13th ANNUAL NIH GRADUATE STUDENT RESEARCH SYMPOSIUM THE FACES OF TOMORROW'S SCIENCE

FEBRUARY 23, 2017 NIH NATCHER CONFERENCE CENTER, BETHESDA, MARYLAND

13th ANNUAL NIH GRADUATE STUDENT RESEARCH SYMPOSIUM THE FACES OF TOMORROW'S SCIENCE

2017

FOREWORD AND ACKNOWLEDGEMENTS ...... 2

PROGRAM OF EVENTS ...... 4

NIH GRADUATE PARTNERSHIPS PROGRAM GRADUATION AWARD RECIPIENTS ...... 5

KEYNOTE SPEAKER ...... 8

STUDENT SPEAKERS ...... 9

OUTSTANDING MENTOR AWARD RECIPIENTS ...... 11

STUDENTS ...... 12

POSTERS ...... 17

Graduate Partnerships Program Office of Intramural Training & Education Office of Intramural Research National Institutes of Health U.S. Department of Health & Human Services

1 FOREWORD

very year, the National Institutes of Health (NIH) Graduate Student Research Symposium showcases the Ebreadth of scientific research and the achievements of the graduate student community at the NIH. The symposium is the largest graduate student event of the year, an event in which graduate students can come together to share their research, appreciate the work of their colleagues, and celebrate the successes of the graduate student community.

In its thirteenth year, this annual symposium provides an opportunity to acknowledge the scientific accomplishments of the hundreds of graduate students working on their dissertation research at the NIH. This symposium highlights the spectrum of scientific research conducted by graduate students at the NIH, who represent numerous universities across the world and span nearly all institutes and centers within the NIH. The NIH Graduate Research Symposium recognizes the diversity of research specialties supported by the NIH and exhibits the scientists of tomorrow, from those developing new research proposals to those preparing to defend years of dissertation research.

This symposium will provide the graduate student community with the chance to hear about the scientific work of our peers in several formats. In the morning, we will be holding our inaugural elevator pitch competition in which current graduate students will be judged on their ability to explain their science to a general audience in two minutes or less. Dr. Sharon Milgram, Director of the Office of Intramural Training and Education (OITE), will deliver welcoming remarks, followed by four current students, who will present scientific talks chosen based on scientific merit and diversity. In the afternoon, students will present their research through scientific posters judged by NIH postdoctoral fellows and staff scientists. Winners of the poster competition will be awarded the prestigious NIH Graduate Student Research Award generously funded by the OITE.

Following the poster session, we are honored to welcome our keynote speaker, Dr. Rajendrani Mukhopadhyay, managing editor at American Society for Biochemistry and Molecular Biology (ASBMB) Today. Dr. Mukhopadhyay pursued a PhD in biophysics and biochemistry in the laboratory of Dr. Jan Hoh at Johns Hopkins University. After struggling with the lack of instant gratification in science, Dr. Mukhopadhyay realized she loved the challenge of graduate school and the success of finishing. She pursued a former passion of hers after graduating and started her science-writing career at the American Chemical Society. Dr. Mukhopadhyay then joined ASBMB, writing feature stories and scientist profiles for ASBMB Today and the Wild Types blog and later becoming senior editor of ASBMB Today. She used knowledge gained from her PhD training to develop a strong sense of curiosity, the ability to ask the right questions, and the ability to frame all the information into a story—qualities necessary for a writing career and that will help us as graduate students develop a scientific project. Today, Dr. Mukhopadhyay will present how storytelling can make you a better scientist. Her story and advice will be valuable for NIH graduate students in addressing how graduate school can be an opportunity for personal growth and how graduate students can find their dream career path.

2 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

Following our keynote address, we will present the awards for outstanding research mentors. Our success as graduate students would not be the same without the guidance of high-quality research mentors, who support us in innumerable ways, from providing networking opportunities to career development advice. We are grateful for the influential mentorship provided at the NIH to help us become independent scientists and forge relationships extending beyond graduate school. Three outstanding mentors nominated by their students will be honored for their leadership, support, and dedication to their graduate students. Afterwards, we will conclude the day with a graduation ceremony to recognize those students who have defended their dissertations within the past year. Dr. Sharon Milgram will present the recent graduates with a certificate in honor of their accomplishments.

We are thankful for the opportunity to share our research with the entire NIH community at the 13th Annual NIH Graduate Student Research Symposium. We thank all of the graduate students who participated in this event and those who have provided us with continuous support in our scientific careers. We hope this event establishes new connections and collaborations, and inspires future scientific contributions to the community at the NIH.

ACKNOWLEDGEMENTS

We are grateful to the Training and Scientific Directors of the NIH Institutes and Centers, the Graduate Partnerships Program (GPP) Directors, and the Graduate Student Council (GSC) for their continuous support of the graduate student community and for the opportunity to recognize the achievements of the NIH graduate students at this symposium. We would like to thank Dr. Gail Seabold and Dr. Courtney Kurtyka for organizing the symposium poster session, and we acknowledge the effort of the postdoctoral fellow and staff scientist judges for helping to make the poster competition possible. We would like to thank the 2016 GSC co-chairs, Kara Fulton and Kimberly Breglio, for managing the Outstanding Mentor Awards and for all of their efforts and dedication to the GSC and graduate student community. This symposium would not be possible without the help of the Office of Intramural Training and Education (OITE). We are especially thankful for Dr. Sharon Milgram, Dr. Philip Wang, Dr. Phil Ryan and other OITE staff who have contributed significantly to the planning of this event. We would like to extend a big thank you to Dr. Rajendrani Mukhopadhyay for her enthusiasm and willingness to deliver our keynote address. Finally, we would like to thank the graduate students, mentors, alumni, and all attendees whose participation made this event successful.

THE 13TH ANNUAL NIH GRADUATE RESEARCH SYMPOSIUM COMMITTEE

Kimberly Breglio, NIAID/University of Oxford Leda Lotspeich-Cole, NICHD/Johns Hopkins University Carly Starke, NIAID/Georgetown University Keyla Tumas, NIAID/Georgetown University

3 PROGRAM OF EVENTS

9:00 am-10:00 am ELEVATOR PITCH COMPETITION Lower Lobby

10:00 am-10:15 am WELCOME Room E1/E2 Sharon L. Milgram, PhD Director, NIH Office of Intramural Training & Education (OITE)

10:15 am-11:45 am STUDENT ORAL PRESENTATIONS

Room E1/E2 Lydia Louis, Rutgers, The State University of New Jersey, NCI-DCEG Personal Use of Organochlorine Insecticides and Cancer Risks Among the Agricultural Health Study Farm Spouses

Nityashree Shivaprasad, Georgetown University, NCI FGFR4 specific Chimeric Antigen Receptor (CAR) T Cell Therapy Against Rhabdomyosarcoma

Rodrigo Matus Nicodemos, Johns Hopkins Univeristy, NIAID HLA-A and HLA-B Down Modulation in HIV-Infected Cells Occurs Late in the Viral Replicative Cycle

Christie Campla, University of Oxford, NEI Frmpd1: A Novel Gene Involved in Rod Photoreceptor Maturation

11:45 am-12:45 pm POSTER SESSION I Atrium Odd numbered posters presenting

12:45 pm-1:45 pm POSTER SESSION II Atrium Even numbered posters presenting

2:00 pm-3:00 pm KEYNOTE ADDRESS Ruth L. Kirschstein Rajendrani Mukhopadhyay, PhD Auditorium Managing Editor, ASBMB Today

3:00 pm-4:00 pm AWARDS CEREMONY

Ruth L. Kirschstein Graduation Ceremony Auditorium Certificates presented by: Sharon L. Milgram, PhD, Director, NIH Office of Intramural Training & Education

Outstanding Mentor Awards Daniel Reich MD, PhD John Kehrl, MD Jeffrey C. Smith, PhD

NIH Graduate Student Research Awards (NGSRAs)

4 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

GPP GRADUATION AWARD RECIPIENTS

GPP GRADUATION AWARD RECIPIENT, NIH IC, UNIVERSITY, DISSERTATION TITLE MENTOR UNIVERSITY MENTOR

Fereshteh Aalamifar CC Johns Hopkins University Co-robotic Ultrasound Tomography: A New Paradigm for Dr. Bradford Wood Dr. Emad M. Boctor Quantitative Ultrasound Imaging Dr. Peter Pinto Dr. Arman Rahmim

Defne Bayik NCI Ihsan Dogramaci Bilkent Regulation of Human Monocyte Differentiation into M1- and Dr. Dennis M. Klinman University M2-like Macrophages

Shaunna Beedie NCI University of Aberdeen An Investigation of Thalidomide Derivatives for Clinical Use Dr. William Douglas Figg Dr. Neil Vargesson

Pascale Beliveau NHLBI Ecole Polytechnique Texture Analysis of Late Gadolinium Enhanced Cardiac Dr. Li-Yueh Hsu of Montreal Magnetic Resonance Images for Characterizing Myocardial Dr. Andrew E. Arai Dr. Farida Cheriet Fibrosis and Infarction

Murat Bilgel NIA Johns Hopkins University A Multivariate Nonlinear Mixed Effects Model for Studying Dr. Susan M. Resnick Dr. Jerry L. Prince Preclinical Alzheimer’s Disease Markers of Neuropathology, Neurodegeneration, and Cognition

Allyson Lindsay Byrd NHGRI Boston University Bacterial Strain-Tracking across the Human Skin Landscape Dr. Julie Segre Dr. W. Evan Johnson in Health and Disease Dr. Yasmine Belkaid

Xiu-Tang Cheng NINDS Shanghai Jiao Tong Mechanisms Driving Axonal Transport of Autophagosomes Dr. Zu-Hang Sheng University and Defective Mitochondria

Clara Di Germanio NIA Universitá degli Studi Conditioned Medium Derived from Rat Amniotic Epithelial Dr. Rafael de Cabo di Teramo Cells Confers Protection Against Inflammation, Cancer and Dr. Barbara Barboni Senescence

Caitlin Moira Fox NICHD Johns Hopkins University The Role of Heparan Sulfate Proteoglycans During Dr. Ajay Chitnis Development of the Zebrafish Lateral Line

Armen A. Ghazarian NCI The George Washington The Testicular Dysgenesis Syndrome: Associated Maternal Dr. Katherine McGlynn University Exposures and Future Burden of Testicular Germ Cell Tumors in the U.S.

Lucas Ray Church Glover NIMH University of Oxford Examining the Contribution of Dentate Gyrus Granule Cells Dr. Heather A Cameron Professor David M and Ambiguity Toward the Stress Response and Behaviour of Bannerman the Rodent

Eleonora Guadagnin NINDS University of Padova Pathogenic Mechanisms of Collagen Type VI-Related Dr. Carsten G. Bonnemann Muscular Dystrophies

5 GPP GRADUATION AWARD RECIPIENTS

GPP GRADUATION AWARD RECIPIENT, NIH IC, UNIVERSITY, DISSERTATION TITLE MENTOR UNIVERSITY MENTOR

Kelly Andrew Hamilton NIA George Mason University Basic Helix Loop Helix Enhancer 40 in Neuronal Excitability Dr. Mark Mattson Dr. Robert Lipsky and Synaptic Plasticity

Yong He NIAAA Anhui Medical University Hepatic Mitochondrial DNA-TLR9-MicroRNA-223 Forms a Dr. Bin Gao Dr. Jun Li Negative Feedback Loop to Control Acetaminophen-Induced Acute Liver Injury and Inflammation

Jan Hoinka NLM Albert-Ludwigs- Aptamers in the Age of Big Data – Development and Dr. Teresa M. Przytycka Universität Freiburg Application of Algorithmic Solutions in the Field of High- Dr. Rolf Backofen Throughput Systematic Evolution of Ligands by Exponental Enrichment

Jessica Blythe Hostetler NIAID University of Cambridge Identification of Novel Plasmodium vivax Blood-stage Vaccine Dr. Rick Fairhurst Dr. Julian Rayner Targets

Carly Jean Houghton NHLBI Johns Hopkins University Characterization of Aerobic Respiration in the Free-Living Dr. Robert Balaban Bacterium Paracoccus denitrificans

Ayesha Imtiaz NIDCD University of the Punjab Identification of Genes Involved in Severe Degree Hearing Loss Dr. Thomas B. Friedman Dr. Sadaf Naz

Andrew Scott Ishizuka NIAID University of Oxford Pre-Clinical and Clinical Evaluation of the Malaria Vaccines Dr. Robert A. Seder Dr. Simon Draper RH5-VLP and PfSPZ Vaccine Dr. Adrian Hill

Tao Jiang NIDCD University of Maryland, Conserved Role of Emx2 in Establishing Polarity of Sensory Dr. Doris Wu College Park Hair Cells Dr. Catherine Carr

Debra L. Johnson NHLBI University of Arizona Engagement of T Cells with Antigen Presenting Cells is Dr. Julie Donaldson Dr. Jean Wilson Dependent on Clathrin- Independent Endocytic Trafficking: The Role of Arf6 and Rab22

Senta Kapnick NHGRI Johns Hopkins University Understanding Cytotoxic T lymphocyte Function Using Models Dr. Pamela Schwartzberg of Primary Immunodeficiencies

Nathan N. Lee NCI Johns Hopkins University Role of RNA Processing Machinery and Signaling Pathways Dr. Shiv Grewal in Regulating the Dynamic Epigenetic Landscape through Heterochromatin Assembly

Valeria Martinez-Kaigi NIMH University of North Texas Validating the National Institutes of Health-Brief Fatigue Dr. Carlos Zarate Dr. Charles Guarnaccia Inventory and Characterizing Fatigue Symptoms Across Dr. Rodrigo Machado- Patient Populations Vieira

6 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

GPP GRADUATION AWARD RECIPIENT, NIH IC, UNIVERSITY, DISSERTATION TITLE MENTOR UNIVERSITY MENTOR

Rafael Maso Prévide NICHD University of São Paulo Acute and Long Term Effects of Triiodothyronine on the Dr. Stanko Stojilkovic Dr. Maria Tereza Nunes Hypothalamic-Pituitary-Adrenal Axys and its Physiological Importance

Shashankkumar Jitendra Patel NCI Georgetown University A Genome-Scale CRISPR Screen to Identify Essential Genes Dr. Nicholas P. Restifo Dr. Louis Weiner for Cancer Immunotherapy

Karen Plevock Haase NHLBI University of North Regulation and Function of Centrosome Associated Proteins Dr. Nasser Rusan Carolina at Chapel Hill Dr. Kevin Slep

Sara E. Reynolds NIAID University of Maryland, Characterization of the Cowpox and Mousepox Homologs Dr. Bernard Moss College Park of the Smallpox Virus B22 Protein and their Roles in Mouse Disease Models

Davide Risso NIDCD University of Bologna Genetic Epidemiology of Taste Perception and Cigarette Use Dr. Dennis Drayna Professor Donata Luiselli

Adam Rolt NIDDK University of Liverpool Development of Inhibitors of Hepatitis C Virus Dr. T. Jake Liang Dr. Andrew V. Stachulski

Marta Sanchez NIDA Universitat de Barcelona Noncanonical Neurotransmitter Activation of Catecholamine Dr. Sergi Ferré Dr. Vicent Casadó Receptors

Jenna Marlee Shapiro NICHD University of Cambridge Hydrogel Substrate Effects on Protein Kinase A and Dr. Constantine Stratakis Dr. Michelle Oyen Osteogenesis

Emily Simons Wires NIDA University of Maryland, The Effects of Dietary Intake on Endoplasmic Reticulum Dr. Brandon Harvey Baltimore Calcium Homeostasis

Dezmond Taylor-Douglas NICHD Howard University The Role of MC3R in the Regulation of Lipogenic and Lipolytic Dr. Jack Yanovski Dr. Kebreten Manaye Processes in Mice

Sarah A. Watters NCI University College London Dynamics of HIV-1 Viral Populations in Individuals Undergoing Dr. Frank Maldarelli Chemotherapy

Yinmeng Yang NCI Georgetown University TCR Activation Impact on Chimeric Antigen Receptor Therapy Dr. Terry Fry Against Acute Lymphoblastic Leukemia

Shile Zhang NCI Boston University Integrative Analysis of the Metastatic Neuroblasotoma Dr. Javed Khan Transcriptome

7 KEYNOTE SPEAKER

RAJENDRANI (RAJ) MUKHOPADHYAY, PhD, is the managing editor of ASBMB Today, the magazine published by the American Society for Biochemistry and Molecular Biology. In 2004, right after she completed her PhD in biophysics and biochemistry from Johns Hopkins University, Raj launched her science writing career. She started off at the magazine section of the journal Analytical Chemistry at the American Chemical Society (ACS). She reported on many scientific advances and issues, including analyzing art, detecting performance-enhancing substances in athletes and figuring out if dinosaur proteins could be detected by mass spectrometry after being buried for 68 million years.

After working at the ACS for five years, Raj embarked on a freelance career as a science writer and technical editor. She contributed articles to a variety of outlets, including Chemical & Engineering News, Chemistry World, and Epigenie.com. She also blogged regularly for the Polymer Solutions Newsblog and edited grants, journal articles and technical reports for scientists.

In 2011, Raj joined ASBMB. She wrote feature stories and scientist profiles for ASBMB Today and the Wild Types blog. Stories she wrote for the magazine included the controversy over the molecular effects of vitamin D, visa and immigration issues for foreign scientists and a rare brain tumor that kills children. Her story on the pediatric tumor won an EXCEL Award for feature writing in 2016.

These days, Raj runs ASBMB Today’s operations. She is responsible for getting an awesome magazine out the door every month! Her priorities include editing every single story in the magazine so that each story is the finest story it can possibly be, collaborating with the graphic designer on the magazine’s layout, keeping track of deadlines and finding fresh voices and perspectives to capture the current issues and interests in biomedical research. Occasionally, she will go back to her roots and write a piece for the magazine.

Her advice for people looking to become science writers is to read voraciously and widely (from classic works of fiction to Buzzfeed), write at least 350 words daily, and always stay curious about the world.

8 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

STUDENT SPEAKERS

Lydia Louis In 2014, Lydia Louis, MPH, joined the Occupational and Environmental Epidemiology Branch (OEEB) of the Division of Cancer Epidemiology and Genetics (DCEG), at the NCI as a predoctoral fellow. Following a BA in cellular biology/neuroscience and French from Rutgers University Ms. Louis completed an MPH in environmental and occupational health from the Rutgers University, School of Public Health (formerly the University of Medicine and Dentistry of New Jersey). Her master’s thesis focused on the effects of the herbicide 2,3,7,8-tetrachlorodibenzo-para­ dioxin (TCDD) on human lung epithelial cells. She is currently a PhD candidate in

LYDIA the Department of Environmental and Occupational Health at Rutgers University. While in OEEB, Ms. Louis is working with investigators Melissa Friesen, PhD, and Laura Beane Freeman, PhD, examining studies of pesticide exposure determinants and cancer epidemiology among female spouses of the Agricultural Health Study, the largest U.S. cohort study of pesticide exposures and health outcomes among licensed pesticide applicators and their spouses. Ms. Louis is grateful for the immense support of both her mentors and of DCEG.

Nityashree Shivaprasad Nityashree Shivaprasad is a fourth year PhD candidate in the Georgetown–NIH GPP. Nitya completed her undergraduate studies in 2009 from University of Maryland, where she did a double major in Biochemistry (Honors) and Molecular Genetics. During her undergraduate years, she was awarded a Howard Hughes Medical Institute grant to pursue her research in the laboratory of Dr. George Lorimer. Her research focused on understanding the structural biochemistry of the chaperone protein GroEL. After graduation, she worked at Medimmune, where she focused on developing antibody based therapeutics. During this

NITYA time, she also completed her master’s degree at Johns Hopkins University, specializing in translational research and drug discovery. In 2013, she entered the NIH-Georgetown partnership PhD program, and she is currently working in the NCI Oncogenomics, under the mentorship of NCI Genetics Branch Deputy Chief Dr. Javed Khan and Dr. Rimas Orentas of Lentigen Inc. Her thesis research focuses mainly on developing immune-based therapies for the treatment of pediatric tumors. Nitya is investigating cancer antigens that can be targeted by the immune cells and developing pre-clinical therapeutics for treatment of pediatric rhabdomyosarcoma. She is delighted to work with both her mentors, whose effective collaboration has provided her with the opportunity to work in both an academic and industrial environment on translational science research with the potential to impact clinical treatment of pediatric cancers.

9 STUDENT SPEAKERS

Rodrigo Matus Nicodemos Rodrigo is a third year PhD candidate in the NIH–Johns Hopkins University Graduate Partnership Program. He received a BA in Genetics and MS in Microbiology and Molecular Genetics from Rutgers University. At Rutgers he studied the post-transcriptional regulation of CD40 ligand in CD4 T cells in the laboratory of Dr. Lori Covey. He later joined the Human Immunology Section of the Immunology Laboratory at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID) as a Technical IRTA. Under the mentorship of Drs. Richard Koup and Daniel Douek, Rodrigo worked to understand

RODRIGO the role of T cell receptor (TCR) recognition in the natural control of HIV-1 infection. From this work he discovered new parameters that contribute to the control of HIV-1 and has expanded that work to a PhD project with Drs. Koup and Douek to determine the requirements for recognition and elimination of HIV-infected cells by CD8 T cells. He is grateful for the opportunity to conduct HIV research that can help combat this infectious disease, as well as for the wonderful learning experiences he has obtained from the VRC and NIH community.

Christie Campla Christie first began research in the lab of Dr. Meera Nanjundan at the University of South Florida where she focused on the role of various TGFβ signaling mediators and aberrantly spliced genes in autophagy and epithelial-mesenchymal transition in ovarian cancer. As an undergraduate at USF, Christie also worked in the Protein Engineering & Dynamic Living Systems Lab on genetically encodable elastin-like peptides for treatment of chronic wounds as well as the Epithelial Carcinogenesis Lab at CNIO in Madrid investigating the role of c-myc in the development of pancreatic ductal adenocarcinoma. As part of the NIH-OxCam PhD program,

CHRISTIE Christie works jointly in the Nuffield Laboratory of Ophthalmology with Drs. Stephanie Halford and Sumathi Sekaran at Oxford as well as in the Neurobiology- Neurodegeneration and Repair Laboratory with Dr. Anand Swaroop at the NEI. Her current research is aimed towards understanding what controls appropriate development and homeostasis of rod photoreceptors by carrying out a detailed molecular and functional characterization of novel genes associated with these processes, with the intent of improving cell therapies to create more functional and viable cells for use in photoreceptor transplants.

10 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

OUTSTANDING MENTOR AWARD RECIPIENTS

John Kehrl, MD Dr. John Kehrl graduated from Michigan State University with a BS in Mechanical Engineering, then attended medical school at Wayne State University followed by an Internal Medicine residency at Yale University. He came to the NIH as a Clinical Associate in the Laboratory of Clinical Investigation and then the Laboratory of Immunoregulation. He became a Senior Investigator in the Laboratory of Immunoregulation and then Chief of B-Cell Molecular Immunology Section. He has a broad background in immunology and G-protein signaling having published extensively in these fields. His laboratory research program aims to understand

DR. KEHRL how G-protein-coupled receptors (GPCR) transduce signals to downstream effectors in immune cells, to discern the mechanisms that control these responses, and to determine the physiologic consequences of G-protein activation for lymphocyte function. Their studies make extensive use of gene modified mice that have disruption of key genes in the chemokine receptor signaling pathway and sophisticated imaging techniques including intravital two-photon laser scanning microscopy (TP-LSM). As an extension of these studies, his lab is also characterizing the functional roles of G-proteins, their regulators in a non- canonical G-protein signaling pathway, which employs alternative activators and effectors. Finally, they are investigating some aspects of the signaling pathway that triggers autophagy and inflammasome activation in macrophages and other cell types. In these studies they focus on the intersection between G-protein signaling and inflammatory pathways.

Daniel Reich, MD, PhD Dr. Daniel Reich is Senior Investigator at NIH/NINDS, where he directs the Translational Neuroradiology Section and leads clinical studies focusing on Multiple Sclerosis (MS). He studied math and physics at Yale and earned his MD from Cornell and his PhD in neurophysiology from The Rockefeller University. His training includes a fellowship in diagnostic neuroradiology and residencies in radiology and neurology at Johns Hopkins. He is a founder of the North American Imaging in MS cooperative and serves on the Advisory Committee of ACTRIMS and the Scientific Advisory Board of the Race to Erase MS. He is an elected member DR. REICH of the American Society of Clinical Investigation, the 2015 winner of the American Neurological Association’s Derek Denny-Brown Young Neurological Scholar Award, and the 2016 winner of the National MS Society’s Barancik Award for Innovation in MS Research. Dr. Reich’s lab develops advanced MRI techniques to understand MS and adapts those techniques for clinical trials and patient care. The lab harnesses noninvasive imaging modalities to dissect biological mechanisms of tissue damage, both by performing longitudinal studies on time scales relevant for disease processes and by examining radiological-pathological correlations in autopsy tissue and animal models.

11 OUTSTANDING MENTOR AWARD RECIPIENTS

Jeffrey C. Smith, PhD Dr. Jeffrey C. Smith received his BS degree in biological sciences from the University of Maryland, College Park in 1973, and his PhD degree in physiology from Johns Hopkins University in 1979. Subsequently, he held postdoctoral and research associate positions in physiology at Harvard University and Northwestern University. He was a Humboldt Fellow at the Physiological Institute, University of Göttingen, Germany in 1990, and appointed in 1991 as Associate Professor in the Department of Physiological Science at UCLA, where he was also a faculty member in the Interdepartmental Program in Neuroscience. His research at

DR. SMITH UCLA was supported in part by a NIH Research Career Development Award, and he served as chairman of the departmental Graduate Affairs Committee. He moved to the Basic Neuroscience Program at NINDS as a Senior Investigator in 1994 and was appointed Chief of the Cellular and Systems Neurobiology Section (CSNS) in 1997. Research in the CSNS applies interdisciplinary experimental and computational neuroscience approaches to investigate basic neurophysiological mechanisms in the nervous system controlling breathing in mammals. He has mentored 25 postdoctoral, graduate, and post-baccalaureate trainees, and over 25 undergraduate trainees including students who have received Goldwater, Fulbright, Truman, or Rhodes Scholarships.

12 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

STUDENTS Listed alphabetically by name

Poster # Last Name, First IC University 27 Abaandou, Laura NIDDK George Mason University

94 Agbaegbu Iweka, Chinyere NHLBI Georgetown University

117 Aguiluz-Abunto, Maria Rosario NIA University of Pittsburgh Graduate School of Public Health

56 Alderson, Thomas NIDDK University of Oxford

69 Ansbro, Megan NIAID University of Cambridge

84 Arthofer, Elisa NICHD Karolinska Institute

85 Auslander, Noam NCI University of Maryland, College Park

93 Awasthi, Shivangi NCI University of Maryland, Baltimore

70 Baird, Michelle NHLBI University of Maryland, College Park

12 Breglio, Andrew NIDCD University of Oxford

20 Breglio, Kimberly NIAID University of Oxford

95 Brown, Markus NCI University of Maryland, College Park

64 Bullock, Jeanee NEI Georgetown University

86 Burke, Dennis NIAAA Brown University

38 Burnett, Joey NIDDK Brown University

5 Caffrey, Brian NCI University College Dublin

72 Campla, Christie NEI University of Oxford

58 Chen, Song NCI University of Maryland, College Park

102 Chiang, Wen-Yang NINDS Texas A&M University

31 Chopp, Laura NCI University of Pennsylvania

82 Clarke, Akanni NINDS The George Washington University

66 Collins, Joshua NIDCR Johns Hopkins University

18 Coonahan, Erin NIAID University of Oxford

6 Corps, Kara NINDS North Carolina State University

91 Cramer, Sarah NCI University of Maryland, College Park

109 Dashtestani, Hadis NICHD University of Maryland, Baltimore County

49 Davies, Sarah NHLBI Georgetown University

97 Dawson, Eric NCI-DCEG University of Cambridge

81 Deasy, Sarah NCI The George Washington University

62 Demmerle, Justin NICHD University of Oxford

1 Dennis, Allison NICHD Johns Hopkins University

108 Deuitch, Lora NIMH Karolinska Institutet

55 Dildine, Troy NCCIH Karolinska Institutet

41 Dold, Neil NCI University of Maryland, College Park

44 DuChez, Brian NIDCR Georgetown University

13 STUDENTS Listed alphabetically by name

Poster # Last Name, First IC University 110 Erben, Larissa NICHD University of Bonn

26 Fallon, Rebecca NIDA Johns Hopkins University

39 Fernandopulle, Michael NINDS University of Cambridge, Northwestern University Feinberg School of Medicine

98 Fulton, Kara NINDS Brown University

9 Garcia Grisales, David NCI University of Maryland, College Park

16 Gola, Anita NIAID University of Oxford

29 Gorrell, Laura NICHD Rensselear Polytechnic Institute

34 Grodin, Erica NIAAA Brown University

74 Hargrove, Passley NEI The George Washington University

53 Humble, Stewart NINDS University of Oxford, LSUHSC New Orleans

52 Hyun, Seong-In NIAID University of Maryland, College Park

71 Inwood, Sarah NIDDK Johns Hopkins University

2 Islam, Rafique NHLBI George Mason University

37 Jones, Michael NHLBI Michigan State University

32 Kesner, Andrew NIDA Johns Hopkins University

47 Kimmich, Sara NIMH University College London

99 LaBarre, Brenna NHGRI Boston University

88 Lee, Nathanael NINDS Georgetown University

89 Leshem, Jasmin NCI Technion-Israel Institute of Technology

75 Levy, Emily NHLBI The George Washington University

59 Lingemann, Matthias NIAID Baunschweig University of Technology

46 Lotspeich-Cole, Leda NICHD Johns Hopkins University

30 Louis, Lydia NCI-DCEG Rutgers, The State University of New Jersey

3 Magen, Assaf NCI University of Maryland, College Park

48 Marler, Laura NICHD Johns Hopkins University

111 Marquart, Gregory NICHD University of Maryland, College Park

22 Martinez-Kaigi, Valeria NIMH University of North Texas

35 Matson, Matthew NIAID Marshall University Joan C. Edwards School of Medicine

77 Matus-Nicodemos, Rodrigo NIAID Johns Hopkins University

19 McCann, Katelyn NIAID University of Massachusetts Medical School

79 Michael, Helen NCI University of Maryland, College Park

87 Miller, Brendan NHGRI Johns Hopkins University

113 Miller, Stephanie NIMH University of Maryland, College Park

14 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

Poster # Last Name, First IC University 54 Mirzaeimoghri, Mona NHLBI University of Maryland, College Park

57 Mukhamedoza, Maryam NIAID Johns Hopkins University

7 Ng, Caleb NIAID University of Pennsylvania

100 Nguyen, Thien NINDS Georgetown University

50 Nixon-Abell, Jonathon NINDS University College London

103 Park, Kyemyung NIAID University of Maryland, College Park

83 Patange, Simona NCI University of Maryland, College Park

21 Patel, Keval NHLBI University of Cambridge

105 Phillips, Ryan NINDS University of New Hampshire

8 Pourshafie, Naemeh NINDS The George Washington University

51 Prescott, Stephanie NINR University of Virginia

45 Prestil, Ryan NINDS University of Cambridge

61 Richoz, Nathan NIAMS University of Cambridge

17 Roney, Joseph NINDS University of Oxford

104 Rubinstein, Dani NIMH Brown University

73 Russo, Matthew NINDS Johns Hopkins University

106 Saglam, Aybike NINDS University of Maryland, College Park

119 Samarjeet, Samar NHLBI Johns Hopkins University, School of Medicine 24 Sarigiannidis, Ioannis NIMH University College London

14 Schmidt, Keith NCI Utrecht University

15 Schneller, Jessica NHGRI SUNY Stony Brook

80 Sciascia, Nicholas NCI The George Washington University 10 Sengupta, Abhishek NEI University of Paris

90 Sengupta, Ayesha NIAAA University of Oxford

92 Sheikhbahaei, Shahriar NINDS University College London

4 Shivaprasad, Nityashree NCI Georgetown University

33 Shumway, Lukas NINDS Johns Hopkins University

36 Silverstein, Shana NIAAA University College London

115 Spurrier, Josh NINDS Johns Hopkins University

63 Starke, Carly Elizabeth NIAID Georgetown University

65 Stuart, Carey NIAID University of Maryland, College Park

107 Tisza, Michael NCI Johns Hopkins University

23 Tumas, Keyla NIAID Georgetown University

43 Velazquez-Kronen, Raquel NCI-DCEG University at Buffalo

15 Poster # Last Name, First IC University 60 Vemu, Annapurna NINDS Johns Hopkins University

101 Wang, Cuicui NIEHS Fudan Univerisity

42 Watson, Dionysios (Dennis) NCI University of Patras

28 Weaver, Kristen NINR New York University

40 Westwater, Margaret NIDDK University of Cambridge

96 Whitaker, D. Thad NEI Texas A&M University

76 Wong, Hiu-tung NIDCD Johns Hopkins University

78 Wong, Sing Wai NIEHS University of North Carolina at Chapel Hill

68 YAU, Ka Chun NICHD The Chinese University of Hong Kong

25 Yenkoidiok Douti, Lampouguin NIAID University of Maryland, College Park

67 Yolitz, Jason NIAID Johns Hopkins University

13 Young, Jennifer NCI University of Maryland, College Park

11 Zabala Alemán, Gabriela NIMH Universidad Central del Caribe

16 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

POSTERS

1 6 What Lies Beneath: Exposing Hidden Single-strand Breaks Transcranial Application of A2A Receptor Agonists through Transcriptional Pauses Ameliorates Mild Traumatic Brain Injury Allison Dennis and David J. Clark Kara N. Corps, Kenneth Jacobson and Dorian B. McGavern Graduate Student Name: Allison Dennis Graduate Student Name: Kara N. Corps NIH Institute-Center: NICHD NIH Institute-Center: NINDS NIH and University Research Advisor: Dr. David J. Clark NIH Research Advisor: Dr. Dorian B. McGavern Graduate University: Johns Hopkins University University Research Advisor: Dr. John Cullen Graduate University: North Carolina State University 2 Structure Function Studies of Apolipoprotein A-I Mimetic 7 Peptides for Cardiovascular Disease Therapy Potential Autoimmune Consequences of Outlier T Cell Rafique M. Islam, Denis Sviridov, Scott Gordon and Responses Driven by Small Gene Expression Changes Alan Remaley Caleb E. Ng, Harikesh Wong and Ronald N. Germain Graduate Student Name: Rafique M. Islam Graduate Student Name: Caleb E. Ng NIH Institute-Center: NHLBI NIH Institute-Center: NIAID NIH Research Advisor: Dr. Alan T. Remaley NIH Research Advisor: Dr. Ronald N. Germain University Research Advisor: Dr. Ancha Baranova Graduate University: University of Pennsylvania Graduate University: George Mason University 8 3 MiR-298 Counteracts Mutant Androgen Receptor Toxicity Investigating T Cell Differentiation Using Single Cell in Spinal and Bulbar Muscular Atrophy Transcriptomes Naemeh Pourshafie, Philip R. Lee, Ke-lian Chen, Assaf Magen, Thomas Ciucci, Sridhar Hannenhalli George G. Harmison, Laura C Bott, Masahisa Katsuno, and Remy Bosselut Gen Sobue, Barrington G. Burnett, Kenneth H. Fischbeck Graduate Student Name: Assaf Magen and Carlo Rinaldi NIH Institute-Center: NCI Graduate Student Name: Naemeh Pourshafie NIH Research Advisor: Dr. Remy Bosselut NIH Institute-Center: NINDS University Research Advisor: Dr. Sridhar Hannenhalli NIH Research Advisor: Dr. Kenneth Fischbeck Graduate University: University of Maryland, College Park University Research Advisor: Dr. Norman Lee Graduate University: The George Washington University 4 FGFR4 Specific Chimeric Antigen Receptor (CAR) T Cell 9 Therapy Against Rhabdomyosarcoma Mechanotransduction and Transcription Factor Dynamics Nityashree Shivaprasad, Ying Xiong, Dina Schneider, David A. Garcia Grisales, Diego Presman and Gordon Hager Darong Wu, Joon-Yong Chung, Marielle Yohe, Jack Shern, Graduate Student Name: David A. Garcia Grisales Jun Wei, Zhongyu Zhu, Dimiter Dimitrov, Stephen Hewitt, NIH Institute-Center: NCI Poul Sorensen, Rimas Orentas and Javed Khan NIH Research Advisor: Dr. Gordon Hager Graduate Student Name: Nityashree Shivaprasad University Research Advisor: Dr. Arpita Upadhyaya NIH Institute-Center: NCI Graduate University: University of Maryland, College Park NIH Research Advisors: Dr. Javed Khan and Dr. Rimas Orentas University Research Advisor: Dr. Anton Wellstein 10 Graduate University: Georgetown University Red-shifted Channelrhodopsin Stimulation Restores Light Responses in Blind Mice, Macaque Retina and 5 Human Retina Molecular Determination of Biomolecules on the Abhishek Sengupta, Antoine Chaffiol, Emilie Macé, Romain Surface of Nanoparticles Caplette, Mélissa Desrosiers, Maruša Lampi, Valérie Forster, Brian J. Caffrey, Daithi Garry and Kenneth Dawson Olivier Marre, John Lin, José-Alain Sahel, Serge Picaud, Graduate Student Name: Brian J. Caffrey Deniz Dalkara, Jens Duebel and Wei Li NIH Institute-Center: NCI Graduate Student Name: Abhishek Sengupta NIH Research Advisor: Dr. Sriram Subramaniam NIH Institute-Center: NEI University Research Advisor: Prof. Kenneth Dawson NIH Research Advisor: Dr. Wei Li Graduate University: University College Dublin University Research Advisor: Prof. Jens Duebel Graduate University: University of Paris 06

17 POSTERS

11 16 Differential Roles of Dopamine in the Striatum and the Prime and Target Immunization Protects Against Amygdala in Reinforcement Learning Liver-Stage Malaria Gabriela M. Zabala Alemán, Johann F. Du Hoffmann, Bruno Anita Gola, Adam A. Walters, Stefan Uderhardt, Benedict R. B. Averbeck and Yogita Chudasama Halbroth, Ahmed M. Salman, Shahid M. Khan, Chris J. Janse, Graduate Student Name: Gabriela M. Zabala Alemán Ronald N. Germain, Alexandra J. Spencer and Adrian V. Hill NIH Institute-Center: NIMH Graduate Student Name: Anita Gola NIH Research Advisor: Dr. Bruno B. Averbeck NIH Institute-Center: NIAID University Research Advisor: Dr. Luis Cubano NIH Research Advisor: Dr. Ronald N. Germain Graduate University: Universidad Central del Caribe University Research Advisor: Dr. Adrian V. Hill Graduate University: University of Oxford 12 Cisplatin-Induced Hearing Loss is Associated with 17 Long-Term Drug Accumulation in the Cochlea Mechanisms Regulating Axonal Autophagosome-Lysosome Andrew M. Breglio, Aaron Rusheen, Eric Shide, Katharine Transport in the Glycosphingolipid Lysosomal Storage Fernandez, Lauren Amable and Lisa Cunningham Disorder Niemann-Pick Type C Graduate Student Name: Andrew M. Breglio Joseph C. Roney, Tamar Farfel-Becker, Xiu-Tang Cheng, NIH Institute-Center: NIDCD Frances M. Platt and Zu-Hang Sheng NIH Research Advisor: Dr. Lisa Cunningham Graduate Student Name: Joseph C. Roney University Research Advisor: Dr. Matthew J.A. Wood NIH Institute-Center: NINDS Graduate University: University of Oxford NIH Research Advisor: Dr. Zu-Hang Sheng University Research Advisor: Professor Frances M. Platt 13 Graduate University: University of Oxford Family Matters in Li-Fraumeni Syndrome: Using Multiple Methods to Identify Relational Coping in Couples 18 Jennifer Young, Norman Epstein, Allison Werner-Lin Development of a Field-Based Point-of-Care Assay to and Mark Greene Detect Antimalarial Drugs from Unprocessed Fingerstick Graduate Student Name: Jennifer Young Blood Samples NIH Institute-Center: NCI Joel Tarning, Maarten De Vos and Rick Fairhurst NIH Research Advisor: Dr. Mark Greene Graduate Student Name: Erin Coonahan University Research Advisor: Dr. Norman Epstein NIH Institute-Center: NIAID Graduate University: University of Maryland, College Park NIH Research Advisor: Dr. Rick Fairhurst University Research Advisor: Dr. Maarten De Vos, Dr. Joel Tarning 14 Graduate University: University of Oxford The Effects of pH on the Physicochemical Properties of CRLX101 – A Novel Investigational Nanoparticle-Drug 19 Conjugate (NDC) The Regulation and Function of IRG1 in Human Monocytes Keith T. Schmidt, Jessica Kindrick, Cody J. Peer and and Macrophages William D. Figg Katelyn J. McCann, Amy Hsu, Elizabeth Sampaio, Masashi Graduate Student Name: Keith T. Schmidt Matsuyama, Anuj Kashyap and Steve Holland NIH Institute-Center: NCI Graduate Student Name: Katelyn J. McCann NIH Research Advisor: Dr. William D. Figg NIH Institute-Center: NIAID University Research Advisor: Dr. Jan H. Schellens NIH Research Advisor: Dr. Steven Holland Graduate University: Utrecht University University Research Advisor: Dr. Beth McCormick Graduate University: University of Massachusetts Medical School 15 Targeted Genome Editing Using CRISPR to Correct a 20 Mouse Model of Methylmalonic Acidemia (MMA) Autophagy in Artemisinin-Resistant Plasmodium Falciparum Jessica L. Schneller, Ciaran M. Lee, Randy J. Chandler, Kimberly F. Breglio, Pharath Lim, Roberto Amato, Thomas J. Cradick, Gang Bao and Charles P. Venditti David Roberts, Katja Simon and Rick Fairhurst Graduate Student Name: Jessica L. Schneller Graduate Student Name: Kimberly F. Breglio NIH Institute-Center: NHGRI NIH Institute-Center: NIAID NIH Research Advisor: Dr. Charles P. Venditti NIH Research Advisor: Dr. Rick Fairhurst Graduate University: State University of New York Stony Brook University Research Advisor: Dr. Katja Simon Graduate University: University of Oxford

18 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

21 26 Identifying the Location of the Water Permeability in Characterizing Fos-expressing Neuronal Ensembles Rat Mesenteric Artery Using CARS Microscopy Associated with Amphetamine Sensitization in Rat Keval D. Patel, Betrand Lucotte and Robert S. Balaban Nucleus Accumbens Graduate Student Name: Keval Patel Rebecca Fallon, F. Javier Rubio, Brandon Warren and NIH Institute-Center: NHLBI Bruce Hope NIH Research Advisor: Dr. Robert Balaban Graduate Student Name: Rebecca Fallon University Research Advisor: Prof. Michelle Oyen NIH Institute-Center: NIDA Graduate University: University of Cambridge NIH Research Advisor: Dr Bruce Hope Graduate University: Johns Hopkins University 22 Validating the NIH-Brief Fatigue Inventory Across 27 Patient Populations Creation and Characterization of Stable HEK 293 Valeria Martinez-Kaigi, Carlos Zarate, Mutant Cell Lines with Increased Protein Expression Rodrigo Machado-Vieira and David Luckenbough Potential Using High Throughput siRNA Screening and Graduate Student Name: Valeria Martinez-Kaigi CRISPR Gene Editing NIH Institute-Center: NIMH Laura I. Abaandou and Yossi Shiloach NIH Research Advisor: Dr. Carlos Zarate Graduate Student Name: Laura I Abaandou University Research Advisor: Dr. Charles Guarnaccia NIH Institute-Center: NIDDK Graduate University: University of North Texas NIH Research Advisor: Dr. Yossi Shiloach University Research Advisor: Dr. Bishop 23 Graduate University: George Mason University Characterizing the Role of T Regulatory Cells in Rodent Malaria Infections 28 Keyla Tumas, Jian Wu, Norinne Lacerda Quieroz and Stress Perceptions, Physiological Correlates and Quality Xin-Zhuan Su of Life, in Patients with Irritable Bowel Syndrome Graduate Student Name: Keyla Tumas Kristen R. Weaver, Gail D. Melkus, Jason Fletcher NIH Institute-Center: NIAID and Wendy A. Henderson NIH Research Advisor: Dr. Xin-Zhuan Su Graduate Student Name: Kristen R. Weaver Graduate University: Georgetown University NIH Institute-Center: NINR NIH Research Advisor: Dr. Wendy A. Henderson 24 University Research Advisor: Dr. Gail D'Eramo Melkus Time Also Flies When You are Not Having Fun: Graduate University: New York University The Impact of Induced Anxiety on Time Perception Ioannis Sarigiannidis, Monique Ernst, Christian Grillon, 29 Jonathan Roiser and Oliver Robinson Using RNA guided Nucleases to Tag and Edit Type I Graduate Student Name: Ioannis Sarigiannidis Collagen in Order to Study Procollagen Trafficking in NIH Institute-Center: NIMH Murine Osteoblasts NIH Research Advisor: Dr. Christian Grillon, Dr. Monique Ernst Laura Gorrell, Shakib Omari, Anna Roberts-Pilgrim, Elena University Research Advisor: Dr. Jonathan Roiser, Makareeva and Sergey Leikin Dr. Oliver Robinson Graduate Student Name: Laura Gorrell Graduate University: University College London NIH Institute-Center: NICHD NIH Research Advisor: Dr. Sergey Leikin 25 University Research Advisor: Dr. Mariah Hahn Assessing the Potential of Plasmodium P47 as Graduate University: Rensselear Polytechnic Institute a Malaria Transmission Blocking Vaccine Lampouguin Y. Douti, Gaspar Canepa and Carolina Barillas-Murry Graduate Student Name: Lampouguin Y. Douti NIH Institute-Center: NIAID NIH Research Advisor: Dr. Carolina Barillas-Mury University Research Advisor: Dr. Christopher Jewell Graduate University: University of Maryland, College Park

19 POSTERS

30 35 Personal Use of Organochlorine Insecticides and Cancer Ebola Virus Disease (EVD) and Bacterial Co-Infection Risks Among the Agricultural Health Study Farm Spouses M. Jeremiah Matson, Vincent J. Munster and Lydia M. Louis, Catherine C. Lerro, Melissa C. Friesen, Daniel S. Chertow Gabriella Andreotti, Stella Koutros, Dale P. Sandler, Graduate Student Name: M. Jeremiah Matson Aaron Blair, Mark G. Robson and Laura E. Beane Freeman NIH Institute-Center: NIAID Graduate Student Name: Lydia M. Louis NIH Research Advisor: Dr. Vincent J. Munster NIH Institute-Center: NCI-DCEG University Research Advisor: Dr. Hongwei D. Yu NIH Research Advisor: Dr. Laura Beane Freeman Graduate University: Marshall University Joan C. Edwards and Dr. Melissa Friesen School of Medicine University Research Advisor: Dr. Mark Robson Graduate University: Rutgers, The State University 36 of New Jersey Neural Circuits Underlying Vicariously Learned Fear Shana E. Silverstein, Olena Bukalo, Abby Postle, 31 Aaron Limoges and Andrew Holmes Investigating CD4 Lineage Differentiation in the Thymus Graduate Student Name: Shana E. Silverstein Laura B. Chopp and Rémy Bosselut NIH Institute-Center: NIAAA Graduate Student Name: Laura B. Chopp NIH Research Advisor: Dr. Andrew Holmes NIH Institute-Center: NCI University Research Advisor: Dr. Essi Viding NIH Research Advisor: Dr. Rémy Bosselut Graduate University: University College London University Research Advisor: Dr. Rémy Bosselut Graduate University: University of Pennsylvania 37 Structure, Activity, and Chemical Recognition of pH and 32 Ionic Strength Induced Protein-Protein Interactions Optogenetic Dissection of a Novel Reward Circuit Michael R. Jones, Bernard. R. Brooks and Angela K. Wilson Andrew J. Kesner and Satoshi Ikemoto Graduate Student Name: Michael R. Jones Graduate Student Name: Andrew J. Kesner NIH Institute-Center: NHLBI NIH Institute-Center: NIDA NIH Research Advisor: Dr. Bernard R. Brooks NIH Research Advisor: Dr. Satoshi Ikemoto University Research Advisor: Dr. Angela K. Wilson Graduate University: Johns Hopkins University Graduate University: Michigan State University

33 38 Exploring the Interactions Between the Extracellular Hunger-Driven Motivational State Competition Domains of NMDA and AMPA Receptors and Neuroligins C. Joseph Burnett, Chia Li, Emily Webber, Eva Tsaousidou, Lukas J. Shumway and Katherine Roche Stephen Y. Xue, Jens C. Bruning and Michael J. Krashes Graduate Student Name: Lukas J. Shumway Graduate Student Name: C. Joseph Burnett NIH Institute-Center: NINDS NIH Institute-Center: NIDDK NIH Research Advisor: Dr. Katherine Roche NIH Research Advisor: Dr. Michael J. Krashes University Research Advisor: N/A Graduate University: Brown University Graduate University: Johns Hopkins University 39 34 Interrogating the Selective Vulnerability of Neuronal The Neural Correlates of Aversion Resistant Subpopulations in FTD and ALS Alcohol Seeking Michael S. Fernandopulle and Michael E. Ward Erica N. Grodin, Kelsy Sundby, Lauren Sussman, Graduate Student Name: Michael S. Fernandopulle Grace Brennan, Vijay Ramchandani, Markus Heilig NIH Institute-Center: NINDS and Reza Momenan NIH Research Advisor: Dr. Michael E. Ward Graduate Student Name: Erica N. Grodin University Research Advisor: Prof. Peter St. George-Hyslop NIH Institute-Center: NIAAA Graduate University: University of Cambridge, Northwestern NIH Research Advisor: Dr. Reza Momenan University Feinberg School of Medicine Graduate University: Brown University

20 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

40 45 Functional Integration of Homeostatic and Visual Signals Investigating Dysregulated Autophagy in Spinal and in the Obese State Bulbar Muscular Atrophy Margaret L. Westwater, W. Kyle Simmons, Alex Martin Ryan Prestil, Kenneth Fischbeck and David Rubinsztein and Kevin D. Hall Graduate Student Name: Ryan Prestil Graduate Student Name: Margaret L. Westwater NIH Institute-Center: NINDS NIH Institute-Center: NIDDK NIH Research Advisor: Dr. Kenneth Fischbeck NIH Research Advisor: Dr. Kevin Hall University Research Advisor: Prof. David Rubinsztein University Research Advisor: Prof. Paul Fletcher Graduate University: University of Cambridge Graduate University: University of Cambridge 46 41 Ascorbate Mediated Translational Regulation of the Formulation of Vaccines With Self-Assembled Nucleic GDP-L-Galactose Phosphorylase (GGP) Enzyme Acid Adjuvants to Promote Tumor Immunity Leda E. Lotspeich-Cole and Thomas Dever Neil M. Dold, Lorena Parlea, Joost J. Oppenheim, Graduate Student Name: Leda Lotspeich-Cole Bruce A. Shapiro and Christopher M. Jewell NIH Institute-Center: NICHD Graduate Student Name: Neil M. Dold NIH Research Advisor: Dr. Thomas Dever NIH Institute-Center: NCI Graduate University: Johns Hopkins University NIH Research Advisor: Dr. Bruce A. Shapiro University Research Advisor: Dr. Christopher M. Jewell 47 Graduate University: University of Maryland, College Park Know Thy Brain, Change Thyself: Understanding the Neurocognition of Real Time Neurofeedback 42 Sara Kimmich and Peter Bandettini Extracellular Vesicles for Tumor-Enhanced Delivery of Graduate Student Name: Sara Kimmich Immunotherapy: Overcoming Barriers in Production, NIH Institute-Center: NIMH Purification and Delivery NIH Research Advisor: Dr. Peter Bandettini Dionysios C. Watson, Defne Bayik, Avinash Srivatsan, University Research Advisor: Prof. Geraint Rees Bryant Yung, Cristina Bergamaschi, Jenifer Bear, Aizea Graduate University: University College London Morales-Kastresana, Jennifer C. Jones, Barbara K. Felber, Xiaoyuan Chen, Ihsan Gursel and George N. Pavlakis 48 Graduate Student Name: Dionysios C. Watson 40S Ribosomal Protein Rps26 Plays a Critical Role in NIH Institute-Center: NCI Accurate Start Codon Selection During Translation NIH Research Advisor: Dr. George N. Pavlakis Initiation In Vivo University Research Advisor: Dr. George Z. Panos Laura Marler, Jyothsna Visweswaraiah and Graduate University: University of Patras, Greece Alan G. Hinnebusch Graduate Student Name: Laura Marler 43 NIH Institute-Center: NICHD Radiation-Related Health Risks Associated with NIH Research Advisor: Dr. Alan Hinnebusch Protracted Low-Dose Occupational Radiation Exposure in Graduate University: Johns Hopkins University U.S. Radiologic Technologists Raquel Velazquez-Kronen, Cari Kitahara, Martha Linet, 49 Kirsten Moysich and Ethel Gilbert Targeting Polyomaviruses Using Adoptive T Cell Graduate Student Name: Raquel Velazquez-Kronen Immunotherapy NIH Institute-Center: NCI-DCEG Sarah I. Davies, Pawel Muranski, Greg Whitehill, NIH Research Advisor: Dr. Cari Kitahara Keyvan Keyvanfar, Quan Yu, Mark Chang and A. John Barrett University Research Advisor: Dr. Kirsten Moysich Graduate Student Name: Sarah I. Davies Graduate University: University at Buffalo NIH Institute-Center: NHLBI NIH Research Advisor: Dr. A. John Barrett and 44 Dr. Pawel Muranski Directional Migration of Cancer Cells In Response to Graduate University: Georgetown University a Stiffness Gradient is Potentiated by Rapid Protrusion and Retraction Dynamics Brian J. DuChez and Kenneth M. Yamada Graduate Student Name: Brian J. DuChez NIH Institute-Center: NIDCR NIH Research Advisor: Dr. Kenneth M. Yamada University Research Advisor: Dr. Daniel Blair Graduate University: Georgetown University 21 POSTERS

50 55 Increased Spatiotemporal Resolution Reveals Highly An Investigation of Health Disparities in Pain Dynamic Dense Tubular Matrices in the Peripheral ER Troy C. Dildine, Andreas Olsson and Lauren Y. Atlas Jonathon Nixon-Abell, Christopher J. Obara, Aubrey V. Graduate Student Name: Troy C. Dildine Weigel, Dong Li, Wesley R. Legant, C. Shan Xu, H. Amalia NIH Institute-Center: NCCIH Pasolli, Kristen Harvey, Harald F. Hess, Eric Betzig, NIH Research Advisor: Dr. Lauren Y. Atlas Craig Blackstone and Jennifer Lippincott-Schwartz University Research Advisor: Dr. Andreas Olsson Graduate Student Name: Jonathon Nixon-Abell Graduate University: Karolinska Institutet NIH Institute-Center: NINDS NIH Research Advisor: Dr. Craig Blackstone 56 University Research Advisor: Prof Kirsten Harvey Structural Basis for the Redox Regulation of the Human Graduate University: University College London Molecular Chaperone HSP27 T. Reid Alderson, Julien Roche, Heidi Y. Gastall, 51 Iva Pritisanac, Ad Bax, Justin L. P. Benesch and Effects of Antibiotic Exposure During Parturition Andrew J. Baldwin on Offspring Immune Development Graduate Student Name: T. Reid Alderson Stephanie M. Prescott, Ernesto Perez-Chanona, NIH Institute-Center: NIDDK Giorgio Trinchieri and Wendy Henderson NIH Research Advisor: Dr. Ad Bax Graduate Student Name: Stephanie M. Prescott University Research Advisor: Profs. Andrew J. Baldwin and NIH Institute-Center: NINR Justin L. P. Benesch NIH Research Advisor: Dr. Giorgio Trinchieri, Graduate University: University of Oxford Dr. Wendy Henderson University Research Advisor: Dr. Jessica Keim-Malpass, 57 Dr. Donna Schminke Unbiased Evaluation of Antibody Repertoire using Graduate University: University of Virginia Heavy and Light Chain Linkage Reaction Maryam Mukhamedova, Brandon Dekosky, Daniel Douek 52 and John Mascola Vaccinia Virus Protein I2 is Required for a Critical Stage Graduate Student Name: Maryam Mukhamedova in Virus Morphogenesis NIH Institute-Center: NIAID Seong-In Hyun, Andrea Weisberg and Bernard Moss NIH Research Advisor: Dr. John Mascola Graduate Student Name: Seong-In Hyun Graduate University: Johns Hopkins University NIH Institute-Center: NIAID NIH Research Advisor: Dr. Bernard Moss 58 University Research Advisor: Dr. Jeff DeStefano Contact Guidance During Breast Cancer Cell Metastasis Graduate University: University of Maryland, College Park Song Chen, Rachel Lee, Matt Hourwitz, John Fourkas, Wolfgang Losert and Carole A. Parent 53 Graduate Student Name: Song Chen Elucidating the Role of Progranulin in FTD-associated NIH Institute-Center: NCI Lysosomal Dysfunction NIH Research Advisor: Dr. Carole A. Parent Stewart W. Humble and Michael E. Ward University Research Advisor: Dr. Wolfgang Losert Graduate Student Name: Stewart W. Humble Graduate University: University of Maryland, College Park NIH Institute-Center: NINDS NIH Research Advisor: Dr. Michael E. Ward 59 University Research Advisor: Prof. Richard Wade-Martins Development and Preclinical Evaluation of Live Attenuated Graduate University: University of Oxford, LSUHSC Parainfluenza Virus Vectors expressing Ebola Virus New Orleans Glycoprotein GP as Intranasal Ebola Vaccine Candidates Matthias Lingemann, Xueqiao Liu, Sonja Surman, Bo Liang, 54 Ursula J. Buchholz, Peter L. Collins and Shirin Munir Micro Fabrication of Hard X-ray Compound Refractive Graduate Student Name: Matthias Lingemann Lens Using Nanoprinting Process NIH Institute-Center: NIAID Mona Mirzaeimoghri, Caroline MacCue, Eric Bennett, NIH Research Advisor: Dr. Peter L. Collins Alejandro Morales Martinez, Alireza Panna, Graduate University: Baunschweig University of Technology Bertrand Lucotte, Don DeVoe and Han Wen Graduate Student Name: Mona Mirzaeimoghri NIH Institute-Center: NHLBI NIH Research Advisor: Dr. Han Wen University Research Advisor: Dr. Don DeVoe Graduate University: University of Maryland, College Park NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

60 66 Tubulin Isoform Composition Tunes Microtubule Dynamics Characterization of Btbd7 Expression and Function In Vivo Annapurna Vemu, Joseph Atherton, Jeffrey O. Spector, and In Vitro Carolyn Moores and Antonina Roll-Mecak Joshua W. Collins, William P. Daley and Kenneth M. Yamada Graduate Student Name: Annapurna Vemu Graduate Student Name: Joshua W. Collins NIH Institute-Center: NINDS NIH Institute-Center: NIDCR NIH Research Advisor: Dr. Antonina Roll-Mecak NIH Research Advisor: Kenneth M. Yamada University Research Advisor: Dr. Antonina Roll-Mecak University Research Advisor: Trina Schroer Graduate University: Johns Hopkins University Graduate University: Johns Hopkins University

61 67 The TL1A-DR3 Axis in Immune Complex-Mediated The Anti-gp120 mAb CH58 Recognizes a Not-Fully- Nephritis Processed form of Surface-Expressed Env Nathan Richoz, Françoise Meylan, Taylor K. Farley, Jason Yolitz, Danlan Wei, Donald Van Ryk, Claudia Cicala, Menna R. Clatworthy and Richard M. Siegel Anthony S. Fauci and James Arthos Graduate Student Name: Nathan Richoz Graduate Student Name: Jason Yolitz NIH Institute-Center: NIAMS NIH Institute-Center: NIAID NIH Research Advisor: Dr. Richard M. Siegel NIH Research Advisor: Dr. James Arthos University Research Advisor: Dr. Menna R. Clatworthy Graduate University: Johns Hopkins University Graduate University: University of Cambridge 68 62 Controlling the Ran Pathway at Anaphase Onset Chromatin Remodeling in Motor Neuron Development Ka Chun. Yau, Alexei Arnaoutouv and Mary Dasso Justin Demmerle, Carson J. Miller, Ezequiel Miron, Graduate Student Name: Ka Chun. Yau David Pinto, Ian M. Dobbie, Lothar Schermelleh and NIH Institute-Center: NICHD Todd S. Macfarlan NIH Research Advisor: Dr. Mary Dasso Graduate Student Name: Justin Demmerle University Research Advisor: Dr. K.P. Fung NIH Institute-Center: NICHD Graduate University: The Chinese University of Hong Kong NIH Research Advisor: Dr. Todd S Macfarlan University Research Advisor: Dr. Lothar Schermelleh 69 Graduate University: University of Oxford Elucidating the Mechanism Of Piperaquine Resistance in Plasmodium Falciparum Malaria in Cambodia 63 Megan R. Ansbro, Pharath Lim, Chanaki Amaratunga, Functionality of Tissue-Resident SIV-Specific CD8+ T Cells Hendrik W. van Veen, Marcus C. Lee and Rick M. Fairhurst Carly Elizabeth C. Starke and Jason M. Brenchley Graduate Student Name: Megan R. Ansbro Graduate Student Name: Carly Elizabeth C. Starke NIH Institute-Center: NIAID NIH Institute-Center: NIAID NIH Research Advisor: Dr. Rick Fairhurst NIH Research Advisor: Dr. Jason M. Brenchley University Research Advisor: Dr. Hendrik van Veen Graduate University: Georgetown University Graduate University: University of Cambridge

64 70 Overexpression, Purification, and Characterization of Local Pulsatile Contractions are an Intrinsic Property a Membrane-bound Receptor for PEDF of the Myosin 2A Motor in the Cortical Cytoskeleton of Jeanee Bullock and S. Patricia Becerra Adherent Cells Graduate Student Name: Jeanee Bullock Michelle A. Baird, Neil Billington, Aibing Wang, NIH Institute-Center: NEI Robert S. Adelstein, James R. Sellers, Robert S. Fischer NIH Research Advisor: Dr. S. Patricia Becerra and Clare M. Waterman Graduate University: Georgetown University Graduate Student Name: Michelle A. Baird NIH Institute-Center: NHLBI 65 NIH Research Advisor: Dr. Clare M. Waterman Analysis of Vaccinia Virus Intermediate Transcription University Research Advisor: Dr. Kimberly Stroka Factors and their Orthologs Graduate University: University of Maryland, College Park Carey A. Stuart, Linda S. Wyatt and Bernard Moss Graduate Student Name: Carey A. Stuart NIH Institute-Center: NIAID NIH Research Advisor: Dr. Bernard Moss University Research Advisor: Dr. Jeffrey DeStefano Graduate University: University of Maryland, College Park 23 POSTERS

71 76 Improving Production of Retroviral Vector From PG13 Regulation of Hair-cell Ribbon Synapse Size by Cells for T Cell Therapy Mitochondrial Calcium Stores Sarah, Inwood, Hui Xu, Steven Feldman, Hiu-tung Candy Wong and Katie Kindt Michael J. Betenbaugh and Joseph Shiloach Graduate Student Name: Hiu-tung Candy Wong Graduate Student Name: Sarah Inwood NIH Institute-Center: NIDCD NIH Institute-Center: NIDDK NIH Research Advisor: Katie Kindt NIH Research Advisor: Dr. Joseph Shiloach Graduate University: Johns Hopkins University University Research Advisor: Dr. Michael J. Betenbaugh Graduate University: Johns Hopkins University 77 HLA-A and HLA-B Down-Modulation in HIV-Infected Cells 72 Occurs Late in the Viral Replicative Cycle Frmpd1: A Novel Gene Involved in Rod Photoreceptor Rodrigo Matus-Nicodemos and Daniel Douek Maturation Graduate Student Name: Rodrigo Matus-Nicodemos Christie K. Campla, Jung-Woong Kim, Hyun-Jin Yang, NIH Institute-Center: NIAID Jerome E. Roger, Lijin Dong, Stephanie Halford, NIH Research Advisor: Dr. Richard Koup Sumathi Sekaran and Anand Swaroop Graduate University: Johns Hopkins University Graduate Student Name: Christie K. Campla NIH Institute-Center: NEI 78 NIH Research Advisor: Dr. Anand Swaroop Optineurin Deficiency Causes Paget’s Disease of the Bone University Research Advisor: Dr. Stephanie Halford, by Increasing Osteoclastogenesis Dr. Sumathi Sekaran Sing-Wai Wong, Henry C. Tseng, Wenjing Pan, Graduate University: University of Oxford Ching-Chang Ko and Jennifer Martinez Graduate Student Name: Sing-Wai Wong 73 NIH Institute-Center: NIEHS Distinct Myeloid Cell Subsets Promote Angiogenesis NIH Research Advisor: Dr. Jennifer Martinez and Damaged Tissue Clearance Following Mild University Research Advisor: Dr. Ching-Chang Ko Traumatic Brain Injury Graduate University: University of North Carolina at Chapel Hill Matthew V. Russo and Dorian B. McGavern Graduate Student Name: Matthew V. Russo 79 NIH Institute-Center: NINDS Clinical and Genomic Characterization of a UV-induced NIH Research Advisor: Dr. Dorian B. McGavern BRAF V600E Mouse Model of Human Melanoma University Research Advisor: Dr. Rejji Kuruvilla Helen T. Michael, Chi-Ping Day, Howard Yang, Graduate University: Johns Hopkins University Maxwell Lee and Glenn Merlino Graduate Student Name: Helen T. Michael 74 NIH Institute-Center: NCI Defining the Role of Rabgef1 in Vertebrate Photoreceptors NIH Research Advisor: Glenn Merlino Hyun-Jin Yang, Jung-Woong Kim and Anand Swaroop University Research Advisor: Siba Samal Graduate Student Name: Passley Hargrove Graduate University: University of Maryland, College Park NIH Institute-Center: NEI NIH Research Advisor: Dr. Anand Swaroop 80 University Research Advisor: Dr. Sally Moody Assessing the Physiological Role of Endogenous DNA Graduate University: The George Washington University Double Strand Breaks at Gene Promoters Nicholas Sciascia, Andres Canela and Andre Nussenzweig 75 Graduate Student Name: Nicholas Sciascia Functional Characterization of Genetically Modified NK NIH Institute-Center: NCI Cells Expressing Gain-of-Function CXCR4 Protein NIH Research Advisor: Dr. Andre Nussenzweig Emily Levy, Robert Reger, Mattias Carlsten and University Research Advisor: Dr. Norman Lee Richard Childs Graduate University: The George Washington University Graduate Student Name: Emily Levy NIH Institute-Center: NHLBI NIH Research Advisor: Richard Childs University Research Advisor: Linda Werling Graduate University: The George Washington University

24 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

81 86 A Systems Genetics Approach Reveals a Novel Rnaseh2c- Dopamine Potently Inhibits GABAergic Collateral Immune Response Axis that Affects Metastasis Severity Transmission in the Nucleus Accumbens in Breast Cancer Dennis A. Burke and Veronica A. Alvarez Sarah K. Deasy and Kent W. Hunter Graduate Student Name: Dennis A. Burke Graduate Student Name: Sarah K. Deasy NIH Institute-Center: NIAAA NIH Institute-Center: NCI NIH Research Advisor: Dr. Veronica A. Alvarez NIH Research Advisor: Dr. Kent W. Hunter Graduate University: Brown University University Research Advisor: Dr. Norman Lee Graduate University: The George Washington University 87 Emergence of a Pan-Cancer CpG Island Methylator 82 Phenotype and Unraveling its Underlying Molecular A Novel Mechanism for Growth Cone Motility: In Situ Commonality Live Imaging Suggests that Mesoscopic Organization of Brendan F. Miller, Francisco Sanchez-Vega and Actin Controls Axon Growth and Guidance Laura Elnitski Akanni Clarke, Ramakrishnan Kannan, Phil McQueen, Graduate Student Name: Brendan F. Miller Victor Wang, Tyler Buckley, Hsiao Yu Fang, NIH Institute-Center: NHGRI Stephen Wincovitch, Irina Kuzina and Edward Giniger NIH Research Advisor: Dr. Laura Elnitski Graduate Student Name: Akanni Clarke University Research Advisor: Dr. James Taylor NIH Institute-Center: NINDS Graduate University: Johns Hopkins University NIH Research Advisor: Dr. Edward Giniger University Research Advisor: Dr. Sally Moody 88 Graduate University: The George Washington University Investigating the Role of Fibrinogen and Iron in Inflammatory Demyelination Using Combined High- 83 resolution MRI and Histopathology in Marmoset Single Molecule Analysis of Transcription in Live Cells Experimental Autoimmune Encephalomyelitis Reveals the Gene Regulatory Function of MYC In Vivo Nathanael J. Lee, Seung-Kwon Ha, Nicholas J. Luciano, Simona Patange, Michelle Girvan, David Levens and Emily C. Leibovitch, Jennifer Lefeuvre, Matthew K. Schindler, Daniel R. Larson Pascal Sati, Katerina Akassoglou, Afonso C. Silva, Graduate Student Name: Simona Patange Steven Jacobson and Daniel S. Reich NIH Institute-Center: NCI Graduate Student Name: Nathanael J. Lee NIH Research Advisor: Dr. Daniel R. Larson NIH Institute-Center: NINDS University Research Advisor: Dr. Michelle Girvan NIH Research Advisor: Dr. Daniel S. Reich Graduate University: University of Maryland, College Park University Research Advisor: Dr. Jeffrey Huang Graduate University: Georgetown University 84 WNT Stimulation Dissociates a Frizzled 4 Inactive State 89 Complex with Ga12/13 Combining Local Immunotoxins Targeting Mesothelin Elisa Arthofer, Belma Hot, Julian Petersen, Katerina with CTLA-4 Blockade Synergistically Eradicates Murine Strakova, Stefan Jaeger, Manuel Grundmann, Evi Kostenis, Cancer by Promoting Anti-Cancer Immunity J Silvio Gutkind and Gunnar Schulte Yasmin Leshem, Xiu-fen Liu, Tapan Bera, Masaki Terabe, Graduate Student Name: Elisa Arthofer Jay A Berzofsky, Birgit Bossenmaie, Gerhard Niederfellner, NIH Institute-Center: NICHD James O'Brien, Chin-Hsien Tai, Yoram Reiter and Ira Pastan NIH Research Advisor: Dr. Tamas Balla (Dr. J. Silvio Gutkind) Graduate Student Name: Yasmin Leshem University Research Advisor: Dr. Gunnar Schulte NIH Institute-Center: NCI Graduate University: Karolinska Institute NIH Research Advisor: Dr. Ira Pastan University Research Advisor: Dr. Yoram Reiter 85 Graduate University: Technion-Israel Institute of Technology Predicting Patients Response to Preoperative Chemo-Radiation Therapy in Rectal Cancer Noam Auslander and Thomas Reid Graduate Student Name: Noam Auslander NIH Institute-Center: NCI NIH Research Advisor: Dr. Thomas Reid University Research Advisor: Dr. Eytan Ruppin Graduate University: University of Maryland, College Park

25 POSTERS

90 95 Serotonergic Modulation of the Basolateral Amygdala Comprehensive Analysis of the Dynamics of Aberrant WNT and Fear Learning Signaling on Global Gene Expression and Higher Order Ayesha Sengupta, Marco Bocchio, David Bannerman, Nuclear Structure Marco Capogna, Trevor Sharp and Andrew Holmes Markus Brown, Laura Seaman, Darawalee Wangsa, Graduate Student Name: Ayesha Sengupta Haiming Chen, Yue Hu, Indika Rajapakse and Thomas Ried NIH Institute-Center: NIAAA Graduate Student Name: Markus Brown NIH Research Advisor: Dr. Andrew Holmes NIH Institute-Center: NCI University Research Advisor: Prof. Trevor Sharp, NIH Research Advisor: Dr. Thomas Ried Prof. David Bannerman University Research Advisor: Dr. Eytan Ruppin Graduate University: University of Oxford Graduate University: University of Maryland, College Park

91 96 Mutant IL-7Ra and Mutant NRAs are Sufficient to Induce The Genetic Basis of Photoreceptor Synaptic Terminal T-Cell Acute Lymphoblastic Leukemia/Lymphoma Structure Sarah D. Cramer, Julie A. Hixon, Caroline Andrews, D. Thad Whitaker, Passley Hargrove, Hannah Fann, Ross J. Porter, Gisele Rodrigues, Xiaolin Wu, Tim Back, Amal Alsufyani, Matthew J. Brooks, Soo-Young Kim Kelli Czarra, Helen Michael, Maggie Cam, Emilee and Anand Swaroop Senkevitch, Peter D. Aplan, Wenqing Li and Scott K. Durum Graduate Student Name: D. Thad Whitaker Graduate Student Name: Sarah D. Cramer NIH Institute-Center: NEI NIH Institute-Center: NCI NIH Research Advisor: Dr. Anand Swaroop NIH Research Advisor: Dr. Scott K. Durum University Research Advisor: Dr. Michael Smotherman University Research Advisor: Dr. Siba Samal Graduate University: Texas A&M University Graduate University: University of Maryland, College Park 97 92 Using Variation Graphs to Improve Somatic Structural Astrocytes Contribute to Homeostatic Control of Variant Detection Breathing at Rest and During Exercise Erik Garrison, Richard Durbin and Stephen Chanock Shahriar Sheikhbahaei, Egor Turovsky, Sergey Kasparov, Graduate Student Name: Eric T. Dawson Jeffrey C. Smith and Alexander V. Gourine NIH Institute-Center: NCI-DCEG Graduate Student Name: Shahriar SheikhBahaei NIH Research Advisor: Dr. Stephen Chanock NIH Institute-Center: NINDS University Research Advisor: Prof. Richard Durbin NIH Research Advisor: Dr. Jeffrey C. Smith Graduate University: University of Cambridge University Research Advisor: Prof. Alexader V. Gourine Graduate University: University College London 98 Permeabilization-Free Antibody Labeling of the Olfactory 93 Bulb for Correlative Serial Block-Face Scanning Electron A SRM Based Targeted Proteomics Strategy to Quantify Microscopy Potential Markers of TKI Response in Lung Cancer Kara Fulton and Kevin L. Briggman Shivangi Awasthi, Tapan Maity and Xu Zhang Graduate Student Name: Kara A. Fulton Graduate Student Name: Shivangi Awasthi NIH Institute-Center: NINDS NIH Institute-Center: NCI NIH Research Advisor: Dr. Kevin L. Briggman NIH Research Advisor: Dr. Udayan Guha Graduate University: Brown University University Research Advisor: Dr. David R. Goodlett Graduate University: University of Maryland, Baltimore 99 Finding Hidden SNPs in Bushmen Genome 94 Methylation Data An Integral Membrane Phospholipid Phosphate Brenna A. LaBarre and Laura L. Elnitski Phosphatase, PLPPR1, Overcomes Chondroitin Sulfate Graduate Student Name: Brenna A. LaBarre Inhibition and Regulates Neuronal Plasticity NIH Institute-Center: NHGRI Chinyere Agbaegbu Iweka, Panpan Yu, Caitlin Mencio, NIH Research Advisor: Dr. Laura L. Elnitski Sharada Tilve, Hero Katagiri and Herbert M. Geller Graduate University: Boston University Graduate Student Name: Chinyere Agbaegbu Iweka NIH Institute-Center: NHLBI NIH Research Advisor: Dr. Herbert M Geller University Research Advisor: Dr. Jeffrey Urbach Graduate University: Georgetown University 26 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2017

100 104 Differences in Phosphorylation of Neuroligins: 4X vs. 4Y Spatio-Temporal Alterations in Working Memory- Thien A. Nguyen, Michael A. Bemben, Yan Li and Related Neural Activity in Schizophrenia while On and Off Katherine W. Roche Antipsychotic Medication Graduate Student Name: Thien A. Nguyen Dani Y. Rubinstein, Daniel P. Eisenberg, Frederick W. Carver, NIH Institute-Center: NINDS Tom Holroyd, Daniel R. Weinberger, Jose A. Apud, NIH Research Advisor: Dr. Katherine Roche Richard Coppola and Karen F. Berman University Research Advisor: Dr. Daniel Pak Graduate Student Name: Dani Y. Rubinstein Graduate University: Georgetown University NIH Institute-Center: NIMH NIH Research Advisor: Dr. Karen F. Berman 101 University Research Advisor: Dr. David L. Sheinberg Acute Inflammation Effects of Personal Exposures Graduate University: Brown University to Fine-Particulate Air Pollution may be Mediated by Methylation 105 Cuicui Wang, Renjie Chen, Min Shi, Jing Cai, Jingjin Shi, Sources of Intracellular Calcium Transients and Amplitude Changyuan Yang, Huichu Li, Zhijing Lin, Xia Meng, Modulation in the Respiratory Pre-Bötzinger Complex Cong Liu, Yue Niu, Yongjie Xia, Zhuohui Zhao, Haidong Kan Ryan S. Phillip and Jeffrey Smith and Clarice R. Weinberg Graduate Student Name: Ryan S. Phillips Graduate Student Name: Cuicui Wang NIH Institute-Center: NINDS NIH Institute-Center: NIEHS NIH Research Advisor: Dr. Jeffrey Smith NIH Research Advisor: Dr. Clarice R. Weinberg University Research Advisor: Dr. Bill Hersman University Research Advisor: Dr. Haidong Kan Graduate University: University of New Hampshire Graduate University: Fudan Univerisity 106 102 Pleasing Astrocytes: What is the Secret of OECs? Multi-channel MRI Array Coils for Imaging the Brain Aybike Saglam and Susan Wray and Spinal Cord of Common Marmosets Graduate Student Name: Aybike Saglam Wen-Yang Chiang, Cecil Chern-Chyi Yen, Jennifer Lefeuvre, NIH Institute-Center: NINDS Nick Luciano, Joseph Murphy-Boesch, Mary McDougall, NIH Research Advisor: Dr. Susan Wray Daniel Reich, Pascal Sati and Afonso Silva University Research Advisor: Dr. Ricardo Araneda Graduate Student Name: Wen-Yang Chiang Graduate University: University of Maryland, College Park NIH Institute-Center: NINDS NIH Research Advisor: Dr. Afonso Silva 107 University Research Advisor: Dr. Mary McDougall Packaging and Horizontal Transfer of Cellular DNA by Graduate University: Texas A&M University Animal Viruses Michael J. Tisza, Valery Bliskovsky, Diana V. Pastrana 103 and Christopher B. Buck Exploring Information Transmission in Gene Networks Graduate Student Name: Michael J. Tisza Using Stochastic Simulation and Machine Learning NIH Institute-Center: NCI Kyemyung Park, Thorsten Prustel, Manikandan Narayanan, NIH Research Advisor: Dr. Christopher B. Buck Yong Lu, Andrew J. Martins and John S. Tsang Graduate University: Johns Hopkins University Graduate Student Name: Kyemyung Park NIH Institute-Center: NIAID 108 NIH Research Advisor: Dr. John S. Tsang No Change in ABC Transporter Expression Between University Research Advisor: Dr. Doron Levy Sclerotic and Non-Sclerotic Drug Resistant Epilepsy Tissue Graduate University: University of Maryland, College Park Lora D. Weidner, Pavitra Kannan, Nicholas Mitsios, Matthew D. Hall, William H. Theodore, Robert B. Innis and Jan Mulder Graduate Student Name: Lora D. Weidner NIH Institute-Center: NIMH NIH Research Advisor: Dr. Robert Innis University Research Advisor: Dr. Jan Mulder Graduate University: Karolinska Institutet

27 POSTERS

109 117 Hemodynamic Changes During N-backTask Body Composition and Mortality Among Adults with Hadis Dashtestani, Afrooz Anderson Azari, Nader Shahni Colorectal Cancer: the NIH-AARP Diet and Health Study Karamzadeh and Amir Gandjbakhche Maria Rosario B. Aguiluz-Abunto, Didier Chalhoub Graduate Student Name: Hadis Dashtestani and Tamara Harris NIH Institute-Center: NICHD Graduate Student Name: Maria Rosario B. Aguiluz-Abunto NIH Research Advisor: Dr. Amir Gandjbakhche NIH Institute-Center: NIA University Research Advisor: Dr. Milton Halem NIH Research Advisor: Dr. Tamara Harris Graduate University: University of Maryland, Baltimore County University Research Advisor: Dr. Didier Chalhoub Graduate University: University of Pittsburgh Graduate 110 School of Public Health Cell-Specific Differential Expression of ErbB4 Isoforms in Brain Detected by BaseScope – a Novel 119 In Situ Hybridization Technique Parallel Implementation of P21 Periodic Boundary Larissa M. Erben, Ming-Xiao He, Mindy Wang, Emily Park Condition in CHARMM and Andres Buonanno Samar Samarjeet, Thomas Woolf and Bernard Brooks Graduate Student Name: Larissa M. Erben Graduate Student Name: Samar Samarjeet NIH Institute-Center: NICHD NIH Institute-Center: NHLBI NIH Research Advisor: Dr. Andres Buonanno NIH Research Advisor: Dr. Bernard Brooks University Research Advisor: Prof. Dr. Andreas Zimmer University Research Advisor: Dr. Tom Woolf Graduate University: University of Bonn Graduate University: Johns Hopkins University, School of Medicine 111 A Neuroanatomic Atlas of the Larval Zebrafish Brain Derived from Computational Analysis of Gene Expression Gregory D. Marquart, Sinisa Pajevic, Alison Heffer and Igor B. Dawid Graduate Student Name: Gregory D. Marquart NIH Institute-Center: NICHD NIH Research Advisor: Dr. Harold A. Burgess University Research Advisor: Dr. Jens Herberholz Graduate University: University of Maryland, College Park

113 Oscillations and Neuronal Avalanche Shape in Spontaneous Cortical Activity Shan Yu and Dietmar Plenz Graduate Student Name: Stephanie R. Miller NIH Institute-Center: NIMH NIH Research Advisor: Dr. Dietmar Plenz University Research Advisor: Dr. Rajarshi Roy Graduate University: University of Maryland, College Park

115 Cdk5 Dysfunction Increases the Intrinsic Rate of Aging Josh Spurrier, Arvind Shukla and Ed Giniger Graduate Student Name: Josh Spurrier NIH Institute-Center: NINDS NIH Research Advisor: Dr. Ed Giniger University Research Advisor: Dr. Haiqing Zhao Graduate University: Johns Hopkins University

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