Drug-Induced Fatty Liver Disease
789 Drug-induced fatty liver disease. , 2015; 14CONCISE (6): 789-806 REVIEW November-December, Vol. 14 No. 6, 2015: 789-806 Drug-induced fatty liver disease: An overview of pathogenesis and management Sanjaya K. Satapathy,* Vanessa Kuwajima,** Jeffrey Nadelson,** Omair Atiq,*** Arun J. Sanyal**** * Methodist University Hospital Transplant Institute, Division of Surgery, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA. ** Division of Gastroenterology and Hepatology, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA. *** University of Texas Southwestern, Dallas, Texas, USA. **** Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia, USA. ABSTRACT Over the past decades, many drugs have been identified, that can potentially induce steatohepatitis in the predisposed individual. Classically this has been incriminated to amiodarone, perhexiline, and 4,4’-diethyla- minoethoxyhexestrol (DH), all of which have been found to independently induce the histologic picture of non-alcoholic steatohepatitis (NASH). Pathogenetic mechanisms of hepatotoxicity although still evolving, demonstrate that mitochondrial dysfunction, deranged ATP production and fatty acid catabolism likely play an important role. Drugs like steroid hormones can exacerbate the pathogenetic mechanisms that lead to NASH, and other drugs like tamoxifen, cisplatin and irenotecan have been shown to precipitate la- tent fatty liver as well. Further research aiming to elucidate
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