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(12) United States Patent (10) Patent No.: US 8,257,714 B2 Aylsworth Et Al

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(12) United States Patent (10) Patent No.: US 8,257,714 B2 Aylsworth Et Al US008257714B2 (12) United States Patent (10) Patent No.: US 8,257,714 B2 Aylsworth et al. (45) Date of Patent: Sep. 4, 2012 (54) COMPOSITIONS AND METHODS FOR 37. A &E SA i. al MMUNOTHERAPY OF CANCER AND 5,780,225 A 7/1998 Wiglertudnicka et al. et al. NFECTIOUS DISEASES 5,792,644 A 8/1998 Vermeulen et al. 5,807,715 A 9, 1998 Morrison et al. (75) Inventors: Charles Aylsworth, Holt, MI (US); 5,821,047 A 10/1998 Garrard et al. ill- 5,969,108 A 10/1999 McCafferty et al. SEEEMS)avid Juckett, East Lansing, MI (US); 6,008,3426,001,363 A 12/1999 TomleyBinger et etal al. John W. Judge, St. Johns, MI (US); 6,100,241 A 8, 2000 Kok et al. Barnett Rosenberg, Holt, MI (US); Igor 33. R 239, ably al y: Zlatkin, Millis,- - - - MA (US); Tatiana 6.451,984W B1 9/2002 Lillehoetalarter et al. Zlatkin, Millis, MA (US) 6,528,485 B1 3/2003 Veronese et al. (73) Assignee: Michigan State University, Lansing, MI FOREIGN PATENT DOCUMENTS (US) EP 239.400 A2 9, 1987 EP 519596 A1 12/1992 (*)c Notice:- r Subject to any disclaimer, the term of this WOEP WO 86,05807592106 A1 10,4f1994 1986 patent is extended or adjusted under 35 WO WO 89.01.036 A1 2, 1989 U.S.C. 154(b) by 793 days. WO WO90,02809 A1 3, 1990 WO WO 91.01134 A1 2, 1991 (21) Appl. No.: 12/102,292 WO WO91,09967 A1 7, 1991 9 WO WO91f10737 A1 7, 1991 WO WO91f10741 A1 7, 1991 (22) Filed: Apr. 14, 2008 WO WO92fO1047 A1 1/1992 WO WO92/04461 3, 1992 (65) Prior Publication Data WO WO92,06180 A1 4, 1992 WO WO92, 18619 A1 10, 1992 US 2009/O136999 A1 May 28, 2009 WO WO92/2O316 A2 11, 1992 WO WO92,22324 A1 12/1992 Related U.S. Application Data (Continued) (62) Division of application No. 10/892,659, filed on Jul. 15, 2004, now Pat. No. 7,393,534. OTHER PUBLICATIONS Wallach, et al. 1995 Vaccine 13(4): 347-354.* (60) Provisional application No. 60/487.336, filed on Jul. 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