DOCSLIB.ORG

Pneumocystis Canis Pneumonia in Dogs

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Pneumocystis Canis Pneumonia in Dogs Under the Microscope Pneumocystis canis pneumonia in dogs Elizabeth RalphA, George ReppasB, Catriona HallidayC, Mark KrockenbergerD and Richard MalikE,F AAnimal Referral Hospital, 250 Parramatta Road, Homebush West, NSW 2140, Australia BVetnostics, 60 Waterloo Road, North Ryde, NSW 2113, Australia CCentre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, Westmead, NSW 2145, Australia DFaculty of Veterinary Science, The University of Sydney, NSW 2006, Australia ECentre for Veterinary Education, The University of Sydney, NSW 2006, Australia FCorresponding author. Email: [email protected] Pneumocystis canis is a potential cause of life-threatening to develop fast molecular techniques to diagnose P. canis† interstitial fungal pneumonia in dogs. It is seen almost pneumonia (PCP)7,9 and to determine the underlying exclusively in two canine breeds, miniature Dachshunds immune defect in over-represented breeds through the and Cavalier King Charles Spaniels (CKCS)1. Historically, rapidly advancing field of canine genomics10. Australian veterinarians had a key role in the documentation Pneumocystis spp. are ubiquitous commensals of the respiratory of this entity and its conspicuous breed associations2–4. tract of many mammalian species, including dogs1. This group of Affected Dachshunds and CKCS are likely to have an inher- organisms has the potential to cause life-threatening pneumonia in a ited immunodeficiency that predisposes them to infection wide range of mammals, including rats, pigs, horses and goats1. with this commensal organism of the respiratory tract and P. jirovecii has the same pathogenic potential in people1. Airborne pharynx1,2,5,6. A high index of suspicion is required to make droplet transmission from subclinically affected normal dogs, often a timely diagnosis and save affected patients, as these dogs transmitted from bitch to pup soon after birth, is suspected of being cope poorly with anaesthesia and other measures to procure the means for transmission1. PCP results from the effects of masses the specimens required to make a definitive diagnosis. of organisms within the alveolar spaces, combined with the asso- Bordetella bronchiseptica Possible co-infection with must – ciated inflammatory response of the host1 6. be considered when determining antimicrobial strategies. Affected dogs occasionally have a previous or concurrent Historically, most canine cases had been reported in young (less – history of generalised demodicosis5,7,8. With early interven- than one-year-old) miniature Dachshunds1 3,6,11. The first docu- tion, affected dogs can be saved, although some require life- mentation of this entity was provided in a paper from the University long therapy to prevent recurrence. The future challenge is of Sydney (UoS) by Farrow and colleagues2, although a brilliant † The literature refers to Pneumocystis carinii infection of dogs, although recent taxonomic developments suggest this name should be probably restricted to organisms that infect rats. One conference Abstract suggests the name Pneumocystis canis9, although Pneumocystis special form canis may be a safer term in the interim. For the purposes of this article we have used the term P. canis for simplicity. MICROBIOLOGY AUSTRALIA * MAY 2015 10.1071/MA15026 79 Under the Microscope (a)(b) Figure 1. (a) Dorsoventral thoracic radiograph from a one-year-old Cavalier King Charles spaniel with pneumocystosis, revealing a patchy, diffuse, interstitial pattern in all lung fields. (b) Right lateral thoracic radiograph of the same dog reveals a diffuse interstitial to alveolar pattern, especially in the dorsocaudal lung fields. immunoparasitologist at McMaster Laboratory (Robert J. Love) pro- this was common in the Camden district in the 1970s. A test was vided key immunologic insights.z The disease in Dachshunds was developed for this genetic disease of horses, and nowadays the characterised further by South African veterinarians, with Lobetti condition is hardly encountered, a cogent example of genetic and colleagues adapting human treatment strategies to successfully counselling and preventative veterinary medicine16. manage their canine cases1,11. The best radiological description of In dogs, the nature of the immune defect in Dachshunds and PCP was provided by Kirberger12, although this has been comple- Cavaliers has not been determined at the molecular level. Poor mented by recent advances in imaging such as digital radiology and lymphocyte stimulation (despite normal lymphocyte numbers computed tomography (CT). Although PCP continues to be seen in in peripheral blood) has been documented in miniature Dachs- Dachshunds in South Africa and the USA, the great majority of cases hunds1,2. IgA, IgM and IgG concentrations are subnormal in affected encountered in Australia over the past 20 years have been in adult members of this breed6. Subsequent assessment of CKCS with CKCS, the first detailed report being provided by Paul Canfield pneumocystosis also reveals immunoglobulin deficiencies and de- and colleagues from UoS in 19934. This breed preponderance was creased lymphocyte function5,7. These immunodeficiencies persist then detected in the UK5,13 and subsequently Europe, the USA after resolution of the infection with effective antimicrobial therapy. and Japan7. ‘Cavaliers’ tend to get the disease as young adult Studies of the involvement of adaptive cell-mediated immunity and dogs4,5,13. There may be antecedent or concurrent footprints of innate immunity (including the potential involvement of Toll-like immune deficiency, such as generalised demodicosis5,8. receptors) would be sensible but have not yet been performed. In people, the disease is best known as a complication of HIV/AIDS, Most dogs with PCP present with respiratory signs, including dys- although it is also seen in transplant recipients and other patients pnoea, tachypnoea, increased breath sounds on thoracic ausculta- receiving immunosuppressive drug regimens. A very well charac- tion or cyanotic mucous membranes. The presence of a cough is terised case cluster in Australia that closed a transplant ward at variable, and this sign is frequently absent. Duration of signs prior to Westmead Hospital was reported by Sharon Chen, Wieland Meyer presentation for veterinary attention can be as long as four weeks1–4. and their ANZMIG colleagues14. In Arabian horses and related Haematologic and serum biochemical abnormalities are non-spe- breeds, foals with autosomal recessive severe combined immuno- cific1. Thoracic radiographs reveal diffuse, bilaterally symmetrically deficiency syndrome (analogous to the like-named SCID condition increased radiodensity of the pulmonary parenchyma, classically of men and mice) typically died of PCP in the neonatal period15, and described as a miliary-interstitial to alveolar pattern (Figure 1)1,12,17. z The first report of PCP pneumonia in dogs was actually from Germany in 1955. The patient was a nine-week-old sheepdog pup with Pneumocystis forms in its lungs, hilar lymph nodes and myocardium. Sedlmeier, H. and Dahme, E. (1955) Pneumocystis carinii-Infektionbiem Hund. Zentralbl. Allg. Path. 93, 150–155. 80 MICROBIOLOGY AUSTRALIA * MAY 2015 Under the Microscope Figure 3. A single cyst-like structure (red arrow) suspicious of Pneumocystis spp. ‘cyst’ seen on cytology from a one-year-old Cavalier King Charles Spaniel with pneumocystosis (Diff QuikÒ stain, Figure 2. Thoracic computer tomography scan in the same dog as oil immersion microscopy). Figure 1 reveals a marked, patchy, increased pulmonary opacity throughout all lung lobes with some peripheral consolidation. The Treatment includes appropriate antimicrobial therapy, using intra- ground-glass appearance of the lung parenchyma is quite characteristic of advanced PCP in the dog. venous trimethoprim sulfonamide combinations, and less com- monly nebulised pentamidine, along with appropriate supportive There is often radiological evidence of right-sided heart enlarge- care (e.g. supplementary oxygen, nebulisation, chest physiothera- ment and pulmonary hypertension, and this can be confirmed py). Long-term ventilation of affected dogs is challenging and echocardiographically4. Solitary opacities, cavitary lesions or a beyond the financial limits of most owners. There is no zoonotic non-symmetric radiographic changes are less commonly ob- potential for humans in close contact with a Pneumocystis infected served1,12. Severe long-standing cases may develop emphysema1. dogs, as the organisms in humans and dogs are distinct and no The CT findings in canine PCP are dramatic (Figure 2), providing a evidence of cross-species transmission has been documented. better appreciation of the lung pathology and disclosing regional lymphadenomegaly. As thoughtful and responsible veterinary physicians, we should be banking DNA from all dogs with confirmed and presumptive Diagnosis can be challenging in a veterinary context, with identifi- PCP. The most likely way to eliminate this condition is by harnessing cation of P. canis ‘cysts’ in bronchoalveolar lavage fluid (BAL) the power of canine genomics to detect any underlying genetic or transthoracic fine needle aspirates of lung generally being re- defect, utilising either a genome-wide association study or whole quired. Intact cysts are distinctive, being 5–10 mm in diameter and genome sequencing of ‘Trios’ of affected and closely related dogs10. containing 4–8 dark-staining intracystic bodies (2–3 mm in diameter; It is much better to try and prevent this severe mycosis
Load more

Recommended publications
  • COVID-19 Pneumonia: the Great Radiological Mimicker
    Duzgun et al. Insights Imaging (2020) 11:118 https://doi.org/10.1186/s13244-020-00933-z Insights into Imaging EDUCATIONAL REVIEW Open Access COVID-19 pneumonia: the great radiological mimicker Selin Ardali Duzgun* , Gamze Durhan, Figen Basaran Demirkazik, Meltem Gulsun Akpinar and Orhan Macit Ariyurek Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread worldwide since December 2019. Although the reference diagnostic test is a real-time reverse transcription-polymerase chain reaction (RT-PCR), chest-computed tomography (CT) has been frequently used in diagnosis because of the low sensitivity rates of RT-PCR. CT fndings of COVID-19 are well described in the literature and include predominantly peripheral, bilateral ground-glass opacities (GGOs), combination of GGOs with consolida- tions, and/or septal thickening creating a “crazy-paving” pattern. Longitudinal changes of typical CT fndings and less reported fndings (air bronchograms, CT halo sign, and reverse halo sign) may mimic a wide range of lung patholo- gies radiologically. Moreover, accompanying and underlying lung abnormalities may interfere with the CT fndings of COVID-19 pneumonia. The diseases that COVID-19 pneumonia may mimic can be broadly classifed as infectious or non-infectious diseases (pulmonary edema, hemorrhage, neoplasms, organizing pneumonia, pulmonary alveolar proteinosis, sarcoidosis, pulmonary infarction, interstitial lung diseases, and aspiration pneumonia). We summarize the imaging fndings of COVID-19 and the aforementioned lung pathologies that COVID-19 pneumonia may mimic. We also discuss the features that may aid in the diferential diagnosis, as the disease continues to spread and will be one of our main diferential diagnoses some time more.
    [Show full text]
  • Fungal Infection in the Lung
    CHAPTER Fungal Infection in the Lung 52 Udas Chandra Ghosh, Kaushik Hazra INTRODUCTION The following risk factors may predispose to develop Pneumonia is the leading infectious cause of death in fungal infections in the lungs 6 1, 2 developed countries . Though the fungal cause of 1. Acute leukemia or lymphoma during myeloablative pneumonia occupies a minor portion in the immune- chemotherapy competent patients, but it causes a major role in immune- deficient populations. 2. Bone marrow or peripheral blood stem cell transplantation Fungi may colonize body sites without producing disease or they may be a true pathogen, generating a broad variety 3. Solid organ transplantation on immunosuppressive of clinical syndromes. treatment Fungal infections of the lung are less common than 4. Prolonged corticosteroid therapy bacterial and viral infections and very difficult for 5. Acquired immunodeficiency syndrome diagnosis and treatment purposes. Their virulence varies from causing no symptoms to death. Out of more than 1 6. Prolonged neutropenia from various causes lakh species only few fungi cause human infection and 7. Congenital immune deficiency syndromes the most vulnerable organs are skin and lungs3, 4. 8. Postsplenectomy state RISK FACTORS 9. Genetic predisposition Workers or farmers with heavy exposure to bird, bat, or rodent droppings or other animal excreta in endemic EPIDEMIOLOGY OF FUNGAL PNEUMONIA areas are predisposed to any of the endemic fungal The incidences of invasive fungal infections have pneumonias, such as histoplasmosis, in which the increased during recent decades, largely because of the environmental exposure to avian or bat feces encourages increasing size of the population at risk. This population the growth of the organism.
    [Show full text]
  • Fungal Rhinosinusitis and Imaging Modalities
    Saudi Journal of Ophthalmology (2012) 26, 419–426 Oculoplastic Imaging Update Fungal rhinosinusitis and imaging modalities ⇑ Ian R. Gorovoy, MD a; Mia Kazanjian, MD b; Robert C. Kersten, MD a; H. Jane Kim, MD a; M. Reza Vagefi, MD a, Abstract This report provides an overview of fungal rhinosinusitis with a particular focus on acute fulminant invasive fungal sinusitis (AFIFS). Imaging modalities and findings that aid in diagnosis and surgical planning are reviewed with a pathophysiologic focus. In addition, the differential diagnosis based on imaging suggestive of AFIFS is considered. Keywords: Acute fulminant invasive fungal sinusitis, Fungal rhinosinusitis, Imaging, Computed tomography, Magnetic Resonance Imaging Ó 2012 Saudi Ophthalmological Society, King Saud University. All rights reserved. http://dx.doi.org/10.1016/j.sjopt.2012.08.009 Introduction individuals.6 It can be fatal over days and is characterized by invasion of the blood vessels with resulting tissue infarc- Fungal rhinosinusitis encompasses a wide spectrum of fun- tion. Unlike the other forms of fungal rhinosinusitis, anatomic gal infections ranging from mildly symptomatic to rapidly abnormalities that cause sinus pooling, such as nasal polyps fatal. Fungal colonization of the upper and lower airways is or chronic inflammatory states, do not appear to be signifi- a common condition secondary to the ubiquitous presence cant risk factors for AFIFS.4 of fungal spores in the air. Aspergillus species are the most AFIFS is usually due to Aspergillus species or fungi from prevalent colonizers of the sinuses.1 However, colonization the class Zygomycetes, including Rhizopus, Rhizomucor, Ab- is distinct from infection as the majority of colonized patients sidia, and Mucor.7 In diabetic patients, roughly 80% of AFIFS do not become ill with fungal infections.
    [Show full text]
  • Aspergillosis Complicating Severe Coronavirus Disease Kieren A
    SYNOPSIS Aspergillosis Complicating Severe Coronavirus Disease Kieren A. Marr, Andrew Platt, Jeffrey A. Tornheim, Sean X. Zhang, Kausik Datta, Celia Cardozo, Carolina Garcia-Vidal describing epidemiology and significance of aspergil- Aspergillosis complicating severe influenza infection losis occurring after severe viral infections, especially has been increasingly detected worldwide. Recently, coronavirus disease–associated pulmonary aspergil- influenza and coronavirus disease (COVID-19). losis (CAPA) has been detected through rapid reports, Aspergillosis associated with severe influenza primarily from centers in Europe. We provide a case virus infection (influenza-associated aspergillosis, series of CAPA, adding 20 cases to the literature, with IAA) was reported in 1951, when Abbott et al. de- review of pathophysiology, diagnosis, and outcomes. scribed fatal infection in a woman with cavitary in- The syndromes of pulmonary aspergillosis complicating vasive pulmonary aspergillosis noted on autopsy (2). severe viral infections are distinct from classic invasive Scattered reports appeared in thereafter; Adalja et al. aspergillosis, which is recognized most frequently in summarized 27 cases in the literature during 1952– persons with neutropenia and in other immunocompro- 2011, which reported predominance after influenza mised persons. Combined with severe viral infection, A infection, associated lymphopenia, and occurring aspergillosis comprises a constellation of airway-inva- in persons of a broad age range (14–89 years), but sive and angio-invasive disease and results in risks as- sociated with poor airway fungus clearance and killing, with little underlying lung disease (3). There were including virus- or inflammation-associated epithelial increased numbers of cases reported during and af- damage, systemic immunosuppression, and underlying ter the 2009 influenza A(H1N1) pandemic (3–10).
    [Show full text]
  • Pneumonia in HIV-Infected Patients
    Review Eurasian J Pulmonol 2016; 18: 11-7 Pneumonia in HIV-Infected Patients Seda Tural Önür1, Levent Dalar2, Sinem İliaz3, Arzu Didem Yalçın4,5 1Clinic of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey 2Department of Chest Diseases, İstanbul Bilim University School of Medicine, İstanbul, Turkey 3Department of Chest Diseases, Koç University, İstanbul, Turkey 4Academia Sinica, Genomics Research Center, Internal Medicine, Allergy and Clinical Immunology, Taipei, Taiwan 5Clinic of Allergy and Clinical Immunology, Antalya Training and Research Hospital, Antalya, Turkey Abstract Acquired immune deficiency syndrome (AIDS) is an immune system disease caused by the human immunodeficiency virus (HIV). The purpose of this review is to investigate the correlation between an immune system destroyed by HIV and the frequency of pneumonia. Ob- servational studies show that respiratory diseases are among the most common infections observed in HIV-infected patients. In addition, pneumonia is the leading cause of morbidity and mortality in HIV-infected patients. According to articles in literature, in addition to anti- retroviral therapy (ART) or highly active antiretroviral therapy (HAART), the use of prophylaxis provides favorable results for the treatment of pneumonia. Here we conduct a systematic literature review to determine the pathogenesis and causative agents of bacterial pneumonia, tuberculosis (TB), nontuberculous mycobacterial disease, fungal pneumonia, Pneumocystis pneumonia, viral pneumonia and parasitic infe- ctions and the prophylaxis in addition to ART and HAART for treatment. Pneumococcus-based polysaccharide vaccine is recommended to avoid some type of specific bacterial pneumonia. Keywords: HIV, infection, pneumonia INTRODUCTION Human immunodeficiency virus (HIV) targets the CD4 T-lymphocyte or T cells.
    [Show full text]
  • The Outcome of Fungal Pneumonia with Hematological Cancer
    Infect Chemother. 2020 Dec;52(4):530-538 https://doi.org/10.3947/ic.2020.52.4.530 pISSN 2093-2340·eISSN 2092-6448 Original Article The Outcome of Fungal Pneumonia with Hematological Cancer Esma Eren 1, Emine Alp 2, Fatma Cevahir 3, Tuğba Tok 4, Ayşegül Ulu Kılıç 4, Leylagül Kaynar 5, and Recep Civan Yüksel 6 1Kayseri City Hospital, Infectious Disease Clinic, Kayseri, Turkey 2Ministry of Health, Ankara, Turkey 3Unıversıty of Sakarya Applıed Scıences, Akyazı Vocational School of Health Services, Medical Services and Techniques Department, Sakarya, Turkey 4Erciyes University, Faculty of Medicine, Department of Infectious Disease and Clinical Microbiology, Kayseri, Turkey 5Erciyes University, Faculty of Medicine, Department of Internal Medicine, Hematology, Kayseri, Turkey 6Kayseri City Hospital, Intensive Care Unit, Kayseri, Turkey Received: Jun 24, 2020 ABSTRACT Accepted: Oct 11, 2020 Corresponding Author: Background: Fungal pneumonia is a common infectious complication of hematological Esma Eren, MD cancer (HC) patients. In this retrospective study, the objective was set to identify the risk Infectious Diseases Clinic, City Hospital, factors and outcome of fungal pneumonia in adult HC patients. Kayseri, Turkey. Materials and Methods: Tel: +90-5545965092 This retrospective study was conducted with adult (>16 years) HC E-mail: [email protected] patients from January 2017 and December 2018. Results: During the study period, of 181 patients included 76 were diagnosed with fungal Copyright © 2020 by The Korean Society pneumonia. The most common HC was identified as acute myeloid leukaemia (40%). Of the of Infectious Diseases, Korean Society for participating patients, 52 (29%) were hematopoietic stem cell transplant (HSCT) recipients. Antimicrobial Therapy, and The Korean Society for AIDS The median age of patients with fungal pneumonia was significantly greater: 57vs.
    [Show full text]
  • A Case Report of Fungal Infection Associated Acute Fibrinous and Organizing Pneumonitis Jiangnan Zhao1, Yi Shi1, Dongmei Yuan1, Qunli Shi2, Weiping Wang3 and Xin Su1*
    Zhao et al. BMC Pulmonary Medicine (2020) 20:98 https://doi.org/10.1186/s12890-020-1145-7 CASE REPORT Open Access A case report of fungal infection associated acute fibrinous and organizing pneumonitis Jiangnan Zhao1, Yi Shi1, Dongmei Yuan1, Qunli Shi2, Weiping Wang3 and Xin Su1* Abstract Background: Acute fibrinous and organizing pneumonitis (AFOP) is an uncommon variant of acute lung injury, characterized by intra-alveolar fibrin and organizing pneumonia. Proposed etiologies include connective tissue diseases, infections, occupational exposure, drug reactions, and autoimmune disease. Here we present a rare case of fungal infection associated AFOP in patient with diabetes mellitus (DM) and review the relevant literature. Case presentation: A 67-year-old man complained of cough, fever, dyspnea and hemoptysis. Patient experienced a rapidly progressive course exhibit diffuse predominant consolidation, ground glass opacities, and multifocal parenchymal abnormalities on chest computed tomography (CT). Antibacterial, antifungal, and antiviral treatments were ineffective. A CT-guided percutaneous lung biopsy was performed. Histologically, the predominant findings were as follows: alveolar spaces filled with fibrin and organizing loose connective tissues involving 70% of the observed region, pulmonary interstitial fibrosis, and small abscesses and epithelioid cell granuloma in the focal area. Result of periodic acid-silver methenamine stain was positive. The fungal pathogen from the sputum culture was identified as P. citrinum repeatedly over 3 times. Patient was diagnosed with DM during hospitalization. Corticosteroids combined with an antifungal therapy were effective. Follow-up for 4 months showed complete radiological resolution. Conclusions: As this common “contaminant” can behave as a pathogen in the immunocompromised host, both clinicians and microbiologists should consider the presence of a serious and potentially fatal fungal infection on isolation of P.
    [Show full text]
  • Treatment of Fungal Infections in Adult Pulmonary and Critical Care Patients
    American Thoracic Society Documents An Official American Thoracic Society Statement: Treatment of Fungal Infections in Adult Pulmonary and Critical Care Patients Andrew H. Limper, Kenneth S. Knox, George A. Sarosi, Neil M. Ampel, John E. Bennett, Antonino Catanzaro, Scott F. Davies, William E. Dismukes, Chadi A. Hage, Kieren A. Marr, Christopher H. Mody, John R. Perfect, and David A. Stevens, on behalf of the American Thoracic Society Fungal Working Group THIS OFFICIAL STATEMENT OF THE AMERICAN THORACIC SOCIETY (ATS) WAS APPROVED BY THE ATS BOARD OF DIRECTORS, MAY 2010 CONTENTS immune-compromised and critically ill patients, including crypto- coccosis, aspergillosis, candidiasis, and Pneumocystis pneumonia; Introduction and rare and emerging fungal infections. Methods Antifungal Agents: General Considerations Keywords: fungal pneumonia; amphotericin; triazole antifungal; Polyenes echinocandin Triazoles Echinocandins The incidence, diagnosis, and clinical severity of pulmonary Treatment of Fungal Infections fungal infections have dramatically increased in recent years in Histoplasmosis response to a number of factors. Growing numbers of immune- Sporotrichosis compromised patients with malignancy, hematologic disease, Blastomycosis and HIV, as well as those receiving immunosupressive drug Coccidioidomycosis regimens for the management of organ transplantation or Paracoccidioidomycosis autoimmune inflammatory conditions, have significantly con- Cryptococcosis tributed to an increase in the incidence of these infections. Aspergillosis Definitive
    [Show full text]
  • The “Reversed Halo” Sign in Pneumonococcal Pneumonia: a Review with a Case Report
    European Review for Medical and Pharmacological Sciences 2010; 14: 481-486 The “reversed halo” sign in pneumonococcal pneumonia: a review with a case report V. TZILAS, A. BASTAS, A. PROVATA, A. KOTI, V. TZOUDA, G. TSOUKALAS 4th Respiratory Medicine Department, Athens Chest Disease Hospital, Sotiria (Greece) Abstract. – The “reversed halo” sign The patient was febrile with a temperature of (RHS) is a distinct radiological sign representing 38.5°C (101.3oF). Her heart rate was 100 to 110 a focal rounded area of ground-glass opacity beats per minute with a sinus rhythm revealed on surrounded by a more or less complete ring of consolidation. Initially, it was reported in two ECG. Respiratory rate was 18 to 20 breaths per cases of cryptogenic organizing pneumonia and minute. She was hemodynamically stable with a was considered to be relatively specific of the blood pressure of 115/70 mm Hg. Auscultation disease. Since then, it has been reported in a of the lungs revealed crackles in the right lung wide variety of clinical entities, thus reducing its base. specificity. We describe the reversed halo sign in There was no clubbing, cervical or axillary a case of pneumonococcal pneumonia. To the best of our knowledge, this is the first report in lymphadenopathy, skin lesions or joint swelling. English literature. The presence of the “reversed Physical examinations of the rest systems did halo” sign during the resolution phase of pneu- not provide any significant information. monococcal pneumonia has serious implica- Total blood count revealed a mild nor- tions. First, it further reduces its specificity.
    [Show full text]
  • Extensive Cavitary Fungal Pneumonia in a Patient with COVID-19 Infection
    Extensive Cavitary Fungal Pneumonia in A Patient With COVID-19 Infection Madiha Iqbal Aga Khan University Hospital Sher Muhammad Sethi ( [email protected] ) Aga Khan University Hospital https://orcid.org/0000-0001-7066-7124 Sadaf Hanif Aga Khan University Hospital Abdullah Ameen Aga Khan University Hospital Research Article Keywords: COVID-19, aspergillosis, thick walled cavitation, CAPA Posted Date: July 19th, 2021 DOI: https://doi.org/10.21203/rs.3.rs-683851/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/8 Abstract Introduction: Coronavirus disease 19 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). With the ongoing pandemic, it is observed that patients with COVID-19 infections are at increased risk of acquiring secondary bacterial and fungal infections. COVID-19 associated pulmonary aspergillosis (CAPA) is a new entity and is associated with high morbidity and mortality. COVID-19 is a pro-inammatory and immunosuppressive disease, provoking fungal infections, especially by Aspergillus species. Case Presentation: We describe a case of critically ill COVID-19 female patient. During her hospital course, she was intubated managed as ARDS and started on empiric antibiotics along with intravenous remdesivir. Clinically she improved and was extubated. Her chest x-ray few days after admission showed multiple cavities. However, 3days post extubation she deteriorated, with worsening hypoxia and pneumothorax and multiple cavitary lesions on HRCT of the chest. Her tracheal cultures showed aspergillus avus with rising serum galactomannan and beta D-glucan. She was diagnosed with coronavirus disease (COVID-19) associated pulmonary aspergillus (CAPA) infection and acute respiratory distress syndrome (ARDS).
    [Show full text]
  • Fungal Pneumonia in the Immunocompetent Host: a Possible
    Original Article Mol Imaging Radionucl Ther 2020;29:72-78 DOI:10.4274/mirt.galenos.2020.32154 Fungal Pneumonia in The Immunocompetent Host: A Possible Statistical Connection Between Allergic Fungal Sinusitis with Polyposis and Recurrent Pulmonary Infection Detected by Gastroesophageal Reflux Disease Scintigraphy İmmünokompetan Hastada Fungal Pnömoni: Polipozis ile Alerjik Fungal Sinüzit ve Gastroözefageal Reflü Sintigrafisi ile Saptanan Tekrarlayan Pulmoner Enfeksiyon Arasında Olası İstatistiksel Bağlantı Leticia Burton1, Karl Baumgart2, Daniel Novakovic3, John Beattie4, David Joffe5, Gregory Falk5, Hans Van der Wall1 1University of Notre Dame, CNI Molecular Imaging, Sydney, Australia 2North Shore Medical Centre, Sydney, Australia 3University of Sydney, Sydney, Australia 4Ryde Medical Centre, Sydney, Australia 5Royal North Shore Hospital, Sydney, Australia Abstract Objectives: Fungal pneumonia in the immune competent host is a rarity with few reported cases in the literature. We present a series of 7 cases of recurrent fungal pneumonia in association with allergic fungal rhinosinusitis and gastroesophageal reflux disease (GERD). We hypothesised that recurrent infection may have been transported from the infected paranasal sinuses into the lung by GERD as the process was terminated by surgical fundoplication in 2 of these patients. Methods: Patients were recruited into the study if they were immune competent and had recurrent fungal pneumonia and GERD. Allergic fungal rhinosinusitis was proven by biopsy. GERD was investigated by a scintigraphic test that assessed local oesophageal disease, lung aspiration and head and neck involvement with a hybrid gamma camera and X-ray computed tomography. Results: All patients were shown to have GERD with 5/7 showing paranasal sinus contamination and 7/7 showing laryngopharyngeal involvement and 6/7 lung aspiration.
    [Show full text]
  • Fungal Pneumonia in Dogs and Cats with Pulmonary Clinical Signs in Southern Brazil1 Mariana Pavelski2*, Sandra V
    Pesq. Vet. Bras. 38(4):696-702, abril 2018 DOI: 10.1590/1678-5150-PVB-5066 Vet 2615 pvb-5066 SA Fungal pneumonia in dogs and cats with pulmonary clinical signs in southern Brazil1 Mariana Pavelski2*, Sandra V. Seixas3, José Francisco G. Warth4, Cybelle de Souza4, Rosangela L. Dittrich4 and Tilde R. Froes4 ABSTRACT.- Pavelski M., Seixas S.V., Warth J.F.G., Souza C., Dittrich R.L. & Froes T.R. 2018. Fungal pneumonia in dogs and cats with pulmonary clinical signs in southern Brazil. Pesquisa Veterinária Brasileira 38(4):696-702. Departamento de Medicina Veterinária, Universidade Federal do Paraná, Rua dos Funcionários 1540, Curitiba, PR 80035-050, Brazil. E-mail: [email protected] Fungal pneumonia has been a differential diagnosis in dogs and cats with pulmonary clinical signs, posting also a public health risk to respective owners. Since a common-source environmental exposure may result in infection, dogs and cats may also act as sentinels for both animal and human disease. Accordingly, the present study has aimed to evaluate the occurrence of fungal pneumonia in dogs and cats with pulmonary clinical signs from May 2013 to February 2015 in southern Brazil. Thoracic radiographs, blood work and non-bronchoscopic Bronchoalveolar Lavage (BAL), followed by cytology and microbiologic pathogenic fungus (Cryptococcus neoformans) and another dog to an opportunistic fungus analysis(Candida were parapsilosis) performed. Both in dogsall animals. have presented One dog coughwas positive as the prior in the clinical BAL fluid sign culture and showed for a thoracic radiographic changes. In conclusion, the occurrence of fungal pneumonia in southern allow diagnosis of fungal pneumonia caused by opportunistic or pathogenic fungi and this Brazildiagnosis in dogs should and be cats a concern through in of dogs this andstudy cats was with relatively pulmonary low.
    [Show full text]