bioRxiv preprint doi: https://doi.org/10.1101/2021.09.03.458707; this version posted September 5, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 ISL1 is an essential determinant of structural and functional tonotopic representation of 2 sound 3 4 5 Authors: Iva Filovaa, 1, Kateryna Pysanenkob,1, Mitra Tavakolia, Simona Vochyanovaa, 6 Martina Dvorakovaa, Romana Bohuslavovaa, Ondrej Smolika, Sarka Benesovac, Lukas 7 Valihrachc, Ebenezer N. Yamoahd, Josef Sykab,2, Bernd Fritzsche,2, and Gabriela Pavlinkovaa,2,* 8 9 Affiliations: 10 aLaboratory of Molecular Pathogenetics, Institute of Biotechnology CAS, 25250 Vestec, 11 Czechia 12 bDepartment of Auditory Neuroscience, Institute of Experimental Medicine CAS, 142 20 13 Prague, Czechia 14 cLaboratory of Gene Expression, Institute of Biotechnology CAS, 25250 Vestec, Czechia 15 dDepartment of Physiology, School of Medicine, University of Nevada Reno, NV 89557, USA 16 eDepartment of Biology, Department of Otolaryngology, University of Iowa, Iowa City, IA 17 52242-1324, USA 18 1I.F. and K.P. contributed equally to this work. 19 2contributed to the conceptualization, evaluation, and writing of this report. 20 *to whom correspondence should be addressed. 21 Email:
[email protected] 22 1 bioRxiv preprint doi: https://doi.org/10.1101/2021.09.03.458707; this version posted September 5, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 23 Abstract 24 A cardinal feature of the auditory pathway is frequency selectivity, represented in the form of 25 a tonotopic map from the cochlea to the cortex.