Anti-LANCL2 Monoclonal Antibody, Clone 3B22 (DCABH-2017) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-LANCL2 monoclonal antibody, clone 3B22 (DCABH-2017) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to LANCL2 Antigen Description Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Immunogen Recombinant fragment, corresponding to amino acids 212-450 of Human LANCL2 produced in E.coli (NP_061167). Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone 3B22 Purity Protein G purified Purification This antibody is purified from Mouse ascites fluid. Conjugate Unconjugated Applications WB, IHC-P, Flow Cyt Positive Control HEK293T cells transfected with LANCL2. Human ovary adenocarcinoma and thyroid carcinoma tissues. Format Liquid Size 100 μl Buffer pH: 7.30; Preservative: 0.02% Sodium azide; Constituents: 48% PBS, 50% Glycerol, 1% BSA Preservative 0.02% Sodium Azide Storage store at -20°C. Avoid repeated freeze / thaw cycles. Ship Shipped at 4°C. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) [ Homo sapiens ] Official Symbol LANCL2 Synonyms LANCL2; LanC lantibiotic synthetase component C-like 2 (bacterial); GPR69B, LanC (bacterial lantibiotic synthetase component C) like 2; lanC-like protein 2; G protein coupled receptor 69B; TASP; testis specific adriamycin sensitivity protein; G protein-c Entrez Gene ID 55915 Protein Refseq NP_061167 UniProt ID B3KTN5 Chromosome Location 7q31.1-q31.33 Function ATP binding; GTP binding; catalytic activity; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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S12967-021-02979-Z.Pdf
Zhao et al. J Transl Med (2021) 19:372 https://doi.org/10.1186/s12967-021-02979-z Journal of Translational Medicine RESEARCH Open Access Identifcation of prognostic values defned by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients Hua‑fu Zhao1†, Xiu‑ming Zhou1,2†, Jing Wang3,4,5, Fan‑fan Chen1, Chang‑peng Wu1,6, Peng‑yu Diao1, Lin‑rong Cai1, Lei Chen1, Yan‑wen Xu1, Jing Liu7, Zong‑yang Li1, Wen‑lan Liu1, Zhong‑ping Chen3,4,5, Guo‑dong Huang1* and Wei‑ping Li1* Abstract Background: Epidermal growth factor receptor (EGFR) and lanthionine synthetase C‑like 2 (LanCL2) genes locate in the same amplicon, and co‑amplifcation of EGFR and LANCL2 is frequent in glioblastoma. However, the prognostic value of LANCL2 and EGFR co‑amplifcation, and their mRNA and protein expression in glioblastoma remain unclear yet. Methods: This study analyzed the prognostic values of the copy number variations (CNVs), mRNA and protein expression of LANCL2 and EGFR in 575 glioblastoma patients in TCGA database and 100 glioblastoma patients in tumor banks of the Shenzhen Second People’s Hospital and the Sun Yat‑sen University Cancer Center. Results: The amplifcation of LANCL2 or EGFR, and their co‑amplifcation were frequent in glioblastoma of TCGA database and our tumor banks. A signifcant correlation was found between the CNVs of LANCL2 and EGFR (p < 0.001). CNVs of LANCL2 or EGFR were signifcantly correlated with IDH1/2 mutation but not MGMT promoter methylation. Multivariate analysis showed that LANCL2 amplifcation was signifcantly correlated with reduced overall survival (OS) in younger (< 60 years) glioblastoma patients of TCGA database (p 0.043, HR 1.657) and our tumor banks (p 0.018, HR 2.199).
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Revised Manuscript ID CJP-2016-11-0031R1
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