Supplemental Table 2 : Description

Symbol Gene Name Molecular Function Canonical Pathway Description Biological process

AHDC1 AT-hook DNA binding DNA binding _ Gene mutations: Xia-Gibbs syndrome _ motif containing 1

AQP2 Aquaporin 2 actin binding; channel activity; Apelin endothelial Water chanel from kidney collecting tubule. actin filament depolymerization; glycerol transmembrane signaling pathway; Gene mutations: nephrogenic diabetes insipidus apoptotic process; excretion; cell transporter activity eNOS signaling homeostatis; glycerol transport

BAIAP3 BAI1 associated protein calcium ion binding; phospholipid _ P53-target gene encodes brain-specific angiogenesis exocytosis; G-protein coupled receptor 3 binding; protein binding; syntaxin inhibitor. Two C2 domains from involved in signaling pathway; regulation of binding signal transduction or membrane trafficking synaptic transmission; retrograde transport

BLK BLK proto-oncogene, ATP-binding; kinase activity; PI3K Signaling in B Involved in b cell proliferation and differentiation B cell receptor signaling pathway; cell Src family tyrosine protein binding; transferase lymphocytes; Tec and has a role in B-cell receptor signaling and B-cell differentiation and proliferation; kinase activity kinase signaling development innate immune response; intracellular signal transduction

DAAM1 Dishevelled associated actin binding; identical protein PCP pathway; Role of Involved in cell motility, adhesion, cytokinesis, actin cytoskeleton organization; Wnt activator of binding; protein binding; Rho macrophages; reorganization of the actin cytoskeleton, cell polarity and receptor signalling pathway morphogenesis 1 GTPase binding Fibroblasts and movement (activated during Wnt/Fz signalling) and Endothelial Cells in regulates cell growth Rheumatoid Arthritis

EBF1 Early B cell factor 1 RNA polymerase II core B cell receptor Transcriptional activator which recognizes variations multicellular organismal promoter proximal region signalling; IL-17 of the palindromic sequence 5- development; positive regulation of sequence-specific DNA binding; Signaling pathway ATTCCCNNGGAATT-3. Named Transcription transcription; DNA-dependent; transcription factor involved in factor COE1 and activates target positive regulation of transcription positive regulation of from RNA polymerase II promoter transcription activity; DNA binding

EIF4E2 Eukaryotic translation RNA binding; translation initiation _ Recognizes and binds the 7-methylguanosine-containing negative regulation of translation initiation factor 4E factor activity; ubiquitin protein mRNA cap during an early step in the initiation. Acts as family member 2 ligase binding a repressor of translation initiation

EMX2 Empty spiracles sequence-specific DNA binding _ Known expressed in three tissues: dorsal brain development; multicellular homeobox 2 RNA polymerase II transcription telencephalon, olfactory neuroepithelium, and epithelial organismal development; neuron factor activity urogenetial system differentiation; regulation of gene expression

FAM149B1 Family with sequence _ _ _ _ similarity 149 member B1

FLT1 Fms related tyrosine ATP binding; vascular endothelial eNOS signalling; IL-8 Binds to VEGFR-1, VEGFR-B and placental growth angiogenesis; blood vessel kinase 1 growth factor-activated receptor signaling; NF-kB factor and plays an important role in angiogenesis and morphogenesis; cell differentiation; cell activity; kinase activity; signalling; Nitric oxide vasculogenesis. Expression of this receptor is found in migration; cell proliferation; cellular transferase activity; protein signalling in the vascular endothelial cells and peripheral blood response to vascular endothelial growth binding; transmembrane signalling cardiovascular system; monocytes factor stimulus; monocyte chemotaxis; receptor activity PTEN signalling; negative regulation of apoptotic process; STAT3 pathway; negative regulation of signal VEGF family ligand- transduction; positive regulation of receptor interactions; kinase activity; vascular endothelial VEGF signaling growth factor signalling pathway

FOXD4L3 Forhead box D4 like 6 protein binding; sequence-specific _ _ anatomical structure morphogenesis; cell DNA binding; sequence-sequence differentiation; regulation of DNA binding RNA polymerase II transcription from RNA polymerase II transcription factor activity promoter

GPC6 Glypican 6 heparan sulfate proteoglycan _ The glypicans comprise a family of cell migration; glycosaminoglycan binding; protein binding glycosylphosphatidylinositol-anchored heparin sulfate biosynthetic process; regulation of signal proteoglycans, are implicated in the control of cell transduction; retinoid metabolic process; growth and cell division. Putative cell surface coreceptor Wnt receptor signalling pathway for growth factors, extracellular matrix proteins, proteases and anti-proteases.

HMGA2 High mobility group 5’-deoxyribose-5-phosphate lyase Regulation of the Belongs to the non-histone chromosomal high mobility cell division; chromatin organization; AT-hook 2 activity; AT DNA binding; C2H2 Epithelial- group (HMG) protein family, as architectural factors and DNA damage response; endodermal / zinc finger domain binding; cAMP Mesenchymal are essential components of the enhancesome. This mesodermal cell differentiation; response element binding; DNA- Transition Pathway protein contains structural DNA-binding domains and epithelial to mesenchymal transition; dependent protein kinase activity; may act as a transcriptional regulating factor. Is involved negative regulation of retroviral MH1 domain binding; in adipogenesis and mesenchymal differentiation. replication; negative regulation of transcription regulation apoptotic process; negative regulation of transcription; positive regulation of angiogenesis

IGLV8-61 Immunoglobulin Antigen binding _ Participates in the antigen recognition. Membrane- adaptive immune response; lambda variable 8-61 bound antibodies or secreted glycoproteins produced immunoglobulin production by B lymphocytes. In the humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.

LOC100131 Uncharacterized _ _ _ _ 655

MCMBP Minichromosome chromatin binding; protein binding _ Encodes a protein which is a component of the cell cycle; cell division; DNA-dependent maintenance complex hexameric minichromosome maintenance (MCM) DNA replication binding protein complex which regulates initiation and elongation of DNA

MEI4 Meiotic double- Protein binding _ Required for DNA double-strand breaks formation in DNA recombination; meiotic cell cycle; stranded break unsynapsed regions during meiotic recombination meiotic DNA double-strand break formation protein 4 formation, synapsis

MIR3677 microRNA 3677 _ _ Non-coding RNAs involved in post-transcriptional _ regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs

NDUFC1 NADH: ubiquinone NADH dehydrogenase _ Subunit of the NADH: ubiquinone oxidoreductase, the mitochondrial electron transport, NADH oxidoreductase subunit (ubiquinone) activity first enzyme complex in the electron transport chain to ubiquinone; mitochondrial respiratory C1 located in the inner mitochondrial membrane chain complex I assembly; oxidation- reduction process

OSER1 Oxidative stress _ _ _ cellular response to hydrogen peroxide responsive serine rich 1

RPL34 Ribosomal protein L34 cadherin binding; RNA binding; EIF2 Signaling Component of the 60S subunit belongs to the L34E nuclear-transcribed mRNA catabolic structural constituent of ribosome family of ribosomal proteins. It is located in the process; nonsense-mediated decay; SRP- cytoplasm and overexpression of this gene has been dependent cotranslational protein observed in some cancer cells targeting to membrane; translation initiation

SLC46A3 Solute carrier family 46 _ _ Transmembrane protein, transports small molecules transmembrane transport member 3 across membrane. Found in lysosomal membranes where it transports catabolites from the lysosomes to the cytoplasm. Effective transporter of the cytotoxic drug maytansine

SNAPC2 Small nuclear RNA sequence-specific DNA binding _ Subunit of the snRNA-activating protein complex regulation of transcription; DNA- activating complex transcription factor activity associated with the TATA box-binding protein. Is dependent; transcription from RNA polypeptide 2 polymerase III promoter necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription

SPHK2 Sphinganine kinase ATP binding; sphinganine kinase Ceramide Signaling; One of two sphingosine kinase isozymes, catalyses the blood vessel development; cell activity; nucleotide binding; Ras PDGF Signaling sphingosine phosphorylation into sphingosine 1- proliferation; lipid phosphorylation; GTPase binding; sphingosine-1- phosphate. It mediates many cellular processes including metabolic process; negative regulation phosphate receptor activity; migration, proliferation and of apoptotic process; positive regulation transferase activity of cell proliferation; sphingosine metabolic process

TMEM17 Transmembrane protein protein binding _ Transmembrane component of the tectonic-like complex cell projection organization; cilium 17 localized at the transition zone of primary cilia and morphogenesis; smoothened signalling acting as a barrier that prevents diffusion of pathway transmembrane proteins between the cilia and plasma membrane. Required for ciliogenesis and sonic hedgehog/SHH signaling

TOMM70 Translocase of outer protein binding; protein Sirtuin Signaling Import receptor of the outer mitochondrial membrane negative regulation of cell growth mitochondrial transmembrane transporter activity Pathway that is part of the translocase of the outer membrane involved in cardiac muscle cell membrane 70 complex. Involved in the import of mitochondrial development; protein targeting to precursor proteins mitochondrion; protein transmembrane transport; response to thyroxine stimulus

TRBJ2-1 T cell receptor beta _ _ _ _ joining 2-1

TRBV7-3 T cell receptor beta _ _ _ _ variable 7-3

TRIP11 Thyroid hormone protein binding; transcription Aryl Hydrocarbon Interaction with thyroid hormone receptor beta. bone development; chondrocyte receptor interactor 11 coactivator activity receptor signalling Associated protein with Golgi apparatus. Protein N- differentiation involved in endochondral terminal region binds Golgi membranes and C-terminal bone morphogenesis; Golgi binds the minus ends of microtubules; thus, the protein is organization; intraflagellar transport thought to play a role in assembly and maintenance of involved in cilium morphogenesis; the Golgi ribbon structure around the centrosome protein glycosylation; transcription from RNA polymerase II promoter; ventricular septum development

UGT2A1 UDP glucuronosyl glucuronosyltransferase activity; Melatonin degradation Belongs to the UDP-glycosyltransferase family, cellular glucuronidation; detection of transferase family 2 transferase activity; transferring I; Nicotine degradation members of which catalyse biotransformation reactions chemical stimulus; metabolic process; member A1 complex glycosyl groups; transferring II/III; Serotonin in which lipophilic substrates are conjugated with response to stimulus; response to toxin; hexosyl groups; UDP- degradation; Thyroid glucuronic acid to increase water solubility and enhance sensory perception of smell glycosyltransferase activity hormone metabolism II; excretion. Major importance in the conjugation and Xenobiotic metabolism elimination of potentially toxic xenobiotics and signaling endogenous compounds ZDHHC2 Zinc finger DHHC-type palmitoyltransferase activity; _ Involved in cellular protein metabolic process. cellular protein metabolic process; containing 2 protein-cysteine S- Palmitoyltransferase specific for GAP43 and peptidyl-L-cysteine S-palmitoylation; palmitoleyltransferase activity; DLG4/PSD95 protein palmitoylation; protein targeting transferase activity; transferring to membrane acyl groups