the GI Digest Department of Internal Medicine, Division of Gastroenterology and Hepatology

Spring 2017 • Volume 12 • Issue 1 Faculty and Fellows in the News at DDW 2017

Chief Observations The DDW 2017 Issue

Michigan Medicine Gastroenterology and Hepatology Chief Observations 1 faculty, fellows, research scientists and mid-level providers Past, Present and Future 2 will converge at Digestive Disease Week in Chicago, IL from Dr. Carethers 3 May 6–9, 2017. Recognized as one of the top 50 medical meetings by HCEA, Digestive Disease Week® is the world’s Dr. Conjeevaram 4 largest gathering of physicians, researchers and industry Dr. Merchant 5 working in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. DDW provides an DDW Awards and Recognition 6 unparalleled opportunity for our Division to showcase to Distinguished Abstract and Presidential our peers throughout the world the many accomplishments Plenary Sessions 8 we have achieved over the past year. Our strong tradition of Moderators 9 leadership and recognition at DDW continues this year. Research and Topic Forums 11 I am proud to announce that three of our faculty will receive prestigious AGA awards: Dr. John Carethers will receive the AGA Distinguished Mentor Award, Symposia 15 Dr. Hari Conjeevaram, the AGA Distinguished Educator Award, and Dr. Juanita AGA and ASGE Postgraduate Courses Merchant, the Distinguished Achievement Award in Basic Science. Dr. Shrinivas Breakfast with the Expert, Poster Tours 17 Bishu will receive the 2017 AGA–Pfizer Pilot Research Award in Inflammatory Daily Schedule 18 Bowel Disease. We are also very proud of the many division faculty serving in leadership roles to organize this year’s DDW program. Dr. Grace Elta continues to Poster Sessions 24 serve as the chair of the AGA Council. Her committee is responsible for organizing Index 30 all the programming for DDW. At the section level, Dr. John Kao is the vice chair of the Esophageal, Gastric, and Duodenal Disorders Section; Dr. Joel Rubenstein DDW 2017 Receptions chairs the Clinical Practice Section; Dr. Linda Samuelson is the vice chair of the Cellular & Molecular Gastroenterology Section; and Dr. John Wiley is the vice chair UM GI & Hepatology Alumni Reception of the Neurogastroenterology and Motility Section. Saturday, May 6 The Division again has a strong showing at DDW, reflected in the number 6:30 – 10:00 pm of presentations by our faculty and fellows. We have 59 platform presentations Camelot Room, 3rd floor – notably, presentations at a Distinguished Abstract Plenary and the Presidential InterContinental Chicago Magnificent Mile Plenary and 5 state-of-the-art lectures – and 64 posters. The wide range of AGA Awards Ceremony important topics that will be covered include stem cell biology, epithelial cell Sunday, May 7 differentiation and morphogenesis, visceral hypersensitivity, gastroparesis, gut 5:30 – 6:30 pm • reception microbiome, inflammatory bowel disease, gastric metaplasia, intestinal mucosal 6:30 – 7:15 pm • award presentations inflammation and fibrosis, colon and pancreatic cancer, and hepatitis B. Many Grand Ballroom, 7th floor InterContinental Chicago Magnificent Mile of our faculty will serve as forum and symposium moderators, participate in panel discussions and Breakfast with the Expert, and conduct AGA and ASGE ASGE Crystal Awards Postgraduate Courses. Sunday, May 7 6:15 pm • reception 7:30 pm • dinner and program Radisson Blu Aqua Hotel

Spring 2017 The GI Digest 1 Past, Present and Future

Gastroenterology and Hepatology at the University of Michigan Past, Present and Future of Innovation, Clinical Practice and Leadership

In September 2016, the Division of Gastroenterology and Hepatology celebrated the 75th anniversary of the founding of the Division. As part of that celebration the Division held a two-day symposium, “GI and Hepatology at the University of Michigan: Past, Present and Future of Innovation, Clinical Practice and Leadership.” Faculty, fellows, alumni, U-M leadership and friends of the Division were invited to attend.

The Thursday program, moderated by Drs. Chung Owyang and William D. Chey, included Dr. John Carethers, followed by leaders in gastroenterology and hepatology from across the nation, including Drs. Tachi Yamada, Rick Boland and David Lieberman. Distinguished alumni speakers included Drs. Ezra Burstein, Joseph Elmunzer, Michael Kochman, Uri Ladabaum, John Inadomi and Michael Lucey.

The Friday program, moderated by Dr. Juanita Merchant, showcased the achievements of some of our own U-M faculty, including Drs. Anna Lok, Liz Speliotes, John Allen, John Wiley, Peter Higgins, William Chey, Hari Conjeevaram, Thomas Wang, Jason Spence and Nobu Kamada. Mary Petrovich, a philanthropist and friend of the Division, was also on hand to give her personal reflection on patient care and the future of innovation.

On Friday, Medicine Grand Rounds was presented by a special guest, Dr. Daniel K. Podolsky, President of UT Southwestern Medical Center.

The Symposium was followed by a dinner at the beautiful University of Michigan Museum of Art. After a reception, which showcased a five-panel work of art by Bill Burgard that was commissioned for the event, Chung Owyang welcomed guests and introduced Dr. Joel Howell who led guests along an interesting journey of the history of the University and the Division. A video produced just for the occasion was shown, after which Dr. Chey introduced remarks by Drs. James Woolliscroft, Tachi Yamada and Daniel Podolsky. The final toast of the night was given by John Carethers who announced the establishment of the Chung Owyang, MD, Professorship in Gastroenterology and Hepatology. This endowed chair is intended to support future chiefs of the U-M Division of Gastroenterology and Hepatology and will ensure that Dr. Owyang’s legacy of dedication will live on at the University of Michigan in perpetuity.

The history of the Division, from the modest beginning in the 1940s, to the tailgate and football game attended by guests of the 75th Anniversary Celebration, has been artfully captured in a 184-page book, “Honoring the Past, Shaping the Future: 75 Years of Discovery, Innovation and Care”.

2 The GI Digest Spring 2017 DDW 2017 Awards and Recognition

We are proud to announce the following award recipient from the University of Michigan Division of Gastroenterology and Hepatology who will be recognized at DDW 2017. John M. Carethers, MD, AGAF Distinguished Mentor award American Gastroenterological Association AGA is proud to honor John M. Carethers, MD, AGAF with a Distinguished Mentor Award, which recognizes individuals who have made lifelong efforts dedicated to the mentoring of trainees in the field of gastroenterology and for achievements as outstanding mentors throughout their careers. Dr. Carethers' continuous dedication to achieving excellence, his mentorship of GI fellows, postdoctoral fellows, medical students (both in clinical education and in medical research), and undergraduate students, and his rigorous, yet highly supportive style make him deserving of this award. He has an infectious enthusiasm for research and scholarly work and for the field of gastroenterology at large. Dr. Carethers is the John G. Searle Professor and Chair, Department of Internal Medicine and Professor of Human Genetics at Michigan Medicine. He oversees more than 820 faculty, 310 trainees and 1,700 staff. He is a trained gastroenterologist and physician–scientist who focuses his research on colon cancer genetics. He has served as a role model and mentor to GI-focused scientists and clinicians worldwide, and has mentored 56 trainees at all academic levels, with 17 currently holding faculty positions. Among his many mentoring/teaching awards are the University of California, San Diego (UCSD) Department of Medicine Graduating House Staff Teaching Award (1999) and the UCSD Vice-Chancellor’s Award for Mentoring Excellence (2006). Numerous additional honors include membership to the National Academy of Medicine (2012), American Association for the Advancement of Sciences (2015), and the American Academy of Arts & Sciences (2016). An AGA member for over 25 years, Dr. Carethers has contributed tremendously to the organization. He has served on the Underrepresented Minorities Committee and Research Policy Committee, and as vice chair and chair of the AGA Institute Council Gastrointestinal Oncology Section, as well as chair of the section’s nominating committee. He served as a senior associate editor for Gastroenterology, and served as the program chair and as an invited speaker for numerous AGA meetings. In 2016, he received the AGA Institute Gastrointestinal Oncology Section Research Mentor Award. From 2015 to 2016, he served as a mentor for the inaugural class of the AGA Future Leaders Program and as a mentor for the AGA Investing in the Future Student Research Fellowship. Dr. Carethers serves as chair of the Minorities in Cancer Research Council of the American Association for Cancer Research, and is a councilor and soon to be president-elect of the American Association of Physicians. He completed a two-year appointment on the National Commission for Digestive Diseases. Dr. Carethers is an elected member of the American Society for Clinical Investigation, the American Association of Physicians, and the National Academy of Medicine. He has published more than 160 manuscript articles and book chapters that focus on colorectal cancer. Dr. Carethers received his MD with high distinction from Wayne State University. He completed his internship and residency in internal medicine at Massachusetts General Hospital followed by a GI fellowship at U-M. At UCSD, he conducted research on DNA mismatch repair and colorectal cancer pathogenesis, was GI division chief (2004–2009), served as founding director of its NIH-funded GI center, and was the director of the GI NIH T32 grant. He also served as PI of the NIH-funded San Diego State University/UCSD Cancer Center Comprehensive Partnership, which addresses cancer disparities.

Spring 2017 The GI Digest 3 DDW 2017 Awards and Recognition

We are proud to announce the following award recipient from the University of Michigan Division of Gastroenterology and Hepatology who will be recognized at DDW 2017. Hari S. Conjeevaram, MD, MS Distinguished Educator Award American Gastroenterological Association AGA is proud to honor Hari S. Conjeevaram, MD, MS with the AGA Distinguished Educator Award, which recognizes individuals who have made outstanding contributions as educators in gastroenterology on both local and national levels, over a lifelong career.

Dr. Conjeevaram has dedicated his entire academic career to the education, mentorship and empowerment of medical students, residents and fellows. He has been selfless in these efforts and his trainees consider him a shining example of the ideal physician and exemplary educator they aspire to become. He serves as director of the GI Fellowship Training Program and has been actively involved in teaching leadership skills to students through his role as medical director for the University of Michigan student-run free clinic. Dr. Conjeevaram has won numerous awards from the University of Michigan for his teaching, mentorship and humanism in medicine. He has received the H. Marvin Pollard Award for Outstanding Teaching of Residents, the Gold Foundation Leonard Tow Humanism in Medicine Award twice and has been voted Best Teaching Attending six times in his career. He was the only University of Michigan faculty member selected as a faculty inductee in the Alpha Omega Alpha Honor Medical Society in 2015, and received Michigan’s nomination for the Association of American Medical Colleges National Humanism in Medicine Award. Dr. Conjeevaram is active in the education of medical students, residents and fellows globally. He has been instrumental in setting up a Memorandum of Agreement for education and training for medical students, residents and GI fellows at the All India Institutes of Medical Sciences, New Delhi, India. His involvement with the Indian Society of Gastroenterology has allowed him to mentor GI and hepatology trainees from many institutions in India. As an educator, Dr. Conjeevaram continually looks to the future. Through the Global Health and Education platform at the University of Michigan, he leads an educational collaborative initiative focusing on GI fellows' education and training in Ethiopia. Additionally, he is currently working with fellows and faculty to design a “New Educational Pathway” for GI fellows that focuses on innovative methods of teaching and educating fellows, including technology-based teaching, self-learning modules and competency assessment in endoscopy training. In summary, Dr. Conjeevaram is most deserving of the AGA Distinguished Educator Award. Dr. Conjeevaram obtained his medical degree from Madras Medical College, University of Madras, Tamilnadu, India. He completed his master of science in epidemiology and biostatistics at the School of Public Health, University of Michigan, Ann Arbor, Michigan. Dr. Conjeevaram joined the Division of Gastroenterology at the University of Michigan in 2001 as an assistant professor of medicine and has been a professor of medicine since 2013.

4 The GI Digest Spring 2017 DDW 2017 Awards and Recognition

We are proud to announce the following award recipient from the University of Michigan Division of Gastroenterology and Hepatology who will be recognized at DDW 2016. Juanita L. Merchant, MD, PhD Distinguished Achievement Award in Basic Science American Gastroenterological Association AGA is proud to honor Juanita L. Merchant, MD, PhD, with the Distinguished Achievement Award in Basic Science, which recognizes a senior investigator who has made major accomplishments in basic science research that has significantly advanced the science and/or practice of gastroenterology. Dr. Merchant’s discoveries in the field of transcription factors and its application to gastric physiology and pathophysiology are among her many achievements deserving recognition. Dr. Merchant is the H. Marvin Pollard Professor of Gastrointestinal Sciences, a Professor of Internal Medicine and Integrative and Molecular Physiology, and Associate Director of the MD/PhD Medical Scientist Training Program at the University of Michigan. Dr. Merchant began her undergraduate research career after her sophomore year at Stanford University studying lipid metabolism in the rat ileum. She completed her medical degree and PhD in cell biology at Yale University School of Medicine. After completing an internal medicine residency at Massachusetts General Hospital, she returned to the laboratory as a physician–scientist to study the transcriptional control mechanisms underpinning homeostatic and neoplastic development in the luminal GI tract and subsequently completed her clinical fellowship in gastroenterology at the University of California, Los Angeles. Dr. Merchant began her research career by asking a simple, but fundamental question in gastroenterology – how does the hormone gastrin sense acid and maintain homeostasis in the stomach? This question has been the basis of her research for nearly 25 years. Among Dr. Merchant’s foremost achievements are her studies of hedgehog signaling in the stomach during homeostasis and neoplastic transformation. In short, studies from Dr. Merchant’s laboratory have remained exciting, cutting edge and focused on the regulation and downstream targets modulated by elevated gastrin. Dr. Merchant was one of the first assistant investigators in gastroenterology in the Howard Hughes Research Institute, Chevy Chase, MD. She was selected to be a Harold Amos scholar by the Robert Wood Johnson Foundation, a program that supports the transition of minority physicians to careers in academic medicine. At the University of Michigan, Dr. Merchant was recognized when she was transitioning from assistant to associate professor with the Jerome Conn Award, which is given to a junior faculty who shows the most promise in research and mentorship. She has participated on the AGA Research Committee, the AGA Nominating Committee, and the AGA PhD, MD/PhD, DVM Committee, and was chair of the Hormones, Transmitters, Growth Factors, and Their Receptors Section of the AGA Institute Council. She has served on several NIH study sections, including chair of the Molecular Gastroenterology Study Section. Subsequently, she served on the NIDDK Council and was an initial member of the Council of Councils. She currently serves on the NIDDK Board of Scientific Review. Dr. Merchant has been elected into prestigious medical honor societies, including the American Society for Clinical Investigation and the National Academy of Medicine (NAM). Few gastroenterologists or scientists in the field of gastroenterology are members of NAM, further highlighting Dr. Merchant’s outstanding research career over the years and qualifications for this AGA award.

Spring 2017 The GI Digest 5 DDW 2017 Awards and Recognition

Shrinivas Bishu, MD AGA–Pfizer Pilot Research Award in Inflammatory Bowel Disease American Gastroenterological Association (AGA) Research Foundation and Pfizer Inc. This award supports pilot projects proposed by investigators interested in exploring new research directions in inflammatory bowel disease.

Tossapol (Tos) Kerdsirichairat, MD 2017 AGA–GRG Fellow Abstract Prize American Gastroenterological Association (AGA) and Gastroenterology Research Group (GRG) This award encourages trainees to become more involved in digestive disease research.

Ryan J. Law, DO ASGE Cook Medical Don Wilson Award American Society for Gastrointestinal Endoscopy (ASGE) This award provides advanced fellows or junior faculty with the opportunity to train outside of their home country with a premier GI endoscopist or group in order to advance their training.

6 The GI Digest Spring 2017 DDW Awards • 2008–2017

DDW 2008 DDW 2013 Richard J. Saad, MD, MS Grace H. Elta, MD AGA Research Scholar Award AGA Distinguished Clinician Award ASGE Distinguished Educator Award Michael L. Volk, MD, MSc AGA Research Scholar Award Chung Owyang, MD AGA Julius Friedenwald Medal DDW 2009 DDW 2014 Anna S. Lok, MD, FRCP AGA Foundation for Digestive Health and Nutrition Joseph C. Kolars, MD Outstanding AGA Women in Science Award AGA Distinguished Educator Award

Juanita L. Merchant, MD, PhD Richard S. Kwon, MD, MS AGA–Covidien Research and Development Pilot Award in AGA Foundation for Digestive Health and Nutrition Technology Outstanding AGA Women in Science Award Juanita L. Merchant, MD, PhD DDW 2010 AGA Institute Council Section Mentor Award Regulatory Peptides, Cell Signaling & Molecular Biology Section Tadataka Yamada, MD AGA Distinguished Mentor Award M. Bishr Omary, MD, PhD AGA Institute Council Section Mentor Award DDW 2011 Liver and Biliary Section Chung Owyang, MD Linda C. Samuelson, PhD AGA Distinguished Mentor Award AGA Institute Council Morton I. Grossman Lectureship Joel H. Rubenstein, MD John A. Williams, MD, PhD GRG/AGA Young Investigator Award in Clinical Science AGA Distinguished Achievement Award James M. Scheiman, MD DDW 2015 AGA Institute Council Section Mentor Award Esophageal, Gastric & Duodenal Disorders Section William D. Chey, MD AGA Distinguished Clinician Award ASGE Senior Investigator Mentoring Award M. Bishr Omary, MD, PhD Andrea Todisco, MD AGA Distinguished Mentor Award AGA Research Foundation R. Robert and Sally Funderburg Research Scholar Award in DDW 2016 Gastric Biology Related to Cancer Biology Anna S. Lok, MD, FRCP DDW 2012 AGA William Beaumont Prize in Gastroenterology John Del Valle, MD DDW 2017 AGA Distinguished Educator Award John M. Carethers, MD Grace H. Elta, MD AGA Distinguished Mentor Award AGA Institute Council Section Mentor Award Hari S. Conjeevaram, MD, MS Imaging and Advanced Technology Section AGA Distinguished Educator Award Timothy T. Nostrant, MD Juanita L. Merchant, MD, PhD AGA Distinguished Clinician Award AGA Distinguished Achievement Award in Basic Science

Spring 2017 The GI Digest 7 Distinguished Abstract and Presidential Plenary Sessions

Sunday, May 7, 2017 Monday, May 8, 2017 AGA • Cellular & Molecular Gastroenterology AGA • Presidential Plenary Distinguished Abstract Plenary 11:29 am S406 2:06 pm S105a Hepatitis B elimination: Is it possible? Regulation of CD44 expression by bone Anna Lok morphogenetic protein (BMP) signaling and inflammatory stimuli Wei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Linda Samuelson, Elise Demitrack, Fung-yu Huang, Kent-Man Chu, Wai Leung, Andrea Todisco

8 The GI Digest Spring 2017 Moderators

Saturday, May 6, 2017 Saturday, May 6, 2017

8:00 – 9:30 am • AGA Research Forum S105bcd 2:00 – 3:30 pm • AGA Research Symposium S105a Mechanisms of host–mucosal response to injury Mechanisms of Mucosal Repair and H. pylori infection Moderators: Yatrik Shah, Shanthi Srinivasan Moderators: Mohamad El-Zaatari, Nicola Jones 4:00 – 5:30 pm • AGA Research Forum S403b 8:00 – 9:30 am • AGA Translational Symposium S102d Endoscopic quality Metabolic diseases of the liver in adults Moderators: Megan Adams, Lukejohn Day Moderators: Robert Fontana, Ronald Sokol 4:00 – 5:30 pm • AGA Research Forum S406a 8:00 – 9:30 am • AGA Research Symposium S102abc Advances in diagnosis and treatment of IBS Basic science: Solving clinical conundrums in IBD Moderators: Shanti Eswaran, Lucinda Harris Moderators: Peter Higgins, Gerhard Rogler 4:00 – 5:30 pm • AGA Clinical Symposium S502 8:00 – 9:30 am • ASGE Clinical Symposium S401 Kristin and David Peura, MD, Lecture: Help! I can’t Small bowel challenges get rid of H. pylori Moderators: Michael Rice, Carol Semrad Moderators: Emad El-Omar, John Kao

8:00 – 9:30 am • AGA Clinical Symposium S406b 4:00 – 5:30 pm • AGA Clinical Symposium S105bcd Post-ERCP pancreatitis Linking quality and reimbursement in IBD Moderators: Jacques Van Dam, Erik-Jan Wamsteker Moderators: Ziad Gellad, Akbar Waljee

11:30 am–2:00 pm • ASGE Hands-On Workshop South Hall Suturing and Closures Sunday, May 7, 2017 Moderator: Juanita Merchant 8:00 – 9:30 pm • AGA Research Forum S100c 2:00 – 3:30 pm • ASGE Clinical Symposium S404 IBD: Comparative effectiveness studies ERCP optimizing cannulation and outcomes – Moderators: Christina Ha, Ryan Stidham Techniques and controversies Moderators: Michelle Anderson, David Jaffe 10:00 – 11:30 pm • AGA Research Forum S101a

2:00 – 3:30 pm • AGA Clinical Symposium S406b Funderburg Symposium: 25 Years of Gastric Cancer Research Chronic pancreatitis, diabetes and pancreatic cancer: Moderators: C. Richard Boland, Juanita Merchant NIH Consortium

Moderators: Darwin Conwell, Matthew DiMagno 2:00 – 3:30 pm • AGA Clinical Symposium S501

2:00 – 3:30 pm • AGA Translational Symposium S102abc Beyond sporadic colorectal cancer and esophageal adenocarcinoma: Controversies in screening for Intestinal Metaplasia in the Esophagus and Stomach: the “other” GI cancers Highlights of the 2016 Freston Conference Moderators: Loren Laine, Joel Rubinstein Moderators: Robert Genta, Juanita Merchant continued next page

Spring 2017 The GI Digest 9 Moderators

Sunday, May 7, 2017 Tuesday, May 9, 2017

2:00 – 3:30 pm S105a 8:00 – 9:30 am S102d AGA Distinguished Abstract Plenary AGA Committee Sponsored Symposium Cellular and Molecular Gastroenterology Tales from the front lines: How GI practices are Moderators: Charalabos Pothoulakis, Linda Samuelson using quality measurement to drive improvement Moderators: Megan Adams, Ziad Gellad 4:00 – 5:30 pm • AGA Research Forum S403b 8:00 – 9:30 am S104 Upper GI bleeding and appropriate use of PPIs AGA Distinguished Abstract Plenary Moderators: David Armstrong, Jacob Kurlander The Best of Barrett’s, EOE, GERD, H. pylori 4:00 – 5:30 pm S403a Moderators: John Kao, Michael Vaezi AASLD Clinical Plenary 10:00 – 11:30 am • AGA Research Forum E354a Moderators: Kimberly Brown, Anna Lok IBD: Controlled Clinical Trials 4:00 – 5:30 pm S102abc Moderators: Peter Higgins, William Sandborn AGA Basic Science Plenary 10:00 – 11:30 am S502 Moderators: Linda Samuelson, Jerrold Turner AGA Distinguished Abstract Plenary 4:00 – 5:30 pm S104 Clinical Practice AGA Distinguished Abstract Plenary Moderators: Paul Moayyedi, Joel Rubenstein Neurogastroenterology and Motility 10:00 – 11:30 am • AGA Research Forum S503 Moderators: Satish Rao, John Wiley H. pylori: Epidemiology, outcomes and treatment Moderators: Ernst Kuipers, Richard Saad Monday, May 8, 2017 2:00 – 3:30 pm • AASLD Research Forum S403a 8:00 – 9:30 am • AGA Clinical Symposium S105a Health-Care in the Hospital and Clinic for Chronic Taking back power: Options for organizing Liver Disease physicians to enhance bargaining power Moderators: Kiran Bambha, John Magee Moderators: Megan Adams, John Allen 2:00 – 4:00 pm • DDW Clinical Symposium S100c

10:00 – 11:00 am S405 The Best of DDW 2017 AASLD State-of-the-Art Lecture Moderators: Steven Edmundowicz, Grace Elta DILI: Is this pill safe to swallow? Moderators: Robert Fontana, Folasade (Fola) May

10:00 – 11:30 am • AGA Research Forum S100c Outcomes in IBD Moderators: Gil Melmed, Akbar Waljee

10 The GI Digest Spring 2017 Research and Topic Forums

Saturday, May 6, 2017 Saturday, May 6, 2017

8:00 am S405 11:15 am S105a Current diagnoisis of IBS with diarrhea Transcription factor ZBP-89 cooperates with William Chey β-catenin in the Lgr5+ stem cell Ramon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant 8:00 am S104 MAZ promotes colitis-associated colon tumorigenesis 2:15 pm S105bcd through regulation of STAT3 signaling Clustering of esophageal cancer mortality among Daniel Triner, Yatrik M. Shah white men in the United States Joel Rubenstein 8:15 am S104 Nuclear-to-cytosolic shuttling of the DNA mismatch 2:30 pm S100ab repair protein MSH3 requires posttranslational Machine learning models at week 6 of modification and interacts with an inflammation- vedolizumab therapy for ulcerative colitis can related cytosolic complex accurately predict week 52 corticosteroid free Stephanie Tseng-Rogenski, Koji Munakata, Supal Mehta, endoscopic remission Mamoru Uemura, Tsunekazu Mizushima, Masaki Mori, Akbar Waljee, Boang Liu, Kay Sauder, Ji Zhu, Shail Govani, Minoru Koi, John Carethers Ryan Stidham, Peter Higgins

8:30 am S406a 4:00 pm S106 Validation of a tool predicting complications on Absent in melanoma 2 (AIM2) deficiency cross-sectional imaging among young inpatients exacerbates pseudopyloric metaplasia during with Crohn’s disease chronic Helicobacter infection, due to an Jeffrey Berinstein, Jeremy Adler,Akbar Waljee, Ryan Stidham, accumulation of CD8+ T cells in the gastric mucosa Julajak Limsrivilai, Peter Higgins, Shail Govani Mohamad El-Zaatari, Min Zhang, Nobuhiko Kamada, Shrinivas Bishu, Helmut Grasberger, John Kao 9:00 am S105bcd Dendritic cell–derived TGF-β mediates the 4:15 pm S403b induction of Helicobacter-specific regulatory T cell Appropriateness of surveillance interval in non- response essential for maintenance of immune dysplastic Barrett’s esophagus tolerance in mice Anna Tavakkoli, Chaitra Madiyal, Henry Appelman, Maryam Min Zhang, Mohamad El-Zaatari, Kathryn Eaton, Helmut Khodadost, Kimberly Nofz, Val Metko, Grace Elta, David Beer, Grasberger, John Kao Thomas Wang, Joel Rubenstein

9:15 am S104 5:15 pm S403b AGA State-of-the-Art Lecture AGA State-of-the-Art Lecture Inflammatory signaling networks driving Should ADR be the one and only measure of gastrointestinal carcinogenesis colonoscopy quality? Yatrik Shah Sameer Saini

Spring 2017 The GI Digest 11 Research and Topic Forums

Sunday, May 7, 2017 Monday, May 8, 2017

8:00 am S103 8:12 am S100c Prevalence and predictors of IBS-like symptoms Autonomic function in gastroparesis: Relationship in the United States: Results from a survey of over with etiology, gastric emptying and symptom severity 71,000 Americans Linda Anh Nguyen, Laura Wilson, William Hasler, Pankaj Christopher Almario, William Chey, Brennan Spiegel Pasricha, William Snape, Henry Parkman, Irene Sarosiek, Richard McCallum, Kenneth Koch, Gianrico Farrugia, Madhusudan Grover, Braden Kuo, Laura Miriel, James 9:00 am S103 Tonascia, Frank Hamilton, Thomas Abell Tryptophan hydroxlase 1 (TPH1) promoter genotype but not serum serotonin levels identify 8:24 am S100c IBS-D patients more likely to benefit from the low Relationship of symptoms of gastroparesis to FODMAP diet gastric pathophysiology Shanti Eswaran, Juanita Merchant, Amanda Photenhauer, Henry Parkman, Perry Orthey, Mark Van Natta, Alan Maurer, Kenya Jackson, Dennis Madriaga, Fabiyola Selvaraj, Fred Daohai Yu, Frederick Ramsey, Jesus Diaz, Paige Clark, Andrei Princen, William Chey Iagaru, Roberto Fragomeni, William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Nguyen, William Snape, Thomas 10:06 am S106 Abell, Richard McCallum, Irene Sarosiek, John Clarke, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj Pasricha Recurrent acute pancreatitis without underlying overt chronic pancreatitis negatively impacts 8:36 am S100c quality of life Gregory Cote, Dhiraj Yadav, Judah Abberbock, Gong Tang, Reduction in symptoms during provocative meal Adam Slivka, Randall Brand, Michelle Anderson, Peter Banks, testing with insulin pump therapy plus continuous Michele Lewis, John Baillie, Stuart Sherman, Samer Alkaade, glucose monitoring in patients with gastroparesis Stephen Amann, Andres Gelrud, Chris Forsmark, Bimaljit due to poorly controlled diabetes: Relation to Sandhu, Nalini Guda, Darwin Conwell, Thiruvengadam gastric myoelectrical activity Muniraj, C. Mel Wilcox, David Whitcomb, Timothy Gardner Kenneth Koch, William Hasler, Jorge Calles-Escandon, Mark Van Natta, William Snape, Pankaj Pasricha, Linda Anh Nguyen, 4:15 pm S403b Henry Parkman, Richard McCallum, Irene Sarosiek, Thomas Poor adherence to recommendations to prevent Abell, Gianrico Farrugia, Madhusudan Grover, Frank Hami gastrointestinal bleeding among anticoagulation clinic patients 9:00 am S503 Jacob Kurlander, Xiaokui Gu, James Scheiman, Brian How cost affects the treatment choice for irritable Haymart, Eva Kline-Rogers, Sameer Saini, Scott Kaatz, Steve bowel syndrome with diarrhea patients: A cost- Almany, Michael McNamara, Jay Kozlowski, James Froehlich, effectiveness analysis of tricyclic agents and Geoffrey Barnes rifaximin Eric Shah, Elizabeth Andraska, Jonathan Li, Sai Zhang, 5:15 pm S101b William Chey Butyrate regulates transcription factor ZBP-89 and sustains proliferation under low glucose conditions Ramon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant continued next page

12 The GI Digest Spring 2017 Research and Topic Forums

Monday, May 8, 2017 Monday, May 8, 2017

9:12 am S100c 10:45 am S403b AGA State-of-the-Art Lecture Morphomics-based risk stratification model predicts complications after pancreaticoduodenectomy for Gastroparetic symptoms, symptom score and pancreatic cystic neoplasms diagnostic tests – What do they tell and how useful? Alexander Larson, Binu Enchakalody, Nicholas Wang, Diane William Hasler Simeone, Hari Nathan, Clifford Cho, Stewart Wang, Grace Su, Richard Kwon 9:15 am S102d Soluble protein p40 produced by Lactobacillus 11:15 am S100c rhamnosus GG enhances tight junction protein AGA State-of-the-Art Lecture expression and improves epithelial integrity by Behavioral therapies as an adjunct for management preventing alteration of DNA methylation and of IBD histone acetylation in human colonoids Megan Riehl Xu Han, Ji-Yao Li, Sha Huang, Jason Spence, Chung Owyang 2:00 pm S401 AASLD State-of-the-Art Lecture 10:30 am S100c Defining patient-centered outcomes for IBD and Hepatitis B treatment: Current status and prospects for a cure an international, cross-disciplinary consensus Anna Lok Andrew Kim, Charlotte Roberts, Brian Feagan, Rupa Banerjee, Willem Bemelman, Keith Bodger, Marc Derieppe, Axel Dignass, pm Richard Driscoll, Ray Fitzpatrick, Peter Higgins, Paulo Kotze, 2:15 S104 Jillian Meissner, Marian O’Connor, Zhihua Ran, Corey Siegel, Hedgehog pathway activation protects the colon Helen Terry, Welmoed van Deen, Christien Janneke Van during inflammatory colitis Der Woude, Alandra Weaver, Suk-Kyun Yang, Bruce Sands, Michelle Muza-Moons, Audrey Urquhart, Deepa Severine Vermeire, Simon Travis Chandhrasekhar, Deborah Gumucio

10:45 am S501 2:30 pm S404 Clinical profile of early and late onset idiopathic Outcomes of multiple gateway versus single gateway chronic pancreatitis (ICP) and the influence of transluminal endoscopic drainage and necrosectomy known genetic factors in patients with necrotizing pancreatitis and walled-off Michele Lewis, David Whitcomb, Jyothsna Talluri, Judah necrosis (WON) using lumen-apposing metal stents: Abberbock, Andres Gelrud, Peter Banks, Timothy Gardner, results from an endoscopic step-up approach cohort Stephen Amann, Stuart Sherman, Bimaljit Sandhu, Samer Tossapol Kerdsirichairat, Stuart Amateau, J. Shawn Mallery, Alkaade, Vikesh Singh, Darwin Conwell, Gregory Cote, Nalini Guru Trikudanathan, Rajeev Attam, Sidney Walker, Gregory Guda, Chris Forsmark, Charles Wilcox, Thiruvengadam Beilman, Martin Freeman, Mustafa Arain Muniraj, Gong Tang, John Baillie, Randall Brand, Adam Slivka, Michelle Anderson, Dhiraj Yadav 4:24 pm S102d Serum 7C4 levels decrease after low FODMAP diet in IBS patients: A potential mechanism for benefit Shanti Eswaran, Fabiyola Selvaraj, Fred Princen, Patty Tooker, Gulia Harvie, William Chey

Spring 2017 The GI Digest 13 Research and Topic Forums

Tuesday, May 9, 2017 Tuesday, May 9, 2017

8:15 am S404 11:00 am S101a Scoring system developed from an eight-year cohort Bile acids regulate intestinal paneth cell functions of a consistent transluminal endoscopic step-up and contribute to gut dysbiosis induced by high fat approach for walled-off necrosis (WON) to predict feeding new onset diabetes mellitus (WON-DM score) in Hui Zhou, Merritt Gillilland, Jun Gao, Shi-Yi Zhou, Guanpo patients undergoing endoscopic intervention for Zhang, Chung Owyang walled-off necrosis Tossapol Kerdsirichairat, Stuart K. Amateau, Sidney Walker, 2:36 pm S106 Mustafa A. Arain, Rajeev Attam, Gregory Beilman, Guru Gastrointestinal motility and luminal pH influence Trikudanathan, Martin L. Freeman in vivo dissolution and systemic absorption of drug product in human gastrointestinal tract under fed 10:30 am S405 and fasted conditions Antiviral therapy is under-utilized but associated Mark Koenigsknecht, Jason Baker, Ann Fioritto, Yasuhiro with improved survival across tumor and liver Tsume, Bo Wen, Joseph Dickens, Alex Yu, Jeffery Wysocki, disease stages and cancer therapies in HBV-related Kerby Shedden, Barry Bleske, Allen Lee, William Hasler, hepatocellular carcinoma (HCC): Results of a Gordon Amidon, Duxin Sun multicenter United States–Asia cohort of 2307 patients Vincent Chen, Ming-Lun Yeh, An Le, Peggy Tsai, Mijung Jun, 3:00 pm S405 Waqar Saeed, Hyo Young Lee, Pauline Nguyen, Nathan Kim, Chia- Serum concentrations of cartilage oligomeric Yen Dai, Jee-Fu Huang, Chung-Feng Huang, Wan-Long Chuang, matrix protein are correlated with the presence of Dae Won Jun, Young-Suk Lim, Ming-Lun Yu, Mindie Nguyen advanced hepatic fibrosis in untreated hepatitis C

10:45 am S405 Ryan Stidham, Akbar Waljee, Peter Higgins, Anna Lok

Significantly lower rates of cirrhosis and lower 3:00 pm S102d long-term survival in cryptogenic hepatocellular Chronic stress-associated abdominal pain: carcinoma (HCC) compared to viral etiologies: Glucocorticoid receptor mediates interleukin 6– Results of a multi-center international cohort induced down-regulation of epithelial tight junction Tomi Jun, Ju Dong Yang, Ming-Lun Yeh, Vincent L. Chen, protein occludin and enhanced visceral pain Pauline Nguyen, Minh Chung, Nasra H. Giama, Chung-Feng Huang, Chia-Yeh Dai, Jee-Fu Huang, Wan-Long Chuang, Ye Zong, Shengtao Zhu, John Wiley, Shuangsong Hong Ming-Lun Yu, Lewis R. Roberts, Mindie H. Nguyen 3:15 pm S403a 10:54 am S503 They do hurt more: A nationwide study of falls and Efficacy of high-dose dual therapy versus bismuth- injury among patients with cirrhosis containing quadruple therapy for first-line treatment Ghideon Ezaz, Elliot Tapper of Helicobacter pylori infection and an interim report 5:00 pm S101b of multi-center, randomized control study Chi-Tan Hu, Chien-Chih Tung, Chun-Jung Lin, I-Nan Kuo, PGE2 produced by mast cells is critical to induce Bor-Ru Lin, Hong-Long Wang, Jin-De Chen, Mu-Liang Cheng, visceral hypersensitivity in IBS Chia-Tung Shun, Huei-Mi Li, Jui-Sheng Hung, Wei-Yi Lei, Ming Gintautas Grabauskas, Xiaoyin Wu, Kim Turgeon, Chung Jium Shieh, Jau-Min Wong, John Kao, Jyh-Chin Yang Owyang

14 The GI Digest Spring 2017 Symposia

Saturday, May 6, 2017 Sunday, May 7, 2017

8:40 am • AGA Clinical Symposium S100c 8:00 am • ASGE Clinical Symposium S503 How can we impact clinical and research policy? GWC Symposium 2017: Leveling the Playing Field John Allen Current gender and diversity inequities in gastroenterology 9:00 am • AGA Clinical Symposium S100c Grace Elta Panel Discussion Gastroenterology in the Age of Trump 10:43 am • AGA Research Symposium S101a Spencer Dorn, Folasade (Fola) May, John Allen, F. Taylor Funderburg Symposium: 25 Years of Gastric Cancer Research Wootton, Michael Roberts, Kathleen Teixeira Notch pathway induction of gastric tumorigenesis Linda Samuelson 10:44 am • AGA Clinical Symposium S100c

FODMAPs diet – 10 years on and still ticking! 2:00 pm E350 William Chey Rodger C. Haggitt Gastrointestinal Pathology Society Symposium Getting the Most Out of Your Pathologist: Three Illustrative Cases 4:15 pm • AGA Clinical Symposium S502 A rash diagnosis of inflammatory bowel disease Kristin and David Peura, MD, Lecture: Help! I Can’t Get Rid of H. Pylori John Hart, Jami Kinnucan Discussion 2: How to optimize treatment to achieve success with salvage therapy including 4:05 pm • AGA Committee Sponsored Symposium S102d role of H. pylori culture and sensitivity Adding value to your practice: Three trends you should know William Chey Evolving businees models of GI care John Allen

5:05 pm • AGA Committee Sponsored Symposium S102d Panel Discussion Adding value to your practice: Three trends you should know John Allen, Ryan Madanick, Keisa Lynch

Spring 2017 The GI Digest 15 Symposia

Monday, May 8, 2017 Tuesday, May 9, 2017

8:00 am • AGA Clinical Symposium S105a 8:00 am • AGA Committee Sponsored Symposium S102d History of physicians organizing in the United States Setting the stage: The importance of quality John Allen measures in driving improvement in GI John Allen 8:18 am • AGA Clinical Symposium S105a Legal considerations governing physician unionization 9:15 am • AGA Committee Sponsored Symposium S102d Megan Adams Panel Discussion Tales from the front lines: How GI practices are 9:12 am • AGA Clinical Symposium S105a using quality measurement to drive improvement Panel Discussion Ziad Gellad, Megan Adams, John Allen, James Leavitt, Taking Back Power: Options for Organizing Fasiha Kanwal, Steven Carpenter, Corey Siegel Physicians to Enhance Bargaining Power John Allen, Megan Adams, Fred Rosenberg, F. Taylor Wootton 10:30 am • AGA Research Symposium S105a 2:30 pm • AGA Clinical Symposium S105a Menin-MLL inhibitor MI-503 suppresses plasma Early onset colorectal cancer: What’s in your genes? gastrin in a mouse model of hypergastrinemia Elena Stoffel Sinju Sundaresan, Michael Hayes, Jolanta Grembecka, Juanita Merchant 3:06 pm • AGA Clinical Symposium S105bcd

Management of low grade dysplasia: Surveillance 10:54 am • ASGE Clinical Symposium E350 or endoscopic therapy? Imaging: The Next Generation of Optical Diagnostics Joel Rubenstein In vivo molecular imaging 4:00 pm • Best of AGA at DDW in Chinese S403b Thomas Wang Inflammatory Bowel Disorders John Kao 4:00 pm • AGA Clinical Symposium S402

4:15 pm • ASGE Clinical Symposium S401 ASGE/Chinese Society of Gastroenterology (CSGE) International Symposium Special Situations in Endoscopy Pregnancy (ERCP, sedation) Management of anti-thrombotics in elective and Grace Elta emergency endoscopy Michelle Anderson 4:54 pm • AGA Committee Sponsored Symposium S101a The Road to Leadership in GI Private practice pioneers and how to be one John Allen

5:12 pm • AGA Committee Sponsored Symposium S101a Questions and Answers The Road to Leadership in GI Sheila Crowe, Kim Barrett, Michael Nathanson, John Allen

16 The GI Digest Spring 2017 AGA Postgraduate Course ASGE Postgraduate Course

Saturday, May 6, 2017 Monday, May 8, 2017

1:25 pm • AGA Postgraduate Course Arie Crown Theater 7:45 am • ASGE Postgraduate Course S100ab General Session III – The Biliary Tree and Pancreas Best Tips, Worst Mistakes: Lessons From the Masters, Day Two The Full Scope of GI Advances (Day 1) Optimal strategies for managing incidental Chronic pancreatitis pancreatic cysts Matthew DiMagno Michelle Anderson

8:15 am • ASGE Postgraduate Course S100ab Best Tips, Worst Mistakes: Lessons From the Masters, Day Two Video cases, panel discussion, audience Q & A Amitabh Chak, Todd Baron, Nageshwar Reddy, Kenneth Binmoeller, Michelle Anderson, John Baillie

AGA Postgraduate Course Luncheon Breakout Sessions

Saturday, May 6, 2017 Saturday, May 6, 2017

11:45 am E253b 11:45 am E450b Health care advocacy and legislative changes Quality improvement in endoscopy John Allen Grace Elta

DDW Breakfast With the Expert Poster Tours

Sunday, May 7, 2017 Monday, May 8, 2017

6:30 – 7:45 am S405 11:45 am – 12:30 pm South Hall STAT scope: Approach to endoscopic emergencies IBS Session – Poster Tour Michelle Anderson, John Martin William Chey

Spring 2017 The GI Digest 17 Daily Schedule

Saturday, May 6, 2017 Saturday, May 6, 2017

8:00 – 9:30 am • AGA Research Forum S105bcd 9:00 am • AGA Research Forum S105bcd Mechanisms of host-mucosal response to injury and H. pylori Dendritic cell–derived TGF-β mediates the induction of infection Helicobacter-specific regulatory T cell response essential for Moderators: Mohamad El-Zaatari, Nicola Jones maintenance of immune tolerance in mice Min Zhang, Mohamad El-Zaatari, Kathryn Eaton, Helmut Grasberger, John Kao 8:00 – 9:30 am • AGA Translational Symposium S102d Metabolic diseases of the liver in adults 9:15 am • AGA Research Forum • State-of-the-Art Lecture S104 Moderators: Robert Fontana, Ronald Sokol Inflammatory signaling networks driving gastrointestinal carcinogenesis 8:00 – 9:30 am • AGA Research Symposium S102abc Yatrik Shah Basic science: Solving clinical conundrums in IBD Moderators: Peter Higgins, Gerhard Rogler 10:44 am • AGA Clinical Symposium S100c FODMAPs diet – 10 years on and still ticking! 8:00 – 9:30 am • ASGE Clinical Symposium S401 William Chey Small bowel challenges Moderators: Michael Rice, Carol Semrad 11:15 am • AGA Research Forum S105a Transcription factor ZBP-89 cooperates with β-catenin in the 8:00 – 9:30 am • AGA Clinical Symposium S406b Lgr5+ stem cell Post-ERCP pancreatitis Ramon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant Moderators: Jacques Van Dam, Erik-Jan Wamsteker 11:30 am – 2:00 am • ASGE Hands-On Workshop South Hall 8:00 am • AGA Research Forum S405 Suturing and Closures Current diagnoisis of IBS with diarrhea Moderator: Juanita Merchant William Chey 11:45 am • AGA Postgraduate Course Luncheon Breakout E253b 8:00 am • AGA Research Forum S104 MAZ promotes colitis-associated colon tumorigenesis Health care advocacy and legislative changes through regulation of STAT3 signaling John Allen Daniel Triner, Yatrik Shah 11:45 am • AGA Postgraduate Course Luncheon Breakout E450b 8:15 am • AGA Research Forum S104 Quality Improvement in Endoscopy Nuclear-to-cytosolic shuttling of the DNA mismatch repair Grace Elta protein MSH3 requires posttranslational modification and 1:25 pm • AGA Postgraduate Course Arie Crown Theater interacts with an inflammation-related cytosolic complex The Biliary Tree and Pancreas: The Full Scope of GI Advances Stephanie Tseng-Rogenski, Koji Munakata, Supal Mehta, Mamoru Uemura, Chronic pancreatitis Tsunekazu Mizushima, Masaki Mori, Minoru Koi, John Carethers Matthew DiMagno 8:30 am • AGA Research Forum S406a 2:00 – 3:30 pm • ASGE Clinical Symposium S404 Validation of a tool predicting complications on cross-sectional imaging among young inpatients with Crohn’s disease ERCP optimizing cannulation and outcomes – Techniques and controversies Jeffrey Berinstein, Jeremy Adler, Akbar Waljee, Ryan Stidham, Julajak Limsrivilai, Peter Higgins, Shail Govani Moderators: Michelle Anderson, David Jaffe

8:40 am • AGA Clinical Symposium S100c 2:00 – 3:30 pm • AGA Clinical Symposium S406b How can we impact clinical and research policy? Chronic pancreatitis, diabetes and pancreatic cancer: NIH John Allen Consortium Moderators: Darwin Conwell, Matthew DiMagno 9:00 am • AGA Clinical Symposium • Panel Discussion S100c 2:00 – 3:30 pm • AGA Translational Symposium S102abc Gastroenterology in the Age of Trump Spencer Dorn, Folasade (Fola) May, John Allen, F. Taylor Wootton, Michael Intestinal Metaplasia in the Esophagus and Stomach: Roberts, Kathleen Teixeira Highlights of the 2016 Freston Conference Moderators: Robert Genta, Juanita Merchant continued next page

18 The GI Digest Spring 2017 Daily Schedule

Saturday, May 6, 2017 Sunday, May 7, 2017

2:00 – 3:30 pm • AGA Research Symposium S105a 6:30 – 7:45 am • DDW Breakfast With the Expert S405 Mechanisms of Mucosal Repair STAT scope: Approach to endoscopic emergencies Moderators: Yatrik Shah, Shanthi Srinivasan Michelle Anderson, John Martin

2:15 pm • AGA Research Forum S105bcd 8:00 – 9:30 pm • AGA Research Forum S100c Clustering of esophageal cancer mortality among white men in the United States IBD: Comparative effectiveness studies Moderators: Christina Ha, Ryan Stidham Joel Rubenstein 8:00 am • AGA Research Forum S103 2:30 pm • AGA Research Forum S100ab Machine learning models at week 6 of vedolizumab Prevalence and predictors of IBS-like symptoms in the United therapy for ulcerative colitis can accurately predict week 52 States: Results from a survey of over 71,000 Americans corticosteroid free endoscopic remission Christopher Almario, William Chey, Brennan Spiegel Akbar Waljee, Boang Liu, Kay Sauder, Ji Zhu, Shail Govani, Ryan Stidham, Peter Higgins 8:00 am • ASGE Clinical Symposium S503 GWC Symposium 2017: Leveling the Playing Field 4:00 – 5:30 pm • AGA Research Forum S403b Current gender and diversity inequities in gastroenterology Endoscopic quality Grace H. Elta Moderators: Megan Adams, Lukejohn Day 9:00 am • AGA Research Forum S103 4:00 – 5:30 pm • AGA Research Forum S406a Advances in diagnosis and treatment of IBS Tryptophan hydroxlase 1 (TPH1) promoter genotype but not Moderators: Shanti Eswaran, Lucinda Harris serum serotonin levels identify IBS-D patients more likely to benefit from the low FODMAP diet 4:00 – 5:30 pm • AGA Clinical Symposium S502 Shanti Eswaran, Juanita Merchant, Amanda Photenhauer, Kenya Jackson, Kristin & David Peura, MD, Lecture: Help! I can’t get rid of H. pylori Dennis Madriaga, Fabiyola Selvaraj, Fred Princen, William Chey Moderators: Emad El-Omar, John Kao 10:00 – 11:30 pm • AGA Research Symposium S101a 4:00 – 5:30 pm • AGA Clinical Symposium S105bcd Funderburg Symposium: 25 Years of Gastric Cancer Research Linking quality and reimbursement in IBD Moderators: C. Richard Boland, Juanita Merchant Moderators: Ziad Gellad, Akbar Waljee 10:06 am • AGA Research Forum S106 4:00 pm • AGA Research Forum S106 Recurrent acute pancreatitis without underlying overt Absent in melanoma 2 (AIM2) deficiency exacerbates pseudopyloric metaplasia during chronic Helicobacter infection, due to an chronic pancreatitis negatively impacts quality of life accumulation of CD8+ T cells in the gastric mucosa Gregory Cote, Dhiraj Yadav, Judah Abberbock, Gong Tang, Adam Slivka, Randall Brand, Michelle Anderson, Peter Banks, Michele Lewis, John Baillie, Mohamad El-Zaatari, Min Zhang, Nobuhiko Kamada, Shrinivas Bishu, Stuart Sherman, Samer Alkaade, Stephen Amann, Andres Gelrud, Chris Helmut Grasberger, John Kao Forsmark, Bimaljit Sandhu, Nalini Guda, Darwin Conwell, Thiruvengadam 4:15 pm • AGA Clinical Symposium S502 Muniraj, C. Mel Wilcox, David Whitcomb, Timothy Gardner Kristin & David Peura, MD, Lecture: Help! I Can’t Get Rid of H. pylori 10:43 am • AGA Research Symposium S101a Discussion 2: How to optimize treatment to achieve success with salvage therapy including role of H. pylori culture and sensitivity Funderburg Symposium: 25 Years of Gastric Cancer Research William Chey Notch pathway induction of gastric tumorigenesis Linda Samuelson 4:15 pm • AGA Research Forum S403b Appropriateness of surveillance interval in non-dysplastic 2:00 – 3:30 pm • AGA Clinical Symposium S501 Barrett’s esophagus Beyond sporadic colorectal cancer and esophageal Anna Tavakkoli, Chaitra Madiyal, Henry Appelman, Maryam Khodadost, adenocarcinoma: Controversies in screening for the “other” GI Kimberly Nofz, Val Metko, Grace Elta, David Beer, Thomas Wang, Joel cancers Rubenstein Moderators: Loren Laine, Joel Rubinstein 5:15 pm • AGA Research Forum • State-of-the-Art Lecture S403b Should ADR be the one and only measure of colonoscopy continued next page quality? Sameer Saini

Spring 2017 The GI Digest 19 Daily Schedule

Sunday, May 7, 2017 Monday, May 8, 2017

2:00 – 3:30 pm • AGA Distinguished Abstract Plenary S105a 7:45 am • ASGE Postgraduate Course S100ab Cellular and Molecular Gastroenterology Best Tips, Worst Mistakes: Lessons From the Masters, Day Two Moderators: Charalabos Pothoulakis, Linda Samuelson Optimal strategies for managing incidental pancreatic cysts Michelle Anderson 2:00 pm • AGA Clinical Symposium E350 Rodger C. Haggitt Gastrointestinal Pathology Society Symposium 8:00 – 9:30 am • AGA Clinical Symposium S105a Getting the Most Out of Your Pathologist: Three Illustrative Cases Taking back power: Options for organizing physicians to A rash diagnosis of inflammatory bowel disease enhance bargaining power John Hart, Jami Kinnucan Moderators: Megan Adams, John Allen 2:06 pm • AGA Distinguished Abstract Plenary S105a 8:00 am • AGA Clinical Symposium S105a Cellular & Molecular Gastroenterology Regulation of CD44 expression by bone morphogenetic History of physicians organizing in the United States protein (BMP) signaling and inflammatory stimuli John Allen Wei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Linda Samuelson, Elise am AGA Research Forum Demitrack, Fung-yu Huang, Kent-Man Chu, Wai Leung, Andrea Todisco 8:12 • S100c Autonomic function in gastroparesis: Relationship with 4:00 pm – 5:30 pm • AGA Research Forum S403b etiology, gastric emptying and symptom severity Upper GI bleeding and appropriate use of PPIs Linda Anh Nguyen, Laura Wilson, William Hasler, Pankaj Pasricha, William Moderators: David Armstrong, Jacob Kurlander Snape, Henry Parkman, Irene Sarosiek, Richard McCallum, Kenneth Koch, Gianrico Farrugia, Madhusudan Grover, Braden Kuo, Laura Miriel, James 4:00 pm – 5:30 pm • AASLD Plenary Session S403a Tonascia, Frank Hamilton, Thomas Abell Clinical Plenary 8:15 am • ASGE Postgraduate Course S100ab Moderators: Kimberly Brown, Anna Lok Best Tips, Worst Mistakes: Lessons From the Masters, Day Two 4:00 – 5:30 pm • AGA Plenary Session S102abc Video cases, panel discussion, audience Q & A Basic Science Plenary Amitabh Chak, Todd Baron, Nageshwar Reddy, Kenneth Binmoeller, Michelle Moderators: Linda Samuelson, Jerrold Turner Anderson, John Baillie

4:00 – 5:30 pm • AGA Distinguished Abstract Plenary S104 8:18 am • AGA Clinical Symposium S105a Neurogastroenterology and Motility Legal considerations governing physician unionization Moderators: Satish Rao, John Wiley Megan Adams

4:05 pm • AGA Committee Sponsored Symposium S102d 8:24 am • AGA Research Forum S100c Adding Value to Your Practice: Three Trends You Should Know Relationship of symptoms of gastroparesis to gastric Evolving businees models of GI care pathophysiology John Allen Henry Parkman, Perry Orthey, Mark Van Natta, Alan Maurer, Daohai Yu, Frederick Ramsey, Jesus Diaz, Paige Clark, Andrei Iagaru, Roberto Fragomeni, pm AGA Research Forum 4:15 • S403b William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Nguyen, William Poor adherence to recommendations to prevent gastrointestinal Snape, Thomas Abell, Richard McCallum, Irene Sarosiek, John Clarke, Laura bleeding among anticoagulation clinic patients Miriel, James Tonascia, Frank Hamilton, Pankaj Pasricha Jacob Kurlander, Xiaokui Gu, James Scheiman, Brian Haymart, Eva Kline- Rogers, Sameer Saini, Scott Kaatz, Steve Almany, Michael McNamara, Jay 8:36 am • AGA Research Forum S100c Kozlowski, James Froehlich, Geoffrey Barnes Reduction in symptoms during provocative meal testing with insulin pump therapy plus continuous glucose monitoring in 5:05 pm • AGA Committee Sponsored Symposium • Panel Discussion S102d patients with gastroparesis due to poorly controlled diabetes: Adding Value to Your Practice: Three Trends You Should Know Relation to gastric myoelectrical activity John Allen, Ryan Madanick, Keisa Lynch Kenneth Koch, William Hasler, Jorge Calles-Escandon, Mark Van Natta, 5:15 pm • AGA Research Forum S101b William Snape, Pankaj Pasricha, Linda Anh Nguyen, Henry Parkman, Richard McCallum, Irene Sarosiek, Thomas Abell, Gianrico Farrugia, Madhusudan Butyrate regulates transcription factor ZBP-89 and sustains Grover, Frank Hamilton, James Tonascia, Linda Lee proliferation under low glucose conditions continued next page Ramon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant

20 The GI Digest Spring 2017 Daily Schedule

Monday, May 8, 2017 Monday, May 8, 2017

9:00 am • AGA Research Forum S503 10:45 am • AGA Research Forum S403b How cost affects the treatment choice for irritable bowel Morphomics-based risk stratification model predicts syndrome with diarrhea patients: A cost-effectiveness complications after pancreaticoduodenectomy for pancreatic analysis of tricyclic agents and rifaximin cystic neoplasms Eric Shah, Elizabeth Andraska, Jonathan Li, Sai Zhang, William Chey Alexander K. Larson, Binu Enchakalody, Nicholas Wang, Diane M. Simeone, Hari Nathan, Clifford Cho, Stewart Wang, Grace Su, Richard Kwon 9:12 am • AGA Clinical Symposium • Panel Discussion S105a Taking back power: Options for organizing physicians to 11:15 am • AGA Research Forum • State-of-the-Art Lecture S100c enhance bargaining power Behavioral therapies as an adjunct for management of IBD John Allen, Megan Adams, Fred Rosenberg, F. Taylor Wootton Megan Riehl

9:12 am • AGA Research Forum • State-of-the-Art Lecture S100c 11:29 am • AGA Presidential Plenary S406 Gastroparetic symptoms, symptom score and diagnostic tests Hepatitis B elimination: Is it possible? – What do they tell and how useful? Anna Lok William Hasler 11:45 am – 12:30 pm • AGA Poster Tour South Hall 9:15 am • AGA Research Forum S102d IBS Session Soluble protein p40 produced by Lactobacillus rhamnosus William Chey GG enhances tight junction protein expression and improves epithelial integrity by preventing alteration of DNA 2:00 pm • AASLD State-of-the-Art Lecture S401 methylation and histone acetylation in human colonoids Hepatitis B treatment: Current status and prospects for a cure Xu Han, Ji-Yao Li, Sha Huang, Jason Spence, Chung Owyang Anna Lok

10:00 – 11:00 am • AASLD State-of-the-Art Lecture S405 2:15 pm • AGA Research Forum S104 DILI: Is this pill safe to swallow? Hedgehog pathway activation protects the colon during Moderators: Robert Fontana, Folasade (Fola) May inflammatory colitis Michelle Muza-Moons, Audrey Urquhart, Deepa Chandhrasekhar, Deborah 10:00 – 11:30 am • AGA Research Forum S100c Gumucio Outcomes in IBD 2:30 pm • ASGE Topic Forum S404 Moderators: Gil Melmed, Akbar Waljee Outcomes of multiple gateway versus single gateway 10:30 am • AGA Research Forum S100c transluminal endoscopic drainage and necrosectomy in Defining patient-centered outcomes for IBD and an patients with necrotizing pancreatitis and walled-off necrosis international, cross-disciplinary consensus (WON) using lumen-apposing metal stents: results from an Andrew Kim, Charlotte Roberts, Brian Feagan, Rupa Banerjee, Willem Bemelman, endoscopic step-up approach cohort Keith Bodger, Marc Derieppe, Axel Dignass, Richard Driscoll, Ray Fitzpatrick, Tossapol Kerdsirichairat, Stuart Amateau, J. Shawn Mallery, Guru Peter Higgins, Paulo Kotze, Jillian Meissner, Marian O’Connor, Zhihua Ran, Trikudanathan, Rajeev Attam, Sidney Walker, Gregory Beilman, Martin Corey Siegel, Helen Terry, Welmoed van Deen, Christien Janneke Van Der Woude, Freeman, Mustafa Arain Alandra Weaver, Suk-Kyun Yang, Bruce Sands, Severine Vermeire, Simon Traviss 2:30 pm • AGA Clinical Symposium S105a 10:45 am • AGA Research Forum S501 Early onset colorectal cancer: What’s in your genes? Clinical profile of early and late onset idiopathic chronic Elena Stoffel pancreatitis (ICP) and the influence of known genetic factors Michele Lewis, David Whitcomb, Jyothsna Talluri, Judah Abberbock, Andres 3:06 pm • AGA Clinical Symposium S105bcd Gelrud, Peter Banks, Timothy Gardner, Stephen Amann, Stuart Sherman, Bimaljit Management of low grade dysplasia: Surveillance or Sandhu, Samer Alkaade, Vikesh Singh, Darwin Conwell, Gregory Cote, Nalini endoscopic therapy? Guda, Chris Forsmark, Charles Wilcox, Thiruvengadam Muniraj, Gong Tang, John Baillie, Randall Brand, Adam Slivka, Michelle Anderson, Dhiraj Yadav Joel Rubenstein

continued next page

Spring 2017 The GI Digest 21 Daily Schedule

Monday, May 8, 2017 Tuesday, May 9, 2017

4:00 pm • AGA Committee Sponsored Symposium S403b 8:15 am • ASGE Topic Forum S404 Best of AGA at DDW in Chinese Scoring system developed from an eight-year cohort of a Inflammatory Bowel Disorders consistent transluminal endoscopic step-up approach for John Kao walled-off necrosis (WON) to predict new onset diabetes mellitus (WON-DM score) in patients undergoing endoscopic 4:15 pm • ASGE Clinical Symposium S401 intervention for walled-off necrosis Special Situations in Endoscopy Tossapol Kerdsirichairat, Stuart K. Amateau, Sidney Walker, Mustafa A. Arain, Pregnancy (ERCP, sedation) Rajeev Attam, Gregory Beilman, Guru Trikudanathan, Martin L. Freeman Grace Elta 9:15 am • AGA Committee Sponsored Symposium • Panel Discussion S102d 4:24 pm • AGA Research Forum S102d Tales from the front lines: How GI practices are using quality Serum 7C4 levels decrease after low FODMAP diet in IBS measurement to drive improvement patients: A potential mechanism for benefit Ziad Gellad, Megan Adams, John Allen, James Leavitt, Fasiha Kanwal, Steven Carpenter, Corey Siegel Shanti Eswaran, Fabiyola Selvaraj, Fred Princen, Patty Tooker, Gulia Harvie, William Chey 10:00 – 11:30 am • AGA Research Forum E354a 4:54 pm • AGA Committee Sponsored Symposium S101a IBD: Controlled Clinical Trials The Road to Leadership in GI Moderators: Peter Higgins, William Sandborn Private practice pioneers and how to be one 10:00 – 11:30 am • AGA Distinguished Abstract Plenary S502 John Allen Clinical Practice 5:12 pm • AGA Committee Sponsored Symposium S101a Moderators: Paul Moayyedi, Joel Rubenstein Questions and Answers 10:00 – 11:30 am • AGA Research Forum S503 The Road to Leadership in GI H. pylori: Epidemiology, outcomes and treatment Sheila Crowe, Kim Barrett, Michael Nathanson, John Allen Moderators: Ernst Kuipers, Richard Saad

10:30 am • AASLD Research Forum S405 Tuesday, May 9, 2017 Antiviral therapy is under-utilized but associated with improved survival across tumor and liver disease stages and cancer 8:00 – 9:30 am • AGA Committee Sponsored Symposium S102d therapies in HBV-related hepatocellular carcinoma (HCC): Results Tales from the front lines: How GI practices are using quality of a multicenter United States–Asia cohort of 2307 patients measurement to drive improvement Vincent Chen, Ming-Lun Yeh, An Le, Peggy Tsai, Mijung Jun, Waqar Saeed, Hyo Young Lee, Pauline Nguyen, Nathan Kim, Chia-Yen Dai, Jee-Fu Huang, Moderators: Megan Adams, Ziad Gellad Chung-Feng Huang, Wan-Long Chuang, Dae Won Jun, Young-Suk Lim, Ming- Lun Yu, Mindie Nguyen 8:00 – 9:30 am • AGA Distinguished Abstract Plenary S104 Esophageal, Gastric & Duodenal Disorders 10:30 am • AGA Research Symposium S105a The Best of Barrett’s, EOE, GERD, H. pylori Menin-MLL inhibitor MI-503 suppresses plasma gastrin in a Moderators: John Kao, Michael Vaezi mouse model of hypergastrinemia Sinju Sundaresan, Michael Hayes, Jolanta Grembecka, Juanita Merchant 8:00 am • AGA Committee Sponsored Symposium S102d Tales from the front lines: How GI practices are using quality measurement to 10:45 am • AASLD Research Forum S405 drive improvement Significantly lower rates of cirrhosis and lower long-term Setting the stage: The importance of quality measures in survival in cryptogenic hepatocellular carcinoma (HCC) driving improvement in GI compared to viral etiologies: Results of a multi-center John Allen international cohort Tomi Jun, Ju Dong Yang, Ming-Lun Yeh, Vincent Chen, Pauline Nguyen, Minh Chung, Nasra H. Giama, Chung-Feng Huang, Chia-Yeh Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lun Yu, Lewis R. Roberts, Mindie H. Nguyen continued next page

22 The GI Digest Spring 2017 Daily Schedule

Tuesday, May 9, 2017 Tuesday, May 9, 2017

10:54 am • AGA Research Forum S503 3:15 pm • AASLD Research Forum S403a Efficacy of high-dose dual therapy versus bismuth-containing They do hurt more: A nationwide study of falls and injury quadruple therapy for first-line treatment of Helicobacter pylori among patients with cirrhosis infection and an interim report of multi-center, randomized Ghideon Ezaz, Elliot Tapper control study Chi-Tan Hu, Chien-Chih Tung, Chun-Jung Lin, I-Nan Kuo, Bor-Ru Lin, Hong-Long 4:00 pm • ASGE Clinical Symposium S402 Wang, Jin-De Chen, Mu-Liang Cheng, Chia-Tung Shun, Huei-Mi Li, Jui-Sheng ASGE/Chinese Society of Gastroenterology (CSGE) International Symposium Hung, Wei-Yi Lei, Ming Jium Shieh, Jau-Min Wong, John Kao, Jyh-Chin Yang Management of anti-thrombotics in elective and emergency 10:54 am • ASGE Clinical Symposium E350 endoscopy Imaging: The Next Generation of Optical Diagnostics Michelle Anderson

In vivo molecular imaging 5:00 pm • AGA Research Forum S101b Thomas Wang PGE2 produced by mast cells is critical to induce visceral 11:00 am • AGA Research Forum S101a hypersensitivity in IBS Bile acids regulate intestinal paneth cell functions and Gintautas Grabauskas, Xiaoyin Wu, Kim Turgeon, Chung Owyang contribute to gut dysbiosis induced by high fat feeding Hui Zhou, Merritt Gillilland, Jun Gao, Shi-Yi Zhou, Guanpo Zhang, Chung Owyang

2:00 – 3:30 pm • AASLD Research Forum S403a Health-Care in the Hospital and Clinic for Chronic Liver Disease Moderators: Kiran Bambha, John Magee

2:00 – 4:00 pm • DDW Clincal Symposium S100c The Best of DDW 2017 Moderators: Steven Edmundowicz, Grace Elta

2:36 pm • AGA Research Forum S106 Gastrointestinal motility and luminal pH influence in vivo dissolution and systemic absorption of drug product in human gastrointestinal tract under fed and fasted conditions Mark Koenigsknecht, Jason Baker, Ann F. Fioritto, Yasuhiro Tsume, Bo Wen, Joseph Dickens, Alex Yu, Jeffery Wysocki, Kerby Shedden, Barry Bleske, Allen Lee, William Hasler, Gordon Amidon, Duxin Sun

3:00 pm • AASLD Topic Forum S405 Serum concentrations of cartilage oligomeric matrix protein are correlated with the presence of advanced hepatic fibrosis in untreated hepatitis C Ryan Stidham, Akbar Waljee, Peter Higgins, Anna Lok

3:00 pm • AGA Research Forum S102d Chronic stress-associated abdominal pain: Glucocorticoid receptor mediates interleukin 6–induced down-regulation of epithelial tight junction protein occludin and enhanced visceral pain Ye Zong, Shengtao Zhu, John Wiley, Shuangsong Hong

Spring 2017 The GI Digest 23 Poster Sessions

Saturday, May 6, 2017 9:30 am – 4:00 pm

Sa1016 Vanessa Cardenas, Nikhil Mankuzhy, Lili Zhao, Bailey Anderson, Kevin Frank, Maclovio Lopez, Robert Fontana, The right idea in the wrong patient: A national survey of Rajen Mody, Frank DiPaola internists’ attitudes towards stopping PPIs Jacob Kurlander, Mark Kolbe, Akbar Waljee, Brian Zikmund- Sa1618 Fisher, Sandeep Vijan, Arlene Weissman, James Scheiman, Joel Rubenstein, Sameer Saini Randomized controlled trial to assess the efficacy & safety of caraway oil/l-menthol plus usual Sa1028 care polypharmacy vs. placebo plus usual care polypharmacy for functional dyspepsia Patients are willing to repeat colonoscopy at a short interval when bowel preparation quality is suboptimal William Chey, Brian Lacy, Brooks Cash, Michael Epstein, Syed Shah Jennifer Maratt, Stacy Menees, Marc Piper, Brian Zikmund- Fisher, Sameer Saini Sa1619

Sa1074 Efficacy of caraway oil/l-menthol plus usual care vs placebo plus usual care, in functional dyspepsia A simulation-based mastery learning model of patients with post-prandial distress (PDS) or epigastric percutaneous endoscopic gastrostomy tube placement pain (EPS) syndromes: Results from a US RCT improves gastroenterology fellow procedural attitudes William Chey, Brian Lacy, Brooks Cash, Michael Epstein, Syed Andrew Wright, Rafat Rizk, Anoop Prabhu Shah

Sa1088 Sa1620 Training in small bowel endoscopy: Results of a national A caraway oil/menthol combination improves survey of GI fellowship programs functional dyspepsia (FD) symptoms within the first 24 Andrew Read, Michael Rice, Hari Conjeevaram, Sameer hours: Results of a randomized controlled trial, which Saini allowed usual FD treatments Brian Lacy, William Chey, Brooks Cash, Michael Epstein, Syed Sa1131 Shah How is OIC diagnosed and managed? Insights from a virtual patient simulation Sa1623 Jovana Lubarda, Martin Warters, Piyali Chatterjee, Brooks Cash, Sex differences in fecal incontinence: Results from a US William Chey population-based study Stacy Menees, Christopher Almario, Brennan Spiegel, Sa1241 William Chey High-fat feeding enhances stemness of intestinal progenitors and stimulates epithelial proliferation via Sa1624 upregulation of R-spondin 3 and its receptors LGR4 and 5 Clinical and economic impact of a multidisciplinary Ji-Yao Li, Xiaoyin Wu, Merritt Gillilland, Shi-Yi Zhou, Chung management program in patients with fecal Owyang incontinence: Do symptomatic improvements in fecal incontinence decrease personal costs? Sa1570 Stacy Menees, Kenya Jackson, Xiao Xu, Dee Fenner Liver injury in children undergoing treatment for cancer: Analysis of a large single-center cohort

24 The GI Digest Spring 2017 Poster Sessions

Saturday, May 6, 2017 9:30 am – 4:00 pm Saturday, May 6, 2017 9:30 am – 4:00 pm

Sa1638 Sa1953 A systematic review and meta-analysis to determine Vedolizumab persistence and tolerability in special whether balloon expulsion testing might be an populations is similar to other IBD users appropriate initial office-based test for dyssynergic Joshua Turkeltaub, Akbar Waljee, Shail Govani, Julajak defecation Limsrivilai, Peter Higgins, Ryan Stidham Eric Shah, Jeremy Farida, William Chey Sa1997 Sa1662 Vitamin D deficiency in gastroparesis and chronic In ineffective esophageal motility, failed swallows are unexplained nausea and vomiting: Relationship with more functionally relevant than weak swallows gastric emptying and symptoms Anand Jain, Jason Baker, Joan Chen Pankaj Pasricha, Mark Van Natta, Richard McCallum, Linda Anh Nguyen, Irene Sarosiek, James Tonascia, Thomas Abell, Sa1813 William Hasler, Ellen Stein, John Clarke, Madhusudan Grover, Gianrico Farrugia, William Snape, Kenneth Koch, MSI-L/EMAST, a poor outcome biomarker for colorectal Frank Hamilton, Henry Parkman cancer patients, is present in young ulcerative colitis patients that require high doses of anti-inflammatory agents, and shows clonality Sunday, May 7, 2017 9:30 am – 4:00 pm Koji Munakata, Minoru Koi, Takahito Kitajima, Stephanie Tseng-Rogenski, Mamoru Uemura, Tsunekazu Mizushima, Yuji Toiyama, Masaki Mori, John Carethers Su1005 Location of healthcare delivery (county vs tertiary care Sa1864 based centers) may influence disease related outcomes Intra-abdominal abscess size and the use of in African-American patients with inflammatory bowel percutaneous drainage are not associated with disease (IBD) avoidance of surgery in Crohn’s disease Zachary Spiritos, Kevin Luk, Evan Brady, Amar Mandalia, Daniel Perl, Shail Govani, Akbar Waljee, Peter Higgins, Angela Ward, Saurabh Chawla, Heba Iskander, Tanvi Dhere Ryan Stidham Su1035 Sa1946 Meta-analysis of missed high grade dysplasia or cancer Machine learning models at week 6 of vedolizumab in patients with Barrett’s esophagus diagnosed with therapy for inflammatory Crohn’s disease can accurately low grade dysplasia predict week 52 corticosteroid free biologic remission Joel Rubenstein, Akbar Waljee, Jacques Bergman, Michael Akbar Waljee, Boang Liu, Kay Sauder, Ji Zhu, Shail Govani, Vieth, Sachin Wani Ryan Stidham, Peter Higgins Su1278 Sa1950 Predictors of short-term and long-term resolution Vedolizumab is safe and effective for IBD, but has no effect of symptomatic walled-off necrosis managed by on liver biochemistry in patients with concurrent PSC endoscopic therapy Britt Christensen, Dejan Micic, Peter Gibson, Samrath Singh, Tossapol Kerdsirichairat, Richard Kwon, Stuart Amateau, Emanuelle Bellaguarda, Paul Corsello, John Gaetano, Jami Sidney Walker, Mustafa Arain, J. Shawn Mallery, Rajeev Attam, Kinnucan, Vijaya Rao, Shilpa Reddy, Andres Yarur, David Gregory Beilman, Guru Trikudanathan, Martin Freeman Rubin, Joel Pekow

Spring 2017 The GI Digest 25 Poster Sessions

Sunday, May 7, 2017 9:30 am – 4:00 pm

Su1298 Su1548 Plastic stents are comparable to lumen apposing metal Intragastric meal distribution (IMD) during routine stents in the management of pancreatic pseudocysts: a gastric emptying scintigraphy (GES) to better relate large international multicenter study symptoms of gastroparesis to abnormal gastric motility Juliana Yang, Yen-I Chen, Shai Friedland, Ian Holmes, Ryan Law, Perry Orthey, Mark Van Natta, Alan Maurer, Daohai Yu, Amy Hosmer, Tyler Stevens, Matheus Franco, Sunguk Jang, Frederick Ramsey, Jesus Diaz, Paige Clark, Andrei Iagaru, Rishi Pawa, Nihar Mathur, Divyesh Sejpal, Sumant Inamdar, William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Arvind Trindade, Jose Nieto, Tyler Berzin, Michael DeSimone, Nguyen, William Snape, Thomas Abell, Richard McCallum, Christopher DiMaio, Sanchit Gupta, Patrick Yachimski, Andrea Irene Sarosiek, John Clarke, Laura Miriel, James Tonascia, Anderloni, Todd Baron, Theodore James, Laith Jamil, Mel Frank Hamilton, Pankaj Pasricha, Henry Parkman Ona, Nuha Alammar, Eugenie Shieh, Majidah Bukhari, Olaya Isabella Brewer Gutierrez, Omid Sanaei, Lea Fayad, Saowonee Su1550 Ngamruengphong, Vivek Kumbhari, Vikesh Singh, Alessandro Differences between obese and non-obese patients Repici, Mouen Khashab with idiopathic gastroparesis Su1394 Henry Parkman, Erin Hallinan, William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Nguyen, William Snape, Prevalence of pre-operative hyperbilirubinemia and Thomas Abell, Richard McCallum, Irene Sarosiek, Laura Miriel, predictors of choledocholithiasis in patients with acute James Tonascia, Frank Hamilton, Pankaj Pasricha calculus cholecystitis Phillip Chisholm, Arpan Patel, Shail Govani, Anoop Prabhu Su1554 Relation of opiate use to clinical manifestations, quality Su1521 of life, and resource use in gastroparesis: Impact of Symptom and anorectal manometry characteristics of μ-opioid agonist potency constipated patients with fibromyalgia William Hasler, Laura Wilson, Linda Anh Nguyen, William Jason Baker, Richard Saad, Stacy Menees, Shanti Eswaran, Snape, Henry Parkman, Thomas Abell, Kenneth Koch, Richard Allen Lee, William Chey, Borko Nojkov McCallum, Pankaj Pasricha, Irene Sarosiek, Gianrico Farrugia, Madhusudan Grover, Linda Lee, Laura Miriel, James Tonascia, Su1532 Frank Hamilton Indirect treatment comparison: Placebo-adjusted results Su1573 from phase 3 trials of two GC-C agonists in patients with chronic idiopathic constipation – linaclotide and Patients are uncomfortable with the use of risk plecanatide calculators to guide decisions about colorectal cancer Phillip Schoenfeld, An-Chen Fu, Courtney Walls, David Reasner, screening: Results of a large regional survey Kenneth Tripp, Robyn Carson, Jessica Abel, Douglas Taylor Marc Piper, Jennifer Maratt, Anna Tavakkoli, Valbona Metko, Akbar Waljee, Brian Zikmund-Fisher, Sameer Saini Su1539 Su1574 Impact of age and gender to severity of constipation- related symptoms and quality of life indices in patients Understanding why older patients continue low-value with chronic idiopathic constipation colorectal cancer screening: A systematic review of Borko Nojkov, Jason Baker, Allen Lee, Shanti Eswaran, quantitative, qualitative, and mixed-methods studies Stacy Menees, Richard Saad, William Chey Marc Piper, Jennifer Maratt, Akbar Waljee, Carmen Lewis, Sameer Saini

26 The GI Digest Spring 2017 Poster Sessions

Sunday, May 7, 2017 9:30 am – 4:00 pm Monday, May 8, 2017 9:30 am – 4:00 pm

Su1771 Mo1140 Prevalence of germline mutations in individuals with MiR-143-3p induced by Helicobacter infection inhibits multiple colon polyps TGF-β expression and mediates inflammatory dendritic Shreya Sengupta, Kelly Watkins, Erika Koeppe, Monica Marvin, cell phenotype Elena Stoffel Jiping Zeng, Lixiang Wang, Min Zhang, Mohamad El-Zaatari, Helmut Grasberger, John Kao Su1775 A minority of patients with colorectal cancer (CRC) Mo1240 are appropriately screened for Lynch syndrome in a dual center study of two large academically affiliated Lumen apposing stents are superior to plastic stents in Veterans Affairs Medical Centers (VAMCs) the management of pancreatic walled-off necrosis: A large international multicenter study Chetan Mittal, Duyen Dang, Anna Dang, Elena Stoffel, Dennis Ahnen, Swati Patel Yen-I Chen, Juliana Yang, Shai Friedland, Ian Holmes, Ryan Law, Amy Hosmer, Tyler Stevens, Matheus Franco, Sunguk Jang, Su1884 Rishi Pawa, Nihar Mathur, Divyesh Sejpal, Sumant Inamdar, Autoimmune paradoxical reactions in inflammatory Arvind Trindade, Jose Nieto, Tyler Berzin, Michael DeSimone, bowel diseases longitudinal (APRIL) cohort: Christopher DiMaio, Sanchit Gupta, Patrick Yachimski, Andrea Methodology and initial results Anderloni, Todd Baron, Theodore James, Laith Jamil, Mel Ona, Nuha Alammar, Eugenie Shieh, Majidah Bukhari, Olaya Millie Long, Raymond Cross, Sumona Saha, Anita Afzali, Isabella Brewer Gutierrez, Omid Sanaei, Lea Fayad, Dongxun Peter Higgins, Christopher Martin, Hans Herfarth Zhou, Saowonee Ngamruengphong, Vivek Kumbhari, Vikesh Singh, Alessandro Repici, Mouen Khashab Su1925 Long-term safety and tolerability of oral tofacitinib in Mo1314 patients with Crohn’s disease: Results from a phase 2 open-label 48-week extension study Patient and disease characteristics associated with presence of diabetes mellitus in adults with chronic Julian Panés, Geert D’Haens, Peter Higgins, Linda Mele, pancreatitis in the U.S. Michele Moscariello, Gary Chan, Wenjin Wang, Wojciech Niezychowski, Chinyu Su, Eric Maller Melena Bellin, David Whitcomb, Judah Abberbock, Stuart Sherman, Bimaljit Sandhu, Timothy Gardner, Michelle Anderson, Su1943 Michele Lewis, Samer Alkaade, Vikesh Singh, John Baillie, Gastrointestinal infectious agents detected by Peter Banks, Darwin Conwell, Gregory Cote, Nalini Guda, BioFire FilmArray GI PCR Panel stool testing in active Thiruvengadam Muniraj, Gong Tang, Randall Brand, Andres inflammatory bowel disease are common and are Gelrud, Stephen Amann, Chris Forsmark, C. Mel Wilcox, Adam associated with a more benign course of IBD Slivka, Dhiraj Yadav Julajak Limsrivilai, Ryan Stidham, Akbar Waljee, Shail Mo1479 Govani, Krishna Rao, Brian Gutermuth, Alexandra Brown, Emily Briggs, Peter Higgins Elevated intrabolus pressure (IBP) as a marker of structural esophagogastric junction (EGJ) processes Su1994 when integrated relaxation pressure (IRP) is normal Probiotic-mediated protection against chronic water- on esophageal high resolution manometry (HRM): A avoidance stress enteritis in mice is associated with validation study lamina propria plasmacytoid dendritic cell infiltration Farhan Quader, Chanakyaram Reddy, Amit Patel, C. Prakash Chun-Chia Chen, Bryan Chow, Yundong Sun, Min Zhang, Gyawali Mohamad El-Zaatari, Helmut Grasberger, John Kao

Spring 2017 The GI Digest 27 Poster Sessions

Monday, May 8, 2017 9:30 am – 4:00 pm Monday, May 8, 2017 9:30 am – 4:00 pm

Mo1545 Mo1862 Patients with IBS-C report more severe, bothersome, Targeted loss of forkhead box A1 (FOXA1) transcription frequent and diffuse abdominal pain vs. IBS-D: Results factor sites within the hypoxia inducible factor 3A of a nationwide population-based study (HIF3A) locus from liver metastasis (LM) derived from Eric Shah, Christopher Almario, Brennan Spiegel, William Chey MSI-L/EMAST primary colorectal cancer (CRC) Alexander W. Worix, Minoru Koi, Takahito Kitajima, Chan Mo1546 Choi, Hyeong-Rok Kim, Yuji Toiyama, Masato Kusunoki, John Assessing long-term persistence with pharmacotherapy Carethers for constipation-predominant irritable bowel syndrome and functional constipation in clinical practice: A retrospective cohort analysis Eric Shah, William Chey, Ryan Stidham Tuesday, May 9, 2017 9:30 am – 4:00 pm

Mo1562 Tu1063 The low FODMAP diet is equally efficacious in IBS-D Despite high interest in telemedicine video visits for patients with and without baseline anxiety: A post-hoc analysis from a US randomized, controlled trial maintenance IBD care, few patients are willing to pay more for increased convenience Shanti Eswaran, William Chey, Kenya Jackson, Theresa Han- Markey Jack Bevins, Shail Govani, Akbar Waljee, Peter Higgins, Ryan Stidham Mo1666 Tu1119 Differences in demographic and symptom-related characteristics among patients with irritable bowel Systematic review and meta-regressions: Management syndrome with constipation (IBS-C) and chronic of eosinophilic esophagitis requires histologic idiopathic constipation (CIC): Results from the CONTOR assessment Study Joy Chang, Raymond Yeow, Akbar Waljee, Joel Rubenstein Jessica Abel, Douglas Taylor, Jalpa Doshi, Carolyn Martin, Alyssa Goolsby Hunter, Breanna Essoi, Paul Buzinec, Robyn Tu1415 Carson, David Reasner, William Chey An international multicenter study on digital single operator cholangioscopy for the management of Mo1718 difficult bile duct stones in 271 patients The systemic inflammatory response to Clostridium difficile infection (CDI) in patients with ulcerative colitis Olaya Isabella Brewer Gutierrez, Saowonee Ngamruengphong, Isaac Raijman, Richard Sturgess, Divyesh Sejpal, Stuart Julajak Limsrivilai, Krishna Rao, Ryan Stidham, Shail Govani, Sherman, Raj Shah, Richard Kwon, James Buxbaum, Claudio Akbar Waljee, Andrew Reinink, Laura Johnson, Emily Briggs, Zulli, Wahid Wassef, Douglas Adler, Daniel Mullady, Andrew Peter Higgins Wang, Kumar Krishnan, Vivek Kaul, Demetrios Tzimas, Christopher DiMaio, Sammy Ho, Bret Petersen, George Mo1792 Webster, Moon Sung Lee, Yen-I Chen, Laura Dwyer, Sumant IBD patients with severe disease are at greater risk of Inamdar, Sheryl Lynch, Augustin Attwell, Amy Hosmer, Amar developing pneumonia prior to IBD diagnosis Manvar, Christopher Ko, Attilio Maurano , Avik Sarkar, Linda Taylor, Vladimir Kushnir, Jessica Harris, Sanchit Gupta, John Martin Gregory, Matthew Ciorba, Wyndy Wiitala, Ryan Stidham, Martin, Noor Bekkali, Yun Nah Lee, Daniel Strand, Ali Raza, Peter Higgins, Jason Hou, Linda Feagins, Shail Govani, Akbar Waljee

28 The GI Digest Spring 2017 Poster Sessions

Tuesday, May 9, 2017 9:30 am – 4:00 pm

Majidah Bukhari, Omid Sanaei, Shivangi Kothari, Martin Tu1872 • Poster of Distinction Gregory, Asad Ullah, Truptesh Kothari, Christopher Gostout, Inhibition of Axl signaling by BGB324 reduces Mark Topazian, Dushant Uppal, Arvind Trindade, Juan Carlos Bucobo, Nikhil Kumta, Vanessa Patrick, Mouen Khashab fibrogenesis in human intestinal cells and human intestinal organoids Tu1499 Calen Steiner, Eva Rodansky, Laura Johnson, Sha Huang, Use of a double-pigtail stent to prevent migration Jason Spence, Peter Higgins of fully covered metal stents in biliary strictures: A Tu1874 retrospective analysis Use of second harmonic generation (SHG) and 2-photon Arpan Patel, Phillip Chisholm, Ryan Law, Erik-Jan Wamsteker, Grace Elta, Richard Kwon, Anoop Prabhu, emission imaging to quantify and describe the structure James Scheiman, Michelle Anderson of tissue fibrosis in the rat TNBS intestinal fibrosis model Laura Johnson, David Moons, Li Chen, Mathieu Petitjean, Tu1520 Peter Higgins, Ryan Stidham Access to care and cirrhosis outcomes: A nationwide Tu1962 analysis of the Truven MarketScan employer-sponsored insurance database Novel peptide probe targets GPC3 overexpression in vivo Jessica Mellinger, Kerby Shedden, Elliot Tapper, Anna Lok, in hepatocellular carcinoma Michael Volk Quan Zhou, Zhao Li, Juan Zhou, Xiyu Duan, Rork Kuick, Thomas Wang Tu1554 Tu1995 Prevalence and new starts of proton pump inhibitors (PPI) in patients presenting with variceal bleeding: A 5 Claudin-1 and ErbB2 are potential biomarkers for biliary year, multi-center US experience intraepithelial neoplasia, a premalignant precursor of Elliot Tapper, Jennifer Friderici, Zachary Borman, Jacob cholangiocarcinoma Alexander, Alan Bonder, Sheryl Ramdass, Rony Ghaoui Matthew Sturm, Bishnu Joshi, Scott Owens, Thomas Wang

Tu1655 Tu2011 Gastrin stimulates nuclear export of menin and Transcutaneous shear wave elastography ultrasound proteasomal degradation in enteric glial cells can measure longitudinally worsening intestinal fibrosis Sinju Sundaresan, Michael Hayes, Lin Ding, Juanita Merchant in a rat model of Crohn’s disease Peter Higgins, Laura Johnson, Porzondek Kelli, Jonathan Tu1664 Rubin, Jonathan Dillman Gastric emptying and symptoms of gastroparesis: Tu2031 Specific symptoms correlating to severity of gastric retention Targeted delivery of linaclotide to specific areas of the Henry Parkman, Katherine Yates, Alan Maurer, William Hasler, intestine affects clinical efficacy in patients with irritable Gianrico Farrugia, Madhusudan Grover, Kenneth Koch, Linda bowel syndrome with constipation (IBS-C) Anh Nguyen, William Snape, Thomas Abell, Richard McCallum, William Chey, Paul Chamberlin, Wiesław Bochenek, Kenneth Irene Sarosiek, James Tonascia, Pankaj Pasricha, Frank Hamilton Tripp, Carolyn Higgins, Nicholas Omniewski, Susan Fox, Michael Hall, Ahmad Hashash, Matthew Miller, Christopher O’Dea, Mark Currie

Spring 2017 The GI Digest 29 Index

Faculty Faculty

Page Page ADAMS, Megan...... 9, 10, 16, 19, 20, 21, 22 RIEHL, Megan...... 13, 21 ALLEN, John...... 10, 15, 16, 17, 18, 20, 21, 22 RIZK, Rafat...... 24 ANDERSON, Michelle...... 12, 13, 16, 17, 18, 19, 20, 21, 23, 27, 29 RUBENSTEIN, Joel...... 1, 10, 11, 16, 19, 21, 22, 24, 25, 28 BISHU, Shrinivas...... 6, 11, 19 SAAD, Rick...... 10, 22, 26 CARETHERS, John...... 1, 3, 11, 18, 25, 28 SAINI, Sameer...... 11, 12, 19, 20, 24, 26 CHEN, Joan...... 25 SAMUELSON, Linda...... 1, 8, 10, 15, 19, 20 CHEY, Bill...... 11, 12, 13, 15, 17, 18, 19, 21, 22, 24, 25, 26, 28, 29 SCHEIMAN, Jim...... 12, 20, 24, 29 CONJEEVARAM, Hari...... 1, 4, 24 SCHOENFELD, Phil...... 26 DANG, Duyen...... 27 SHAH, Yatrik...... 9, 11, 18, 19

DiMAGNO, Matt...... 9, 17, 18 SPENCE, Jason...... 13, 21, 29 ELTA, Grace...... 1, 10, 11, 15, 16, 17, 18, 19, 22, 23, 29 STIDHAM, Ryan...... 10, 11, 14, 18, 19, 23, 25, 27, 28, 29 EL-ZAATARI, Mo...... 9, 11, 18, 19, 27 STOFFEL, Elena...... 16, 21, 27 ESWARAN, Shanti...... 9, 12, 13, 19, 22, 26, 28 SU, Grace...... 13, 21 FONTANA, Bob...... 9, 10, 18, 21, 24 TAPPER, Elliot...... 14, 23, 29 GILLILLAND, Merritt...... 14, 23, 24 TODISCO, Andrea...... 8, 20 GOVANI, Shail...... 11, 18, 19, 25, 26, 27, 28 TSENG-ROGENSKI, Stephanie...... 11, 18, 25 GRABAUSKAS, Gintas...... 14, 23 TURGEON, Kim...... 14, 23 GUMUCIO, Deb...... 13, 21 VOLK, Michael...... 29 HASLER, Bill...... 12, 13, 14, 20, 21, 23, 25, 26, 29 WALJEE, Akbar...... 9, 10, 11, 14, 18, 19, 21, 23, 24, 25, 26, 27, 28 HIGGINS, Peter...... 9, 10, 11, 13, 14, 18, 19, 21, 22, 23, 25, 27, 28, 29 WAMSTEKER, Erik-Jan...... 9, 18, 29 HOSMER, Amy...... 26, 27, 28 WANG, Tom...... 11, 16, 19, 23, 29 HONG, Shuangsong...... 14, 23 WILEY, John...... 1, 10, 14, 20, 23 KAMADA, Nobu...... 11, 19 ZHOU, Juan...... 29 KAO, John...... 1, 9, 10, 11, 14, 16, 18, 19, 22, 23, 27 ZHOU, Shi-Yi...... 14, 23, 24 KINNUCAN, Jami...... 15, 20, 25 KOI, Minoru...... 11, 18, 25, 28 Fellows KURLANDER, Jacob...... 10, 12, 20, 24 Page KWON, Richard...... 13, 21, 25, 28 CHANG, Joy...... 28 LAW, Ryan...... 6, 26, 27, 29 CHEN, Vincent...... 14, 22 LEE, Allen...... 14, 23, 26 CHISHOLM, Phillip...... 26, 29 LI, Ji-Yao...... 13, 21, 24 CORSELLO, Paul...... 25 LOK, Anna...... 8, 10, 13, 14, 20, 21, 23, 29 JAIN, Anand...... 25 MAGEE, John...... 10, 23 KERDSIRICHAIRAT, Tos...... 6, 13, 14, 21, 22, 25 MELLINGER, Jessica...... 29 MANDALIA, Amar...... 25 MENEES, Stacy...... 24, 26 MARATT, Jennifer...... 24, 26 MERCHANT, Juanita...... 1, 5, 9, 10, 11, 12, 16, 18, 19, 20, 22, 29 PATEL, Arpan...... 26, 29 MUZA-MOONS, Michelle...... 13, 21 PIPER, Marc...... 24, 26 NOJKOV, Borko...... 26 REDDY, Shan...... 27 OMARY, Bishr...... SENGUPTA, Shreya...... 27 OWYANG, Chung...... 13, 14, 21, 23, 24 SHAH, Eric...... 12, 21, 25, 28 PRABHU, Anoop...... 24, 26, 29 STURM, Matthew...... 29 READ, Andrew...... 24 TAVAKKOLI, Anna...... 11, 19, 26 RICE, Michael...... 9, 18, 24 WRIGHT, Andrew...... 24

30 The GI Digest Spring 2017