Establishment of a Novel in Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis
cancers Article Establishment of a Novel In Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis Mohammad Mahmud Hossain 1, Kentaro Nakayama 1,*, Kamrunnahar Shanta 1 , Sultana Razia 1, Masako Ishikawa 1, Tomoka Ishibashi 1, Hitomi Yamashita 1, Seiya Sato 1, Kouji Iida 1, Kosuke Kanno 1, Noriyoshi Ishikawa 2, Tohru Kiyono 3,* and Satoru Kyo 1 1 Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan; likhon.vet@gmail.com (M.M.H.); kamrunnahar.vet@gmail.com (K.S.); raeedahmed@yahoo.com (S.R.); m-ishi@med.shimane-u.ac.jp (M.I.); tomoka@med.shimane-u.ac.jp (T.I.); meme1103@med.shimane-u.ac.jp (H.Y.); sseiya@med.shimane-u.ac.jp (S.S.); iida@med.shimane-u.ac.jp (K.I.); kanno39@med.shimane-u.ac.jp (K.K.); satoruky@med.shimane-u.ac.jp (S.K.) 2 Department of Organ Pathology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan; kanatomo@med.shimane-u.ac.jp 3 Project for Prevention of HPV-Related Cancer, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Kashiwa 277-8577, Japan * Correspondence: kn88@med.shimane-u.ac.jp (K.N.); tkiyono@east.ncc.go.jp (T.K.) Citation: Hossain, M.M.; Nakayama, Simple Summary: Endometriosis is a common gynecological condition that causes pelvic pain and K.; Shanta, K.; Razia, S.; Ishikawa, M.; infertility. Despite having normal histological features, several cells bear cancer-associated somatic Ishibashi, T.; Yamashita, H.; Sato, S.; mutations that result in local tissue invasion but rarely metastasize.
[Show full text]