LANCL2 Rabbit Polyclonal Antibody – TA344841 | Origene

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LANCL2 Rabbit Polyclonal Antibody – TA344841 | Origene

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for TA344841 LANCL2 Rabbit Polyclonal Antibody Product data: Product Type: Primary Antibodies Applications: WB Recommended Dilution: WB Reactivity: Human Host: Rabbit Isotype: IgG Clonality: Polyclonal Immunogen: The immunogen for anti-LANCL2 antibody: synthetic peptide directed towards the middle region of human LANCL2. Synthetic peptide located within the following region: EMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLMQAYK Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers. Purification: Affinity Purified Conjugation: Unconjugated Storage: Store at -20°C as received. Stability: Stable for 12 months from date of receipt. Predicted Protein Size: 51 kDa Gene Name: LanC like 2 Database Link: NP_061167 Entrez Gene 55915 Human Q9NS86 Background: LANCL2 is necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Synonyms: GPR69B; TASP Note: Immunogen Sequence Homology: Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Guinea pig: 100%; Zebrafish: 93% This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 LANCL2 Rabbit Polyclonal Antibody – TA344841 Protein Families: Druggable Genome Product images: WB Suggested Anti-LANCL2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Muscle This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.

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S12967-021-02979-Z.Pdf
Zhao et al. J Transl Med (2021) 19:372 https://doi.org/10.1186/s12967-021-02979-z Journal of Translational Medicine RESEARCH Open Access Identifcation of prognostic values defned by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients Hua‑fu Zhao1†, Xiu‑ming Zhou1,2†, Jing Wang3,4,5, Fan‑fan Chen1, Chang‑peng Wu1,6, Peng‑yu Diao1, Lin‑rong Cai1, Lei Chen1, Yan‑wen Xu1, Jing Liu7, Zong‑yang Li1, Wen‑lan Liu1, Zhong‑ping Chen3,4,5, Guo‑dong Huang1* and Wei‑ping Li1* Abstract Background: Epidermal growth factor receptor (EGFR) and lanthionine synthetase C‑like 2 (LanCL2) genes locate in the same amplicon, and co‑amplifcation of EGFR and LANCL2 is frequent in glioblastoma. However, the prognostic value of LANCL2 and EGFR co‑amplifcation, and their mRNA and protein expression in glioblastoma remain unclear yet. Methods: This study analyzed the prognostic values of the copy number variations (CNVs), mRNA and protein expression of LANCL2 and EGFR in 575 glioblastoma patients in TCGA database and 100 glioblastoma patients in tumor banks of the Shenzhen Second People’s Hospital and the Sun Yat‑sen University Cancer Center. Results: The amplifcation of LANCL2 or EGFR, and their co‑amplifcation were frequent in glioblastoma of TCGA database and our tumor banks. A signifcant correlation was found between the CNVs of LANCL2 and EGFR (p < 0.001). CNVs of LANCL2 or EGFR were signifcantly correlated with IDH1/2 mutation but not MGMT promoter methylation. Multivariate analysis showed that LANCL2 amplifcation was signifcantly correlated with reduced overall survival (OS) in younger (< 60 years) glioblastoma patients of TCGA database (p 0.043, HR 1.657) and our tumor banks (p 0.018, HR 2.199).
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