2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
Heartland Angels, Gopher https://www.sec.gov/Archives/edgar/dat Angels, Perkins Coie, via the a/1616251/000161625114000001/xslFor Advanced Cooling Therapy Chicago Chicago IL Series A Developer of cooling therapy technologies. 8/14/2014 1.08 TWB Investment Partnership Device mDX01/primary_doc.xml 0.00 1.08 0.00
Bill Gates, Patrick Ryan, David http://www.prnewswire.com/news‐ Deveoper of gene reguluation therapies that Walt, Boon Hwee Koh, Craig releases/aurasense‐therapeutics‐ control the delivery of genetic material into Mundie, Rathmann Family completes‐136‐million‐series‐c‐equity‐ AuraSense Therapeutics Skokie Chicago IL Series C cells. 6/17/2014 13.60 Foundation Biotech investment‐263481661.html 13.60 0.00 0.00 Manufacturer of medicinal drugs. The https://www.sec.gov/Archives/edgar/dat company provides medical products to treat Undisclosed Venture a/1620843/000162084314000002/xslFor Cresco Labs Chicago Chicago IL Angel diseases using marijuana. 10/6/2014 4.00 Investor(s) Biotech mDX01/primary_doc.xml 4.00 0.00 0.00 Develops, manufactures and sells an integrated family of cost‐effective products for http://www.sec.gov/Archives/edgar/data the detection, diagnosis and treatment of Undisclosed Venture /75439/000114420414023078/xslFormD CytoCore Chicago Chicago IL Undisclosed cancer. 4/16/2014 1.53 Investor(s) Device X01/primary_doc.xml 0.00 1.53 0.00 http://www.sec.gov/Archives/edgar/data Developer of a microscopic imaging platform Undisclosed Venture /1528694/000152869414000003/xslFor Diagnostic Photonics Chicago Chicago IL Later for intra‐operative use in clinical settings. 6/12/2014 0.30 Investor(s) Device mDX01/primary_doc.xml 0.00 0.30 0.00 Central Illinois Angels, http://www.sec.gov/Archives/edgar/data Developer of a sensor to monitor the condition Cornerstone Angels, JumpStart /1424668/000142466814000001/xslFor Endotronix Woodridge Chicago IL Later of patients with congestive heart failure. 4/29/2014 1.60 Ventures Device mDX01/primary_doc.xml 0.00 1.60 0.00 https://www.fshealth.com/press/first‐ Provider of online healthcare concierge stop‐health‐receives‐2‐2‐million‐in‐ First Stop Health Chicago Chicago IL Angel service. 3/19/2014 2.20 Undisclosed Angel Investor(s) SW/Services additional‐angel‐financing/ 0.00 0.00 2.20
Provider of a platform for physician‐hospital alignment strategies. The company's DocTime Log platform enables hospitals and health systems to align, creatively design and actively manage the return on investment in physician‐ hospital agreements. It offers automated mobile services for the physicians to log hours https://www.sec.gov/Archives/edgar/dat with a robust tracking to approve time logs a/1595748/000159574814000002/xslFor Ludi Chicago Chicago IL Series A and manage monthly activity. 7/29/2014 1.00 The Martin Companies SW/Services mDX01/primary_doc.xml 0.00 0.00 1.00 Developer of a text mining software for the Undisclosed Angel Investor, Medical Search Technologies Chicago Chicago IL Angel healthcare industry. 4/26/2014 1.20 XLerateHealth SW/Services Pictchbook 0.00 0.00 1.20
http://www.fiercebiotech.com/story/nau Developer of psychiatry and neurology Undisclosed Venture rex‐picks‐25m‐get‐its‐depression‐drugs‐ Naurex Evanston Chicago IL Series B treatment. 5/6/2014 25.00 Investor(s) Biotech through‐phii/2014‐05‐06 25.00 0.00 0.00
Cowen Investments, EcoR1 Capital, Goudy Park Capital, Portola Capital Partners, Sabby Capital, Adams Street Partners, Baxter Ventures, Druid BioVentures, Genesys Capital, H. Lundbeck A/S, Latterell Venture Partners, Northwestern University, https://www.sec.gov/Archives/edgar/dat Developer of psychiatry and neurology PathoCapital, Savitr Capital, a/1467762/000146776214000002/xslFor Naurex Evanston Chicago IL Series C treatment. 12/2/2014 80.00 Takeda Ventures Biotech mDX01/primary_doc.xml 80.00 0.00 0.00
http://www.businesswire.com/news/ho me/20141119005210/en/Novaerus‐ Provider of infection prevention products for Polaris Partners and Fidelity Reaches‐Key‐Milestone‐Funding‐Polaris‐ Novaerus Chicago Chicago IL Growth nursing homes. 11/19/2014 10.00 Biosciences Biotech Partners#.VHy62zHF_Qo 10.00 0.00 0.00
Page 1 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
http://www.purdue.edu/newsroom/relea ses/2014/Q1/ontarget‐laboratories‐ Individual Investor, Pension receives‐15‐million‐to‐develop‐optical‐ OnTarget Laboratories Northbrook Chicago IL Corporate Developer of optical imaging technologies. 3/11/2014 15.00 Fund of the Christian Church Device imaging‐technology‐for‐cancer.html 0.00 15.00 0.00
http://bluesky.chicagotribune.com/origin als/chi‐opternative‐online‐eye‐exam‐ Opternative Chicago Chicago IL Seed Provider of online eye‐examination services. 2/25/2014 1.00 Tribeca Venture Partners SW/Services bsi,0,0.story 0.00 0.00 1.00
LionBird and undisclosed Angel http://www.physiq.com/news‐events/pr‐ PhysIQ Naperville Chicago IL Series A Developer of personalized predictive analytics. 7/24/2014 4.60 investors SW/Services introducing‐physiq‐072414/ 0.00 0.00 4.60
Developer of imaging devices for diagnosing cancer. The company's s products include https://www.sec.gov/Archives/edgar/dat nanoarrays that take images of molecular ARCH Venture Partners, a/1598556/000159855614000001/xslFor PixelEXX Systems Chicago Chicago IL Later signals associated with cellular activity. 1/29/2014 0.65 BioGenerator, Prolog Ventures SW/Services mDX01/primary_doc.xml 0.00 0.00 0.65 Provider of supply‐chain and purchasing‐ http://southernalpha.com/procured‐ Procured Chicago Chicago IL A optimization software for hospitals. 3/5/2014 4.00 FCA Venture Partners SW/Services health‐raises‐4‐0m‐series‐fca/ 0.00 0.00 4.00
Developer of software products to automate healthcare data collection and analytics. The company's software services streamline the reporting process and automate the https://www.sec.gov/Archives/edgar/dat identification of root causes behind usage a/1508806/000150880614000007/xslFor SA Ignite Chicago Chicago IL Series B problems. 7/15/2014 5.37 Undisclosed SW/Services mDX01/primary_doc.xml 0.00 0.00 5.37
http://mobihealthnews.com/32819/swip Undisclosed Venture esense‐raises‐1‐7m‐for‐connected‐hand‐ SwipeSense Evanston Chicago IL Series A2 Provider of a portable hand hygiene device. 5/5/2014 1.75 Investor(s) Device hygiene‐dispensers‐in‐hospitals/ 0.00 1.75 0.00 Heritage Group, Foundation Medical Partners, GE Ventures, Provider of clinical integration and data and North Bridge Growth http://valencehealth.com/news/valence‐ Valence Health Chicago Chicago IL Series B management software. 11/19/2014 15.00 Equity SW/Services health‐secures‐additional‐growth‐capital 0.00 0.00 15.00 http://www.sec.gov/Archives/edgar/data Developer of a drug on molecular defects in Illinois Ventures, Level 5 /1572746/000157274614000001/xslFor Vanquish Oncology Champaign Champaign IL Series A specific cancer cells. 4/10/2014 4.39 Partners, University of Illinois Biotech mDX01/primary_doc.xml 4.39 0.00 0.00 https://www.sec.gov/Archives/edgar/dat Developer of regenerative medical products a/1579613/000157961314000003/xslFor Regenerative Medical Solutions Chicago Chicago IL Early Stage VC for diabetes treatment. 11/7/2014 0.38 Undisclosed Biotech mDX01/primary_doc.xml 0.38 0.00 0.00
Developer of Altum, a minimally invasive cure http://www.sec.gov/Archives/edgar/data for lumbar spinal stenosis that maintains the Undisclosed Venture /1508803/000150880314000003/xslFor Innovative Surgical Designs Bloomington Bloomington IN Early natural dynamics of the spine. 6/30/2014 0.25 Investor(s) Device mDX01/primary_doc.xml 0.00 0.25 0.00 Developer of non‐resorbable films which separate adjacent organs from adhering to Sintact Medical Systems Bloomington Bloomington IN Seed each other after surgery. 8/26/2014 0.03 Health Wildcatters Device PitchBook 0.00 0.30 0.00 Provider of quantitative bioanalytical support http://www.sec.gov/Archives/edgar/data for pre‐clinical and Phase I through Phase III /1595728/000117885814000001/xslFor AIT Bioscience Indianapolis Indianapolis IN Early clinical trials. 1/7/2014 1.00 HALO SW/Services mDX01/primary_doc.xml 0.00 0.00 1.00
Developer of a patented algae cultivation technology and efficient production process for high volume production of nutraceutical Indiana Seed Fund II, Angel https://www.insideindianabusiness.com/ Algaeon Indianapolis Indianapolis IN Early and animal / fish feed products. 5/13/2014 2.75 investors Biotech newsitem.asp?ID=65097 2.75 0.00 0.00
Page 2 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
Developer of a patented algae cultivation technology and efficient production process https://www.sec.gov/Archives/edgar/dat for high volume production of nutraceutical Undisclosed Venture a/1560376/000156037614000001/xslFor Algaeon Indianapolis Indianapolis IN Early and animal / fish feed products. 9/16/2014 0.05 Investor(s) Biotech mDX01/primary_doc.xml 0.05 0.00 0.00 http://www.sec.gov/Archives/edgar/data Developer of case/tray systems for orthopedic /1599940/000159994014000001/xslFor Arcamed Indianapolis Indianapolis IN Growth and surgical industries. 2/12/2014 0.50 Heron Capital Device mDX01/primary_doc.xml 0.00 0.50 0.00 http://www.sec.gov/Archives/edgar/data Provider of custom design and manufacturing /1525032/000152503214000002/xslFor Biologics Modular Brownsburg Indianapolis IN Growth facilities for laboratories based on needs. 3/13/2014 0.03 Angel Investors Biotech mDX01/primary_doc.xml 0.03 0.00 0.00
Developer of orphan drugs for mitochondrial http://www.sec.gov/Archives/edgar/data diseases using a proprietary protein Undisclosed Venture /1603367/000160336714000003/xslFor Chondrial Therapeutics Indianapolis Indianapolis IN Early replacement platform. 6/6/2014 0.10 Investor(s) Biotech mDX01/primary_doc.xml 0.10 0.00 0.00
Developer of orphan drugs for mitochondrial http://www.sec.gov/Archives/edgar/data diseases using a proprietary protein Undisclosed Venture /1603367/000160336714000002/xslFor Chondrial Therapeutics Indianapolis Indianapolis IN Early replacement platform. 3/28/2014 1.00 Investor(s) Biotech mDX01/primary_doc.xml 1.00 0.00 0.00 http://www.sec.gov/Archives/edgar/data /1618426/000161842614000001/xslFor ClariCare Indianapolis Indianapolis IN Early Software for managing dental practices. 9/2/2014 0.20 Angel Investors SW/Services mDX01/primary_doc.xml 0.00 0.00 0.20 http://www.sec.gov/Archives/edgar/data Developer of medical software for hospitals Indiana Seed Fund II, Angel /1570973/000157097314000001/xslFor Diagnotes Indianapolis Indianapolis IN Series A and physician practices. 12/10/2014 0.20 investors SW/Services mDX01/primary_doc.xml 0.00 0.00 0.20 Provider of an online service platform offering cloud‐based customer relationship http://www.sec.gov/Archives/edgar/data management solutions for medical Undisclosed Venture /1132442/000113244214000002/xslFor hc1.com Indianapolis Indianapolis IN Later laboratories. 6/3/2014 1.05 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 1.05
Provider of automated data analysis, data management and data integration services to http://www.ibj.com/lab‐software‐firm‐ the clinical diagnostics reference laboratory raises‐85m‐names‐new‐ Indigo BioSystems Indianapolis Indianapolis IN Undisclosed and life sciences industry. 5/16/2014 8.50 Bootstrap Venture Fund SW/Services ceo/PARAMS/article/48042 0.00 0.00 8.50 http://www.sec.gov/Archives/edgar/data /1514859/000117885814000006/xslFor Marda Medical Indianapolis Indianapolis IN Early Medical device design and development. 7/7/2014 0.30 Angel Investors Device mDX01/primary_doc.xml 0.00 0.30 0.00 http://www.sec.gov/Archives/edgar/data /1628772/000162877214000001/xslFor MB2 Indianapolis Indianapolis IN Early Developer of obesity/diabetes therapeutics 12/24/2014 1.50 Angel Investors Biotech mDX01/primary_doc.xml 1.50 0.00 0.00 http://www.sec.gov/Archives/edgar/data Nanovis uses nanotechnology to enhance the /1464933/000146493314000001/xslFor Nanovis Indianapolis Indianapolis IN Later performance of its surgical implants. 8/5/2014 0.40 Angel Investors Device mDX01/primary_doc.xml 0.00 0.40 0.00 http://www.sec.gov/Archives/edgar/data /1336360/000133636014000001/xslFor SonarMed Carmel Indianapolis IN Series A Developer of endotracheal tubes. 5/5/2014 2.62 Baylor Angel Network Device mDX01/primary_doc.xml 0.00 2.62 0.00
Provider of internet‐based services that allow http://www.sec.gov/Archives/edgar/data for personal assistance, emergency response, Elevate Ventures / Angel /1498738/000149873814000005/xslFor VoCare Indianapolis Indianapolis IN Early and monitoring for elderly patients. 5/16/2014 5.00 Investors SW/Services mDX01/primary_doc.xml 0.00 0.00 5.00 Provider of tech‐enabled dispensing to deliver http://www.sec.gov/Archives/edgar/data pharmacy services at the point of patient care /1495014/000149501414000002/xslFor Wellfount Indianapolis Indianapolis IN Later inside a facility. 4/3/2014 15.00 Deerfield Management SW/Services mDX01/primary_doc.xml 0.00 0.00 15.00 Provider of tech‐enabled dispensing to deliver http://www.sec.gov/Archives/edgar/data pharmacy services at the point of patient care Arboretum Ventures / Elevate /1495014/000090655514000001/xslFor Wellfount Indianapolis Indianapolis IN Later inside a facility. 2/25/2014 1.00 Ventures SW/Services mDX01/primary_doc.xml 0.00 0.00 1.00 Provider of tech‐enabled dispensing to deliver http://www.sec.gov/Archives/edgar/data pharmacy services at the point of patient care Arboretum Ventures / Elevate /1495014/000149501414000001/xslFor Wellfount Indianapolis Indianapolis IN Later inside a facility. 1/14/2014 1.00 Ventures SW/Services mDX01/primary_doc.xml 0.00 0.00 1.00
Page 3 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
Developer of next generation orthopaedic biomaterials that combine hyaluronic acid and ultra high molecular weight polyethylene for Undisclosed Venture http://www.insideindianabusiness.com/n BioPoly Ft. Wayne Ft. Wayne IN Mid‐stage support of anatomical loads. 2/13/2014 5.00 Investor(s) Device ewsitem.asp?id=63663 0.00 5.00 0.00 http://www.sec.gov/Archives/edgar/data Developer of medical devices for scoliosis and /1425450/000142545014000002/xslFor Orthopediatrics Warsaw Ft. Wayne IN Later sports medicine markets. 6/3/2014 39.00 Squadron Capital Device mDX01/primary_doc.xml 0.00 39.00 0.00
Provider of software services that manage supply chain optimization within hospitals, http://www.sec.gov/Archives/edgar/data from manufacturer to distribution to central Undisclosed Venture /1524981/000152498114000001/xslFor Solstice Medical Warsaw Ft. Wayne IN Growth supply to OR to procedure to billing. 3/6/2014 1.12 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 1.12
http://www.purdue.edu/newsroom/relea Developer of new materials to improve ses/2014/Q1/purdue‐research‐ chromatography, specifically protein analysis foundations‐emerging‐innovations‐fund‐ bioVidria West Lafayette West Lafayette IN Early efforts in pharmaceuticals and agriculture. 2/12/2014 0.08 Emerging Innovations Fund Biotech invests‐150,000‐in‐two‐startups.html 0.08 0.00 0.00 http://purdueresearchpark.com/news/on Developer of small molecules that target target‐laboratories‐receives‐15‐million‐ specific pathological cells, when conjugated Pension Fund of the Christian develop‐optical‐imaging‐technology‐ On Target Laboratories West Lafayette West Lafayette IN Mid‐stage with fluorescent dyes. 3/11/2014 15.00 Church / Individual Biotech cancer 15.00 0.00 0.00
http://www.purdue.edu/newsroom/relea Developer of a medical device that is designed ses/2014/Q2/speechvive‐completes‐ to elicit naturally improved speech clarity and funding‐to‐move‐speech‐aid‐for‐ SpeechVive West Lafayette West Lafayette IN Series A volume for patients with Parkinson's Disease. 4/2/2014 0.70 Ambassador Enterprises Device parkinsons‐patients‐to‐the‐public.html 0.00 0.07 0.00
http://www.purdue.edu/newsroom/relea Provider of boutique equipment ses/2014/Q1/purdue‐research‐ manufacturing that supports basic and foundations‐emerging‐innovations‐fund‐ Telos Discovery Systems West Lafayette West Lafayette IN Early discovery medical research. 2/12/2014 0.08 Emerging Innovations Fund Device invests‐150,000‐in‐two‐startups.html 0.00 0.08 0.00 http://www.summitpartners.com/news/s Manufacturer of custom, synthetic DNA, RNA ummit‐partners‐makes‐growth‐equity‐ Integrated DNA Technologies Coralville Iowa City IA Undisclosed oligonucleotides and genes. 3/19/2014 Undisclosed Summit Partners Biotech investment‐in‐idt Undisclosed 0.00 0.00 http://www.bizjournals.com/kansascity/n Provider of information technology solutions Grayhawk Capital, Kansas ews/2014/03/06/overland‐park‐health‐it‐ Health Outcomes Sciences Overland Park Kansas City KS First to the healthcare industry. 3/5/2014 5.00 Bioscience Authority SW/Services startup‐closes.html 0.00 0.00 5.00 Developer of novel therapeutics and drug delivery technologies. The company is https://www.sec.gov/Archives/edgar/dat developing peptide drugs focused on the a/1492422/000149242214000003/xslFor Apellis Pharmaceuticals Crestwood Louisville KY Series C immunology space. 8/21/2014 17.80 Undisclosed BioTech mDX01/primary_doc.xml 17.80 0.00 0.00
http://medcitynews.com/2014/12/immu notherapy‐player‐apellis‐pharmaceuticals‐ raises‐ 33m/?utm_source=MedCity+News+Subsc Developer of novel therapeutics and drug ribers&utm_campaign=ab164088d5‐ delivery technologies. The company is Morningside Ventures, AJU IB RSS_EMAIL_CAMPAIGN&utm_medium=e developing peptide drugs focused on the Investment Co. and Epidarex mail&utm_term=0_c05cce483a‐ Apellis Pharmaceuticals Crestwood Louisville KY Series C immunology space. 12/2/2014 33.00 Ventures BioTech ab164088d5‐67860577 33.00 0.00 0.00
The company provides a wristband device for debilitating neuropathic disorders that increases the sensation of touch, movement TheraBracelet Louisville Louisville KY Bridge and fine motor skills in the hands. 8/15/2014 0.15 Mercury Fund Device Pitchbook 0.00 0.15 0.00
Provider of health management platform which uses data from connected devices and gamified behavior tracking to help people with conditions like pre‐diabetes or pre‐ Personal Medicine Plus Paducah Paducah KY Seed hypertension. 10/7/2014 Undisclosed StartUp Health SW/Services Pitchbook 0.00 0.00 Undisclosed
Page 4 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
http://arbormetrix.com/arbormetrix‐ receives‐additional‐1‐3‐million‐in‐series‐b‐ Provider of clinical performance analytics tools Renaissance Venture Capital financing‐from‐renaissance‐venture‐ ArborMetrix Ann Arbor Detroit/Ann Arbor MI Series B for hospital and specialty‐based care. 2/10/2014 1.30 Fund, Detroit Innovate SW/Services capital‐fund‐and‐detroit‐innovate‐fund/ 0.00 0.00 1.30 Operator of an online healthcare platform for https://www.sec.gov/Archives/edgar/dat patients to identify clinical trials that match Undisclosed Venture a/1612093/000161209314000002/xslFor CureLauncher Bloomfield Hills Detroit/Ann Arbor MI Early Stage their health conditions. 9/12/2014 0.20 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 0.20 Provider of platforms and proprietary https://www.sec.gov/Archives/edgar/dat consumables for cancer research and cancer Undisclosed Venture a/1545264/000154526414000002/xslFor DeNovo Sciences Plymouth Detroit/Ann Arbor MI Series A monitoring. 12/5/2014 2.25 Investor(s) Biotech mDX01/primary_doc.xml 2.25 0.00 0.00 Provider of photoacoustic products and medical imaging technologies; developed a http://www.sec.gov/Archives/edgar/data preclinical scanner using photoacoustic Undisclosed Venture /1603196/000141588914000938/xslFor Endra Ann Arbor Detroit/Ann Arbor MI Second imaging. 3/14/2014 0.29 Investor(s) Device mDX01/primary_doc.xml 0.00 0.29 0.00 Fletcher Spaght Ventures, http://www.sec.gov/Archives/edgar/data Developer and provider of medical histotripsy Hatteras Venture Partners, /1479012/000147901214000001/xslFor HistoSonics Ann Arbor Detroit/Ann Arbor MI A devices. 5/16/2014 14.17 TGap Ventures Device mDX01/primary_doc.xml 0.00 14.17 0.00 Developer of small molecule http://www.sec.gov/Archives/edgar/data immunomodulators for the treatment of Undisclosed Venture /1382268/000156586114000001/xslFor Lycera Ann Arbor Detroit/Ann Arbor MI Convertible Debt patients with autoimmune diseases. 4/4/2014 4.00 Investor(s) Biotech mDX01/primary_doc.xml 4.00 0.00 0.00 Developer of a molecular diagnostics treatment and provider of molecule testing Baird Capital, Pfizer Ventures, http://www.bizjournals.com/milwaukee/ facilities in hospital and clinical reference Venture Investors, Arboretum blog/2014/04/baird‐capital‐invests‐in‐ NeuMoDx Molecular Ann Arbor Detroit/Ann Arbor MI Series B laboratories. 4/1/2014 21.00 Ventures Device michigan‐molecular.html 0.00 21.00 0.00
Capital Community Angels, Biosciences Research and Commercialization Center at Western Michigan University, Michigan Economic The company develops drugs and Development Corporation, ONL manufactures photoceceptor protective management and other ONL Therapeutics Ann Arbor Detroit/Ann Arbor MI Bridge agents to treat retinal disorders. 11/12/2014 1.00 undisclosed investors Biotech Pitchbook 1.00 0.00 0.00
Vivo Capital, Frazier Healthcare Ventures, OrbiMed Advisors, Adams Street Partners, RA Capital Management, Caxton Alternative Management, Hopen Life Science Ventures, Sectoral Asset Management, Janus Capital Management, http://www.crainsdetroit.com/article/20 Developer of nucleic acid therapeutics that Capital Midwest Fund, Apjohn 140422/NEWS/140429956/pronai‐ target DNA to treat patients with cancer and Ventures Fund, Grand Angels, therapeutics‐closes‐on‐largest‐vc‐funding‐ ProNAi Therapeutics Plymouth Detroit/Ann Arbor MI Series D other complex genetic diseases. 4/22/2014 59.50 Amherst Fund Biotech round‐in‐state# 59.50 0.00 0.00 Developer of endovascular catheters to provide an alternative to surgical renal BioStar Ventures, Michigan http://www.xconomy.com/detroit/2013/ denervation for the treatment of Accelerator, Other Venture 05/20/ablative‐solutions‐obtains‐950000‐ Ablative Solutions Kalamazoo SW Michigan MI Series B hypertension. 1/7/2014 9.57 Investor(s) Device new‐funding‐round/ 0.00 9.57 0.00 BioStar Ventures, Michigan https://www.sec.gov/Archives/edgar/dat Developer of psychiatry and neurology Accelerator, Other Venture a/1535723/000153572314000002/xslFor Ablative Solutions Kalamazoo SW Michigan MI Series B treatment. 10/22/2014 14.30 Investor(s) Device mDX01/primary_doc.xml 0.00 14.30 0.00
Provider of small scale clinical trial materials and services, such as sterile product http://www.sec.gov/Archives/edgar/data development and manufacturing, and also Undisclosed Venture /1567440/000156744014000001/xslFor Grand River Aseptic Manufacturing Grand Rapids SW Michigan MI Series C microbiological services. 6/9/2014 4.08 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 4.08
Page 5 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
Developer of healthcare data assimilation, communication, and analytics based decision https://www.sec.gov/Archives/edgar/dat support tools that support the ICU, Operating Social+Capital Partnership, a/1597172/000118143114002726/xslFor Ambient Clinical Analytics Minneapolis Minneapolis MN Seed Room and Emergency Department. 1/15/2014 1.19 Rock Health, Mayo Clinic SW/Services mDX01/primary_doc.xml 0.00 0.00 1.19 http://www.sec.gov/Archives/edgar/data Developer of a normothermia technology for Undisclosed Venture /1474805/000118143114024845/xslFor Augustine Temperature Management Eden Prairie Minneapolis MN Undisclosed warming surgical patients. 6/24/2014 0.96 Investor(s) Device mDX01/primary_doc.xml 0.00 0.96 0.00 BioStar Ventures and https://www.sec.gov/Archives/edgar/dat Med‐tech company currently operating in Undisclosed Venture a/1617867/000161786714000001/xslFor Autonomix Medical Excelsior Minneapolis MN Series A stealth mode. 8/29/2014 3.80 Investor(s) Device mDX01/primary_doc.xml 0.00 3.80 0.00
Wholesale provider of extracts used in dietary supplements, cosmetics, personal care http://mn.gov/deed/images/ATC_Credit_ Betula Extractives Waconia Minneapolis MN Early products, and drug research. 5/15/2014 0.25 Angel Investors Biotech Allocation_List2014.docx 0.25 0.00 0.00
http://www.bizjournals.com/twincities/p Developer of a powder that transforms into Undisclosed Venture rint‐edition/2014/05/02/funding‐digest‐ Bioactive Regenerative Therapeutics Minneapolis Minneapolis MN Undisclosed tissue used in scientific research. 4/14/2014 1.13 Investor(s) Biotech keep‐an‐eye‐on‐tech‐and‐health.html 1.13 0.00 0.00 Provider of a pain management and cartilage http://www.sec.gov/Archives/edgar/data restoration device that uses pulsed Undisclosed Venture /1541017/000154101714000001/xslFor BioMagnetic Sciences Minneapolis Minneapolis MN Undisclosed electromagnetic fields. 3/18/2014 0.27 Investor(s) Device mDX01/primary_doc.xml 0.00 0.27 0.00
Developer of natural beta 1,3/1,6 glucan https://www.sec.gov/Archives/edgar/dat compounds that engage and direct natural Undisclosed Venture a/1624720/000118143114038473/xslFor Biothera Eagan Minneapolis MN Early innate immune system responses. 12/10/2014 1.59 Investor(s) Biotech mDX01/primary_doc.xml 1.59 0.00 0.00 http://mn.gov/deed/images/ATC_Credit_ Cardio Flow Minneapolis Minneapolis MN Early Developer of devices for cardiac disorders. 5/15/2014 0.15 Angel Investors Device Allocation_List2014.docx 0.00 0.15 0.00 http://www.sec.gov/Archives/edgar/data Developer of advanced biologic therapies for a Undisclosed Venture /1603454/000118143114013755/xslFor Celcuity Minneapolis Minneapolis MN Undisclosed range of disorders. 3/21/2014 4.00 Investor(s) Biotech mDX01/primary_doc.xml 4.00 0.00 0.00
Manufacturer and designer of topical http://mn.gov/deed/images/ATC_Credit_ Chitogen Minneapolis Minneapolis MN Early hemostats and related woundcare products. 5/15/2014 0.18 Angel Investors Device Allocation_List2014.docx 0.00 0.18 0.00 https://www.sec.gov/Archives/edgar/dat Manufacturer and designer of topical Undisclosed Venture a/1470264/000147026414000002/xslFor Chitogen Minneapolis Minneapolis MN Early hemostats and related woundcare products. 7/1/2014 1.55 Investor(s) Device mDX01/primary_doc.xml 0.00 1.55 0.00
http://www.fiercemedicaldevices.com/pr ess‐releases/conventus‐orthopaedics‐ raises‐24‐million‐fuel‐growth‐and‐ Developer of implants that stabalize fracture Deerfield Management innovation‐ Conventus Orthopaedics Maple Grove Minneapolis MN Series AA fragments from within the bone. 12/3/2014 24.00 Company, Ally Bridge Group Device 0?utm_medium=nl&utm_source=internal 0.00 24.00 0.00
http://www.fiercemedicaldevices.com/pr ess‐releases/conventus‐orthopaedics‐ Sightline Partners, Spray Fund, raises‐24‐million‐fuel‐growth‐and‐ Developer of implants that stabalize fracture Blue Stem Capital, BioStar innovation‐ Conventus Orthopaedics Maple Grove Minneapolis MN Convertible Debt fragments from within the bone. 4/1/2014 10.00 Ventures, Blue Sky Fund Device 0?utm_medium=nl&utm_source=internal 0.00 10.00 0.00
Developer of the second generation Barostim http://www.marketwatch.com/story/cvrx‐ neo, an implantable system designed to treat Undisclosed Venture secures‐15‐million‐growth‐capital‐facility‐ CVRx Minneapolis Minneapolis MN Convertible Debt hypertension and heart failure. 9/22/2014 15.00 Investor(s) Device from‐silicon‐valley‐bank‐2014‐09‐22 0.00 15.00 0.00
Developer of a system to assist orthopedic http://www.sec.gov/Archives/edgar/data surgeons in the delivery and distal locking of Undisclosed Venture /1450951/000123580214000019/xslFor DGI Medortho Minneapolis Minneapolis MN Convertible Debt long‐bone intramedullary implants. 2/19/2014 0.35 Investor(s) Device mDX01/primary_doc.xml 0.00 0.35 0.00
Developer of RxConnect, a computer/tablet based digital dental prescription generator, http://mn.gov/deed/images/ATC_Credit_ Digital Dental Solutions Minnetonka Minneapolis MN Early transmitter and tracker. 5/15/2014 0.09 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.09
Page 6 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services http://mn.gov/deed/images/ATC_Credit_ DirectAccess Medical Minneapolis Minneapolis MN Early Developer of catheters for dialysis access. 3/30/2014 1.40 Angel Investors Device Allocation_List2014.docx 0.00 1.40 0.00
Developer of custom dental solutions for the http://mn.gov/deed/images/ATC_Credit_ Dreamgard Minneapolis Minneapolis MN Early treatment of nighttime teeth grinding. 2/4/2014 0.48 Angel Investors Device Allocation_List2014.docx 0.00 0.48 0.00 Developer of resorbable and drug loaded https://www.sec.gov/Archives/edgar/dat embolization devices for the treatment of Undisclosed Venture a/1592901/000118143114004686/xslFor EmboMedics Minneapolis Minneapolis MN Series A multiple indications. 2/3/2014 0.86 Investor(s) Device mDX01/primary_doc.xml 0.00 0.86 0.00 Developer of resorbable and drug loaded https://www.sec.gov/Archives/edgar/dat embolization devices for the treatment of Undisclosed Venture a/1592901/000118143114029189/xslFor EmboMedics Minneapolis Minneapolis MN Undisclosed multiple indications. 8/14/2014 0.85 Investor(s) Device mDX01/primary_doc.xml 0.00 0.85 0.00 Developer of resorbable and drug loaded embolization devices for the treatment of http://mn.gov/deed/images/ATC_Credit_ EmboMedics Minneapolis Minneapolis MN Early multiple indications. 3/12/2014 0.05 Angel Investors Device Allocation_List2014.docx 0.00 0.05 0.00 Cloud‐based image processing for exchanging leading‐edge algorithms and analyzing http://mn.gov/deed/images/ATC_Credit_ Flywheel Exchange Minneapolis Minneapolis MN Early research data. 3/11/2014 0.30 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.30 http://tech.mn/news/2014/05/20/genev Developer of a solution to make implantable Undisclosed Venture a‐healthcare‐raises‐1‐8m‐for‐cardiac‐ Geneva Healthcare Minneapolis Minneapolis MN Undisclosed device data available to clinicians and patients. 5/20/2014 1.80 Investor(s) SW/Services device‐data/ 0.00 0.00 1.80 Provider of health insurance services such as health plan troubleshooting, ongoing consultation, analysis of spending across https://www.sec.gov/Archives/edgar/dat health care accounts, and assistance in paying a/1585592/000118143114013523/xslFor Gravie Minneapolis Minneapolis MN Series A bills. 3/20/2014 10.47 Aberdare Ventures SW/Services mDX01/primary_doc.xml 0.00 0.00 10.47 http://www.sec.gov/Archives/edgar/data Developer of implantable devices for the Undisclosed Venture /1472154/000128823014000013/xslFor GT Urological Minneapolis Minneapolis MN Undisclosed treatment of urinary incontinence. 10/1/2014 5.00 Investor(s) Device mDX01/primary_doc.xml 0.00 5.00 0.00
http://www.bizjournals.com/twincities/p rint‐edition/2014/04/18/funding‐ roundup‐tendyne‐holdings‐naiku‐health‐ Healthcare Engagement Solutions Minneapolis Minneapolis MN Angel Developer of mobile healthcare apps. 4/10/2014 0.55 Angel Investors SW/Services care.html 0.00 0.00 0.55 http://www.sec.gov/Archives/edgar/data Provider of remote monitoring technology for Undisclosed Venture /1415696/000118143114016164/xslFor HealthSense Minneapolis Minneapolis MN Convertible Debt the senior care industry. 4/15/2014 2.00 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 2.00 Mansa Capital, Merck Global https://www.sec.gov/Archives/edgar/dat Provider of remote monitoring technology for Health Innovation Fund, a/1415696/000118143114029628/xslFor HealthSense Minneapolis Minneapolis MN Series C the senior care industry. 8/19/2014 7.29 Radius Ventures SW/Services mDX01/primary_doc.xml 0.00 0.00 7.29
http://www.bizjournals.com/twincities/bl Vertex Venture, Advanced og/in_private/2014/04/med‐tech‐startup‐ Technology Ventures, fighting‐lung‐disease‐raises‐ Morgenthaler Ventures, Split 42m.html?utm_source=feedburner&utm Rock Partners, Versant _medium=feed&utm_campaign=Feed%3 Developer of medical devices to treat Ventures, Windham Venture A+bizj_twincities+(Minneapolis+%2F+St.+ Holaira Plymouth Minneapolis MN Series D obstructive lung diseases. 4/3/2014 42.00 Partners Device Paul+Business+Journal) 0.00 42.00 0.00 http://www.sec.gov/Archives/edgar/data Developer of noninvasive reporter gene Undisclosed Venture /1603457/000118143114013782/xslFor Imanis Life Sciences Minneapolis Minneapolis MN Undisclosed imaging products. 3/24/2014 1.00 Investor(s) Biotech mDX01/primary_doc.xml 1.00 0.00 0.00
Developer of medical imaging software solutions designed to deliver quantitative image biomarker algorithms as part of a http://mn.gov/deed/images/ATC_Credit_ Imbio Minneapolis Minneapolis MN Early streamlined Radiology workflow. 3/11/2014 1.90 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 1.90
Page 7 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
OrbiMed, Aperture Venture Partners, GDN Holdings, Johnson & Johnson Development Corporation, Kleiner Perkins Caufield & Developer of a fully implanted Byers, US Venture Partners, http://medcitynews.com/2014/05/inspir neurostimulation system for the treatment of Synergy Life Science Partners, e‐medical‐systems‐raised‐40m‐bring‐fda‐ Inspire Medical Systems Maple Grove Minneapolis MN Series E Obstructive Sleep Apnea. 5/16/2014 40.00 Medtronic, TGap Ventures Device approved‐sleep‐apnea‐implant‐market/ 0.00 40.00 0.00 Developer of medical devices for use in Arthurian Life Sciences and http://www.biospace.com/News/interrad‐ minimally invasive interventional and surgical other Undisclosed Venture medical‐announces‐closing‐7‐5‐ InterRad Medical Plymouth Minneapolis MN Series E procedures. 12/1/2014 7.50 Investor(s) Device million/356413 0.00 7.50 0.00 https://www.sec.gov/Archives/edgar/dat Developer of aortic valvuloplasty balloon for Undisclosed Venture a/1528412/000152841214000001/xslFor InterValve Minnetonka Minneapolis MN Series A treatment of calcific aortic stenosis. 8/14/2014 2.57 Investor(s) Device mDX01/primary_doc.xml 0.00 2.57 0.00
Provider of design and development services for biomedical instrumentation, medical devices, high throughput robotics, and http://mn.gov/deed/images/ATC_Credit_ Laboratory Automation and Biotechnology Minneapolis Minneapolis MN Early graphical interface and related software 1/11/2014 0.08 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.08 Cultivator, processor and distributor of https://www.sec.gov/Archives/edgar/dat medical cannabis, administered by the State of a/1621013/000118143114037869/xslFor Leafline Labs Minneapolis Minneapolis MN Early Minnesota. 12/3/2014 12.40 Angel Investors Biotech mDX01/primary_doc.xml 12.40 0.00 0.00 http://www.sec.gov/Archives/edgar/data Provides hospitals and health systems with Undisclosed Venture /1599415/000159941514000001/xslFor Logicstream Health Minneapolis Minneapolis MN Convertible Debt electronic health record analytics. 3/4/2014 0.15 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 0.15 Provides hospitals and health systems with http://mn.gov/deed/images/ATC_Credit_ Logicstream Health Minneapolis Minneapolis MN Early electronic health record analytics. 5/16/2014 0.24 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.24
Developer of a web‐based system for hospitals http://mn.gov/deed/images/ATC_Credit_ Luminat St. Louis Park Minneapolis MN Early to aid in managing a patient's end‐of‐life care. 3/10/2014 0.15 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.15 http://www.bizjournals.com/twincities/bl og/in_private/2014/12/end‐of‐life‐care‐ Developer of a web‐based system for hospitals startup‐luminat‐raises‐1‐ Luminat St. Louis Park Minneapolis MN Series A to aid in managing a patient's end‐of‐life care. 12/9/2014 2.30 City of Hope SW/Services 5m.html?page=all 0.00 0.00 2.30 Provider of biotechnology product design http://mn.gov/deed/images/ATC_Credit_ Matrix MedTech Minneapolis Minneapolis MN Early services for medical devices. 3/30/2014 0.05 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.05
Provider of a web‐based clinical study management system that is customizable for https://www.sec.gov/Archives/edgar/dat trial management and offers a many a/1613878/000123580214000092/xslFor Mednet Solutions Minnetonka Minneapolis MN Series A capabilities for electronic data capture. 7/14/2014 2.00 Arrowroot Capital SW/Services mDX01/primary_doc.xml 0.00 0.00 2.00
Developer of a software program that allows health care teams to improve workflow in http://mn.gov/deed/images/ATC_Credit_ Mednology Solutions Excelsior Minneapolis MN Early hospitals and urgent care centers. 3/10/2014 0.35 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.35 Manufacturer of instruments for the http://www.sec.gov/Archives/edgar/data treatment of metabolic disorders such as Type Undisclosed Venture /1477042/000147704214000001/xslFor MetaModix Minneapolis Minneapolis MN Undisclosed 2 diabetes and obesity. 4/7/2014 0.15 Investor(s) Device mDX01/primary_doc.xml 0.00 0.15 0.00 http://www.sec.gov/Archives/edgar/data Developer of perfusion decellularization Undisclosed Venture /1527096/000128823014000006/xslFor Miromatrix Medical Eden Prairie Minneapolis MN Undisclosed technology. 5/19/2014 6.14 Investor(s) Biotech mDX01/primary_doc.xml 6.14 0.00 0.00
Developer of a minimally invasive surgical interface platform that monitors ablation Birchview Capital, The Vertical http://www.sec.gov/Archives/edgar/data contours and allows for real‐time MRI ‐guided Group, BDC Capical Healthcare /1625785/000118143114036643/xslFor Monteris Medical Plymouth Minneapolis MN Series B support for clinical decisions. 11/18/2014 16.90 Fund Device mDX01/primary_doc.xml 0.00 16.90 0.00 Medical device startup focusing on organ‐ http://www.sec.gov/Archives/edgar/data specific therapy‐delivery technology for Undisclosed Venture /1602486/000118143114014255/xslFor Nirva Medical Minneapolis Minneapolis MN Convertible Debt various applications. 3/27/2014 0.03 Investor(s) Device mDX01/primary_doc.xml 0.00 0.03 0.00
Page 8 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services Medical device startup focusing on organ‐ specific therapy‐delivery technology for http://mn.gov/deed/images/ATC_Credit_ Nirva Medical Minneapolis Minneapolis MN Early various applications. 5/15/2014 0.18 Angel Investors Device Allocation_List2014.docx 0.00 0.18 0.00
Developer of conductor technology for clinical performance of pacing, cardiac http://mn.gov/deed/images/ATC_Credit_ NuAx (Cardia Access) Eden Prairie Minneapolis MN Early resynchronization and defibrillation therapy. 3/14/2014 0.15 Angel Investors Device Allocation_List2014.docx 0.00 0.15 0.00
Producer of soy peptones used in microbiological media, fermentation nutrient http://mn.gov/deed/images/ATC_Credit_ Nu‐Tek BioSciences Minnetonka Minneapolis MN Early systems, and cell and tissue culture media. 2/1/2014 0.39 Angel Investors Biotech Allocation_List2014.docx 0.39 0.00 0.00
Developer of a device to treat Benign Prostatic Undisclosed Venture http://www.pehub.com/2014/02/vc‐ NxThera Maple Grove Minneapolis MN Series C Hyperplasia. 2/27/2014 25.63 Investor(s) Device backed‐nxthera‐nabs‐series‐c‐funds/ 0.00 25.63 0.00 Provider of a web‐based managed service that allows for better management of anemia in http://mn.gov/deed/images/ATC_Credit_ Patient Readiness Institute Minneapolis Minneapolis MN Angel patients. 3/30/2014 0.16 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.16
Developer of medical devices and surgical http://www.sec.gov/Archives/edgar/data tools that enable children's ear tube Undisclosed Venture /1537953/000118143114004542/xslFor Preceptis Medical Minneapolis Minneapolis MN Series A procedures without general anesthesia. 1/31/2014 4.38 Investor(s) Device mDX01/primary_doc.xml 0.00 4.38 0.00
Developer of mobile healthcare applications Arthur Ventures & Undisclosed Preventice Minneapolis Minneapolis MN Early and remote monitoring technologies. 2/28/2014 20.00 Venture Investor(s) SW/Services PitchBook 0.00 0.00 20.00 http://www.sec.gov/Archives/edgar/data Developer of catheter infection reduction Undisclosed Venture /1543609/000154360914000001/xslFor Pursuit Vascular Minneapolis Minneapolis MN Later technology. 2/18/2014 1.57 Investor(s) Device mDX01/primary_doc.xml 0.00 1.57 0.00 https://www.sec.gov/Archives/edgar/dat Developer of human microbe drugs for the Undisclosed Venture a/1532997/000153299714000002/xslFor Rebiotix (MikrobEX Inc.) Roseville Minneapolis MN Series B treatment of gastrointestinal diseases. 8/4/2014 18.00 Investor(s) Biotech mDX01/primary_doc.xml 18.00 0.00 0.00
Developer of animal models with defined genetic conditions identical to those found in human patients for use in the pharmaceutical http://mn.gov/deed/images/ATC_Credit_ Recombinetics Minneapolis Minneapolis MN Early and medical device industries. 5/19/2014 2.55 Angel Investors Biotech Allocation_List2014.docx 2.55 0.00 0.00
Developer of animal models with defined genetic conditions identical to those found in https://www.sec.gov/Archives/edgar/dat human patients for use in the pharmaceutical Undisclosed Venture a/1543926/000118143114035002/xslFor Recombinetics Minneapolis Minneapolis MN Undisclosed and medical device industries. 10/30/2014 0.54 Investor(s) Biotech mDX01/primary_doc.xml 0.54 0.00 0.00 Developer of a neurostimulation device https://www.sec.gov/Archives/edgar/dat designed to deliver electrical pulses at night to Undisclosed Venture a/1447604/000118143114026416/xslFor Respicardia (Cardiac Concepts) Minnetonka Minneapolis MN Convertible Debt address central sleep apnea. 7/8/2014 2.00 Investor(s) Device mDX01/primary_doc.xml 0.00 2.00 0.00 Developer of a neurostimulation device https://www.sec.gov/Archives/edgar/dat designed to deliver electrical pulses at night to Undisclosed Venture a/1447604/000118143114030374/xslFor Respicardia (Cardiac Concepts) Minnetonka Minneapolis MN Convertible Debt address central sleep apnea. 8/27/2014 5.00 Investor(s) Device mDX01/primary_doc.xml 0.00 5.00 0.00 Developer of a neurostimulation device https://www.sec.gov/Archives/edgar/dat designed to deliver electrical pulses at night to a/1447604/000118143114034876/xslFor Respicardia (Cardiac Concepts) Minnetonka Minneapolis MN Series D address central sleep apnea. 10/28/2014 25.09 Sorin Group Device mDX01/primary_doc.xml 0.00 25.09 0.00 Developer of medical device that addresses Life Sciences Partners, New https://www.sec.gov/Archives/edgar/dat rotator cuff repair via a collagen scaffold Enterprise Associates, Pappas a/1387966/000138796614000001/xslFor Rotation Medical Plymouth Minneapolis MN Series B implant. 7/1/2014 21.72 Ventures Device mDX01/primary_doc.xml 0.00 21.72 0.00 http://www.sec.gov/Archives/edgar/data Developer of a fluid management system that Undisclosed Venture /1446159/000114420414006193/xslFor Skyline Medical Minneapolis Minneapolis MN Undisclosed enhances safety for patients and staff. 2/5/2014 2.00 Investor(s) Device mDX01/primary_doc.xml 0.00 2.00 0.00
http://www.bizjournals.com/twincities/bl Developer of pharmaceutical injection for the Undisclosed Venture og/in_private/2014/06/spinethera‐back‐ SpineThera Minneapolis Minneapolis MN Undisclosed treatment of back pain. 6/5/2014 0.75 Investor(s) Biotech pain‐shot‐raises‐750k.html 0.75 0.00 0.00 Developer of unique platform technology that http://www.sec.gov/Archives/edgar/data uniformly disperses clot‐forming proteins to an Undisclosed Venture /1501385/000150138514000001/xslFor St. Teresa Medical Minneapolis Minneapolis MN Undisclosed injury site. 3/18/2014 1.13 Investor(s) Biotech mDX01/primary_doc.xml 1.13 0.00 0.00
Page 9 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services Developing data‐driven solutions for http://mn.gov/deed/images/ATC_Credit_ Streamline Minneapolis Minneapolis MN Early healthcare. 3/30/2014 0.67 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.67 http://www.sec.gov/Archives/edgar/data Developer of a medical device for the Undisclosed Venture /1557648/000155764814000001/xslFor Tendyne Holdings Minneapolis Minneapolis MN Convertible Debt treatment of mitral regurgitation. 3/7/2014 1.00 Investor(s) Device mDX01/primary_doc.xml 0.00 1.00 0.00 http://www.sec.gov/Archives/edgar/data Developer of a medical device for the Undisclosed Venture /1557648/000155764814000003/xslFor Tendyne Holdings Minneapolis Minneapolis MN Undisclosed treatment of mitral regurgitation. 3/17/2014 25.00 Investor(s) Device mDX01/primary_doc.xml 0.00 25.00 0.00 Manufacturer and supplier of tissue products for cardiac, vascular and other specialty http://mn.gov/deed/images/ATC_Credit_ Tissx Minneapolis Minneapolis MN Eary surgeries. 5/15/2014 0.05 Angel Investors Device Allocation_List2014.docx 0.00 0.05 0.00 Developer of a platform to enable entirely new care models by providing solutions that are lower cost, greater convenience, and superior http://mn.gov/deed/images/ATC_Credit_ Vios Minneapolis Minneapolis MN Early clinical value. 3/30/2014 0.07 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.07 Promotes and advances best practices through the latest technologies in healthcare http://mn.gov/deed/images/ATC_Credit_ Vital Simulations Minneapolis Minneapolis MN Early education. 3/30/2014 0.44 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.44 http://www.sec.gov/Archives/edgar/data Developer of products for the wound care Undisclosed Venture /1359010/000135901014000001/xslFor Wound Care Technologies Minneapolis Minneapolis MN Undisclosed market that reduce healing time for wounds. 2/20/2014 0.45 Investor(s) Device mDX01/primary_doc.xml 0.00 0.45 0.00
Medical device company that provides surgical and medical instruments for use in aesthetic, http://mn.gov/deed/images/ATC_Credit_ Zift Medical Minneapolis Minneapolis MN Angel orthopedic or endoscopic surgery. 3/11/2014 0.35 Angel Investors Device Allocation_List2014.docx 0.00 0.35 0.00 Devleloper of an online software‐as‐a‐service http://medcitynews.com/2014/11/digital‐ diagnosis and treatment option for minor medicine‐startup‐zipnosis‐raises‐1‐5m‐ Zipnosis Minneapolis Minneapolis MN Seed health conditions. 11/18/2014 1.50 Arthur Ventures SW/Services seed‐funding/ 0.00 0.00 1.50 Devleloper of an online software‐as‐a‐service diagnosis and treatment option for minor http://mn.gov/deed/images/ATC_Credit_ Zipnosis Minneapolis Minneapolis MN Early health conditions. 5/152014 0.15 Angel Investors SW/Services Allocation_List2014.docx 0.00 0.00 0.15 http://www.sec.gov/Archives/edgar/data Developer of single‐use non‐implantable Undisclosed Venture /1605144/000160514414000001/xslFor Zurich Medical Minneapolis Minneapolis MN Convertible Debt devices for cardiac and vascular procedures. 4/8/2014 0.39 Investor(s) Device mDX01/primary_doc.xml 0.00 0.39 0.00
Series Developer of medical devices for the http://www.bizjournals.com/twincities/p D/Convertible treatment of spine conditions implicit in lower rint‐edition/2014/10/03/funding‐ Zyga Technology Minnetonka Minneapolis MN Debt back pain. 9/25/2014 10.00 Silicon Valley Bank Device roundup‐zyga‐and‐exosite.html 0.00 10.00 0.00
Developer of products to supplement cell culture used in growing stem cell and primary http://mn.gov/deed/images/ATC_Credit_ Mill Creek Life Sciences Rochester Rochester MN Early cells for clinical and research markets. 5/19/2014 3.58 Angel Investors Biotech Allocation_List2014.docx 3.58 0.00 0.00
Developer of an easy‐to‐inject liquid pure http://www.bizjournals.com/stlouis/blog collagen for natural and stable integration into Undisclosed Venture /biznext/2014/11/botox‐alternative‐ EternoGen Aesthetics Columbia Columbia MO Early the dermis. 11/3/2014 2.02 Investor(s) Biotech startup‐raises‐another‐1‐million.html 2.02 0.00 0.00
Developer of an in situ autologous http://www.bizjournals.com/stlouis/blog (therapeutic) cancer vaccine for the treatment /biznext/2014/09/cancer‐curing‐startup‐ ImmunoPhotonics Columbia Columbia MO Series A of metastatic cancers. 9/4/2014 1.80 Cultivation Capital Biotech raises‐1‐8‐million‐from‐st.html?page=all 1.80 0.00 0.00
Developer of a search tool that aggregates http://www.bizjournals.com/stlouis/print‐ medical information databases for care edition/2014/02/14/funding‐for‐st‐louis‐ MedSocket of Missouri Columbia Columbia MO Undisclosed providers. 2/18/2014 0.05 Capital Innovators SW/Services tech‐startups.html?page=all 0.00 0.00 0.05 http://www.pehub.com/2014/02/epidar Developer of kinase inhibitors to treat cancer ex‐capital‐invests‐in‐confluence‐life‐ Confluence Life Sciences St. Louis St. Louis MO Series A and inflammatory disease. 2/19/2014 1.00 Epidarex Capital Biotech sciences/ 1.00 0.00 0.00
Developer of a technology application that http://www.bizjournals.com/stlouis/blog integrates pharmaceutical drug data in an easy‐ /biznext/2014/08/biogenerator‐invests‐in‐ Edis Solutions St. Louis St. Louis MO Early to‐use automated solution. 8/25/2014 Undisclosed BioGenerator SW/Services medtech‐startup‐edis.html?page=all 0.00 0.00 0.00
Page 10 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
Provider of health insurance and software services to healthcare companies, including Camden Partners, Kleiner http://www.sec.gov/Archives/edgar/data collaboration, reimbursement, clinical Perkins Caufield & Byers, /1421621/000142162114000001/xslFor Essence Group Holdings Maryland Heights St. Louis MO Later informatics and information technology. 5/12/2014 71.03 Sandbox Industries SW/Services mDX01/primary_doc.xml 0.00 0.00 71.03
Developer of anti‐cancer medications centered upon a portfolio of COX‐2 inhibitors that will http://euclises.com/wp‐ maximize anti‐cancer efficacy and restore the content/uploads/2014/09/Euclises‐Series‐ Euclises Pharmaceuticals St. Louis St. Louis MO Series A patient immune response. 9/9/2014 1.30 Cultivation Capital Biotech A‐Press‐Release‐v14.pdf 1.30 0.00 0.00 http://www.sec.gov/Archives/edgar/data Developer of biologic products for orthopedic Undisclosed Venture /1052380/000095013814000321/xslFor ISTO Technologies St. Louis St. Louis MO Undisclosed and spinal applications. 3/17/2014 8.00 Investor(s) Biotech mDX01/primary_doc.xml 8.00 0.00 0.00
Developer of diagnostics that monitor http://www.bizjournals.com/stlouis/blog inflammation in time and detect adverse /biznext/2014/11/kypha‐closes‐on‐3‐5‐ Kypha (Kentucky Pharmaceuticals) St. Louis St. Louis MO Early inflammatory events at onset. 11/21/2014 3.50 Arsenal Capital Management Biotech million‐funding.html?page=all 3.50 0.00 0.00 Developer of medical devices for minimally http://www.sec.gov/Archives/edgar/data invasive delivery of interventional oncology Undisclosed Venture /1312458/000095013814000416/xslFor Veran Medical Technologies St. Louis St. Louis MO Undisclosed therapies. 5/9/2014 5.00 Investor(s) Device mDX01/primary_doc.xml 0.00 5.00 0.00
Developer of medical devices for minimally http://www.bizjournals.com/stlouis/blog invasive delivery of interventional oncology /biznext/2014/10/veran‐medical‐ Veran Medical Technologies St. Louis St. Louis MO Later therapies. 10/21/2014 12.00 Prolog Ventures Device technologies‐raises‐12‐million.html 0.00 12.00 0.00 Producer of supplements for reducing risk of ZeaVision Holdings Chesterfield St. Louis MO Early age related vision loss. 10/1/2014 3.00 DSM Venturing Biotech PitchBook 3.00 0.00 0.00
United States: Cure Sanfilippo Foundation, Sanfilippo Research Foundation (SRF), Team Sanfilippo, the Abby Grace Foundation and the National MPS Society; Spain: Stop Sanfilippo and Sanfilippo Drug development company for patients with B Foundation; Geneva, lysosomal storage diesases. Abeona has Switzerland: Fondation http://www.sec.gov/Archives/edgar/data exclusive rights to develop its two lead Sanfilippo; Mexico: Red /1612434/000161243414000001/xslFor Abeona Therapeutics Cleveland Cleveland OH Series A products for Sanfilippo syndrome. 11/7/2014 3.61 Sanfilippo Foundation BioTech mDX01/primary_doc.xml 3.61 0.00 0.00 Developer of new small molecule therapeutics, http://www.sec.gov/Archives/edgar/data exploiting a novel target for the treatment of Undisclosed Venture /1601320/000160132014000002/xslFor Aeromics Cleveland Cleveland OH Series A CNS edema. 3/19/2014 1.35 Investor(s) Biotech mDX01/primary_doc.xml 1.35 0.00 0.00 Secondary Developer of therapeutic product candidates Transaction; designed to extend and enhance the quality of Athersys Cleveland Cleveland OH Public Offering human life. 1/15/2014 20.50 Undisclosed Investors Biotech Pitchbook 20.50 0.00 0.00 http://www.sec.gov/Archives/edgar/data Developer of spinal implants to restore the Undisclosed Venture /1221902/000122190214000001/xslFor Axiomed Spine Garfield Heights Cleveland OH Later native motion of the spine. 4/29/2014 1.07 Investor(s) Device mDX01/primary_doc.xml 0.00 1.07 0.00 Drug development company associated with BioEnterprise data and The Harrington Project for Discovery & http://www.crainscleveland.com/article/ BioMotiv Shaker Heights Cleveland OH Undisclosed Development. 9/25/2014 29.00 Takeda Pharmaceutical Co. BioTech 20140925/FREE/140929889 29.00 0.00 0.00 Developer of an advanced wellness program http://www.sec.gov/Archives/edgar/data composed of nutrition, fitness, lifestyle, and Undisclosed Venture /1512148/000151214814000001/xslFor Bio Wellness Copley Cleveland OH Undisclosed tracking modules. 2/24/2014 0.06 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 0.06 Developer of an advanced wellness program http://www.sec.gov/Archives/edgar/data composed of nutrition, fitness, lifestyle, and Undisclosed Venture /1512148/000151214814000002/xslFor Bio Wellness Copley Cleveland OH Undisclosed tracking modules. 2/26/2014 0.09 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 0.09 https://www.sec.gov/Archives/edgar/dat Provider of thin, flexible, and eco‐friendly Undisclosed Venture a/1397714/000139771414000002/xslFor Blue Spark Technologies Westlake Cleveland OH Undisclosed printed battery solutions. 8/16/2014 1.65 Investor(s) Device mDX01/primary_doc.xml 0.00 1.65 0.00
Page 11 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
Provider of outcomes‐based wellness program http://www.crainscleveland.com/article/ for companies, organizations, brokers, and 20140812/FREE/140819963/bravo‐ Bravo Wellness Cleveland Cleveland OH Series A other wellness providers. 8/12/2014 22.00 ABS Capital Partners SW / Services wellness‐secures‐22‐million‐investment# 0.00 0.00 22.00
http://www.bioportfolio.com/news/articl Developer of a technology to aid navigation e/2175116/Centerline‐Biomedical‐spun‐ and reduce radiation exposure to patients and off‐from‐Cleveland‐Clinic‐and‐gets‐500k‐ Centerline Biomedical Cleveland Cleveland OH Seed caregivers during endovascular procedures. 11/13/2014 0.50 Ohio BioValidation Fund Device in‐seed.html 0.00 0.50 0.00 A medical device that measures cervical length to help identify and manage high risk pregnant Chrysalis, Aboretum and CerviLenz Chagrin Falls Cleveland OH Undisclosed woment for preterm birth. 8/15/2014 5.00 Kresge Device BioEnterprise data 0.00 5.00 0.00
Manufacturer of surgical devices for stimulation, location, and evaluation of nerves Checkpoint Surgical Cleveland Cleveland OH Series B and muscles during surgical procedures. 7/23/2014 1.60 Undisclosed Device BioEnterprise data 0.00 1.60 0.00 https://www.sec.gov/Archives/edgar/dat A clinical reference laboratory based on a/1528499/000152849914000002/xslFor Cleveland HeartLab Cleveland Cleveland OH Undisclosed biomarkers to predict cardiovascular risk. 7/9/2014 2.75 Undisclosed BioTech mDX01/primary_doc.xml 2.75 0.00 0.00 Confidential Companies (16) Cleveland Cleveland OH Confidential Confidential Confidential 231.81 Confidential Confidential JumpStart Data, BioEnterprise Data Confidential Confidential Confidential http://www.sec.gov/Archives/edgar/data /1591198/000159119814000001/xslFor Pharmacy Benefit Management service mDX01/primary_doc.xml provider providing full range of injectable and http://www.sec.gov/Archives/edgar/data infusion biopharma products directly to /1620015/000162001514000001/xslFor Envision Pharmaceutical Holdings Twinsburg Cleveland OH Undisclosed patients or their physicians. 9/18/2014 58.28 Undisclosed SW/Services mDX01/primary_doc.xml 0.00 0.00 58.28
Research and development firm specializing in molecular biology, biochemistry, neurobiology http://enzymebiosystems.com/unregister EnzymeBioSystems Chagrin Falls Cleveland OH PIPE and drug discovery. 6/9/2014 0.98 Undisclosed BioTech ed‐sale‐of‐equity‐securities/ 0.98 0.00 0.00
Developer of ultra high resolution multimodality diagnostic imaging technology for early detection and monitoring of neurodegenerative disorders, cardiovascular Undisclosed Venture FMI Medical Systems Akron Cleveland OH Seed disease, breast cancer, and prostate cancer. 1/1/2014 3.77 Investor(s) Device BioEnterprise Data 0.00 3.77 0.00
Delivers a complete SmartPhone‐based clinical http://medcitynews.com/2014/03/angel‐ drug trial data management system for Undisclosed Venture group‐bets‐250k‐app‐device‐software‐ iRx Reminder Cleveland Cleveland OH Seed research centers. 3/7/2014 0.25 Investor(s) SW/Services trifecta‐better‐care‐compliance/ 0.00 0.00 0.25
Developer of the Epidural Needle Guidance http://www.sec.gov/Archives/edgar/data System and a disposable medical device which Undisclosed Venture /1607168/000160716814000002/xslFor Lumoptik Eye Cleveland Cleveland OH Convertible Debt gives anesthetists real‐time feedback. 5/5/2014 0.12 Investor(s) Device mDX01/primary_doc.xml 0.00 0.12 0.00
Developer of a wrist‐worn activity tracker; provides rewards based on achievements Undisclosed Venture MOVable Brecksville Cleveland OH Early performed while wearing the band. 3/1/2014 0.75 Investor(s) Device BioEnterprise Data 0.00 0.75 0.00 HLM Venture Partners, Draper Triangle Ventures, Early Stage Provider of staff scheduling and shift Partners, Fifth Third Capital, management software for healthcare Glengary LLC, West Capital http://www.crainscleveland.com/article/ OnShift Cleveland Cleveland OH Series C providers. 2/3/2014 7.00 Advisors SW/Services 20140203/FREE/140209970 0.00 0.00 7.00
Provider of services for the critical unmet need of addressing billing, quality of care, care Socrates Cleveland Cleveland OH Angel pathway and profitability analysis. 6/2/2014 0.30 Undisclosed Angel Investor(s) SW/Services BioEnterprise Data 0.00 0.00 0.30
Developer of medical devices that address post http://www.sec.gov/Archives/edgar/data stroke pain through the use of peripheral Undisclosed Venture /1532647/000153264714000001/xslFor SPR Therapeutics Cleveland Cleveland OH Convertible Debt nerve stimulation technology. 6/6/2014 3.93 Investor(s) Device mDX01/primary_doc.xml 0.00 3.93 0.00
Page 12 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services Developer of medical foods, drugs and therapies that address unmet medical needs by safely and effectively improving the http://www.sec.gov/Archives/edgar/data bioavailability of naturally occuring Undisclosed Venture /1603985/000116267714000029/xslFor Sulfagenix Cleveland Cleveland OH Undisclosed compounds. 3/31/2014 1.30 Investor(s) Biotech mDX01/primary_doc.xml 1.30 0.00 0.00 http://www.sec.gov/Archives/edgar/data Developer of repurposed drugs for new Undisclosed Venture /1479295/000155691914000002/xslFor TheraVasc Cleveland Cleveland OH Undisclosed applications. 3/11/2014 0.35 Investor(s) Biotech mDX01/primary_doc.xml 0.35 0.00 0.00 Developer of immuno‐oncolytic therapy that http://www.sec.gov/Archives/edgar/data stimulates patient's own immune system to Undisclosed Venture /1609754/000160975414000001/xslFor Western Oncolytics Cleveland Cleveland OH Seed combat cancer cells. 6/3/2014 0.27 Investor(s) Biotech mDX01/primary_doc.xml 0.27 0.00 0.00
OrbiMed, Athenian Venture Partners, Kearny Venture Partners, Novartis Venture Funds, Satter Investment Management, Triathlon http://www.bizjournals.com/cincinnati/n Medical Ventures, Venture ews/2014/04/23/cincinnati‐biopharma‐ Aerpio Therapeutics Cincinnati Cincinnati OH Early Developer of therapies for vascular diseases. 4/23/2014 22.00 Investors Biotech company‐nets‐22m‐investment.html 22.00 0.00 0.00 Developer of drugs for the treatment of bronchopulmonary dysplasia, pulmonary http://www.airwaytherapeutics.com/ne Airway Therapeutics Cincinnati Cincinnati OH Series A hypertension, and asthma. 9/10/2014 4.60 CincyTech, Queen City Angels Biotech ws/press/ 4.60 0.00 0.00
Allos Ventures, Cincinnati Provides genetic information to help Children's Hospital Medical physicians select the right medication for Center, CincyTech, Claremont https://www.sec.gov/Archives/edgar/dat patients with depression, anxiety, chronic pain, Creek Ventures, Sequoia a/1453751/000145375114000001/xslFor Assurex Health Mason Cincinnati OH Late Stage ADHD and other neuropsychiatric disorders. 12/23/2014 37.39 Capital, Mayo Clinic SW/Service mDX01/primary_doc.xml 0.00 0.00 37.39 http://www.sec.gov/Archives/edgar/data Undisclosed Venture /1619825/000089225114000085/xslFor Enable Injections Franklin Cincinnati OH Early Wearable drug delivery/injector platform. 9/18/2014 2.00 Investor(s) Device mDX01/primary_doc.xml 0.00 2.00 0.00
Ischemia Care (ISC) is commercializing a clinically developed blood test to stratify http://www.sec.gov/Archives/edgar/data ischemic stroke patients by cause, leading to Undisclosed Venture /1525868/000089225114000092/xslFor Ischemia Care Oxford Cincinnati OH Seed timely diagnosis and treatment. 9/25/2014 1.92 Investor(s) Biotech mDX01/primary_doc.xml 1.92 0.00 0.00 http://www.sec.gov/Archives/edgar/data Tinnitus alleviation system compatible with Undisclosed Venture /1621997/000162199714000001/xslFor Sanuthera Athens Cincinnati OH Convertible Debt hearing aids. 10/1/2014 0.11 Investor(s) Device mDX01/primary_doc.xml 0.00 0.11 0.00 Developer and provider of data management tools designed to improve operational https://www.sec.gov/Archives/edgar/dat efficiencies throughout the healthcare a/1609215/000160921514000001/xslFor Aver Informatics Columbus Columbus OH Series A industry. 5/27/2014 8.50 GE Ventures, Drive Capital SW/Services mDX01/primary_doc.xml 0.00 0.00 8.50 http://www.sec.gov/Archives/edgar/data Developer of a smart connected toothbrush /1616199/000161619914000001/xslFor Beam Technologies Columbus Columbus OH Series A that beams data to smartphones. 8/11/2014 1.00 Drive Capital Device mDX01/primary_doc.xml 0.00 1.00 0.00 Provides workflow automation, decision support and behavior change tools, including a Draper Triangle Ventures, http://www.prnewswire.com/news‐ care management platform designed to Hopen Life Science Ventures, releases/bjond‐closes‐325‐million‐in‐ Bjond Columbus Columbus OH Series A improve patients' lives. 4/4/2014 3.25 TriStar Technology Ventures SW/Services series‐a‐financing‐253878631.html 0.00 0.00 3.25 Developer of a non‐invasive method for http://www.sec.gov/Archives/edgar/data detecting the presence of a right‐to‐left Undisclosed Venture /1027488/000094926514000002/xslFor Cardiox Columbus Columbus OH Undisclosed cardiac shunt 4/4/2014 3.16 Investor(s) Device mDX01/primary_doc.xml 0.00 3.16 0.00 http://www.sec.gov/Archives/edgar/data Undisclosed Venture /1526186/000152618614000002/xslFor HealthSpot Columbus Columbus OH Undisclosed Provider of primary healthcare kiosks. 5/2/2014 7.90 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 7.90 https://www.sec.gov/Archives/edgar/dat Undisclosed Venture a/1526186/000152618614000003/xslFor HealthSpot Columbus Columbus OH Bridge Provider of primary healthcare kiosks. 11/14/2014 3.14 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 3.14 https://www.sec.gov/Archives/edgar/dat Xerox and other undisclosed a/1526186/000152618614000004/xslFor HealthSpot Columbus Columbus OH Bridge Provider of primary healthcare kiosks. 11/25/2014 6.00 investors SW/Services mDX01/primary_doc.xml 0.00 0.00 6.00
Page 13 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services http://www.pehub.com/2014/01/ge‐ Provider of care coordination services between GE Ventures, Altaris Capital ventures‐and‐altaris‐capital‐partners‐ Quantum Health Columbus Columbus OH Undisclosed patients and the healthcare industry. 1/22/2014 Undisclosed Partners SW/Services invest‐in‐quantum‐health/ 0.00 0.00 Undisclosed
Developer of intra and extra corporeal gas http://www.bizjournals.com/pittsburgh/ exchange devices for the treatment of acute New and Existing Venture blog/financial‐district/2014/05/alung‐ Alung Technologies Pittsburgh Pittsburgh PA Later and chronic respiratory disorders. 5/27/2014 10.01 Investor(s) Device raises‐10m.html 0.00 10.01 0.00
Allos Venture, Birchmere Ventures, Blue Tree Allied Angels, Eagle venture, Innovation Works, Pittsburgh Developer of an intra and extra corporeal gas Life Sciences Greenhouse, https://www.sec.gov/Archives/edgar/dat exchange devices for the treatment of acute Smithfield Trust Company, a/1179295/000117929514000003/xslFor Alung Technologies Pittsburgh Pittsburgh PA Later and chronic respiratory disorders. 7/14/2014 0.83 West Capital Device mDX01/primary_doc.xml 0.00 0.83 0.00
Creates biologically active plastics for treating Carmell Therapeutics Pittsburgh Pittsburgh PA Undisclosed bone and connective tissue injuries. 2/14/2014 0.10 Innovation Works Biotech Innovation Works records 0.10 0.00 0.00
http://www.bizjournals.com/pittsburgh/ Creates biologically active plastics for treating blog/financial‐district/2014/06/carmell‐ Carmell Therapeutics Pittsburgh Pittsburgh PA Undisclosed bone and connective tissue injuries. 6/12/2014 0.68 LeHigh Valley Angels Biotech plans‐bigger‐capital‐round‐later‐for.html 0.68 0.00 0.00
Creates biologically active plastics for treating Carmell Therapeutics Pittsburgh Pittsburgh PA Undisclosed bone and connective tissue injuries. 6/12/2014 0.06 Innovation Works Biotech Innovation Works records 0.06 0.00 0.00
Provider of magnetic resonance imaging (MRI) contrast agents that enable scientists and clinicians to monitor the position and quantity Undisclosed Venture Celsense Pittsburgh Pittsburgh PA Later of transplanted cells non‐invasively in vivo. 9/9/2014 0.27 Investor(s) Biotech PItchBook 0.27 0.00 0.00
Developer of technologies for cancer Ben Franklin Technology http://www.keystoneedge.com/features/ Cernostics Pittsburgh Pittsburgh PA Fourth diagnosis. 3/25/2014 0.10 Partners Biotech benfranklinregionalecdev032714.aspx 0.10 0.00 0.00 Golden Seeds, New York Angels, Tech Coast Angels, http://www.bizjournals.com/pittsburgh/ Developer of drugs for Alzheimers and other Pittsburgh Life Sciences news/2014/04/03/cognition‐therapeutics‐ Cognition Therapeutics Pittsburgh Pittsburgh PA Undisclosed neurodegenerative distorders. 4/3/2014 5.98 Greenhouse Biotech raises‐6m‐from‐angel‐groups.html 5.98 0.00 0.00 http://www.coheramedical.com/press_ro Developer of absorbable surgical adhesives om/entry/cohera_medical_inc._closes_2 Cohera Medical Pittsburgh Pittsburgh PA Series D and sealants. 1/15/2014 9.30 Innovation Venture Device 6.3m_series_d_round 0.00 9.30 0.00 http://www.bizjournals.com/pittsburgh/ blog/morning‐edition/2014/06/complexa‐ raises‐ 13m.html?utm_source=feedburner&utm _medium=feed&utm_campaign=Feed%3 Developer of therapies for the treatment of A+bizj_national+(Bizjournals+National+Fe Complexa Pittsburgh Pittsburgh PA Series B inflammatroy and metabolic diseases. 6/4/2014 13.00 JAFCO Biotech ed) 13.00 0.00 0.00 http://www.sec.gov/Archives/edgar/data Provider of professional diagnostic imaging Undisclosed Venture /1461475/000146147514000001/xslFor Foundation Radiology Pittsburgh Pittsburgh PA Later services for care centers. 6/26/2014 2.50 Investor(s) SW/Services mDX01/primary_doc.xml 0.00 0.00 2.50 Creates scientifically formulated skincare Futurederm Pittsburgh Pittsburgh PA Undisclosed products. 5/1/2014 0.04 Innovation Works Biotech Innovation Works records 0.04 0.00 0.00 http://www.bizjournals.com/pittsburgh/ Provides a telemedicine service to connect blog/techflash/2014/01/iagnosis‐raises‐ Iagnosis Pittsburgh Pittsburgh PA Undisclosed patients to skin care specialists. 1/6/2014 5.90 Undisclosed SW/Services almost‐6‐million.html 0.00 0.00 5.90 http://www.bizjournals.com/pittsburgh/ blog/financial‐ Provides a telemedicine service to connect district/2014/05/pittsburgh‐area‐health‐ Iagnosis Pittsburgh Pittsburgh PA Undisclosed patients to skin care specialists. 4/10/2014 2.85 Undisclosed SW/Services care‐tech‐firm‐iagnosis.html 0.00 0.00 2.85
Page 14 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
Developer of a non‐invasive medical device https://www.sec.gov/Archives/edgar/dat that provides a functional measure of a Undisclosed Venture a/1482781/000148278114000002/xslFor Intelomed Wexford Pittsburgh PA Series B patient's cardiovascular stability. 7/23/2014 3.85 Investor(s) Device mDX01/primary_doc.xml 0.00 3.85 0.00 http://www.sec.gov/Archives/edgar/data Developer of therapeutics for immunology and /1497598/000089843214000830/xslFor Knopp Biosciences Pittsburgh Pittsburgh PA Undisclosed ALS. 5/30/2014 3.12 Undisclosed Biotech mDX01/primary_doc.xml 3.12 0.00 0.00 https://www.sec.gov/Archives/edgar/dat Developer of therapeutics for immunology and a/1497598/000089843214001226/xslFor Knopp Biosciences Pittsburgh Pittsburgh PA Undisclosed ALS. 12/11/2014 5.03 Undisclosed Biotech mDX01/primary_doc.xml 5.03 0.00 0.00 http://www.sec.gov/Archives/edgar/data Develops diagnostic systems for early cancer /1595276/000159527614000001/xslFor Nanovision Diagnostics Pittsburgh Pittsburgh PA Series A detection. 1/10/2014 1.50 Angel investors Device mDX01/primary_doc.xml 0.00 1.50 0.00 Develops diagnostic systems for early cancer Nanovision Diagnostics Pittsburgh Pittsburgh PA Series A detection. 11/10/2014 0.20 Innovations Works Device Innovation Works records 0.00 0.20 0.00
Manufacturer of non‐invasive medical http://www.bizjournals.com/pittsburgh/ diagnostic equipment used for neurologic, Undisclosed Venture blog/techflash/2014/01/neuro‐kinetics‐ Neuro Kinetics Pittsburgh Pittsburgh PA Undisclosed otologic, and vestibular disorder evaluation. 1/15/2014 0.89 Investor(s) Device raises‐capital.html 0.00 0.89 0.00 Patient monitoring system for assisted living NewCare Solutions Pittsburgh Pittsburgh PA Undisclosed and memory care units. 11/16/2014 0.10 Innovation Works SW/Services Innovation Works records 0.00 0.00 0.10
Diamyd Medical, Innovation Developer of gene delivery products to treat Works, Pittsburgh Life Sciences http://www.bizjournals.com/pittsburgh/ and manage pain and peripheral nerve Greenhouse, UPMC Health news/2014/04/01/periphagen‐raises‐6‐5‐ PeriphaGen Pittsburgh Pittsburgh PA Later damage. 3/31/2014 6.50 Plan Biotech million.html 6.50 0.00 0.00 Digital health management platform to enable dieticians working for grocery store chans to provide health‐conscious shoppers with quality PHRQL Pittsburgh Pittsburgh PA Undisclosed nutrition care. 10/23/2014 0.10 Innovation Works SW/Services Innovation Works records 0.00 0.00 0.10 https://www.sec.gov/Archives/edgar/dat Integrated hospital supply chain solutions a/1613945/000161394514000001/xslFor Prodigo Solutions Pittsburgh Pittsburgh PA Later company. 7/16/2014 12.50 Alliance Healthcare Partners SW/Services mDX01/primary_doc.xml 0.00 0.00 12.50 Software solutions to help healthcare http://www.sec.gov/Archives/edgar/data organizations improve clinical practices to /1593354/000159335413000001/xslFor Qualaris Pittsburgh Pittsburgh PA Undisclosed make safe care easier. 2/21/2014 0.10 Innovation Works SW/Services mDX01/primary_doc.xml 0.00 0.00 0.10
Developer of a therapeutic pain management https://www.sec.gov/Archives/edgar/dat device that generates deep tissue heating over Undisclosed Venture a/1440382/000144038214000002/xslFor ReGear Life Sciences Pittsburgh Pittsburgh PA Later large body areas. 12/9/2014 1.25 Investor(s) Device mDX01/primary_doc.xml 0.00 1.25 0.00
http://www.bizjournals.com/pittsburgh/ blog/financial‐district/2014/04/rijuvin‐ Provider of stethoscope add‐on device to Undisclosed Venture preps‐to‐take‐stethoscope‐to‐new‐ Rijuven Pittsburgh Pittsburgh PA Undisclosed record ECG and acoustical footprints. 4/3/2014 0.31 Investor(s) Device levels.html 0.00 0.31 0.00
Pittsburgh Life Sciences https://www.sec.gov/Archives/edgar/dat Manufacturer of a medical device for fertility Greenhouse Accelerator Fund, a/1618662/000161866214000002/xslFor Rinovum Women's Health Monroeville Pittsburgh PA Early and conception. 12/18/2014 3.00 BlueTree Allied Angels Device mDX01/primary_doc.xml 0.00 3.00 0.00 http://www.bizjournals.com/pittsburgh/ Producer of WiFi and BLE enabled wearable blog/morning‐ devices that update the traditional call bell edition/2014/07/pittsburgh‐startup‐ RistCall Pittsburgh Pittsburgh PA Seed system with a wearable call bell system. 7/17/2014 0.05 DreamIt Ventures Device ristcall‐picked‐for‐philly.html 0.00 0.50 0.00 Develops assays for studying cell‐surface Sharp Edge Labs Pittsburgh Pittsburgh PA Undisclosed proteins. 1/10/2014 0.10 Innovation Works Biotech Innovation Works records 0.10 0.00 0.00 Developer of a new class of targeted biosensors called fluorogenic activating proteins (FAPs), which has lead to a variety of http://www.crunchbase.com/organizatio Sharp Edge Labs Pittsburgh Pittsburgh PA Series B new types of assays. 8/20/2014 0.60 Newlin Investment Company Biotech n/sharp‐edge‐labs 0.60 0.00 0.00 Clinical software that connections patients, TreatSpace Pittsburgh Pittsburgh PA Undisclosed providers, and practices. 1/27/2014 0.15 Innovation Works SW/Services Innovation Works records 0.00 0.00 0.15
Page 15 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services
http://www.cmu.edu/cie/news/2014/no Clinical software that connections patients, vember/1m‐innovation‐investment‐ TreatSpace Pittsburgh Pittsburgh PA Undisclosed providers, and practices. 11/18/2014 1.00 Global Action Summit SW/Services awarded‐to‐treatspace.html 0.00 0.00 1.00
http://www.bizjournals.com/pittsburgh/ print‐edition/2014/02/07/patient‐ Patient monitoring solution for patients with monitoring‐tool‐nears‐ Wellbridge Health Pittsburgh Pittsburgh PA Undisclosed congestive heart failure. 2/7/2014 0.50 Undisclosed SW/Services testing.html?surround=etf&ana=e_article 0.00 0.00 0.50
Manufacturer of compression‐therapy medical https://www.sec.gov/Archives/edgar/dat devices for patients suffering from a/1483094/000148309414000001/xslFor Wright Therapy Products Oakdale Pittsburgh PA Later lymphedema and venous insufficiency. 11/7/2014 4.11 BlueTree Allied Angels Device mDX01/primary_doc.xml 0.00 4.11 0.00 http://techcrunch.com/2014/05/27/aver‐ Developer of a data management platform informatics‐raises‐8‐5‐million‐to‐tackle‐ Aver Informatics Green Bay Green Bay WI Series A simplifying healthcare reimbursement. 5/28/2014 8.50 GE Ventures, Drive Capital SW/Services healthcare‐payments/ 0.00 0.00 8.50 Provider of a cloud‐based engine to help businesses translate HL7 and integrate with http://edgar.secdatabase.com/2733/162 100health / Redox Madison Madison WI Early Stage health system EHR's. 12/11/2014 0.35 Individual Angel Investors SW/Services 792314000001/filing‐main.htm 0 0.00 0.35
Biotechnology company focused on discovery https://www.sec.gov/Archives/edgar/dat of new drugs for cancer treatment, Pavek Investments, Wisconsin a/1412428/000141242814000001/xslFor Centrose Madison Madison WI Later Stage inflammation and other diseases. 1/24/2014 0.10 Investment Partners Biotech mDX01/primary_doc.xml 0.10 0.00 0.00 http://www.datadimensions.com/news/h Provider of software services to healthcare‐ HealthEdge Investment ealthedge‐completes‐investment‐data‐ Data Dimensions Janesville Madison WI Growth related businesses. 11/12/2014 Undisclosed Partners SW/Services dimensions/ 0.00 0.00 0.00 Developer of disposable timers designed to assist medical staff with tracking important http://edgar.secdatabase.com/2276/159 Dock Technologies Madison Madison WI Early Stage tasks. 12/2/2014 0.10 Individual Angel Investors SW/Services 423314000002/filing‐main.htm 0.00 0.00 0.10 Developer of improved biopharmaceutical http://www.sec.gov/Archives/edgar/data methods for treating seasonal and pandemic Venture Management, Knox /1451665/000089706914000281/xslFor FluGen Madison Madison WI Convertible Debt influenza. 2/7/2014 3.40 LLC, Biotech mDX01/primary_doc.xml 3.40 0.00 0.00 https://www.sec.gov/Archives/edgar/dat Developer of medical devices for wound Wisconsin Investment, a/1606055/000160605514000002/xslFor Imbed Biosciences Madison Madison WI Early Stage healing and surgical applications. 9/4/2014 0.68 Strategic Capital Partners Device mDX01/primary_doc.xml 0.00 0.68 0.00 Provider of high‐throughput and turn‐key protein analysis tools for the life science http://edgar.secdatabase.com/274/1572 Intuitive Biosciences Fitchburg Madison WI Early Stage industry. 8/20/2014 0.49 Individual Angel Investors Biotech 79014000001/filing‐main.htm 0.49 0.00 0.00
http://isomark.com/2014/warf‐invests‐ Developer of non‐invasive breath monitoring WARF, Individual Angel 150000‐in‐isomark‐llc‐money‐will‐ Isomark Madison Madison WI Early Stage technology for early infection detection. 4/30/2014 0.35 Investors Biotech support‐patient‐study‐of‐canary/ 0.35 0.00 0.00 Developer of a wireless sensor that enables Stateline Angels, daneVest physical therapists to gauge patient recovery Tech Fund, Wisconsin through force exerted on exercise ropes and Investment Partners, Individual http://edgar.secdatabase.com/2134/892 Kiio Madison Madison WI Early Stage bands. 6/9/2014 0.68 angels SW/Services 71214000470/filing‐main.htm 0.00 0.00 0.68
Madison's Venture Investors, Wisconsin Alumni Research Foundation, Venture Management, State of http://www.xconomy.com/wisconsin/20 Developer of innovative therapies for prostate Wisconsin Investment Board, 14/01/13/madison‐vaccines‐closes‐8m‐ Madison Vaccines Madison Madison WI Series A cancer. 1/13/2014 8.00 Other Venture Investor(s) Biotech series‐a‐round‐for‐prostate‐treatment/ 8.00 0.00 0.00
Developer of energy‐based minimally invasive http://edgar.secdatabase.com/847/8970 NeuWave Medical Madison Madison WI Second medical devices that treat tumors in patients. 10/13/2014 4.76 Convertible Debt Device 6914000422/filing‐main.htm 0.00 4.76 0.00
Page 16 of 17 2014 Year End: Midwest Healthcare Growth Capital Report
Amt. Raised Company City Region State Round Description Closed Date (MM) Investors SubSector Source Biotech Device SW/Services Venture Management, WIP, New Capital Fund, Knox LLC, Chippewa Valley Angel Investors Network, DJW Developer of a particle accelerator that has Advisors, Mendota Venture http://phoenixnuclearlabs.com/pnl‐raises‐ Phoenix Nuclear Labs Madison Madison WI Third applications in medical isotope production. 11/25/2014 2.00 Capital Device 2m‐equity‐financing/ 0.00 2.00 0.00
Developer of nanotechnology and materials science for use in proteomics, cell‐based http://edgar.secdatabase.com/2369/127 Platypus Technologies Madison Madison WI Later Stage studies, and environmental monitoring. 4/15/2014 0.15 Individual angel investors Biotech 118914000003/filing‐main.htm 0.15 0.00 0.00 Developer of a medical device integrating sensors, mobile apps, and analytics to help http://propellerhealth.com/2014/09/pro patients better address and treat COPD and peller‐health‐raises‐14‐5‐million‐series‐b‐ Propeller Health Madison Madison WI Series B asthma. 9/4/2014 14.50 Safeguard, Social+Capital Device financing‐led‐safeguard‐scientifics/ 0.00 14.50 0.00
http://www.xconomy.com/wisconsin/20 Developer of medical tracers and cancer Deerfield Management 14/10/09/deerfield‐pouring‐125m‐into‐ SHINE Medical Technologies Monona Madison WI Early Stage treatment elements. 10/14/2104 125.00 Company Biotech wi‐startup‐shine‐medical‐technologies/ 125.00 0.00 0.00 https://www.sec.gov/Archives/edgar/dat Developer of micro‐invasive intravenous port Undisclosed Venture a/1544817/000089271214000624/xslFor Stealth Therapeutics Madison Madison WI Later Stage devices. 8/22/2014 0.45 Investor(s) Device mDX01/primary_doc.xml 0.00 0.45 0.00 Developer of web‐based programs that Undisclosed Venture Waypoint Healthcare Innovations Madison Madison WI Undisclosed address behavioral health disorders. Undisclosed 0.33 Investor(s) SW/Services Wisconsin Technology Council Data 0.00 0.00 0.33
Developer of cloud‐based care management and analytics services to assist patients with Undisclosed Venture http://edgar.secdatabase.com/1842/158 Wellbe Madison Madison WI Undisclosed their episodes of care. 6/2/2014 0.43 Investor(s) SW/Services 228814000001/filing‐main.htm 0.00 0.00 0.43
Developer of anti‐microbial products to reduce https://www.sec.gov/Archives/edgar/dat the risks associated with surgical site infections a/1551289/000155128914000003/xslFor Zurex Pharma Middleton Madison WI Series B and catheter‐related bloodstream infections. 6/30/2014 4.10 Undisclosed Biotech mDX01/primary_doc.xml 4.10 0.00 0.00
Provider of software to automate the process Jaystreet Technologies Manitowoc Manitowoc WI Seed of filling cancelled appointments. 10/7/2014 0.10 Undisclosed SW/Services Pitchbook 0.00 0.00 0.10 http://edgar.secdatabase.com/2145/892 Elli Health Delafield Milwaukee WI Early Stage Provider of virtual doctor‐on‐demand services. 6/6/2014 0.20 Individual Angel Investors SW/Services 71214000481/filing‐main.htm 0.00 0.00 0.20 Provider of patient access solutions for online scheduling, referral management, and patient http://edgar.secdatabase.com/2240/892 MyHealth Direct Brookfield Milwaukee WI Later Stage engagement. 8/13/2014 0.60 Undisclosed SW/Services 71214000576/filing‐main.htm 0.00 0.00 0.60 http://www.xconomy.com/wisconsin/20 Provider of patient access solutions for online Chrysalis Ventures, 14/10/16/myhealthdirect‐raises‐8m‐ scheduling, referral management, and patient Arboreteum ventures, Area mum‐about‐plans‐for‐milwaukee‐ MyHealth Direct Brookfield Milwaukee WI Later Stage engagement. 10/16/2014 8.00 Capital Corporation SW/Services operations/ 0.00 0.00 8.00 Developer of drugs for the treatment of BlackHorse Investments, http://www.sec.gov/Archives/edgar/data schizophrenia and other central nervous Golden Angels Investors, /1470994/000147099414000001/xslFor Promentis Pharmaceuticals Milwaukee Milwaukee WI Early Stage system disorders. 1/16/2014 2.90 others Biotech mDX01/primary_doc.xml 2.90 0.00 0.00
http://www.jsonline.com/business/somn Developer of an adjustable neck band for Undisclosed Venture a‐therapeutics‐raises‐700000‐from‐angel‐ Somna Therapeutics Germantown Milwaukee WI Undisclosed people suffering from acid reflux disease. 2/3/2014 0.70 Investor(s) Device investors‐b99197081z1‐243313201.html 0.00 0.70 0.00 Developer of the eCareConnect Health Management System, which integrates modules between employer, employee, and Undisclosed Venture http://edgar.secdatabase.com/2820/161 U.S. HealthCenter Thiensville Milwaukee WI Undisclosed other individuals. 9/5/2014 0.15 Investor(s) SW/Services 842414000001/filing‐main.htm 0.00 0.00 0.15 https://www.sec.gov/Archives/edgar/dat Developer of novel products for microscopy a/1550930/000155093014000001/xslFor Microscopy Innovations Marshfield Wausau WI Later Stage laboratories. 8/1/2014 0.41 Undisclosed Device mDX01/primary_doc.xml 0.00 0.41 0.00
Page 17 of 17