung Doctoral Thesis: Maria Torres Cabanuz Mai 2014: “Thaumatins and b-1,3-Glucanases: Plant defense protein families and their implications for allergic processes

Ma Yan Begutachtung Master-Thesis Frau Mag. Lin Scheinwein, MSc: “Qigong als Methode in der Alternativ- und Komplementärmedizin bei chronischen obstruktive Atemwegs- und Lungenerkrankungen sowie als ein Instrument zur Gesundheitsprävention – Eine Meta- Analyse“. Medical University of Vienna. Ma Yan Begutachtung Master-Thesis Frau Wenyu Huang, MSc: “Anti- Allergic Effects of Ganoderma lucidum Define a New Prospective for Preventive Treatment of Seasonal Allergic Rhinitis”. Medical University of Vienna.

1.4.10. Filed and granted patents

Name Patent

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1.4.11. Grants

Funding agency Title of project Principal investigator Fonds zur Förderung Doktoratskolleg Molecular, cellular and clinical Heimo Breiteneder der wissenschaftl. Allergology, MCCA Forschung, DK W 1248-B13 Fonds zur Förderung Recombinant allergen derivatives and Heimo Breiteneder Wissenschaftlicher adjuvants to direct dendritic cells. Forschung (FWF) Nr. # 08 in SFB F46 APF04608FW European Community Biomedical engineering for cancer and brain Heimo Breiteneder (FP7-PEOPLE-2010- disease diagnosis and therapy development. ITN 264417-EngCaBra) FA648A0803 Fonds zur Förderung Structure function relationship of food Karin Hoffmann- der wissenschaftl. allergens. Sommergruber Forschung SFB F46 APF04603FW Fonds zur Förderung Doktoratskolleg Molecular, cellular and clinical Karin Hoffmann- der wissenschaftl. Allergology, MCCA Sommergruber Forschung, DK W 1248-B13 Fonds zur Förderung Identification of conformational Christian Radauer Wissenschaftlicher immunoglobulin E epitopes of the major birch Forschung (FWF) pollen allergen, Bet v 1: their cross-reactivities Nr. P 22559-B11 and clinical relevance in the birch pollen-plant APP22559FW food syndrome. Bundesministerium für TCM and Age Related Diseases. Yan Ma Gesundheit, Familie und Jugend (BMGFJ) / Bundesministerium für Wissenschaft und Forschung (BMWF) FA648A0901 Bundesministerium für Prevention and early intervention of chronic Yan Ma Gesundheit, Familie diseases by TCM: Evaluation of und Jugend (BMGFJ) / immunomodulatory, anti-inflammatory and Bundesministerium für neuroprotective effects. Wissenschaft und Forschung (BMWF) FA648A0903 Medizinische Universitätslehrgang Grundlagen und Praxis Yan Ma Universität Wien. der TCM. LG15017010 Eurasia-Pacific Uninet Joint Workshop on Evicence Based Yan Ma Traditional Chinese Medicine: Education and Training.

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1.4.12. Career Developments a) Habilitations: n = 0

b) Habilitations in progress: n = 0

c) Professorships: n = 0

d) Qualification Agreement: n = 0

1.4.13. Teaching a) Bachelor students: n = 1

Marta Coll Llauradó: Universidad Rovira i Virgili, Tarragona, Spain (1.2.-30.6.2014)

b) Diploma, MDiploma and Master students: n = 7

Duan Heying: Master Thesis: Comparison of Eastern and Western Medical Strategies for Prevention of Obesity Prevalence and its Related Diseases. (August 2013 – in Progress).

Feder Astrid: Master Thesis: Efficiency of Acupuncture as a Perioperative Pain Therapy after Total Knee Replacement - A prospective randomized controlled study. (March 2013- in Progress).

Huang Wenyu: Master Thesis: Garnoderma Lucidum for Prevention and Treatment of Pollen-induced Allergic Rhinitis. (October 2013 – November 21, 2014).

Hofstetter Gerlinde: Master thesis: Development of an immunoassay for the detection of Bet v 1-related allergens in plant foods. University of Applied Sciences, Vienna. (November 2012 – 22.09.2014).

Mao Xinjun: Master Thesis: The clinical effect of sham acupuncture for analgesia of total knee replacement in the perioperative period. (October 2013- in Progress)

Spiller Alexandra: Diploma thesis: “Impact of food matrices on allergenic properties of food allergens” (April 2013-10.11.2014).

Wang Xiaoxia: Master Thesis: Prävention und Therapie von koronaren Herzkrankheiten mit Traditionelle Chinesische Medizin. (August 2013 – in Progress).

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Performance Report 2014 – Division 4 Medical Biotechnology c) PhD, MDSci, MD students: n = 10

Ashjaei Kazem: PhD thesis. Influence of allergens on human dendritic and basophil cells (April 2010 – in progress).

Dubiela Pawel: PhD thesis. Food Allergens: Their recombinant production and physicochemical characterization (1st Oct. 2013 – in progress).

Gepp Barbara: PhD thesis. Identification of conformational immunoglobulin E epitopes of the major birch pollen allergen, Bet v 1: their cross-reactivities and clinical relevance in the birch pollen-plant food syndrome (Oct. 2010 – in progress).

Guhsl Eva: Cross-reactive allergens and antibody responses in the birch pollen-plant food syndrome (October 2010 – 16.07.2014).

He Shan: PhD Thesis thesis: Anti-inflammatory effects of the Chinese herbal medicine Sini Tang and Ginseng (Panax quinquefolius) saponins. (N094), (April 2013 – in progress).

Humeniuk Piotr: Food Allergen detection and interaction with the human immune system (October 2014 - in progress).

Kalic Tanja: Characterization of reactions of epithelial cells responsible for high allergenicity of Gad m 1, the major allergen from Atlantic cod (2014 – in progress).

Palladino Chiara: PhD thesis: Biological and allergenic activities of peanut allergens (Oct. 2013 – in progress).

Pucciarelli Daniela: PhD thesis. Melanoma cell detection and identification in biopsies by IR spectroscopy (July 2011 – in progress).

Tscheppe Angelika: “Expression of Ara h 2 wildtype and hypoallergenic mutants in insect and plant cells” (October 2014 – in progress)

1.4.14. Exams a) Oral examinations n = 46

Hoffmann-Sommergruber Karin: N=5 (NM Allergien und Intolerantzen) n = 20

Ma Yan n = 26

104

Performance Report 2014 – Division 4 Medical Biotechnology b) Diploma and Thesis-Examinations: n = 4

Bublin Merima: n = 1 Radauer Christian: n = 1 Ma Yan: n = 2

c) Exam supervising: n = 2

Hoffmann-Sommergruber Karin: Prüfungsaufsicht: FIP 1 (2 Durchgänge, 20 2. 2014). Radauer Christian: SIP2, 28.04.2014

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1.4.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2014 Breiteneder Heimo 2.00 0.11 861007 MCCA Journal Club Breiteneder Heimo 2.00 0.67 881004 Immunobiology and Vascular Diseases Breiteneder Heimo 2.00 2.00 514057 Dissertanten- und Diplomandenseminar: Anleitung zu Wissenschaftlichen Arbeiten Breiteneder Heimo 1.00 1.00 514073 Neueste molekularbiologische Techniken - (Privatissimum) Bublin Merima 2.00 1.00 514074 Nahrungsmittelallergien und -Intoleranzen Hoffmann- Sommergruber Karin 2.00 0.11 861007 MCCA Journal Club Hoffmann- Sommergruber Karin 3.00 0.21 896016 Basics in Gender Medizin 2 Hoffmann- Sommergruber Karin 2.00 1.00 514074 Nahrungsmittelallergien und -Intoleranzen Ma Yan 2.24 0.50 890.081 Schmerzdiagnostik und invasive Techniken Ma Yan 0.67 0.67 891.120 Akupunktur-Behandlung und Moxibustion Ma Yan 2.67 2.67 891.122 Klinische Observation und Praktikum in Österreich Ma Yan 0.67 0.67 891.113 Einführung in die Medizinische chinesische Fachsprache und Kultur (3) Ma Yan 0.67 0.30 891.121 Experimentelle Akupunktur Sum 10.91

WS 2014/15 Breiteneder Heimo 2.00 0.60 502362 Nahrungsmittelallergie Breiteneder Heimo 2.00 2.00 514057 Dissertanten- und Diplomandenseminar Breiteneder Heimo 1.00 1.00 514073 Anleitung zum wissenschaftlichen Arbeiten Breiteneder Heimo 2.00 2.00 648007 Journal Club and Progress Report Breiteneder Heimo 2.00 0.44 861006 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Breiteneder Heimo 2.00 0.13 861007 MCCA Journal Club MCCA Lecture, Thesis Seminar and Basic Course Series on Recombinant Allergens & Breiteneder Heimo 2.00 2.00 861029 Structural Biology Bublin Merima 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Hoffmann- Sommergruber Karin 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Hoffmann- Karin 2.00 0.22 861006 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens

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Sommergruber Hoffmann- Sommergruber Karin 2.00 0.13 861007 MCCA Journal Club Hoffmann- MCCA Lecture, Thesis Seminar and Basic Course Series on Recombinant Allergens & Sommergruber Karin 2.00 2.00 861029 Structural Biology Hoffmann- Sommergruber Karin 2.00 1.00 881001 Infectious Diseases and Vaccines Hoffmann- Sommergruber Karin 2.00 2.00 648009 Anleitungen zu wiss. Arbeiten Ma Yan 4.00 2.50 648004 Einführung in die Traditionelle Chinesische Medizin: Theorie und Praxis (II) Ma Yan 1.00 1.00 800000 Senior-Mentoring Humanmedizin Ma Yan 2.17 0.54 890048 Lebensqualität, Qualitätsmanagement, Management, Wissenschaftliches Ma Yan 0.54 0.54 891109 Einführung in die medizinische chinesische Fachsprache und Kultur (4) Ma Yan 0.54 0.54 891110 Chirurgie in der TCM Ma Yan 1.34 1.34 891114 Innere Medizin in der TCM Ma Yan 0.54 0.54 891117 Orthopädie in der TCM Ma Yan 2.00 1.75 891120 Klinische Observation und Praktikum in Österreich Radauer Christian 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Radauer Christian 2.00 1.00 881000 Biological Therapeutics Sum 24.60 Total sum SS+WS 35.51

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1.5. Division for Experimental Allergology Head: Barbara Bohle, Professor

1. Publications9 IF Number Top/Std/Subst Bohle Barbara 19.757 9 6Top, 2 St. Beatrice Jahn-Schmid 1.905 2 2Top, xx St. Division-Sum 19.757 9

Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

3. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Bohle Barbara 5 Beatrice Jahn-Schmid 1 2 Claudia Kitzmüller 2 Sum 2 1 7

4. Teaching SS* WS* total W+S oral Exams Bohle Barbara 11,13 9.05 20.18 6 Jahn-Schmid Beatrice 2.11 5.88 7.99 Kitzmüller Claudia 0.95 3.6 4.55 Sum 14.19 18.53 32.72 6

9 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 109

Performance Report 2014 – Division 6 Experimental Allergology

1.5.1. Publications a) Peer-reviewed original articles: n=8

Nr. Article IF Class pro-rata IF 1. Deifl, S., C. Zwicker, E. Vejvar, C. Kitzmüller, G. 3.534 TOP 3.534 Gadermaier, B. Nagl, S. Vrtala, P. Briza, G.J. Zlabinger, B. Jahn-Schmid, F. Ferreira and B. Bohle. Glutathione-S- transferase: a minor allergen in birch pollen due to limited release from hydrated pollen. PLoS One, 2:9. e109075. doi: 10.1371/journal.pone.0109075, 2014 2. Jutel M., N.G. Papadopoulos, H. Gronlund, H.J. Hoffman, B. 5.995 TOP 1.199 Bohle, P. Hellings, G.J. Braunsthal, A. Muraro, P. Schmid- Grendelmeier, T. Zuberbier, and I. Agache. Recommendations for the allergy management in the primary care. Allergy, 69:708, doi: 10.1111/all.12382. 2014 3. Ackaert C., S. Kofler, J. Horejs-Hoeck, N. Zulehner, C. Asam, 3.534 TOP 0.706 S. von Grafenstein, J.E. Fuchs, P. Briza, K.R. Liedl, B. Bohle, F. Ferreira, H. Brandstetter, G.J. Oostingh, and A. Duschl. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101. PlosOne; 9:e104520. doi: 10.1371/journal.pone.0104520. 2014 4. Maier, E., D. Werner, A. Duschl, B. Bohle, and J. Horejs- 5.362 TOP 1.072 Hoeck. Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κ B-dependent way. J Immunol.;193:645-54. doi: 10.4049/jimmunol.1301836, 2014 5. Asam, C., A. Batista-Amorim, A. Moraes, V. De Paula, F. 4.324 Std. 0.864 Almeida, L. Aglas, C. Kitzmuller, B. Bohle, C. Ebner, F. Ferreira, M. Wallner, and A. Valente. Bet v 1 – a Trojan horse for small ligands boosting allergic sensitization? Clin Exp Allergy, doi: 10.1111/all.12501,2014 6. Pichler, U., M. Hauser, H. Hofer, M. Himly, E. Hoflehner, M. 4.324 Std. 0.864 Steiner, S. Mutschlechner, K. Hufnagl, C. Ebner, A. Mari, P. Briza, B. Bohle, U. Wiedermann, F. Ferreira, and M. Wallner. Allergen-hybrids - next generation vaccines for Fagales pollen immunotherapy. Clin Exp Allergy, 44:438, doi: 10.1111/cea.12250, 2014 7. Roulias, A.,U. Pichler, M. Hauser, M. Himly, H. Hofer, P. 5.995 TOP 1.199 Lackner, C. Ebner, P. Briza, B. Bohle, M. Egger, M. Wallner, and F. Ferreira. Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis, Allergy, 69:208, doi: 10.1111/all.12306. 2014 8. Deifl, S., C. Kitzmüller, P. Steinberger, M. Himly, B. Jahn- 5.995 TOP 5.995 Schmid, G.F. Fischer, G. J. Zlabinger, B. Bohle. Differential activation of dendritic cells by toll-like receptors causes diverse differentiation of naïve CD4+ T cells from allergic patients. Allergy. 2014;69:1602-9. doi: 10.1111/all.12501. Epub 2014 Oct 3. sum 15.433

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b) Invited Articles & Reviews with IF: n = 1

Nr. Article IF Class pro-rata IF 1. B. BohleImmune mechanisms of SCIT and SLIT: facing 4.324 Std. 4.324 possibledifferences? Clin Exp Allergy. 2014 Mar;44(3):304-6. doi: 10.1111/cea.12263 sum 4.324

c) Invited Articles & Reviews without IF: n = 0

d) Book contributions: n = 0

e) Abstracts, printed in periodicals: n = 0

f) Abstracts, in congress proceedings or abstract books: n = 9

1. Claudia Kitzmüller, Martina Schuschnig, Barbara Bohle. Innate responses and antigen-presenting capacity of oral epithelial cells. 12th EAACI Immunology Winter School, Poiana Brasov, Romania, 30. Jänner – 2. Februar 2014, Poster

2. Claudia Kitzmüller, Martina Schuschnig, Barbara Bohle. Innate responses and antigen-presenting capacity of oral epithelial cells. 13th International Symposium on Dendritic Cells, Tours, Frankreich, 14. – 18. September 2014, Poster

3. Claudia Kitzmüller, Martina Schuschnig, Barbara Bohle. Innate responses and antigen-presenting capacity of oral epithelial cells. ÖGAI Jahrestagung 2014, Salzburg, Austria, 6. – 8. November 2014, oral presentation

4. Werner Dagmar, Zulehner Nora, Nagl Birgit, Zlabinger J. Gerhard and Bohle Barbara. Identification and characterization of natural adjuvants in birch pollen ÖGAI Annual Meeting 6.-8. November 2014, Salzburg, Austria, Poster

5. Werner Dagmar, Zulehner Nora, Nagl Birgit, Zlabinger J. Gerhard and Bohle Barbara. Identification and characterization of natural adjuvants in birch pollen IAI PhD Retreat 30. November – 03. Dezember 2014, Obergurgel, Austria, Poster

6. Michele M Rauber, Christian Möbs , Brinda Subbarayal, Wolfgang Pfützner, Barbara Bohle. Allergen-specific immunotherapy with glutaraldehyde-modified birch pollen extract results in differential induction of allergen-specific blocking IgG4 antibodies. Deutscher Allergiekongress (DAK) 2014, Wiesbaden, Deutschland.

7. Michelle Rauber, Dagmar Werner, Christian Möbs, Wolfgang Pfützner, Barbara Bohle. Glutaraldehyde-modified birch pollen allergoid reveals high stability to endolysosomal degradation by dendritic cells. EAACI Winterschool, Februar 2014, Poiana Brasov, Romania, Poster

8. Brinda Subbarayal, Dirk Schiller, Christian Möbs, Wolfgang Pfützner, Beatrice Jahn- Schmid, Stefan Vieths, Barbara Bohle. Diversity of allergen-specific IgG4 responses

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during birch pollen immunotherapy. CIA meeting September 2014, Petersberg, Deutschland oral presentation 9. Dries Van Hemelen, Vera Mahler, Gottfried Fischer, Ingrid Fae, Victoria Reichl-Leb, Winfried Pickl, Marek Jutel, Sylwia Smolinska, Christof Ebner, Barbara Bohle, Beatrice Jahn-Schmid 30th Symposium of the Collegium Internationale Allergologicum entitled Allergies: Current challenges and solutions from 13-18 September 2014 in Petersberg, Germany, Poster

g) Teaching Scripts and Books: n = 0

h) Articles in Medical Journals: n = 0

i) Public activity: n = 5

Barbara Bohle:

Train the trainers an der MUW Vortrag: "Birch pollen-related food allergy", 14-01-2014

Podiumsdiskussion Öffentlichkeitsarbeit MUW Thema: Allergien, 19-02-2014

Podiumsdiskussion Öffentlichkeitsarbeit MUW Thema: Pollenallergie, „Was Pollen mit Nahrungsmitteln zu tun haben“, 08-04-2014

Radio Interview für Ö1 DIMENSIONEN, Thema: Diagnostik und Therapie von Allergien,12-09-2014

Claudia Kitzmüller:

Lange Nacht der Forschung, Nahrungsmittelallergie, eine harte Nuss zu knacken, 04-04-2014

1.5.2. Research Awards: n = 0

1.5.3. Invited lectures: n = 8

Barbara Bohle:

20-01-2014, Department of Pathology and Diagnostics, Division of General Pathology, University of Verona, Faculty of Medicine, Verona, Italy: „Apples can drive birch pollen- allergic patients nuts“

28-01-2014 Institut für Genetik, Medizinische Universität Wien: „Apples can drive birch pollen – allergic patients nuts!”

15-05-2014, International Forum „Clinical Immunology and Allergology – Interdisciplinary problems“, Kazan, Russia: „Birch pollen-related food allergy“ in Kazan

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07-06-2014, Annual EAACI Congress, Copenhagen, Denmark: “Biomarkers of the treatment response”.

17-09-2014, 14th Paul Ehrlich Seminar, Bad Nauheim, Germany: "Allergen Products for Diagnosis and Therapy: Regulation and Science".

05-12-2014, The ABC in Immunology, Lissabon, Portugal: “Immunoregulation in asthma: biomakers in response to immunotherapy?”.

Beatrice Jahn-Schmid:

04-04-2014, 3rd International Ragweed Conference Milano 3.4-4.4. 2014 in Rho (Milano) “Weed pollen allergy in austria: cross- and co-sensitization against ragweed and mugwort pollen allergy”

04-04-2014, Round table discussion Ambrosia day, Rho, Milano, Italy: “Ragweed allergy 15 years of prevention. How to interprete the double positivity between mugwort and ragweed”.

1.5.4. Congress organization

Division National congress Intern. Congress, member Name: Name, date Function Name, date Function Bohle Barbara European congress of President of the immunology (ECI)2015 scientific committee

1.5.5. Hosting speakers division member Speaker´s name Affiliation Date

1.5.6. Mobility

Name Program University, Time frame Division In Out Country

1.5.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Bohle Barbara Paul Ehrlich Institut, Langen, D Scientific advisor

1.5.8. Editorial Activities

Name Journal Function Bohle Barbara International Archives of Allergy Editor in chief and Immunology 113

Performance Report 2014 – Division 6 Experimental Allergology

Bohle Barbara Clinical and Experimental Editorial Board Member Allergy Bohle Barbara Immunotherapy Editorial Board Member Beatrice Jahn-Schmid Frontiers in Immunology- Review Editor Immunotherapies and Vaccines

1.5.9. Review Activities

Name Grants/Thesis/Habilitation

1.5.10. Filed and granted patents

Name Patent Barbara Bohle Allergen-Immunmodulator Proteine für die Therapie von IgE- mediierter Allergie

1.5.11. Grants

Funding agency Title of project Principal investigator Christian Doppler Immunmodulation allergischer Erkrankungen. Barbara Bohle Gesellschaft und Biomay FA102A0009 FWF der Inflammation and Immunity. Barbara Bohle Wissenschaftsfonds, T cell responses in Type I allergy. Doktoratskolleg Projektnummer: DK APW01212FW FWF der Therapy of birch pollen- related food allergy. Barbara Bohle Wissenschaftsfonds, Projektnummer: APKLI0096FW FWF der Towards prevention and therapy of allergy, Barbara Bohle Wissenschaftsfonds, the Immunological basis of clinical tolerance SFB to allergens. Projektnummer: F 04610 FW FWF der Molecular, cellular and clinical allergology. Barbara Bohle Wissenschaftsfonds, Projektnummer: DK W 1248-B13 FWF der Molecular, cellular and clinical allergology. Beatrice Jahn-Schmid Wissenschaftsfonds, Doktoratskolleg Projektnummer: DK W 1248-B13

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1.5.12. Career Developments a) Habilitations: n=0

b) Habilitations in progress: n = 0

c) Professorships: n=0

1.5.13. Teaching a) Bachelor students: n =2

Claudia Kitzmüller:

1. Sophie Walter: Bachelor student, August 2013 – April 2014, Basophilenaktivierungstests in Patienten vor und nach Immuntherapie

2. Lisa Ziegler: Bachelor student, Jänner 2014 – Juli 2014, Allergenexpression in Hefe, Aufreiningung rekombinanter Proteine

b) Diploma, MDiploma and Master students: n =1

Böll Simone, ab November 2014 bei Beatrice Jahn-Schmid: Humoral immune response to allergen-specific immunotherapy with allergoids

c) PhD, MDSci, MD students: n = 8

1. Dagmar Kollmann: PhD Thesis: The role of alpha-Gal in allergic reactions to meet.

2. Stephan Deifl: PhD Thesis: Development of allergy vaccines using Toll-like receptor ligands as immunomodulatory component

3. Nora Zulehner: PhD Thesis: Characterization of different phenotypes of allergen- specific Th2 cells

4. Dagmar Beatrice Werner: PhD Thesis: Identification of natural adjuvants in birch pollen

5. Dominika Polak: PhD Thesis: The role of neutrophils in IgE-mediated allergy

6. Nazanin Samadi: PhD Thesis: The role of CD8 T cells in allergy (2013- in progress)

7. Manuel Reithofer: PhD Thesis: Allergen-specific immunomodulation by CD8+ T cells

8. Gabriela Sanchez-Acosta: PhD Thesis: The role of allergen-specific IgG antibodies in allergen-specific T cell responses

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Performance Report 2014 – Division 6 Experimental Allergology d) Practical training:

Rauber Michele: Gastforscherin, 22-10-2013 bis 15-09-2014

Vos Byrthe: Gastforscherin, 13-11-13 bis 30-04-2014

1.5.14. Exams: n = 0 a) Oral examinations: n = 0

b) Diploma and Thesis-Examinations: n = 6

2014-04-10: JANIK Stefan, “Immunological Investigations in Patients with Thymoma and Thymic Carcinoma” diploma thesis exam

2014-04-10: BEKOS Christine, “Immunological Investigations in Patients with Myasthenia Gravis” diploma thesis exam

2014-05-27: GEROLDINGER-SIMIC Marija, “birch pollen-related food allergies: clinical, epidemiological and immunological aspects”, PhD thesis exam

2014-06-30: SCHREINER Stefan, "Retrospektive Querschnittsanalyse zur Diagnostik v Überempfindlichkeitsreaktionen auf Röntgenkontrastmittel nach Zwischenfall bei Kontrastmittelaplikation", diploma thesis exam

2014-10-06: SUBBARAYAL Brinda, “Characterization of Allergen-Specific Antibodies induced by Specific Immunotherapy, PhD thesis exam

2014-12-09: MITTERBAUER Andreas, “Tissue-specific auto-reactive CD4CD28null cells in explanted COPD lungs”, diploma thesis exam

c) Exam supervising: n=1

Jahn-Schmid Beatrice: SIP 2, Z-SIP 2, am 26-06-2014

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1.5.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2014 Bohle Barbara 4.00 2.00 648000 Anleitung zum wissenschaftlichen Arbeiten Bohle Barbara 2.00 2.00 648035 Journal Club und Progress Report Bohle Barbara 2.00 2.00 648036 Dissertantenseminar Ziele und Methoden der Allergologie Bohle Barbara 1.00 0.05 809061 MS: Methoden der Allergologie Bohle Barbara 2.00 0.20 860007 Special Course: Scientific Presentation Bohle Barbara 2.00 2.00 860101 Special Course: Cellular allergology Bohle Barbara 2.00 0.17 860201 IAI-Journal Club Bohle Barbara 2.00 0.25 860220 Basisvorlesung Immunologie Bohle Barbara 2.00 0.11 861007 MCCA Journal Club MCCA Lecture, Thesis Seminar and Basic Course Series on Allergic Rhinoconjunctivitis and Bohle Barbara 2.00 0.20 861045 Asthma Bohle Barbara 2.00 0.15 901929 IAI-Basic Seminars Bohle Barbara 2.00 2.00 902211 Dissertantenseminar: Ziele und Methoden der Allergologie Jahn-Schmid Beatrice 2.00 0.11 861007 MCCA Journal Club Jahn-Schmid Beatrice 4.00 2.00 648000 Anleitung zum wissenschaftlichen Arbeiten Kitzmüller Claudia 1.00 0.95 809061 MS: Methoden der Allergologie Sum 14.19

WS 2014/15 Bohle Barbara 2.00 1.00 648000 Journal Club und Progress Report Bohle Barbara 2.00 1.00 648006 Dissertantenseminar Ziele und Methoden der Allergologie Bohle Barbara 4.00 2.00 648100 Anleitung zum wissenschaftlichen Arbeiten Bohle Barbara 2.00 0.18 860008 Special Course: Scientific Presentation Bohle Barbara 2.00 0.22 861006 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Bohle Barbara 2.00 0.13 861007 MCCA Journal Club Bohle Barbara 2.00 0.22 861008 MCCA Lecture, Seminar and Course Series on Allergic Priming and Effector Phase Bohle Barbara 2.00 0.13 901929 IAI-Basic Seminars Bohle Barbara 2.00 2.00 902211 Dissertantenseminar: Ziele und Methoden der Allergologie Bohle Barbara 2.00 0.17 902241 IAI-Journal Club Bohle Barbara 2.00 2.00 902564 Journal Club und Progress Report Jahn-Schmid Beatrice 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

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Jahn-Schmid Beatrice 2.00 0.13 861007 MCCA Journal Club Jahn-Schmid Beatrice 2.00 0.22 861008 MCCA Lecture, Seminar and Course Series on Allergic Priming and Effector Phase Jahn-Schmid Beatrice 2.00 1.00 648000 Journal Club und Progress Report Jahn-Schmid Beatrice 2.00 1.00 648006 Dissertantenseminar Ziele und Methoden der Allergologie Jahn-Schmid Beatrice 4.00 2.00 648100 Anleitung zum wissenschaftlichen Arbeiten Jahn-Schmid Beatrice 1.00 1.00 902542 Grundlagen der Allergologie Kitzmüller Claudia 1.13 1.60 801001 BL 1 - Gesunde und kranke Menschen Kitzmüller Claudia 2.00 2.00 860023 TS B cells and antibodies Sum 18.53 Total sum SS+WS 32.72