Table 3. Genes Bound by NF-Κb in U937 Cells
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HCST (NM 001007469) Human Recombinant Protein Product Data
OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for TP319253 HCST (NM_001007469) Human Recombinant Protein Product data: Product Type: Recombinant Proteins Description: Recombinant protein of human hematopoietic cell signal transducer (HCST), transcript variant 2 Species: Human Expression Host: HEK293T Tag: C-Myc/DDK Predicted MW: 7.3 kDa Concentration: >50 ug/mL as determined by microplate BCA method Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. Storage: Store at -80°C. Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. RefSeq: NP_001007470 Locus ID: 10870 UniProt ID: Q9UBK5 RefSeq Size: 521 Cytogenetics: 19q13.12 RefSeq ORF: 279 Synonyms: DAP10; KAP10; PIK3AP This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 HCST (NM_001007469) Human Recombinant Protein – TP319253 Summary: This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. -
An Order Estimation Based Approach to Identify Response Genes
AN ORDER ESTIMATION BASED APPROACH TO IDENTIFY RESPONSE GENES FOR MICRO ARRAY TIME COURSE DATA A Thesis Presented to The Faculty of Graduate Studies of The University of Guelph by ZHIHENG LU In partial fulfilment of requirements for the degree of Doctor of Philosophy September, 2008 © Zhiheng Lu, 2008 Library and Bibliotheque et 1*1 Archives Canada Archives Canada Published Heritage Direction du Branch Patrimoine de I'edition 395 Wellington Street 395, rue Wellington Ottawa ON K1A0N4 Ottawa ON K1A0N4 Canada Canada Your file Votre reference ISBN: 978-0-494-47605-5 Our file Notre reference ISBN: 978-0-494-47605-5 NOTICE: AVIS: The author has granted a non L'auteur a accorde une licence non exclusive exclusive license allowing Library permettant a la Bibliotheque et Archives and Archives Canada to reproduce, Canada de reproduire, publier, archiver, publish, archive, preserve, conserve, sauvegarder, conserver, transmettre au public communicate to the public by par telecommunication ou par Plntemet, prefer, telecommunication or on the Internet, distribuer et vendre des theses partout dans loan, distribute and sell theses le monde, a des fins commerciales ou autres, worldwide, for commercial or non sur support microforme, papier, electronique commercial purposes, in microform, et/ou autres formats. paper, electronic and/or any other formats. The author retains copyright L'auteur conserve la propriete du droit d'auteur ownership and moral rights in et des droits moraux qui protege cette these. this thesis. Neither the thesis Ni la these ni des extraits substantiels de nor substantial extracts from it celle-ci ne doivent etre imprimes ou autrement may be printed or otherwise reproduits sans son autorisation. -
Genetic Correlations Reveal the Shared Genetic Architecture of Transcription in Human Peripheral Blood
Hemani, G. (2017). Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood. Nature Communications, 8, [483]. https://doi.org/10.1038/s41467-017-00473- z Publisher's PDF, also known as Version of record License (if available): CC BY Link to published version (if available): 10.1038/s41467-017-00473-z Link to publication record in Explore Bristol Research PDF-document This is the final published version of the article (version of record). It first appeared online via Nature Publishing Group at https://www.nature.com/articles/s41467-017-00473-z . Please refer to any applicable terms of use of the publisher. University of Bristol - Explore Bristol Research General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/red/research-policy/pure/user-guides/ebr-terms/ ARTICLE DOI: 10.1038/s41467-017-00473-z OPEN Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood Samuel W. Lukowski 1, Luke R. Lloyd-Jones1,2, Alexander Holloway2, Holger Kirsten3,4, Gibran Hemani 5,6, Jian Yang 1,2, Kerrin Small 7, Jing Zhao8, Andres Metspalu9, Emmanouil T. Dermitzakis10, Greg Gibson 8, Timothy D. Spector7, Joachim Thiery4,11, Markus Scholz 3,4, Grant W. Montgomery1,12, Tonu Esko 9, Peter M. Visscher 1,2 & Joseph E. Powell1,2 Transcript co-expression is regulated by a combination of shared genetic and environmental factors. Here, we estimate the proportion of co-expression that is due to shared genetic variance. -
Valproic Acid Reversed Pathologic Endothelial Cell Gene Expression Profile Associated with Ischemia– Reperfusion Injury in a Swine Hemorrhagic Shock Model
From the Peripheral Vascular Surgery Society Valproic acid reversed pathologic endothelial cell gene expression profile associated with ischemia– reperfusion injury in a swine hemorrhagic shock model Marlin Wayne Causey, MD,a Shashikumar Salgar, PhD,b Niten Singh, MD,a Matthew Martin, MD,a and Jonathan D. Stallings, PhD,b Tacoma, Wash Background: Vascular endothelial cells serve as the first line of defense for end organs after ischemia and reperfusion injuries. The full etiology of this dysfunction is poorly understood, and valproic acid (VPA) has proven to be beneficial after traumatic injury. The purpose of this study was to determine the mechanism of action through which VPA exerts its beneficial effects. Methods: Sixteen Yorkshire swine underwent a standardized protocol for an ischemia–reperfusion injury through received (6 ؍ hemorrhage and a supraceliac cross-clamp with ensuing 6-hour resuscitation. The experimental swine (n Aortic .(5 ؍ and injury-control models (n (5 ؍ VPA at cross-clamp application and were compared with sham (n endothelium was harvested, and microarray analysis was performed along with a functional clustering analysis with gene transcript validation using relative quantitative polymerase chain reaction. Results: Clinical comparison of experimental swine matched for sex, weight, and length demonstrated that VPA significantly decreased resuscitative requirements, with improved hemodynamics and physiologic laboratory measure- ments. Six transcript profiles from the VPA treatment were compared with the 1536 gene transcripts (529 up and 1007 down) from sham and injury-control swine. Microarray analysis and a Database for Annotation, Visualization and Integrated Discovery functional pathway analysis approach identified biologic processes associated with pathologic vascular endothelial function, specifically through functional cluster pathways involving apoptosis/cell death and angiogenesis/vascular development, with five specific genes (THBS1, TNFRSF12A, ANGPTL4, RHOB, and RTN4) identified as members of both functional clusters. -
Plasma Cells in Vitro Generation of Long-Lived Human
Downloaded from http://www.jimmunol.org/ by guest on September 24, 2021 is online at: average * The Journal of Immunology , 32 of which you can access for free at: 2012; 189:5773-5785; Prepublished online 16 from submission to initial decision 4 weeks from acceptance to publication November 2012; doi: 10.4049/jimmunol.1103720 http://www.jimmunol.org/content/189/12/5773 In Vitro Generation of Long-lived Human Plasma Cells Mario Cocco, Sophie Stephenson, Matthew A. Care, Darren Newton, Nicholas A. Barnes, Adam Davison, Andy Rawstron, David R. Westhead, Gina M. Doody and Reuben M. Tooze J Immunol cites 65 articles Submit online. Every submission reviewed by practicing scientists ? is published twice each month by Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts http://jimmunol.org/subscription http://www.jimmunol.org/content/suppl/2012/11/16/jimmunol.110372 0.DC1 This article http://www.jimmunol.org/content/189/12/5773.full#ref-list-1 Information about subscribing to The JI No Triage! Fast Publication! Rapid Reviews! 30 days* Why • • • Material References Permissions Email Alerts Subscription Supplementary The Journal of Immunology The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2012 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. This information is current as of September 24, 2021. The Journal of Immunology In Vitro Generation of Long-lived Human Plasma Cells Mario Cocco,*,1 Sophie Stephenson,*,1 Matthew A. -
Role and Regulation of the P53-Homolog P73 in the Transformation of Normal Human Fibroblasts
Role and regulation of the p53-homolog p73 in the transformation of normal human fibroblasts Dissertation zur Erlangung des naturwissenschaftlichen Doktorgrades der Bayerischen Julius-Maximilians-Universität Würzburg vorgelegt von Lars Hofmann aus Aschaffenburg Würzburg 2007 Eingereicht am Mitglieder der Promotionskommission: Vorsitzender: Prof. Dr. Dr. Martin J. Müller Gutachter: Prof. Dr. Michael P. Schön Gutachter : Prof. Dr. Georg Krohne Tag des Promotionskolloquiums: Doktorurkunde ausgehändigt am Erklärung Hiermit erkläre ich, dass ich die vorliegende Arbeit selbständig angefertigt und keine anderen als die angegebenen Hilfsmittel und Quellen verwendet habe. Diese Arbeit wurde weder in gleicher noch in ähnlicher Form in einem anderen Prüfungsverfahren vorgelegt. Ich habe früher, außer den mit dem Zulassungsgesuch urkundlichen Graden, keine weiteren akademischen Grade erworben und zu erwerben gesucht. Würzburg, Lars Hofmann Content SUMMARY ................................................................................................................ IV ZUSAMMENFASSUNG ............................................................................................. V 1. INTRODUCTION ................................................................................................. 1 1.1. Molecular basics of cancer .......................................................................................... 1 1.2. Early research on tumorigenesis ................................................................................. 3 1.3. Developing -
Gene Discovery in Developmental Neuropsychiatric Disorders : Clues from Chromosomal Rearrangements Thomas V
Yale University EliScholar – A Digital Platform for Scholarly Publishing at Yale Yale Medicine Thesis Digital Library School of Medicine 2005 Gene discovery in developmental neuropsychiatric disorders : clues from chromosomal rearrangements Thomas V. Fernandez Yale University Follow this and additional works at: http://elischolar.library.yale.edu/ymtdl Recommended Citation Fernandez, Thomas V., "Gene discovery in developmental neuropsychiatric disorders : clues from chromosomal rearrangements" (2005). Yale Medicine Thesis Digital Library. 2578. http://elischolar.library.yale.edu/ymtdl/2578 This Open Access Thesis is brought to you for free and open access by the School of Medicine at EliScholar – A Digital Platform for Scholarly Publishing at Yale. It has been accepted for inclusion in Yale Medicine Thesis Digital Library by an authorized administrator of EliScholar – A Digital Platform for Scholarly Publishing at Yale. For more information, please contact [email protected]. YALE UNIVERSITY CUSHING/WHITNEY MEDICAL LIBRARY Permission to photocopy or microfilm processing of this thesis for the purpose of individual scholarly consultation or reference is hereby granted by the author. This permission is not to be interpreted as affecting publication of this work or otherwise placing it in the public domain, and the author reserves all rights of ownership guaranteed under common law protection of unpublished manuscripts. Digitized by the Internet Archive in 2017 with funding from The National Endowment for the Humanities and the Arcadia Fund https://archive.org/details/genediscoveryindOOfern Gene discovery in developmental neuropsychiatric disorders: Clues from chromosomal rearrangements A Thesis Submitted to the Yale University School of Medicine In Partial Fulfillment of the Requirements for the Degree of Doctor of Medicine by Thomas V. -
Supplementary Table 3 Gene Microarray Analysis: PRL+E2 Vs
Supplementary Table 3 Gene microarray analysis: PRL+E2 vs. control ID1 Field1 ID Symbol Name M Fold P Value 69 15562 206115_at EGR3 early growth response 3 2,36 5,13 4,51E-06 56 41486 232231_at RUNX2 runt-related transcription factor 2 2,01 4,02 6,78E-07 41 36660 227404_s_at EGR1 early growth response 1 1,99 3,97 2,20E-04 396 54249 36711_at MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F 1,92 3,79 7,54E-04 (avian) 42 13670 204222_s_at GLIPR1 GLI pathogenesis-related 1 (glioma) 1,91 3,76 2,20E-04 65 11080 201631_s_at IER3 immediate early response 3 1,81 3,50 3,50E-06 101 36952 227697_at SOCS3 suppressor of cytokine signaling 3 1,76 3,38 4,71E-05 16 15514 206067_s_at WT1 Wilms tumor 1 1,74 3,34 1,87E-04 171 47873 238623_at NA NA 1,72 3,30 1,10E-04 600 14687 205239_at AREG amphiregulin (schwannoma-derived growth factor) 1,71 3,26 1,51E-03 256 36997 227742_at CLIC6 chloride intracellular channel 6 1,69 3,23 3,52E-04 14 15038 205590_at RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 1,68 3,20 1,87E-04 55 33237 223961_s_at CISH cytokine inducible SH2-containing protein 1,67 3,19 6,49E-07 78 32152 222872_x_at OBFC2A oligonucleotide/oligosaccharide-binding fold containing 2A 1,66 3,15 1,23E-05 1969 32201 222921_s_at HEY2 hairy/enhancer-of-split related with YRPW motif 2 1,64 3,12 1,78E-02 122 13463 204015_s_at DUSP4 dual specificity phosphatase 4 1,61 3,06 5,97E-05 173 36466 227210_at NA NA 1,60 3,04 1,10E-04 117 40525 231270_at CA13 carbonic anhydrase XIII 1,59 3,02 5,62E-05 81 42339 233085_s_at OBFC2A oligonucleotide/oligosaccharide-binding -
Computational Methods for Breast Cancer Diagnosis, Prognosis, and Treatment Prediction
Computational Methods for Breast Cancer Diagnosis, Prognosis, and Treatment Prediction By Ashish Saini Bachelor of IT (Honours) Deakin University, Australia Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy Deakin University August, 2014 Acknowledgements I would like to express my sincere gratitude to my principle supervisor Prof. Wanlei Zhou and associate supervisor Dr. Jingyu Hou for their constant support, valuable suggestions and invaluable guidance. I have learnt so much from them, including the research process, how to write papers, the publication process for papers, teaching methods, and much more. Without their everlasting support, inspiring enthusiasm, and encouragement, this thesis could not have been completed. I feel fortunate to work with such wonderful supervisors and will always be grateful for their supervision and encouragement for the rest of my life. I would also like to thank the academic and general research staff of the School of Information Technology, Deakin University, Australia. They are Dr. Jingyu Hou for offering the chance to gain teaching experience, Mr. Nghia Dang for IT support, and Ms. Alison Carr, Ms. Lauren Fisher and Ms. Kathy Giulieri for their general management and secretarial work which enabled me to attend academic conferences and workshops. I would also like to thank my research colleagues who helped me in my research and daily life in general. They are Dr. Sheng Wen, Dr. Tianqing Zhu, Mr. Faizal Raid-ud-Din, Dr. Longxiang Gao, Mr. Yongqing Jiang, and Mr. Biplob Ray. For those whose names are not mentioned here, I have not forgotten you the help you have given me. -
Untersuchungen Zum Einfluss Von Infrarot-A Strahlung Auf Die Genexpression in Humanen Dermalen Fibroblasten
Untersuchungen zum Einfluss von Infrarot-A Strahlung auf die Genexpression in humanen dermalen Fibroblasten Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakult¨at der Heinrich-Heine-Universit¨at Dusseldorf¨ vorgelegt von Christian Calles aus Dusseldorf¨ Dusseldorf,¨ Oktober 2009 Aus dem Institut fur¨ umweltmedizinische Forschung an der Heinrich-Heine-Universit¨at Dusseldorf¨ gGmbH. Gedruckt mit der Genehmigung der Mathematisch-Naturwissen- schaftlichen Fakult¨at der Heinrich-Heine-Universit¨at Dusseldorf.¨ Referent: Prof. Dr. J. Krutmann Koreferent: Prof. Dr. R. Wagner Tag der mundlichen¨ Prufung:¨ 10. Dezember 2009 Danksagung Bei Prof. Dr. J. Krutmann m¨ochte ich mich dafur¨ bedanken, dass er mir diese Arbeit am Institut fur¨ umweltmedizinische Forschung erm¨oglichte, bei Peet Schroeder fur¨ die super Betreuung uber¨ die ganze Zeit und der ganzen Arbeitsgruppe fur¨ das nun seit Jahren anhaltende erstklassige Arbeitsklima. Prof. Dr. R. Wagner danke ich fur¨ die bereitwillige Ubernahme¨ des Koreferates. Marc, Bianca, Fina und Tereza danke ich fur¨ Ihren Einsatz beim Korrekturlesen und Jochen fur¨ die Unterstutzung¨ in der ein oder anderen (bio)-informatischen Frage und den Tips zu LATEX. 4 Inhaltsverzeichnis 1 Einleitung 1 1.1 Infrarot A (IRA) und das solare Spektrum . 1 1.2 Photobiologische Effekte nicht-ionisierender Strahlung . 2 1.3 Aufbau & Struktur der menschlichen Haut . 4 1.3.1 Die extrazellul¨are Matrix (ECM) der Dermis und die Rolle von Ma- trixmetalloproteinasen . 5 1.4 Intrinsische Hautalterung . 8 1.5 Extrinsische Hautalterung durch Lichteinflusse:¨ Photoaging . 8 1.5.1 Biologische Effekte von Infrarotstrahlung in der menschlichen Haut 9 1.6 Bedeutung von reaktiven Sauerstoffspezies in lichtinduzierten Alterungs- prozessen . 11 1.7 Fragestellung . -
Human Social Genomics in the Multi-Ethnic Study of Atherosclerosis
Getting “Under the Skin”: Human Social Genomics in the Multi-Ethnic Study of Atherosclerosis by Kristen Monét Brown A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Epidemiological Science) in the University of Michigan 2017 Doctoral Committee: Professor Ana V. Diez-Roux, Co-Chair, Drexel University Professor Sharon R. Kardia, Co-Chair Professor Bhramar Mukherjee Assistant Professor Belinda Needham Assistant Professor Jennifer A. Smith © Kristen Monét Brown, 2017 [email protected] ORCID iD: 0000-0002-9955-0568 Dedication I dedicate this dissertation to my grandmother, Gertrude Delores Hampton. Nanny, no one wanted to see me become “Dr. Brown” more than you. I know that you are standing over the bannister of heaven smiling and beaming with pride. I love you more than my words could ever fully express. ii Acknowledgements First, I give honor to God, who is the head of my life. Truly, without Him, none of this would be possible. Countless times throughout this doctoral journey I have relied my favorite scripture, “And we know that all things work together for good, to them that love God, to them who are called according to His purpose (Romans 8:28).” Secondly, I acknowledge my parents, James and Marilyn Brown. From an early age, you two instilled in me the value of education and have been my biggest cheerleaders throughout my entire life. I thank you for your unconditional love, encouragement, sacrifices, and support. I would not be here today without you. I truly thank God that out of the all of the people in the world that He could have chosen to be my parents, that He chose the two of you. -
Reference Transcriptomes of Porcine Peripheral Immune Cells Created Through Bulk and Single-Cell RNA Sequencing
bioRxiv preprint doi: https://doi.org/10.1101/2021.04.02.438107; this version posted April 4, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license. 1 Reference transcriptomes of porcine peripheral immune cells created through bulk and 2 single-cell RNA sequencing 3 4 Juber Herrera-Uribe1†, Jayne E. Wiarda2,3,4†, Sathesh K. Sivasankaran2,5, Lance Daharsh1, Haibo 5 Liu1, Kristen A. Byrne2, Timothy P.L .Smith6, Joan K. Lunney7, CrystaL L. Loving2‡*, 6 Christopher K. Tuggle1‡* 7 8 1 Department of AnimaL Science, Iowa State University, Ames, IA, USA. 9 2 Food Safety and Enteric Pathogens Research Unit, NationaL AnimaL Disease Center, 10 AgriculturaL Research Service, United States Department of Agriculture, Ames, IA, USA 11 3 Immunobiology Graduate Program, Iowa State University, Ames, IA, USA 12 4 Oak Ridge Institute for Science and Education, AgriculturaL Research Service Participation 13 Program, Oak Ridge, TN, USA 14 5 Genome Informatics FaciLity, Iowa State University, Ames, IA, USA 15 6 USDA, ARS, U.S. Meat AnimaL Research Center, Clay Center, Nebraska, USA 16 7 USDA-ARS, BeLtsviLLe AgriculturaL Research Center, AnimaL Parasitic Diseases Laboratory, 17 BeLtsviLLe, MD, USA. 18 † These authors have contributed equaLLy to this work and share first authorshiP 19 ‡ These authors have contributed equaLLy to this work and share senior and last authorshiP 20 *Correspondence: 21 Corresponding authors: [email protected], [email protected] 22 23 Keywords: Pig, immune ceLLs, transcriptome, Single-ceLL RNA-seq, bulkRNA-seq, FAANG.