Sara M. Wasserman, Phd Curriculum Vitae CONTACT INFORMATION Neuroscience Program E-Mail
Total Page：16
File Type：pdf, Size：1020Kb
Load more
Recommended publications
-
CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical
CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical Institute Department of Neuroscience University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., NA4.118 Dallas, Texas 75390-9111 (214) 648-1876, FAX (214) 648-1801 Email: [email protected] DATE OF BIRTH: December 16, 1951 NATIONALITY: U.S. Citizen by birth EDUCATION: 1981-1983 Pharmacology Research Associate Training Program, National Institute of General Medical Sciences, Laboratory of Clinical Sciences and Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD 1979-1981 Ph.D., Institute of Neuroscience, Department of Biology, University of Oregon, Eugene, Oregon, Dr. Michael Menaker, Advisor. Summer 1977 Hopkins Marine Station, Stanford University, Pacific Grove, California 1975-1979 Department of Zoology, University of Texas, Austin, Texas 1970-1974 B.A. in Biology, Swarthmore College, Swarthmore, Pennsylvania PROFESSIONAL EXPERIENCE: 2013-present Principal Investigator, Satellite, International Institute for Integrative Sleep Medicine, World Premier International Research Center Initiative, University of Tsukuba, Japan 2009-present Professor and Chair, Department of Neuroscience, UT Southwestern Medical Center 2009-present Loyd B. Sands Distinguished Chair in Neuroscience, UT Southwestern 2009-present Investigator, Howard Hughes Medical Institute, UT Southwestern 2009-present Professor Emeritus of Neurobiology and Physiology, and Walter and Mary Elizabeth Glass Professor Emeritus in the Life Sciences, Northwestern University -
![[3 TD$DIFF]Interdisciplinary Team Science in Cell Biology](https://docslib.b-cdn.net/cover/7372/3-td-diff-interdisciplinary-team-science-in-cell-biology-237372.webp)
[3 TD$DIFF]Interdisciplinary Team Science in Cell Biology
TICB 1268 No. of Pages 3 Scientific Life Cell biology, beginning largely as micro- detailed physical–chemical mechanisms Interdisciplinary[3_TD$IF] scopic observations, followed[1_TD$IF]the molec- [7]. The data required for these models ular biology revolution, which viewed are now in sight. New gene editing meth- Team Science in genes, cells, and the machinery that ods are providing endogenous expression underlies their activities as molecular sys- of tagged and mutant cells [8], and new Cell Biology tems that could be fully characterized and live-cell imaging methods are promising Rick Horwitz1,* understood using methods of genetics biochemistry in living cells, measuring con- and biochemistry. Viewing the cell as a centrations, dynamics, equilibria, and complex, dynamic molecular composite organization [9]. Similarly, super-resolution The cell is complex. With its multi- brought insights from chemistry and phys- microscopy and cryoEM tomography, tude of components, spatial– ics to bear on biological problems. Just as which allow structure determination and [6_TD$IF] temporal character, and gene the molecular genetic era was codified by organization in situ [3,4], imaging mass expression diversity, it is challeng- the publication of Watson's book, Molec- spectrometry [10], and single-cell and ing to comprehend the cell as an ular Biology of the Gene [1], two decades spatially-resolved genomic approaches integrated system and to develop later[8_TD$IF]the Molecular Biology of the Cell by [11–13], among other image-based tech- models that predict its behaviors. I Alberts, et al. [2] served a similar purpose nologies, all point to a new golden era of suggest an approach to address for cell biology. -
Neurobiology, Endocrinology and Behavior E
Neurobiology, Endocrinology and Behavior E. Adkins-Regan, Cornell University, Ithaca, NY, USA C. S. Carter, University of Illinois at Chicago, Chicago, IL, USA ã 2010 Elsevier Ltd. All rights reserved. Introduction In subsequent centuries, many scientists examined and described the structure of the brain and nervous system Two types of mechanisms, neural and hormonal, have in an array of animal species. A common theme was to note been prominent in the history of research directed at what seemed to be marked differences in the organization uncovering the proximate physiological causes of animal of the brain, especially the forebrain, and in the relative behavior. During the first part of this history, the nervous sizes of structures and brain divisions, and to speculate and endocrine systems were envisioned as separate sys- about their relationship to behavior and intelligence. tems and were studied by somewhat different research With the publication of Charles Darwin’s theory of communities. As a result, research on physiological evolution by natural selection, these species differences mechanisms of animal behavior has tended to develop in brain structure and size began to be interpreted in an along two somewhat separate and parallel tracks. These evolutionary framework. Until the middle of the 1900s, dual origins are reflected in the organization of this sur- the dominant view had been that the brains (especially vey. Beginning in the twentieth century, several discov- forebrains) of different vertebrate classes (as represented eries led to the realization that the nervous and endocrine by a small number of species from each of the largest systems are physiologically integrated to a highly signifi- classes) were fundamentally different in organization, cant extent, which is of great importance for animal that they formed an evolutionary series progressing behavior. -
Genomic Divergence and Brain Evolution: How Regulatory DNA Influences Development of the Cerebral Cortex
Prospects & Overviews Review essays Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex Debra L. Silver1)2)3)4) The cerebral cortex controls our most distinguishing higher Introduction cognitive functions. Human-specific gene expression dif- ferences are abundant in the cerebral cortex, yet we have A large six-layered neocortex is a unique feature of only begun to understand how these variations impact brain mammalian brains. This specialized outer covering of the brain controls our higher cognitive functions including function. This review discusses the current evidence linking abstract thought and language, which together help uniquely non-coding regulatory DNA changes, including enhancers, define us as humans. Our distinguishing cognitive capacities with neocortical evolution. Functional interrogation using are specified within discrete cortical areas and are driven by animal models reveals converging roles for our genome in dynamic communication between neurons of the neocortex key aspects of cortical development including progenitor and other brain regions, as well as glial cell populations (including oligodendrocytes, microglia, and astrocytes). cell cycle and neuronal signaling. New technologies, Neurons are initially generated during human embryonic includingiPS cells and organoids, offerpotential alternatives and early fetal development, where they migrate to appropri- to modeling evolutionary modifications in a relevant species ate regions and begin establishing functional connections context. Several diseases rooted in the cerebral cortex during fetal and postnatal stages (Fig. 1). Disruptions to uniquely manifest in humans compared to other primates, cerebral cortex function arising during either development or thus highlighting the importance of understanding human adulthood, can result in neurodevelopmental and neurode- generative disorders. -
MOLECULAR CLOCKS Definition Introduction
MOLECULAR CLOCKS 583 Kishino, H., Thorne, J. L., and Bruno, W. J., 2001. Performance of Thorne, J. L., Kishino, H., and Painter, I. S., 1998. Estimating the a divergence time estimation method under a probabilistic model rate of evolution of the rate of molecular evolution. Molecular of rate evolution. Molecular Biology and Evolution, 18,352–361. Biology and Evolution, 15, 1647–1657. Kodandaramaiah, U., 2011. Tectonic calibrations in molecular dat- Warnock, R. C. M., Yang, Z., Donoghue, P. C. J., 2012. Exploring ing. Current Zoology, 57,116–124. uncertainty in the calibration of the molecular clock. Biology Marshall, C. R., 1997. Confidence intervals on stratigraphic ranges Letters, 8, 156–159. with nonrandom distributions of fossil horizons. Paleobiology, Wilkinson, R. D., Steiper, M. E., Soligo, C., Martin, R. D., Yang, Z., 23, 165–173. and Tavaré, S., 2011. Dating primate divergences through an Müller, J., and Reisz, R. R., 2005. Four well-constrained calibration integrated analysis of palaeontological and molecular data. Sys- points from the vertebrate fossil record for molecular clock esti- tematic Biology, 60,16–31. mates. Bioessays, 27, 1069–1075. Yang, Z., and Rannala, B., 2006. Bayesian estimation of species Parham, J. F., Donoghue, P. C. J., Bell, C. J., et al., 2012. Best practices divergence times under a molecular clock using multiple fossil for justifying fossil calibrations. Systematic Biology, 61,346–359. calibrations with soft bounds. Molecular Biology and Evolution, Peters, S. E., 2005. Geologic constraints on the macroevolutionary 23, 212–226. history of marine animals. Proceedings of the National Academy Zuckerkandl, E., and Pauling, L., 1962. Molecular disease, evolution of Sciences, 102, 12326–12331. -
Neuromechanics of Coordination During Swallowing in Aplysia Californica
1470 • The Journal of Neuroscience, February 1, 2006 • 26(5):1470–1485 Behavioral/Systems/Cognitive Neuromechanics of Coordination during Swallowing in Aplysia californica Hui Ye,1 Douglas W. Morton,2 and Hillel J. Chiel1,2,3 Departments of 1Biomedical Engineering, 2Neuroscience, and 3Biology, Case Western Reserve University, Cleveland, Ohio 44106-7080 Bernstein (1967) hypothesized that preparation of the periphery was crucial for correct responses to motor output. To test this hypothesis in a behaving animal, we examined the roles of two identified motor neurons, B7 and B8, which contribute to feeding behavior in the marine mollusk Aplysia californica. Neuron B7 innervates a hinge muscle and has no overt behavioral effect during smaller-amplitude (type A) swallows, because the hinge muscle is too short to exert force. Neuron B8 activates a muscle (I4) that acts solely to grasp material during type A swallows. During larger-amplitude (type B) swallows, the behavioral actions of both motor neurons change, because the larger-amplitude anterior movement of the grasper sets up the periphery to respond differently to motor outputs. The larger anterior movement stretches the hinge muscle, so that activating neuron B7 mediates the initial retraction phase of swallowing. The changed position of the I4 muscle allows neuron B8 not only to induce grasping but also to pull material into the buccal cavity, contributing to retraction. Thus, larger-amplitude swallows are associated with the expression of two new degrees of freedom (use of the hinge to retract and use of the grasper to retract) that are essential for mediating type B swallows. These results provide a direct demonstration of Bernstein’s hypothesis that properly positioning the periphery can be crucial for its ability to correctly respond to motor output and also demonstrate that biomechanical context can alter the functions of identified motor neurons. -
Biology & Biochemistry
Top Peer Reviewed Journals – Biology & Biochemistry Presented to Iowa State University Presented by Thomson Reuters Biology & Biochemistry The subject discipline for Biology & Biochemistry is made of 14 narrow subject categories from the Web of Science. The 14 categories that make up Biology & Biochemistry are: 1. Anatomy & Morphology 8. Cytology & Histology 2. Biochemical Research Methods 9. Endocrinology & Metabolism 3. Biochemistry & Molecular Biology 10. Evolutionary Biology 4. Biology 11. Medicine, Miscellaneous 5. Biology, Miscellaneous 12. Microscopy 6. Biophysics 13. Parasitology 7. Biotechnology & Applied Microbiology 14. Physiology The chart below provides an ordered view of the top peer reviewed journals within the 1st quartile for Biology & Biochemistry based on Impact Factors (IF), three year averages and their quartile ranking. Journal 2009 IF 2010 IF 2011 IF Average IF ANNUAL REVIEW OF BIOCHEMISTRY 29.87 29.74 34.31 31.31 PHYSIOLOGICAL REVIEWS 37.72 28.41 26.86 31.00 NATURE BIOTECHNOLOGY 29.49 31.09 23.26 27.95 CANCER CELL 25.28 26.92 26.56 26.25 ENDOCRINE REVIEWS 19.76 22.46 19.92 20.71 NATURE METHODS 16.87 20.72 19.27 18.95 ANNUAL REVIEW OF BIOPHYSICS AND 18.95 18.95 BIOMOLECULAR STRUCTURE ANNUAL REVIEW OF PHYSIOLOGY 18.17 16.1 20.82 18.36 Annual Review of Biophysics 19.3 17.52 13.57 16.80 Nature Chemical Biology 16.05 15.8 14.69 15.51 NATURE STRUCTURAL & MOLECULAR 12.27 13.68 12.71 12.89 BIOLOGY PLOS BIOLOGY 12.91 12.47 11.45 12.28 TRENDS IN BIOCHEMICAL SCIENCES 11.57 10.36 10.84 10.92 QUARTERLY REVIEWS OF BIOPHYSICS -
Conceptual Breakthroughs in Developmental Biology
Swarthmore College Works Biology Faculty Works Biology 9-1-1998 Conceptual Breakthroughs In Developmental Biology Scott F. Gilbert Swarthmore College, [email protected] Follow this and additional works at: https://works.swarthmore.edu/fac-biology Part of the Biology Commons Let us know how access to these works benefits ouy Recommended Citation Scott F. Gilbert. (1998). "Conceptual Breakthroughs In Developmental Biology". Journal Of Biosciences. Volume 23, Issue 3. 169-176. DOI: 10.1007/BF02720017 https://works.swarthmore.edu/fac-biology/189 This work is brought to you for free by Swarthmore College Libraries' Works. It has been accepted for inclusion in Biology Faculty Works by an authorized administrator of Works. For more information, please contact [email protected]. SCOTT F GILBERT Department of Biology, Martin Laboratories of Biology, Swarthmore College, Swarthmore, PA 19081, USA (Fax, +610-328-8663; Email, [email protected]) I 1. Developmental biologists can indeed explain Introduction development Revising a textbook is a fascinating exercise that allows Fifteen years ago, embryology was what could be char- one to see quite starkly the changes that have occurred acterized as the only field of science that celebrated its in one's discipline through the subsequent editions. As questions more than its answers. We had the greatest I revise a textbook that was originally published in 1985, problems one could imagine: How does the brain develop? I can see the numerous advances that have transformed How do the eyes form? How does our back develop the discipline of developmental biology. But even more differently than our front? How are the arteries and veins important and much rarer than the advances are the true connected to the heart? But we had very few answers. -
Microbiota Interactions: a Need for New Types of Studies
CAUSE TO REFLECT Thoughts & Opinion www.bioessays-journal.com Advancing Our Functional Understanding of Host–Microbiota Interactions: A Need for New Types of Studies Jinru He, Janina Lange, Georgios Marinos, Jay Bathia, Danielle Harris, Ryszard Soluch, Vaibhvi Vaibhvi, Peter Deines, M. Amine Hassani, Kim-Sara Wagner, Roman Zapien-Campos, Cornelia Jaspers, and Felix Sommer* 1. Introduction all associated archaea, bacteria, fungi, and viruses. These associ- ations greatly affect the health and life history of the host, which Multicellular life evolved in the presence of microorganisms and led to a new understanding of “self” and establishment of the formed complex associations with their microbiota, the sum of “metaorganism” concept.[1] The Collaborative Research Centre (CRC) 1182 aims at elucidating the evolution and function of metaorganisms. Its annual conference, the Young Investigator J. He, J. Lange, J. Bathia, D. Harris, V. Vaibhvi, Dr. P. Deines Zoological Institute Research Day (YIRD), serves as a platform for scientists of vari- University of Kiel ous disciplines to share novel findings on host–microbiota inter- Kiel 24118, Germany actions, thereby providing a comprehensive overview of recent G. Marinos developments and new directions in metaorganism research. Institute of Experimental Medicine Even though we have gained tremendous insights into the com- University of Kiel position and dynamics of host-associated microbial communi- Kiel 24105, Germany ties and their correlations with host health and disease, it also R. Soluch Institute for General Microbiology became evident that moving from correlative toward functional University of Kiel studies is needed to examine the underlying mechanisms of in- Kiel 24118, Germany teractions within the metaorganism. -
The Scope of Neuroethology
THE BEHAVIORAL AND BRAIN SCIENCES (1984) 7, 367-412 Printed in the United States of America The scope of neuroethology Graham Hoyle Institute of Neuroscience, University of Oregon, Eugene, Oreg. 97403 Abstract: Neuroethology, an interdisciplinary subdivision of neuroscience, has emerged in recent years. Since 1976 there has been a regular session under this heading at the annual meeting of the Society for Neuroscience. In 1980 two introductory texts in English were published on the subject (Ewert 1980; Guthrie 1980), and a third (Camhi 1984) was published recently. There is widespread interest in neural mechanisms underlying behavior, but they encompass such a vast array of often unrelated topics that proponents do not share common goals. This article describes the emergence of ethology as a discipline, pointing out that its practitioners were successful because they confined their research to stereotyped, complex, nonlearned, innate behavioral acts. A limited number of profoundly significant principles emerged. Each of these is redefined. The major concepts of earlier ethology were embodied in a simple hydraulic model used by Konrad Lorenz in 1949 (Lorenz 1950). It is pointed out that this model implies the existence of common neurophysiological mechanisms and neuronal circuitry. This model has now been made obsolete by neurophysiological progress, but with appropriate ~nodificationsan updated version may still be useful in focusing attention on possible principles. The initial aim of neuroethology should be to examine the neurophysiological events in a variety of behaviors, exhibited by diverse animals from different phyla, which meet the criteria of innate behavioral acts. The behaviors should be sufficiently complex to interest ethologists, yet they should be addressable with neurophysiological methods down to the cellular level. -
Macroevolution of Complex Cytoskeletal Systems in Euglenids Brian S
Review articles Macroevolution of complex cytoskeletal systems in euglenids Brian S. Leander,* Heather J. Esson, and Susana A. Breglia Summary and are capable of photosynthesis. The origin of plastids in Euglenids comprise a group of single-celled eukaryotes eukaryotes involved phagotrophic cells that engulfed and with diverse modes of nutrition, including phagotrophy and photosynthesis. The level of morphological diversity retained cyanobacterial prey, a process called ‘‘primary’’ present in this group provides an excellent system for endosymbiosis. The subsequent evolutionary history of demonstrating evolutionary transformations in morpho- photosynthesis in eukaryotes is exceedingly convoluted and logical characters. This diversity also provides compel- involved at least three independent endosymbiotic events ling evidence for major events in eukaryote evolution, between phagotrophic eukaryotes and eukaryotic prey cells such as the punctuated effects of secondary endo- that already contained primary plastids (e.g. green algae and symbiosis and mutations in underlying developmental (2,3) mechanisms. In this essay, we synthesize evidence for red algae). Once photosynthesis was established in a the origin, adaptive significance and diversification of the previously phagotrophic cell, the evolutionary pressures on euglenid cytoskeleton, especially pellicle ultrastructure, the cytoskeletal systems involved in locomotion and feeding pellicle surface patterns, pellicle strip number and the changed. This gave rise to fundamental modifications -
Neuroethology in Neuroscience Why Study an Exotic Animal
Neuroethology in Neuroscience or Why study an exotic animal Nobel prize in Physiology and Medicine 1973 Karl von Frisch Konrad Lorenz Nikolaas Tinbergen for their discoveries concerning "organization and elicitation of individual and social behaviour patterns". Behaviour patterns become explicable when interpreted as the result of natural selection, analogous with anatomical and physiological characteristics. This year's prize winners hold a unique position in this field. They are the most eminent founders of a new science, called "the comparative study of behaviour" or "ethology" (from ethos = habit, manner). Their first discoveries were made on insects, fishes and birds, but the basal principles have proved to be applicable also on mammals, including man. Nobel prize in Physiology and Medicine 1973 Karl von Frisch Konrad Lorenz Nikolaas Tinbergen Ammophila the sand wasp Black headed gull Niko Tinbergen’s four questions? 1. How the behavior of the animal affects its survival and reproduction (function)? 2. By how the behavior is similar or different from behaviors in other species (phylogeny)? 3. How the behavior is shaped by the animal’s own experiences (ontogeny)? 4. How the behavior is manifested at the physiological level (mechanism)? Neuroethology as a sub-field in brain research • A large variety of research models and a tendency to focus on esoteric animals and systems (specialized behaviors). • Studying animals while ignoring the relevancy to humans. • Studying the brain in the context of the animal’s natural behavior. • Top-down approach. Archer fish Prof. Ronen Segev Ben-Gurion University Neuroethology as a sub-field in brain research • A large variety of research models and a tendency to focus on esoteric animals and systems (specialized behaviors).