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Home , Colestyramine, Perhexiline

BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) BMJ Open

Supplementary Table 1 – Injury categories

Injury Category ICD Codes Fractures S02, S12, S22, S32, S42, S52, S62, S72, S82, S92, T02.1-5, T02.8-9, T08, T10, T12, T14.2, T90.2, T91.1-2 T92.1-2, T93.1-2 Open Wounds S01, S05.2, S05.3, S05.4, S05.5, S05.6, S05.7, S08.0, S09.2, S11, S21, S31.0-5, S31.7-8, S41, S51, S61, S71.0-8, S81, S91, T01.2-3, T01.9, T09.1, T11.1, T13.1, T14.1, T90.1, T92.0, T93.0, Contusions and superficial S00, S05.0-1, S10, S20, S30.0-2, S30.7-9, S40, S50, S60, S70, S80, S90, T00.2-3, T00.8- injuries 9, T09.0, T11.0, T13.0, T14.0, T90.0 Dislocations S03.0-3, S13.0-3, S23.0-3, S33.0-4, S43.0-3, S53.0-1, S63.0-2, S66, S73.0, S83, S86, S93.0-1, S93.3 Internal organ injuries S06, S14.0-2, S24.0-1, S26.0, S27.0-6, S27.8-9, S34.0-1, S34.3, S36, S37, S39.6-7, T06.5, T09.3, T90.5, T91.3-5 Foreign bodies T15-9 Amputations S08.1-9, S18, S28.1, S38.2-3, S48, S58, S68, S78, S88, S98, T05.0, T05.2-3, T05.5, T05.8-9, T09.6, T11.6, T13.6 Burns T20-T32

Randall SM, et al. BMJ Open 2020; 10:e039104. doi: 10.1136/bmjopen-2020-039104 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) BMJ Open

Supplementary Table 2 – Description ATC cardiovascular agents

Cardiovascular system Examples of agents C - ATC codes C01 – Cardiac therapy Includes cardiac glycosides, antiarrhythmic, adrenergic vasodilators (organic nitrates) agents C02 - Antihypertensive Includes central acting antiadrenergic agents (methyldopa), imidazoline agonists (clonidine), alpha adrenergic blocking agents (prazosin), hydrazinophthalazine derivatives (hydralazine) C03 - Diuretics Includes low ceiling diuretics (), high ceiling diuretics (e.g. , frusemide), potassium sparing including aldosterone, , and combined low ceiling and potassium sparing diuretics C07 – Beta blockers Includes non-selective beta blockers (e.g. oxprenolol, pindolol, propranolol, ); selective beta blockers (e.g. atenolol, bisoprolol, metoprolol); alpha and beta adrenoceptor blockers (e.g. carvedilol, labetalol, C08 – blockers Includes dihydropyridine derivatives , , lercanipidine, ; selective - phenylalkylamine derivatives and benzothiazepine derivatives ; non-selective perhexiline. C09 – Agents acting on renin - Includes converting enzyme blockers ACE inhibitors (e.g. captopril, enalapril, angiotensin system fosinopril, lisinopril, perindopril, ramipril, trandolapril); Angiotensin II antagonist plain (e.g. candesartan, eprosartan, irbesarten); other angiotensin II antagonists (losartan, olmesartan, telisartan, valsartan). C10 – Lipid modifying agents Includes HMG reductase inhibitors (e.g. , , , , ); (e.g. ); acid sequestrants (colestyramine, ); nicotinic acid and derivatives.

Randall SM, et al. BMJ Open 2020; 10:e039104. doi: 10.1136/bmjopen-2020-039104