G3: Genes|Genomes|Genetics Early Online, published on July 13, 2016 as doi:10.1534/g3.116.032961 G3 Genes | Genomes | Genetics R1_23_06_16 (~ 5500 words) Analyses of Compact Trichinella Kinomes Reveal a MOS-like Protein Kinase with a Unique N-terminal Domain Andreas J. Stroehlein*, Neil D. Young*, Pasi K. Korhonen*, Bill C.H. Chang*,†, Paul W. Sternberg‡, Giuseppe La Rosa§, Edoardo Pozio§ and Robin B. Gasser*,1 *Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia †Yourgene Bioscience, Shu-Lin District, New Taipei City 23863, Taiwan ‡HHMI and Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA §Istituto Superiore di Sanità, 00161 Rome, Italy 1Corresponding author: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Corner of Flemington Road & Park Drive, Parkville, Victoria 3010, Australia. E- mail:
[email protected] Abbreviations AGC, protein kinases A, G and C, and other nucleoside-regulated kinases; aPK, atypical protein kinase; CAMK, Ca2+/calmodulin-dependent kinase; CK1, casein kinase 1; CMGC, cyclin-dependent kinases (CDKs), mitogen-activated protein kinases (MAPKs), glycogen synthase kinases (GSKs) and CDK-like kinases; ePK, eukaryotic protein kinase; KEGG, Kyoto Encyclopedia of Genes and Genomes; MLKL, mixed-lineage kinase domain-like protein; MOS, v-mos Moloney murine sarcoma viral oncogene homolog; RGC, receptor guanylate cyclase; STE, MAPK cascade kinases; TK, tyrosine kinase; TKL, tyrosine kinase-like kinase; TTBK, tau-tubulin kinase. 1 © The Author(s) 2013. Published by the Genetics Society of America. G3 Genes | Genomes | Genetics R1_23_06_16 (~ 5500 words) ABSTRACT Parasitic worms of the genus Trichinella (phylum Nematoda; class Enoplea) represent a complex of at least twelve taxa that infect a range of different host animals, including humans, around the world.