GREEN BOOK 2 & GREEN BOOK 3 Vegetable Oils Nut Oils CIR

GREEN BOOK 2 & GREEN BOOK 3

Vegetable Oils Nut Oils

CIR EXPERT PANEL MEETING AUGUST 30-31, 2010

GREEN BOOK 2

Oils

CIR EXPERT PANEL MEETING AUGUST 30-31, 2010

CIR Panel Book Page 1 Memorandum

To: CIR Expert Panel Members and Liaisons

From: Christina L. Burnett, Scientific Writer/Analyst

Date: July 30, 2010

Subject: Draft Report of the Vegetable Oil Group

The Scientific Literature Review (SLR) for this group of edible vegetable (and fruit) oils was announced April 23, 2010. A related SLR on edible nut oils was announced in June of this year, and is to be reviewed by the Panel at this meeting as well. If the Panel does not see any major differences in the overall toxicity potential of these two oil groups, it may consider combining the reports into one major edible oil report.

Both reports are taking a slightly new approach to reviewing multiple related ingredients at one time and are including oil ingredients that have previously been reviewed by the CIR Expert Panel, which are designated in italic print.

At the time that the SLR was announced, CIR sought the following additional information:

1. Manufacturing information about oils used in cosmetic formulation, particularly on methods used to remove non-fatty acid components (e.g., glycidol fatty acid esters); 2. Cosmetic grade specifications, if such exist, for oils used in cosmetic formulations. 3. Fatty acid composition for those oils covered in this report (where such information has not been provided or differs from what is presented). 4. Irritation and sensitization testing on cosmetics (finished products) containing specified concentrations of oils covered in this report. 5. Irritation and sensitization testing on those fatty acids present in the oils covered in this report that have previously not been reviewed by CIR. 6. Any other information that pertains to the safety of the use in cosmetics of the oils covered in this report. Data on fatty acid compositions and cosmetic grade specifications, as well as an HRIPT studies on numerous oils have been received from the Personal Care Products Council and are incorporated in this draft report in Tables 3, 4, and 7, respectively. Due to the voluminous amount of unpublished data (800+ pages), data will be accessible online. Paper copies will be mailed out only by request.

Please note that the new use table is being employed in this report. The raw data from which the table was created along with any available concentration of use information have been included in the book materials.

If the data provided are sufficient for the Panel to assess the safety of these ingredients, a tentative conclusion should be developed regarding their safety in cosmetics, along with a rationale for that conclusion. The report will then be issued as a Tentative Safety Assessment. If additional data are needed, these should be identified and an Insufficient Data Announcement should be issued.

For your convenience, the materials for this report can also be found at http://www.cir-safety.org/aug10.shtml.

CIR Panel Book Page 2

CIR Panel Book Page 3 CIR Expert Panel History with Vegetable Oils

April 2010 - CIR issued a Scientific Literature Review.

CIR Panel Book Page 4 Literature Search on Vegetable Oils

Ingredients Toxline ChemIDplus HSDB CAplus NTIS HPV Merck USP PubMed

√ √ √ √ √ √ √

Ingredients were searched by Latin botanical (INCI) names, common names, and CAS numbers, when available. The list of ingredients searched is found in Table 1 of the vegetable oil report.

Literature searches included chemical composition, fatty acid composition, dermal toxicity, irritation, and sensitization qualifiers.

Searches were performed between November 20, 2009 and March 30, 2010 and updated June 30 through July 8, 2010.

CIR Panel Book Page 5 Report

CIR Panel Book Page 6 Draft Report

Vegetable Oil, Related Plant-Derived Oils, and Other Derivatives as Used in Cosmetics

August 30, 2010

The 2010 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; Ronald A Hill, Ph.D. James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is F. Alan Andersen, Ph.D. This report was prepared by Christina L. Burnett and Monice Fiume, Scientific Analyst/Writers.

CIR Panel Book Page 7 TABLE OF CONTENTS

INTRODUCTION ...... 1 Chemistry ...... 1 Processing ...... 2 Analytical Methods ...... 2 Impurities ...... 2 Use ...... 3 Cosmetic ...... 3 Non-Cosmetic ...... 4 ANIMAL TOXICOLOGY ...... 4 OILS ...... 4 Dermal Irritation/Sensitization/Phototoxicity ...... 4 Adansonia Digitata Seed Oil [Baobab] ...... 4 Carthamus Tinctorius (Safflower) Oil ...... 4 Gossypium Herbaceum (Cotton) Seed Oil...... 4 Elaeis Guineensis (Palm) Oil ...... 5 Olea Europea (Olive) Fruit Oil ...... 5 Oryza Sativa (Rice) Bran Oil and Germ Oil ...... 5 Sesamum Indicum (Sesame) Seed Oil ...... 5 Triticum Vulgare (Wheat) Germ Oil ...... 6 Zea Mays (Corn) Oil ...... 6 Ocular Irritation ...... 6 Adansonia Digitata Seed Oil [Baobab] ...... 6 Elaeis Guineensis (Palm) Oil ...... 6 Gossypium Herbaceum (Cotton) Seed Oil...... 6 Linum Usitatissimum (Linseed) Seed Oil ...... 6 Olea Europea (Olive) Fruit Oil ...... 7 Oryza Sativa (Rice) Bran and Rice Germ Oil ...... 7 Ribes Nigrum (Black Currant) Seed Oil ...... 7 Sesamum Indicum (Sesame) Seed Oil ...... 7 Triticum Vulgare (Wheat) Germ Oil ...... 7 Zea Mays (Corn) Oil ...... 7 CARCINOGENICITY ...... 7 CLINICAL ASSESSMENT OF SAFETY ...... 8 Irritation/Sensitization/Allergenicity ...... 8 Carthamus Tinctorius (Safflower) Oil ...... 9 Elaeis Guineensis (Palm) Oil ...... 9 Gossypium Herbaceum (Cotton) Seed Oil...... 9 Oryza Sativa (Rice) Bran Oil ...... 9 Persea Gratissima (Avocado) Oil ...... 9 Sesamum Indicum (Sesame) Seed Oil ...... 9 Triticum Vulgare (Wheat) Germ Oil ...... 9 Ocular Irritation ...... 9 Linum Usitatissimum (Linseed) Seed Oil ...... 9 Ribes Nigrum (Black Currant) Seed Oil ...... 10 Comedogenicity ...... 10 Ribes Nigrum (Black Currant) Seed Oil ...... 10 Case Studies ...... 10 Glycine Soja (Soybean) Oil ...... 10 Helianthus Annuus (Sunflower) Oil ...... 10 Olea Europea (Olive) Fruit Oil ...... 11 Persea Gratissima (Avocado) Oil ...... 11 SUMMARY ...... 11 FIGURES AND TABLES ...... 14 Figure 2. Basic oil refinement flowchart.3 ...... 15 Table 2. Previously reviewed oil and fatty acid ingredients...... 18 Table 3. Fatty acid composition...... 20 Table 4. Chemical properties...... 26 ii

CIR Panel Book Page 8 Table 5. Frequency of use according to duration and exposure...... Error! Bookmark not defined. Table 6. Non-food, non-cosmetic uses of edible oils.3 ...... 42 REFERENCES ...... 48

iii

CIR Panel Book Page 9 INTRODUCTION Vegetable oil and related edible seed oils have been safely consumed by humans for millennia. Because there is no significant safety concern with these ingredients following oral exposure and their general biology is well characterized due to extensive use in food materials, this safety assessment will focus solely on the basic chemistry, manufacturing/production, uses, and irritation and sensitization data available on these oils as they are used in cosmetic ingredients. Various oils have been used on the skin since antiquity. Initially used for anointing in religious ceremonies, oils and their components have long been used on the skin for cosmetic purposes. The full list of ingredients this report covers, which includes oils, hydrogenated oils, unsaponifiables, oil fatty acids, and simple salts, is found in Table 1. For the sake of brevity, the common name of the oil, when available, will be used throughout this report. While a large number of oils derived from plants are included in this literature review, there is a commonality in that they all are mixtures of triglycerides containing fatty acids and fatty acid derivatives, the safety of which in cosmetics have been established.

This report includes cosmetic ingredients that have been previously reviewed by the Cosmetic Ingredient Review Expert

Panel. The ingredients, their conclusion, and published citations are found in Table 2. Previously reviewed fatty acids and glyceryl triesters are also found in Table 2. This report excludes tree and ground nut oils, are covered in another safety assessment.

CHEMISTRY The group of ingredients characterized as fats and oils are the glyceryl esters of fatty acids (triglycerides) normally found in plant tissues, including those which have been hydrogenated to reduce or eliminate unsaturation.1 Figure 1 is the general structure of fats and oils. The raw oil may include plant sterols, pigments, glucosides, proteins, vitamins and impurities. The extent to which these components are removed during processing varies. The available fatty acid compositions for the oils in this report are found in Table 3. The available information on chemical properties and other constituents, including Food Chemicals

Codex specifications when provided, are found in Table 4.2

The percentage of chemical constituents in individual oil types is dependent on region where the oilseed plant is grown, individual cultivars, and plant genetics.3 This is especially true in with rapeseed, where the erucic acid content varies from 1% to

58.6%. Low erucic acid rapeseed oil is also known as canola oil.

The nutritional content of these oils varies with oil type. For example, sunflower oil contains high levels of vitamins A,

D, and K, while palm oil is a rich source of vitamins A and E. Crude sunflower oil also has the highest content of vitamin E in the form of α-tocopherol amongst vegetable oils.3

CIR Panel Book Page 10 Processing Oils used in cosmetics are probably produced using the same process used in the food industry. Depending on the source, oil may be directly expressed from the source (seed or pulp) followed by solvent extraction. Bailey’s Industrial Oil and Fat

Products states that the removal of pigments and polar materials is mandatory for most cosmetic applications.4 The process used for oil refining for foods may be adequate for this purpose, or additional steps may be required. Special refining methods to yield colorless and odorless oils are used by the cosmetic industry and include proprietary adsorption chromatography and supercritical fluid extractions.

The majority of the oils presented in this report are produced either from mechanical extraction or solvent extraction or a hybrid of both methods, known as prepress solvent extraction.3 In solvent extraction, hexane is the most commonly used solvent as it is economical and has low toxicity potential when compared to other solvents. Seeds that are rich in oil can be cold pressed to extract oil without the use of solvents.5

After the initial extraction by methods such as solvent extraction, the crude (degummed) oil is often refined.3 The first step is treating the oil with caustic soda to neutralize free fatty acids, hydrolyze phosphatides, and remove some colored pigments and unsaponifiable materials. Soap stock is usually a by-product of this step. The next step involves bleaching the neutralized oil with activated earth to further absorb pigments. The last major step in refining oil is deodorizing, which removes all oxidative cleavage products that impart odor or flavor to the oil. Deodorization also removes tocopherols, sterols, and other minor constituents of free fatty acids and undesirable foreign materials. Figure 2 is a flowchart of the basic refinement process.

After deodorization, oils can be further processed by hydrogenation, which makes oil more resistant to oxidative and thermal damage, and by winterization, where oil is slowly cooled to promote formation of crystals that cause cloudiness and filtered to remove the crystals.

Cosmetic grade vegetable oils may include a physical refining step that involves heating crude vegetable oil under vacuum.5 This step allows for the removal of volatile components such as color compounds, odor compounds, and free fatty acids, which gives the refined oil a lighter color, less odor, and lower acid values.

Analytical Methods According to Crevel et al., a validated analytical methodology for establishing the protein content of oil is needed.6

Impurities Many edible oils are derived from foods that are recognized as potent food allergens. It has been shown that often an individual that is allergic to a food will generally not react to the refined oil.6 It should be noted that while the Panel has found a general lack of clinical effects for edible oils already reviewed,7-15 other researchers have raised concerns. Halsey et al. reported that Lowry protein determinations of cold-pressed and refined sunflower oil found 2-8 µg/ml protein,16 while Zitouni et al.

CIR Panel Book Page 11 reported trace amounts of protein in the refined oil.17 Olszewski et al. found 0.1-0.2 µg protein per g of peanut oil,18 while

Ramazzotti et al. reported finding IgE responsive residual proteins in peanut oil extracts.19 Porras et al. found soy protein is some samples of soy oil, but not others.20 Awazuhara et al. reported 1.4-4.0 µg protein per 100 g of soy oil.21 Although Paschke et al. found approximately 35 µg/ml protein content in refined soybean oil, no IgE-binding activity was detectable.22 The European

Medicines Agency (EMEA) Working Party on Herbal Medicinal Products concluded that soy and peanut products “should be treated as allergenic unless they have an analytically-monitored non-allergenic specification and a safe maximum daily dose.”23

The EMEA found that threshold concentrations for induction of a protein contact dermatitis were not available and recommended that “all medications for topical use containing soya or peanut products should be treated as allergenic.”

USE Cosmetic Oils are used in a wide variety of cosmetic products for their skin conditioning, occlusive, emollient, moisturizing and other properties. A total of 124 of the 208 oil ingredients included in this safety assessment are reported to be used; 108 of the in- use ingredients have never been reviewed by CIR, while 16 have been reviewed previously. For the ingredients being reviewed for the first time, the frequency of use, as supplied to the Food and Drug Administration (FDA) by industry as part of the

Voluntary Cosmetic Registration Program (VCRP),24 and/or concentration of use, as supplied by industry in response to a Personal

Care Products Council (Council) survey,25,26 can be found in Table 5a. For the ingredients that have been reviewed previously, the current and historical8,10,11,15,27-30 frequency and concentration of use is given in Table 5b. The 84 ingredients not currently reported to be used are listed in Table 5c. Table 5d lists the 41 ingredients for which a concentration of use survey has not yet been completed.

Sunflower seed oil has the greatest number of reported uses in cosmetic and personal care products, with a total of 1414.

Many other ingredients are used in an extensive number of formulations. For example, olive oil and soybean oil have 915 and 912 uses, respectively. Most of the in-use ingredients have uses in both leave-on and rinse-off product types, and many are used in products that are applied around the eye or that can possibly be ingested. Some are used in products that involve mucous membrane exposure, and a few are used in underarm deodorant formulations. Many of the products are used in formulations at relatively high concentrations. Olive oil is used at up to 100%, avocado oil is used at up to 98%, sunflower seed oil at up to 96%, and soybean oil at 95%.

The oil ingredients described in this report may be used in hair sprays, and effects on the lungs that may be induced by aerosolized products containing these ingredients are of concern. The aerosol properties that determine deposition in the respiratory system are particle size and density. The parameter most closely associated with deposition is the aerodynamic diameter, da, defined as the diameter of a sphere of unit density possessing the same terminal settling velocity as the particle in

CIR Panel Book Page 12 question. In humans, particles with an aerodynamic diameter of ≤ 10µm are respirable. Particles with a da from 0.1 - 10µm settle

31,32 in the upper respiratory tract and particles with a da < 0.1 µm settle in the lower respiratory tract.

Particle diameters of 60-80 µm and ≥80 µm have been reported for anhydrous hair sprays and pump hairsprays, respectively.33 In practice, aerosols should have at least 99% of their particle diameters in the 10 – 110 µm range and the mean particle diameter in a typical aerosol spray has been reported as ~38 µm.34 Therefore, most aerosol particles are deposited in the nasopharyngeal region and are not respirable.

None of the oils or their related counterparts described in this report were restricted from use in any way under the rules governing cosmetic products in the European Union.35

Non-Cosmetic The primary uses for edible oils are for cooking. Palm oil is the world's most widely consumed edible oil (41.7 million metric tons), followed by soybean oil, rapeseed oil, sunflower seed oil, cottonseed oil, peanut oil, palm kernel oil, coconut oil, ,and olive oil.3,36 Non-food, non-cosmetic uses for edible oils are found in Table 6.

ANIMAL TOXICOLOGY

OILS Irritation, sensitization and phototoxicity data available were reviewed and are summarized below. Information from previous CIR reports on edible oils is identified by italics. No information was found for some of the oils listed in this report.

Dermal Irritation/Sensitization/Phototoxicity

Adansonia Digitata Seed Oil [Baobab]

In an alternative to the Draize test, 100% baobab oil was tested for dermal irritation in a MatTek EpiDerm ™ MTT viability assay.37 The MatTek EpiDerm™ tissue samples were incubated with 100 µl of the test material for 1, 4, or 24 h along with the positive control material, 1% Triton X-100, which was incubated for 4 or 9 h, and the negative control, undosed tissues, which were incubated for 4 h. After treatment, the viability of the tissues was determined with MTT uptake and conversion. The positive control provided expected results. The test material was classified as non-irritating.

Carthamus Tinctorius (Safflower) Oil

Undiluted safflower oil was minimally irritating in a repeat open patch test using rabbits and was not a primary irritant or sensitizer in a maximization study using guinea pigs15.

Gossypium Herbaceum (Cotton) Seed Oil

Cosmetic formulations containing 3.4-8.97% hydrogenated cottonseed oil were not irritating to rabbit skin.10

CIR Panel Book Page 13 Elaeis Guineensis (Palm) Oil

Undiluted palm oil was practically non- to minimally irritating to rabbit skin.8 Palm oil, 5%, was non-allergenic in a maximization study. A facial lotion containing 1.5% palm oil was not phototoxic in the phototoxicity yeast assay.

Olea Europea (Olive) Fruit Oil

Hartley and/or Himalayan guinea pigs were used to determine the sensitization potential of olive oil. 38 Single drops of a

USP-grade olive oil that had been stored in its original metal container for 10 yrs were applied to an area clipped free of hair on the backs of 12 guinea pigs. (The composition of the oil was not determined.) Applications were made at 2-6 wk intervals over a period of 5 mos. Four guinea pigs were treated similarly using store-bought virgin olive oil. None of the animals had a positive reaction following the initial application of either oil. Using the 10-yr-old olive oil, 11 of 12 of the animals had a positive reaction at some point during the study. Some, but not all, of these guinea pigs reacted consistently following the first positive reaction; 2 animals had only one positive reaction. Two guinea pigs in this group died by wk 16. In the group dosed with virgin olive oil, one animal had a positive reaction at wk 2 and one animal had a positive reaction at wks 4 and 6.

Twenty-two guinea pigs sensitive to the 10-yr-old USP olive oil were used to determine cross-reactivity with the store- bought virgin olive oil, another store-bought olive oil (not specified as virgin olive oil), corn oil, and peanut oil. The 5 oils were applied simultaneously to the backs of the guinea pigs. Eighteen of the animals reacted to the virgin olive oil, and 18 reacted to the other store-bought olive oil. (Overlap of these animals was not complete.) Cross-reactivity to corn or peanut oil was not observed.

The researchers then applied single drops of the unsaponifiable fraction of the 10-yr-old oil to 8 sensitized and 4 non- sensitized guinea pigs. All of the sensitized animals reacted to the unsaponifiable fraction, while the non-sensitized animals did not react.

Olive oil is used as a vehicle in the murine local lymph node assay (LLNA), an in vitro assay developed to assess a chemical’s potential to induce allergic contact dermatitis in humans.39 The LLNA protocol states that the solvent/vehicle should be selected on the basis of maximizing the test concentrations while producing a solution/suspension suitable for application of the test substance. The recommended vehicle is acetone/olive oil (4:1 v/v).

Oryza Sativa (Rice) Bran Oil and Germ Oil

Undiluted rice bran oil was not irritating to rabbits, and in a guinea pig maximization study, no reactions were observed when 55 was used at induction and 25 and 50% rice bran oil were used at challenge. 11 Rice germ oil was not a primary dermal irritant, and a rice bran oil/rice germ oil mixture, concentrations not stated, did not cause a contact allergy response. Undiluted hydrolyzed rice protein was also not irritating or sensitizing. Undiluted rice bran oil and rice germ oil, ≤75%, were not phototoxic or photosensitizing.

Sesamum Indicum (Sesame) Seed Oil 5

CIR Panel Book Page 14 Undiluted sesame oil was non- or minimally irritating to rabbit skin.30

Triticum Vulgare (Wheat) Germ Oil

Wheat germ oil, undiluted and at 2% in formulation, was non- to mildly irritating, and undiluted wheat germ oil was not sensitizing to guinea pigs.13

Zea Mays (Corn) Oil

A group of 6 Hartley and/or Himalayan guinea pigs were used to determine the sensitization potential of store-bought corn oil. 38 None of the animals had a positive reaction following the initial application. Two animals had positive reactions following application at wks 4 and 6, while one animal had a positive reaction following application at wk 12.

Ocular Irritation Adansonia Digitata Seed Oil [Baobab]

In an alternative to the Draize rabbit eye test, 100% baobab oil was tested for ocular irritation in a MatTek EpiOcular ™

MTT viability assay.37 The MatTek EpiOcular™ tissue samples were treated with 100 µl of the test material for 16, 64, or 256 minutes along with the positive control material, 0.3% Triton X-100, which was treated for 15 or 45 minutes, and the negative control, tissue culture water, which was treated for 16 minutes. After treatment, the viability of the tissues was determined with

MTT uptake and conversion. The positive control provided expected results. The test material was classified as non-irritating.

Elaeis Guineensis (Palm) Oil

Undiluted palm oil and cosmetic lotions and creams containing 1.5-2.0% palm oil were minimally irritating to the eyes of rabbits, while one lotion containing 1.5% palm oil was moderately irritating.8 Hydrogenated palm oil suppositories were mildly irritating to rabbit eyes.

Gossypium Herbaceum (Cotton) Seed Oil

Cosmetic formulations containing 3.4-12.3% hydrogenated cottonseed oil were mildly irritating to the eyes of rabbits.10

Linum Usitatissimum (Linseed) Seed Oil

A mascara containing 9.4% linseed oil was tested for eye irritation potential in an in vitro study using neutral red release

(NRR), hen’s egg test on chorio-allantoic membrane (HET-CAM), and reconstituted human epithelial culture (REC) assays.40 For the NRR assay, the test product was diluted at 0%, 5%, 15%, 25%, 35%, and 50% in mineral oil. The NR50 of the test product was greater than 50% and the test product was considered slightly cytotoxic. In the HET-CAM assay, the score was 6.25 and the test product was considered moderately irritating when applied under a 67.1% solution in mineral oil. Finally in the REC assay, the cumulative simplified mean cytotoxicity index (SMCI) was calculated to be 0.25 and the test product was considered slightly cytotoxic when applied under a 66.9% solution in mineral oil. Overall, the study concluded that the mascara containing 9.4% linseed oil may be slightly irritating. 6

CIR Panel Book Page 15 Olea Europea (Olive) Fruit Oil

The ocular irritation potential of high purity olive oil was evaluated using in vivo and in vitro testing.41 In vivo, a Draize test was conducted using New Zealand rabbits. (The number of animals used was not specified.) Undiluted olive oil was not an ocular irritant in this test. Using human conjunctival epithelial cells in an in vitro study, olive oil did not induce cellular necrosis or apoptosis.

Oryza Sativa (Rice) Bran and Rice Germ Oil

A mixture of rice bran oil and rice germ oil, concentrations not stated, were not irritating to rabbit eyes.11 Undiluted rice bran oil was considered minimally irritating, and rice germ oil, concentration not stated, was not a primary irritant.

Ribes Nigrum (Black Currant) Seed Oil

A 50% dilution of an eye mask containing 0.2% black currant seed oil was tested in a HET-CAM assay.42 Two eye gels with vitamin E at 50% were used as reference products. The average score was 2.00, where a mean score of 0-4.9 considered

“practically none” for irritation potential.

Sesamum Indicum (Sesame) Seed Oil

Undiluted sesame oil was non- to minimally irritating to rabbit eyes, and a lipstick containing 10-11% sesame oil was not an ocular irritant.30

Triticum Vulgare (Wheat) Germ Oil

Undiluted wheat germ oil was, at most, a minimal ocular irritant, and 2% in a water emulsion was not irritating.13

Zea Mays (Corn) Oil

The ocular irritation potential of high purity corn oil was evaluated using in vivo and in vitro testing.41 In vivo, a Draize test was conducted using New Zealand rabbits. (The number of animals used was not specified.) Undiluted corn oil was not an ocular irritant in this test. Using human conjunctival epithelial cells in an in vitro study, corn oil did not induce cellular necrosis or apoptosis.

CARCINOGENICITY The safety of glycidol fatty acid esters in refined vegetable oils was assessed by IARC. Glycidol was determined to be a

Group2A (probably carcinogenic to humans) chemical while Glycidol Fatty Acid Esters was determined to be a Group 3 (not classifiable as to carcinogenicity to humans) chemical.43,44

The Federal Institute for Risk Assessment in Germany released a summary of their initial evaluation of the assessment of levels of glycidol fatty acid esters detected in refined vegetable fats.45 While acknowledging that the levels of glycidol that may be

CIR Panel Book Page 16 released from glycidol fatty acid esters are not known, the evaluation noted that glycidol is classified as probably carcinogenic to humans. The evaluation was based on findings of the German Chemical and Veterinary Test Agency (CVUA).

In a presentation by Weisshauer from the CVUA, the conversion of glycidol to 3-chloropropanediol was presented as an artifact of the analytical method, and it appeared to be the 3-chloropropanediol that was detected its indicative of the presence of glycidol.46 The levels of 3-chloropropanediol were negligible at the crude oil, degummed, neutralized, and bleached stages, but levels were significant at the deodorized stage.

CLINICAL ASSESSMENT OF SAFETY Edible oils are commonly believed to be safe for use on the skin.4 de Groot notes that no documentation exist to show that high quality edible lipids cause adverse reactions in normal individuals (except for potential comedogenicity).47 Very few reports of adverse reactions to cosmetic use of edible oils have been reported.

Irritation/Sensitization/Allergenicity Many edible oils are derived from foods that are recognized as potent food allergens. It has been shown that often an individual that is allergic to a food will generally not react to the refined oil.6 A prime example is peanut oil. While the safety of peanut oil is not being addressed in this assessment, it is being discussed here to demonstrate that although a food might cause allergic reactions, the oil usually does not. Peanuts are extremely allergenic to a large population, but reaction to the oil is rare. In its safety assessment on peanut (Arachis hypogaea) oil, the Expert Panel noted that the major concern associated with allergic reactions to peanuts is the protein.9 The protein does not partition into the refined oil, and therefore the oil is safe for use in cosmetics. Crevel et al. also concluded that chemically refined peanut oil is safe for the majority of peanut allergic individuals.6

They stated that “as peanut is acknowledged to be one of the most potent food allergens, it is reasonable to extrapolate the conclusions drawn up for peanut oil to other edible oils.” However, they concede that validated analytical methodology for establishing the protein content of oil is needed.

In support of the conclusions stated earlier, Crevel et al. also examined the allergenicity of some other oils. Very few instances of allergic reactions to other major edible oils have been reported. Even sesame oil, which differs from the other oils in that it is used as a flavorant and therefore is not as refined and expected to contain significantly more protein that the other edible oils, has had very few reports of allergic reaction. Additional studies demonstrating safety are summarized later in this section.16,48

Specific information on clinical dermal irritation and sensitization findings from previous CIR reports on edible oils are described below and are identified by italics. New clinical irritation and sensitization data is summarized in Table 7.

CIR Panel Book Page 17 Carthamus Tinctorius (Safflower) Oil

Cosmetic formulations containing 3-5% safflower oil were not irritating to humans in occlusive patch tests and were not primary irritants or sensitizers in repeated insult patch tests.15

Elaeis Guineensis (Palm) Oil

Palm oil, 15% in petrolatum or cosmetic formulations containing 1.0-2.0%, was not an irritant or sensitizer in clinical studies.8 Bar soap flakes, tested at dilutions that contained ≤ 2.13% palm kernel oil, were not irritating or sensitizing.

Gossypium Herbaceum (Cotton) Seed Oil

In a clinical patch test, the irritation potential of a cosmetic formulation containing 3.4% hydrogenated cottonseed oil was mildly low, and the severity of reaction to 10.4% hydrogenated cottonseed oil was acceptably low in a use study.10 Cosmetic formulations containing 10.6-20.86% hydrogenated cottonseed oil were not irritating or sensitizing. Patients that were hypersensitive to cottonseed proteins were not sensitive to cottonseed oil in a skin prick test.

Oryza Sativa (Rice) Bran Oil

Rice is generally regarded as hypoallergenic, although some case studies of allergic reactions to raw rice have been reported.11 In clinical testing, formulations containing 1.04-8.0% rice bran oil were not irritating or sensitizing, and formulations containing 1.04% rice bran oil were not photosensitizing. Hydrolyzed rice protein was not irritating to human subjects.

Persea Gratissima (Avocado) Oil

Avocado was not an irritant or sensitizers when human subjects were patch tested with cosmetic formulations containing

up to 10.7% avocado oil or in patch tests using 100% avocado oil.14

Sesamum Indicum (Sesame) Seed Oil

In clinical testing, undiluted sesame oil was not irritating.30 Cosmetic formulations containing 8-14.3% sesame oil were non- to essentially non-irritating. Prophetic patch testing with formulations containing 10-11% sesame oil were not irritating with or without UV light. Patients with contact allergy to sesame oil were patch tested, and most had positive reactions to sesamol, sesamin, and sesamolin.

Triticum Vulgare (Wheat) Germ Oil

In clinical testing, wheat germ oil was not an irritant or a sensitizer.13

Ocular Irritation Linum Usitatissimum (Linseed) Seed Oil The ocular irritation potential of a mascara containing 9.4% linseed oil was tested in 33 female subjects for 4 weeks.49 Of the 33 subjects, 16 were contact lens wearers and the remaining 17 were self-assessed sensitive eye non-contact lens wearers. One subject dropped out of the study for non-treatment related reasons. Subjects were evaluated with subjective questionnaires

CIR Panel Book Page 18 regarding ocular sensation following product use as well as with objective ophthalmic findings. Trace increases in palpebral conjunctival irritation were observed in only one subject, but this result was thought to be non-treatment related by the study investigators. No subjective irritation was reported and no adverse events were reported. The study concluded that the test material was clinically safe for use by contact lens wearers and self-assessed sensitive eye non-contact wearers.

Ribes Nigrum (Black Currant) Seed Oil An in-use 4 week study was conducted on an eye mask that contained 0.2% black currant seed oil (undiluted) in 52 subjects.50 Subjects were evaluated by an ophthalmologist and a dermatologist at baseline and at the end of the study. No adverse reactions were observed. The eye mask was considered ophthalmologist tested and safe for contact lens wearers.

Comedogenicity Ribes Nigrum (Black Currant) Seed Oil A comedogenicity study of an eye mask containing 0.2% black currant seed oil (undiluted) was performed on 6 subjects.51 The test material was applied with occlusive patches. The average score was 0.00 comedones/cm2. The eye mask was found to be non-comedogenic.

Case Studies Glycine Soja (Soybean) Oil

Seven patients with a history of immediate hypersensitivity reaction after the ingestion of soybeans were enrolled in a double-blind crossover study.48 The patients were first skin tested by the puncture method with a crude whole soybean extract, a partially hydrogenated oil, a non-hydrogenated oil, and a cold-pressed soybean oil. Olive oil from a retailer was used as a negative control. Since all 7 patients had negative skin tests to the oils and positive reactions to the crude soybean extract, they were challenged orally with capsules of each of the oils in random order on 4 separate days. None of the patients reacted to the oral challenges. The researchers remarked that while a reaction to the cold-pressed soybean oil did not occur in this study, cold-pressed oils may contain soybean protein and should be avoided.

The sera from 4 patients with known allergy to soybean was used to examine the allergenicity of soy oil proteins.21

Neither the IgE nor the IgG4 in the sera reacted to protein in the soy oil.

Helianthus Annuus (Sunflower) Oil

Two cases were reported of patients having anaphylactic reactions following ingestion of sunflower seeds.16 No reactions were seen upon oral or open challenge with refined or cold-pressed sunflower oils, both of which were shown to contain detectable amounts of protein. However, in a case report of a woman who had been desensitized to mugwort (a member of the

Compositae family) pollen for a year, but then had an anaphylactic reaction to sunflower (also a member of the Compositae family) seeds, it was found that she had a delayed positive reaction to sunflower oil in a skin prick test.52 Prick test results with 10

CIR Panel Book Page 19 control subjects were negative. In an oral challenge test, a delayed reaction was again observed, with symptoms occurring 2.25-8 h after administration.

Olea Europea (Olive) Fruit Oil

Throughout the literature, it is stated that sensitization to olive oil is considered rare. Case reports have been described, however, and generally involved patients with venous eczema, some type of dermatitis or lesion, or an occupational exposure.

Patch testing with olive oil produced positive reactions in most of these cases, and these results were usually regarded as allergenic. The concentrations of olive oil tested were not always given, but when stated, test concentrations giving positive results, ranged from 30-100%. In some cases, the constituents of olive oil were tested as well, but the results of that testing were negative.53-60

Kränke et al. investigated whether the reactions to olive oil were contact sensitization or irritation, using open and occlusive testing. They concluded that olive oil presented as a weak irritant rather than a contact sensitizer in the few case studies they observed. The capacity to produce an irritant result was increased using occlusive conditions.61 Zipprich and Hauser remarked that components capable of inducing an irritant reaction can form if the olive oil isn’t stored properly.62

Persea Gratissima (Avocado) Oil

A case study was reported in which a female subject had dermatitis around the eyes and earlobes.63 Patch testing with her sunscreen resulted in positive results. In subsequent patch testing of the individual ingredients, a positive reaction to undiluted avocado oil, but not to the active ingredient, was observed. Twenty controls subjects were used, and reactions to avocado oil were not seen.

Sesamum Indicum (Sesame) Seed Oil

A case study was reported in which a woman applied a Chinese ointment containing sesame oil, resulting in pruritic erythema, papules, and vesicles. 64 Patch testing was performed with the ointment and with the individual ingredients, including undiluted sesame oil. Both the ointment and sesame oil produced positive reactions on days 2, 3, 4, and 11. The other components did not cause a reaction. Results were negative in patch testing of sesame oil using 20 healthy subjects.

SUMMARY The oils derived from vegetable and fruit plants are composed of mono-, di-, and triglycerides, free fatty acids and other minor components, including natural antioxidants and fat-soluble vitamins. The percentage of chemical constituents and nutritional content of individual oil types is dependent on region where the oil plant is grown, individual cultivars, and plant genetics. Oils used in cosmetics are likely produced in the same manner as those used in the food industry. Oils may be expressed

CIR Panel Book Page 20 through mechanical or solvent extraction. The oils may undergo further refining to remove pigments, odors, unsaponifiable materials, and other undesirables.

It has been shown that often an individual that is allergic to a food will generally not react to the refined oil. The CIR

Expert Panel has found a general lack of clinical effects for edible oils that they have already reviewed; however, other researchers have raised concerns about the presence of residual proteins oils, such as peanut and soy. These ingredients may also contain aflatoxins, a metabolic products of certain molds that are carcinogenic to humans. The FDA action level for aflatoxin in foods is

20 ppb.

Of the oils described in this report, sunflower seed oil has the most reported uses in cosmetic and personal care products with a total of 1414 and is used at a maximum concentration of 96%. Oils are used in a wide variety of cosmetic products, including use in hair spray and other aerosolized products. None of the oils or the related counterparts described in this report were restricted from use in the European Union.

Oils not summarized in the animal toxicity section or clinical studies section of this report had no available data for review.

In dermal irritation studies in animals, Adansonia Digitata seed oil [baobab], hydrogenated cottonseed oil, rice bran oil, and rice germ oil were not irritating. Undiluted safflower oil was minimally irritating in rabbits, but it was not a primary irritant in guinea pigs. Undiluted palm oil, sesame oil, and wheat germ oil were practically non-irritating to minimally irritating in rabbits.

Safflower oil, palm oil, rice bran oil, rice germ oil, and wheat germ oil were non-sensitizing in animal studies. Rice bran oil, rice germ oil, and palm oil were not phototoxic in animals studies.

In animal ocular studies, Adansonia Digitata seed oil [baobab], olive oil, rice germ oil, black currant seed oil, 10-11% sesame seed oil, 2% wheat germ oil, and corn oil were non-irritating. Undiluted palm oil and palm oil at 2% were minimally irritating to rabbit eyes. Hydrogenated palm oil and 3.4% - 12.3% hydrogenated cottonseed oil were considered mildly irritating.

In a HET-CAM study, 9.4% linseed oil was slightly irritating. Undiluted rice bran oil and undiluted wheat germ oil were minimally irritating to eyes, while undiluted sesame oil was non- to minimal ocular irritants.

Glycidol and glycidol fatty acid esters, possible constituents in refined vegetable oils, were determined to be Group 2A

(probably carcinogenic to humans) and Group 3 (not classifiable as to carcinogenicity to humans) chemicals, respectively, by

IARC.

Edible oils are believed to be safe for use on the skin and very few reports of adverse reactions have been reported. The proteins that are responsible for allergenic responses in individuals with food allergies do not partition into refined oils.

CIR Panel Book Page 21 In previously reviewed oils, safflower oil, palm oil, hydrogenated cottonseed oil, rice bran oil, avocado oil, sesame oil, and wheat oil were non-irritating and/or non-sensitizing in human studies. In many of the oils found in this report, no irritation and/or sensitization reactions were observed in human repeated insult patch tests.

In clinical studies, 0.2% black currant seed and 9.4% linseed oil were not ocular irritants. Black currant seed oil at 0.2% was also non-comedogenic. Cases of contact allergy have been reported for soybean oil, sunflower oil, olive oil, avocado oil, and sesame seed oil.

CIR Panel Book Page 22 FIGURES AND TABLES

H2C OCR

HC OCR'

" H2C OCR

-OCR, -OCR', and -OCR" may be the same or diff erent f atty acid radicals.

Figure 1. General structure of fats and oils.1

CIR Panel Book Page 23 -

Crude Oil

Water

Degummed Oil Lecithin Sludge

Alkali

Deodorization Salad Oil Alkali Refined Oil Soap Stock

Activated Earth Deodorization Salad Oil Bleached Oil

H2, Catalyst

Winterization & Deodorization Partially Deodorization Salad and Cooking Oil Hydrogenated Oil Cooking Oil

Deodorization Other Fatty Oil

Deodorization Shortening Blended Oils Stock

Deodorization

Margarine Stock

Figure 2. Basic oil refinement flowchart.3

CIR Panel Book Page 24 Table 1. Edible oils and their derivatives.* Vegetable (Olus) Oil (CAS No. 68956-68-3) Helianthus Annuus (Sunflower) Seed Oil (CAS No. 8001-21-6) Brassica Napus Seed Oil [Rapeseed] Hydrogeanted Vegetable Oil (CAS No. 68334-28-1) Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables Brassica Oleracea Acephala Seed Oil [Kale] Major Oils Hydrogenated Sunflower Seed Oil Brassica Oleracea Italica (Broccoli) Seed Oil Brassica Campestris (Rapeseed) Seed Oil (CAS No. 8002-13-9) Sunflower Seed Acid (CAS No. 84625-38-7) Camelina Sativa Seed Oil [False Flax] Brassica Campestris (Rapeseed) Oil Unsaponifiables Olea Europea (Olive) Fruit Oil (CAS No. 8001-25-0) Hydrogenated Camelina Sativa Seed Oil Hydrogenated Rapeseed Oil (CAS No. 84681-71-0) Hydrogenated Olive Oil Camellia Japonica Seed Oil Potassium Rapeseedate Hydrogeanted Olive Oil Unsaponifiables Camellia Kissi Seed Oil [Tea] Rapeseed Acid Olive Acid (CAS No. 92044-96-7) Camellia Oleifera Seed Oil [Tea Seed] Sodium Rapeseedate Olea Europaea (Olive) Husk Oil Hydrogenated Camellia Oleifera Seed Oil Canola Oil (CAS No. 8002-13-9; 120962-03-0) Olea Europaea (Olive) Oil Unsaponifiables (CAS No. 156798-12-8) Camellia Sinensis Seed Oil Canola Oil Unsaponifiables Potassium Olivate (CAS No. 68154-77-8) Carica Papaya Seed Oil [Papaya] Hydrogenated Canola Oil Sodium Olivate (CAS No. 64789-88-6) Caryocar Brasiliense Fruit Oil [Pequi] Carthamus Tinctorius (Safflower) Seed Oil (CAS No. 8001-23-8) Oryza Sativa (Rice) Bran Oil (CAS No. 68553-81-1; 84696-37-7) Chenopodium Quinoa Seed Oil [Quinoa] Hydrogenated Safflower Seed Oil Oryza Sativa (Rice) Germ Oil Citrullus Lanatus (Watermelon) Seed Oil Potassium Safflowerate Rice Bran Acid (CAS No. 93165-33-4) Citrus Aurantifolia (Lime) Seed Oil Safflower Acid Hydrogenated Rice Bran Oil Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables Sodium Safflowerate Oryza Sativa (Rice) Seed Oil Hydrogenated Lime Seed Oil Elaeis Guineensis (Palm) Oil (CAS No. 8002-75-3) Sesamum Indicum (Sesame) Seed Oil (CAS No. 8008-74-0) Hydrogenated Lime Seed Oil Unsaponifiables CIR Elaeis Guineensis (Palm) Kernel Oil (CAS No. 8023-79-8) Hydrogenated Sesame Seed Oil Citrus Aurantium Dulcis (Orange) Seed Oil

Panel Hydrogenated Palm Oil (CAS No. 8033-29-2; 68514-74-9) Sesamum Indicum (Sesame) Oil Unsaponifiables Citrus Aurantium Dulcis (Orange) Seed Oil Unsaponifiables Hydrogenated Palm Kernel Oil (CAS No. 68990-82-9; 84540-04-5) Sodium Sesameseedate Hydrogenated Orange Seed Oil

Book Palm Kernel Acid Sesamum Indicum (Sesame) Seed Butter Hydrogenated Orange Seed Oil Unsaponifiables Elaeis Guineensis (Palm) Butter (CAS No. 8002-75-3) Zea Mays (Corn) Oil (CAS No. 8001-30-7) Citrus Grandis (Grapefruit) Seed Oil

Page Elaeis Oleifera Kernel Oil Zea Mays (Corn) Germ Oil Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables Elaeis (Palm) Oil Zea Mays (Corn) Oil Unsaponifiables Citrus Paradisi (Grapefruit) Seed Oil 25 Palm Acid Corn Acid (CAS No. 68308-50-9) Hydrogenated Grapefruit Seed Oil Hydrogenated Palm Acid Potassium Cornate (CAS No. 61789-23-9) Hydrogenated Grapefruit Seed Oil Unsaponifiables Potassium Palmate Minor Oils Citrus Limon (Lemon) Seed Oil (CAS No. 85085-28-5) Potassium Hydrogenated Palmate Actinidia Chinensis (Kiwi) Seed Oil Coix Lacryma-Jobi (Job's Tears) Seed Oil Potassium Palm Kernelate Adansonia Digitata Oil [Baobab] Crambe Abyssinica Seed Oil [Abyssinian Mustard] Sodium Hydrogenated Palmate Adansonia Digitata Seed Oil Cucumis Sativus (Cucumber) Seed Oil (CAS No. 70955-25-8) Sodium Palmate (CAS No. 61790-79-2) Hydrogenated Adansonia Digitata Seed Oil Cucurbita Pepo (Pumpkin) Seed Oil (CAS No. 8016-49-7) Sodium Palm Kernelate (CAS No. 61789-89-7) Amaranthus Hypochondriacus Seed Oil [Amaranth] Hydrogenated Pumpkin Seed Oil Glycine Soja (Soybean) Oil (CAS No. 8001-22-7) Arctium Lappa Seed Oil [Burdock] Cynara Cardunculus Seed Oil [Artichoke] (CAS No. 923029-60-1) Glycine Soja (Soybean) Oil Unsaponifiables (CAS No. 91770-67-1) Argania Spinosa Kernel Oil [Argan] Euterpe Oleracea Fruit Oil [Acai] Hydrogenated Soybean Oil (CAS No. 8016-70-4) Hydrogenated Argania Spinosa Kernel Oil Fragaria Ananassa (Strawberry) Seed Oil Soy Acid (CAS No. 68308-53-2) Astrocaryum Murumuru Seed Butter [Murumuru] Fragaria Chiloensis (Strawberry) Seed Oil Potassium Soyate Sodium Astrocaryum Murumuruate Fragaria Vesca (Strawberry) Seed Oil Sodium Soyate Avena Sativa (Oat) Kernel Oil Fragaria Virginiana (Strawberry) Seed Oil Gossypium Herbaceum (Cotton) Seed Oil (CAS No. 8001-29-4) Bassia Butyracea Seed Butter Garcinia Indica Seed Butter [Kokum] Cottonseed Acid (CAS No. 68308-51-0) Bassia Latifolia Seed Butter [Mahwa] Guizotia Abyssinica Seed Oil [Ramtil] Hydrogenated Cottonseed Oil (CAS No. 68334-00-9) Borago Officinalis Seed Oil [Borage] (CAS No. 225234-12-8) Hippophae Rhamnoides Oil [Sea-Buckthorn] * previously reviewed ingredients are in bold and italics

Table 1. Edible oils and their derivatives.* Hippophae Rhamnoides Fruit Oil [Sea-Buckthorn] Hydrogenated Passiflora Edulis Seed Oil Hydrogenated Raspberry Seed Oil Hippophae Rhamnoides Seed Oil [Sea-Buckthorn] Perilla Ocymoides Seed Oil [Perilla] Sclerocarya Birrea Seed Oil [Marula] Irvingia Gabonensis Kernel Butter [Dika] (CAS No. 192230-28-7) Persea Gratissima (Avocado) Oil (CAS No. 8024-32-6) Silybum Marianum Seed Oil [Thistle] Limnanthes Alba (Meadowfoam) Seed Oil (CAS No. 153065-40-8) Hydrogenated Avocado Oil Solanum Lycopersicum (Tomato) Seed Oil Hydrogenated Meadowfoam Seed Oil Persea Gratissima (Avocado) Butter Solanum Lycopersicum (Tomato) Fruit Oil Persea Gratissima (Avocado) Oil Unsaponifiables (CAS No. 91770- Linum Usitatissimum (Linseed) Seed Oil (CAS No. 8001-26-1) 40-0) Theobroma Cacao (Cocoa) Seed Butter (CAS No. 8002-31-1) Linseed Acid (CAS No. 68424-45-3) Sodium Avocadoate Sodium Cocoa Butterate Theobroma Grandiflorum Seed Butter [Cupuacu] (CAS No. Luffa Cylindrica Seed Oil [Luffa] Plukenetia Volubilis Seed Oil [Sacha Inchi] 394236-97-6) Lupinus Albus Seed Oil [White Lupine] Prunus Armeniaca (Apricot) Kernel Oil (CAS No. 72869-69-3) Sodium Theobroma Grandiflorum Seedate Lupinus Albus Oil Unsaponifiables Hydrogenated Apricot Kernel Oil Torreya Nucifera Seed Oil [Kaya] Triticum Vulgare (Wheat) Germ Oil (CAS No. 8006-95-9; 68917- Lycium Barbarum Seed Oil [Goji Berry] Hydrogenated Apricot Kernel Oil Unsaponifiables 73-7) Mangifera Indica (Mango) Seed Oil Prunus Armeniaca (Apricot) Kernel Oil Unsaponifiables Hydrogenated Wheat Germ Oil Mangifera Indica (Mango) Seed Butter Prunus Avium (Sweet Cherry) Seed Oil Hydrogenated Wheat Germ Oil Unsaponifiables Sodium Mangoseedate Prunus Domestica Seed Oil [Prune/Plum] Triticum Aestivum (Wheat) Germ Oil Morinda Citrifolia Seed Oil [Noni] Prunus Persica (Peach) Kernel Oil (CAS No. 8002-78-6; 8023-98-1) Triticum Vulgare (Wheat) Germ Oil Unsaponifiables Moringa Oleifera Seed Oil [Ben] Hydrogenated Peach Kernel Oil Wheat Germ Acid (CAS No. 68938-32-9) CIR Moringa Pterygosperma Seed Oil Punica Granatum Seed Oil [Pomegrante] Vaccinium Corymbosum (Blueberry) Seed Oil

Panel Oenothera Biennis (Evening Primrose) Oil Hydrogenated Punica Granatum Seed Oil Vaccinium Macrocarpon (Cranberry) Seed Oil Hydrogenated Evening Primrose Oil Pyrus Malus (Apple) Seed Oil Hydrogenated Cranberry Seed Oil

Book Orgibnya Cohune Seed Oil [Cohune] Ribes Nigrum (Black Currant) Seed Oil (CAS No. 97676-19-2) Vaccinium Myrtillus Seed Oil [Bilberry] (CAS No. 1161921-09-0) Orbignya Oleifera Seed Oil [Babassu] (CAS No. 91078-92-1) Hydrogenated Black Currant Seed Oil Vaccinium Vitis-Idaea Seed Oil [Ligonberry]

Page Orbignya Speciosa Kernel Oil [Babassu] Ribes Rubrum (Currant) Seed Oil Vanilla Planifolia Fruit Oil [Vanilla] (CAS No. 8024-06-4) Babassu Acid Rosa Canina Fruit Oil [Dog Rose] Vitis Vinifera (Grape) Seed Oil (CAS No. 8024-22-4)

26 Potassium Babassuate Hydrogenated Rosa Canina Fruit Oil Sodium Grapeseedate Sodium Babassuate Rubus Chamaemorus Seed Oil [Cloudberry] Hydrogenated Grapeseed Oil Passiflora Edulis Seed Oil [Passion Fruit] (CAS No. 87676-26-1) Rubus Idaeus (Raspberry) Seed Oil * previously reviewed ingredients are in bold and italics

Table 2. Previously reviewed oil and fatty acid ingredients.

Ingredients Publication Date Conclusion Oil Ingredients

JACT 4(5):171-197, 1985; Safe Carthamus Tinctorius (Safflower) Seed Oil (CAS No. 8001-23-8) Re-reviewed, not reopened IJT 25(2):1-89, 2006 Elaeis Guineensis (Palm) Oil (CAS No. 8002-75-3) Elaeis Guineensis (Palm) Kernel Oil (CAS No. 8023-79-8) IJT 19(S2):7-28, 2000 Safe Hydrogenated Palm Oil (CAS No. 8033-29-2; 68514-74-9) Hydrogenated Palm Kernel Oil (CAS No. 68990-82-9; 84540-04-5) Gossypium Herbaceum (Cotton) Seed Oil (CAS No. 8001-29-4) Cottonseed Acid (CAS No. 68308-51-0) IJT 20(S2):21-29, 2001 Safe Hydrogenated Cottonseed Oil (CAS No. 68334-00-9) Oryza Sativa (Rice) Bran Oil (CAS No. 68553-81-1; 84696-37-7) Oryza Sativa (Rice) Germ Oil IJT 25(S2):91-120, 2006 Safe Rice Bran Acid (CAS No. 93165-33-4) Sesamum Indicum (Sesame) Seed Oil (CAS No. 8008-74-0) Hydrogenated Sesame Seed Oil JACT 12(3):261-277, 1993; Safe Sesamum Indicum (Sesame) Oil Unsaponifiables Amended Final Report, 2009 CIR Sodium Sesameseedate

Panel Zea Mays (Corn) Oil (CAS No. 8001-30-7) Zea Mays (Corn) Germ Oil Book Zea Mays (Corn) Oil Unsaponifiables Final Report, 2008 Safe Corn Acid (CAS No. 68308-50-9) Page Potassium Cornate (CAS No. 61789-23-9)

27 JEPT 4(4):93-103, 1980; Persea Gratissima (Avocado) Oil (CAS No. 8024-32-6) Re-reviewed, not reopened IJT 22(1):1-35, 2003 Safe JEPT 4(4):33-45, 1980; Triticum Vulgare (Wheat) Germ Oil (CAS No. 8006-95-9; 68917-73-7) Re-reviewed, not reopened IJT 22(1):1-35, 2003 Safe Fatty Acids Arachidonic Acid (CAS No. 506-32-1) JACT 12 (5):481-559, 1993 Insufficient data Hydroxystearic Acid (CAS No. 106-14-9) IJT 18(S1):1-10, 1999 Safe Lauric Acid (CAS No. 143-07-7) Myristic Acid (CAS No. 544-63-8) JACT 6(3):321-401, 1987; Safe Oleic Acid (CAS No. 112-80-1) Re-reviewed, not reopened IJT 25(2):1-89, 2006 Palmitic Acid (CAS No. 57-10-3) Stearic Acid (CAS No. 57-11-4)

Table 2. Previously reviewed oil and fatty acid ingredients (continued). Ingredients Publication Date Conclusion Glyceryl Triesters Trilaurin Triarachidin Tribehenin Tricaprin Tricaprylin Trierucin Triheptanoin Triheptylundecanoin Triisononanoin Triisopalmitin Triisostearin Trilinolein IJT 20 (S4):61-94, 2001 Safe Trimyristin Trioctanoin Triolein Tripalmitin CIR Tripalmitolein

Panel Triricinolein Tristearin

Book Triundecanoin Glyceryl Triacetyl Hydroxystearate

Page Glyceryl Triacetyl Ricinoleate Glyceryl Stearate Diacetate 28

Table 3. Fatty acid composition.

Fully Corn Cotton Palm Palm Kernel Rapeseed Hydrogenated Safflower Sesame Seed Fatty Acids Oil28,65,66 * Seed Oil10 Olive Oil3 Oil8 Oil8 Oil3 Rapeseed Oil2 Canola Oil2 Seed Oil15,67 Oil7,30 Caproic (C6) 0.3 Caprylic (C8) 4.4 Capric (C10) 3.7 Lauric (C12) 0.2 48.3 Myristic (C14) 0.1 - 1.7 2 Trace 1.1 15.6 < 1.0 < 0.2 <0.5 Myristoleic (C14:1) Palmitic (C16) 8-12; 8-16.5 21 7.5 - 20 44 7.8 1.5 - 3 3-5.0 < 6.0 2 7.0 - 12.0 Palmitoleic (C16:1) 0.2 - 1.6 0.3 - 3.5 0.1 < 1.0 <0.5 Heptadecanoic (C17:0) Stearic (C18) 2.5 - 4.5; 0-4 Trace 0.5 - 3.5 4.5 2 0.7 - 1.3 38-42 < 2.5 3.5 - 6.0 Oleic (C18:1) 19 – 49; 20-43 30 53 - 86 39.2 15.1 12.1 - 57.4 1 > 50 26 35 - 50 Linoleic (C18:2) 34 – 62; 50-66 45 3.5 - 20 10.1 2.7 11.4 - 22.1 < 1.0 < 40.0 68 35 - 50 Linolenic (C18:3) 0-2 0 - 1.5 0.4 8.3 - 12.5 < 14 Trace <1.0

CIR Arachidic (C20) 1 Trace Trace 0.4 8-10.0 < 1.0 Trace <1.0 Eicosenoic (C20:1) 1 5.6 - 3.1 < 1.0 < 2.0 <0.5 Panel Eicosadienoic (C20:2) Behenic (C22) Trace 42-50 < 0.5 <0.5 Book Erucic (C22:1) 1 - 58.6 < 1.0 < 2.0 Docosadienoic (C22:2) Page Docosahexaenoic (C22:6) Trace 1-2.0 < 0.2

29 Lignoceric (C24) Arachidonic (C20:4n6) Arachidontrienoic

< C14 = < Trace of 0.1; C24:1 = components Others 0.2 < 0.2 below C14 Oleic/Linoleic Saturated, General

*Shadowing identifies previously reviewed ingredients.

Table 3. Fatty acid composition (continued.)

Soybean Sunflower Acai Amaranth Apricot Artichoke Avocado Babassu Ben Camelina (False Fatty Acids Oil3 Seed Oil3 Oil68 Oil69 Kernel Oil3 Oil70 Oil3 Oil3 Oil71 Flax) Seed Oil72 Caproic (C6) Caprylic (C8) 4 to 8 Capric (C10) 4 to 8 Lauric (C12) 44 - 47 Myristic (C14) 15 - 20 Trace Myristoleic (C14:1) Palmitic (C16) 5.0 - 7.2 22 19 - 20 Small quantity 12 13-17 6 to 9 9.3 7.8 Palmitoleic (C16:1) 2 3 - 5.1 Heptadecanoic (C17:0) Stearic (C18) 2.0 - 6.5 2 3 3 3 to 5 7.4 2.96 Oleic (C18:1) 11.5 - 60.0 14.7 - 37.2 60 22 - 26 25 67-72 10 to 12 65.7 16.77 Linoleic (C18:2) 25 - 63.1 51.5 - 73.5 12 46 - 50 60 10 to 12 1 to 3 23.08 Linolenic (C18:3) 2.9 - 12.1 Trace - 0.3 Trace 31.2

CIR Arachidic (C20) 0.3 - 1 2.5 Eicosenoic (C20:1) 11.99 Panel Eicosadienoic (C20:2) Behenic (C22) 8.6 Book Erucic (C22:1) 2.8 Docosadienoic (C22:2) Page Docosahexaenoic (C22:6) Trace

30 Lignoceric (C24) Arachidonic (C20:4n6) Arachidontrienoic

Others 3.4 Oleic/Linoleic 90-93 Saturated, General 12 - 13.5

Table 3. Fatty acid composition (continued.)

Cocoa Cupuacu Mango Seed Cohune Cranberry Cucumber Seed Grape Linseed Seed Marula Meadowfoam Fatty Acids Butter3 Oil3 Seed Oil73 Oil74 Butter75 Seed Oil3 Oil3 Oil3** Oil76 Seed Oil3 Caproic (C6) Caprylic (C8) 7.5 Capric (C10) 6.5 Lauric (C12) 46.5 Myristic (C14) 16 Trace Myristoleic (C14:1) Palmitic (C16) 24-29 9.5 4.0 - 6 9.0 - 13 7.2 7-9.5 5.5 5.0-8 9 to 12 Palmitoleic (C16:1) 0.1 0.05 - 0.15 Heptadecanoic (C17:0) 0.2 Stearic (C18) 34-36 3 6.0 - 9 30.8 3.5-5.5 3.5 33-48 5 to 8 Oleic (C18:1) 30-40 10 20 - 24 14 - 20 43.9 14-44 19.1 35-50 70 - 78 Linoleic (C18:2) 2.4 1 32 - 37 60 - 68 4.6 46-74 15.3 4.0-8 4.0 - 7.0 Linolenic (C18:3) 30 - 35 < 1 Trace 57 0.1 - 0.6

CIR Arachidic (C20) 11 1.0-7 0.3 - 0.7 Eicosenoic (C20:1) 0.1 - 0.5 52 - 77 Panel Eicosadienoic (C20:2) Behenic (C22) Book Erucic (C22:1) 0.1 - 0.5 8.0 - 29 Docosadienoic (C22:2) 7.0 - 20 Page Docosahexaenoic (C22:6)

31 Lignoceric (C24) Arachidonic (C20:4n6) Arachidontrienoic

Others Oleic/Linoleic Saturated, General

**As Mango Kernel Fat

Table 3. Fatty acid composition (continued.)

Peach Rice Strawberry Murumuru Kernel Perilla Quinoa Ramtil/Niger Germ Seed Oil80 Watermelon Wheat Germ Fatty Acids Seed Butter77 Oil78 Oil3 Seed Oil79 Oil3 Oil11 *** Seed Oil81 Oil13,27 Baobab Oil82,83 Caproic (C6) Caprylic (C8) 1.85 Capric (C10) 1.85 Lauric (C12) 47.46 Myristic (C14) 26 0.2 6.92 Myristoleic (C14:1) Palmitic (C16) 6.28 2.0 - 7 9.9 - 11 5.0-13 9.28 8.0 - 13.0 11.0 - 16 18-30 Palmitoleic (C16:1) 0.1 4.41 < 1.0 1 Heptadecanoic (C17:0) Stearic (C18) 2.65 0.5 - 3.5 0.7 - 0.8 2.0-11 7.91 8.0 - 12.0 1.0 - 6 2-8 Oleic (C18:1) 12.56 55 - 70 14-23 22 - 24.5 6.0-40 17.81 16.5 - 19.5 15.0 - 30.0 8.0 - 30 30-40 Linoleic (C18:2) 2.87 22 - 33 16 50.2 - 56 45-77 16.22 28.5 - 41.5 55.0 - 65.0 44 - 65 24-34 Linolenic (C18:3) < 1 63-70 5.4 - 7 15.56 33.5 - 36.5 < 1.0 4.0 - 10 1-3

CIR Arachidic (C20) 0.7 3.08 < 1.0 Eicosenoic (C20:1) < 1.0 Panel Eicosadienoic (C20:2) Behenic (C22) < 1.0 Book Erucic (C22:1) Docosadienoic (C22:2) Page Docosahexaenoic (C22:6) < 2.0 2 max

32 Lignoceric (C24) Arachidonic (C20:4n6) 5.48 Arachidontrienoic 5.21

0 - 1.2 C20-22 Saturated Others 5.5 - 8.5 < 1.0 acids Oleic/Linoleic Saturated, General 6.0-12 ***Reported as Fragaria Ananassa (Strawberry) Seed Oil.

Table 3. Fatty acid composition (continued.)

Camellia Rice Bran Cherry Kernel Argan Borage Oleifera Papaya Lime Seed Orange Seed Grapefruit Pumpkin Seed Fatty Acids Oil84 Oil85,86 Oil87,88 Oil89,90 Seed Oil91,92 Seed Oil93,94 Oil95,96 Oil97,98 Seed Oil99,100 Oil101,102 Caproic (C6) Caprylic (C8) Capric (C10) Lauric (C12) 1.5 Myristic (C14) 1 1 Myristoleic (C14:1) Palmitic (C16) 14 4-10 10-15 9-13 6.1-15 8-18 20-30 14-22 18-30 10-16 Palmitoleic (C16:1) 2 Heptadecanoic (C17:0) Stearic (C18) 2 1-4 5-6.5 3-5 0.8-2 2-6 3-8 2-6 2-8 3-7 Oleic (C18:1) 45 23-55 45-55 10-22 72-87 60-77 20-38 26-35 20-38 18-38 Linoleic (C18:2) 34 30-55 28-36 33-46 5.3-14.3 3-25 30-45 35-45 30-48 40-62 Linolenic (C18:3) 1 13 18-25 0.8 5-15 2-6 2-6 1

CIR Arachidic (C20) 2 2 0.5 Eicosenoic (C20:1) 2-6 2 Panel Eicosadienoic (C20:2) Behenic (C22) Book Erucic (C22:1) 1-3.5 Docosadienoic (C22:2) Page Docosahexaenoic (C22:6)

33 Lignoceric (C24) Arachidonic (C20:4n6) Arachidontrienoic α-Linolenic (C18:3) = α-Linolenic Eleostearic 0.4%; (C18:3) = (C18:3 conj) = γ-Linolenic 2%; Others 10% = 1-3.5% Oleic/Linoleic Saturated, General

Table 3. Fatty acid composition (continued.)

Cranberry Evening Seed Primrose Plum Blackcurrant Red Raspberry Moringa Fatty Acids Oil103,104 Oil105,106 Oil107,108 Seed Oil109,110 Seed Oil111,112 Oil113,114 Caproic (C6) Caprylic (C8) Capric (C10) Lauric (C12) Myristic (C14) Myristoleic (C14:1) Palmitic (C16) 5-5.4 4-10 4-9 6-10 2-2.3 5-9 5-9Palmitoleic (C16:1) 1 1.5-3 Heptadecanoic (C17:0) Stearic (C18) 1 2-4 3 1-4 0.9-1 3-8 Oleic (C18:1) 24 5-12 60-80 9-16 10.9-11 65-80 Linoleic (C18:2) 35 60-85 15-25 40-50 52.6-53 1.5-5 Linolenic (C18:3) 1 31.9-32 1-1.5

CIR Arachidic (C20) 1 2-5 Eicosenoic (C20:1) 3 2.5-4 Panel Eicosadienoic (C20:2) Behenic (C22) 1 8 Book Erucic (C22:1) 1 3 Docosadienoic (C22:2) Page Docosahexaenoic (C22:6)

34 Lignoceric (C24) Arachidonic (C20:4n6) Arachidontrienoic α-Linolenic (C18:3) = 11- 17% γ-Linolenic = α-Linolenic 11-14% α-Linolenic (C18:3) = 1% Stearidonic (C18:3) = γ-Linolenic = 7- (18:4) = 2- Others 34-35% 12% 2.5% Oleic/Linoleic Saturated, General

Table 4. Chemical properties.

Properties and Constituents Canola Oil2 Cottonseed Oil2,3 Olive Oil3 Palm Oil2,3 Palm Kernel Oil2,3 Rapeseed Oil3 Almost colorless to yellow, greenish, or Pale yellow to deep Appearance Light yelllow oil Dark red-brown oil brown in color orange in color Nearly colorless Specific gravity 0.914-0.918 0.921-0.925 (40◦C) Refractive index 1.465-1.467 (40◦C) 1.469-1.484 1.453-1.458 (40◦C) Iodine value 110-126 90-113 64-88; refined 75-94 44-58 14-33 81-112 185-212; refined 184- Saponification value 178-193 180-198 186 195-205 245-255 168-192

Peroxide value (meq/kg) 10 max 10 max 20 max (refined) 10 max 10 max Melting point (◦C) 25-50 25-30 Unsaponifiable matter (%) 1.5 max 1.5 max 0.6-1.2; 1.5 max refined 0.2-0.8 1.5 max 0.5 - 2

CIR 0.1 max (as oleic acid); 0.1 max (as oleic 0.1 max (as oleic acid); 0.07 max (as lauric Panel Free fatty acids (%) 0.05 max (as oleic acid) acid)## 0.6-1.4; 0.3 max refined 0.09 (as palmitic acid) acid) 1 Lead (mg/kg) 0.1 max 0.1 max 0.1 max 0.1 mg/kg max Book Acid value Page Properties and Hydrogenated Constituents Rapeseed Oil2 Safflower Oil2 Soybean Oil2,3 Sunflower Oil2,3 Apricot Oil3 Avocado Oil3 35

Appearance White waxy solid Light yellow oil Light amber oil Light amber oil

Specific gravity 0.894-0.899 (60◦C) 0.923 0.910-0.916

Refractive index 1.4597-1.4745 (at 25◦C) 1.4672-1.4722 1.461-1.465 Iodine value 4 max 135-150 120.9-151.4 128-144 81-123 71-95 Saponification value 188-194 191 177-198

Peroxide value (meq/kg) 2.0 max 10 max 10 max 10 max Melting point (◦C) 0 Unsaponifiable matter (%) 1.5 max 0.3-0.6 0.3-0.5

Free fatty acids (%) 2.0 max (as oleic acid) 0.1 max (as oleic acid) 0.05-0.7 0.1 max (as oleic acid) Lead (mg/kg) 0.1 max 0.1 max 0.1 max 0.1 max Acid value

Table 4. Chemical properties (continued).

Properties and Cranberry Seed Constituents Babassu Oil3 Cocoa Oil3 Oil3,73 Grape Seed Oil3 Linseed Oil3 Mango Oil3

Pale yello to ivory Appearance Light green cream color Specific gravity 0.916-0.918 (15◦C) 0.950-0.998 0.923 0.91-0.93 0.927-0.931 (20◦C) 0.91 Refractive index 1.449-1.451 (40◦C) 1.453-1.458 1.470-1.476 1.4786-1.4815 1.456 Iodine value 14-18 35-40 150.1 125-143 170-204 32-93

Saponification value 247-251 190-200 176-206 189-196 190-195 Peroxide value (meq/kg) < 15 Melting point (◦C) 33.5 0 34-43 Unsaponifiable matter (%) 0.5-1.5 0.8-2.9 CIR Panel

Free fatty acids (%) 5 Book Lead (mg/kg) Acid value Page

Properties and Strawberry Seed Watermelon Seed 36 Constituents Murumuru Butter3,77 Peach Kernel Oil3,78 Ramtil/Niger Oil3 Oil3,80 Oil3,81 Baobab Oil82,83

Pale brown waxy solid Pale yellow with a Pale to golden yellow Appearance at room temperature Pale yellow (refined) bluish tint Light golden liquid Pale yellow 0.910-0.920 (20◦C) Specific gravity 0.890-0.910 (25◦C) refined 0.910-0.928 0.95 0.8930-0.9166

Refractive index 1.467-1.471 1.4668 Iodine value 15 max 90-115 (refined) 126-139 113-123 65-95 Saponification value 270-350 180-195 193-195 190-210 Peroxide value (meq/kg) 20.0 max 5.0 max (refined) < 15 < 5.0 5.0-10 Melting point (◦C) 25-37 Unsaponifiable matter (%) 0.5-1 2.0 max (as oleic Free fatty acids (%) 12.56 (as oleic acid) 0.4-3 < 5.0 (as oleic acid) acid) Lead (mg/kg) Acid value 27

Table 4. Chemical properties (continued).

Cherry Kernel Camellia Oleifera Properties and Constituents Rice Bran Oil84,115 Oil85,86 Corn Oil65,66 Argan Oil87,88 Borage Oil89,90 Seed Oil91,92

Clear, bright golden Clear, pale yellow- Clear, pale yellow or Appearance Light golden yellow Clear light yellow yellow Yellow golden “water white” Specific gravity 0.916-0.922 (15.5◦C) 0.905-0.925 (20◦C) 0.920-0.928 (15.5◦C) 0.908-0.918 (20◦C) 0.918-0.928 (20◦C) Refractive index 1.470-1.473 (20◦C) 1.463-1.480 (20◦C) 1.472-1.476 (20◦C) 1.474-1.479 (20◦C) Iodine value 92-115 90-115 103-128 95 130-155 80-94

Saponification value 180-195 105-135 185-195 184-194 188-196

Peroxide value (meq/kg) 10.0 max 10.0 max 10.0 max 10.0 max 10.0 max 10.0 max Melting point (◦C)

Unsaponifiable matter (%) 1.5 max CIR

Panel Free fatty acids (%) 1.0 (as oleic acid) 0.5% max Lead (mg/kg) Book Acid value 1.0 max 0.2 max 3-4 1.0 max 1.0 max Page

Grapefruit Seed Pumpkin Seed Cranberry Seed 37 Properties and Constituents Papaya Seed Oil93,94 Lime Seed Oil95,96 Orange Seed Oil97,98 Oil99,100 Oil101,102 Oil103,104

Appearance Pale yellow Clear yellow Clear, light yellow Clear yellow Dark green

Specific gravity 0.910-0.920 (20◦C)

Refractive index 1.466-1.475 (20◦C) Iodine value 65-100 90-110 80-125 110-330 140-180 Saponification value 185-200 174-197 170-200

Peroxide value (meq/kg) 10.0 max 5.0 max 5-10 5-10 5.0 max 5.0 max Melting point (◦C)

Unsaponifiable matter (%) 1.5

Free fatty acids (%) 0.8-3 0.5 (as oleic acid) 1.5 ( as oleic) 1.0 (as oleic acid) Lead (mg/kg) Acid value 1.0 max 0.8 max 1.0 max 2.0 max 28

Table 4. Chemical properties (continued).

Evening Primrose Blackcurrant Seed Red Raspberry Properties and Constituents Oil105,106 Plum Oil107,108 Oil109,110 Seed Oil111,112 Moringa Oil113,114

Appearance Light yellow Specific gravity 0.920-0.930 (20◦C) 0.908 (20◦C) Refractive index 1.475-1.480 (20◦C) Iodine value 145-165 90-108 145-185 175-195

Saponification value 180-195 180-200 192

Peroxide value (meq/kg) 10.0 max 10.0 max 1-10 5.0 max 10.0 Melting point (◦C)

Unsaponifiable matter (%) CIR 2.0 max (as oleic 1.5 max (as oleic Panel Free fatty acids (%) acid) 0.2 acid) 2.0 max (as oleic acid) Lead (mg/kg)

Book Acid value 1-2 3 Page

Table 5a. Frequency of use according to duration and exposure. NR = Not reported to VCRP or Council. NS = Not yet surveyed. Conc. of No. of Uses Conc. of Use No. of Uses Conc. of Use No. of Uses Conc. of Use No. of Uses No. of Uses Conc. of Use No. of Uses Conc. of Use Use (2010) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (2010) (%) (2010) (2010) (%) (%)

Brassica Campestris Hydrogenated Rapeseed Vegetable (Olus) Oil Hydrogenated Vegetable Oil Canola Oil Canola Oil Unsaponifiables (Rapeseed) Seed Oil Oil Totals 165 0.0005-31 457 0.0004-60 27 0.007-17 1 0.3-4 132 0.0002-73 NR 0.001 Duration of Use Leave-On 135 0.0005-11 439 0.0005-60 23 0.007-17 NR 0.3-4 112 0.002-73 NR NR Rinse Off 30 0.002-31 18 0.0004-8 4 0.1-1 1 NR 20 0.02-33 NR 0.0001 Exposure Type Eye Area 11 0.01-11 102 0.008-49 2 NR NR 2 3 0.002-0.03 NR NR Possible Ingestion 74 0.03-11 216 0.8-60 1 9 NR NR 62 0.3-70 NR NR Inhalation 1 0.0005-0.02 1 3 NR NR NR NR 1 0.0002-17 NR NR Dermal Contact 143 0.0005-31 450 0.005-60 27 0.007-17 1 0.3-4 113 0.0002-73 NR NR Deodorant (Underarm) NR --- NR NR NR NR NR NR NR NR NR NR Hair - Non-Coloring 2 0.02-2 2 0.0005-0.09 NR 0.1 NR NR 19 0.006-24 NR 0.001 CIR Hair - Coloring 18 --- NR 0.0004-1 NR NR NR NR NR NR NR NR

NailPanel 1 2 1 0.2 NR NR NR NR NR 5 NR NR Mucous Membrane 1 0.03-2 2 2-4 1 NR NR NR 2 0.02-1 NR NR

BathBook Products 2 0.002-0.02 NR 0.5 NR NR NR NR 1 1-33 NR NR Baby Products 1 --- NR NR NR NR NR NR NR NR NR NR Page

39 Hydrogenated Canola Oil Palm Kernel Acid Elaeis Oleifera Kernel Oil Palm Acid Potassium Palmate Potassium Palm Kernelate Totals 3 NR 72 0.2-12 5 NR 33 1-17 5 0.3-3 7 0.3-30 Duration of Use Leave-On 2 NR 3 NR NR NR 1 NR NR NR NR NR Rinse-Off 1 NR 69 0.2-12 5 NR 32 1-17 5 0.3-3 7 0.3-30 Exposure Type Eye Area NR NR NR NR NR NR NR NR NR NR NR NR Possible Ingestion NR NR NR NR NR NR NR NR NR NR NR NR Inhalation NR NR NR NR NR NR 1 NR NR NR NR NR Dermal Contact 3 NR 71 0.2-12 NR NR 33 1-17 5 0.3-3 7 0.3-30 Deodorant (Underarm) NR NR NR NR NR NR NR NR NR NR NR NR Hair - Non-Coloring NR NR 1 NR 2 NR NR NR NR NR NR NR Hair - Coloring NR NR NR NR 3 NR NR NR NR NR NR NR Nail NR NR NR NR NR NR NR NR NR NR NR NR Mucous Membrane NR NR 64 0.2-3 NR NR 31 1-4 2 0.3-3 1 0.3-30 Bath Products NR NR NR NR NR NR NR NR NR NR NR NR Baby Products NR NR NR NR NR NR NR NR NR NR NR NR

Table 5a. Frequency of use according to duration and exposure. (continued) NR = Not reported to VCRP or Council. NS = Not yet surveyed. No. of Uses Conc. of Use No. of Uses Conc. of Use No. of Uses Conc. of Use No. of Uses Conc. of Use No. of Uses Conc. of Use No. of Uses Conc. of Use

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Glycine Soja (Soybean) Oil Helianthus Annuus Sodium Palmate Sodium Palm Kernelate Glycine Soja (Soybean) Oil Hydrogenated Soybean Oil Unsaponifiables (Sunflower) Seed Oil Totals 212 3-68 194 12-44 912 0.0002-95 12 0.0001-0.2 36 0.001-42 1414 0.000007-96 Duration of Use Leave-On 7 NR 10 NR 718 0.0005-95 12 0.0001-0.2 33 0.001-39 1054 0.0002-96 Rinse Off 205 3-68 184 12-44 194 0.0002-95 NR NR 3 0.05-42 360 0.000007-92 Exposure Type Eye Area NR NR NR NR 53 0.04-2 NR NR 4 0.03-7 64 0.0005-19 Possible Ingestion NR NR NR NR 103 0.6-4 NR NR 3 0.1-39 260 0.08-41 Inhalation 1 NR 1 NR 6 0.03-0.5 NR NR NR NR 3 0.0002-85 Dermal Contact 212 3-68 194 12-44 800 0.0005-93 12 0.0001-0.2 34 0.01-39 707 0.0002-96 Deodorant (Underarm) NR NR NR NR NR 0.01-0.5 NR NR NR NR 1 0.0003-4 Hair - Non-Coloring NR NR NR NR 97 0.0002-95 NR NR 1 0.1 179 0.000007-92

HairCIR - Coloring NR NR NR NR 5 NR NR NR NR NR 85 0.03-35 Nail NR NR NR NR 6 0.02-95 NR NR NR 0.001-25 8 0.05-30 Panel Mucous Membrane 189 3-68 173 16-44 70 0.01-52 NR NR NR 0.05-6 52 0.0003-4 Bath Products 1 NR 3 NR 19 0.1-78 NR NR NR 5-42 11 0.005-75 Book Baby Products 3 NR 4 NR 21 2 NR NR NR NR 18 0.2

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40 Hel. Annuus (Sunflower) Hydrogenated Sunflower Olea Europea (Olive) Fruit Hydrogenated Olive Oil Olea Europaea (Olive) Oil Hydrogenated Olive Oil Seed Oil Unsaponifiables Seed Oil Oil Unsaponifiables Unsaponifiables Totals 10 0.005-2 NR 6-35 915 0.0005-100 50 0.0005-12 2 0.05-5 77 0.0001-3 Duration of Use Leave-On 10 0.005-2 NR 6-35 617 0.001-100 36 0.1-12 2 0.05-5 68 0.0001-3 Rinse-Off NR 0.002 NR 15-35 298 0.0005-94 14 0.0005-0.1 NR NR 9 0.04-0.3 Exposure Type Eye Area 2 0.02 NR 7 26 0.004-17 13 0.1-3 NR 0.3-2 12 0.02-0.4 Possible Ingestion NR NR NR 6 26 0.7-26 7 0.1-12 NR NR 1 0.08 Inhalation NR NR NR NR 6 0.2-5 NR NR NR NR NR 3 Dermal Contact 10 0.005-2 NR 6-35 711 0.0005-100 34 0.0005-12 2 0.05-5 67 0.0001-3 Deodorant (Underarm) NR NR NR NR 3 0.02-0.1 NR NR NR NR NR NR Hair - Non-Coloring NR NR NR NR 190 0.006-94 11 0.01-0.1 NR NR 6 0.02-0.3 Hair - Coloring NR NR NR 15-35 NR 0.2-0.5 NR NR NR NR NR NR Nail NR NR NR NR 5 1-40 NR NR NR NR NR NR Mucous Membrane NR 0.002 NR NR 121 0.0005-3 1 0.0005 NR NR 4 NR Bath Products NR NR NR NR 14 0.9-17 NR NR NR NR NR NR Baby Products NR NR NR NR 9 0.2 NR 0.4 NR NR NR 0.04 31

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Actinidia Chinensis (Kiwi) Adansonia Digitata Oil Argania Spinosa Kernel Oil Astrocaryum Murumuru Potassium Olivate Sodium Olivate Seed Oil [Baobab] [Argan] Seed Butter [Murumura] Totals 3 NR 16 4-18 7 0.1 6 0.01 100 0.001-10 192 0.001-7 Duration of Use Leave-On NR NR 5 NR 5 NR 4 0.01 87 0.001-10 171 0.001-7 Rinse Off 3 NR 11 4-18 2 0.1 2 NR 13 0.001-2 21 0.001-0.2 Exposure Type Eye Area NR NR NR NR NR NR NR NR 11 0.1-1 21 0.06-0.5 Possible Ingestion NR NR NR NR 1 NR NR 0.01 9 0.1-1 22 1-7 Inhalation NR NR NR NR 1 NR NR NR NR 0.01 NR NR Dermal Contact 3 NR 16 4-18 5 NR 5 0.01 88 0.001-10 178 0.001-7 Deodorant (Underarm) NR NR NR NR NR NR NR NR NR 0.001 NR NR Hair - Non-Coloring NR NR NR NR 2 0.1 1 NR 8 0.01-1 11 0.001-0.2

HairCIR - Coloring NR NR NR NR NR NR NR NR NR 0.07-0.1 3 NR Nail NR NR NR NR NR NR NR NR 2 0.001-0..1 NR NR Panel Mucous Membrane 1 NR 9 4-18 NR NR NR NR 2 0.001-2 3 NR Bath Products NR NR NR NR NR NR NR NR 1 0.05 NR NR Book Baby Products NR NR 1 NR NR NR 1 NR NR NR NR NR

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41 Sodium Astrocaryum Avena Sativa (Oat) Kernel Borago Officinalis Seed Oil Brassica Oleracea Italica Camelina Sativa Seed Oil Camellia Japonica Seed Oil Murumuruate Oil [Borage] (Broccoli) Seed Oil [False Flax] Totals NR 0.002-0.005 43 0.01-3 180 0.001-1 NR 0.001-3 76 0.002-1 NR 0.01-0.2 Duration of Use Leave-On NR 0.002 37 0.1-3 160 0.001-1 NR 3 61 0.002-1 NR 0.01-0.2 Rinse-Off NR 0.002-0.005 6 0.001-0.1 20 0.001-0.01 NR 0.001-0.5 15 1 NR 0.1 Exposure Type Eye Area NR NR NR 0.2 7 0.001-0.5 NR NR NR 0.05 NR 0.01 Possible Ingestion NR NR NR 2 NR 0.01 NR NR 34 0.05-0.5 NR 0.1 Inhalation NR NR NR NR 3 0.1 NR NR NR NR NR NR Dermal Contact NR 0.002-0.005 41 0.001-3 168 0.001-1 NR NR 47 0.002-1 NR 0.01-0.2 Deodorant (Underarm) NR NR NR NR NR NR NR NR NR NR NR 0.01 Hair - Non-Coloring NR NR 2 0.1 10 NR NR NR 29 1 NR 0.1 Hair - Coloring NR NR NR NR NR NR NR 0.001-3 NR NR NR NR Nail NR NR NR NR NR NR NR NR NR NR NR NR Mucous Membrane NR 0.002 2 0.01-0.1 4 0.001-0.01 NR NR NR NR NR 0.1 Bath Products NR NR 1 NR 1 NR NR NR NR NR NR NR Baby Products NR NR 6 0.1 3 NR NR NR NR NR NR NR 32

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Camellia Oleifera Seed Oil Hydrogenated Camellia Caryocar Brasilense Fruit Chenopodium Quinoa Seed Camellia Sinensis Seed Oil Carica Papaya Seed Oil [Tea Seed] Oleifera Seed Oil Oil (Pequi) Oil [Quinoa] Totals 25 0.003-3 1 NR 12 0.1 NR 0.1 31 0.0005-0.2 1 0.3 Duration of Use Leave-On 23 0.003-3 1 NR 8 0.1 NR 0.1 29 0.0005-2 1 NR Rinse Off 2 0.01-0.1 NR NR 4 0.1 NR NR 2 NR NR 0.3 Exposure Type Eye Area NR 2 NR NR NR NR NR NR 12 NR NR NR Possible Ingestion 3 3 NR NR 1 0.1 NR NR 12 0.2 NR NR Inhalation NR NR NR NR NR NR NR NR NR NR NR NR Dermal Contact 23 0.003-3 1 NR 10 0.1 NR 0.1 30 0.0005-0.2 NR NR Deodorant (Underarm) NR NR NR NR NR 0.1 NR NR NR NR NR NR Hair - Non-Coloring 2 2 NR NR 2 0.1 NR NR 1 NR 1 NR

HairCIR - Coloring NR NR NR NR NR NR NR NR NR NR NR 0.3 Nail NR NR NR NR NR NR NR NR NR NR NR NR Panel Mucous Membrane NR 0.01-0.1 NR NR 2 0.1 NR NR NR NR NR NR Bath Products NR 0.05 NR NR NR NR NR NR NR NR NR NR Book Baby Products NR NR NR NR NR NR NR NR NR NR NR NR

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42 Citrullus Lanatus Citrus Vulgaris Citrus Grandis (Grapefruit) Citrus Paradisi (Grapefruit) Citrus Medica Limonum Cucumis Sativus (Cucumber) (Watermelon) Seed Oil (Watermelon) Seed Oil Seed Oil Seed Oil (Lemon) Seed Oil Seed Oil Totals 1 2 1 NR NR 0.1 6 NR 5 NR 6 NR Duration of Use Leave-On 1 2 1 NR NR 0.1 5 NR 3 NR 5 NR Rinse-Off NR NR NR NR NR 0.1 1 NR 2 NR 1 NR Exposure Type Eye Area NR NR NR NR NR NR NR NR NR NR 1 NR Possible Ingestion NR NR NR NR NR 0.1 NR NR NR NR NR NR Inhalation NR NR NR NR NR NR NR NR NR NR NR NR Dermal Contact 1 2 1 NR NR 0.1 6 NR 5 NR 5 NR Deodorant (Underarm) NR NR NR NR NR NR NR NR NR NR NR NR Hair - Non-Coloring NR NR NR NR NR 0.1 NR NR NR NR 1 NR Hair - Coloring NR NR NR NR NR NR NR NR NR NR NR NR Nail NR NR NR NR NR NR NR NR NR NR NR NR Mucous Membrane NR NR NR NR NR 0.1 1 NR 1 NR NR NR Bath Products NR NR NR NR NR NR NR NR NR NR NR NR Baby Products NR NR NR NR NR NR NR NR NR NR NR NR 33

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Cucurbita Pepo (Pumpkin) Euterpe Oleracea Fruit Oil Irvingia Gabonensis Kernel Limnanthes Alba Linum Usitatissimum Linseed Acid Seed Oil [Acai] Butter [Dika] (Meadowfoam) Seed Oil (Linseed) Seed Oil Totals 18 0.003-0.1 29 0.00001-0.5 109 0.003-0.4 316 0.002-74 102 0.001-10 3 NR Duration of Use Leave-On 17 0.003-0.1 19 0.00001-0.5 109 0.003-0.4 225 0.002-74 52 0.002-10 3 NR Rinse Off 1 NR 10 0.05 NR NR 91 0.01-2 50 0.001-0.4 NR NR Exposure Type Eye Area 1 0.003 2 0.5 2 NR 30 0.1-20 3 0.01 NR NR Possible Ingestion NR NR 1 0.002 64 0.003-0.3 67 0.6-26 NR 0.01 NR NR Inhalation 1 NR 1 NR NR NR 1 0.1-3 3 NR NR NR Dermal Contact 18 0.003-0.1 14 0.00001-0.5 108 0.003-0.4 211 0.002-74 58 0.003-4 3 NR Deodorant (Underarm) NR NR NR NR NR NR NR NR NR 0.05-0.1 NR NR Hair - Non-Coloring 1 NR 15 NR 1 NR 47 0.1-1 42 0.001-0.1 NR NR

HairCIR - Coloring NR NR NR NR NR NR 46 0.2-2 NR NR NR NR Nail NR NR NR NR NR NR NR 0.5 2 0.002-0.05 NR NR MucousPanel Membrane NR NR 3 NR NR NR 4 0.001-0.6 5 0.003-0.4 NR NR Bath Products NR NR NR NR NR NR 2 0.5-0.9 1 0.02-0.2 NR NR BabyBook Products NR NR NR NR NR NR 1 NR 2 NR 1 NR

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43 Mangifera Indica (Mango) Mangifera Indica (Mango) Moringa Oleifera Seed Oil Moringa Pterygosperma Oenothera Biennis (Evening Sodium Mangoseedate Seed Oil Seed Butter [Ben] Seed Oil Primrose) Oil Totals 72 0.003-6 175 0.0005-3 1 NR NR 0.001 15 0.003-3 150 0.00002-58 Duration of Use Leave-On 64 0.003-6 134 0.01-5 NR NR NR 0.001 13 0.004-3 113 0.00002-58 Rinse-Off 8 0.05-0.2 41 0.0005-0.5 1 NR NR NR 2 0.003 37 0.002-0.2 Exposure Type Eye Area 13 5 6 0.02 NR NR NR NR 4 3 4 0.00002-0.5 Possible Ingestion 7 0.03-6 25 1-5 NR NR NR NR 1 NR 14 0.1-15 Inhalation 1 NR 2 0.02 NR NR NR NR NR NR 2 NR Dermal Contact 60 0.003-6 147 0.0005-5 1 NR NR 0.001 11 0.003-3 109 0.00002-58 Deodorant (Underarm) NR NR NR NR NR NR NR NR NR NR NR 0.2 Hair - Non-Coloring 12 0.05-0.2 12 0.02-0.5 NR NR NR NR 1 0.02 37 0.05-0.1 Hair - Coloring NR 0.05 16 NR NR NR NR NR NR NR NR NR Nail NR NR NR 0.5 NR NR NR NR NR NR 4 0.001-3 Mucous Membrane 2 0.1 10 0.0005-0.5 1 NR NR NR NR 0.003 4 0.1-0.2 Bath Products NR NR 1 NR NR NR NR NR NR NR 2 0.2 Baby Products NR NR 3 NR NR NR NR NR NR NR 3 NR 34

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Hydrogenated Evening Orbignya Oleifera Seed Oil Perilla Ocymoides Seed Oil Orgibnya Cohume Seed Oil Sodium Babassuate Hydrogenated Avocado Oil Primrose Oil [Babassu] [Perilla] Totals 14 NR 1 NR 161 0.0009-27 NR 8 7 NR 11 0.5 Duration of Use Leave-On 14 NR NR NR 118 0.0009-4 NR NR 5 NR 9 NR Rinse Off NR NR 1 NR 43 0.01-27 NR 8 2 NR 2 0.5 Exposure Type Eye Area 1 NR NR NR 7 0.5-0.6 NR NR 2 NR NR NR Possible Ingestion NR NR NR NR 57 0.001-2 NR NR NR NR 2 NR Inhalation NR NR NR NR 5 0.02-2 NR NR NR NR NR NR Dermal Contact 14 NR NR NR 110 0.0009-27 NR 8 5 NR 8 NR Deodorant (Underarm) NR NR NR NR NR NR NR NR NR NR NR NR Hair - Non-Coloring NR NR 1 NR 43 0.02-2 NR NR 2 NR 3 0.5

HairCIR - Coloring NR NR NR NR 8 NR NR NR NR NR NR NR Nail NR NR NR NR NR NR NR NR NR NR NR NR Panel Mucous Membrane NR NR NR NR 5 27 NR 8 NR NR NR NR Bath Products NR NR NR NR 2 0.01-0.1 NR NR NR NR NR NR Book Baby Products NR NR NR NR NR NR NR NR NR NR NR NR

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44 Persea Gratissima (Avocado) Persea Gratissima (Avocado) Plukenetia Volubilis Seed Oil Prunus Armeniaca (Apricot) Hydrogenated Apricot Sodium Avocadoate Butter Oil Unsapon. [Sacha Inchi] Kernel Oil Kernel Oil Totals 15 NR 63 0.2-6 1 NR 13 NS 588 0.00001-89 2 NR Duration of Use Leave-On 15 NR 57 0.5-6 NR NR 12 NS 449 0.0001-40 2 NR Rinse-Off NR NR 6 0.2 1 NR 1 NS 139 0.00001-89 NR NR Exposure Type Eye Area NR NR 9 0.5 NR NR 1 NS 25 0.002-18 NR NR Possible Ingestion 11 NR 2 3 NR NR 3 NS 38 0.001-5 NR NR Inhalation NR NR 4 NR NR NR NR NS 5 0.0009-1 NR NR Dermal Contact 15 NR 56 0.2-3 1 NR 13 NS 486 0.00001-18 2 NR Deodorant (Underarm) NR NR NR NR NR NR NR NS 1 0.003-0.1 NR NR Hair - Non-Coloring NR NR 2 6 NR NR NR NS 78 0.0001-89 NR NR Hair - Coloring NR NR NR NR NR NR NR NS 10 0.1 NR NR Nail NR NR 3 NR NR NR NR NS 10 0.002-40 NR NR Mucous Membrane NR NR NR NR 1 NR NR NS 24 0.01-9 NR NR Bath Products NR NR 4 NR NR NR NR NS 8 4 NR NR Baby Products NR NR 1 NR NR NR NR NS 7 NR NR NR 35

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Prunus Avium (Sweet Prunus Domestica Seed Oil Prunus Persica (Peach) Pyrus Malus (Apple) Seed Ribes Nigrum (Black Rubus Idaeus (Raspberry) Cherry) Seed Oil [Prune/Plum] Kernel Oil Oil Currant) Seed Oil Seed Oil Totals 2 0.01-0.02 NR 0.04 22 0.003-22 8 NR 53 0.000001-0.3 10 0.1-5 Duration of Use Leave-On NR NR NR NR 16 0.05-22 8 NR 45 0.000001-0.3 8 0.1-5 Rinse Off 2 0.01-+0.02 NR 0.04 6 0.003-6 NR NR 8 0.05 2 NR Exposure Type Eye Area NR NR NR NR NR NR NR NR 2 0.08 NR NR Possible Ingestion NR NR NR NR NR 0.04-22 1 NR 7 0.03-0.1 1 NR Inhalation NR NR NR NR NR 2 NR NR NR NR NR NR Dermal Contact 2 0.01-0.02 NR 0.04 18 0.003-22 8 NR 43 0.000001-0.3 8 0.1-5 Deodorant (Underarm) NR NR NR NR NR NR NR NR NR NR NR NR Hair - Non-Coloring NR NR NR NR 4 NR NR NR 5 NR NR NR

HairCIR - Coloring NR NR NR NR NR 0.1 NR NR NR NR NR NR Nail NR NR NR NR NR NR NR NR 5 0.2 NR NR Panel Mucous Membrane 2 0.01-0.02 NR NR 1 NR NR NR 2 NR 2 NR Bath Products NR NR NR NR 1 0.1-1 NR NR NR NR 1 NR Book Baby Products NR NR NR NR NR NR NR NR NR NR NR NR

Page

45 Sclerocarya Birrea Seed Oil Silybum Marianum Seed Oil Solanum Lycopersicum Solanum Lycopersicum Theobroma Cacao (Cocoa) Theobroma Grandiflorum [Marula] [Thistle] (Tomato) Seed Oil (Tomato) Fruit Oil Seed Butter Seed Butter [Capuacu] Totals 29 1 NR 0.5 1 NR NR 0.01-1 442 0.000002-37 153 0.00005-7 Duration of Use Leave-On 23 1 NR 0.5 1 NR NR 0.001-1 367 0.000002-37 119 0.00005-7 Rinse-Off 6 1 NR NR NR NR NR NR 75 0.0001-2 34 0.001-1 Exposure Type Eye Area NR NR NR NR NR NR NR 0.01 11 0.0002-9 21 0.1-2 Possible Ingestion 6 NR NR NR NR NR NR 0.001 33 37 49 7 Inhalation 2 NR NR NR NR NR NR NR 2 0.4 NR NR Dermal Contact 23 1 NR 0.5 1 NR NR 0.001-1 417 0.000002-37 141 0.00005-7 Deodorant (Underarm) NR NR NR NR NR NR NR NR NR 0.001-1 NR 0.1 Hair - Non-Coloring 6 1 NR NR NR NR NR NR 24 0.01-2 9 0.001-1 Hair - Coloring NR NR NR NR NR NR NR NR NR 0.1 3 NR Nail NR NR NR NR NR NR NR NR NR 0.1-1 NR NR Mucous Membrane 2 NR NR NR NR NR NR NR 35 0.02-2 19 0.05-0.1 Bath Products NR NR NR NR NR NR NR NR 4 0.1-1 4 NR Baby Products NR NR NR NR NR NR NR NR 8 0.01 NR NR 36

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Triticum Vulgare (Wheat) Vaccinium Macrocarpon Vaccinium Oxycoccos Vitis Vinifera (Grape) Seed Wheat Germ Acid Sodium Grapeseedate Germ Oil Unsaponifiables (Cranberry) Seed Oil (Cranberry) Seed Oil Oil Totals 17 0.2 16 NR 21 0.002-2 4 NS 465 0.001-43 4 NR Duration of Use Leave-On 17 0.2 3 NR 18 0.002-2 3 NS 368 0.001-41 4 NR Rinse Off NR NR 13 NR 3 0.003-0.1 1 NS 97 0.001-43 NR NR Exposure Type Eye Area 1 NR NR NR 2 NR NR NS 14 0.01-5 NR NR Possible Ingestion NR NR NR NR NR 0.3 NR NS 34 0.03-7 NR NR Inhalation NR NR NR NR NR NR NR NS 6 0.001-7 NR NR Dermal Contact 17 0.2 NR NR 17 0.002-2 4 NS 401 0.001-41 NR NR Deodorant (Underarm) NR NR NR NR NR NR NR NS NR 0.001-0.2 NR NR Hair - Non-Coloring NR NR 16 NR 4 0.01-0.1 NR NS 46 0.01-0.3 4 NR

CIR Hair - Coloring NR NR NR NR NR NR NR NS 10 43 NR NR Nail NR NR NR NR NR NR NR NS 8 0.001-35 NR NR Panel Mucous Membrane NR NR NR NR 1 0.003-0.1 NR NS 21 0.001-7 NR NR Bath Products NR NR NR NR NR NR NR NS 8 0.01-2 NR NR Book Baby Products NR NR NR NR NR NR NR NS 5 NR NR NR

Page

46 Hippophae Rhamnoides Hydrogenated Grapeseed Oil Bassia Latifolia Seed Butter Camellia Kissi Seed Oil Crambe Abyssinica Seed Oil Garcinia Indica Seed Butter Fruit Oil Totals 7 0.3-0.5 22 NS 47 NS 26 NS 30 NS 7 NS Duration of Use Leave-On 4 0.3-0.5 17 NS 34 NS 15 NS 27 NS 7 NS Rinse Off 3 0.5 5 NS 13 NS 11 NS 3 NS NR NS Exposure Type Eye Area NR NR 4 NS 4 NS 1 NS 1 NS 1 NS Possible Ingestion 1 0.5 NR NS 1 NS 1 NS 3 NS NR NS Inhalation NR NR NR NS NR NS NR NS NR NS NR NS Dermal Contact 5 0.5 22 NS 36 NS 8 NS 30 NS 6 NS Deodorant (Underarm) NR NR NR NS NR NS NR NS NR NS NR NS Hair - Non-Coloring 1 NR NR NS 11 NS 14 NS NR NS NR NS Hair - Coloring NR NR NR NS NR NS 4 NS NR NS NR NS Nail 1 0.3 NR NS NR NS NR NS NR NS 1 NS Mucous Membrane 1 NR 5 NS 1 NS NR NS 1 NS NR NS Bath Products NR NR NR NS 1 NS NR NS NR NS NR NS Baby Products NR NR NR NS NR NS NR NS NR NS NR NS 37

(2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%) (2010) (2010) (%)

Orbignya Speciosa Kernel Hippophae Rhamnoides Oil Luffa Cylindrica Seed Oil Lupinus Albus Seed Oil Lycium Barbarum Seed Oil Passiflora Edulis Seed Oil Oil Totals 15 NS 21 NS 1 NS 2 NS 8 NS 62 NS Duration of Use Leave-On 10 NS 21 NS 1 NS 2 NS 1 NS 53 NS Rinse Off 5 NS NR NS NR NS NR NS 7 NS 9 NS Exposure Type Eye Area NR NS 1 NS NR NS 1 NS NR NS 3 NS Possible Ingestion NR NS 9 NS NR NS 1 NS NR NS 14 NS Inhalation NR NS NR NS NR NS NR NS NR NS 3 NS Dermal Contact 1 NS 21 NS 1 NS 2 NS NR NS 49 NS Deodorant (Underarm) NR NS NR NS NR NS NR NS NR NS NR NS Hair - Non-Coloring 6 NS NR NS NR NS NR NS 5 NS 10 NS

CIR Hair - Coloring NR NS NR NS NR NS NR NS 3 NS 3 NS Nail 8 NS NR NS NR NS NR NS NR NS NR NS Panel Mucous Membrane 1 NS NR NS NR NS NR NS NR NS 1 NS Bath Products NR NS NR NS NR NS NR NS NR NS NR NS Book Baby Products NR NS NR NS NR NS NR NS NR NS NR NS

Page

47 Vaccinium Myrtillus Seed Vaccinium Vitis-Idaea Seed Punica Granatum Seed Oil Rosa Canina Fruit Oil Rubus Chamemorus Seed Oil Vanilla Planifolia Fruit Oil Oil Oil Totals 46 NS 121 NS 3 NS 33 NS 9 NS 9 NS Duration of Use Leave-On 44 NS 106 NS 3 NS 32 NS 9 NS 8 NS Rinse Off 2 NS 15 NS NR NS 1 NS NR NS 1 NS Exposure Type Eye Area 2 NS 17 NS NR NS NR NS NR NS 2 NS Possible Ingestion 30 NS 7 NS NR NS 29 NS NR NS NR NS Inhalation NR NS 1 NS NR NS NR NS NR NS NR NS Dermal Contact 46 NS 109 NS 3 NS 33 NS 1 NS 9 NS Deodorant (Underarm) NR NS NR NS NR NS NR NS NR NS NR NS Hair - Non-Coloring NR NS 9 NS NR NS NR NS NR NS NR NS Hair - Coloring NR NS NR NS NR NS NR NS NR NS NR NS Nail NR NS 1 NS NR NS NR NS 8 NS NR NS Mucous Membrane 2 NS 3 NS NR NS NR NS NR NS 1 NS Bath Products NR NS 1 NS NR NS NR NS NR NS NR NS Baby Products NR NS NR NS NR NS NR NS NR NS NR NS 38

Table 5b. Current amd historical frequency and concentration of use according to duration and type of exposure - previously reviewed ingredients # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) Carthamus Tinctorius (Safflower) Seed Oil Elaeis Guineensis (Palm) Oil Elaeis Guineensis (Palm) Kernel Oil Hydrogenated Palm Oil data year 2002 2010 2003 2010 1997 2010 1997 2010 1997 2010 1997 2010 1997 2010 1997 2010 142 508 0.00005- NS 36 272 ** 0.002-48 11 77 ** 0.05-23 13 0.2-30 Totals 152 84 ** Duration of Use 114 402 0.00005- NS 28 171 ** 0.008-13 9 60 ** 0.8-3 13 0.2-30 Leave-On 84 134 ** Rinse Off 28 106 0.001-72 NS 8 101 ** 0.002-48 2 17 ** 0.05-23 NR 18 ** 2 Exposure Type Eye Area 5 15 1-6 NS NR 12 ** 0.04-2 NR 10 ** 0.8 1 61 ** 0.2-30 Possible Ingestion 18 83 0.1-60 NS NR 11 ** 2 NR 6 ** NR 3 12 ** 2-30 Inhalation 3 5 5 NS 1 3 ** NR NR NR ** NR NR NR ** 1 Dermal Contact 113 395 0.001-72 NS 36 229 ** 0.002-48 11 71 ** 0.05-2 12 123 ** 0.4-30 Deodorant (underarm) NR NR NR NS NR NR ** NR NR NR ** NR NR NR ** NR 28 79 0.00005- NS NR 43 ** 2-34 NR 6 ** 0.9-23 NR NR ** NR Hair - Non-Coloring 27 Hair-Coloring NR 20 1 NS NR NR ** NR NR NR ** NR NR NR ** NR

CIR Nail 1 32 84 NS NR NR ** NR NR NR ** 3 NR NR ** NR Mucous Membrane NR 31 NR NS 7 68 ** 0.002-48 NR 10 ** 0.05 NR 17 ** 2 Panel Bath Products NR 3 7 NS NR NR ** NR NR 1 ** NR NR NR ** NR Baby Products NR 6 10 NS 1 2 ** NR NR NR ** NR NR NR ** NR Book

Page Hydrogenated Palm Kernel Oil Gossypium Herbaceum (Cotton) Seed Oil Hydrogenated Cottonseed Oil Oryza Sativa (Rice) Bran Oil data year 1997 2010 1997 2010 1998 2010 1998 2010 1998 2010 1998 2010 2002 2010 2000- 2010

48 2003 Totals 29 47 ** 0.4-13 4 83 0.004-32 272 362 ** 0.001-24 39 371 0.1-39 0.0003-78 Duration of Use ** Leave-On 27 45 ** 0.4-13 1 68 0.08-32 272 358 ** 0.001-24 32 267 0.1-8 0.0003-78 Rinse-Off 2 2 ** 0.6-2 3 15 ** 0.004-29 NR 4 ** 0.01-0.1 7 104 0.2-39 0.005-6 Exposure Type ** Eye Area 5 2 ** 2-10 NR 4 0.1-11 116 155 ** 0.5-24 NR 5 0.1-1 0.5-0.8 Possible Ingestion 2 5 ** 3-13 NR 9 ** 0.2-1 151 NR ** 8-12 NR 17 0.1-1 0.1-8 Inhalation NR 1 ** NR NR 12 ** 0.2 NR NR ** NR NR 11 NR 0.1 Dermal Contact 24 47 ** 0.4-13 4 78 ** 0.004-29 156 356 ** 0.001-24 36 321 0.1-39 0.0003-27 Deodorant (underarm) NR NR ** NR NR 1 ** 0.2 NR NR ** NR NR NR NR 0.5 Hair - Non-Coloring NR NR ** NR NR 2 ** NR NR 4 ** 0.01-0.1 3 33 0.3 0.005-0.5 Hair-Coloring NR NR ** NR NR NR ** NR NR NR ** NR NR NR NR 0.3 Nail NR NR ** NR NR 1 ** 0.5-32 NR NR ** NR 2 5 NR 0.02-78 2 2 ** 0.9-2 NR 7 ** 0.004- NR NR ** NR 48 0.0006-6 Mucous Membrane NR 1 0.01 Bath Products NR NR ** NR NR NR ** NR NR NR ** NR 1 17 ,1-39 0.2 Baby Products NR NR ** NR NR NR ** NR NR 8 ** NR NR 1 NR NR NR - not reported to the VCRP or the Council ** concentration of use data were not given in the original report

Table 5b. Current amd historical frequency and concentration of use* according to duration and type of exposure - previously reviewed ingredients (continued) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) Sesamum Indicum (Sesame) Oil Oryza Sativa (Rice) Germ Oil Sesamum Indicum (Sesame) Seed Oil Zea Mays (Corn) Oil Unsaponifiables data year 2000- 2002 2010 2010 1987 2010 1987 2010 1987 2010 1987 2010 2007 2010 2006 2010 2003 6 34 0.1 0.003-3 253 480 ≤1 - >50 NS NR 17 NR NS 498 0.00003- NS Totals 598 14 Duration of Use 5 29 0.1 0.003-3 35 374 ≤1 - >50 NS NR 17 NR NS 241 0.00003- NS Leave-On 361 14 1 5 NR 0.003-3 218 106 ≤1 - >50 NS NR NR NR NS 257 0.001- NS Rinse Off 237 0.07 Exposure Type NR 2 NR 0.01-1 6 14 ≤1 - >50 NS NR NR NR NS 39 35 0.0008- NS Eye Area 0.2 Possible Ingestion NR 4 NR 0.1-3 59 52 ≤1 - 10 NS NR 11 NR NS 29 30 0.003-10 NS Inhalation NR NR NR NR NR 5 NR NS NR NR NR NS 1 1 0.001-0.1 NS 6 32 0.1 0.003-3 233 414 NS NR 17 NR NS 276 371 0.00003- NS Dermal Contact ≤1-50 14 Deodorant (underarm) NR NR NR 0.003 NR NR NR NS NR NR NR NS 1 4 NR NS CIR NR NR NR NR 11 59 NS NR NR NR NS 38 40 0.0001- NS Hair - Non-Coloring ≤1-50 0.02 Panel NR NR NR NR NR NR NR NS NR NR NR NS 182 183 0.004- NS Hair-Coloring 0.007

Book Nail NR NR NR NR 3 7 ≤1-10 NS NR NR NR NS 1 3 0.001-5 NS NR 1 NR 0.003- NR 28 NR NS NR NR NR NS 2 2 0.004- NS Mucous Membrane Page 0.005 0.01 NR 1 NR 0.5 3 5 1-50 NS NR NR NR NS NR NR 0.001- NS Bath Products

49 0.01 Baby Products NR NR NR NR 2 3 1-50 NS NR NR NR NS 8 8 0.004 NS NR - not reported to the VCRP or the Council ** concentration of use data were not given in the original report

Table 5b. Current amd historical frequency and concentration of use* according to duration and type of exposure - previously reviewed ingredients (continued) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) # of Uses Conc. of Use (%) Zea Mays (Corn) Germ Oil Zea Mays (Corn) Oil Unsaponifiables Persea Gratissima (Avocado) Oil Triticum Vulgare (Wheat) Germ Oil data year 2007 2010 2006 2010 2007 2010 2006 2010 2001 2010 2001 2010 2001 2010 2001 2010 37 53 NS 7 NS 188 303 527 0.00002- 0.0001-28 Totals 0.2-25 1 NR 883 0.001-23 0.0001-98 18 Duration of Use 25 34 NS 6 NS 40 80 373 0.00002- 0.0001-28 Leave-On 0.0005-98 3-25 1 NR 657 0.001-23 18 Rinse-Off 12 19 0.2-3 NS 1 NR NR NS 148 226 0.1-5 0.0001-15 223 154 0.00002-5 0.001-2 Exposure Type Eye Area NR NR NR NS NR NR NR NS 8 24 0.1-3 0.05-2 9 12 0.00004-3 0.0001-0.5 Possible Ingestion NR NR NR NS NR NR NR NS 29 60 0.7-21 0.05-26 33 29 0.1-3 0.3-5 NR NR NR NS NR NR NR NS 2 11 0.02-3 0.01-8 2 7 0.0002- 0.0001-0.0005 Inhalation 0.01 31 50 3-25 NS 7 1 NR NS 165 685 0.001-23 0.0005--98 220 360 0.00002- 0.0005-23 Dermal Contact 18 Deodorant (underarm) NR NR NR NS NR NR NR NS NR NR NR 0.1 NR NR 0.02 NR Hair - Non-Coloring 4 3 0.2 NS NR NR NR NS 11 189 0.002-3 0.0001-41 63 142 0.0001-2 0.0001-<1 Hair-ColoringCIR NR NR NR NS NR NR NR NS 8 NR NR 0.3 12 20 0.1 0.01-0.2

NailPanel NR NR NR NS NR NR NR NS 4 7 0.4-19 0.001-34 4 2 0.1-4 0.1-28 Mucous Membrane 4 3 3 NS NR NR NR NS NR 43 0.1-5 0.002-3 3 22 0.02-1 0.01-0.5

BathBook Products 3 4 NR NS NR NR NR NS 5 25 0.1-5 0.6-6 1 2 0.001-2 0.5 Baby Products 2 4 NR NS NR NR NR NS NR 9 NR NR 1 9 0.5 NR NRPage - not reported to the VCRP or the Council ** concentration of use data were not given in the original report 50

Table 5c. Ingredients not reported to be used

Brassica Campestris (Rapeseed) Oil Unsaponifiables Hydrogenated Grapefruit Seed Oil Unsaponifiables Potasium Rapeseedate Citrus Limon (Lemon) Seed Oil Rapeseed Acid Coix Lacryma-Jobi (Job's Tears) Seed Oil Sodium Rapeseedate Hydrogenated Pumpkin Seed Oil Hydroganted Safflower Seed Oil Cynara Cardunculus Seed Oil [Artichoke] Potassium Safflowerate Fragaria Ananassa (Strawberry) Seed Oil Safflower Acid Fragaria Chiloensis (Strawberry) Seed Oil Sodium Safflowerate Fragaria Vesca (Strawberry) Seed Oil Elaeis Guineensis (Palm) Butter Fragaria Virginiana (Strawberry) Seed Oil Hydrogenated Palm Acid Guizotia Abyssinica Seed Oil [Ramtil] Potassium Hydrogenated Palmate Hydrogenated Meadowfoam Seed Oil Sodium Hydrogenated Palmate Babassu Acid Soy Acid Potassium Babassuate Potassium Soyate Hydrogenated Apricot Kernel Oil Sodium Soyate Hydrogenated Apricot Kernel Oil Unsaponifiables Cottonseed Acid Prunus Armeniaca (Apricot) Kernel Oil Unsaponifiables Sunflower Seed Acid Hydrogenated Peach Kernel Oil Olive Acid Hydrogenated Black Currant Seed Oil Rice Bran Acid Ribes Rubrum (Currant) Seed Oil Hydrogenated Rice Bran Oil Hydrogenated Raspberry Seed Oil Oryza Sativa (Rice) Seed Oil Sodium Cocoa Butterate Hydrogenated Sesame Seed Oil Sodium Theobroma Grandiflorum Seedate Sodium Sesameseedate Torreya Nucifera Seed Oil [Kaya] Sesamum Indicum (Sesame) Seed Butter Hydrogenated Wheat Germ Oil Corn Acid Hydrogenated Wheat Germ Oil Unsaponifiables Potassium Cornate Triticum Aestivum (Wheat) Germ Oil Adansonia Digitata Seed Oil Hydrogenated Cranberry Seed Oil Hydrogenated Adansonia Digitata Seed Oil Vitis Vinifera (Grape) Seed Oil Amaranthus Hypochondriacus Seed Oil Sodium Grapeseedate Arctium Lappa Seed Oil Hydrogenated Grapeseed Oil Hydrogenated Argania Spinosa Kernel Oil Bassia Butyracea Seed Butter Hydrogenated Camelina Sativa Seed Oil Brassica Napus Seed Oil [Rapeseed] Citrus Aurantifolia (Lime) Seed Oil Brassica Oleracea Acephala Seed Oil [Kale] Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables Hippophae Rhamnoides Seed Oil [Sea-Buckthorn] Hydrogenated Lime Seed Oil Lupinus Albus Oil Unsaponifiables Hydrogenated Lime Seed Oil Unsaponifiables Morinda Citrifolia Seed Oil [Noni] Citrus Aurantium Dulcis (Orange) Seed Oil Hydrogenated Passiflora Edulis Seed Oil Citrus Aurantium Dulcis (Orange) Seed Oil Unsaponifiables Hydrogenated Punica Granatum Seed Oil Hydrogenated Orange Seed Oil Hydrogenated Rosa Canina Fruit Oil Hydrogenated Orange Seed Oil Unsaponifiables Rubus Chamaemorus Seed Oil [Cloudberry] Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables Vaccinium Corymbosum (Blueberry) Seed Oil Hydrogenated Grapefruit Seed Oil Vanilla Planifolia Fruit Oil [Vanilla]

CIR Panel Book Page 51

5d. Ingredients for which concentration of use information has not yet been provided

Carthamus Tinctorius Safflower Seed Oil Garcinia Indica Seed Butter [Kokum] Oryza Sativea (Rice) Germ Oil Hippophae Rhamnoides Fruit Oil [Sea-Buckthorn] Sesamum Indicum (Sesame) Seed Oil Hippophae Rhamnoides Oil [Sea-Buckthorn] Hydrogenated Sesame Seed Oil Hippophae Rhamnoides Seed Oil [Sea-Buckthorn] Sesamum Indicum (Sesame) Oil Unsaponifiables Luffa Cylindrica Seed Oil [Luffa] Sodium Sesameseedate Lupinus Albus Seed Oil [White Lupine] Zea Mays (Corn) Oil Lupinus Albus Oil Unsaponifiables Zea Mays (Corn) Germ Oil Lycium Barbarum Seed Oil [Goji Berry] Zea Mays (Corn) Oil Unsaponifiables Morinda Citrifolia Seed Oil [Noni] Corn Acid Orbignya Speciosa Kernel Oil [Babassu] Potassium Cornate Passiflora Edulis Seed Oil [Passion Fruit] Orgibnuya Cohune Seed Oil [Cohune] Hydrogenated Passiflora Edulis Seed Oil Plukenetia Volubilis Seed Oil [Sacha Inchi] Punica Granatum Seed Oil [Pomegrante] Triticum Vulgare (Wheat) Germ Oil Unsaponifiables Hydrogenated Punica Granatum Seed Oil Bassia Butyracea Seed Butter Rosa Canina Fruit Oil [Dog Rose] Bassia Latifolia Seed Butter [Mahwa] Hydrogenated Rosa Canina Fruit Oil Brassica Napus Seed Oil [Rapeseed] Rubus Chamaemorus Seed Oil [Cloudberry] Brassica Oleracea Acephala Seed Oil [Kale] Vaccinium Corymbosum (Blueberry) Seed Oil Camellia Kissi Seed Oil [Tea] Vaccinium Myrtillus Seed Oil [Bilberry] Crambe Abyssinica Seed Oil [Abyssinian Mustard] Vaccinium Vitis-Idaea Seed Oil [Ligonberry] Vanilla Planifolia Fruit Oil [Vanilla]

CIR Panel Book Page 52

Table 6. Non-food, non-cosmetic uses of edible oils.3

Oil Use rapeseed/canola rubber additive lubricants fat liquoring of leather varnishes and lacquers textile chemicals detergent additives plasticizers weed control medicinal procedures sunflower manufacturing of lacquers, copolymers, polyester films, modified resins, plasticizers, alkyld resins, other similar products palm crayon and candle manufacturing tin plate industry palm kernel detergent production pharmaceutical crayon and candle manufacturing tin plate industry niger paint lubricant pharmaceutical olive textile industry pharmaceutical cocoa pharmaceutical grapeseed substitute for linseed oil in the manufacture of paints, and varnishes perilla substitute for linseed oil in the manufacture of paints, varnishes, linoleum, oilclothes, and printing inks false flax drying oil manufacturing of varnishes and paints

CIR watermelon illumination apricot pharmaceutical Panel cohune manufacturing of soaps, candles, and nightlights cotton dyeing ointment base substitute for cocoa butter in food Book linseed manufacturing of linoleum, cloth oil, printing and lithographic inks, core oils, linings, packings, oil-modified alkyd resins, caulking compounds, putties, leather-finishing compounds, lubricants, greases, polishes, Page pyrotechnic compositions pigment binder in petrochemicals concrete protector stabilizer/plasticizer for vinyl plastics industrial stains jute textiles drying oil in paints and varnishes 53

Table 7. Clinical irritation and sensitization studies on vegetable oils. Ingredient and Concentration Subjects Completed Method Results Reference 0.01% Adansonia Digitata Seed Oil [Baobab] in a lip product 106 HRIPT with 0.2 g test material, semi-occluded not a dermal irritation or sensitizer 116 HRIPT with 0.02-0.05 ml test material, semi- 100% Adansonia Digitata Seed Oil [Baobab] 107 occluded not a dermal irritant or sensitizer 117 1% Astrocaryum Murumuru Seed Butter [Murumuru] in a lipstick 97 HRIPT with 150 mg test material, semi-occluded not a dermal irritation or sensitizer 118

4% Astrocaryum Murumuru Seed Butter in a lipstick 108 HRIPT, occluded not a dermal irritant or sensitizer 119

4% Astrocaryum Murumuru Seed Butter in a lipstick 108 HRIPT, occluded not a dermal irritant or sensitizer 120

4% Astrocaryum Murumuru Seed Butter in a lipstick 108 HRIPT, occluded not a dermal irritant or sensitizer 121

4% Astrocaryum Murumuru Seed Butter in a lipstick 106 HRIPT, occluded not a dermal irritant or sensitizer 122

4% Astrocaryum Murumuru Seed Butter in a lipstick 106 HRIPT, occluded not a dermal irritant or sensitizer 123 CIR 4% Astrocaryum Murumuru Seed Butter in a lipstick 108 HRIPT, occluded not a dermal irritant or sensitizer 124 Panel 3% Avena Sativa (Oat)Kernel Oil in a body and hand formulation 100 HRIPT with 0.2 ml, occluded not a dermal irritant or sensitizer 125 Book 1% Borago Officinalis Seed Oil in a body and hand formulation 213 HRIPT with 0.2 g, occluded not a dermal irritant or sensitizer 126 Page

5% Hydrogenated Rapeseed Oil in a baby oil 105 HRIPT with 0.2 ml, semi-occluded not a dermal irritant or sensitizer 127 54

0.5% Brassica Oleracea Italica (Broccoli) Seed Oil in a HRIPT with 150 µl of test material, 10% dilution, hair conditioner 102 semi-occluded not a dermal irritation or sensitizer 128

0.0985% Camellia Sinensis Seed Oil in a lipstick 108 HRIPT with 0.2 g, occluded not a dermal irritant or sensitizer 129

0.0985% Camellia Sinensis Seed Oil in a lipstick 108 HRIPT with 0.2 g, occluded not a dermal irritant or sensitizer 130

74.7% Canola Oil in a body oil 101 HRIPT with 150 µl test material, semi-occluded not a dermal irritant or sensitizer 131

0.1% Caryocar Brailinese Fruit Oil in a lipstick 100 HRIPT with 200 mg test material, semi-occluded not a dermal irritant or sensitizer 132 2% Citrullus Lanatus (Watermelon) Seed Oil in a facial oil 105 HRIPT, semi-occluded not a dermal irritant or sensitizer 133

0.5% Euterpe Oleracea Fruit Oil in an eye treatment 104 HRIPT with 150 µl test material, semi-occluded not a dermal irritant or sensitizer 134

0.19% Glycine Soja (Soybean) Unsaponifiables in a face and neck product 50 HRIPT, occluded not a dermal irritation or sensitizer 135

Table 7. Clinical irritation and sensitization studies on vegetable oils. Ingredient and Concentration Subjects Completed Method Results Reference

39% Hydrogenated Soybean Oil in a lipstick 108 HRIPT, occluded not a dermal irritant or sensitizer 136

2% Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables in a night product 100 HRIPT, semi-occluded not a dermal irritation or sensitizer 135

2% Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables in a face and neck product 100 HRIPT, semi-occluded not a dermal irritation or sensitizer 135

0.31% Irvingia Ganensis Kernel Butter [Dika] in a face and neck product 52 HRIPT, occluded not a dermal irritation or sensitizer 135

7 subjects had + on the first day of the 71.3% Limnanthes Alba (Meadowfoam) Seed Oil in a induction only, no other reactions. Not facial repair product 109 HRIPT, semi-occluded a dermal irritant or sensitizer. 137 9.4% Linum Usitatissimum (Linseed) Seed Oil in mascara 105 HRIPT with 0.2 g test material, semi-occluded not a dermal irritation or sensitizer 138 CIR

139

Panel 3.87% Mangifera Indica (Mango) Seed Oil in an eyeliner 102 HRIPT with 0.2 g of test material, semi-occluded not a dermal irritant or sensitizer

140

Book 2% Mangifera Indica (Mango) Seed Oil in a lipstick 100 HRIPT with 150 µl test material, semi-occluded not a dermal irritant or sensitizer 9% Mangifera Indica (Mango) Seed Butter in a body 141 Page product 102 HRIPT with 0.2 g, semi-occluded not a sensitizer 1% Mangifera Indica (Mango) Seed Butter in a facial 55 lotion 100 HRIPT with 200 µl test material, semi-occluded not a dermal irritant or sensitizer 142

3% Moringa Pterygosperna Seed Oil in an eye treatment 104 HRIPT with 150 µl test material, semi-occluded not a dermal irritant or sensitizer 143 1.99% Oenothera Biennis (Evening Primrose) Oil in a foundation 600 HRIPT, occluded not a dermal irritant or sensitizer 144 22% Olea Europaea (Olive) Fruit Oil in a body moisturizer 105 HRIPT, semi-occluded not a dermal irritant or sensitizer 145 58.7% Olea Europaea (Olive) Fruit Oil in a conditioning hair oil 102 HRIPT with 0.2 ml, semi-occluded not a dermal irritant or sensitizer 146

5% Hydrogenated Olive Oil Unsaponifiables in a skin cleansing product 57 HRIPT, semi-occluded, 10% dilution not a dermal irritation or sensitizer 135

2% Hydrogenated Olive Oil Unsaponifiables in a face and neck product 50 HRIPT, occluded not a dermal irritation or sensitizer 135

12% Hydrogenated Olive Oil in a lipstick 108 HRIPT, occluded not a dermal irritant or sensitizer 136 2.5% Olea Europaea (Olive) Oil Unsaponfiables in a bath body mist 107 HRIPT with 150 µl test material, semi-occluded not a dermal irritant or sensitizer 147 46

Table 7. Clinical irritation and sensitization studies on vegetable oils. Ingredient and Concentration Subjects Completed Method Results Reference

17.64% Sodium Olivate in a body bar soap 107 HRIPT, semi-occluded not a dermal irritant or sensitizer 148

3.79% Orbignya Oleifera Seed Oil in a cream cleanser 104 HRIPT with 0.2 ml of a 10% dilution , semi-occluded not a dermal irritant or sensitizer 149

0.04% Prunus Domestica Seed Oil in a preshave lotion 105 HRIPT with 0.2 ml, occluded not a sensitizer 150

4 subjects had "?" or "+" reaction during induction that were not considered clinically relevant, no 0.2% Ribes Nigrum (Black Currant) Seed Oil is an eye other reactions observed. Not mask 228 HRIPT, occluded sensitizing 151 No adverse reactions reported. 0.2% Ribes Nigrum (Black Currant) Seed Oil is an eye Product considered suitable for mask 195 4-week safety in-use study sensitive skin. 152

Rubus Idaeus (Raspberry) Seed Oil in a face and neck 135

CIR product (concentration not reported) 102 HRIPT, occluded not a dermal irritation or sensitizer Panel 0.0023% Solanum Lycopersicum (Tomato) Seed Oil in a cream cleanser 104 HRIPT with 0.2 ml of a 10% dilution , semi-occluded not a dermal irritant or sensitizer 153 Book 50.1% Theobroma Cacao (Cocoa) Seed Butter in a lip balm 106 HRIPT with 150 µl test material, semi-occluded not a dermal irritant or sensitizer 154 Page

5% Theobroma Grandiflorum Seed Butter in a lip balm 106 HRIPT with 150 µl test material, semi-occluded not a dermal irritant or sensitizer 155 56

0.04% Vaccinium Macrocarpon (Cranberry) Seed Oil in a face and neck product 53 HRIPT, occluded not a dermal irritation or sensitizer 135

1 subject had + on the first day of the induction only, no other reactions. Not 4% Vegetable Oil in a foundation 115 HRIPT, semi-occluded adermal irritant or sensitizer. 156

4% Vegetable Oil in a lipstick 106 HRIPT with 0.2 g, occluded not a dermal irritant or sensitizer 157 11% Vegetable Oil in an eye shadow 106 HRIPT, semi-occluded not a dermal irritant or sensitizer 158

39% Vitis Vinifera (Grape )Seed Oil in a preshave lotion 105 HRIPT with 0.2 ml, occluded not a sensitizer 150

0.5% Hydrogenated Grapeseed Oil in a lip product 53 HRIPT, semi-occluded not a dermal irritation or sensitizer 159

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84. John L. Seaton & Co, Ltd. Seatons Rice Bran Oil data sheet. 2005. John L. Seaton & Co, Ltd.

85. John L. Seaton & Co, Ltd. Seatons Cherry Kernel Oil data sheet. 2005. John L. Seaton & Co. Ltd.

86. John L. Seaton & Co, Ltd. Seatons Refined Cherry Kernel Oil specifications. 2009. John L. Seaton & Co., Ltd.

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89. John L. Seaton & Co, Ltd. Seatons Borage Oil data sheet. 2005. John L. Seaton & Co., Ltd.

90. John L. Seaton & Co, Ltd. Seatons Refined Borage Oil specifications. 2009. John L. Seaton & Co., Ltd.

91. John L. Seaton & Co, Ltd. Seatons Camellia Seed Oil data sheet. 2007. John L. Seaton & Co, Ltd.

92. John L. Seaton & Co, Ltd. Seatons Camellia Seed Oil specifications. 2005. John L. Seaton & Co., Ltd.

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104. John L. Seaton & Co, Ltd. Seatons Refined Cranberry Seed Oil specification. 2008. John L. Seaton & Co., Ltd.

105. John L. Seaton & Co, Ltd. Seatons Evening Primrose Oil data sheet. 2005. John L. Seaton & Co., Ltd.

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107. John L. Seaton & Co, Ltd. Seatons Plum Oil data sheet. 2005. John L. Seaton & Co., Ltd.

108. John L. Seaton & Co, Ltd. Seatons Virgin Plum Oil specification. 2010. John L. Seaton & Co., Ltd.

109. John L. Seaton & Co, Ltd. Seatons Blackcurrant Seed Oil specification. 2005. John L. Seaton & Co., Ltd.

110. John L. Seaton & Co, Ltd. Seatons Refined Blackcurrant Seed Oil specification. 2010. John L. Seaton & Co., Ltd.

111. John L. Seaton & Co, Ltd. Seatons Red Raspberry Seed Oil data sheet. 2007. John L. Seaton & Co., Ltd.

112. John L. Seaton & Co, Ltd. Seatons Refined Red Raspberry Seed Oil specification. 2006. John L. Seaton & Co., Ltd.

113. John L. Seaton & Co, Ltd. Seatons Moringa Oil data sheet. 2005. John L. Seaton & Co., Ltd.

114. John L. Seaton & Co, Ltd. Seatons Refined Moringa Oil specification. 2006. John L. Seaton & Co., Ltd.

115. John L. Seaton & Co, Ltd. Seatons Refined Rice Bran Oil specifications. 2009. John L. Seaton & Co, Ltd.

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121. Clinical Research Laboratories, Inc. Repeated insult patch test on a lipstick formulation containing 4% Astrocaryum Murumura Seed Butter. CRL study no.: CRL69608-6. Unpublished data. 8-1-2008.

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125. RCTS, Inc. Clinical safety evaluation. Human repeated insult patch test with a body and hand formulation containing 3% Avena Sativa (Oat) Kernel Oil. RCTS study no.: 1712 &1714. Unpublished data. 9-8-2004.

126. TKL Research. Repeated insult patch test on a body and hand formulation containng 1% Borago Officinalis Seed Oil. TKL study o.: DS103107/103507. 6-22-2007.

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127. Consumer Product Testing Co. Repeated insult patch test of a baby oil containing 5% hydrogenated rapeseed oil. Unpublished data. 1999.

128. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of a hair conditioner (containing 0.5% Brassica Oleracea Italica (Broccoli) Seed Oil) on human skin. Unpublished data. 11-11- 2008. Product Investigations, Inc.

129. Consumer Product Testing Co. Repeated insult patch test on a lipstick containing 0.0985% Camellia Sinensis Seed Oil. Ref. No.: C08-5394.07. 2008.

130. Consumer Product Testing Co. Repeated insult parch test of a lipstick containing 0.0985% Camellia Sinensis Seed OIl. Ref. No. C08-5394.08. 2008.

131. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of a body oil (containing 74.7% Canola Oil) on human skin. Unpublished data. 2005. Product Investigations, Inc.

132. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of a lipstick (containing 0.1% Caryocar Brasilienses Fruit Oil) on human skin. Unpublished data. 2009. Products Investigations, Inc.

133. Clinical Research Laboratories, Inc. Repeated insult patch test of a facial oil containing 2% Citrullus Lanatus (Watermelono) Seed Oil. Unpublished data. 2009. Clinical Research Laboratories, Inc.

134. Product Investigations, Inc. Determination of the irritating and senstizing propensities of an eye treatment (containing 0.5% Euterpe Oleracea Fruit Oil) on human skin. Unpublished data. 2007. Product Investigations, Inc.

135. Personal Care Products Council. Summaries of HRIPT studies of products containing plant oils. Unpublished data. 6-1-2010.

136. Clinical Research Laboratories, Inc. Repeated insult patch test on a lipstick containing 39% Hydrogenated Soybean Oil and 12% Hydrogenated Olive Oil. CRL study no.: CRL128208-13. Unpublished data. 12-24-2008.

137. Clinical Research Laboratories, Inc. Repeated insult patch test of a facial repair product containing 71.3% Limnanthes Alba (Meadowfoam) Seed Oil. Unpublished data. 2005. Clinical Research Laboratories, Inc.

138. Consumer Product Testing Co. Repeated insult patch test on a mascara containing Linum Usitatissiumum (Linseed) Seed Oil at 9.4%. Experiment reference number: C08-3409.02. Unpublished data. 9-10-2008.

139. Consumer Product Testing Co. Repeated insult patch test protocol of an eyeliner containing 3.87% Mangifera Indica (Mango) Seed Oil. Unpublished data. 2004. Consumer Product Testing Co.

140. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of lipstick (containing 2% Mangifera Indica (Mango) Seed Oil) on human skin. Unpublished data. 2003. Product Investigations, Inc.

141. TKL Research. Repeated insult patch test of a body product containing 9% Mangifera Indican (Mango) Seed Butter. Unpublished data. 2001.

142. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of a facial lotion (containing 1% Mangifera Indica (Mango) Seed Butter) on human skin. Unpublished data. 2009. Product Investigations, Inc.

143. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of an eye treatment (containing 3% Moringa Pterygosperm Seed Oil) on human skin. Unpublished data. 2007. Product Investigations, Inc.

144. Orentreich Research Corporation. Predictive patch test study of a foundation containing 1.99% Oenothera Biennis (Evening Primrose) Oil. Unpublished data. 2007.

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145. Clinical Research Laboratories, Inc. Repeated insult patch test on a body moisturizer containing 22% Olea Europaea (Olive) Fruit Oil. Unpublished data. 2007.

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147. Product Investigations, Inc. Determination of the irritating and sensitizing propensities on human skin for a frgranced body mist containing 2.5% Olea Europaea (Olive) Oil Unsaponifiables. Unpublished data. 2007.

148. Clinical Research Laboratories, Inc. Repeated insult patch test of a body bar soap containng 17.64% sodium olivate. Unpublished data. 2008.

149. Consumer Product Testing Co. Repeated insult patch test of a cream cleanser containing 3.79% Orbignya Oleifera Seed Oil. Unpublished data. 2006. Consumer Product Testing Co.

150. TKL Research. Repeated insult patch test of a preshave lotion containing 39% Vitis Vinifera (Grape) Seed Oil and 0.04% Prunus Domestica Seed Oil. TKL Study No: DS109206-3. Unpublished data. 2-15-2007.

151. TKL Reseach. HRIPT of an eye mask containing 0.2% Ribes Nigrum (Black Currant) Seed Oil. RIPT 07-7331-036. Unpublished data (summary). 2007.

152. Q Research. 4-week use study of an eye mask containing 0.2% Ribes Nigrum (Black Currant) Seed Oil. Use 07- 7331-056. Unpublished data (summary). 2007.

153. Consumer Product Testing Co. Repeated insult patch test of a cream cleanser containing 0.0023% Solanum Lycopersicum (Tomato) Seed Oil. Unpublished data. 2006. Consumer Product Testing, Co.

154. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of a lip balm (containing 50.1% Theobroma Cacao (Cocoa) Seed Butter) on human skin. Unpublished data. 2006. Product Investigations, Inc.

155. Product Investigations, Inc. Determination of the irritating and sensitizing propensities of a lip balm (containing 5% Theobroma Grandiflorum Seed Butter) on human skin. Unpublished data. 2008. Product Investigations, Inc.

156. Clinical Research Laboratories, Inc. Repeated insult patch test of a foundation containing 4% Vegetable Oil. Unpublished data. 2005. Clinical Research Laboratories, Inc.

157. Consumer Product Testing Co. Exclusive repeated insult patchtest on a lipstick containing 4% vegetable oil. Ref. No. C07-0193.12. Unpublished data. 2007.

158. Clinical Research Laboratories, Inc. Repeated insult patch test of an eye shadow containing 11% vegetable oil. CRL study number: CRL14606-4. Unpublished data. 3-30-2006.

159. Clinical Research Laboratories, Inc. Repeated insult patch test of a lip product containing 0.5% hydrogenated grapeseed oil. CRL study number: CRL88908-5. Unpublished data. 9-8-2008.

CIR Panel Book Page 64 Data

CIR Panel Book Page 65 2010 FDA VCRP Raw Data

VEGETABLE FATTY ACID 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests) 17 VEGETABLE FATTY ACID 07E - Lipstick 3 VEGETABLE FATTY ACID 12F - Moisturizing 1 VEGETABLE OIL 01B - Baby Lotions, Oils, Powders, and Creams 1 VEGETABLE OIL 02A - Bath Oils, Tablets, and Salts 1 VEGETABLE OIL 02D - Other Bath Preparations 1 VEGETABLE OIL 03C - Eye Shadow 1 VEGETABLE OIL 03D - Eye Lotion 1 VEGETABLE OIL 03F - Mascara 2 VEGETABLE OIL 03G - Other Eye Makeup Preparations 7 VEGETABLE OIL 04E - Other Fragrance Preparation 1 VEGETABLE OIL 05F - Shampoos (non-coloring) 1 VEGETABLE OIL 06H - Other Hair Coloring Preparation 1 VEGETABLE OIL 07C - Foundations 3 VEGETABLE OIL 07E - Lipstick 71 VEGETABLE OIL 07I - Other Makeup Preparations 6 VEGETABLE OIL 08C - Nail Creams and Lotions 1 VEGETABLE OIL 10A - Bath Soaps and Detergents 1 VEGETABLE OIL 12A - Cleansing 5 VEGETABLE OIL 12C - Face and Neck (exc shave) 5 VEGETABLE OIL 12D - Body and Hand (exc shave) 7 VEGETABLE OIL 12F - Moisturizing 8 VEGETABLE OIL 12G - Night 4 VEGETABLE OIL 12H - Paste Masks (mud packs) 3 VEGETABLE OIL 12J - Other Skin Care Preps 10 VEGETABLE OIL 13A - Suntan Gels, Creams, and Liquids 3

HYDROGENATED VEGETABLE OIL 03A - Eyebrow Pencil 29 HYDROGENATED VEGETABLE OIL 03B - Eyeliner 38 HYDROGENATED VEGETABLE OIL 03C - Eye Shadow 11 HYDROGENATED VEGETABLE OIL 03D - Eye Lotion 9 HYDROGENATED VEGETABLE OIL 03F - Mascara 4 HYDROGENATED VEGETABLE OIL 03G - Other Eye Makeup Preparations 11 HYDROGENATED VEGETABLE OIL 04E - Other Fragrance Preparation 1 HYDROGENATED VEGETABLE OIL 05A - Hair Conditioner 2 HYDROGENATED VEGETABLE OIL 07B - Face Powders 1 HYDROGENATED VEGETABLE OIL 07C - Foundations 8 HYDROGENATED VEGETABLE OIL 07E - Lipstick 216 HYDROGENATED VEGETABLE OIL 07I - Other Makeup Preparations 27 HYDROGENATED VEGETABLE OIL 08B - Cuticle Softeners 1 HYDROGENATED VEGETABLE OIL 10A - Bath Soaps and Detergents 1 HYDROGENATED VEGETABLE OIL 10E - Other Personal Cleanliness Products 1 HYDROGENATED VEGETABLE OIL 12A - Cleansing 12 HYDROGENATED VEGETABLE OIL 12C - Face and Neck (exc shave) 7 HYDROGENATED VEGETABLE OIL 12D - Body and Hand (exc shave) 21 HYDROGENATED VEGETABLE OIL 12E - Foot Powders and Sprays 1 HYDROGENATED VEGETABLE OIL 12F - Moisturizing 30 HYDROGENATED VEGETABLE OIL 12G - Night 7 HYDROGENATED VEGETABLE OIL 12H - Paste Masks (mud packs) 2 HYDROGENATED VEGETABLE OIL 12J - Other Skin Care Preps 15 HYDROGENATED VEGETABLE OIL 13B - Indoor Tanning Preparations 1 HYDROGENATED VEGETABLE OIL 13C - Other Suntan Preparations 1

BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 03D - Eye Lotion 1 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 03G - Other Eye Makeup Preparations 1 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 07E - Lipstick 1 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 10E - Other Personal Cleanliness Products 1 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 12A - Cleansing 3 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 12C - Face and Neck (exc shave) 4 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 12D - Body and Hand (exc shave) 9 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 12F - Moisturizing 3 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 12G - Night 1 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 12J - Other Skin Care Preps 1 BRASSICA CAMPESTRIS (RAPESEED) SEED OIL 13B - Indoor Tanning Preparations 2

CIR Panel Book Page 66 2010 FDA VCRP Raw Data

HYDROGENATED RAPESEED OIL 12A - Cleansing 1

CANOLA OIL 02A - Bath Oils, Tablets, and Salts 1 CANOLA OIL 03B - Eyeliner 1 CANOLA OIL 03C - Eye Shadow 1 CANOLA OIL 03D - Eye Lotion 1 CANOLA OIL 05A - Hair Conditioner 6 CANOLA OIL 05F - Shampoos (non-coloring) 2 CANOLA OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 7 CANOLA OIL 05I - Other Hair Preparations 4 CANOLA OIL 07E - Lipstick 62 CANOLA OIL 07I - Other Makeup Preparations 4 CANOLA OIL 10A - Bath Soaps and Detergents 2 CANOLA OIL 11G - Other Shaving Preparation Products 1 CANOLA OIL 12A - Cleansing 4 CANOLA OIL 12D - Body and Hand (exc shave) 13 CANOLA OIL 12E - Foot Powders and Sprays 1 CANOLA OIL 12F - Moisturizing 15 CANOLA OIL 12G - Night 2 CANOLA OIL 12J - Other Skin Care Preps 5

HYDROGENATED CANOLA OIL 12A - Cleansing 1 HYDROGENATED CANOLA OIL 12J - Other Skin Care Preps 2

PALM KERNEL ACID 04E - Other Fragrance Preparation 1 PALM KERNEL ACID 05F - Shampoos (non-coloring) 1 PALM KERNEL ACID 10A - Bath Soaps and Detergents 61 PALM KERNEL ACID 10E - Other Personal Cleanliness Products 3 PALM KERNEL ACID 11F - Shaving Soap 2 PALM KERNEL ACID 12A - Cleansing 2 PALM KERNEL ACID 12I - Skin Fresheners 2

ELAEIS OLEIFERA KERNEL OIL 05E - Rinses (non-coloring) 1 ELAEIS OLEIFERA KERNEL OIL 05I - Other Hair Preparations 1 ELAEIS OLEIFERA KERNEL OIL 06H - Other Hair Coloring Preparation 3

PALM ACID 04E - Other Fragrance Preparation 1 PALM ACID 10A - Bath Soaps and Detergents 31 PALM ACID 12A - Cleansing 1

PALM FATTY ACID 10A - Bath Soaps and Detergents 27 PALM FATTY ACID 12A - Cleansing 2

POTASSIUM PALMATE 10A - Bath Soaps and Detergents 2 POTASSIUM PALMATE 11F - Shaving Soap 3

POTASSIUM PALM KERNELATE 10A - Bath Soaps and Detergents 1 POTASSIUM PALM KERNELATE 10E - Other Personal Cleanliness Products 3 POTASSIUM PALM KERNELATE 11F - Shaving Soap 3

SODIUM PALMATE 01C - Other Baby Products 3 SODIUM PALMATE 02D - Other Bath Preparations 1 SODIUM PALMATE 04E - Other Fragrance Preparation 1 SODIUM PALMATE 10A - Bath Soaps and Detergents 184 SODIUM PALMATE 10E - Other Personal Cleanliness Products 5

CIR Panel Book Page 67 2010 FDA VCRP Raw Data

SODIUM PALMATE 11F - Shaving Soap 5 SODIUM PALMATE 12A - Cleansing 10 SODIUM PALMATE 12C - Face and Neck (exc shave) 2 SODIUM PALMATE 12H - Paste Masks (mud packs) 1

SODIUM PALM KERNELATE 01C - Other Baby Products 4 SODIUM PALM KERNELATE 02D - Other Bath Preparations 3 SODIUM PALM KERNELATE 04E - Other Fragrance Preparation 1 SODIUM PALM KERNELATE 10A - Bath Soaps and Detergents 169 SODIUM PALM KERNELATE 10E - Other Personal Cleanliness Products 4 SODIUM PALM KERNELATE 11A - Aftershave Lotion 1 SODIUM PALM KERNELATE 11F - Shaving Soap 3 SODIUM PALM KERNELATE 12A - Cleansing 5 SODIUM PALM KERNELATE 12J - Other Skin Care Preps 4

GLYCINE SOJA (SOYBEAN) OIL 01A - Baby Shampoos 1 GLYCINE SOJA (SOYBEAN) OIL 01B - Baby Lotions, Oils, Powders, and Creams 17 GLYCINE SOJA (SOYBEAN) OIL 01C - Other Baby Products 3 GLYCINE SOJA (SOYBEAN) OIL 02A - Bath Oils, Tablets, and Salts 13 GLYCINE SOJA (SOYBEAN) OIL 02B - Bubble Baths 1 GLYCINE SOJA (SOYBEAN) OIL 02D - Other Bath Preparations 5 GLYCINE SOJA (SOYBEAN) OIL 03B - Eyeliner 7 GLYCINE SOJA (SOYBEAN) OIL 03C - Eye Shadow 20 GLYCINE SOJA (SOYBEAN) OIL 03D - Eye Lotion 13 GLYCINE SOJA (SOYBEAN) OIL 03E - Eye Makeup Remover 2 GLYCINE SOJA (SOYBEAN) OIL 03F - Mascara 3 GLYCINE SOJA (SOYBEAN) OIL 03G - Other Eye Makeup Preparations 8 GLYCINE SOJA (SOYBEAN) OIL 04E - Other Fragrance Preparation 3 GLYCINE SOJA (SOYBEAN) OIL 05A - Hair Conditioner 25 GLYCINE SOJA (SOYBEAN) OIL 05B - Hair Spray (aerosol fixatives) 2 GLYCINE SOJA (SOYBEAN) OIL 05F - Shampoos (non-coloring) 19 GLYCINE SOJA (SOYBEAN) OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 23 GLYCINE SOJA (SOYBEAN) OIL 05H - Wave Sets 1 GLYCINE SOJA (SOYBEAN) OIL 05I - Other Hair Preparations 27 GLYCINE SOJA (SOYBEAN) OIL 06C - Hair Rinses (coloring) 5 GLYCINE SOJA (SOYBEAN) OIL 07A - Blushers (all types) 12 GLYCINE SOJA (SOYBEAN) OIL 07B - Face Powders 21 GLYCINE SOJA (SOYBEAN) OIL 07C - Foundations 22 GLYCINE SOJA (SOYBEAN) OIL 07E - Lipstick 103 GLYCINE SOJA (SOYBEAN) OIL 07F - Makeup Bases 3 GLYCINE SOJA (SOYBEAN) OIL 07G - Rouges 14 GLYCINE SOJA (SOYBEAN) OIL 07H - Makeup Fixatives 1 GLYCINE SOJA (SOYBEAN) OIL 07I - Other Makeup Preparations 19 GLYCINE SOJA (SOYBEAN) OIL 08B - Cuticle Softeners 2 GLYCINE SOJA (SOYBEAN) OIL 08E - Nail Polish and Enamel 2 GLYCINE SOJA (SOYBEAN) OIL 08G - Other Manicuring Preparations 2 GLYCINE SOJA (SOYBEAN) OIL 10A - Bath Soaps and Detergents 23 GLYCINE SOJA (SOYBEAN) OIL 10E - Other Personal Cleanliness Products 47 GLYCINE SOJA (SOYBEAN) OIL 11A - Aftershave Lotion 1 GLYCINE SOJA (SOYBEAN) OIL 11D - Preshave Lotions (all types) 1 GLYCINE SOJA (SOYBEAN) OIL 11E - Shaving Cream 2 GLYCINE SOJA (SOYBEAN) OIL 11G - Other Shaving Preparation Products 2 GLYCINE SOJA (SOYBEAN) OIL 12A - Cleansing 36 GLYCINE SOJA (SOYBEAN) OIL 12B - Depilatories 4 GLYCINE SOJA (SOYBEAN) OIL 12C - Face and Neck (exc shave) 50 GLYCINE SOJA (SOYBEAN) OIL 12D - Body and Hand (exc shave) 82 GLYCINE SOJA (SOYBEAN) OIL 12E - Foot Powders and Sprays 1 GLYCINE SOJA (SOYBEAN) OIL 12F - Moisturizing 152 GLYCINE SOJA (SOYBEAN) OIL 12G - Night 19 GLYCINE SOJA (SOYBEAN) OIL 12H - Paste Masks (mud packs) 7 GLYCINE SOJA (SOYBEAN) OIL 12I - Skin Fresheners 9 GLYCINE SOJA (SOYBEAN) OIL 12J - Other Skin Care Preps 49 GLYCINE SOJA (SOYBEAN) OIL 13A - Suntan Gels, Creams, and Liquids 7

CIR Panel Book Page 68 2010 FDA VCRP Raw Data

GLYCINE SOJA (SOYBEAN) OIL 13B - Indoor Tanning Preparations 19 GLYCINE SOJA (SOYBEAN) OIL 13C - Other Suntan Preparations 2

EPOXIDIZED SOYBEAN OIL 08A - Basecoats and Undercoats 1 EPOXIDIZED SOYBEAN OIL 08E - Nail Polish and Enamel 3 EPOXIDIZED SOYBEAN OIL 08G - Other Manicuring Preparations 1

GLYCINE SOJA (SOYBEAN) OIL UNSAPONIFIABLES 07C - Foundations 1 GLYCINE SOJA (SOYBEAN) OIL UNSAPONIFIABLES 12C - Face and Neck (exc shave) 7 GLYCINE SOJA (SOYBEAN) OIL UNSAPONIFIABLES 12D - Body and Hand (exc shave) 1 GLYCINE SOJA (SOYBEAN) OIL UNSAPONIFIABLES 12J - Other Skin Care Preps 3

HYDROGENATED SOYBEAN OIL 03B - Eyeliner 1 HYDROGENATED SOYBEAN OIL 03C - Eye Shadow 1 HYDROGENATED SOYBEAN OIL 03D - Eye Lotion 1 HYDROGENATED SOYBEAN OIL 03G - Other Eye Makeup Preparations 1 HYDROGENATED SOYBEAN OIL 05F - Shampoos (non-coloring) 1 HYDROGENATED SOYBEAN OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 HYDROGENATED SOYBEAN OIL 07D - Leg and Body Paints 1 HYDROGENATED SOYBEAN OIL 07E - Lipstick 3 HYDROGENATED SOYBEAN OIL 07I - Other Makeup Preparations 3 HYDROGENATED SOYBEAN OIL 12A - Cleansing 2 HYDROGENATED SOYBEAN OIL 12C - Face and Neck (exc shave) 4 HYDROGENATED SOYBEAN OIL 12D - Body and Hand (exc shave) 7 HYDROGENATED SOYBEAN OIL 12F - Moisturizing 8 HYDROGENATED SOYBEAN OIL 12J - Other Skin Care Preps 2

HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 01A - Baby Shampoos 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 16 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 01C - Other Baby Products 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 02A - Bath Oils, Tablets, and Salts 3 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 02B - Bubble Baths 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 02C - Bath Capsules 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 02D - Other Bath Preparations 6 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 03B - Eyeliner 12 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 03C - Eye Shadow 17 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 03D - Eye Lotion 21 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 03F - Mascara 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 03G - Other Eye Makeup Preparations 13 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 04E - Other Fragrance Preparation 12 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 05A - Hair Conditioner 68 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 05B - Hair Spray (aerosol fixatives) 4 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 05C - Hair Straighteners 3 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 05F - Shampoos (non-coloring) 30 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 25 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 05H - Wave Sets 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 05I - Other Hair Preparations 48 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests) 81 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 06G - Hair Bleaches 3 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 06H - Other Hair Coloring Preparation 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 07A - Blushers (all types) 23 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 07B - Face Powders 7 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 07C - Foundations 19 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 07E - Lipstick 260 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 07H - Makeup Fixatives 2 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 07I - Other Makeup Preparations 19 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 08A - Basecoats and Undercoats 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 08B - Cuticle Softeners 2 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 08C - Nail Creams and Lotions 2 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 08G - Other Manicuring Preparations 3 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 10A - Bath Soaps and Detergents 46 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 10B - Deodorants (underarm) 1

CIR Panel Book Page 69 2010 FDA VCRP Raw Data

HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 10E - Other Personal Cleanliness Products 52 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 11A - Aftershave Lotion 2 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 11E - Shaving Cream 7 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 11G - Other Shaving Preparation Products 2 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12A - Cleansing 34 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12B - Depilatories 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12C - Face and Neck (exc shave) 93 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12D - Body and Hand (exc shave) 100 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12E - Foot Powders and Sprays 3 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12F - Moisturizing 225 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12G - Night 25 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12H - Paste Masks (mud packs) 19 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12I - Skin Fresheners 2 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 12J - Other Skin Care Preps 76 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 13A - Suntan Gels, Creams, and Liquids 4 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 13B - Indoor Tanning Preparations 9 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL 13C - Other Suntan Preparations 6

HYBRID SUNFLOWER SEED OIL 07E - Lipstick 1

HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL UNSAPONIFIABLES03B - Eyeliner 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL UNSAPONIFIABLES12C - Face and Neck (exc shave) 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL UNSAPONIFIABLES12G - Night 1 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL UNSAPONIFIABLES13A - Suntan Gels, Creams, and Liquids 2 HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL UNSAPONIFIABLES13B - Indoor Tanning Preparations 1 SUNFLOWER OIL, UNSAPONIFIABLE FRACTION 03G - Other Eye Makeup Preparations 1 SUNFLOWER OIL, UNSAPONIFIABLE FRACTION 12D - Body and Hand (exc shave) 1 SUNFLOWER OIL, UNSAPONIFIABLE FRACTION 12I - Skin Fresheners 1 SUNFLOWER OIL, UNSAPONIFIABLE FRACTION 13A - Suntan Gels, Creams, and Liquids 1

OLEA EUROPAEA (OLIVE) FRUIT OIL 01B - Baby Lotions, Oils, Powders, and Creams 7 OLEA EUROPAEA (OLIVE) FRUIT OIL 01C - Other Baby Products 2 OLEA EUROPAEA (OLIVE) FRUIT OIL 02A - Bath Oils, Tablets, and Salts 7 OLEA EUROPAEA (OLIVE) FRUIT OIL 02D - Other Bath Preparations 7 OLEA EUROPAEA (OLIVE) FRUIT OIL 03B - Eyeliner 1 OLEA EUROPAEA (OLIVE) FRUIT OIL 03C - Eye Shadow 3 OLEA EUROPAEA (OLIVE) FRUIT OIL 03D - Eye Lotion 6 OLEA EUROPAEA (OLIVE) FRUIT OIL 03F - Mascara 9 OLEA EUROPAEA (OLIVE) FRUIT OIL 03G - Other Eye Makeup Preparations 7 OLEA EUROPAEA (OLIVE) FRUIT OIL 04A - Cologne and Toilet waters 2 OLEA EUROPAEA (OLIVE) FRUIT OIL 04E - Other Fragrance Preparation 4 OLEA EUROPAEA (OLIVE) FRUIT OIL 05A - Hair Conditioner 54 OLEA EUROPAEA (OLIVE) FRUIT OIL 05C - Hair Straighteners 8 OLEA EUROPAEA (OLIVE) FRUIT OIL 05F - Shampoos (non-coloring) 39 OLEA EUROPAEA (OLIVE) FRUIT OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 55 OLEA EUROPAEA (OLIVE) FRUIT OIL 05I - Other Hair Preparations 34 OLEA EUROPAEA (OLIVE) FRUIT OIL 07A - Blushers (all types) 9 OLEA EUROPAEA (OLIVE) FRUIT OIL 07B - Face Powders 6 OLEA EUROPAEA (OLIVE) FRUIT OIL 07C - Foundations 3 OLEA EUROPAEA (OLIVE) FRUIT OIL 07E - Lipstick 26 OLEA EUROPAEA (OLIVE) FRUIT OIL 07F - Makeup Bases 3 OLEA EUROPAEA (OLIVE) FRUIT OIL 07I - Other Makeup Preparations 10 OLEA EUROPAEA (OLIVE) FRUIT OIL 08B - Cuticle Softeners 2 OLEA EUROPAEA (OLIVE) FRUIT OIL 08C - Nail Creams and Lotions 1 OLEA EUROPAEA (OLIVE) FRUIT OIL 08E - Nail Polish and Enamel 1 OLEA EUROPAEA (OLIVE) FRUIT OIL 08G - Other Manicuring Preparations 1 OLEA EUROPAEA (OLIVE) FRUIT OIL 10A - Bath Soaps and Detergents 95 OLEA EUROPAEA (OLIVE) FRUIT OIL 10B - Deodorants (underarm) 3 OLEA EUROPAEA (OLIVE) FRUIT OIL 10E - Other Personal Cleanliness Products 26 OLEA EUROPAEA (OLIVE) FRUIT OIL 11A - Aftershave Lotion 1 OLEA EUROPAEA (OLIVE) FRUIT OIL 11B - Beard Softeners 1 OLEA EUROPAEA (OLIVE) FRUIT OIL 11E - Shaving Cream 12 OLEA EUROPAEA (OLIVE) FRUIT OIL 11F - Shaving Soap 2

CIR Panel Book Page 70 2010 FDA VCRP Raw Data

OLEA EUROPAEA (OLIVE) FRUIT OIL 11G - Other Shaving Preparation Products 2 OLEA EUROPAEA (OLIVE) FRUIT OIL 12A - Cleansing 40 OLEA EUROPAEA (OLIVE) FRUIT OIL 12C - Face and Neck (exc shave) 58 OLEA EUROPAEA (OLIVE) FRUIT OIL 12D - Body and Hand (exc shave) 111 OLEA EUROPAEA (OLIVE) FRUIT OIL 12F - Moisturizing 183 OLEA EUROPAEA (OLIVE) FRUIT OIL 12G - Night 9 OLEA EUROPAEA (OLIVE) FRUIT OIL 12H - Paste Masks (mud packs) 6 OLEA EUROPAEA (OLIVE) FRUIT OIL 12J - Other Skin Care Preps 35 OLEA EUROPAEA (OLIVE) FRUIT OIL 13A - Suntan Gels, Creams, and Liquids 3 OLEA EUROPAEA (OLIVE) FRUIT OIL 13B - Indoor Tanning Preparations 18 OLEA EUROPAEA (OLIVE) FRUIT OIL 13C - Other Suntan Preparations 3

HYDROGENATED OLIVE OIL 03B - Eyeliner 1 HYDROGENATED OLIVE OIL 03C - Eye Shadow 1 HYDROGENATED OLIVE OIL 03D - Eye Lotion 1 HYDROGENATED OLIVE OIL 03F - Mascara 5 HYDROGENATED OLIVE OIL 03G - Other Eye Makeup Preparations 5 HYDROGENATED OLIVE OIL 05A - Hair Conditioner 4 HYDROGENATED OLIVE OIL 05F - Shampoos (non-coloring) 6 HYDROGENATED OLIVE OIL 05I - Other Hair Preparations 1 HYDROGENATED OLIVE OIL 07E - Lipstick 7 HYDROGENATED OLIVE OIL 10A - Bath Soaps and Detergents 1 HYDROGENATED OLIVE OIL 11F - Shaving Soap 1 HYDROGENATED OLIVE OIL 12A - Cleansing 1 HYDROGENATED OLIVE OIL 12C - Face and Neck (exc shave) 3 HYDROGENATED OLIVE OIL 12D - Body and Hand (exc shave) 2 HYDROGENATED OLIVE OIL 12F - Moisturizing 4 HYDROGENATED OLIVE OIL 12G - Night 2 HYDROGENATED OLIVE OIL 12I - Skin Fresheners 3 HYDROGENATED OLIVE OIL 12J - Other Skin Care Preps 2

HYDROGENATED OLIVE OIL UNSAPONIFIABLES 07C - Foundations 1 HYDROGENATED OLIVE OIL UNSAPONIFIABLES 12D - Body and Hand (exc shave) 1

OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 03D - Eye Lotion 2 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 03F - Mascara 4 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 03G - Other Eye Makeup Preparations 6 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 05A - Hair Conditioner 2 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 05C - Hair Straighteners 1 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 05F - Shampoos (non-coloring) 2 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 05I - Other Hair Preparations 1 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 07B - Face Powders 1 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 07E - Lipstick 1 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 07I - Other Makeup Preparations 2 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 10A - Bath Soaps and Detergents 4 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 12C - Face and Neck (exc shave) 14 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 12D - Body and Hand (exc shave) 2 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 12F - Moisturizing 26 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 12G - Night 4 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 12J - Other Skin Care Preps 3 OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES 13C - Other Suntan Preparations 2

OLIVE OIL FATTY ACIDS, POTASSIUM SALTS 10E - Other Personal Cleanliness Products 1 OLIVE OIL FATTY ACIDS, POTASSIUM SALTS 11E - Shaving Cream 2

SODIUM OLIVATE 01C - Other Baby Products 1 SODIUM OLIVATE 10A - Bath Soaps and Detergents 9 SODIUM OLIVATE 11E - Shaving Cream 2 SODIUM OLIVATE 12J - Other Skin Care Preps 4

CIR Panel Book Page 71 2010 FDA VCRP Raw Data

ACTINIDIA CHINENSIS (KIWI) SEED OIL 04E - Other Fragrance Preparation 1 ACTINIDIA CHINENSIS (KIWI) SEED OIL 05A - Hair Conditioner 2 ACTINIDIA CHINENSIS (KIWI) SEED OIL 07E - Lipstick 1 ACTINIDIA CHINENSIS (KIWI) SEED OIL 12G - Night 3

ADANSONIA DIGITATA SEED OIL 01A - Baby Shampoos 1 ADANSONIA DIGITATA SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 1 ADANSONIA DIGITATA SEED OIL 12F - Moisturizing 2 ADANSONIA DIGITATA SEED OIL 12H - Paste Masks (mud packs) 1 ADANSONIA DIGITATA SEED OIL 12J - Other Skin Care Preps 1

ARGANIA SPINOSA KERNEL OIL 02D - Other Bath Preparations 1 ARGANIA SPINOSA KERNEL OIL 03A - Eyebrow Pencil 1 ARGANIA SPINOSA KERNEL OIL 03B - Eyeliner 3 ARGANIA SPINOSA KERNEL OIL 03C - Eye Shadow 2 ARGANIA SPINOSA KERNEL OIL 03D - Eye Lotion 1 ARGANIA SPINOSA KERNEL OIL 03F - Mascara 2 ARGANIA SPINOSA KERNEL OIL 05A - Hair Conditioner 2 ARGANIA SPINOSA KERNEL OIL 05F - Shampoos (non-coloring) 1 ARGANIA SPINOSA KERNEL OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 2 ARGANIA SPINOSA KERNEL OIL 05I - Other Hair Preparations 3 ARGANIA SPINOSA KERNEL OIL 07A - Blushers (all types) 1 ARGANIA SPINOSA KERNEL OIL 07B - Face Powders 1 ARGANIA SPINOSA KERNEL OIL 07E - Lipstick 9 ARGANIA SPINOSA KERNEL OIL 07I - Other Makeup Preparations 1 ARGANIA SPINOSA KERNEL OIL 08E - Nail Polish and Enamel 1 ARGANIA SPINOSA KERNEL OIL 08G - Other Manicuring Preparations 1 ARGANIA SPINOSA KERNEL OIL 10A - Bath Soaps and Detergents 2 ARGANIA SPINOSA KERNEL OIL 10E - Other Personal Cleanliness Products 1 ARGANIA SPINOSA KERNEL OIL 11A - Aftershave Lotion 1 ARGANIA SPINOSA KERNEL OIL 11E - Shaving Cream 1 ARGANIA SPINOSA KERNEL OIL 11G - Other Shaving Preparation Products 1 ARGANIA SPINOSA KERNEL OIL 12A - Cleansing 2 ARGANIA SPINOSA KERNEL OIL 12C - Face and Neck (exc shave) 8 ARGANIA SPINOSA KERNEL OIL 12D - Body and Hand (exc shave) 12 ARGANIA SPINOSA KERNEL OIL 12F - Moisturizing 12 ARGANIA SPINOSA KERNEL OIL 12G - Night 3 ARGANIA SPINOSA KERNEL OIL 12H - Paste Masks (mud packs) 2 ARGANIA SPINOSA KERNEL OIL 12J - Other Skin Care Preps 3 ARGANIA SPINOSA KERNEL OIL 13A - Suntan Gels, Creams, and Liquids 3 ARGANIA SPINOSA KERNEL OIL 13B - Indoor Tanning Preparations 11 ARGANIA SPINOSA KERNEL OIL 13C - Other Suntan Preparations 6

ASTROCARYUM MURUMURU SEED BUTTER 03B - Eyeliner 3 ASTROCARYUM MURUMURU SEED BUTTER 03D - Eye Lotion 7 ASTROCARYUM MURUMURU SEED BUTTER 03G - Other Eye Makeup Preparations 11 ASTROCARYUM MURUMURU SEED BUTTER 05A - Hair Conditioner 4 ASTROCARYUM MURUMURU SEED BUTTER 05E - Rinses (non-coloring) 1 ASTROCARYUM MURUMURU SEED BUTTER 05F - Shampoos (non-coloring) 3 ASTROCARYUM MURUMURU SEED BUTTER 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 ASTROCARYUM MURUMURU SEED BUTTER 05I - Other Hair Preparations 2 ASTROCARYUM MURUMURU SEED BUTTER 06H - Other Hair Coloring Preparation 3 ASTROCARYUM MURUMURU SEED BUTTER 07B - Face Powders 5 ASTROCARYUM MURUMURU SEED BUTTER 07C - Foundations 23 ASTROCARYUM MURUMURU SEED BUTTER 07E - Lipstick 22 ASTROCARYUM MURUMURU SEED BUTTER 07I - Other Makeup Preparations 6 ASTROCARYUM MURUMURU SEED BUTTER 10A - Bath Soaps and Detergents 1 ASTROCARYUM MURUMURU SEED BUTTER 10E - Other Personal Cleanliness Products 2 ASTROCARYUM MURUMURU SEED BUTTER 11A - Aftershave Lotion 1 ASTROCARYUM MURUMURU SEED BUTTER 12A - Cleansing 4 ASTROCARYUM MURUMURU SEED BUTTER 12C - Face and Neck (exc shave) 5

CIR Panel Book Page 72 2010 FDA VCRP Raw Data

ASTROCARYUM MURUMURU SEED BUTTER 12D - Body and Hand (exc shave) 21 ASTROCARYUM MURUMURU SEED BUTTER 12F - Moisturizing 57 ASTROCARYUM MURUMURU SEED BUTTER 12G - Night 6 ASTROCARYUM MURUMURU SEED BUTTER 12H - Paste Masks (mud packs) 3 ASTROCARYUM MURUMURU SEED BUTTER 12J - Other Skin Care Preps 1

AVENA SATIVA (OAT) KERNEL OIL 01A - Baby Shampoos 2 AVENA SATIVA (OAT) KERNEL OIL 01B - Baby Lotions, Oils, Powders, and Creams 4 AVENA SATIVA (OAT) KERNEL OIL 02B - Bubble Baths 1 AVENA SATIVA (OAT) KERNEL OIL 07I - Other Makeup Preparations 1 AVENA SATIVA (OAT) KERNEL OIL 10A - Bath Soaps and Detergents 1 AVENA SATIVA (OAT) KERNEL OIL 10E - Other Personal Cleanliness Products 1 AVENA SATIVA (OAT) KERNEL OIL 12A - Cleansing 1 AVENA SATIVA (OAT) KERNEL OIL 12D - Body and Hand (exc shave) 3 AVENA SATIVA (OAT) KERNEL OIL 12F - Moisturizing 27 AVENA SATIVA (OAT) KERNEL OIL 12G - Night 1 AVENA SATIVA (OAT) KERNEL OIL 13C - Other Suntan Preparations 1

BORAGO OFFICINALIS SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 3 BORAGO OFFICINALIS SEED OIL 02A - Bath Oils, Tablets, and Salts 1 BORAGO OFFICINALIS SEED OIL 03C - Eye Shadow 2 BORAGO OFFICINALIS SEED OIL 03D - Eye Lotion 3 BORAGO OFFICINALIS SEED OIL 03F - Mascara 2 BORAGO OFFICINALIS SEED OIL 04E - Other Fragrance Preparation 1 BORAGO OFFICINALIS SEED OIL 05A - Hair Conditioner 3 BORAGO OFFICINALIS SEED OIL 05B - Hair Spray (aerosol fixatives) 2 BORAGO OFFICINALIS SEED OIL 05F - Shampoos (non-coloring) 2 BORAGO OFFICINALIS SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 3 BORAGO OFFICINALIS SEED OIL 07A - Blushers (all types) 2 BORAGO OFFICINALIS SEED OIL 07C - Foundations 1 BORAGO OFFICINALIS SEED OIL 07E - Lipstick 1 BORAGO OFFICINALIS SEED OIL 07I - Other Makeup Preparations 1 BORAGO OFFICINALIS SEED OIL 10A - Bath Soaps and Detergents 2 BORAGO OFFICINALIS SEED OIL 10E - Other Personal Cleanliness Products 2 BORAGO OFFICINALIS SEED OIL 12A - Cleansing 7 BORAGO OFFICINALIS SEED OIL 12C - Face and Neck (exc shave) 30 BORAGO OFFICINALIS SEED OIL 12D - Body and Hand (exc shave) 23 BORAGO OFFICINALIS SEED OIL 12F - Moisturizing 54 BORAGO OFFICINALIS SEED OIL 12G - Night 8 BORAGO OFFICINALIS SEED OIL 12H - Paste Masks (mud packs) 3 BORAGO OFFICINALIS SEED OIL 12J - Other Skin Care Preps 17 BORAGO OFFICINALIS SEED OIL 13B - Indoor Tanning Preparations 7

CAMELINA SATIVA SEED OIL 05A - Hair Conditioner 8 CAMELINA SATIVA SEED OIL 05F - Shampoos (non-coloring) 7 CAMELINA SATIVA SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 CAMELINA SATIVA SEED OIL 05I - Other Hair Preparations 13 CAMELINA SATIVA SEED OIL 07E - Lipstick 34 CAMELINA SATIVA SEED OIL 12C - Face and Neck (exc shave) 3 CAMELINA SATIVA SEED OIL 12D - Body and Hand (exc shave) 4 CAMELINA SATIVA SEED OIL 12F - Moisturizing 6

CAMELLIA OLEIFERA SEED OIL 05F - Shampoos (non-coloring) 1 CAMELLIA OLEIFERA SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 CAMELLIA OLEIFERA SEED OIL 07E - Lipstick 3 CAMELLIA OLEIFERA SEED OIL 12A - Cleansing 1 CAMELLIA OLEIFERA SEED OIL 12C - Face and Neck (exc shave) 2 CAMELLIA OLEIFERA SEED OIL 12D - Body and Hand (exc shave) 7 CAMELLIA OLEIFERA SEED OIL 12F - Moisturizing 8 CAMELLIA OLEIFERA SEED OIL 12G - Night 2

CIR Panel Book Page 73 2010 FDA VCRP Raw Data

HYDROGENATED CAMELLIA OLEIFERA SEED OIL 12F - Moisturizing 1

CAMELLIA SINENSIS SEED OIL 05A - Hair Conditioner 1 CAMELLIA SINENSIS SEED OIL 05F - Shampoos (non-coloring) 1 CAMELLIA SINENSIS SEED OIL 07B - Face Powders 1 CAMELLIA SINENSIS SEED OIL 07E - Lipstick 1 CAMELLIA SINENSIS SEED OIL 07I - Other Makeup Preparations 2 CAMELLIA SINENSIS SEED OIL 10A - Bath Soaps and Detergents 2 CAMELLIA SINENSIS SEED OIL 12F - Moisturizing 4

CARYOCAR BRASILIENSE FRUIT OIL 03D - Eye Lotion 12 CARYOCAR BRASILIENSE FRUIT OIL 05A - Hair Conditioner 1 CARYOCAR BRASILIENSE FRUIT OIL 07E - Lipstick 12 CARYOCAR BRASILIENSE FRUIT OIL 12C - Face and Neck (exc shave) 2 CARYOCAR BRASILIENSE FRUIT OIL 12D - Body and Hand (exc shave) 2 CARYOCAR BRASILIENSE FRUIT OIL 12F - Moisturizing 1 CARYOCAR BRASILIENSE FRUIT OIL 12H - Paste Masks (mud packs) 1

QUINOA OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1

CITRULLUS LANATUS (WATERMELON) SEED OIL 07A - Blushers (all types) 1

CITRULLUS VULGARIS (WATERMELON) SEED OIL 07I - Other Makeup Preparations 1

CITRUS PARADISI (GRAPEFRUIT) SEED OIL 10A - Bath Soaps and Detergents 1 CITRUS PARADISI (GRAPEFRUIT) SEED OIL 12C - Face and Neck (exc shave) 1 CITRUS PARADISI (GRAPEFRUIT) SEED OIL 12D - Body and Hand (exc shave) 1 CITRUS PARADISI (GRAPEFRUIT) SEED OIL 12F - Moisturizing 3

CITRUS MEDICA LIMONUM (LEMON) SEED OIL 10A - Bath Soaps and Detergents 1 CITRUS MEDICA LIMONUM (LEMON) SEED OIL 12F - Moisturizing 1 CITRUS MEDICA LIMONUM (LEMON) SEED OIL 12H - Paste Masks (mud packs) 1 CITRUS MEDICA LIMONUM (LEMON) SEED OIL 12J - Other Skin Care Preps 2

CUCUMIS SATIVUS (CUCUMBER) OIL 03D - Eye Lotion 1 CUCUMIS SATIVUS (CUCUMBER) OIL 05F - Shampoos (non-coloring) 1 CUCUMIS SATIVUS (CUCUMBER) OIL 12C - Face and Neck (exc shave) 1 CUCUMIS SATIVUS (CUCUMBER) OIL 12F - Moisturizing 1 CUCUMIS SATIVUS (CUCUMBER) OIL 12J - Other Skin Care Preps 2

CUCURBITA PEPO (PUMPKIN) SEED OIL 03D - Eye Lotion 1 CUCURBITA PEPO (PUMPKIN) SEED OIL 04C - Powders (dusting and talcum, excluding aftershave talc) 1 CUCURBITA PEPO (PUMPKIN) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 CUCURBITA PEPO (PUMPKIN) SEED OIL 12A - Cleansing 1 CUCURBITA PEPO (PUMPKIN) SEED OIL 12C - Face and Neck (exc shave) 4 CUCURBITA PEPO (PUMPKIN) SEED OIL 12D - Body and Hand (exc shave) 3 CUCURBITA PEPO (PUMPKIN) SEED OIL 12F - Moisturizing 5 CUCURBITA PEPO (PUMPKIN) SEED OIL 12G - Night 1 CUCURBITA PEPO (PUMPKIN) SEED OIL 13A - Suntan Gels, Creams, and Liquids 1

EUTERPE OLERACEA FRUIT OIL 03C - Eye Shadow 1 EUTERPE OLERACEA FRUIT OIL 03D - Eye Lotion 1 EUTERPE OLERACEA FRUIT OIL 05A - Hair Conditioner 2 EUTERPE OLERACEA FRUIT OIL 05B - Hair Spray (aerosol fixatives) 1 EUTERPE OLERACEA FRUIT OIL 05F - Shampoos (non-coloring) 4

CIR Panel Book Page 74 2010 FDA VCRP Raw Data

EUTERPE OLERACEA FRUIT OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 5 EUTERPE OLERACEA FRUIT OIL 05I - Other Hair Preparations 3 EUTERPE OLERACEA FRUIT OIL 07E - Lipstick 1 EUTERPE OLERACEA FRUIT OIL 10A - Bath Soaps and Detergents 2 EUTERPE OLERACEA FRUIT OIL 10E - Other Personal Cleanliness Products 1 EUTERPE OLERACEA FRUIT OIL 12A - Cleansing 1 EUTERPE OLERACEA FRUIT OIL 12C - Face and Neck (exc shave) 2 EUTERPE OLERACEA FRUIT OIL 12F - Moisturizing 3 EUTERPE OLERACEA FRUIT OIL 12G - Night 2

IRVINGIA GABONENSIS KERNEL BUTTER 03D - Eye Lotion 2 IRVINGIA GABONENSIS KERNEL BUTTER 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 IRVINGIA GABONENSIS KERNEL BUTTER 07E - Lipstick 64 IRVINGIA GABONENSIS KERNEL BUTTER 07I - Other Makeup Preparations 1 IRVINGIA GABONENSIS KERNEL BUTTER 12C - Face and Neck (exc shave) 11 IRVINGIA GABONENSIS KERNEL BUTTER 12D - Body and Hand (exc shave) 8 IRVINGIA GABONENSIS KERNEL BUTTER 12F - Moisturizing 15 IRVINGIA GABONENSIS KERNEL BUTTER 12G - Night 1 IRVINGIA GABONENSIS KERNEL BUTTER 12J - Other Skin Care Preps 1 IRVINGIA GABONENSIS KERNEL BUTTER 13A - Suntan Gels, Creams, and Liquids 2 IRVINGIA GABONENSIS KERNEL BUTTER 13B - Indoor Tanning Preparations 3

LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 1 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 02A - Bath Oils, Tablets, and Salts 2 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 03B - Eyeliner 13 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 03D - Eye Lotion 4 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 03F - Mascara 12 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 03G - Other Eye Makeup Preparations 1 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 05A - Hair Conditioner 17 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 05F - Shampoos (non-coloring) 7 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 17 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 05I - Other Hair Preparations 6 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests) 43 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 06D - Hair Shampoos (coloring) 2 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 06H - Other Hair Coloring Preparation 1 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 07C - Foundations 6 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 07E - Lipstick 67 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 07I - Other Makeup Preparations 7 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 10A - Bath Soaps and Detergents 3 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 10E - Other Personal Cleanliness Products 1 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 11E - Shaving Cream 2 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 11G - Other Shaving Preparation Products 1 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12A - Cleansing 9 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12C - Face and Neck (exc shave) 24 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12D - Body and Hand (exc shave) 18 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12E - Foot Powders and Sprays 1 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12F - Moisturizing 28 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12G - Night 9 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12H - Paste Masks (mud packs) 3 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12I - Skin Fresheners 1 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 12J - Other Skin Care Preps 9 LIMNANTHES ALBA (MEADOWFOAM) SEED OIL 13B - Indoor Tanning Preparations 1

LINUM USITATISSIMUM (LINSEED) SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 2 LINUM USITATISSIMUM (LINSEED) SEED OIL 02A - Bath Oils, Tablets, and Salts 1 LINUM USITATISSIMUM (LINSEED) SEED OIL 02D - Other Bath Preparations 1 LINUM USITATISSIMUM (LINSEED) SEED OIL 03D - Eye Lotion 2 LINUM USITATISSIMUM (LINSEED) SEED OIL 03G - Other Eye Makeup Preparations 1 LINUM USITATISSIMUM (LINSEED) SEED OIL 05A - Hair Conditioner 13 LINUM USITATISSIMUM (LINSEED) SEED OIL 05B - Hair Spray (aerosol fixatives) 3 LINUM USITATISSIMUM (LINSEED) SEED OIL 05F - Shampoos (non-coloring) 10 LINUM USITATISSIMUM (LINSEED) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 14

CIR Panel Book Page 75 2010 FDA VCRP Raw Data

LINUM USITATISSIMUM (LINSEED) SEED OIL 05I - Other Hair Preparations 2 LINUM USITATISSIMUM (LINSEED) SEED OIL 07I - Other Makeup Preparations 1 LINUM USITATISSIMUM (LINSEED) SEED OIL 08E - Nail Polish and Enamel 2 LINUM USITATISSIMUM (LINSEED) SEED OIL 10A - Bath Soaps and Detergents 4 LINUM USITATISSIMUM (LINSEED) SEED OIL 10E - Other Personal Cleanliness Products 1 LINUM USITATISSIMUM (LINSEED) SEED OIL 11E - Shaving Cream 2 LINUM USITATISSIMUM (LINSEED) SEED OIL 12A - Cleansing 18 LINUM USITATISSIMUM (LINSEED) SEED OIL 12C - Face and Neck (exc shave) 7 LINUM USITATISSIMUM (LINSEED) SEED OIL 12D - Body and Hand (exc shave) 5 LINUM USITATISSIMUM (LINSEED) SEED OIL 12F - Moisturizing 8 LINUM USITATISSIMUM (LINSEED) SEED OIL 12G - Night 2 LINUM USITATISSIMUM (LINSEED) SEED OIL 12I - Skin Fresheners 1 LINUM USITATISSIMUM (LINSEED) SEED OIL 12J - Other Skin Care Preps 2

LINSEED ACID 01B - Baby Lotions, Oils, Powders, and Creams 1 LINSEED ACID 12D - Body and Hand (exc shave) 1 LINSEED ACID 12J - Other Skin Care Preps 1

MANGIFERA INDICA (MANGO) SEED OIL 03B - Eyeliner 13 MANGIFERA INDICA (MANGO) SEED OIL 04E - Other Fragrance Preparation 1 MANGIFERA INDICA (MANGO) SEED OIL 05A - Hair Conditioner 2 MANGIFERA INDICA (MANGO) SEED OIL 05F - Shampoos (non-coloring) 3 MANGIFERA INDICA (MANGO) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 MANGIFERA INDICA (MANGO) SEED OIL 05I - Other Hair Preparations 6 MANGIFERA INDICA (MANGO) SEED OIL 07E - Lipstick 7 MANGIFERA INDICA (MANGO) SEED OIL 07I - Other Makeup Preparations 7 MANGIFERA INDICA (MANGO) SEED OIL 10E - Other Personal Cleanliness Products 2 MANGIFERA INDICA (MANGO) SEED OIL 12C - Face and Neck (exc shave) 8 MANGIFERA INDICA (MANGO) SEED OIL 12D - Body and Hand (exc shave) 7 MANGIFERA INDICA (MANGO) SEED OIL 12F - Moisturizing 9 MANGIFERA INDICA (MANGO) SEED OIL 12G - Night 1 MANGIFERA INDICA (MANGO) SEED OIL 12H - Paste Masks (mud packs) 1 MANGIFERA INDICA (MANGO) SEED OIL 12J - Other Skin Care Preps 4

MANGIFERA INDICA (MANGO) SEED BUTTER 01B - Baby Lotions, Oils, Powders, and Creams 3 MANGIFERA INDICA (MANGO) SEED BUTTER 02B - Bubble Baths 1 MANGIFERA INDICA (MANGO) SEED BUTTER 02D - Other Bath Preparations 3 MANGIFERA INDICA (MANGO) SEED BUTTER 03C - Eye Shadow 4 MANGIFERA INDICA (MANGO) SEED BUTTER 03D - Eye Lotion 2 MANGIFERA INDICA (MANGO) SEED BUTTER 04B - Perfumes 2 MANGIFERA INDICA (MANGO) SEED BUTTER 05A - Hair Conditioner 2 MANGIFERA INDICA (MANGO) SEED BUTTER 05F - Shampoos (non-coloring) 3 MANGIFERA INDICA (MANGO) SEED BUTTER 05G - Tonics, Dressings, and Other Hair Grooming Aids 4 MANGIFERA INDICA (MANGO) SEED BUTTER 05I - Other Hair Preparations 3 MANGIFERA INDICA (MANGO) SEED BUTTER 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests) 13 MANGIFERA INDICA (MANGO) SEED BUTTER 06H - Other Hair Coloring Preparation 3 MANGIFERA INDICA (MANGO) SEED BUTTER 07A - Blushers (all types) 3 MANGIFERA INDICA (MANGO) SEED BUTTER 07B - Face Powders 5 MANGIFERA INDICA (MANGO) SEED BUTTER 07C - Foundations 1 MANGIFERA INDICA (MANGO) SEED BUTTER 07E - Lipstick 25 MANGIFERA INDICA (MANGO) SEED BUTTER 07H - Makeup Fixatives 3 MANGIFERA INDICA (MANGO) SEED BUTTER 07I - Other Makeup Preparations 7 MANGIFERA INDICA (MANGO) SEED BUTTER 10A - Bath Soaps and Detergents 5 MANGIFERA INDICA (MANGO) SEED BUTTER 10E - Other Personal Cleanliness Products 5 MANGIFERA INDICA (MANGO) SEED BUTTER 12A - Cleansing 3 MANGIFERA INDICA (MANGO) SEED BUTTER 12C - Face and Neck (exc shave) 4 MANGIFERA INDICA (MANGO) SEED BUTTER 12D - Body and Hand (exc shave) 15 MANGIFERA INDICA (MANGO) SEED BUTTER 12F - Moisturizing 39 MANGIFERA INDICA (MANGO) SEED BUTTER 12G - Night 2 MANGIFERA INDICA (MANGO) SEED BUTTER 12H - Paste Masks (mud packs) 3 MANGIFERA INDICA (MANGO) SEED BUTTER 12J - Other Skin Care Preps 10 MANGIFERA INDICA (MANGO) SEED BUTTER 13B - Indoor Tanning Preparations 2

CIR Panel Book Page 76 2010 FDA VCRP Raw Data

SODIUM MANGOSEEDATE 10A - Bath Soaps and Detergents 1

#REF! 03F - Mascara 4 MORINGA PTERYGOSPERMA SEED OIL 07E - Lipstick 1 MORINGA PTERYGOSPERMA SEED OIL 07I - Other Makeup Preparations 1 MORINGA PTERYGOSPERMA SEED OIL 12A - Cleansing 2 MORINGA PTERYGOSPERMA SEED OIL 12C - Face and Neck (exc shave) 2 MORINGA PTERYGOSPERMA SEED OIL 12D - Body and Hand (exc shave) 2 MORINGA PTERYGOSPERMA SEED OIL 12F - Moisturizing 2 MORINGA PTERYGOSPERMA SEED OIL 12J - Other Skin Care Preps 1

OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 01B - Baby Lotions, Oils, Powders, and Creams 3 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 02A - Bath Oils, Tablets, and Salts 1 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 02B - Bubble Baths 1 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 03D - Eye Lotion 4 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 05A - Hair Conditioner 16 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 05B - Hair Spray (aerosol fixatives) 2 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 05F - Shampoos (non-coloring) 5 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 6 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 05I - Other Hair Preparations 8 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 07A - Blushers (all types) 1 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 07C - Foundations 2 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 07E - Lipstick 14 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 07I - Other Makeup Preparations 2 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 08B - Cuticle Softeners 1 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 08E - Nail Polish and Enamel 2 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 08G - Other Manicuring Preparations 1 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 10A - Bath Soaps and Detergents 4 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 11E - Shaving Cream 1 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 12A - Cleansing 6 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 12C - Face and Neck (exc shave) 10 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 12D - Body and Hand (exc shave) 15 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 12F - Moisturizing 24 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 12G - Night 8 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 12H - Paste Masks (mud packs) 3 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 12J - Other Skin Care Preps 9 OENOTHERA BIENNIS (EVENING PRIMROSE) OIL 13B - Indoor Tanning Preparations 1

HYDROGENATED EVENING PRIMROSE OIL 03B - Eyeliner 1 HYDROGENATED EVENING PRIMROSE OIL 12C - Face and Neck (exc shave) 2 HYDROGENATED EVENING PRIMROSE OIL 12D - Body and Hand (exc shave) 5 HYDROGENATED EVENING PRIMROSE OIL 12F - Moisturizing 6

ORBIGNYA COHUNE SEED OIL 05A - Hair Conditioner 1

ORBIGNYA OLEIFERA SEED OIL 02D - Other Bath Preparations 2 ORBIGNYA OLEIFERA SEED OIL 03C - Eye Shadow 1 ORBIGNYA OLEIFERA SEED OIL 03D - Eye Lotion 1 ORBIGNYA OLEIFERA SEED OIL 03G - Other Eye Makeup Preparations 5 ORBIGNYA OLEIFERA SEED OIL 05A - Hair Conditioner 16 ORBIGNYA OLEIFERA SEED OIL 05B - Hair Spray (aerosol fixatives) 5 ORBIGNYA OLEIFERA SEED OIL 05F - Shampoos (non-coloring) 7 ORBIGNYA OLEIFERA SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 10 ORBIGNYA OLEIFERA SEED OIL 05I - Other Hair Preparations 5 ORBIGNYA OLEIFERA SEED OIL 06C - Hair Rinses (coloring) 5 ORBIGNYA OLEIFERA SEED OIL 06H - Other Hair Coloring Preparation 3 ORBIGNYA OLEIFERA SEED OIL 07E - Lipstick 57 ORBIGNYA OLEIFERA SEED OIL 07I - Other Makeup Preparations 4

CIR Panel Book Page 77 2010 FDA VCRP Raw Data

ORBIGNYA OLEIFERA SEED OIL 10A - Bath Soaps and Detergents 3 ORBIGNYA OLEIFERA SEED OIL 10E - Other Personal Cleanliness Products 2 ORBIGNYA OLEIFERA SEED OIL 11G - Other Shaving Preparation Products 1 ORBIGNYA OLEIFERA SEED OIL 12A - Cleansing 4 ORBIGNYA OLEIFERA SEED OIL 12C - Face and Neck (exc shave) 3 ORBIGNYA OLEIFERA SEED OIL 12D - Body and Hand (exc shave) 9 ORBIGNYA OLEIFERA SEED OIL 12F - Moisturizing 12 ORBIGNYA OLEIFERA SEED OIL 12G - Night 3 ORBIGNYA OLEIFERA SEED OIL 12J - Other Skin Care Preps 3

PERILLA OCYMOIDES SEED OIL 03D - Eye Lotion 2 PERILLA OCYMOIDES SEED OIL 05A - Hair Conditioner 2 PERILLA OCYMOIDES SEED OIL 07I - Other Makeup Preparations 1 PERILLA OCYMOIDES SEED OIL 12D - Body and Hand (exc shave) 2

HYDROGENATED AVOCADO OIL 05A - Hair Conditioner 1 HYDROGENATED AVOCADO OIL 05F - Shampoos (non-coloring) 1 HYDROGENATED AVOCADO OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 HYDROGENATED AVOCADO OIL 07E - Lipstick 2 HYDROGENATED AVOCADO OIL 12F - Moisturizing 6

PERSEA GRATISSIMA (AVOCADO) BUTTER 07E - Lipstick 11 PERSEA GRATISSIMA (AVOCADO) BUTTER 12F - Moisturizing 4

PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 01B - Baby Lotions, Oils, Powders, and Creams 1 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 02D - Other Bath Preparations 4 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 03B - Eyeliner 1 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 03C - Eye Shadow 4 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 03D - Eye Lotion 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 03G - Other Eye Makeup Preparations 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 04E - Other Fragrance Preparation 4 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 05G - Tonics, Dressings, and Other Hair Grooming Aids 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 07E - Lipstick 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 07I - Other Makeup Preparations 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 08C - Nail Creams and Lotions 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 08G - Other Manicuring Preparations 1 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 12A - Cleansing 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 12C - Face and Neck (exc shave) 4 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 12D - Body and Hand (exc shave) 6 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 12F - Moisturizing 16 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 12G - Night 2 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 12J - Other Skin Care Preps 5 PERSEA GRATISSIMA (AVOCADO) OIL UNSAPONIFIABLES 13C - Other Suntan Preparations 1

SODIUM AVOCADOATE 10A - Bath Soaps and Detergents 1

PLUKENETIA VOLUBILIS SEED OIL 03G - Other Eye Makeup Preparations 1 PLUKENETIA VOLUBILIS SEED OIL 07E - Lipstick 3 PLUKENETIA VOLUBILIS SEED OIL 12C - Face and Neck (exc shave) 4 PLUKENETIA VOLUBILIS SEED OIL 12F - Moisturizing 2 PLUKENETIA VOLUBILIS SEED OIL 12G - Night 2 PLUKENETIA VOLUBILIS SEED OIL 12H - Paste Masks (mud packs) 1

PRUNUS ARMENIACA (APRICOT) KERNEL OIL 01B - Baby Lotions, Oils, Powders, and Creams 5 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 01C - Other Baby Products 2 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 02A - Bath Oils, Tablets, and Salts 5 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 02D - Other Bath Preparations 3 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 03A - Eyebrow Pencil 1

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PRUNUS ARMENIACA (APRICOT) KERNEL OIL 03B - Eyeliner 1 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 03D - Eye Lotion 8 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 03E - Eye Makeup Remover 2 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 03F - Mascara 4 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 03G - Other Eye Makeup Preparations 9 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 04E - Other Fragrance Preparation 5 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 05A - Hair Conditioner 33 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 05E - Rinses (non-coloring) 1 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 05F - Shampoos (non-coloring) 22 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 3 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 05I - Other Hair Preparations 19 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests) 5 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 06D - Hair Shampoos (coloring) 3 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 06G - Hair Bleaches 2 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 07B - Face Powders 1 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 07C - Foundations 4 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 07E - Lipstick 38 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 07I - Other Makeup Preparations 10 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 08A - Basecoats and Undercoats 1 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 08B - Cuticle Softeners 4 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 08C - Nail Creams and Lotions 2 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 08E - Nail Polish and Enamel 1 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 08G - Other Manicuring Preparations 2 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 10A - Bath Soaps and Detergents 11 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 10B - Deodorants (underarm) 1 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 10E - Other Personal Cleanliness Products 12 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 11A - Aftershave Lotion 2 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 11E - Shaving Cream 1 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 11G - Other Shaving Preparation Products 3 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12A - Cleansing 31 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12B - Depilatories 2 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12C - Face and Neck (exc shave) 47 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12D - Body and Hand (exc shave) 87 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12F - Moisturizing 124 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12G - Night 13 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12H - Paste Masks (mud packs) 3 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12I - Skin Fresheners 4 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 12J - Other Skin Care Preps 46 PRUNUS ARMENIACA (APRICOT) KERNEL OIL 13B - Indoor Tanning Preparations 5

HYDROGENATED APRICOT KERNEL OIL 12D - Body and Hand (exc shave) 1 HYDROGENATED APRICOT KERNEL OIL 12F - Moisturizing 1

PRUNUS AVIUM (SWEET CHERRY) SEED OIL 10A - Bath Soaps and Detergents 2

PRUNUS PERSICA (PEACH) KERNEL OIL 02A - Bath Oils, Tablets, and Salts 1 PRUNUS PERSICA (PEACH) KERNEL OIL 05F - Shampoos (non-coloring) 2 PRUNUS PERSICA (PEACH) KERNEL OIL 05I - Other Hair Preparations 2 PRUNUS PERSICA (PEACH) KERNEL OIL 07I - Other Makeup Preparations 1 PRUNUS PERSICA (PEACH) KERNEL OIL 10E - Other Personal Cleanliness Products 1 PRUNUS PERSICA (PEACH) KERNEL OIL 12A - Cleansing 2 PRUNUS PERSICA (PEACH) KERNEL OIL 12C - Face and Neck (exc shave) 1 PRUNUS PERSICA (PEACH) KERNEL OIL 12D - Body and Hand (exc shave) 4 PRUNUS PERSICA (PEACH) KERNEL OIL 12F - Moisturizing 2 PRUNUS PERSICA (PEACH) KERNEL OIL 12J - Other Skin Care Preps 6

PYRUS MALUS (APPLE ) SEED OIL 07E - Lipstick 7 PYRUS MALUS (APPLE ) SEED OIL 12F - Moisturizing 1

RIBES NIGRUM (BLACK CURRANT) SEED OIL 03G - Other Eye Makeup Preparations 2

CIR Panel Book Page 79 2010 FDA VCRP Raw Data

RIBES NIGRUM (BLACK CURRANT) SEED OIL 05A - Hair Conditioner 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 05F - Shampoos (non-coloring) 2 RIBES NIGRUM (BLACK CURRANT) SEED OIL 05I - Other Hair Preparations 2 RIBES NIGRUM (BLACK CURRANT) SEED OIL 07C - Foundations 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 07E - Lipstick 7 RIBES NIGRUM (BLACK CURRANT) SEED OIL 07I - Other Makeup Preparations 2 RIBES NIGRUM (BLACK CURRANT) SEED OIL 08A - Basecoats and Undercoats 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 08B - Cuticle Softeners 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 08E - Nail Polish and Enamel 2 RIBES NIGRUM (BLACK CURRANT) SEED OIL 08G - Other Manicuring Preparations 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 10A - Bath Soaps and Detergents 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 10E - Other Personal Cleanliness Products 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 12A - Cleansing 2 RIBES NIGRUM (BLACK CURRANT) SEED OIL 12C - Face and Neck (exc shave) 7 RIBES NIGRUM (BLACK CURRANT) SEED OIL 12D - Body and Hand (exc shave) 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 12F - Moisturizing 14 RIBES NIGRUM (BLACK CURRANT) SEED OIL 12G - Night 2 RIBES NIGRUM (BLACK CURRANT) SEED OIL 12H - Paste Masks (mud packs) 1 RIBES NIGRUM (BLACK CURRANT) SEED OIL 12J - Other Skin Care Preps 2

RUBUS IDAEUS (RASPBERRY) SEED OIL 02D - Other Bath Preparations 1 RUBUS IDAEUS (RASPBERRY) SEED OIL 07E - Lipstick 1 RUBUS IDAEUS (RASPBERRY) SEED OIL 07I - Other Makeup Preparations 2 RUBUS IDAEUS (RASPBERRY) SEED OIL 12A - Cleansing 1 RUBUS IDAEUS (RASPBERRY) SEED OIL 12C - Face and Neck (exc shave) 2 RUBUS IDAEUS (RASPBERRY) SEED OIL 12F - Moisturizing 1 RUBUS IDAEUS (RASPBERRY) SEED OIL 12G - Night 2

SCLEROCARYA BIRREA SEED OIL 04E - Other Fragrance Preparation 2 SCLEROCARYA BIRREA SEED OIL 05A - Hair Conditioner 2 SCLEROCARYA BIRREA SEED OIL 05F - Shampoos (non-coloring) 1 SCLEROCARYA BIRREA SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 3 SCLEROCARYA BIRREA SEED OIL 07E - Lipstick 6 SCLEROCARYA BIRREA SEED OIL 10E - Other Personal Cleanliness Products 2 SCLEROCARYA BIRREA SEED OIL 12A - Cleansing 1 SCLEROCARYA BIRREA SEED OIL 12C - Face and Neck (exc shave) 1 SCLEROCARYA BIRREA SEED OIL 12D - Body and Hand (exc shave) 3 SCLEROCARYA BIRREA SEED OIL 12F - Moisturizing 5 SCLEROCARYA BIRREA SEED OIL 12G - Night 2 SCLEROCARYA BIRREA SEED OIL 12J - Other Skin Care Preps 1

SOLANUM LYCOPERSICUM (TOMATO) SEED OIL 12C - Face and Neck (exc shave) 1

THEOBROMA CACAO (COCOA) SEED BUTTER 01B - Baby Lotions, Oils, Powders, and Creams 8 THEOBROMA CACAO (COCOA) SEED BUTTER 01C - Other Baby Products 4 THEOBROMA CACAO (COCOA) SEED BUTTER 02D - Other Bath Preparations 2 THEOBROMA CACAO (COCOA) SEED BUTTER 03A - Eyebrow Pencil 1 THEOBROMA CACAO (COCOA) SEED BUTTER 03B - Eyeliner 3 THEOBROMA CACAO (COCOA) SEED BUTTER 03D - Eye Lotion 5 THEOBROMA CACAO (COCOA) SEED BUTTER 03E - Eye Makeup Remover 1 THEOBROMA CACAO (COCOA) SEED BUTTER 03G - Other Eye Makeup Preparations 1 THEOBROMA CACAO (COCOA) SEED BUTTER 05A - Hair Conditioner 10 THEOBROMA CACAO (COCOA) SEED BUTTER 05C - Hair Straighteners 7 THEOBROMA CACAO (COCOA) SEED BUTTER 05F - Shampoos (non-coloring) 2 THEOBROMA CACAO (COCOA) SEED BUTTER 05G - Tonics, Dressings, and Other Hair Grooming Aids 2 THEOBROMA CACAO (COCOA) SEED BUTTER 05I - Other Hair Preparations 3 THEOBROMA CACAO (COCOA) SEED BUTTER 07A - Blushers (all types) 2 THEOBROMA CACAO (COCOA) SEED BUTTER 07E - Lipstick 33 THEOBROMA CACAO (COCOA) SEED BUTTER 07F - Makeup Bases 5 THEOBROMA CACAO (COCOA) SEED BUTTER 07G - Rouges 1 THEOBROMA CACAO (COCOA) SEED BUTTER 07I - Other Makeup Preparations 10

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THEOBROMA CACAO (COCOA) SEED BUTTER 08B - Cuticle Softeners 1 THEOBROMA CACAO (COCOA) SEED BUTTER 10A - Bath Soaps and Detergents 26 THEOBROMA CACAO (COCOA) SEED BUTTER 10E - Other Personal Cleanliness Products 9 THEOBROMA CACAO (COCOA) SEED BUTTER 11A - Aftershave Lotion 1 THEOBROMA CACAO (COCOA) SEED BUTTER 11B - Beard Softeners 1 THEOBROMA CACAO (COCOA) SEED BUTTER 11E - Shaving Cream 2 THEOBROMA CACAO (COCOA) SEED BUTTER 11G - Other Shaving Preparation Products 5 THEOBROMA CACAO (COCOA) SEED BUTTER 12A - Cleansing 4 THEOBROMA CACAO (COCOA) SEED BUTTER 12B - Depilatories 2 THEOBROMA CACAO (COCOA) SEED BUTTER 12C - Face and Neck (exc shave) 13 THEOBROMA CACAO (COCOA) SEED BUTTER 12D - Body and Hand (exc shave) 72 THEOBROMA CACAO (COCOA) SEED BUTTER 12E - Foot Powders and Sprays 2 THEOBROMA CACAO (COCOA) SEED BUTTER 12F - Moisturizing 147 THEOBROMA CACAO (COCOA) SEED BUTTER 12G - Night 7 THEOBROMA CACAO (COCOA) SEED BUTTER 12H - Paste Masks (mud packs) 5 THEOBROMA CACAO (COCOA) SEED BUTTER 12I - Skin Fresheners 4 THEOBROMA CACAO (COCOA) SEED BUTTER 12J - Other Skin Care Preps 26 THEOBROMA CACAO (COCOA) SEED BUTTER 13A - Suntan Gels, Creams, and Liquids 7 THEOBROMA CACAO (COCOA) SEED BUTTER 13B - Indoor Tanning Preparations 8

THEOBROMA GRANDIFLORUM SEED BUTTER 02B - Bubble Baths 4 THEOBROMA GRANDIFLORUM SEED BUTTER 02D - Other Bath Preparations 1 THEOBROMA GRANDIFLORUM SEED BUTTER 03A - Eyebrow Pencil 1 THEOBROMA GRANDIFLORUM SEED BUTTER 03B - Eyeliner 13 THEOBROMA GRANDIFLORUM SEED BUTTER 03D - Eye Lotion 1 THEOBROMA GRANDIFLORUM SEED BUTTER 03G - Other Eye Makeup Preparations 6 THEOBROMA GRANDIFLORUM SEED BUTTER 05A - Hair Conditioner 3 THEOBROMA GRANDIFLORUM SEED BUTTER 05F - Shampoos (non-coloring) 2 THEOBROMA GRANDIFLORUM SEED BUTTER 05G - Tonics, Dressings, and Other Hair Grooming Aids 2 THEOBROMA GRANDIFLORUM SEED BUTTER 05I - Other Hair Preparations 2 THEOBROMA GRANDIFLORUM SEED BUTTER 06H - Other Hair Coloring Preparation 3 THEOBROMA GRANDIFLORUM SEED BUTTER 07E - Lipstick 49 THEOBROMA GRANDIFLORUM SEED BUTTER 07I - Other Makeup Preparations 4 THEOBROMA GRANDIFLORUM SEED BUTTER 10A - Bath Soaps and Detergents 7 THEOBROMA GRANDIFLORUM SEED BUTTER 10E - Other Personal Cleanliness Products 12 THEOBROMA GRANDIFLORUM SEED BUTTER 11E - Shaving Cream 1 THEOBROMA GRANDIFLORUM SEED BUTTER 12A - Cleansing 1 THEOBROMA GRANDIFLORUM SEED BUTTER 12C - Face and Neck (exc shave) 6 THEOBROMA GRANDIFLORUM SEED BUTTER 12D - Body and Hand (exc shave) 6 THEOBROMA GRANDIFLORUM SEED BUTTER 12F - Moisturizing 25 THEOBROMA GRANDIFLORUM SEED BUTTER 12G - Night 1 THEOBROMA GRANDIFLORUM SEED BUTTER 12J - Other Skin Care Preps 2 THEOBROMA GRANDIFLORUM SEED BUTTER 13C - Other Suntan Preparations 1

TRITICUM VULGARE (WHEAT) GERM OIL UNSAPONIFIABLES03D - Eye Lotion 1 TRITICUM VULGARE (WHEAT) GERM OIL UNSAPONIFIABLES12C - Face and Neck (exc shave) 11 TRITICUM VULGARE (WHEAT) GERM OIL UNSAPONIFIABLES12D - Body and Hand (exc shave) 1 TRITICUM VULGARE (WHEAT) GERM OIL UNSAPONIFIABLES12F - Moisturizing 2 TRITICUM VULGARE (WHEAT) GERM OIL UNSAPONIFIABLES12G - Night 1 TRITICUM VULGARE (WHEAT) GERM OIL UNSAPONIFIABLES13C - Other Suntan Preparations 1

WHEAT GERM ACID 05A - Hair Conditioner 13 WHEAT GERM ACID 05G - Tonics, Dressings, and Other Hair Grooming Aids 2 WHEAT GERM ACID 05I - Other Hair Preparations 1

VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 03D - Eye Lotion 2 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 05A - Hair Conditioner 1 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 05I - Other Hair Preparations 3 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 10E - Other Personal Cleanliness Products 1 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 12C - Face and Neck (exc shave) 2 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 12D - Body and Hand (exc shave) 2

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VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 12F - Moisturizing 3 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 12G - Night 3 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 12H - Paste Masks (mud packs) 1 VACCINIUM MACROCARPON (CRANBERRY) SEED OIL 12J - Other Skin Care Preps 3

VACCINIUM OXYCOCCOS (CRANBERRY) SEED OIL 12F - Moisturizing 1 VACCINIUM OXYCOCCOS SEED OIL 12A - Cleansing 1 VACCINIUM OXYCOCCOS SEED OIL 12D - Body and Hand (exc shave) 1 VACCINIUM OXYCOCCOS SEED OIL 12F - Moisturizing 1

VITIS VINIFERA (GRAPE) SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 4 VITIS VINIFERA (GRAPE) SEED OIL 01C - Other Baby Products 1 VITIS VINIFERA (GRAPE) SEED OIL 02A - Bath Oils, Tablets, and Salts 4 VITIS VINIFERA (GRAPE) SEED OIL 02D - Other Bath Preparations 3 VITIS VINIFERA (GRAPE) SEED OIL 03C - Eye Shadow 1 VITIS VINIFERA (GRAPE) SEED OIL 03D - Eye Lotion 4 VITIS VINIFERA (GRAPE) SEED OIL 03G - Other Eye Makeup Preparations 3 VITIS VINIFERA (GRAPE) SEED OIL 04E - Other Fragrance Preparation 6 VITIS VINIFERA (GRAPE) SEED OIL 05A - Hair Conditioner 17 VITIS VINIFERA (GRAPE) SEED OIL 05F - Shampoos (non-coloring) 6 VITIS VINIFERA (GRAPE) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 9 VITIS VINIFERA (GRAPE) SEED OIL 05I - Other Hair Preparations 14 VITIS VINIFERA (GRAPE) SEED OIL 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests) 4 VITIS VINIFERA (GRAPE) SEED OIL 06D - Hair Shampoos (coloring) 1 VITIS VINIFERA (GRAPE) SEED OIL 06G - Hair Bleaches 2 VITIS VINIFERA (GRAPE) SEED OIL 06H - Other Hair Coloring Preparation 3 VITIS VINIFERA (GRAPE) SEED OIL 07A - Blushers (all types) 1 VITIS VINIFERA (GRAPE) SEED OIL 07B - Face Powders 2 VITIS VINIFERA (GRAPE) SEED OIL 07E - Lipstick 34 VITIS VINIFERA (GRAPE) SEED OIL 07I - Other Makeup Preparations 6 VITIS VINIFERA (GRAPE) SEED OIL 08B - Cuticle Softeners 2 VITIS VINIFERA (GRAPE) SEED OIL 08C - Nail Creams and Lotions 3 VITIS VINIFERA (GRAPE) SEED OIL 08E - Nail Polish and Enamel 1 VITIS VINIFERA (GRAPE) SEED OIL 08G - Other Manicuring Preparations 2 VITIS VINIFERA (GRAPE) SEED OIL 10A - Bath Soaps and Detergents 15 VITIS VINIFERA (GRAPE) SEED OIL 10E - Other Personal Cleanliness Products 19 VITIS VINIFERA (GRAPE) SEED OIL 11A - Aftershave Lotion 1 VITIS VINIFERA (GRAPE) SEED OIL 11D - Preshave Lotions (all types) 1 VITIS VINIFERA (GRAPE) SEED OIL 11E - Shaving Cream 3 VITIS VINIFERA (GRAPE) SEED OIL 11G - Other Shaving Preparation Products 2 VITIS VINIFERA (GRAPE) SEED OIL 12A - Cleansing 11 VITIS VINIFERA (GRAPE) SEED OIL 12C - Face and Neck (exc shave) 18 VITIS VINIFERA (GRAPE) SEED OIL 12D - Body and Hand (exc shave) 59 VITIS VINIFERA (GRAPE) SEED OIL 12F - Moisturizing 134 VITIS VINIFERA (GRAPE) SEED OIL 12G - Night 15 VITIS VINIFERA (GRAPE) SEED OIL 12H - Paste Masks (mud packs) 6 VITIS VINIFERA (GRAPE) SEED OIL 12I - Skin Fresheners 5 VITIS VINIFERA (GRAPE) SEED OIL 12J - Other Skin Care Preps 27 VITIS VINIFERA (GRAPE) SEED OIL 13A - Suntan Gels, Creams, and Liquids 1 VITIS VINIFERA (GRAPE) SEED OIL 13B - Indoor Tanning Preparations 15

SODIUM GRAPESEEDATE 12J - Other Skin Care Preps 4

HYDROGENATED GRAPESEED OIL 05A - Hair Conditioner 1 HYDROGENATED GRAPESEED OIL 07E - Lipstick 1 HYDROGENATED GRAPESEED OIL 07I - Other Makeup Preparations 1 HYDROGENATED GRAPESEED OIL 08B - Cuticle Softeners 1 HYDROGENATED GRAPESEED OIL 10A - Bath Soaps and Detergents 1 HYDROGENATED GRAPESEED OIL 12A - Cleansing 1 HYDROGENATED GRAPESEED OIL 13A - Suntan Gels, Creams, and Liquids 1

CIR Panel Book Page 82 2010 FDA VCRP Raw Data

BASSIA LATIFOLIA SEED BUTTER 03C - Eye Shadow 4 BASSIA LATIFOLIA SEED BUTTER 07A - Blushers (all types) 1 BASSIA LATIFOLIA SEED BUTTER 07B - Face Powders 5 BASSIA LATIFOLIA SEED BUTTER 10A - Bath Soaps and Detergents 1 BASSIA LATIFOLIA SEED BUTTER 10E - Other Personal Cleanliness Products 4 BASSIA LATIFOLIA SEED BUTTER 12F - Moisturizing 7

CAMELLIA KISSI SEED OIL 02A - Bath Oils, Tablets, and Salts 1 CAMELLIA KISSI SEED OIL 03C - Eye Shadow 4 CAMELLIA KISSI SEED OIL 05A - Hair Conditioner 3 CAMELLIA KISSI SEED OIL 05E - Rinses (non-coloring) 1 CAMELLIA KISSI SEED OIL 05F - Shampoos (non-coloring) 2 CAMELLIA KISSI SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 2 CAMELLIA KISSI SEED OIL 05I - Other Hair Preparations 3 CAMELLIA KISSI SEED OIL 07A - Blushers (all types) 2 CAMELLIA KISSI SEED OIL 07B - Face Powders 1 CAMELLIA KISSI SEED OIL 07E - Lipstick 1 CAMELLIA KISSI SEED OIL 10A - Bath Soaps and Detergents 1 CAMELLIA KISSI SEED OIL 12A - Cleansing 4 CAMELLIA KISSI SEED OIL 12C - Face and Neck (exc shave) 3 CAMELLIA KISSI SEED OIL 12D - Body and Hand (exc shave) 7 CAMELLIA KISSI SEED OIL 12F - Moisturizing 7 CAMELLIA KISSI SEED OIL 12G - Night 2 CAMELLIA KISSI SEED OIL 12H - Paste Masks (mud packs) 1 CAMELLIA KISSI SEED OIL 12J - Other Skin Care Preps 2

CRAMBE ABYSSINICA SEED OIL 03G - Other Eye Makeup Preparations 1 CRAMBE ABYSSINICA SEED OIL 05A - Hair Conditioner 5 CRAMBE ABYSSINICA SEED OIL 05C - Hair Straighteners 1 CRAMBE ABYSSINICA SEED OIL 05F - Shampoos (non-coloring) 1 CRAMBE ABYSSINICA SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 5 CRAMBE ABYSSINICA SEED OIL 05I - Other Hair Preparations 2 CRAMBE ABYSSINICA SEED OIL 06H - Other Hair Coloring Preparation 4 CRAMBE ABYSSINICA SEED OIL 07E - Lipstick 1 CRAMBE ABYSSINICA SEED OIL 12C - Face and Neck (exc shave) 2 CRAMBE ABYSSINICA SEED OIL 12D - Body and Hand (exc shave) 1 CRAMBE ABYSSINICA SEED OIL 12G - Night 3

GARCINIA INDICA SEED BUTTER 03D - Eye Lotion 1 GARCINIA INDICA SEED BUTTER 07E - Lipstick 3 GARCINIA INDICA SEED BUTTER 07I - Other Makeup Preparations 5 GARCINIA INDICA SEED BUTTER 10A - Bath Soaps and Detergents 1 GARCINIA INDICA SEED BUTTER 11F - Shaving Soap 2 GARCINIA INDICA SEED BUTTER 12C - Face and Neck (exc shave) 2 GARCINIA INDICA SEED BUTTER 12D - Body and Hand (exc shave) 2 GARCINIA INDICA SEED BUTTER 12F - Moisturizing 9 GARCINIA INDICA SEED BUTTER 12J - Other Skin Care Preps 5

HIPPOPHAE RHAMNOIDES FRUIT OIL 03D - Eye Lotion 1 HIPPOPHAE RHAMNOIDES FRUIT OIL 08G - Other Manicuring Preparations 1 HIPPOPHAE RHAMNOIDES FRUIT OIL 12C - Face and Neck (exc shave) 3 HIPPOPHAE RHAMNOIDES FRUIT OIL 12F - Moisturizing 2

HIPPOPHAE RHAMNOIDES OIL 05A - Hair Conditioner 3 HIPPOPHAE RHAMNOIDES OIL 05F - Shampoos (non-coloring) 1 HIPPOPHAE RHAMNOIDES OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 2 HIPPOPHAE RHAMNOIDES OIL 08A - Basecoats and Undercoats 1 HIPPOPHAE RHAMNOIDES OIL 08B - Cuticle Softeners 1 HIPPOPHAE RHAMNOIDES OIL 08E - Nail Polish and Enamel 3

CIR Panel Book Page 83 2010 FDA VCRP Raw Data

HIPPOPHAE RHAMNOIDES OIL 08G - Other Manicuring Preparations 3 HIPPOPHAE RHAMNOIDES OIL 10E - Other Personal Cleanliness Products 1

LUFFA CYLINDRICA SEED OIL 03C - Eye Shadow 1 LUFFA CYLINDRICA SEED OIL 07A - Blushers (all types) 3 LUFFA CYLINDRICA SEED OIL 07B - Face Powders 1 LUFFA CYLINDRICA SEED OIL 07E - Lipstick 9 LUFFA CYLINDRICA SEED OIL 12C - Face and Neck (exc shave) 2 LUFFA CYLINDRICA SEED OIL 12F - Moisturizing 1 LUFFA CYLINDRICA SEED OIL 12G - Night 1 LUFFA CYLINDRICA SEED OIL 13B - Indoor Tanning Preparations 1 LUFFA CYLINDRICA SEED OIL 13C - Other Suntan Preparations 2

LUPINUS ALBUS SEED OIL 13C - Other Suntan Preparations 1

LYCIUM BARBARUM SEED OIL 03G - Other Eye Makeup Preparations 1 LYCIUM BARBARUM SEED OIL 07E - Lipstick 1

ORBIGNYA SPECIOSA KERNEL OIL 05A - Hair Conditioner 2 ORBIGNYA SPECIOSA KERNEL OIL 05F - Shampoos (non-coloring) 2 ORBIGNYA SPECIOSA KERNEL OIL 05I - Other Hair Preparations 1 ORBIGNYA SPECIOSA KERNEL OIL 06H - Other Hair Coloring Preparation 3

PASSIFLORA EDULIS SEED OIL 03C - Eye Shadow 1 PASSIFLORA EDULIS SEED OIL 03D - Eye Lotion 2 PASSIFLORA EDULIS SEED OIL 05A - Hair Conditioner 2 PASSIFLORA EDULIS SEED OIL 05B - Hair Spray (aerosol fixatives) 3 PASSIFLORA EDULIS SEED OIL 05F - Shampoos (non-coloring) 1 PASSIFLORA EDULIS SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 PASSIFLORA EDULIS SEED OIL 05I - Other Hair Preparations 3 PASSIFLORA EDULIS SEED OIL 06H - Other Hair Coloring Preparation 3 PASSIFLORA EDULIS SEED OIL 07B - Face Powders 2 PASSIFLORA EDULIS SEED OIL 07E - Lipstick 14 PASSIFLORA EDULIS SEED OIL 10E - Other Personal Cleanliness Products 1 PASSIFLORA EDULIS SEED OIL 12A - Cleansing 2 PASSIFLORA EDULIS SEED OIL 12C - Face and Neck (exc shave) 6 PASSIFLORA EDULIS SEED OIL 12D - Body and Hand (exc shave) 2 PASSIFLORA EDULIS SEED OIL 12F - Moisturizing 16 PASSIFLORA EDULIS SEED OIL 12G - Night 1 PASSIFLORA EDULIS SEED OIL 12J - Other Skin Care Preps 2

PUNICA GRANATUM SEED OIL 03D - Eye Lotion 2 PUNICA GRANATUM SEED OIL 07A - Blushers (all types) 1 PUNICA GRANATUM SEED OIL 07E - Lipstick 30 PUNICA GRANATUM SEED OIL 10A - Bath Soaps and Detergents 2 PUNICA GRANATUM SEED OIL 12C - Face and Neck (exc shave) 3 PUNICA GRANATUM SEED OIL 12F - Moisturizing 5 PUNICA GRANATUM SEED OIL 12G - Night 1 PUNICA GRANATUM SEED OIL 12J - Other Skin Care Preps 2

ROSA CANINA FRUIT OIL 02B - Bubble Baths 1 ROSA CANINA FRUIT OIL 03B - Eyeliner 4 ROSA CANINA FRUIT OIL 03D - Eye Lotion 7 ROSA CANINA FRUIT OIL 03F - Mascara 2 ROSA CANINA FRUIT OIL 03G - Other Eye Makeup Preparations 4 ROSA CANINA FRUIT OIL 04E - Other Fragrance Preparation 1 ROSA CANINA FRUIT OIL 05A - Hair Conditioner 4 ROSA CANINA FRUIT OIL 05F - Shampoos (non-coloring) 2

CIR Panel Book Page 84 2010 FDA VCRP Raw Data

ROSA CANINA FRUIT OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 ROSA CANINA FRUIT OIL 05I - Other Hair Preparations 2 ROSA CANINA FRUIT OIL 07C - Foundations 3 ROSA CANINA FRUIT OIL 07E - Lipstick 7 ROSA CANINA FRUIT OIL 07I - Other Makeup Preparations 2 ROSA CANINA FRUIT OIL 08G - Other Manicuring Preparations 1 ROSA CANINA FRUIT OIL 10A - Bath Soaps and Detergents 3 ROSA CANINA FRUIT OIL 12A - Cleansing 4 ROSA CANINA FRUIT OIL 12C - Face and Neck (exc shave) 23 ROSA CANINA FRUIT OIL 12D - Body and Hand (exc shave) 7 ROSA CANINA FRUIT OIL 12F - Moisturizing 22 ROSA CANINA FRUIT OIL 12G - Night 9 ROSA CANINA FRUIT OIL 12H - Paste Masks (mud packs) 1 ROSA CANINA FRUIT OIL 12I - Skin Fresheners 7 ROSA CANINA FRUIT OIL 12J - Other Skin Care Preps 3 ROSA CANINA FRUIT OIL 13B - Indoor Tanning Preparations 1

RUBUS CHAMAEMORUS SEED OIL 12C - Face and Neck (exc shave) 2 RUBUS CHAMAEMORUS SEED OIL 12G - Night 1

VACCINIUM MYRTILLUS SEED OIL 07E - Lipstick 29 VACCINIUM MYRTILLUS SEED OIL 12A - Cleansing 1 VACCINIUM MYRTILLUS SEED OIL 12D - Body and Hand (exc shave) 1 VACCINIUM MYRTILLUS SEED OIL 12F - Moisturizing 2

VACCINIUM VITIS-IDAEA SEED OIL 08A - Basecoats and Undercoats 1 VACCINIUM VITIS-IDAEA SEED OIL 08B - Cuticle Softeners 1 VACCINIUM VITIS-IDAEA SEED OIL 08E - Nail Polish and Enamel 3 VACCINIUM VITIS-IDAEA SEED OIL 08G - Other Manicuring Preparations 3 VACCINIUM VITIS-IDAEA SEED OIL 12D - Body and Hand (exc shave) 1

VANILLA PLANIFOLIA FRUIT OIL 03D - Eye Lotion 1 VANILLA PLANIFOLIA FRUIT OIL 03G - Other Eye Makeup Preparations 1 VANILLA PLANIFOLIA FRUIT OIL 07I - Other Makeup Preparations 2 VANILLA PLANIFOLIA FRUIT OIL 10E - Other Personal Cleanliness Products 1 VANILLA PLANIFOLIA FRUIT OIL 12F - Moisturizing 4

CIR Panel Book Page 85 2010 FDA VCRP Raw Data

CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 5 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 01C - Other Baby Products 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 02A - Bath Oils, Tablets, and Salts 2 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 02D - Other Bath Preparations 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 03B - Eyeliner 6 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 03C - Eye Shadow 4 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 03D - Eye Lotion 2 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 03G - Other Eye Makeup Preparations 3 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 04E - Other Fragrance Preparation 5 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 05A - Hair Conditioner 26 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 05C - Hair Straighteners 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 05F - Shampoos (non-coloring) 10 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 37 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 05I - Other Hair Preparations 5 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 06H - Other Hair Coloring Preparation 2 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 07A - Blushers (all types) 11 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 07B - Face Powders 3 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 07C - Foundations 3 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 07E - Lipstick 83 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 07F - Makeup Bases 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 07I - Other Makeup Preparations 7 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 08A - Basecoats and Undercoats 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 08B - Cuticle Softeners 4 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 08C - Nail Creams and Lotions 2 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 08E - Nail Polish and Enamel 16 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 08G - Other Manicuring Preparations 9 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 10A - Bath Soaps and Detergents 19 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 10E - Other Personal Cleanliness Products 12 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 11A - Aftershave Lotion 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 11D - Preshave Lotions (all types) 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 11E - Shaving Cream 1 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12A - Cleansing 22 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12B - Depilatories 4 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12C - Face and Neck (exc shave) 15 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12D - Body and Hand (exc shave) 62 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12F - Moisturizing 70 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12G - Night 5 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12H - Paste Masks (mud packs) 5 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12I - Skin Fresheners 3 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 12J - Other Skin Care Preps 33 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 13B - Indoor Tanning Preparations 4 CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL 13C - Other Suntan Preparations 1 HYBRID SAFFLOWER OIL 05A - Hair Conditioner 2 HYBRID SAFFLOWER OIL 12A - Cleansing 1 HYBRID SAFFLOWER OIL 12C - Face and Neck (exc shave) 1 HYBRID SAFFLOWER OIL 12D - Body and Hand (exc shave) 2 HYBRID SAFFLOWER OIL 12F - Moisturizing 4 HYBRID SAFFLOWER OIL 12G - Night 1 HYBRID SAFFLOWER OIL 12H - Paste Masks (mud packs) 1 HYBRID SAFFLOWER OIL 12J - Other Skin Care Preps 1 HYBRID SAFFLOWER OIL 13A - Suntan Gels, Creams, and Liquids 1

ELAEIS GUINEENSIS (PALM) OIL 01B - Baby Lotions, Oils, Powders, and Creams 1 ELAEIS GUINEENSIS (PALM) OIL 01C - Other Baby Products 1 ELAEIS GUINEENSIS (PALM) OIL 03A - Eyebrow Pencil 5 ELAEIS GUINEENSIS (PALM) OIL 03B - Eyeliner 1 ELAEIS GUINEENSIS (PALM) OIL 03D - Eye Lotion 3 ELAEIS GUINEENSIS (PALM) OIL 03G - Other Eye Makeup Preparations 3 ELAEIS GUINEENSIS (PALM) OIL 05A - Hair Conditioner 16 ELAEIS GUINEENSIS (PALM) OIL 05B - Hair Spray (aerosol fixatives) 3 ELAEIS GUINEENSIS (PALM) OIL 05F - Shampoos (non-coloring) 3 ELAEIS GUINEENSIS (PALM) OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 4

CIR Panel Book Page 86 2010 FDA VCRP Raw Data

ELAEIS GUINEENSIS (PALM) OIL 05I - Other Hair Preparations 17 ELAEIS GUINEENSIS (PALM) OIL 07E - Lipstick 11 ELAEIS GUINEENSIS (PALM) OIL 07H - Makeup Fixatives 3 ELAEIS GUINEENSIS (PALM) OIL 07I - Other Makeup Preparations 8 ELAEIS GUINEENSIS (PALM) OIL 10A - Bath Soaps and Detergents 59 ELAEIS GUINEENSIS (PALM) OIL 10E - Other Personal Cleanliness Products 9 ELAEIS GUINEENSIS (PALM) OIL 11A - Aftershave Lotion 7 ELAEIS GUINEENSIS (PALM) OIL 11E - Shaving Cream 4 ELAEIS GUINEENSIS (PALM) OIL 12A - Cleansing 8 ELAEIS GUINEENSIS (PALM) OIL 12C - Face and Neck (exc shave) 17 ELAEIS GUINEENSIS (PALM) OIL 12D - Body and Hand (exc shave) 34 ELAEIS GUINEENSIS (PALM) OIL 12F - Moisturizing 28 ELAEIS GUINEENSIS (PALM) OIL 12G - Night 6 ELAEIS GUINEENSIS (PALM) OIL 12H - Paste Masks (mud packs) 2 ELAEIS GUINEENSIS (PALM) OIL 12J - Other Skin Care Preps 13 ELAEIS GUINEENSIS (PALM) OIL 13B - Indoor Tanning Preparations 5 ELAEIS GUINEENSIS (PALM) OIL 13C - Other Suntan Preparations 1

ELAEIS GUINEENSIS (PALM) KERNEL OIL 02B - Bubble Baths 1 ELAEIS GUINEENSIS (PALM) KERNEL OIL 03A - Eyebrow Pencil 5 ELAEIS GUINEENSIS (PALM) KERNEL OIL 03B - Eyeliner 1 ELAEIS GUINEENSIS (PALM) KERNEL OIL 03D - Eye Lotion 2 ELAEIS GUINEENSIS (PALM) KERNEL OIL 03G - Other Eye Makeup Preparations 2 ELAEIS GUINEENSIS (PALM) KERNEL OIL 05A - Hair Conditioner 5 ELAEIS GUINEENSIS (PALM) KERNEL OIL 05F - Shampoos (non-coloring) 1 ELAEIS GUINEENSIS (PALM) KERNEL OIL 07E - Lipstick 6 ELAEIS GUINEENSIS (PALM) KERNEL OIL 07H - Makeup Fixatives 3 ELAEIS GUINEENSIS (PALM) KERNEL OIL 07I - Other Makeup Preparations 8 ELAEIS GUINEENSIS (PALM) KERNEL OIL 10A - Bath Soaps and Detergents 9 ELAEIS GUINEENSIS (PALM) KERNEL OIL 12A - Cleansing 1 ELAEIS GUINEENSIS (PALM) KERNEL OIL 12C - Face and Neck (exc shave) 7 ELAEIS GUINEENSIS (PALM) KERNEL OIL 12D - Body and Hand (exc shave) 9 ELAEIS GUINEENSIS (PALM) KERNEL OIL 12F - Moisturizing 12 ELAEIS GUINEENSIS (PALM) KERNEL OIL 12G - Night 2 ELAEIS GUINEENSIS (PALM) KERNEL OIL 12J - Other Skin Care Preps 1 ELAEIS GUINEENSIS (PALM) KERNEL OIL 13B - Indoor Tanning Preparations 2

HYDROGENATED PALM OIL 03A - Eyebrow Pencil 13 HYDROGENATED PALM OIL 03B - Eyeliner 9 HYDROGENATED PALM OIL 03D - Eye Lotion 2 HYDROGENATED PALM OIL 03F - Mascara 29 HYDROGENATED PALM OIL 03G - Other Eye Makeup Preparations 8 HYDROGENATED PALM OIL 07C - Foundations 1 HYDROGENATED PALM OIL 07E - Lipstick 12 HYDROGENATED PALM OIL 07H - Makeup Fixatives 3 HYDROGENATED PALM OIL 07I - Other Makeup Preparations 13 HYDROGENATED PALM OIL 10A - Bath Soaps and Detergents 15 HYDROGENATED PALM OIL 10E - Other Personal Cleanliness Products 2 HYDROGENATED PALM OIL 11F - Shaving Soap 1 HYDROGENATED PALM OIL 12C - Face and Neck (exc shave) 9 HYDROGENATED PALM OIL 12D - Body and Hand (exc shave) 9 HYDROGENATED PALM OIL 12F - Moisturizing 17 HYDROGENATED PALM OIL 12G - Night 4 HYDROGENATED PALM OIL 12J - Other Skin Care Preps 2 HYDROGENATED PALM OIL 13A - Suntan Gels, Creams, and Liquids 1 HYDROGENATED PALM OIL 13B - Indoor Tanning Preparations 2

HYDROGENATED PALM KERNEL OIL 03A - Eyebrow Pencil 1 HYDROGENATED PALM KERNEL OIL 03G - Other Eye Makeup Preparations 1 HYDROGENATED PALM KERNEL OIL 04E - Other Fragrance Preparation 1 HYDROGENATED PALM KERNEL OIL 07E - Lipstick 5 HYDROGENATED PALM KERNEL OIL 10A - Bath Soaps and Detergents 2

CIR Panel Book Page 87 2010 FDA VCRP Raw Data

HYDROGENATED PALM KERNEL OIL 12C - Face and Neck (exc shave) 6 HYDROGENATED PALM KERNEL OIL 12D - Body and Hand (exc shave) 10 HYDROGENATED PALM KERNEL OIL 12F - Moisturizing 13 HYDROGENATED PALM KERNEL OIL 12G - Night 1 HYDROGENATED PALM KERNEL OIL 12J - Other Skin Care Preps 5 HYDROGENATED PALM KERNEL OIL 13A - Suntan Gels, Creams, and Liquids 2

GOSSYPIUM HERBACEUM (COTTON) SEED OIL 03B - Eyeliner 2 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 03F - Mascara 2 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 04B - Perfumes 1 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 04E - Other Fragrance Preparation 10 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 05I - Other Hair Preparations 2 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 07C - Foundations 1 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 07E - Lipstick 9 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 08B - Cuticle Softeners 1 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 10A - Bath Soaps and Detergents 5 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 10B - Deodorants (underarm) 1 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 10E - Other Personal Cleanliness Products 2 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 11E - Shaving Cream 4 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 12A - Cleansing 3 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 12C - Face and Neck (exc shave) 3 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 12D - Body and Hand (exc shave) 14 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 12E - Foot Powders and Sprays 1 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 12F - Moisturizing 10 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 12H - Paste Masks (mud packs) 1 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 12J - Other Skin Care Preps 8 GOSSYPIUM HERBACEUM (COTTON) SEED OIL 13B - Indoor Tanning Preparations 3

HYDROGENATED COTTONSEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 8 HYDROGENATED COTTONSEED OIL 03A - Eyebrow Pencil 32 HYDROGENATED COTTONSEED OIL 03B - Eyeliner 87 HYDROGENATED COTTONSEED OIL 03C - Eye Shadow 18 HYDROGENATED COTTONSEED OIL 03D - Eye Lotion 1 HYDROGENATED COTTONSEED OIL 03F - Mascara 2 HYDROGENATED COTTONSEED OIL 03G - Other Eye Makeup Preparations 15 HYDROGENATED COTTONSEED OIL 05A - Hair Conditioner 3 HYDROGENATED COTTONSEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 1 HYDROGENATED COTTONSEED OIL 07D - Leg and Body Paints 1 HYDROGENATED COTTONSEED OIL 07E - Lipstick 168 HYDROGENATED COTTONSEED OIL 07I - Other Makeup Preparations 13 HYDROGENATED COTTONSEED OIL 12F - Moisturizing 9 HYDROGENATED COTTONSEED OIL 12H - Paste Masks (mud packs) 1 HYDROGENATED COTTONSEED OIL 12I - Skin Fresheners 1 HYDROGENATED COTTONSEED OIL 12J - Other Skin Care Preps 2

ORYZA SATIVA (RICE) BRAN OIL 01B - Baby Lotions, Oils, Powders, and Creams 1 ORYZA SATIVA (RICE) BRAN OIL 01C - Other Baby Products 1 ORYZA SATIVA (RICE) BRAN OIL 02A - Bath Oils, Tablets, and Salts 6 ORYZA SATIVA (RICE) BRAN OIL 02B - Bubble Baths 1 ORYZA SATIVA (RICE) BRAN OIL 02D - Other Bath Preparations 10 ORYZA SATIVA (RICE) BRAN OIL 03D - Eye Lotion 1 ORYZA SATIVA (RICE) BRAN OIL 03F - Mascara 3 ORYZA SATIVA (RICE) BRAN OIL 03G - Other Eye Makeup Preparations 1 ORYZA SATIVA (RICE) BRAN OIL 04E - Other Fragrance Preparation 6 ORYZA SATIVA (RICE) BRAN OIL 05A - Hair Conditioner 13 ORYZA SATIVA (RICE) BRAN OIL 05B - Hair Spray (aerosol fixatives) 4 ORYZA SATIVA (RICE) BRAN OIL 05E - Rinses (non-coloring) 1 ORYZA SATIVA (RICE) BRAN OIL 05F - Shampoos (non-coloring) 10 ORYZA SATIVA (RICE) BRAN OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 11 ORYZA SATIVA (RICE) BRAN OIL 05I - Other Hair Preparations 3 ORYZA SATIVA (RICE) BRAN OIL 07C - Foundations 1 ORYZA SATIVA (RICE) BRAN OIL 07E - Lipstick 17

CIR Panel Book Page 88 2010 FDA VCRP Raw Data

ORYZA SATIVA (RICE) BRAN OIL 07I - Other Makeup Preparations 2 ORYZA SATIVA (RICE) BRAN OIL 08B - Cuticle Softeners 2 ORYZA SATIVA (RICE) BRAN OIL 08G - Other Manicuring Preparations 3 ORYZA SATIVA (RICE) BRAN OIL 10A - Bath Soaps and Detergents 39 ORYZA SATIVA (RICE) BRAN OIL 10E - Other Personal Cleanliness Products 9 ORYZA SATIVA (RICE) BRAN OIL 11G - Other Shaving Preparation Products 1 ORYZA SATIVA (RICE) BRAN OIL 12A - Cleansing 9 ORYZA SATIVA (RICE) BRAN OIL 12C - Face and Neck (exc shave) 22 ORYZA SATIVA (RICE) BRAN OIL 12D - Body and Hand (exc shave) 50 ORYZA SATIVA (RICE) BRAN OIL 12E - Foot Powders and Sprays 1 ORYZA SATIVA (RICE) BRAN OIL 12F - Moisturizing 88 ORYZA SATIVA (RICE) BRAN OIL 12G - Night 11 ORYZA SATIVA (RICE) BRAN OIL 12H - Paste Masks (mud packs) 5 ORYZA SATIVA (RICE) BRAN OIL 12J - Other Skin Care Preps 34 ORYZA SATIVA (RICE) BRAN OIL 13A - Suntan Gels, Creams, and Liquids 1 ORYZA SATIVA (RICE) BRAN OIL 13B - Indoor Tanning Preparations 1 ORYZA SATIVA (RICE) BRAN OIL 13C - Other Suntan Preparations 3

ORYZA SATIVA (RICE) GERM OIL 02A - Bath Oils, Tablets, and Salts 1 ORYZA SATIVA (RICE) GERM OIL 03F - Mascara 2 ORYZA SATIVA (RICE) GERM OIL 07E - Lipstick 4 ORYZA SATIVA (RICE) GERM OIL 07I - Other Makeup Preparations 1 ORYZA SATIVA (RICE) GERM OIL 10E - Other Personal Cleanliness Products 1 ORYZA SATIVA (RICE) GERM OIL 12A - Cleansing 3 ORYZA SATIVA (RICE) GERM OIL 12C - Face and Neck (exc shave) 11 ORYZA SATIVA (RICE) GERM OIL 12D - Body and Hand (exc shave) 5 ORYZA SATIVA (RICE) GERM OIL 12F - Moisturizing 4 ORYZA SATIVA (RICE) GERM OIL 12J - Other Skin Care Preps 2

SESAMUM INDICUM (SESAME) SEED OIL 01B - Baby Lotions, Oils, Powders, and Creams 3 SESAMUM INDICUM (SESAME) SEED OIL 02A - Bath Oils, Tablets, and Salts 2 SESAMUM INDICUM (SESAME) SEED OIL 02D - Other Bath Preparations 3 SESAMUM INDICUM (SESAME) SEED OIL 03B - Eyeliner 2 SESAMUM INDICUM (SESAME) SEED OIL 03C - Eye Shadow 2 SESAMUM INDICUM (SESAME) SEED OIL 03D - Eye Lotion 4 SESAMUM INDICUM (SESAME) SEED OIL 03E - Eye Makeup Remover 1 SESAMUM INDICUM (SESAME) SEED OIL 03G - Other Eye Makeup Preparations 5 SESAMUM INDICUM (SESAME) SEED OIL 04C - Powders (dusting and talcum, excluding aftershave talc) 1 SESAMUM INDICUM (SESAME) SEED OIL 04E - Other Fragrance Preparation 1 SESAMUM INDICUM (SESAME) SEED OIL 05A - Hair Conditioner 12 SESAMUM INDICUM (SESAME) SEED OIL 05B - Hair Spray (aerosol fixatives) 3 SESAMUM INDICUM (SESAME) SEED OIL 05F - Shampoos (non-coloring) 16 SESAMUM INDICUM (SESAME) SEED OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 10 SESAMUM INDICUM (SESAME) SEED OIL 05H - Wave Sets 1 SESAMUM INDICUM (SESAME) SEED OIL 05I - Other Hair Preparations 17 SESAMUM INDICUM (SESAME) SEED OIL 07C - Foundations 11 SESAMUM INDICUM (SESAME) SEED OIL 07E - Lipstick 52 SESAMUM INDICUM (SESAME) SEED OIL 07F - Makeup Bases 23 SESAMUM INDICUM (SESAME) SEED OIL 07H - Makeup Fixatives 1 SESAMUM INDICUM (SESAME) SEED OIL 07I - Other Makeup Preparations 5 SESAMUM INDICUM (SESAME) SEED OIL 08B - Cuticle Softeners 2 SESAMUM INDICUM (SESAME) SEED OIL 08C - Nail Creams and Lotions 2 SESAMUM INDICUM (SESAME) SEED OIL 08G - Other Manicuring Preparations 3 SESAMUM INDICUM (SESAME) SEED OIL 10A - Bath Soaps and Detergents 20 SESAMUM INDICUM (SESAME) SEED OIL 10E - Other Personal Cleanliness Products 8 SESAMUM INDICUM (SESAME) SEED OIL 11A - Aftershave Lotion 3 SESAMUM INDICUM (SESAME) SEED OIL 11B - Beard Softeners 1 SESAMUM INDICUM (SESAME) SEED OIL 11D - Preshave Lotions (all types) 1 SESAMUM INDICUM (SESAME) SEED OIL 11E - Shaving Cream 4 SESAMUM INDICUM (SESAME) SEED OIL 12A - Cleansing 16 SESAMUM INDICUM (SESAME) SEED OIL 12C - Face and Neck (exc shave) 24 SESAMUM INDICUM (SESAME) SEED OIL 12D - Body and Hand (exc shave) 76 SESAMUM INDICUM (SESAME) SEED OIL 12F - Moisturizing 74

CIR Panel Book Page 89 2010 FDA VCRP Raw Data

SESAMUM INDICUM (SESAME) SEED OIL 12G - Night 14 SESAMUM INDICUM (SESAME) SEED OIL 12H - Paste Masks (mud packs) 5 SESAMUM INDICUM (SESAME) SEED OIL 12J - Other Skin Care Preps 41 SESAMUM INDICUM (SESAME) SEED OIL 13A - Suntan Gels, Creams, and Liquids 6 SESAMUM INDICUM (SESAME) SEED OIL 13B - Indoor Tanning Preparations 3 SESAMUM INDICUM (SESAME) SEED OIL 13C - Other Suntan Preparations 2

SESAMUM INDICUM (SESAME) OIL UNSAPONIFIABLES 07E - Lipstick 11 SESAMUM INDICUM (SESAME) OIL UNSAPONIFIABLES 12C - Face and Neck (exc shave) 4 SESAMUM INDICUM (SESAME) OIL UNSAPONIFIABLES 12D - Body and Hand (exc shave) 1 SESAMUM INDICUM (SESAME) OIL UNSAPONIFIABLES 12F - Moisturizing 1

ZEA MAYS (CORN) OIL 01B - Baby Lotions, Oils, Powders, and Creams 5 ZEA MAYS (CORN) OIL 01C - Other Baby Products 3 ZEA MAYS (CORN) OIL 03C - Eye Shadow 17 ZEA MAYS (CORN) OIL 03D - Eye Lotion 7 ZEA MAYS (CORN) OIL 03E - Eye Makeup Remover 4 ZEA MAYS (CORN) OIL 03F - Mascara 1 ZEA MAYS (CORN) OIL 03G - Other Eye Makeup Preparations 6 ZEA MAYS (CORN) OIL 05A - Hair Conditioner 11 ZEA MAYS (CORN) OIL 05B - Hair Spray (aerosol fixatives) 1 ZEA MAYS (CORN) OIL 05E - Rinses (non-coloring) 1 ZEA MAYS (CORN) OIL 05F - Shampoos (non-coloring) 12 ZEA MAYS (CORN) OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 11 ZEA MAYS (CORN) OIL 05I - Other Hair Preparations 4 ZEA MAYS (CORN) OIL 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests)178 ZEA MAYS (CORN) OIL 06B - Hair Tints 1 ZEA MAYS (CORN) OIL 06C - Hair Rinses (coloring) 1 ZEA MAYS (CORN) OIL 06G - Hair Bleaches 1 ZEA MAYS (CORN) OIL 06H - Other Hair Coloring Preparation 2 ZEA MAYS (CORN) OIL 07A - Blushers (all types) 22 ZEA MAYS (CORN) OIL 07B - Face Powders 31 ZEA MAYS (CORN) OIL 07C - Foundations 11 ZEA MAYS (CORN) OIL 07E - Lipstick 30 ZEA MAYS (CORN) OIL 07I - Other Makeup Preparations 7 ZEA MAYS (CORN) OIL 08B - Cuticle Softeners 1 ZEA MAYS (CORN) OIL 08E - Nail Polish and Enamel 1 ZEA MAYS (CORN) OIL 08G - Other Manicuring Preparations 1 ZEA MAYS (CORN) OIL 10A - Bath Soaps and Detergents 2 ZEA MAYS (CORN) OIL 10B - Deodorants (underarm) 4 ZEA MAYS (CORN) OIL 12A - Cleansing 13 ZEA MAYS (CORN) OIL 12C - Face and Neck (exc shave) 53 ZEA MAYS (CORN) OIL 12D - Body and Hand (exc shave) 34 ZEA MAYS (CORN) OIL 12F - Moisturizing 68 ZEA MAYS (CORN) OIL 12G - Night 11 ZEA MAYS (CORN) OIL 12H - Paste Masks (mud packs) 11 ZEA MAYS (CORN) OIL 12I - Skin Fresheners 2 ZEA MAYS (CORN) OIL 12J - Other Skin Care Preps 24 ZEA MAYS (CORN) OIL 13A - Suntan Gels, Creams, and Liquids 1 ZEA MAYS (CORN) OIL 13B - Indoor Tanning Preparations 2 ZEA MAYS (CORN) OIL 13C - Other Suntan Preparations 3

ZEA MAYS (CORN) GERM OIL 01B - Baby Lotions, Oils, Powders, and Creams 3 ZEA MAYS (CORN) GERM OIL 01C - Other Baby Products 1 ZEA MAYS (CORN) GERM OIL 02A - Bath Oils, Tablets, and Salts 4 ZEA MAYS (CORN) GERM OIL 05A - Hair Conditioner 1 ZEA MAYS (CORN) GERM OIL 05E - Rinses (non-coloring) 1 ZEA MAYS (CORN) GERM OIL 05F - Shampoos (non-coloring) 1 ZEA MAYS (CORN) GERM OIL 10A - Bath Soaps and Detergents 2 ZEA MAYS (CORN) GERM OIL 10E - Other Personal Cleanliness Products 1 ZEA MAYS (CORN) GERM OIL 12A - Cleansing 9 ZEA MAYS (CORN) GERM OIL 12C - Face and Neck (exc shave) 6

CIR Panel Book Page 90 2010 FDA VCRP Raw Data

ZEA MAYS (CORN) GERM OIL 12D - Body and Hand (exc shave) 4 ZEA MAYS (CORN) GERM OIL 12F - Moisturizing 16 ZEA MAYS (CORN) GERM OIL 12J - Other Skin Care Preps 3 ZEA MAYS (CORN) GERM OIL 13B - Indoor Tanning Preparations 1

ZEA MAYS (CORN) OIL UNSAPONIFIABLES 12D - Body and Hand (exc shave) 1

PERSEA GRATISSIMA (AVOCADO) OIL 01B - Baby Lotions, Oils, Powders, and Creams 7 PERSEA GRATISSIMA (AVOCADO) OIL 01C - Other Baby Products 2 PERSEA GRATISSIMA (AVOCADO) OIL 02A - Bath Oils, Tablets, and Salts 23 PERSEA GRATISSIMA (AVOCADO) OIL 02B - Bubble Baths 1 PERSEA GRATISSIMA (AVOCADO) OIL 02D - Other Bath Preparations 1 PERSEA GRATISSIMA (AVOCADO) OIL 03A - Eyebrow Pencil 2 PERSEA GRATISSIMA (AVOCADO) OIL 03B - Eyeliner 3 PERSEA GRATISSIMA (AVOCADO) OIL 03C - Eye Shadow 1 PERSEA GRATISSIMA (AVOCADO) OIL 03D - Eye Lotion 12 PERSEA GRATISSIMA (AVOCADO) OIL 03E - Eye Makeup Remover 1 PERSEA GRATISSIMA (AVOCADO) OIL 03F - Mascara 2 PERSEA GRATISSIMA (AVOCADO) OIL 03G - Other Eye Makeup Preparations 3 PERSEA GRATISSIMA (AVOCADO) OIL 04E - Other Fragrance Preparation 7 PERSEA GRATISSIMA (AVOCADO) OIL 05A - Hair Conditioner 58 PERSEA GRATISSIMA (AVOCADO) OIL 05B - Hair Spray (aerosol fixatives) 4 PERSEA GRATISSIMA (AVOCADO) OIL 05C - Hair Straighteners 10 PERSEA GRATISSIMA (AVOCADO) OIL 05D - Permanent Waves 1 PERSEA GRATISSIMA (AVOCADO) OIL 05F - Shampoos (non-coloring) 26 PERSEA GRATISSIMA (AVOCADO) OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 33 PERSEA GRATISSIMA (AVOCADO) OIL 05I - Other Hair Preparations 57 PERSEA GRATISSIMA (AVOCADO) OIL 07A - Blushers (all types) 2 PERSEA GRATISSIMA (AVOCADO) OIL 07C - Foundations 4 PERSEA GRATISSIMA (AVOCADO) OIL 07E - Lipstick 60 PERSEA GRATISSIMA (AVOCADO) OIL 07F - Makeup Bases 23 PERSEA GRATISSIMA (AVOCADO) OIL 07I - Other Makeup Preparations 14 PERSEA GRATISSIMA (AVOCADO) OIL 08A - Basecoats and Undercoats 1 PERSEA GRATISSIMA (AVOCADO) OIL 08B - Cuticle Softeners 2 PERSEA GRATISSIMA (AVOCADO) OIL 08C - Nail Creams and Lotions 1 PERSEA GRATISSIMA (AVOCADO) OIL 08D - Nail Extenders 1 PERSEA GRATISSIMA (AVOCADO) OIL 08F - Nail Polish and Enamel Removers 1 PERSEA GRATISSIMA (AVOCADO) OIL 08G - Other Manicuring Preparations 1 PERSEA GRATISSIMA (AVOCADO) OIL 10A - Bath Soaps and Detergents 30 PERSEA GRATISSIMA (AVOCADO) OIL 10E - Other Personal Cleanliness Products 13 PERSEA GRATISSIMA (AVOCADO) OIL 11A - Aftershave Lotion 2 PERSEA GRATISSIMA (AVOCADO) OIL 11E - Shaving Cream 4 PERSEA GRATISSIMA (AVOCADO) OIL 11F - Shaving Soap 2 PERSEA GRATISSIMA (AVOCADO) OIL 11G - Other Shaving Preparation Products 2 PERSEA GRATISSIMA (AVOCADO) OIL 12A - Cleansing 37 PERSEA GRATISSIMA (AVOCADO) OIL 12B - Depilatories 1 PERSEA GRATISSIMA (AVOCADO) OIL 12C - Face and Neck (exc shave) 35 PERSEA GRATISSIMA (AVOCADO) OIL 12D - Body and Hand (exc shave) 95 PERSEA GRATISSIMA (AVOCADO) OIL 12E - Foot Powders and Sprays 1 PERSEA GRATISSIMA (AVOCADO) OIL 12F - Moisturizing 199 PERSEA GRATISSIMA (AVOCADO) OIL 12G - Night 20 PERSEA GRATISSIMA (AVOCADO) OIL 12H - Paste Masks (mud packs) 14 PERSEA GRATISSIMA (AVOCADO) OIL 12I - Skin Fresheners 2 PERSEA GRATISSIMA (AVOCADO) OIL 12J - Other Skin Care Preps 46 PERSEA GRATISSIMA (AVOCADO) OIL 13A - Suntan Gels, Creams, and Liquids 5 PERSEA GRATISSIMA (AVOCADO) OIL 13B - Indoor Tanning Preparations 8 PERSEA GRATISSIMA (AVOCADO) OIL 13C - Other Suntan Preparations 3

TRITICUM VULGARE (WHEAT) GERM OIL 01A - Baby Shampoos 1 TRITICUM VULGARE (WHEAT) GERM OIL 01B - Baby Lotions, Oils, Powders, and Creams 6 TRITICUM VULGARE (WHEAT) GERM OIL 01C - Other Baby Products 2 TRITICUM VULGARE (WHEAT) GERM OIL 02A - Bath Oils, Tablets, and Salts 1

CIR Panel Book Page 91 2010 FDA VCRP Raw Data

TRITICUM VULGARE (WHEAT) GERM OIL 02D - Other Bath Preparations 1 TRITICUM VULGARE (WHEAT) GERM OIL 03C - Eye Shadow 1 TRITICUM VULGARE (WHEAT) GERM OIL 03D - Eye Lotion 5 TRITICUM VULGARE (WHEAT) GERM OIL 03E - Eye Makeup Remover 1 TRITICUM VULGARE (WHEAT) GERM OIL 03F - Mascara 3 TRITICUM VULGARE (WHEAT) GERM OIL 03G - Other Eye Makeup Preparations 2 TRITICUM VULGARE (WHEAT) GERM OIL 04E - Other Fragrance Preparation 2 TRITICUM VULGARE (WHEAT) GERM OIL 05A - Hair Conditioner 48 TRITICUM VULGARE (WHEAT) GERM OIL 05B - Hair Spray (aerosol fixatives) 4 TRITICUM VULGARE (WHEAT) GERM OIL 05C - Hair Straighteners 3 TRITICUM VULGARE (WHEAT) GERM OIL 05F - Shampoos (non-coloring) 30 TRITICUM VULGARE (WHEAT) GERM OIL 05G - Tonics, Dressings, and Other Hair Grooming Aids 30 TRITICUM VULGARE (WHEAT) GERM OIL 05H - Wave Sets 1 TRITICUM VULGARE (WHEAT) GERM OIL 05I - Other Hair Preparations 25 TRITICUM VULGARE (WHEAT) GERM OIL 06A - Hair Dyes and Colors (all types requiring caution statements and patch tests)9 TRITICUM VULGARE (WHEAT) GERM OIL 06D - Hair Shampoos (coloring) 1 TRITICUM VULGARE (WHEAT) GERM OIL 06F - Hair Lighteners with Color 3 TRITICUM VULGARE (WHEAT) GERM OIL 06G - Hair Bleaches 6 TRITICUM VULGARE (WHEAT) GERM OIL 06H - Other Hair Coloring Preparation 1 TRITICUM VULGARE (WHEAT) GERM OIL 07C - Foundations 1 TRITICUM VULGARE (WHEAT) GERM OIL 07E - Lipstick 29 TRITICUM VULGARE (WHEAT) GERM OIL 07I - Other Makeup Preparations 5 TRITICUM VULGARE (WHEAT) GERM OIL 08B - Cuticle Softeners 1 TRITICUM VULGARE (WHEAT) GERM OIL 08C - Nail Creams and Lotions 1 TRITICUM VULGARE (WHEAT) GERM OIL 10A - Bath Soaps and Detergents 16 TRITICUM VULGARE (WHEAT) GERM OIL 10E - Other Personal Cleanliness Products 6 TRITICUM VULGARE (WHEAT) GERM OIL 11A - Aftershave Lotion 1 TRITICUM VULGARE (WHEAT) GERM OIL 12A - Cleansing 19 TRITICUM VULGARE (WHEAT) GERM OIL 12C - Face and Neck (exc shave) 42 TRITICUM VULGARE (WHEAT) GERM OIL 12D - Body and Hand (exc shave) 78 TRITICUM VULGARE (WHEAT) GERM OIL 12F - Moisturizing 75 TRITICUM VULGARE (WHEAT) GERM OIL 12G - Night 15 TRITICUM VULGARE (WHEAT) GERM OIL 12H - Paste Masks (mud packs) 7 TRITICUM VULGARE (WHEAT) GERM OIL 12J - Other Skin Care Preps 39 TRITICUM VULGARE (WHEAT) GERM OIL 13A - Suntan Gels, Creams, and Liquids 2 TRITICUM VULGARE (WHEAT) GERM OIL 13B - Indoor Tanning Preparations 1 TRITICUM VULGARE (WHEAT) GERM OIL 13C - Other Suntan Preparations 3

CIR Panel Book Page 92 PersonalCareProducts Council Committedto Safety, Quality& Innovation Memorandum

TO: F. Alan Andersen, Ph.D. Director - COSMETIC INGREDIENT REVIEW (CW)

FROM: CIR Science and Support Committee

DATE: May 13, 2010

SUBJECT: Concentration of Use Plant Oils March 2010 Survey

Concentration of Use Vegetable Oil and Hydrogenated Vegetable Oil

Concentration of Use Major Plant Seed Oils March 2010 Survey

Concentration of Use Minor Plant Seed Oils March 2010 Survey

1101 17th Street, N.W., Suite 3O0 Washington, D.C. 20036-4702 202.331.1770 202.331 .1969 (fax) www.personcilcarecouncil.org

CIR Panel Book Page 93 Concentration of Use - Vegetable Oil and Hydrogenated Vegetable Oil

Ingredient Product Category Concentration of Use

Vegetable Oil Bath oils, tablets and salts 0002-0.02%

Vegetable Oil Eyebrow pencil 0.02-0.05%

Vegetable Oil Eye shadow 0.01-11%

Vegetable Oil Eye lotion 0.05-2%

Vegetable Oil Mascara 2%

Vegetable Oil Perfumes 0.0005-0.02%

Vegetable Oil Hair conditioners 2%

Vegetable Oil Pennanent waves 0.02%

Vegetable Oil Tonics, dressings and other hair grooming aids 0.07%

Vegetable Oil Other hair preparations (noncoloring) 0.02%

Vegetable Oil Foundations 0.04-5%

Vegetable Oil Lipstick 0.03-11%

Vegetable Oil Other makeup preparations 0.005-0.09%

Vegetable Oil Cuticle softeners 2%

Vegetable Oil Bath soaps and detergents 0.03-2%

Vegetable Oil Skin cleansing (cold creams, cleansing lotions, 0.1% liquids and pads)

Vegetable Oil Depilatories 31%

Vegetable Oil Face and neck creams, lotions and powders 0.3-2%

Vegetable Oil Body and hand creams, lotions and powders 0.2-5%

Vegetable Oil Moisturizing creams, lotions and powders 0.05%

Vegetable Oil Night creams, lotions and powders 0.05-2%

Vegetable Oil Other skin care preparations 0.0005-8%

Vegetable Oil Other suntan preparations 0.03-1%

Hydrogenated Vegetable Oil Other bath preparations 0.5%

Hydrogenated Vegetable Oil Eyebrow pencil 7-31%

Hydrogenated Vegetable Oil Eyeliner 10-49%

Hydrogenated Vegetable Oil Eye shadow 0.4-25%

Hydrogenated Vegetable Oil Eye lotion 0.2-1 1%

Hydrogenated Vegetable Oil Mascara 0.008-8%

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CIR Panel Book Page 94 Hydrogenated Vegetable Oil Hair conditioners 0.0007%

Hydrogenated Vegetable Oil Shampoos (noncoloring) 0.0005%

Hyclrogenated Vegetable Oil Tonics, dressings and other hair grooming aids 0.09%

Hydrogenated Vegetable Oil Hair dyes and colors (all types requiring 0.0004% caution statement and patch test)

Hydrogenated Vegetable Oil Hair tints 1%

Hydrogenated Vegetable Oil Blushers (all types) 2-6%

Hydrogenated Vegetable Oil Face powders 1%

Hydrogenated Vegetable Oil Foundations 0.2-57%

Hydrogenated Vegetable Oil Lipstick 0.8-60%

Hydrogenated Vegetable Oil Other makeup preparations 0.02-31%

Hydrogenated Vegetable Oil Cuticle softeners 0.2%

Hydrogenated Vegetable Oil Bath soaps and detergents 2%

Hydrogenated Vegetable Oil Other personal cleanliness products 4%

Hydrogenated Vegetable Oil Shaving cream (aerosol, brushless and lather) 0.002%

Hydrogenated Vegetable Oil Skin cleansing (cold creams, cleansing lotions 8% liquids and pads)

Hydrogenated Vegetable Oil Depilatories 6%

Hydrogenated Vegetable Oil Face and neck cream, lotions and powders 3-20%

Hydrogenated Vegetable Oil Body and hand creams, lotions and powders 0.01-14%

Hydrogenated Vegetable Oil Foot powders and sprays 3%

Hydrogenated Vegetable Oil Night creams, lotions and powders 0.0005-0.2%

Hydrogenated Vegetable Oil Paste masks (mud packs) 8%

Hydrogenated Vegetable Oil Other skin care preparations 2-8%

Hydrogenated Vegetable Oil Suntan gels, creams and liquids 3%

Hydrogenated Vegetable Oil Other suntan preparations 12% Information collected in 2010 Table prepared May 12, 2010

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CIR Panel Book Page 95 Concentration of Use Major Plant Seed Oils March 2010 Survey Brassica Campestris (Rapeseed) Seed Oil, Brassica Campestris (Rapeseed) Oil Unsaponifiables, Hydrogenated Rapeseed Oil, Potassium Rapessedate, Rapeseed Acid, Sodium Rapseedate, Canola Oil, Canola Oil Unsaponifables, Hydrogenated Canola Oil, Glycine Soja (Soybean) Oil, Glycine Soja (Soybean) Oil Unsaponifiables, Hydrogenated Soybean Oil, Soy Acid, Potassium Sovate, Sodium Soyate. Hetianthus Annuus (Sunflower) Seed Oil, Helianthus Annuns (Sunflower) Seed Oil Unsaponifiables, Hydrogenated Sunflower Seed Oil, Sunflower Seed Acid, Olea Europaea (Olive) Fruit Oil, Olea Europaea (Olive) Oil Unsaponifiables, Hydrogenated Olive Oil, 1-lydrogenated Olive Oil Unsaponifiables, Olive Acid, Olea Europea (Olive) Husk Oil, Olea Europeae (Olive) Oil Unsaponifiables, Potassium Olivate, Sodium Olivate*

Ingredient Product Category Concentration of Use

Brassica Campestris (Rapeseed) Oil Shampoos (noncoloring) 0.1%

Brassica Campestris (Rapeseed) Oil Lipstick 9%

Brassica Campestris (Rapeseed) Oil Preshave lotions (all types) 1%

Brassica Campestris (Rapeseed) Oil Skin cleansing (cold creams, cleansing lotions, 0.01-10% liquids and pads)

Brassica Campestris (Rapeseed) Oil Face and neck creams, lotions, and powders 2-17%

Brassica Campestris (Rapeseed) Oil Body and hand creams, lotions, and powders 0.0 1-9%

Brassica Campestris (Rapeseed) Oil Moisturizing crams, lotions and powders 3%

Brassica Campestris (Rapeseed) Oil Night creams, lotions and powders 3%

Brassica Campestris (Rapeseed) Oil Paste masks (mud packs) 1%

Brassica Campestris (Rapeseed) Oil Other skin care preparations 0.07%

Brassica Campestris (Rapeseed) Oil Other suntan preparations 0,007%

Hydrogenated Rapeseed Oil Mascara 2%

Hydrogenated Rapeseed Oil Foundations 0.3%

Hydrogenated Rapeseed Oil Skin cleansing (cold creams, cleansing lotions, 4% liquids and pads)

Hydrogenated Rapeseed Oil Other skin care preparations 0.8%

Canola Oil Bath oils, tablets, and salts 1-33%

Canola Oil Eye shadow 0.03%

Canola Oil Eye lotion 0.002%

Canola Oil Colognes and toilet waters 0.02%

Canola Oil Perfumes 17%

Canola Oil Other fragrance preparations 0.0002%

Canola Oil Hair conditioners 0.9-24%

Canola Oil Hair sprays (aerosol fixatives) 0.006%

Canola Oil Shampoos (noncoloring) 0.06%

Canola Oil Tonics, dressings, and other hair grooming aids 0.1-1 1%

Page 1 of 9

CIR Panel Book Page 96 Canola Oil Foundations 0.02%

Canola Oil Lipstick 0.3-70%

Canola Oil Nail clealus and lutiuns

Canola Oil Bath soaps and detergents 02-1%

Canola Oil Other personal cleanliness products 0.02%

Canola Oil Skin cleansing (cold creams, cleansing lotions, 2% liquids and pads)

Canola Oil Depilatories 002-0.06%

Canola Oil Face and neck creams, lotions, and powders 1-5%

Canola Oil Body and hand creams, lotions, and powders 28-73%

Canola Oil Paste masks (mud packs) 3%

Canola Oil Other skin care preparations 0.03-5%

Canola Oil Other suntan preparations 0.09%

Canola Oil Unsaponifiables Hair conditioners 0.00 1%

Canola Oil Unsaponifiables Shampoos (noncoloring) 0.001%

Glycine Soja (Soybean) Oil Baby lotions, oils, powders and creams 2%

Glycine Soja (Soybean) Oil Bath oils, tablets, and salts 0,1-78%

Glycine Soja (Soybean) Oil Eyebrow pencil 0.1-1%

Glycine Soja (Soybean) Oil Eyeliner 0.1-1%

Glycine Soja (Soybean) Oil Eye shadow 0.005-0.8%

Glycine Soja (Soybean) Oil Eye lotion 0.2-2%

Glycine Soja (Soybean) Oil Mascara 0.04 - 2%

Glycine Soja (Soybean) Oil Perfumes 0.03-0.5%

Glycine Soja (Soybean) Oil Other fragrance preparations 0.04%

Glycine Soja (Soybean) Oil Hair conditioners 0.0002-30%

Glycine Soja (Soybean) Oil Permanent waves 95%

Glycine Soja (Soybean) Oil Rinses (noncoloring) 0.02%

Glycine Soja (Soybean) Oil Shampoos (noncoloring) 0.0 1-0.2%

Glycine Soja (Soybean) Oil Tonics, dressings, and other hair grooming aids 0.2-66%

Glycine Soja (Soybean) Oil Blushers (all types) 0.005-0.7%

Glycine Soja (Soybean) Oil Face powders 0.005%

Glycine Soja (Soybean) Oil Foundations 0.0 1-1%

Page 2 of 9

CIR Panel Book Page 97 Glycine Soja (Soybean) Oil Leg and body paints 0.3%

Glycine Soja (Soybean) Oil Lipstick 0.06-4%

Glycine Soja (S%heaa) Oil NIakeup has 0.0

Glycine Soja (Soybean) Oil Nail creams and lotions 2-95%

Glycine Soja (Soybean) Oil Nail polish and enamel 0.02%

Glycine Soja (Soybean) Oil Nail polish and enamel removers 0.02%

Glycine Soja (Soybean) Oil Bath soaps and detergents 0.0 1-52%

Glycine Soja (Soybean) Oil Deodorants (underarm) 0.0 1-0.5%

Glycine Soja (Soybean) Oil Preshave lotions (all types) 8%

Glycine Soja (Soybean) Oil Other shaving preparations 93%

Glycine Soja (Soybean) Oil Skin cleansing (cold creams, cleansing lotions, 0.2-9% liquids and pads)

Glycine Soja (Soybean) Oil Depilatories 0.5%

Glycine Soja (Soybean) Oil Face and neck creams, lotions, and powders 0.0005-4%

Glycine Soja (Soybean) Oil Body and hand creams, lotions, and powders 0.1-75%

Glycine Soja (Soybean) Oil Foot powders and sprays 0.05%

Glycine Soja (Soybean) Oil Moisturizing creams, lotions and powders 0.1-94%

Glycine Soja (Soybean) Oil Night creams, lotions and powders 0.008-4%

Glycine Soja (Soybean) Oil Paste masks (mud packs) 0.008-1%

Glycine Soja (Soybean) Oil Other skin care preparations 0.04-49%

Glycine Soja (Soybean) Oil Suntan gels, creams, and liquids 1%

Glycine Soja (Soybean) Oil Indoor tanning preparations 1%

Glycine Soja (Soybean) Oil Other suntan preparations 0.2-0.3%

Glycine Soja (Soybean) Oil Foundations 0.03-0.1% Unsaponifiables

Glycine Soja (Soybean) Oil Face and neck creams, lotions, and powders 0,2% Unsaponifiables

Glycine Soja (Soybean) Oil Moisturizing creams, lotions and powders 0.0001% Unsaponifiables

Hydrogenated Soybean Oil Bath oils, tablets and salts 42%

Hydrogenated Soybean Oil Bubble baths 5%

Hydrogenated Soybean Oil Eyebrow pencil 7%

Hydrogenated Soybean Oil Eyeliner 5%

Page 3 of 9

CIR Panel Book Page 98 Hydrogenated Soybean Oil Eye shadow 0.03-2%

Hydrogenated Soybean Oil Hair conditioners 0.1%

HydrogcLttcl Soybcati Oil Bliislicrs (all ps) I 1

Hydrogenated Soybean Oil Face powders 0.07%

Hydrogenated Soybean Oil Foundations 0.09-15%

Hydrogenated Soybean Oil Lipstick 0.1-39%

Hydrogenated Soybean Oil Makeup bases 4%

Hydrogenated Soybean Oil Other makeup preparations 0.01%

Hydrogenated Soybean Oil Basecoats and undercoats (manicuring preparations) 0.001%

Hydrogenated Soybean Oil Cuticle softeners 0.05-2%

Hydrogenated Soybean Oil Nail creams and lotions 25%

Hydrogenated Soybean Oil Nail polish and enamel 0.00 1-2%

Hydrogenated Soybean Oil Bath soaps and detergents 0.05%

Hydrogenated Soybean Oil Other personal cleanliness products 6%

Hydrogenated Soybean Oil Skin cleansing (cold creams, cleansing lotions, 0.2-15% liquids and pads)

Hydrogenated Soybean Oil Depilatories 0.1%

Hydrogenated Soybean Oil Face and neck creams, lotions, and powders 2%

Hydrogenated Soybean Oil Body and hand creams, lotions, and powders 0.1-5%

Hydrogenated Soybean Oil Moisturizing creams, lotions and powders 0.4-5%

Hydrogenated Soybean Oil Night creams, lotions and powders 0.5-0.8%

Hydrogenated Soybean Oil Paste masks (mud packs) 7%

Hydrogenated Soybean Oil Other skin care preparations 4-21%

Hydrogenated Soybean Oil Indoor tanning preparations 1-2%

Hydrogenated Soybean Oil Other suntan preparations 0.5%

Helianthus Annuus (Sunflower) Seed Oil Other baby products 0.2%

Helianthus Annuus (Sunflower) Seed Oil Bath oils, tablets, and salts 0.05-75%

Helianthus Annuus (Sunflower) Seed Oil Bubble baths 0.2%

Helianthus Annuus (Sunflower) Seed Oil Eyebrow pencil 0.1%

Helianthus Annuus (Sunflower) Seed Oil Eyeliner 0.01-19%

Helianthus Annuus (Sunflower) Seed Oil Eye Shadow 0.002-0.3%

Helianthus Annuus (Sunflower) Seed Oil Eye lotion 0.0 1-5%

Page 4 of 9

CIR Panel Book Page 99 Helianthus Annuus (Sunflower) Seed Oil Eye makeup remover 0.0005-2%

Helianthus Annuus (Sunflower) Seed Oil Mascara 0.1%

1—lelianiluisAiinuns (Suniio\ver) Seed Oil Colngnns and oi Lt waters 0.027

Helianthus Annuus (Sunflower) Seed Oil Perfumes 0.03%

Helianthus Annuus (Sunflower) Seed Oil Other fragrance preparations 0.1-85%

Helianthus Annuus (Sunflower) Seed Oil Hair conditioners 0.000007-92%

Helianthus Annuus (Sunflower) Seed Oil Hair sprays (aerosol fixatives) 0.06-0.07%

Helianthus Annuus (Sunflower) Seed Oil Rinses (noncoloring) 0.1%

Helianthus Annuus (Sunflower) Seed Oil Shampoos (noncoloring) 0.00007- 0.3%

Helianthus Annuus (Sunflower) Seed Oil Tonics, dressings, and other hair grooming aids 0.1-83%

Helianthus Annuus (Sunflower) Seed Oil Other hair preparations (noncoloring) 0.3-15%

Helianthus Annuus (Sunflower) Seed Oil Hair dyes and colors 0.8%

Helianthus Annuus (Sunflower) Seed Oil Hair tints 20-35%

Helianthus Annuus (Sunflower) Seed Oil Hair bleaches 0.03%

Helianthus Annuus (Sunflower) Seed Oil Other hair coloring preparations 2%

Helianthus Annuus (Sunflower) Seed Oil Blushers (all types) 0.1-10%

Helianthus Annuus (Sunflower) Seed Oil Face powders 0.0 1-0.5%

Helianthus Annuus (Sunflower) Seed Oil Foundations 0.1-16%

Helianthus Annuus (Sunflower) Seed Oil Lipstick 0.08-41%

Helianthus Annuus (Sunflower) Seed Oil Makeup bases 0.1%

Helianthus Annuus (Sunflower) Seed Oil Other makeup preparations 2%

Helianthus Annuus (Sunflower) Seed Oil Cuticle softeners 30%

Helianthus Annuus (Sunflower) Seed Oil Nail polish and enamel removers 0.05%

Helianthus Annuus (Sunflower) Seed Oil Other manicuring preparations 0.4%

Helianthus Annuus (Sunflower) Seed Oil Bath soaps and detergents 0.003-10%

Helianthus Annuus (Sunflower) Seed Oil Deodorants (underarm) 0.0003-4%

Helianthus Annuus (Sunflower) Seed Oil Other personal cleanliness products 0.02-6%

Helianthus Annuus (Sunflower) Seed Oil Preshave lotions (all types) 0.2%

Helianthus Annuus (Sunflower) Seed Oil Shaving cream (aerosol, brushless, and lather) 0.1-0.5%

Helianthus Annuus (Sunflower) Seed Oil Skin cleansing (cold creams, cleansing lotions, 0.03-35% liquids and pads)

Helianthus Annuus (Sunflower) Seed Oil Depilatories 0.07-2%

Page 5 of 9

CIR Panel Book Page 100 Helianthus Annuus (Sunflower) Seed Oil Face and neck creams, lotions, and powders 0.0 1-28%

Helianthus Annuus (Sunflower) Seed Oil Body and hand creams, lotions, and powders 0.00 1-96%

1-lelianthus .•\niuus (Sunflower) Seed OP Bud’ and hand sprays 00002—I%

Helianthus Annuus (Sunflower) Seed Oil Moisturizing creams, lotions and powders 0.1-3%

Helianthus Annuus (Sunflower) Seed Oil Night creams, lotions and powders 0.05-48%

Helianthus Annuus (Sunflower) Seed Oil Paste masks (mud packs) 0.3-16%

Helianthus Annuus (Sunflower) Seed Oil Skin fresheners 0.1%

Helianthus Annuus (Sunflower) Seed Oil Other skin care preparations 0.02-80%

Helianthus Annuus (Sunflower) Seed Oil Suntan gels, creams, and liquids 1-23%

Helianthus Annuus (Sunflower) Seed Oil Indoor tanning preparations 0.002%

Helianthus Annuus (Sunflower) Seed Oil Other suntan preparations 0.1%

Helianthus Annuus (Sunflower) Seed Eyeliner 0.02% Unsaponifiables

Helianthus Annuus (Sunflower) Seed Blushers (all types) 0.1% Unsaponifiables

Helianthus Annuus (Sunflower) Seed Other personal cleanliness products 0.02% Unsaponifiables

Helianthus Annuus (Sunflower) Seed Face and neck creams, lotions, and powders 2% Unsaponifiables

Helianthus Annuus (Sunflower) Seed Body and hand creams, lotions, and powders 0.02% Unsaponifiables

Helianthus Annuus (Sunflower) Seed Night creams, lotions and powders 0.01-2% Unsaponifiables

Helianthus Annuus (Sunflower) Seed Other skin care preparations 0.005% Unsaponifiables

Hydrogenated Sunflower Seed Oil Eyeliner 7%

Hydrogenated Sunflower Seed Oil Hair tints 15-35%

Hydrogenated Sunflower Seed Oil Lipstick 6%

Hydrogenated Sunflower Seed Oil Skin cleansing (cold creams, cleansing lotions, 15-35% liquids and pads)

Olea Europaea (Olive) Fruit Oil Baby lotions, oils, powders and creams 0.2%

Olea Europaea (Olive) Fruit Oil Bath oils, tablets, and salts 2%

Olea Europaea (Olive) Fruit Oil Bubble baths 0.9%

Olea Europaea (Olive) Fruit Oil Other bath preparations 17%

Page 6 of 9

CIR Panel Book Page 101 Olea Europaea (Olive) Fruit Oil Eyeliner 0.1-17%

Olea Europaea (Olive) Fruit Oil Eye shadow 0.1-2%

Olca Eur parI (Olive) Fruit Oil E. lotion 1-3%

Olea Europaea (Olive) Frut Oil Eye makeup remover 0.0 1-10%

Olea Europaea (Olive) Fruit Oil Mascara 0.004-0.8%

Olea Europaea (Olive) Fruit Oil Perfumes 0.2-5%

Olea Europaea (Olive) Fruit Oil Hair conditioners 0.03-94%

Olea Europaea (Olive) Fruit Oil Hair sprays (aerosol fixatives) 3%

Olea Europaea (Olive) Fruit Oil Hair straighteners 0.01-0.5%

Olea Europaea (Olive) Fruit Oil Rinses (noncoloring) 0.01%

Olea Europaea (Olive) Fruit Oil Shampoos (noncoloring) 0.006-0.5%

Olea Europaea (Olive) Fruit Oil Tonics, dressings, arid other hair grooming aids 0.01-15%

Olea Europaea (Olive) Fruit Oil Other hair preparations (noncoloring) 1%

Olea Europaea (Olive) Fruit Oil Hair dyes and colors (all types requiring caution 0.2% statement and patch test)

Olea Europaea (Olive) Fruit Oil Hair bleaches 0.2%

Olea Europaea (Olive) Fruit Oil Other hair coloring preparations 0.5%

Olea Europaea (Olive) Fruit Oil Blushers (all types) 0.1-26%

Olea Europaea (Olive) Fruit Oil Face powders 0.08-2%

Olea Europaea (Olive) Fruit Oil Foundations 0.1-44%

Olea Europaea (Olive) Fruit Oil Leg and body paints 32%

Olea Europaea (Olive) Fruit Oil Lipstick 0.7-26%

Olea Europaea (Olive) Fruit Oil Makeup bases 49%

Olea Europaea (Olive) Fruit Oil Rouges 0.5%

Olea Europaea (Olive) Fruit Oil Other makeup preparations 0.4%

Olea Europaea (Olive) Fruit Oil Basecoats and undercoats (manicuring preparations) 0.00 1%

Olea Europaea (Olive) Fruit Oil Cuticle softeners 1-2%

Olea Europaea (Olive) Fruit Oil Nail creams and lotions 3%

Olea Europaea (Olive) Fruit Oil Other manicuring preparations 40%

Olea Europaea (Olive) Fruit Oil Bath soaps and detergents 0.0005-3%

Olea Europaea (Olive) Fruit Oil Deodorants (underarm) 0.02-0.1%

Olea Europaea (Olive) Fruit Oil Other personal cleanliness products 0.00 1-0.05%

Page 7 of 9

CIR Panel Book Page 102 Olea Europaea (Olive) Fruit Oil Aftershave lotions 0.5%

Olea Europaea (Olive) Fruit Oil Shaving cream (aerosol, brushless, and lather) 0.007-0.1%

QIL’a F ropnca (Olive) Fruit Oil Skin cL’nns ing (cold creams. clennsing lotions. 0.01—10% liquids and pads)

Olea Europaea (Olive) Fruit Oil Depilatories 0.1%

Olea Europaea (Olive) Fruit Oil Face and neck creams, lotions, and powders 0.03-50%

Olea Europaea (Olive) Fruit Oil Body and hand creams, lotions, and powders 0.03-100%

Olea Europaea (Olive) Fruit Oil Foot powders and sprays 3%

Olea Europaea (Olive) Fruit Oil Moisturizing creams, lotions and powders 0.05-3%

Olea Europaea (Olive) Fruit Oil Night creams, lotions and powders 0.005-1%

Olea Europaea (Olive) Fruit Oil Paste masks (mud packs) 0.0005-3%

Olea Europaea (Olive) Fruit Oil Other skin care preparations 0.05-33%

Olea Europaea (Olive) Fruit Oil Suntan gels, creams, and liquids 0.1%

Olea Europaea (Olive) Fnut Oil Indoor tanning preparations 1%

Olea Europaea (Olive) Fruit Oil Other suntan preparations 20%

Olea Europaea (Olive) Oil Unsaponifiables Baby lotions, oils, powders and creams 0.04%

Olea Europaea (Olive) Oil Unsaponifiables Eye shadow 0.02-0.4%

Olea Europaea (Olive) Oil Unsaponifiables Eye lotion 0.3%

Olea Europaea (Olive) Oil Unsaponifiables Mascara 0.2%

Olea Europaea (Olive) Oil Unsaponifiables Other fragrance preparations 3%

Olea Europaea (Olive) Oil Unsaponifiables Hair conditioners 0.07-0.3%

Olea Europaea (Olive) Oil Unsaponifiables Shampoos (noncoloring) 0.2%

Olea Europaea (Olive) Oil Unsaponifiables Tonics, dressings, and other hair grooming aids 0.02%

Olea Europaea (Olive) Oil Unsaponifiables Foundations 2%

Olea Europaea (Olive) Oil Unsaponifiables Lipstick 0.08%

Olea Europaea (Olive) Oil Unsaponifiables Face and neck creams, lotions, and powders 0.3%

Olea Europaea (Olive) Oil Unsaponifiables Body and hand creams, lotions, and powders 0.01-0.04%

Olea Europaea (Olive) Oil Unsaponiflables Moisturizing creams, lotions and powders 0.0001%

Hydrogenated Olive Oil Baby lotions, oils, powders and creams 0.4%

Hydrogenated Olive Oil Eye Shadow 0.1-3%

Hydrogenated Olive Oil Eye lotion 0.1%

Hydrogenated Olive Oil Mascara 2%

Page 8 of 9

CIR Panel Book Page 103 Hydrogenated Olive Oil Hair conditioners 0.01%

Hydrogenated Olive Oil Shampoos (noncoloring) 0.1%

tld: ‘genated Olive Oil Face po\\ders 12%

Hydrogenated Olive Oil Foundations 0.1-7%

Hydrogenated Olive Oil Lipstick 0.1-12%

Hydrogenated Olive Oil Nail creams and lotions 0.1%

Hydrogenated Olive Oil Bath soaps and detergents 0.0005%

Hydrogenated Olive Oil Face and neck creams, lotions, and powders 1-2%

Hydrogenated Olive Oil Body and hand creams, lotions, and powders 0.1-1%

Hydrogenated Olive Oil Moisturizing creams, lotions and powders 0.2%

Hydrogenated Olive Oil Night creams, lotions and powders 0.1-0.5%

Hydrogenated Olive Oil Paste masks (mud packs) 0.1%

Hydrogenated Olive Oil Other skin care preparations 1%

Hydrogenated Olive Oil Indoor tanning preparations 0.1%

Hydrogenated Olive Oil Other suntan preparations 0.1%

Hydrogenated Olive Oil Unsaponifiables Eye shadow 2%

Hydrogenated Olive Oil Unsaponifiables Eye lotion 0.3%

Hydrogenated Olive Oil Unsaponifiables Foundations 0.05-3%

Hydrogenated Olive Oil Unsaponifiables Skin cleansing (cold creams, cleansing lotions, 5% liquids and pads)

Hydrogenated Olive Oil Unsaponifiables Face and neck creams, lotions, and powders 3%

Hydrogenated Olive Oil Unsaponifiables Body and hand creams, lotions, and powders 2%

Hydrogenated Olive Oil Unsaponifiables Night creams, lotions and powders 2%

Sodium Olivate Bath soaps and detergents 4-18% *Ingredients included in the title of the table, but not found in the table were included in the survey, but no uses were reported Information collected in 2010 Table prepared May 13, 2010

The following ingredients will be included in a later concentration of use survey: Hydrogenated Safflower Oil, Potassium Safflowerate, Safflower Acid, Sodium Safflowerate, Elaeis Guineensis (Palm)Oil, Elaeis Guineensis (Palm) Kernel Oil, Hydrogenated Palm Oil, Hydrogenated Palm Kernel Oil, Palm Kernel Acid, Elaeis Guineensis (Palm) Butter, Elaeis Oleifera Kernel Oil, Elaies (Palm) Oil, Palm Acid, Hydrogenated Palm Acid, Potassium Palmate, Potassium Hydrogentaed Pamlate, Potassium Hydrogenated Palmate, Potassium Palm Kernelate, Sodium Hydrogenated Palmate, Sodium Palmate, Sodium Palm Kernelate, Gossypium Herbaceum (Cotton) Seed Oil, Cottonseed Acid, Hydrogenated Cottonseed Oil, Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Hydrogenated Rice Bran Oil, Oryza Sativa (Rice) Seed Oil, Sesamum Indicum (Sesame) Seed Butter

Page 9 of 9

CIR Panel Book Page 104 Concentration of Use Minor Plant Seed Oils Mach 2010 Survey Actinidia Chinensis (Kiwi) Seed Oil, Adansonia Digitata Oil, Adansonia Digitata Seed Oil, Hydrogenated Adansonia Digitata Seed Oil, Amaranthus Hypochondriacus Seed Oil, Arctium Lappa Seed Oil, Argania Spinosa Kernel Oil, Hydrogenated Argania Spinosa Kernel Oil, Astrocarym Murumuru Seed Butter, Sodium Astrocaryum Murumuruate, Avena Sativa (Oat) Kernel Oil, Borago Officinalis Seed Oil, Brassica Oleracea Italica (Broccoli) Seed Oil, Camelina Sativa Seed Oil, Hydrogenated Camelina Sativa Seed Oil, Camellia Oleifera Seed Oil, Hydrogenated Camellia Oleifera Seed Oil, Camellia Sinensis Seed Oil, Carica Papaya Seed Oil, Caryocar Brasiliense Fruit Oil, Chenopodium Quinoa Seed Oil, Citrullus Lanatus (Watermelon) Seed Oil, Citrus Aurantifolia (Lime) Seed Oil, Hydrogenated Lime Seed Oil, Hydrogenated Lime Seed Oil Unsaponifiables, Citrus Aurantium Dulcis (Orange) Seed Oil, Citrus Aurantium Dulcis (Orange) Seed Oil Unsaponifiables, Hydrogenated Orange Seed Oil, Hydrogenated Orange Seed Oil Unsaponifiables, Citrus Grandis (Grapefruit) Seed Oil, Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables, Citrus Paradisi (Grapefruit) Seed Oil, Hydrogenated Grapefruit Seed Oil, Hydrogenated Grapefruit Seed Oil Unsaponifiables, Citrus Limon (Lemon) Seed Oil, Coix Lacryma-Jobi (Job’s Tears) Seed Oil, Cucumis Sativus (Cucumber) Seed Oil, Cucurbita Fepo (Pumpkin) Seed Oil, Hydrogenated Pumpkin Seed Oil, Cynara Cardunculus Seed Oil, Euterpe Oleracea Fruit Oil, Fragaria Ananassa (Strawberry) Seed Oil, Fragaria Chiloensis (Strawberry) Seed Oil, Fragaria Vesca (Strawberry) Seed Oil, Fragaria Virginiana (Strawberry) Seed Oil, Guizotia Abyssinica Seed Oil, Irvingia Gabonensis Kernel Butter, Limnanthes Alba (Meadowfoam) Seed Oil, Hydrogenated Meadowfoam Seed Oil, Linum Usitatissimum (Linseed) Oil, Linseed Acid, Mangifera Indica (Mango) Seed Oil, Mangifera Indica (Mango) Seed Butter, Sodium Mangoseedate, Moringa Oleifera Seed Oil, Moringa Pterygosperma Seed Oil, Oenothera Biennis (Evening Primrose) Oil, Hydrogenated Evening Primrose Oil, Orbignya Oleifera Seed Oil, Babassu Acid, Potassium Babassuate, Sodium Babassuate, Perilla Ocymoides Seed Oil, Prunus Armeniaca (Apricot) Kernel Oil, Hydrogenated Apricot Kernel Oil, Hydrogenated Apricot Kernel Oil Unsaponifiables, Prunus Armeniaca (Apricot) Kernel Oil Unsaponifiables, Prunus Avium (Sweet Cherry) Seed Oil, Prunus Domestica Seed Oil, Prunus Persica (Peach) Kernel Oil, Hydrogenated Peach Kernel Oil, Pyrus Malus (Apple) Seed Oil, Ribes Nigrum (Black Currant) Seed Oil, Hydrogenated Black Currant Seed Oil, Ribes Rubrum (Currant) Seed Oil, Rubus Idaeus (Raspberry) Seed Oil, Hydrogenated Raspberry Seed Oil, Sclerocarya Birrea Seed Oil, Silybum Marianum Seed Oil, Solanum Lycopersicum (Tomato) Seed Oil, Solanum Lycopersicum (Tomato) Fruit Oil, Theobroma Cacao (Cocoa) Seed Butter, Sodium Cocoa Butterate, Theobroma Grandiflorum Seed Butter, Sodium Theobromoa Grandiflorum Seedate, Torreya Nucifera Seed Oil, Vaccinum Macrocarpon (Cranberry) Seed Oil, Hydrogenated Cranberry Seed Oil, Vitis Vinifera (Grape) Seed Oil, Sodium Grapeseedate, Hydrogenated Grapeseed Oil*

Ingredient Product Category Concentration of Use

Actinidia Chinensis (Kiwi) Seed Oil Hair conditioners 0.1%

Actinidia Chinensis (Kiwi) Seed Oil Shampoos (noncoloring) 0.1%

Adansonia Digitata Oil Lipstick 0.01%

Argania Spinosa Kernel Oil Bath oils, tablets, and salts 0.05%

Argania Spinosa Kernel Oil Eyebrow pencil 0.1%

Argania Spinosa Kernel Oil Eyeliner 0.1%

Argania Spinosa Kernel Oil Eye shadow 0.2%

Argania Spinosa Kernel Oil Eye lotion 1%

Argania Spinosa Kernel Oil Mascara 0.1%

Argania Spinosa Kernel Oil Hair conditioners 1%

Argania Spinosa Kernel Oil Hair sprays (aerosol fixatives) 0.0 1%

Argania Spiriosa Kernel Oil Shampoos (noncoloring) 0.1%

Argania Spinosa Kernel Oil Hair dyes and colors (all types requiring caution statement 0.1% and patch test)

Page 1 of 15

CIR Panel Book Page 105 Argania Spinosa Kernel Oil Other hair coloring preparations 0.07%

Argariia Spinosa Kernel Oil Blushers (all types) 0.1%

Argania Spinosa Kernel Oil Lipstick 0.1-1%

Argania Spinosa Kernel Oil Nail polish and enamel 0.001-0.1%

Argania Spinosa Kernel Oil Bath soaps and detergents 0.00 1-2%

Argania Spinosa Kernel Oil Deodorants (underarm) 0.001%

Argania Spinosa Kernel Oil Other personal cleanliness products 0.5%

Argania Spinosa Kernel Oil Aftershave lotions 0.005%

Argania Spinosa Kernel Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.002% pads)

Argania Spinosa Kernel Oil Face and neck creams, lotions, and powders 0.5-3%

Argania Spinosa Kernel Oil Body and hand creams, lotions, and powders 4-10%

Argania Spinosa Kernel Oil Moisturizing creams, lotions and powders 0.04%

Argania Spinosa Kernel Oil Night creams, lotions and powders 0.04-0.1%

Argania Spinosa Kernel Oil Other skin care preparations 2-3%

Astrocaryum Murumuru Seed Butter Eyeliner 0.06%

Astrocaryum Murumum Seed Butter Eye shadow 0.2%

Astrocaryum Murumuru Seed Butter Eye lotion 0.5%

Astrocaryum Murumuru Seed Butter Hair conditioners 0.00 1-0.2%

Astrocaryum Murumuru Seed Butter Shampoos (noncoloring) 0.09%

Astrocaryum Murumuru Seed Butter Tonics, dressings, and other hair grooming aids 0.2%

Astrocaryum Murumuru Seed Butter Foundations 1%

Astrocaryum Murumuru Seed Butter Lipstick 1-7%

Astrocaryum Murumuru Seed Butter Other makeup preparations 0.001%

Astrocaryum Murumuru Seed Butter Face and neck creams, lotions, and powders 1%

Astrocaryum Murumuru Seed Butter Body and hand creams, lotions, and powders 0.1-0.2%

Astrocaryum Murumuru Seed Butter Other skin care preparations 0.2%

Astrocaryum Murumuru Seed Butter Indoor tanning preparations 0.1%

Astrocaryum Murumuru Seed Butter Other suntan preparations 0.2%

Sodium Astrocaryum Murumuruate Bath soaps and detergents 0.002%

Sodium Astrocaryum Murumuruate Other shaving preparations products 0.005%

Sodium Astrocaryum Murumuruate Skin cleansing (cold creams, cleansing lotions, liquids and 0.002% pads)

Page2of 15

CIR Panel Book Page 106 Avena Sative (Oat) Kernel Oil Baby lotions, oils, powders and creams 0.1%

Avena Sative (Oat) Kernel Oil Other baby products 0.1%

Avena Sative (Oat) Kernel Oil Eye lotion 0.2%

Avena Sative (Oat) Kernel Oil Shampoos (noncoloring) 0.1%

Avena Sative (Oat) Kernel Oil Lipstick 2%

Avena Sative (Oat) Kernel Oil Bath soaps and detergents 0.01-0.1%

Avena Sative (Oat) Kernel Oil Face and neck creams, lotions, and powders 0.5%

Avena Sative (Oat) Kernel Oil Body and hand crams, lotions, and powders 0.1-3%

Avena Sative (Oat) Kernel Oil Moisturizing creams, lotions and powders 0.1%

Avena Sative (Oat) Kernel Oil Night creams, lotions and powders 0.1-0.5%

Borago Officinalis Seed Oil Eye lotion 0.001-0.5%

Borago Officinalis Seed Oil Tonics, dressings and other hair grooming aids 0.1%

Borago Officinalis Seed Oil Lipstick 0.0 1%

Borago Officinalis Seed Oil Bath soaps and detergents 0.00 1%

Borago Officinalis Seed Oil Other personal cleanliness products 0.01%

Borago Officinalis Seed Oil Preshave lotions (all types) 0.04%

Borago Officinalis Seed Oil Shaving cream (aerosol, brushless, and lather) 0.5%

Borago Officinalis Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.1% pads)

Borago Officinalis Seed Oil Face and neck creams, lotions and powders 1%

Borago Officinalis Seed Oil Body and hand crams, lotions, and powders 0.05-1%

Borago Officinalis Seed Oil Body and hand sprays 0.1%

Borago Officinalis Seed Oil Moisturizing creams, lotions and powders 1%

Borago Officinalis Seed Oil Night creams, lotions and powders 0.5%

Borago Officinalis Seed Oil Other skin care preparations 0.5%

Borago Officinalis Seed Oil Indoor tanning preparations 0.5%

Brassica Oleracea Italica (Broccoli) Seed Hair conditioners 0.5% Oil

Brassica Oleracea Italica (Broccoli) Seed Shampoos (noncoloring) 0.00 1% Oil

Brassica Oleracea Italica (Broccoli) Seed Tonics, dressings, and other hair grooming aids 3% Oil

Camelina Sativa Seed Oil Eye lotion 0.05%

Camelina Sativa Seed Oil Hair conditioners 1%

Page 3 of 15

CIR Panel Book Page 107 Camelina Sativa Seed Oil Lipstick 0.05-0.5%

Camelina Sativa Seed Oil Skin Cleansing (cold creams, cleansing lotions, liquids 0.002% and pads)

Camelina Sativa Seed Oil Face and neck creams, lotions, and powders 0.05-1%

Camelina Sativa Seed Oil Body and hand crams, lotions, and powders 0.1-0.9%

Camelina Sativa Seed Oil Moisturizing creams, lotions and powders 0.04%

Camelina Sativa Seed Oil Night creams, lotions and powders 0.04%

Camellia Oleifera Seed Oil Bath oils, tablets, and salts 0.05%

Camellia Oleifera Seed Oil Eye lotions 2%

Camellia Oleifera Seed Oil Tonics, dressings, and other hair grooming aids 2%

Camellia Oleifera Seed Oil Blushers (all types) 1%

Camellia Oleifera Seed Oil Lipstick 3%

Camellia Oleifera Seed Oil Bath soaps and detergents 0.01-0.1%

Camellia Oleifera Seed Oil Skin Cleansing (cold creams, cleansing lotions, liquids 0.003% and pads)

Camellia Oleifera Seed Oil Body and hand crams, lotions, and powders 0.0 1-1%

Camellia Oleifera Seed Oil Moisturizing creams, lotions and powders 0.08%

Camellia Oleifera Seed Oil Night creams, lotions and powders 0.08%

Camellia Oleifera Seed Oil Other suntan preparations 0.01%

Camellia Sinensis Seed Oil Shampoos (noncoloring) 0.1%

Camellia Sinensis Seed Oil Lipstick 0.1%

Camellia Sinensis Seed Oil Bath soaps and detergents 0.1%

Camellia Sinensis Seed Oil Deodorants (underarm) 0.1%

Camellia Sinensis Seed Oil Body and hand crams, lotions, and powders 0.1%

Camellia Sinensis Seed Oil Moisturizing creams, lotions and powders 0.1%

Camellia Sinensis Seed Oil Night creams, lotions and powders 0.1%

Carica Papaya Seed Oil Moisturizing creams, lotions and powders 0.1%

Carica Papaya Seed Oil Night creams, lotions and powders 0.1%

Caryocar Brasilinese Fruit Oil Lipstick 0.2%

Caryocar Brasilinese Fruit Oil Skin Cleansing (cold creams, cleansing lotions, liquids 0.0005% and pads)

Chenopodium Quinoa Seed Oil Hair rinses (coloring) 0.3%

Citrullus Lanatus (Watermelon) Seed Oil Face and neck creams, lotions, and powders 2%

Page4of 15

CIR Panel Book Page 108 Citrus Grandis (Grapefruit) Seed Oil Hair conditioners 0.1%

Citrus Grandis (Grapefruit) Seed Oil Shampoos (noncoloring) 0.1%

Citrus Grandis (Grapefruit) Seed Oil Dentifrices (aerosol, liquid, pastes and powders) 0.1%

Citrus Grandis (Grapefruit) Seed Oil Mouthwashes and breath fresheners (liquids and sprays) 0.1%

Citrus Grandis (Grapefruit) Seed Oil Bath soaps and detergents 0.1%

Citrus Grandis (Grapefruit) Seed Oil Body and hand creams, lotions and powders 0.1%

Citrus Grandis (Grapefruit) Seed Oil Moisturizing creams, lotions and powders 0.1%

Citrus Grandis (Grapefruit) Seed Oil Night creams, lotions and powders 0.1%

Cucurbita Pepo (Pumpkin) Seed Oil Eye lotion 0.003%

Cucurbita Pepo (Pumpkin) Seed Oil Moisturizing creams, lotions and powders 0.1%

Cucurbita Pepo (Pumpkin) Seed Oil Night creams, lotions and powders 0.1%

Euterpe Oleracea Fruit Oil Bath oils, tablets, and salts 0.05%

Euterpe Oleracea Fruit Oil Eye lotion 0.5%

Euterpe Oleracea Fruit Oil Lipstick 0.002%

Euterpe Oleracea Fruit Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.00001% pads)

Euterpe Oleracea Fruit Oil Other suntan preparations 0.001%

Irvingia Gabonensis Kernel Butter Lipstick 0.003-0.3%

Irvingia Gabonensis Kernel Butter Face and neck creams, lotions, and powders 0.2-0.4%

Irvingia Gabonensis Kernel Butter Body and hand creams, lotions, and powders 0.03%

Limnanthes Alba (Meadowfoam) Seed Oil Bath oils, tablets, and salts 0.9%

Limnanthes Alba (Meadowfoam) Seed Oil Bubble baths 0.5%

Limnanthes Alba (Meadowfoam) Seed Oil Eyeliner 6-20%

Limnanthes Alba (Meadowfoam) Seed Oil Eye lotion 0.1-0.4%

Limnanthes Alba (Meadowfoam) Seed Oil Other fragrance preparations 3%

Limnanthes Alba (Meadowfoam) Seed Oil Hair conditioners 0.1-1%

Limnanthes Alba (Meadowfoam) Seed Oil Tonics, dressings, and other hair grooming aids 0.5%

Lirnnanthes Alba (Meadowfoam) Seed Oil Hair dyes and colors (all types requiring caution statement 0.2-2% and patch test)

Lininanthes Alba (Meadowfoam) Seed Oil Foundations 0.01-5%

Limnanthes Alba (Meadowfoam) Seed Oil Lipstick 0.6-26%

Lirnnanthes Alba (Meadowfoam) Seed Oil Cuticle softeners 0.5%

Limnanthes Alba (Meadowfoam) Seed Oil Bath soaps and detergents 0.01%

PageS of 15

CIR Panel Book Page 109 Linmarithes Alba (Meadowfoam) Seed Oil Other personal cleanliness products 0.6%

Linmanthes Alba (Meadowfoam) Seed Oil Shaving cream (aerosol, brushless, and lather) 0.05%

Limnanthes Alba (Meadowfoam) Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.002% pads)

Limnanthes Alba (Meadowfoam) Seed Oil Depilatories 2%

Linmanthes Alba (Meadowfoam) Seed Oil Face and neck creams, lotions, and powders 0.08-72%

Linmanthes Alba (Meadowfoam) Seed Oil Body and hand creams, lotions, and powders 0.005-27%

Limnanthes Alba (Meadowfoam) Seed Oil Body and hand sprays 0.1%

Limnanthes Alba (Meadowfoam) Seed Oil Moisturizing creams, lotions and powders 0.04- 74%

Limnanthes Alba (Meadowfoam) Seed Oil Night creams, lotions and powders 0.04-3%

Limnanthes Alba(Meadowfoam) Seed Oil Other skin care preparations 0.1-1%

Linum Usitatissimum (Linseed) Seed Oil Bath oils, tablets, and salts 0.02%

Linum Usitatissimum (Linseed) Seed Oil Bubble baths 0.2%

Linum Usitatissimum (Linseed) Seed Oil Eye lotion 0.01%

Linum Usitatissimum (Linseed) Seed Oil Mascara 10%

Linum Usitatissimum (Linseed) Seed Oil Hair conditioners 0.00 1-0.01%

Linum Usitatissimum (Linseed) Seed Oil Shampoos (noncoloring) 0.00 1-0.1%

Linum Usitatissimum (Linseed) Seed Oil Tonics, dressings, and other hair 0.01%

Linum Usitatissimum (Linseed) Seed Oil Lipstick 0.0 1%

Linum Usitatissimum (Linseed) Seed Oil Cuticle softeners 0.05%

Linum Usitatissimum (Linseed) Seed Oil Nail polish and enamel 0.002%

Linum Usitatissimum (Linseed) Seed Oil Bath soaps and detergents 0.003-0.4%

Linum Usitatissimum (Linseed) Seed Oil Deodorants (underarm) 0.05-0.1%

Linum Usitatissimum (Linseed) Seed Oil Aftershave lotions 4%

Linum Usitatissimum (Linseed) Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.01-1% pads)

Linum Usitatissimum (Linseed) Seed Oil Face and neck creams, lotions, and powders 0.0 1-0.5%

Linum Usitatissimum (Linseed) Seed Oil Body and hand creams, lotions, and powders 0.1-0.2%

Linum Usitatissimum (Linseed) Seed Oil Moisturizing creams, lotions and powders 0.01-0.1%

Linum Usitatissimum (Linseed) Seed Oil Night creams, lotions and powders 0.1%

Mangifera Indica (Mango) Seed Oil Eyeliner 5%

Mangifera Indica (Mango) Seed Oil Hair conditioners 0.2%

Mangifera Indica (Mango) Seed Oil Hair straighteners 0.05%

Page6of 15

CIR Panel Book Page 110 Mangifera Indica (Mango) Seed Oil Shampoos (noncoloring) 0.1%

Mangifera Indica (Mango) Seed Oil Tonics, dressings, and other hair grooming aids 0.01%

Mangifera Indica (Mango) Seed Oil Hair dyes and colors (all types requiring caution statement 0.05% and patch test)

Mangifera Indica (Mango) Seed Oil Lipstick 0.03-6%

Mangifera Indica (Mango) Seed Oil Bath soaps and detergents 0.1%

Mangifera Indica (Mango) Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.003-0.5% pads)

Mangifera Indica (Mango) Seed Oil Face and neck creams, lotions, and powders 0.2-3%

Mangifera Indica (Mango) Seed Oil Body and hand creams, lotions, and powders 0.1-0.9%

Mangifera Indica (Mango) Seed Oil Moisturizing creams, lotions and powders 0.08%

Mangifera Indica (Mango) Seed Oil Night creams, lotions and powders 0.08%

Mangifera Indica (Mango) Seed Oil Other skin care preparations 1%

Mangifera Indica (Mango) Seed Oil Indoor tanning preparations 0.1%

Mangifera Indica (Mango) Seed Butter Eye shadow 0.02%

Mangifera Indica (Mango) Seed Butter Hair sprays (aerosol fixatives) 0.02%

Mangifera Indica (Mango) Seed Butter Shampoos (noncoloring) 0.1-0.5%

Mangifera Indica (Mango) Seed Butter Tonics, dressings, and other hair grooming aids 0.5%

Mangifera Indica (Mango) Seed Butter Blushers (all types) 0.02%

Mangifera Indica (Mango) Seed Butter Face powders 0.02%

Mangifera Indica (Mango) Seed Butter Foundations 0.02-5%

Mangifera Indica (Mango) Seed Butter Lipstick 1-5%

Mangifera Indica (Mango) Seed Butter Makeup bases 0.0 1%

Mangifera Indica (Mango) Seed Butter Cuticle softeners 0.5%

Mangifera Indica (Mango) Seed Butter Bath soaps and detergents 0.0005-0.1%

Mangifera Indica (Mango) Seed Butter Other personal cleanliness products 0.5%

Mangifera Indica (Mango) Seed Butter Shaving cream (aerosol, brushless and lather) 0.1%

Mangifera Indica (Mango) Seed Butter Depilatories 0.05%

Mangifera Indica (Mango) Seed Butter Face and neck creams, lotions, and powders 1-3%

Mangifera Indica (Mango) Seed Butter Body and hand creams, lotions, and powders 0.1-3%

Mangifera Indica (Mango) Seed Butter Moisturizing creams, lotions and powders 0.1%

Mangifera Indica (Mango) Seed Butter Night creams, lotions and powders 0.1%

Mangifera Indica (Mango) Seed Butter Other skin care preparations 0.04-2%

Page7of 15

CIR Panel Book Page 111 Moringa Oleifera Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.0 1% pads)

Moringa Pterygosperma Seed Oil Eye lotion 3%

Moringa Pterygosperma Seed Oil Tonics, dressings, and other hair grooming aids 0.02%

Moringa Pterygosperma Seed Oil Other personal cleanliness products 0.003%

Moringa Pterygosperma Seed Oil Body and hand creams, lotions, and powders 0.004%

Oenothera Biennis (Evening Primrose) Oil Bubble baths 0.2%

Oenothera Biennis (Evening Primrose) Oil Eye lotion 0.00002-0.5%

Oenothera Biennis (Evening Primrose) Oil Eye makeup remover 0.002%

OenotheraBiennis (Evening Primrose) Oil Shampoos (noncoloring) 0.05-0.1%

Oenothera Biennis (Evening Primrose) Oil Tonics, dressings, and other hair grooming aids 0.1%

Oenothera Biennis (Evening Primrose) Oil Blushers (all types) 0.08%

Oenothera Biennis (Evening Primrose) Oil Foundations 58%

Oenothera Biennis (Evening Primrose) Oil Lipstick 0.1-15%

Oenothera Biennis (Evening Primrose) Oil Cuticle softeners 3%

Oenothera Biennis (Evening Primrose) Oil Nail creams and lotions 0.00 1-0.3%

Oenothera Biennis (Evening Primrose) Oil Nail polish and enamel 0.00 1%

Oenothera Biennis (Evening Primrose) Oil Bath soaps and detergents 0.1-0.2%

Oenothera Biennis (Evening Primrose) Oil Deodorants (underarm) 0.2%

Oenothera Biennis (Evening Primrose) Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.001-0.5% pads)

Oenothera Biennis (Evening Primrose) Oil Face and neck creams, lotions, and powders 0.08-2%

Oenothera Biennis (Evening Primrose) Oil Body and hand creams, lotions, and powders 0.1-2%

Oenothera Biennis (Evening Primrose) Oil Moisturizing creams, lotions and powders 0.04-0.1%

Oenothera Biennis (Evening Primrose) Oil Night creams, lotions and powders 0.008-3%

Oenothera Biennis (Evening Primrose) Oil Paste masks (mud packs) 0.1%

Oenothera Biennis (Evening Primrose) Oil Other skin care preparations 0.002-0.1%

Oenothera Biennis (Evening Primrose) Oil Indoor tanning preparations 0.003%

Oenothera Biennis (Evening Primrose) Oil Other suntan preparations 0.5%

Orbignya Oleifera Seed Oil Bath capsules 0.1%

Orbignya Oleifera Seed Oil Other bath preparations 0.0 1%

Orbignya Oleifera Seed Oil Eye shadow 0.5-0.6%

Orbignya Oleifera Seed Oil Hair conditioners 0.3-2%

Page8of 15

CIR Panel Book Page 112 Orbignya Oleifera Seed Oil Hair sprays (aerosol fixatives) 0.02%

Orbignya Oleifera Seed Oil Tonics, dressings, and other hair grooming aids 0.1-1%

Orbignya Oleifera Seed Oil Foundations 0.5%

Orbignya Oleifera Seed Oil Lipstick 0.001-2%

Orbignya Oleifera Seed Oil Bath soaps and detergents 27%

Orbignya Oleifera Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.05% pads)

Orbignya Oleifera Seed Oil Body and hand creams, lotions, and powders 0.005-1%

Orbignya Oleifera Seed Oil Foot powders and sprays 2%

Orbignya Oleifera Seed Oil Moisturizing creams, lotions and powders 0.1%

Orbignya Oleifera Seed Oil Night creams, lotions and powders 0.1%

Orbignya Oleifera Seed Oil Other skin care preparations 4%

Orbignya Oleifera Seed Oil Suntan gels, creams, and liquids 0.0009%

Sodium Babassuate Bath soaps and detergents 8%

Prunus Armeniaca (Apricot) Kernel Oil Baby lotions, oils, powders and creams 4%

Prunus Armeniaca (Apricot) Kernel Oil Other bath preparations 7%

Prunus Armeniaca (Apricot) Kernel Oil Eye shadow 0.002-2%

Prunus Armeniaca (Apricot) Kernel Oil Eye lotion 0.2-9%

Prunus Armeniaca (Apricot) Kernel Oil Eye makeup remover 18%

Prunus Armeniaca (Apricot) Kernel Oil Mascara 0.002-0.05%

Prunus Armeniaca (Apricot) Kernel Oil Powders (dusting and talcum) (excluding aftershave) 0.1%

Prunus Armeniaca (Apricot) Kernel Oil Other fragrance preparations 0.02-1%

Prunus Armeniaca (Apricot) Kernel Oil Hair conditioners 0.003-89%

Prunus Armeniaca (Apricot) Kernel Oil Hair sprays (aerosol fixatives) 0.0009%

Prunus Armeniaca (Apricot) Kernel Oil Hair straighteners 0.0001%

Prunus Armeniaca (Apricot) Kernel Oil Rinses (noncoloring) 0.05%

Prunus Armeniaca (Apricot) Kernel Oil Shampoos (noncoloring) 0.1-0.5%

Prunus Armeniaca (Apricot) Kernel Oil Tonics, dressings, and other hair grooming aids 0.00 1-0.1%

Prunus Armeniaca (Apricot) Kernel Oil Hair dyes and colors (all types requiring caution statement 0.1% and patch test)

Prunus Armeniaca (Apricot) Kernel Oil Blushers (all types) 0.2%

Prunus Armeniaca (Apricot) Kernel Oil Face powders 0.1-0.6%

Prunus Armeniaca (Apricot) Kernel Oil Foundations 0.1-1%

Page9of 15

CIR Panel Book Page 113 Prunus Armeniaca (Apricot) Kernel Oil Leg and body paints 0.001%

Prunus Armeniaca (Apricot) Kernel Oil Lipstick 0.00 1-5%

Prunus Armeniaca (Apricot) Kernel Oil Other makeup preparations 0.2%

Prunus Armeniaca (Apricot) Kernel Oil Basecoats and undercoats (manicuring preparations) 0.05%

Prunus Armeniaca (Apricot) Kernel Oil Cuticle softeners 0.05-5%

Prunus Armeniaca (Apricot) Kernel Oil Nail creams and lotions 2-40%

Prunus Armeniaca (Apricot) Kernel Oil Nail polish and enamel 0.05%

Prunus Armeniaca (Apricot) Kernel Oil Nail polish and enamel removers 0.002-0.01%

Prunus Armeniaca (Apricot) Kernel Oil Bath soaps and detergents 0.1-9%

Prunus Armeniaca (Apricot) Kernel Oil Deodorants (underarm) 0.003-0.1%

Prunus Armeniaca (Apricot) Kernel Oil Other personal cleanliness products 0.0 1-0.5%

Prunus Armeniaca (Apricot) Kernel Oil Aftershave lotions 0.5%

Prunus Armeniaca (Apricot) Kernel Oil Shaving cream (aerosol, brushless, and lather) 0.1%

Prunus Armeniaca (Apricot) Kernel Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.00 1-3% pads)

Prunus Armeniaca (Apricot) Kernel Oil Depilatories 0.00001-2%

Prunus Armeniaca (Apricot) Kernel Oil Face and neck creams, lotions, and powders 0.05-17%

Prunus Armeniaca (Apricot) Kernel Oil Body and hand creams, lotions, and powders 0.03-12%

Prunus Armeniaca (Apricot) Kernel Oil Moisturizing creams, lotions and powders 0.1-3%

Prunus Armeniaca (Apricot) Kernel Oil Night creams, lotions and powders 0.1-8%

Prunus Armeniaca (Apricot) Kernel Oil Paste masks (mud packs) 2%

Prunus Armeniaca (Apricot) Kernel Oil Skin fresheners 0.01%

Prunus Armeniaca (Apricot) Kernel Oil Other skin care preparations 0.0001-0.5%

Prunus Armeniaca (Apricot) Kernel Oil Suntan gels, creams, and liquids 0.0 1-0.05%

Prunus Armeniaca (Apricot) Kernel Oil Indoor tanning preparations 0.01-1%

Prunus Armeniaca (Apricot) Kernel Oil Other suntan preparations 0.0005%

Prunus Avium (Sweet) Cherry Seed Oil Bath soaps and detergents 0.0 1-0.02%

Pninus Domestica Seed Oil [Preshave lotions (all types) 0.04%

Prunus Persica (Peach) Kernel Oil Bath oils, tablets, and salts 0.1%

Prunus Persica (Peach) Kernel Oil Other bath preparations 1%

Prunus Persica (Peach) Kernel Oil Other fragrance preparations 2%

Prunus Persica (Peach) Kernel Oil Hair dyes and colors (all types requiring caution statement 0.1% and patch test)

Page lOof 15

CIR Panel Book Page 114 Prunus Persica (Peach) Kernel Oil Lipstick 0.04-22%

Prunus Persica (Peach) Kernel Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.003-6% pads)

Prunus Persica (Peach) Kernel Oil Face and neck creams, lotions, and powders 0.2-0.4%

Prunus Persica (Peach) Kernel Oil Body and hand creams, lotions, and powders 0.8-3%

Prunus Persica (Peach) Kernel Oil Moisturizing creams, lotions and powders 0.08%

Prunus Persica (Peach) Kernel Oil Night creams, lotions and powders 0.08%

Prunus Persica (Peach) Kernel Oil Other suntan preparations 0.05%

Ribes Nigrum (Black Currant) Seed Oil Eye lotion 0.08%

Ribes Nigrum (Black Currant) Seed Oil Lipstick 0.03-0.1%

Ribes Nigrum (Black Currant) Seed Oil Nail creams and lotions 0.2%

Ribes Nigrum (Black Currant) Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.05% pads)

Ribes Nigrum (Black Currant) Seed Oil Body and hand creams, lotions, and powders 0.01%.

Ribes Nigrum (Black Currant) Seed Oil Moisturizing creams, lotions and powders 0.1-0.3%

Ribes Nigrum (Black Currant) Seed Oil Night creams, lotions and powders 0.1%

Ribes Nigrum (Black Currant) Seed Oil Other skin care preparations 0.000001%

Rubus Idaeus (Raspberry) Seed Oil Face and neck creams, lotions, and powders 5%

Rubus Idaeus (Raspberry) Seed Oil Night creams, lotions and powders 0.1%

Sclerocarya Birrea Seed Oil Hair conditioners 1%

Sclerocarya Birrea Seed Oil Shampoos (noncoloring) 1%

Sclerocarya Birrea Seed Oil Body and hand creams, lotions and powders 1%

Sclerocarya Birrea Seed Oil Other skin care preparations 1%

Silybum Marianum Oil Seed Foundations [0.5%

Solanum Lycopersicum (Tomato) Fruit Eye shadow 0.0 1% Oil

Solanum Lycopersicum (Tomato) Fruit Blushers (all types) 0.0 1% Oil

Solanum Lycopersicum (Tomato) Fruit Face powders 0.05% Oil

Solanum Lycopersicum (Tomato) Fruit Lipstick 0.00 1% Oil

Solanum Lycopersicum (Tomato) Fruit Other skin care preparations 1% Oil

Theobroma Cacao (Cocoa) Seed Butter Baby lotions, oils, powders and creams 0.0 1%

Page 11 of 15

CIR Panel Book Page 115 Theobroma Cacao (Cocoa) Seed Butter Other baby products 0.0 1%

Theobroma Cacao (Cocoa) Seed Butter Bath oils, tablets and salts 0.1%

Theobroma Cacao (Cocoa) Seed Butter Other bath preparations 1%

Theobroma Cacao (Cocoa) Seed Butter Eyebrow pencil 0.02%

Theobroma Cacao (Cocoa) Seed Butter Eyeliner 0.02-9%

Theobroma Cacao (Cocoa) Seed Butter Eye lotion 0.9-4%

Theobroma Cacao (Cocoa) Seed Butter Mascara 0.0002%

Theobroma Cacao (Cocoa) Seed Butter Hair conditioners 1%

Theobroma Cacao (Cocoa) Seed Butter Hair straighteners 0.01%

Theobroma Cacao (Cocoa) Seed Butter Shampoos (noncoloring) 0.0 1-0.1%

Theobroma Cacao (Cocoa) Seed Butter Tonics, dressings and other hair grooming aids 0.1-2%

Theobroma Cacao (Cocoa) Seed Butter Hair dyes and colors (all types requiring caution statement 0.1% and patch test)

Theobroma Cacao (Cocoa) Seed Butter Blushers (all types) 0.4%

Theobroma Cacao (Cocoa) Seed Butter Foundations 0.2-2%

Theobroma Cacao (Cocoa) Seed Butter Lipstick 0.3-37%

Theobroma Cacao (Cocoa) Seed Butter Makeup bases 0.02%

Theobroma Cacao (Cocoa) Seed Butter Makeup fixatives 0.00004%

Theobroma Cacao (Cocoa) Seed Butter Other makeup preparations 9%

Theobroma Cacao (Cocoa) Seed Butter Cuticle softeners 0.1%

Theobroma Cacao (Cocoa) Seed Butter Nail creams and lotions 1%

Theobroma Cacao (Cocoa) Seed Butter Bath soaps and detergents 0.02-2%

Theobroma Cacao (Cocoa) Seed Butter Deodorants (underarm) 0.00 1-1%

Theobroma Cacao (Cocoa) Seed Butter Other personal cleanliness products 0.1%

Theobroma Cacao (Cocoa) Seed Butter Aftershave lotions 1%

Theobroma Cacao (Cocoa) Seed Butter Shaving (aerosol, brushless and lather) 0.0 1-0.1%

Theobroma Cacao (Cocoa) Seed Butter Skin cleansing (cold creams, cleansing lotions, liquids and 0.0001-1% pads)

Theobroma Cacao (Cocoa) Seed Butter Depilatories 0.05-1%

Theobroma Cacao (Cocoa) Seed Butter Face and neck creams, lotions and powders 0.08-3%

Theobroma Cacao (Cocoa) Seed Butter Body and hand creams, lotions and powders 0.000002-6%

Theobroma Cacao (Cocoa) Seed Butter Foot powders and sprays 0.4%

Theobroma Cacao (Cocoa) Seed Butter Moisturizing creams, lotions and powders 2%

Page l2of 15

CIR Panel Book Page 116 Theobroma Cacao (Cocoa) Seed Butter Night creams, lotions asd powders 2%

Theobroma Cacao (Cocoa) Seed Butter Other skin care preparations 0.1-25%

Theobroma Cacao (Cocoa) Seed Butter Suntan gels, creams and liquids 5%

Theobroma Cacao (Cocoa) Seed Butter Indoor tanning preparations 0.1-0.5%

Theobroma Cacao (Cocoa) Seed Butter Other suntan preparations 0.5%

Theobroma Grandiflorum Seed Butter Eyeliner 2%

Theobroma Grandiflorum Seed Butter Eye shadow 0.1%

Theobroma Grandiflorum Seed Butter Eye lotion 2%

Theobroma Grandiflorum Seed Butter Hair conditioners 0.001-1%

Theobroma Grandiflorum Seed Butter Shampoos (noncoloring) 0.001-0.1%

Theobroma Grandiflorum Seed Butter Tonics, dressings and other hair grooming aids 0.01%

Theobroma Grandiflorum Seed Butter Other hair preparations (noncoloring) 1%

Theobroma Grandiflorum Seed Butter Foundations 5%

Theobroma Grandiflorum Seed Butter Lipstick 7%

Theobroma Grandiflorum Seed Butter Bath soaps and detergents 0.1%

Theobroma Grandiflorum Seed Butter Deodorants (underarm) 0.1%

Theobroma Grandiflorum Seed Butter Other personal cleanliness products 0.05%

Theobroma Grandiflorum Seed Butter Aftershave lotions 0. t %

Theobroma Grandiflorum Seed Butter Shaving cream (aerosol, brushless and lather) 0.1%

Theobroma Grandiflorum Seed Butter Skin cleansing (cold creams, cleansing lotions, liquids and 0.003% pads)

Theobroma Grandiflorum Seed Butter Face and neck creams, lotions and powders 2-5%

Theobroma Grandiflorum Seed Butter Body and hand creams, lotions and powders 0.1-5%

Theobroma Grandiflorum Seed Butter Moisturizing creams, lotions and powders 0.1%

Theobroma Grandiflorum Seed Butter Night creams, lotions and powders 0.1-3%

Theobroma Grandiflorum Seed Butter Other skin care preparations 0.00005%

Vaccinium Macrocarpon (Cranberry) Seed Hair conditioners 0.1% Oil

Vaccinium Macrocarpon (Cranberry) Seed Shampoos (noncoloring) 0.0 1% Oil

Vaccinium Macrocarpon (Cranberry) Seed Tonics, dressings and other hair grooming aids 0.1% Oil

Vaccinium Macrocarpon (Cranberry) Seed Foundations 0.1% Oil

Page 13 of 15

CIR Panel Book Page 117 Vaccinium Macrocarpon (Cranberry) Seed Lipstick 0.3% Oil

Vaccinium Macrocarpon (Cranberry) Seed Other makeup preparations 0.002% Oil

Vaccinium Macrocarpon (Cranberry) Seed Bath soaps and detergents 0.003-0.1% Oil

Vaccinium Macrocarpon (Cranberry) Seed Face and neck creams, lotions and powders 2% Oil

Vaccinium Macrocarpon (Cranberry) Seed Body and hand creams, lotions and powders 0.1% Oil

Vaccinium Macrocarpon (Cranberry) Seed Moisturizing creams, lotions and powders 0.1% Oil

Vaccinium Macrocarpon (Cranberry) Seed Night creams, lotions and powders 0.1% Oil

Vitis Vinifera (Grape) Seed Oil Bath oils, tablets and salts 0.1-0.5%

Vitis Vinifera (Grape) Seed Oil Bubble baths 2%

Vitis Vinifera (Grape) Seed Oil Other bath preparations 0.01%

Vitis Vinifera (Grape) Seed Oil Eye lotion 5%

Vitis Vinifera (Grape) Seed Oil Eye makeup remover 0.01%

Vitis Vinifera (Grape) Seed Oil Perfumes 1%

Vitis Vinifera (Grape) Seed Oil Other fragrance preparations 0.00 1-7%

Vitis Vinifera (Grape) Seed Oil Hair conditioners 0.01-0.3%

Vitis Vinifera (Grape) Seed Oil Shampoos (noncoloring) 0.05-0.1%

Vitis Vinifera (Grape) Seed Oil Tonics, dressings and other hair grooming aids 0.01-0.1%

Vitis Vinifera (Grape) Seed Oil Hair dyes and colors (all types requiring caution statement 43% and patch test)

Vitis Vinifera (Grape) Seed Oil Foundations 0.2%

Vitis Vinifera (Grape) Seed Oil Lipstick 0.03-7%

Vitis Vinifera (Grape) Seed Oil Cuticle softeners 35%

Vitis Vinifera (Grape) Seed Oil Nail creams and lotions 1%

Vitis Vinifera (Grape) Seed Oil Nail polish and enamel 0.00 1%

Vitis Vinifera (Grape) Seed Oil Bath soaps and detergents 0.0 1-7%

Vitis Vinifera (Grape) Seed Oil Deodorants (underarm) 0.00 1-0.2%

Vitis Vinifera (Grape) Seed Oil Other personal cleanliness products 0.001-1%

Vitis Vinifera (Grape) Seed Oil Aftershave lotions 0.1-1%

Page l4of 15

CIR Panel Book Page 118 Vitis Vinifera (Grape) Seed Oil Preshave lotions (all types) 16-39%

Vitis Vinifera (Grape) Seed Oil Shaving cream (aerosol, brushless and lather) 2%

Vitis Vinifera (Grape) Seed Oil Other shaving preparations 0.1%

Vitis Vinifera (Grape) Seed Oil Skin cleansing (cold creams, cleansing lotions, liquids and 0.004-20% pads)

Vitis Vinifera (Grape) Seed Oil Depilatories 0.5%

Vitis Vinifera (Grape) Seed Oil Face and neck creams, lotions and powders 0.1-8%

Vitis Vinifera (Grape) Seed Oil Body and hand creams, lotions and powders 0.0141%

Vitis Vinifera (Grape) Seed Oil Body and hand sprays 1%

Vitis Vinifera (Grape) Seed Oil Moisturizing creams, lotions and powders 0.0 1-5%

Vitis Vinifera (Grape) Seed Oil Night creams, lotions and powders 0.0 1-5%

Vitis Vinifera (Grape) Seed Oil Paste masks (mud packs) 0.01%

Vitis Vinifera (Grape) Seed Oil Other skin care preparations 0.01-13%

Vitis Vinifera (Grape) Seed Oil Indoor tanning preparations 0.00 1%

Vitis Vinifera (Grape) Seed Oil Other suntan preparations 15%

Hydrogenated Grapeseed Oil Other bath preparations 0.5%

Hydrogenated Grapeseed Oil Lipstick 0.5%

Hydrogenated Grapeseed Oil Cuticle softeners 0.3% Ingredients included in the title of the table, out not found in the table were included in the survey, but no uses were reported Information collected in 2010 Table prepared May 13, 2010

The following ingredients will be included in a later concentration of use survey: Camellia Japonica Seed Oil, Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables, Persea Gratissima (Avocado) Oil, Hydrogenated Avocado Oil, Persea Gratissima (Avocado) Butter, Persea Gratissima (Avocado) Oil Unsaponifiables, Sodium Avocadoate, Triticum Vulgare (Wheat) Germ Oil, Hydrogenated Wheat Germ Oil, Hydrogenated Wheat Germ Oil Unsaponifiables, Triticum Aestivum (Wheat) Germ Oil, Triticum Vulgare (Wheat) Germ Oil Unsaponifiables and Wheat Germ Acid.

Page 15 of 15

CIR Panel Book Page 119 PersonalCare ProductsCouncil Committedto Safety, ua ify nnovafion

Memorandum

TO: F. Alan Andersen, Ph.D. Director - COSMETIC INGREDIENT REVIEW (CIR)

FROM: John Bailey, Ph.D. Industry Liaison to the CIR Expert Panel

DATE: July 12, 2010

SUBJECT: Concentration of Use Plant Oils May 2010 Use Survey

CIR Panel Book Page 120 Concentration of Use by FDA Product Category Gossypium Herbaceum (Cotton) Seed Oil, Cottonseed Acid, Hydrogenated Cottonseed Oil, Elaeis Guinennsis (Palm) Oil, Elaeis Guinennsis (Palm) Kernel Oil, Hydrogenated Palm Oil, Hydrogenated Palm Kernel Oil, Elaeis Guineensis (Palm) Butter, Elaeis Oleifera Kernel Oil, Elaeis (Palm) Oil, Hydrogenated Palm Acid, Palm Acid, Palm Kernel Acid, Potassium Palmate, Potassium Hydrogenated Palmate, Potassium Palm Kernelate, Sodium Hydrogenated Palmate, Sodium Palmate, Sodium Palm Kernelate, Hydrogenated Safflower Seed Oil, Potassium Safflowerate, Safflower Acid, Sodium Safflowerate, Sesamum Indicum (Sesame) Seed Butter, Persea Gratissima (Avocado) Oil, Hydrogenated Avocado Oil, Persea Gratissima (Avocado) Butter, Persea Gratissima (Avocado) Oil Unsaponifiables, Sodium Avocadoate, Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Hydrogenated Rice Bran Oil, Oryza Sativa (Rice) Seed Oil, Triticum Vulgare (Wheat) Germ Oil, Triticum Vulgare (Wheat) Germ Oil Unsaponifiables, Hydrogenated Wheat Germ Oil, Hydrogenated Wheat Germ Oil Unsaponifiables, Triticum Aestivum (Wheat) Germ Oil, Wheat Germ Acid, Camellia Japonica Seed Oil, Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables

Ingredient Product Category Concentration of Use

Gossypium Herbaceum (Cottonseed) Oil Eyeliner 0.1-11%

Gossypium Herbaceum (Cottonseed) Oil Eye shadow 0.1%

Gossypium Herbaceum (Cottonseed) Oil Eye lotion 0.5%

Gossypium Herbaceum (Cottonseed) Oil Foundations 0.5%

Gossypium Herbaceum (Cottonseed) Oil Lipstick 0.2-1%

Gossypium Herbaceum (Cottonseed) Oil Nail creams and lotions 30-32%

Gossypium Herbaceum (Cottonseed) Oil Other manicuring preparations 0.5%

Gossypium Herbaceum (Cottonseed) Oil Bath soaps and detergents 0.1%

Gossypium Herbaceum (Cottonseed) Oil Deodorants (underarm) 0.2%

Gossypium Herbaceum (Cottonseed) Oil Other personal cleanliness products 0.004-0.01%

Gossypium Herbaceum (Cottonseed) Oil Preshave lotions (all types) 29%

Gossypium Herbaceum (Cottonseed) Oil Shaving creams (aerosol, brushless and 1% lather)

Gossypium Herbaceum (Cottonseed) Oil Skin cleansing (cold creams, cleansing 0.5% lotions, liquids and pads)

Gossypium Herbaceum (Cottonseed) Oil Face and neck creams, lotions and powders 0.5%

Gossypium Herbaceum (Cottonseed) Oil Body and hand creams, lotions and powders 0.3-2%

Gossypium Herbaceum (Cottonseed) Oil Body and hand sprays 0.2%

Gossypium Herbaceum (Cottonseed) Oil Moisturizing creams, lotions and powders 0.08%

Gossypium Herbaceum (Cottonseed) Oil Night creams, lotions and powders 0.08-2%

Page 1 of 9

CIR Panel Book Page 121 Gossypium Herbaceum (Cottonseed) Oil Other skin care preparations 5%

Hydrogenated Cottonseed Oil Eyebrow pencil 11-24%

Hydrogenated Cottonseed Oil Eyeliner 8-15%

Hydrogenated Cottonseed Oil Mascara 0.5%

Hydrogenated Cottonseed Oil Other eye makeup preparations 8%

Hydrogenated Cottonseed Oil Hair conditioners 0.0 1%

Hydrogenated Cottonseed Oil Shampoos (noncoloring) 0.01%

Hydrogenated Cottonseed Oil Tonics, dressings and other hair grooming 0.1% aids

Hydrogenated Cottonseed Oil Foundations 5%

Hydrogenated Cottonseed Oil Lipstick 8-12%

Hydrogenated Cottonseed Oil Other makeup preparations 0.002-1 1%

Hydrogenated Cottonseed Oil Face and neck creams, lotions and powders 0.005-5%

Hydrogenated Cottonseed Oil Other skin care preparations 0.00 1%

Elaeis Guineensis (Palm) Oil Eye lotion 0.04-2%

Elaeis Guineensis (Palm) Oil Hair conditioners 2%

Elaeis Guineensis (Palm) Oil Tonics, dressings and other hair grooming 13% aids

Elaeis Guineensis (Palm) Oil Other hair preparations (noncoloring) 34%

Elaeis Guineensis (Palm) Oil Foundations 5%

Elaeis Guineensis (Palm) Oil Lipstick 2%

Elaeis Guineensis (Palm) Oil Bath soaps and detergents 48%

Elaeis Guineensis (Palm) Oil Other personal cleanliness products 0.002%

Elaeis Guineensis (Palm) Oil Aftershave lotions 0.5%

Elaeis Guineensis (Palm) Oil Skin cleansing (cold creams, cleansing 0.002-8% lotions, liquids and pads)

Elaeis Guineensis (Palm) Oil Face and neck creams, lotions and powders 0.008-4%

Elaeis Guineensis (Palm) Oil Body and hand creams, lotions and powders 4-6%

Elaeis Guineensis (Palm) Oil Moisturizing creams, lotions and powders 0.4-3%

Elaeis Guineensis (Palm) Oil Night creams, lotions and powders 3-4%

Elaeis Guineensis (Palm) Oil Paste masks (mud packs) 4-5%

Page 2 of 9

CIR Panel Book Page 122 Elaeis Guineensis (Palm) Oil Other skin care preparations 0.9-2%

Elaeis Guineensis (Palm) Kernel Oil Eye lotion 0.8%

Elaeis Guineensis (Palm) Kernel Oil Shampoos (noncoloring) 0.9-23%

Elaeis Guineensis (Palm) Kernel Oil Other manicuring preparations 3%

Elaeis Guineensis (Palm) Kernel Oil Bath soaps and detergents 0.05%

Elaeis Guineensis (Palm) Kernel Oil Shaving cream (aerosol, brushless and 0.05% lather)

Elaeis Guineensis (Palm) Kernel Oil Moisturizing creams, lotions and powders 0.8%

Elaeis Guineensis (Palm) Kernel Oil Other skin care preparations 2%

Hydrogenated Palm Oil Eyebrow pencil 3-5%

Hydrogenated Palm Oil Eyeliner 2-30%

Hydrogenated Palm Oil Eye lotion 0.9%

Hydrogenated Palm Oil Mascara 0.2%

Hydrogenated Palm Oil Colognes and toilet waters 1%

Hydrogenated Palm Oil Face powders 0.4%

Hydrogenated Palm Oil Foundations 8%

Hydrogenated Palm Oil Lipstick 2-30%

Hydrogenated Palm Oil Makeup bases 1%

Hydrogenated Palm Oil Makeup fixatives 0.5%

Hydrogenated Palm Oil Other makeup preparations 25%

Hydrogenated Palm Oil Bath soaps and detergents 2%

Hydrogenated Palm Oil Face and neck creams, lotions and powders 2%

Hydrogenated Palm Oil Body and hand creams, lotions and powders 10%

Hydrogenated Palm Oil Moisturizing creams, lotions and powders 3%

Hydrogenated Palm Oil Paste masks (mud packs) 2%

Hydrogenated Palm Oil Other skin care preparations 3%

Hydrogenated Palm Oil Suntan gels, creams and liquids 1%

Hydrogenated Palm Kernel Oil Eyebrow pencil 2%

Hydrogenated Palm Kernel Oil Eyeliner 7-10%

Hydrogenated Palm Kernel Oil Foundations 0.4%

Page 3 of 9

CIR Panel Book Page 123 -

Hydrogenated Palm Kernel Oil Lipstick 3-13%

Hydrogenated Palm Kernel Oil Bath soaps and detergents 0.9-2%

Hydrogenated Palm Kernel Oil Face and neck creams, lotions and powders 1-5%

Hydrogenated Palm Kernel Oil Body and hand creams, lotions and powders 0.6-3%

Hydrogenated Palm Kernel Oil Moisturizing creams, lotions and powders 2%

Hydrogenated Palm Kernel Oil Night creams, lotions and powders 3%

Hydrogenated Palm Kernel Oil Paste masks (mud packs) 0.6-1%

Hydrogenated Palm Kernel Oil Suntan gels, creams and liquids 0.6%

Palm Acid Bath soaps and detergents 1-4%

Palm Acid Skin cleansing (cold creams, cleansing 17% lotions, liquids and pads)

Palm Kernel Acid Bath soaps and detergents 0.2-3%

Palm Kernel Acid Skin cleansing (cold creams, cleansing 12% lotions, liquids

Potassium Palmate IBath soaps and detergents 0.3-3% Potassium Kernelate Palm IBath soaps and detergents 0.3-30% Sodium Palmate Bath soaps and detergents 3-68%

Sodium Palmate Shaving soap (cakes, sticks, etc.) 63%

Sodium Palmate Skin cleansing (cold creams, cleansing 28% lotions, liquids and pads)

Sodium Palm Kernelate Bath soaps and detergents 16-44%

Sodium Palm Kernelate Shaving soaps (cakes, sticks, etc.) 15%

Sodium Palm Kernelate Skin cleansing (cold creams, cleansing 12% lotions, liquids and pads)

Persea Gratissima (Avocado) Oil Bath oils, tablets and salts 0.6-6%

Persea Gratissima (Avocado) Oil Eyeliner 0.1-1%

Persea Gratissima (Avocado) Oil Eye shadow 0.1%

Persea Gratissima (Avocado) Oil Eye lotion 0.05-2%

Persea Gratissima (Avocado) Oil Eye makeup remover 2%

Persea Gratissima (Avocado) Oil Mascara 0.2%

Persea Gratissima (Avocado) Oil Perfumes 8%

Page 4 of 9

CIR Panel Book Page 124 Persea Gratissima (Avocado) Oil Powders (dusting and talcum) 02%

Persea Gratissima (Avocado) Oil Other fragrance preparations 1%

Persea Gratissima (Avocado) Oil Hair conditioners 0.0001-15%

Persea Gratissima (Avocado) Oil Hair sprays (aerosol fixatives) 0.05%

Persea Gratissima (Avocado) Oil Shampoos (noncoloring) 0.01-1%

Persea Gratissima (Avocado) Oil Tonics, dressings and other hair grooming 41% aids

Persea Gratissima (Avocado) Oil Hair dyes and colors (all types requiring 0.3% caution Statement and patch test)

Persea Gratissima (Avocado) Oil Hair rinses (coloring) 0.3%

Persea Gratissima (Avocado) Oil Blushers (all types) 0.2-0.5%

Persea Gratissima (Avocado) Oil Face powders 0.1-0.3%

Persea Gratissima (Avocado) Oil Foundations 0.0 1-3%

Persea Gratissima (Avocado) Oil Lipstick 0.05-26%

Persea Gratissima (Avocado) Oil Makeup bases 2%

Persea Gratissima (Avocado) Oil Other makeup preparations 0.1%

Persea Gratissima (Avocado) Oil Cuticle softeners 18-19%

Persea Gratissima (Avocado) Oil Nail creams and lotions 2-5%

Persea Gratissima (Avocado) Oil Nail polish and enamel 0.00 1%

Persea Gratissima (Avocado) Oil Other manicuring preparations 34%

Persea Gratissima (Avocado) Oil Bath soaps and detergents 0.02-0.5%

Persea Gratissima (Avocado) Oil Deodorants (underarm) 0.1%

Persea Gratissima (Avocado) Oil Other personal cleanliness products 1-3%

Persea Gratissima (Avocado) Oil Aftershave lotions 0.5%

Persea Gratissima (Avocado) Oil Preshave lotions (all types) 0.00 1%

Persea Gratissima (Avocado) Oil Shaving cream (aerosol. brushless and 0.05% lather)

Persea Gratissima (Avocado) Oil Other shaving preparations 0.8-2%

Persea Gratissima (Avocado) Oil Skin cleansing (cold creams, cleansing 0.003-3% lotions, liquids and pads)

Persea Gratissima (Avocado) Oil Depilatories 0. 1%

Page 5 of 9

CIR Panel Book Page 125 Persea Gratissima (Avocado) Oil Face and neck creams, lotions and powders 0.01-98%

Persea Gratissima (Avocado) Oil Body and hand creams, lotions and powders 0.01-6%

Persea Gratissima (Avocado) Oil Foot powders and sprays 0.0 1%

Persea Gratissima (Avocado) Oil Moisturizing creams, lotions and powders 0.1-2%

Persea Gratissima (Avocado) Oil Night creams, lotions and powders 0.02-1%

Persea Gratissima (Avocado) Oil Paste masks (mud packs) 0.3-2%

Persea Gratissima (Avocado) Oil Other skin care preparations 0.1-31%

Persea Gratissima (Avocado) Oil Suntan gels, creams and liquids 0.02-2%

Persea Gratissima (Avocado) Oil Indoor tanning preparations 0.0005-0.5%

Hydrogenated Avocado Oil Other hair preparations (noncoloring) 0.5%

Persea Gratissima (Avocado) Oil Eye shadow 0.5% Unsaponifiables

Persea Gratissima (Avocado) Oil Tonics, dressings and other hair grooming 6% Unsaponifiables aids

Persea Gratissima (Avocado) Oil Lipstick 3% Unsaponifiables

Persea Gratissima (Avocado) Oil Skin cleansing (cold creams, cleansing 0.2% Unsaponifiables lotions , liquids and pads)

Oryza Sativa (Rice) Bran Oil Bath oils, tablets and salts 0.2%

Oryza Sativa (Rice) Bran Oil Eyeliner 0.8%

Oryza Sativa (Rice) Bran Oil Eye shadow 0.5%

Oryza Sativa (Rice) Bran Oil Eye lotion 0.5-0.6%

Oryza Sativa (Rice) Bran Oil Hair conditioners 0.2-0.3%

Oryza Sativa (Rice) Bran Oil Hair sprays (aerosol fixatives) 0.1%

Oryza Sativa (Rice) Bran Oil Shampoos (noncoloring) 0.005-0.3%

Oryza Sativa (Rice) Bran Oil Tonics, dressings and other hair grooming 0.02-0.5% aids

Oryza Sativa (Rice) Bran Oil Other hair preparations (noncoloring) 0.3%

Oryza Sativa (Rice) Bran Oil Hair rinses (coloring) 0.3%

Oryza Sativa (Rice) Bran Oil Face powders 0.3%

Oryza Sativa (Rice) Bran Oil Foundations 0.1-1%

Oryza Sativa (Rice) Bran Oil Lipstick 0.1-8%

Page 6 of 9

CIR Panel Book Page 126 Oryza Sativa (Rice) Bran Oil Makeup bases 0.4%

Oryza Sativa (Rice) Bran Oil Nail creams and lotions 3-78%

Oryza Sativa (Rice) Bran Oil Nail polish and enamel 0.02%

Oryza Sativa (Rice) Bran Oil Other manicuring preparations 0.1%

Oryza Sativa (Rice) Bran Oil Bath soap and detergents 1%

Oryza Sativa (Rice) Bran Oil Deodorants (underarm) 0.5%

Oryza Sativa (Rice) Bran Oil Other personal cleanliness products 0.0006-6%

Oryza Sativa (Rice) Bran Oil Aftershave lotions 0.5%

Oryza Sativa (Rice) Bran Oil Preshave lotions (all types) 1%

Oryza Sativa (Rice) Bran Oil Skin cleansing (cold creams, cleansing 0.2-0.6% lotions, liquids and pads)

Oryza Sativa (Rice) Bran Oil Depilatories 0.5%

Oryza Sativa (Rice) Bran Oil Face and neck creams, lotions and powders 0.1-27%

Oryza Sativa (Rice) Bran Oil Body and hand creams, lotions and powders 0.5-5%

Oryza Sativa (Rice) Bran Oil Body and hand sprays 0.0003%

Oryza Sativa (Rice) Bran Oil Moisturizing creams, lotions and powders 8%

Oryza Sativa (Rice) Bran Oil Night creams, lotions and powders 4-5%

Oryza Sativa (Rice) Bran Oil Other skin care preparations 0.5-27%

Oryza Sativa (Rice) Germ Oil Bath oils, tablets and salts 3%

Oryza Sativa (Rice) Germ Oil Bubble baths 0.03%

Oryza Sativa (Rice) Germ Oil Eyebrow pencil 0.1%

Oryza Sativa (Rice) Germ Oil Eyeliner 0.1%

Oryza Sativa (Rice) Germ Oil Eye shadow 0.01%

Oryza Sativa (Rice) Germ Oil Eye makeup remover 0.01-0.1%

Oryza Sativa (Rice) Germ Oil Mascara 0.1-1%

Oryza Sativa (Rice) Germ Oil Blushers (all types) 0.1%

Oryza Sativa (Rice) Germ Oil Face powders 0.01%

Oryza Sativa (Rice) Germ Oil Foundations 0.1%

Oryza Sativa (Rice) Germ Oil Lipstick 0.1-3%

Oryza Sativa (Rice) Germ Oil Makeup bases 0.1%

Page 7 of 9

CIR Panel Book Page 127 Oryza Sativa (Rice) Germ Oil Bath soaps and detergents 0.5%

Oryza Sativa (Rice) Germ Oil Deodorants (underarm) 0.003%

Oryza Sativa (Rice) Germ Oil Other personal cleanliness products 0.003-0.005%

Oryza Sativa (Rice) Germ Oil Skin cleansing (cold creams, cleansing 0.003-0.01% lotions, liquids and pads)

Oryza Sativa (Rice) Germ Oil Face and neck creams, lotions and powders 0.2-3%

Oryza Sativa (Rice) Germ Oil Body and hand creams, lotions and powders 0.02-2%

Oryza Sativa (Rice) Germ Oil Moisturizing creams, lotions and powders 0.01-0.1%

Oryza Sativa (Rice) Germ Oil Night creams, lotions and powders 0.08%

Oryza Sativa (Rice) Germ Oil Paste masks (mud packs) 0.0 1%

Oryza Sativa (Rice) Germ Oil Other skin care preparations 0.1%

Oryza Sativa (Rice) Germ Oil Suntan gels, creams and liquids 0.01%

Triticum Vulgare (Wheat) Germ Oil Bath oils, tablets and salts 0.5%

Triticum Vulgare (Wheat) Germ Oil Eye shadow 0.02%

Triticum Vulgare (Wheat) Germ Oil Eye lotion 0.1-0.5%

Triticum Vulgare (Wheat) Germ Oil Eye makeup remover 0.01%

Triticum Vulgare (Wheat) Germ Oil Mascara 0.05-0.1%

Triticum Vulgare (Wheat) Germ Oil Hair conditioners 0.00 1-0.5%

Triticum Vulgare (Wheat) Germ Oil Hair sprays (aerosol fixatives) 0.0001-00005%

Triticum Vulgare (Wheat) Germ Oil Shampoos (noncoloring) 0.00 1-0.5%

Triticum Vulgare (Wheat) Germ Oil Tonics, dressings and other hair grooming 0.00 1-0.5% aids

Triticum Vulgare (Wheat) Germ Oil Other hair preparations (noncoloring) 0.1%

Triticum Vulgare (Wheat) Germ Oil Hair dyes and colors (all types requiring 0.0 1-0.2% caution statement and patch test)

Triticum Vulgare (Wheat) Germ Oil Face powders 0.1%

Triticum Vulgare (Wheat) Germ Oil Foundations 0.00 1-2%

Triticum Vulgare (Wheat) Germ Oil Lipstick 0.3-5%

Triticum Vulgare (Wheat) Germ Oil Makeup bases 0.1%

Triticum Vulgare (Wheat) Germ Oil Cuticle softeners 1%

Triticum Vulgare (Wheat) Germ Oil Nail creams and lotions 3%

Page 8 of 9

CIR Panel Book Page 128 Triticum Vulgare (Wheat) Germ Oil Other manicuring preparations 0.1-28%

Triticum Vulgare (Wheat) Germ Oil Bath soaps and detergents 0.0 1-0.5%

Triticum Vulgare (Wheat) Germ Oil Other personal cleanliness products 0.2%

Triticum Vulgare (Wheat) Germ Oil Skin cleansing (cold creams, cleansing 0.0 1-2% lotions , liquids and pads)

Triticum Vulgare (Wheat) Germ Oil Depilatories 0.6%

Triticum Vulgare (Wheat) Germ Oil Face and neck creams, lotions and powders 0.001-20%

Triticum Vulgare (Wheat) Germ Oil Body and hand creams, lotions and powders 0.3-1%

Triticum Vulgare (Wheat) Germ Oil Moisturizing creams, lotions and powders 0.5%

Triticum Vulgare (Wheat) Germ Oil Night creams, lotions and powders 0.08-0.5%

Triticum Vulgare (Wheat) Germ Oil Paste masks (mud packs) 2%

Triticum Vulgare (Wheat) Germ Oil Other skin care preparations 0.1-23%

Triticum Vulgare (Wheat) Germ Oil Suntan gels, creams and liquids 0.04%

Triticum Vulgare (Wheat) Germ Oil Indoor tanning preparations 0.0005%

Triticum Vulgare (Wheat) Germ Oil Face and neck creams, lotions and powders 0.2% Unsaponifiables

Triticum Aestivüm (Wheat) Germ Oil Hair conditioners <1%

Triticum Aestivum (Wheat) Germ Oil Hair straighteners <1%

Triticum Aestivum (Wheat) Germ Oil Moisturizing creams, lotions and powders <1%

Camellia Japonica Seed Oil Eye shadow 0.01%

Camellia Japonica Seed Oil Rinses (noncoloring) 0.1%

Camellia Japonica Seed Oil Blushers (all types) 0.01%

Camellia Japonica Seed Oil Lipstick 0.1%

Camellia Japonica Seed Oil Deodorants (underarm) 0.0 1%

Camellia Japonica Seed Oil Other personal cleanliness products 0.1%

Camellia Japonica Seed Oil Moisturizing creams, lotions and powders 0.2% *Ingredients included in the title of the table but not found in the table were included in the concentration of use survey, but no uses were reported. Information collected in 2010 Table prepared July 12, 2010

Page 9 of 9

CIR Panel Book Page 129 Persona’Care ProductsCouncil Committedto Safety, Quality& Innovation Memorandum

TO: F. Alan Andersen, Ph.D. Director - COSMETIC INGREDIENT REVIEW (CIR)

FROM: CIR Science and Support Committee

DATE: July2l,2010

SUBJECT: Concentration of Use Plant Oils Updated May 2010 Survey

1101 17th Street, N.W., Suite 300 Washington, D.C. 20036-4702 202.331.1770 202.331.1969 (fax) www.personalcarecouncil.org

I CIR Panel Book Page 130 Concentration of Use by FDA Product Category Gossypium Herbaceum (Cotton) Seed Oil, Cottonseed Acid, Hydrogenated Cottonseed Oil, Elaeis Guinennsis (Palm) Oil, Elaeis Guinennsis (Palm) Kernel Oil, Hydrogenated Palm Oil, Hydrogenated Palm Kernel Oil, Elaeis Guineensis (Palm) Butter, Elaeis Oleifera Kernel Oil, Elaeis (Palm) Oil, Hydrogenated Palm Acid, Palm Acid, Palm Kernel Acid, Potassium Palmate, Potassium Hydrogenated Palmate, Potassium Palm Kernelate, Sodium Hydrogenated Palmate, Sodium Palmate, Sodium Palm Kernelate, Hydrogenated Safflower Seed Oil, Potassium Safflowerate, Safflower Acid, Sodium Safflowerate, Sesamum Indicum (Sesame) Seed Butter, Persea Gratissima (Avocado) Oil, Hydrogenated Avocado Oil, Persea Gratissima (Avocado) Butter, Persea Gratissima (Avocado) Oil Unsaponifiables, Sodium Avocadoate, Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Hydrogenated Rice Bran Oil, Oryza Sativa (Rice) Seed Oil, Triticum Vulgare (Wheat) Germ Oil, Triticum Vulgare (Wheat) Germ Oil Unsaponiflables, Hydrogenated Wheat Germ Oil, Hydrogenated Wheat Germ Oil Unsaponiflables, Triticum Aestivum (Wheat) Germ Oil, Wheat Germ Acid, Camellia Japonica Seed Oil, Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables