Author Manuscript Published OnlineFirst on April 20, 2017; DOI: 10.1158/1078-0432.CCR-16-2743 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Title: Long-term efficacy, survival and safety of [177Lu-DOTA0,Tyr3]octreotate in patients with gastroenteropancreatic and bronchial neuroendocrine tumors Authors: Tessa Brabander1, Wouter A van der Zwan1, Jaap JM Teunissen1, Boen LR Kam1, Richard A Feelders2, Wouter W de Herder2, Casper HJ van Eijck3, Gaston JH Franssen3, Eric P Krenning1, Dik J Kwekkeboom1† 1Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands 2Department of Internal Medicine, Erasmus Medical Center, ENETS Center of Excellence, Rotterdam, The Netherlands 3Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands Corresponding author: Tessa Brabander,
[email protected] Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. ‘s-Gravendijkwal 230 3015 CE Rotterdam Tel: +31107040321 Fax: +31107033737 Running head: Efficacy, survival and toxicity after 177Lu-DOTATATE. Keywords: Neuroendocrine tumors; Peptide receptor radionuclide therapy (PRRT), 177Lu-DOTATATE, toxicity. Conflict of Interest: DJ Kwekkeboom and EP Krenning are stockholders of Advanced Accelerators Applications, Geneva, France. 1 Downloaded from clincancerres.aacrjournals.org on September 30, 2021. © 2017 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 20, 2017; DOI: 10.1158/1078-0432.CCR-16-2743 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. TRANSLATIONAL RELEVANCE Peptide receptor radionuclide therapy (PRRT) with [177Lu-DOTA0,Tyr3]octreotate is a therapeutic option for metastasized or inoperable gastroenteropancreatic and bronchial neuroendocrine tumors that present the somatostatin receptors on their surface.